1. Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.
- Author
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Rigby KL, Diaz MJ, Gozlan EC, Kacsoh DB, Song JJ, Hudock TR, Chobrutskiy A, Chobrutskiy BI, and Blanck G
- Subjects
- Humans, Cytomegalovirus Infections immunology, Cytomegalovirus Infections virology, Prognosis, Epitopes immunology, Wilms Tumor immunology, Wilms Tumor genetics, Complementarity Determining Regions genetics, Complementarity Determining Regions immunology, Receptors, Antigen, T-Cell immunology, Receptors, Antigen, T-Cell genetics, Receptors, Antigen, T-Cell metabolism, Kidney Neoplasms immunology, Kidney Neoplasms genetics, Cytomegalovirus immunology
- Abstract
Background/aim: Wilms' tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival., Materials and Methods: We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms' tumor., Results: T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms' tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms' tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes., Conclusion: Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2024
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