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Your search keyword '"Kadosawa, Tsuyoshi"' showing total 253 results
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253 results on '"Kadosawa, Tsuyoshi"'

17. Long-term Treatment with Toceranib Phosphate in a Dog with Metastatic Primary Pulmonary Adenocarcinoma

Author

Tamura Yu, Endo Yoshifumi, Kadosawa Tsuyoshi, Niwa Akihiro, and Matsuda Kazuya

Subjects
0301 basic medicine, medicine.medical_specialty, Long term treatment, Toceranib Phosphate, 040301 veterinary sciences, business.industry, Pulmonary adenocarcinoma, 04 agricultural and veterinary sciences, Gastroenterology, 0403 veterinary science, 03 medical and health sciences, 030104 developmental biology, Internal medicine, Medicine, business, Biomedical engineering
Published
2017

22. Occurrence and molecular characteristics of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius in an academic veterinary hospital

Author

Ishihara, Kanako, Shimokubo, Natsumi, Sakagami, Akie, Ueno, Hiroshi, Kadosawa, Tsuyoshi, Muramatsu, Yasukazu, Yanagisawa, Chie, Hanaki, Hideaki, Nakajima, Chie, Suzuki, Yasuhiko, and Tamura, Yutaka

Subjects
Logistic regression -- Usage, Staphylococcus aureus -- Genetic aspects, Staphylococcus aureus -- Health aspects, Veterinary hospitals -- Environmental aspects, Biological sciences
Abstract

The occurrence and characteristics of methicillin-resistant Staphylococcus pseudintermedius (MRCPS) isolates in a veterinary hospital is examined in order to establish the transmission route of MRCPS in veterinary hospitals and also with the aim of preventing the spread of MRCPS infection. MRCPS is isolated from environmental samples collected in a veterinary hospital for evaluating the methicillin-resistant Staphylococcus aureus (MRSA) transmission cycle through environmental surfaces in the veterinary hospital.

Published
2010

26. Histological and immunohistochemical evaluation of stroma variations and their correlation with the Ki-67 index and expressions of glucose transporter 1 and monocarboxylate transporter 1 in canine thyroid C-cell carcinomas

Author

KAWAMURA, Yoshio, primary, MIZOOKU, Hiroko, additional, OKAMOTO, Minoru, additional, MATSUDA, Kazuya, additional, OMACHI, Tetsuo, additional, HIRAYAMA, Kazuko, additional, KADOSAWA, Tsuyoshi, additional, and TANIYAMA, Hiroyuki, additional

Published
2016
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37. Evaluation of hydroxyapatite ceramic vertebral spacers with different porosities and their binding capability to the vertebral body : an experimental study in sheep

Author

Ito, Manabu, Kotani, Yoshihisa, Hojo, Yoshihiro, Abumi, Kuniyoshi, Kadosawa, Tsuyoshi, Minami, Akio, Ito, Manabu, Kotani, Yoshihisa, Hojo, Yoshihiro, Abumi, Kuniyoshi, Kadosawa, Tsuyoshi, and Minami, Akio

Abstract

OBJECT. The aim of this study was to evaluate the degree of bone ingrowth and bonding stiffness at the surface of hydroxyapatite ceramic (HAC) spacers with different porosities in an animal model and to discuss the ideal porous characteristics of these spacers for anterior spinal reconstruction. METHODS. Twenty-one adult sheep (age 1–2 years, mean weight 70 kg) were used in this experiment. Surgery consisted of anterior lumbar interbody fusion at L2–3 and L4–5, insertion of an HAC spacer (10 * 13 * 24 mm) with three different porosities (0, 3, and 15%), and single-rod anterior instrumentation. At 4 and 6 months postoperatively, the lumbar spines were harvested. Bonding conditions at the bone–HAC spacer interface were evaluated using neuroimages and biomechanically. A histological evaluation was also conducted to examine the state of bone ingrowth at the surface of the HAC spacer. Biomechanical testing showed that the bonding strength of HAC at 6 months postoperatively was 0.047 MPa in 0% porosity spacers, 0.39 MPa in 3%, and 0.49 MPa in 15% porosity spacers. The histological study showed that there was a soft-tissue layer at the surface of the HAC spacer with 0% porosity. Direct bonding was observed between bone and spacers with 3 or 15% porosity. Micro–computed tomography scans showed direct bonding between the bone and HAC with 3 or 15% porosity. No direct bonding was observed in HAC with 0% porosity. CONCLUSIONS. Dense (0%) HAC anterior vertebral spacers did not achieve direct bonding to the bone in the sheep model. The HAC vertebral spacers with 3 or 15% porosity showed proof of direct bonding to the bone at 6 months postoperatively. The higher porosity HAC spacer showed better bonding stiffness to the bone.

Published
2007

41. Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra-high strength bioresorbable spinal stabilization.

Author

1000040312368, Kotani, Yoshihisa, Abumi, Kuniyoshi, Shikinami, Yasuo, Takahata, Masahiko, Kadoya, Ken, Kadosawa, Tsuyoshi, 1000020133738, Minami, Akio, Kaneda, Kiyoshi, 1000040312368, Kotani, Yoshihisa, Abumi, Kuniyoshi, Shikinami, Yasuo, Takahata, Masahiko, Kadoya, Ken, Kadosawa, Tsuyoshi, 1000020133738, Minami, Akio, and Kaneda, Kiyoshi

Abstract

OBJECT: This 2-year experimental study was conducted to investigate the efficacy of a bioactive three-dimensional (3D) fabric disc for lumbar intervertebral disc replacement. The authors used a bioresorbable spinal fixation rod consisting of a forged composite of particulate unsintered hydroxyapatite/poly-L-lactide acid (HA/PLLA) for stability augmentation. The biomechanical and histological alterations as well as possible device-related loosening were examined at 2 years postoperatively. METHODS: Two lumbar intervertebral discs (L2-3 and L4-5) were replaced with the 3D fabric discs, which were augmented by two titanium screws and a spanning bioresorbable rod (HA/PLLA). The segmental biomechanics and interface bone ingrowth were investigated at 6, 15, and 24 months postoperatively, and results were compared with the other two surgical groups (3D fabric disc alone; 3D fabric disc with additional anterior instrumentation stabilization). The 3D fabric disc and HA/PLLA-spinal segments demonstrated segmental mobility at 15 and 24 months; however, the range of motion (ROM) in flexion-extension decreased to 49 and 40%, respectively, despite statistically equivalent preserved torsional ROM. Histologically there was excellent osseous fusion at the 3D fabric disc surface-vertebral body interface. At 2 years posttreatment, no adverse tissue reaction nor aseptic loosening of the device was observed. CONCLUSIONS: Intervertebral disc replacement with the 3D fabric disc was viable and when used in conjunction with the bioresorbable HA/PLLA spinal augmentation. Further refinements of device design to create a stand-alone type are necessary to obviate the need for additional spinal stabilization.

Published
2004

42. Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra-high strength bioresorbable spinal stabilization.

Author

Kotani, Yoshihisa, Abumi, Kuniyoshi, Shikinami, Yasuo, Takahata, Masahiko, Kadoya, Ken, Kadosawa, Tsuyoshi, Minami, Akio, Kaneda, Kiyoshi, Kotani, Yoshihisa, Abumi, Kuniyoshi, Shikinami, Yasuo, Takahata, Masahiko, Kadoya, Ken, Kadosawa, Tsuyoshi, Minami, Akio, and Kaneda, Kiyoshi

Abstract

OBJECT: This 2-year experimental study was conducted to investigate the efficacy of a bioactive three-dimensional (3D) fabric disc for lumbar intervertebral disc replacement. The authors used a bioresorbable spinal fixation rod consisting of a forged composite of particulate unsintered hydroxyapatite/poly-L-lactide acid (HA/PLLA) for stability augmentation. The biomechanical and histological alterations as well as possible device-related loosening were examined at 2 years postoperatively. METHODS: Two lumbar intervertebral discs (L2-3 and L4-5) were replaced with the 3D fabric discs, which were augmented by two titanium screws and a spanning bioresorbable rod (HA/PLLA). The segmental biomechanics and interface bone ingrowth were investigated at 6, 15, and 24 months postoperatively, and results were compared with the other two surgical groups (3D fabric disc alone; 3D fabric disc with additional anterior instrumentation stabilization). The 3D fabric disc and HA/PLLA-spinal segments demonstrated segmental mobility at 15 and 24 months; however, the range of motion (ROM) in flexion-extension decreased to 49 and 40%, respectively, despite statistically equivalent preserved torsional ROM. Histologically there was excellent osseous fusion at the 3D fabric disc surface-vertebral body interface. At 2 years posttreatment, no adverse tissue reaction nor aseptic loosening of the device was observed. CONCLUSIONS: Intervertebral disc replacement with the 3D fabric disc was viable and when used in conjunction with the bioresorbable HA/PLLA spinal augmentation. Further refinements of device design to create a stand-alone type are necessary to obviate the need for additional spinal stabilization.

Published
2004

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