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15 results on '"Kaewpan, Anek"'

1. Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged

Author

PERCH Study Group, Higdon, Melissa M., Le, Tham, O'Brien, Katherine L., Murdoch, David R., Prosperi, Christine, Baggett, Henry C., Brooks, W. Abdullah, Feikin, Daniel R., Hammitt, Laura L., Howie, Stephen R. C., Kotloff, Karen L., Levine, Orin S., Scott, J. Anthony G., Thea, Donald M., Awori, Juliet O., Baillie, Vicky L., Cascio, Stephanie, Chuananon, Somchai, DeLuca, Andrea N., Driscoll, Amanda J., Ebruke, Bernard E., Endtz, Hubert P., Kaewpan, Anek, Kahn, Geoff, Karani, Angela, Karron, Ruth A., Moore, David P., Park, Daniel E., Rahman, Mohammed Ziaur, Salaudeen, Rasheed, Seidenberg, Phil, Somwe, Somwe Wa, Sylla, Mamadou, Tapia, Milagritos D., Zeger, Scott L., Knoll, Maria Deloria, and Madhi, Shabir A.

Published
2017

2. The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia

Author

PERCH Study Group, Driscoll, Amanda J., Knoll, Maria Deloria, Hammitt, Laura L., Baggett, Henry C., Brooks, W. Abdullah, Feikin, Daniel R., Kotloff, Karen L., Levine, Orin S., Madhi, Shabir A., O'Brien, Katherine L., Scott, J. Anthony G., Thea, Donald M., Howie, Stephen R. C., Adrian, Peter V., Ahmed, Dilruba, DeLuca, Andrea N., Ebruke, Bernard E., Gitahi, Caroline, Higdon, Melissa M., Kaewpan, Anek, Karani, Angela, Karron, Ruth A., Mazumder, Razib, McLellan, Jessica, Moore, David P., Mwananyanda, Lawrence, Park, Daniel E., Prosperi, Christine, Rhodes, Julia, Saifullah, Md., Seidenberg, Phil, Sow, Samba O., Tamboura, Boubou, Zeger, Scott L., and Murdoch, David R.

Published
2017

4. Burkholderia pseudomallei pathogenesis in human skin fibroblasts: A Bsa type III secretion system is involved in the invasion, multinucleated giant cell formation, and cellular damage

Author

Kaewpan, Anek, primary, Duangurai, Taksaon, additional, Rungruengkitkun, Amporn, additional, Muangkaew, Watcharamat, additional, Kanjanapruthipong, Tapanee, additional, Jitprasutwit, Niramol, additional, Ampawong, Sumate, additional, Sukphopetch, Passanesh, additional, Chantratita, Narisara, additional, and Pumirat, Pornpan, additional

Published
2022
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5. Incidence of Pneumococcal Bacteremia Requiring Hospitalization in Rural Thailand

Author

Baggett, Henry C., Peruski, Leonard F., Olsen, Sonja J., Thamthitiwat, Somsak, Rhodes, Julia, Dejsirilert, Surang, Wongjindanon, Wanna, Dowell, Scott F., Fischer, Julie E., Areerat, Peera, Sornkij, Denchai, Jorakate, Possawat, Kaewpan, Anek, Prapasiri, Prabda, Naorat, Sathapana, Sangsuk, Leelawadee, Eampokalap, Boonchuay, Moore, Matthew R., Carvalho, Gloria, Beall, Bernard, Ungchusak, Kumnuan, and Maloney, Susan A.

Published
2009
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6. Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus-Associated Pneumonia Among Children Aged <5 Years in the PERCH Study

Author

Higdon, Melissa M, Le, Tham, O'Brien, Katherine L, Murdoch, David R, Prosperi, Christine, Baggett, Henry C, Brooks, W Abdullah, Feikin, Daniel R, Hammitt, Laura L, Howie, Stephen RC, Kotloff, Karen L, Levine, Orin S, Scott, J Anthony G, Thea, Donald M, Awori, Juliet O, Baillie, Vicky L, Cascio, Stephanie, Chuananon, Somchai, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Endtz, Hubert P, Kaewpan, Anek, Kahn, Geoff, Karani, Angela, Karron, Ruth A, Moore, David P, Park, Daniel E, Rahman, Mohammed Ziaur, Salaudeen, Rasheed, Seidenberg, Phil, Somwe, Somwe Wa, Sylla, Mamadou, Tapia, Milagritos D, Zeger, Scott L, Deloria Knoll, Maria, Madhi, Shabir A, and PERCH Study Group

Subjects
respiratory tract diseases
Abstract

BACKGROUND.: Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia. We evaluated the sensitivity and specificity of CRP for identifying bacterial vs respiratory syncytial virus (RSV) pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) multicenter case-control study. METHODS.: We measured serum CRP levels in cases with World Health Organization-defined severe or very severe pneumonia and a subset of community controls. We evaluated the sensitivity and specificity of elevated CRP for "confirmed" bacterial pneumonia (positive blood culture or positive lung aspirate or pleural fluid culture or polymerase chain reaction [PCR]) compared to "RSV pneumonia" (nasopharyngeal/oropharyngeal or induced sputum PCR-positive without confirmed/suspected bacterial pneumonia). Receiver operating characteristic (ROC) curves were constructed to assess the performance of elevated CRP in distinguishing these cases. RESULTS.: Among 601 human immunodeficiency virus (HIV)-negative tested controls, 3% had CRP ≥40 mg/L. Among 119 HIV-negative cases with confirmed bacterial pneumonia, 77% had CRP ≥40 mg/L compared with 17% of 556 RSV pneumonia cases. The ROC analysis produced an area under the curve of 0.87, indicating very good discrimination; a cut-point of 37.1 mg/L best discriminated confirmed bacterial pneumonia (sensitivity 77%) from RSV pneumonia (specificity 82%). CRP ≥100 mg/L substantially improved specificity over CRP ≥40 mg/L, though at a loss to sensitivity. CONCLUSIONS.: Elevated CRP was positively associated with confirmed bacterial pneumonia and negatively associated with RSV pneumonia in PERCH. CRP may be useful for distinguishing bacterial from RSV-associated pneumonia, although its role in discriminating against other respiratory viral-associated pneumonia needs further study.

Published
2017

7. The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia

Author

Driscoll, Amanda J., primary, Deloria Knoll, Maria, additional, Hammitt, Laura L., additional, Baggett, Henry C., additional, Brooks, W. Abdullah, additional, Feikin, Daniel R., additional, Kotloff, Karen L., additional, Levine, Orin S., additional, Madhi, Shabir A., additional, O’Brien, Katherine L., additional, Scott, J. Anthony G., additional, Thea, Donald M., additional, Howie, Stephen R. C., additional, Adrian, Peter V., additional, Ahmed, Dilruba, additional, DeLuca, Andrea N., additional, Ebruke, Bernard E., additional, Gitahi, Caroline, additional, Higdon, Melissa M., additional, Kaewpan, Anek, additional, Karani, Angela, additional, Karron, Ruth A., additional, Mazumder, Razib, additional, McLellan, Jessica, additional, Moore, David P., additional, Mwananyanda, Lawrence, additional, Park, Daniel E., additional, Prosperi, Christine, additional, Rhodes, Julia, additional, Saifullah, Md., additional, Seidenberg, Phil, additional, Sow, Samba O., additional, Tamboura, Boubou, additional, Zeger, Scott L., additional, and Murdoch, David R., additional

Published
2017
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10. Incidence and Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children Younger Than 5 Years in Rural Thailand

Author

Hasan, Reem, primary, Rhodes, Julia, additional, Thamthitiwat, Somsak, additional, Olsen, Sonja J., additional, Prapasiri, Prabda, additional, Naorat, Sathapana, additional, Chittaganpitch, Malinee, additional, Henchaichon, Sununta, additional, Dejsirilert, Surang, additional, Srisaengchai, Prasong, additional, Sawatwong, Pongpun, additional, Jorakate, Possawat, additional, Kaewpan, Anek, additional, Fry, Alicia M., additional, Erdman, Dean, additional, Chuananon, Somchai, additional, Amornintapichet, Tussanee, additional, Maloney, Susan A., additional, and Baggett, Henry C., additional

Published
2014
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11. Pneumococcal Bacteremia Requiring Hospitalization in Rural Thailand: An Update on Incidence, Clinical Characteristics, Serotype Distribution, and Antimicrobial Susceptibility, 2005–2010

Author

Rhodes, Julia, primary, Dejsirilert, Surang, additional, Maloney, Susan A., additional, Jorakate, Possawat, additional, Kaewpan, Anek, additional, Salika, Prasert, additional, Akarachotpong, Thantapat, additional, Prapasiri, Prabda, additional, Naorat, Sathapana, additional, Areerat, Peera, additional, Ruayajin, Asadang, additional, Sawanpanyalert, Pathom, additional, Akarasewi, Pasakorn, additional, Peruski, Leonard F., additional, and Baggett, Henry C., additional

Published
2013
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12. Incidence of Bacteremic Melioidosis in Eastern and Northeastern Thailand

Author

Bhengsri, Saithip, primary, Peruski, Leonard F., additional, Baggett, Henry C., additional, Tanwisaid, Kittisak, additional, Jorakate, Possawat, additional, Kaewpan, Anek, additional, Salika, Prasert, additional, Naorat, Sathapana, additional, Dejsirilert, Surang, additional, Chantra, Somrak, additional, Prapasiri, Prabda, additional, Maloney, Susan A., additional, and Thamthitiwat, Somsak, additional

Published
2011
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13. Antibiotic Use in Thailand: Quantifying Impact on Blood Culture Yield and Estimates of Pneumococcal Bacteremia Incidence

Author

Rhodes, Julia, primary, Peruski, Leonard F., additional, Tanwisaid, Kittisak, additional, Olsen, Sonja J., additional, Jorakate, Possawat, additional, Thamthitiwat, Somsak, additional, Hyder, Joseph A., additional, Baggett, Henry C., additional, Chantra, Somrak, additional, Dejsirilert, Surang, additional, Fisher, Cindy, additional, Maloney, Susan A., additional, Dowell, Scott F., additional, and Kaewpan, Anek, additional

Published
2010
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14. Contribution of the BacT/Alert MB MycobacteriumBottle to Bloodstream Infection Surveillance in Thailand: Added Yield for Burkholderia pseudomallei

Author

Jorakate, Possawat, Higdon, Melissa, Kaewpan, Anek, Makprasert, Sirirat, Yuenprakhon, Somkhit, Tawisaid, Kittisak, Dejsirilert, Surang, Whistler, Toni, and Baggett, Henry C.

Abstract

ABSTRACTCommunity-acquired bloodstream infections cause substantial morbidity and mortality worldwide, but microbiology capacity and surveillance limitations have challenged good descriptions of pathogen distribution in many regions, including Southeast Asia. Active surveillance for bloodstream infections has been conducted in two rural Thailand provinces for >7 years. Blood specimens were divided into two culture bottles, one optimized for aerobic growth (F bottle) and a second for enhanced growth of mycobacteria (MB bottle), and processed with the BactT/Alert 3D system. Because the routine use of MB culture bottles is resource intensive (expensive and requires prolonged incubation), we assessed the added yield of MB bottles by comparing the proportion of pathogens detected by MB versus that by F bottles from 2005 to 2012. Of 63,066 blood cultures, 7,296 (12%) were positive for at least one pathogen; the most common pathogens were Escherichia coli(28%), Burkholderia pseudomallei(11%), Klebsiella pneumoniae(9%), and Staphylococcus aureus(6%). Two bottles improved the yield overall, but the added yield attributable to the MB bottles was limited to a few pathogens. In addition to the detection of mycobacteria and some fungi, MB bottles improved the detection of B. pseudomallei(27% [MB] versus 8% [F]; P< 0.0001), with added benefit if therapy was initiated prior to the blood culture. The targeted use of MB bottles is warranted for patients at risk for mycobacterial and fungal infections and for infection with B. pseudomallei, a common cause of septicemia in Thailand.

Published
2014
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15. Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus-Associated Pneumonia Among Children Aged <5 Years in the PERCH Study.

Author

Higdon MM, Le T, O'Brien KL, Murdoch DR, Prosperi C, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Levine OS, Scott JAG, Thea DM, Awori JO, Baillie VL, Cascio S, Chuananon S, DeLuca AN, Driscoll AJ, Ebruke BE, Endtz HP, Kaewpan A, Kahn G, Karani A, Karron RA, Moore DP, Park DE, Rahman MZ, Salaudeen R, Seidenberg P, Somwe SW, Sylla M, Tapia MD, Zeger SL, Deloria Knoll M, and Madhi SA

Subjects
Bacteria genetics, Bacteria isolation & purification, Biomarkers blood, Case-Control Studies, Child, Preschool, Community-Acquired Infections diagnosis, Female, Humans, Infant, Infant, Newborn, Male, Nasopharynx virology, Oropharynx virology, Pneumonia, Bacterial microbiology, Pneumonia, Viral virology, Polymerase Chain Reaction, ROC Curve, Respiratory Syncytial Virus Infections blood, Respiratory Syncytial Virus, Human genetics, Respiratory Syncytial Virus, Human isolation & purification, Sensitivity and Specificity, C-Reactive Protein analysis, Pneumonia, Bacterial diagnosis, Pneumonia, Viral diagnosis
Abstract

Background.: Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia. We evaluated the sensitivity and specificity of CRP for identifying bacterial vs respiratory syncytial virus (RSV) pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) multicenter case-control study., Methods.: We measured serum CRP levels in cases with World Health Organization-defined severe or very severe pneumonia and a subset of community controls. We evaluated the sensitivity and specificity of elevated CRP for "confirmed" bacterial pneumonia (positive blood culture or positive lung aspirate or pleural fluid culture or polymerase chain reaction [PCR]) compared to "RSV pneumonia" (nasopharyngeal/oropharyngeal or induced sputum PCR-positive without confirmed/suspected bacterial pneumonia). Receiver operating characteristic (ROC) curves were constructed to assess the performance of elevated CRP in distinguishing these cases., Results.: Among 601 human immunodeficiency virus (HIV)-negative tested controls, 3% had CRP ≥40 mg/L. Among 119 HIV-negative cases with confirmed bacterial pneumonia, 77% had CRP ≥40 mg/L compared with 17% of 556 RSV pneumonia cases. The ROC analysis produced an area under the curve of 0.87, indicating very good discrimination; a cut-point of 37.1 mg/L best discriminated confirmed bacterial pneumonia (sensitivity 77%) from RSV pneumonia (specificity 82%). CRP ≥100 mg/L substantially improved specificity over CRP ≥40 mg/L, though at a loss to sensitivity., Conclusions.: Elevated CRP was positively associated with confirmed bacterial pneumonia and negatively associated with RSV pneumonia in PERCH. CRP may be useful for distinguishing bacterial from RSV-associated pneumonia, although its role in discriminating against other respiratory viral-associated pneumonia needs further study., (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.)

Published
2017
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