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Objective: Given the need for further studies on health-promoting behaviors, the present study aimed to investigate the antecedents of controlling risk factors for cardiovascular diseases (CVDs) according to the affective and emotional composite temperament (AFECT) model and the mediating role of self-regulation. Materials and Methods: The samples of this cross-sectional study included 776 people resident in Kermanshah in Western Iran in 2019. The participants were selected using a cluster sampling method. Data were collected using the controlling the risk factors for cardiovascular disease questionnaire (CRC), the short form self-regulation questionnaire, and the AFECT scale. The structural equation modeling was used to analyze the data. Results: The analysis results indicated that there was a significant correlation between dimensions of AFECT and self-regulation with the control of risk factors for CVDs. The results also indicated that the dimensions of AFECT did not directly affect the control of risk factors for CVDs, but the mediating role of self-regulation was confirmed in this regard. Conclusion: According to the results, the dimensions of AFECT could affect the control of risk factors for CVDs through self-regulation; hence, the role of self-regulation in controlling CVDs should be taken into account. [ABSTRACT FROM AUTHOR]