Search

The paper describes a novel, simple servo drive position controller, using solely the knowledge about the structure of the nonlinear model and the constraints met by individual components of the model. The desired behavior of the position and velocity signals is obtained by imposing a time-varying constraint on the signal aggregating information about the position and velocity tracking errors. The method allows you to determine the maximum control (servo drive current) necessary to achieve the control goal under the existing initial conditions and the selected reference trajectory. The control is constrained and consists in appropriate reaction when the trajectory approaches the barrier, the shape of which is responsible for the imposed properties of the transient and quasi-steady state tracking error. In addition to the derivation of the control, a discussion of its possible variants and basic properties is presented. Control with time-varying constraints has been introduced, which allows the control objectives to be met with limited conservatism of the imposed constraints. The influence of technical factors related to actual speed and position measurements was discussed and the operation of the real drive on a laboratory stand was presented. [ABSTRACT FROM AUTHOR]

Copyright of Przegląd Elektrotechniczny is the property of Przeglad Elektrotechniczny and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The problem of practical synchronization of an uncertain Duffing oscillator with a higher order chaotic system is considered. Adaptive control techniques are used to obtain chaos synchronization in the presence of unknown parameters and bounded, unstructured, external disturbances. The features of the proposed controllers are compared by solving Duffing-Arneodo and Duffing-Chua synchronization problems.

We consider a two-mass drive with a flexible joint with a nonlinear characteristic of the transmitted torque as a function of the torsion angle. We propose a new, nonlinear, adaptive position-tracking controller, taking this nonlinearity of stiffness into account. The derivation of the controller is based on nonlinear adaptive control theory, incorporates several non-standard mathematical techniques and provides a proof of the uniform ultimate boundedness of tracking errors. As the result, we present a controller that solves the position tracking problem, attenuates dangerous tortional oscillations in the shaft and operates correctly in the presence of unknown torques acting on both sides of the joint, even if all plant parameters are unknown. We demonstrate experimentally that using some materials indeed introduces a nonlinear characteristic of the joint. We prove via real plant experiments that the proposed control algorithm is easily implementable with a DSP controller in real-world applications. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a progressive neurodegenerative brain disease. Thus, drugs including donepezil, rivastigmine, and galantamine are not entirely effective in the treatment of this multifactorial disease. The present study evaluates eight derivatives (3a–3h) as candidates with stronger anti-AD potential but with less side effects. Reactive oxygen species (ROS) assays were used to assess oxidative stress which involve in the neurodegeneration. The neuroprotective properties of 3e against oxidative stress were done in three experiments using MTT test. The anti-AD potential was determined based on their anticholinesterase inhibition ability, determined using Ellman's method, Aβ aggregation potential according to thioflavin (Th) fluorescence assay, and their antioxidative and anti-inflammatory activities. Compound 3e exhibited moderate cholinesterase inhibition activity (AChE, IC50 = 0.131 µM; BuChE, IC50 = 0.116 µM; SI = 1.13), significant inhibition of Aβ(1–42) aggregation (55.7%, at 5 µM) and acceptable neuroprotective activity. Extensive analysis of in vitro and in vivo assays indicates that new cyclopentaquinoline derivatives offer promise as candidates for new anti-AD drugs. [ABSTRACT FROM AUTHOR]

Objectives: Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes (XRCC1, OGG1 and MUTYH) and level of oxidative damage (measured as level of 8-oxo-guanine, 8-oG) on modulation of the risk of colorectal cancer.Material and Methods: In group of 324 patients with colorectal cancer the occurrence of polymorphic variants in Ser326Cys of OGG1, Arg399Gln of XRCC1 and Gln324His of MUTYH were studied with TaqMan technique. In addition level of 8-oG in isolated DNA was determined.Results: Studied polymorphisms of OGG1, XRCC1 and MUTYH genes influence the risk of CRC: OGG1 Ser326Cys (OR = 1.259, 95% CI: 1.058-1.499, p = 0.007), XRCC1 Arg399Gln (OR = 2.481, 95% CI: 1.745-3.529, p < 0.0001) and MUTYH Gln324His (OR = 1.421, 95% CI: 1.017-1.984, p = 0.039) increase the risk. At the same time, studies examined level of 8-oG for each of the genotypes in both the patient and control group, and have shown that OGG1 Ser326Cys and XRCC1 Arg399Gln are associated with elevated 8-oG level, while MUTYH Gln324His is not, suggesting, that in case of OGG1 Ser326Cys and XRCC1 Arg399Gln CRC risk modulation is connected to mechanisms associated with 8-oG levels.Conclusions: This work shows that patients with CRC not only have an increased level of 8-oG and that the studied polymorphisms modulate risk of cancer, but also indicate a relationship between these 2 phenomena, which may contribute to a better understanding of the mechanism of neoplastic process in case of reduced effectiveness of DNA repair mechanisms. Int J Occup Med Environ Health. 2022;35(5):625-33. [ABSTRACT FROM AUTHOR]

Introduction: Colorectal cancer (CRC), despite intensive research on the improvement of diagnosis and treatment, is still the second most deadly cancer in Poland in terms of mortality. One of the factors predisposing to a higher risk of CRC may be the individual differences in the effectiveness of proteins responsible for the metabolism of xenobiotics – it seems that the removal of potentially harmful exogenous substances significantly reduces the risk of carcinogenesis. Aim: In this work, we analyzed the effect of polymorphisms of genes responsible for metabolizing xenobiotics on the risk of CRC – rs72554606 polymorphism of NAT1 gene, rs1799930 polymorphism of NAT2 gene and rs1799814 polymorphism of CYP1A1 gene, as well as the level of expression of these genes. Conclusions: The results indicate that the GC genotype for NAT1 and the GA genotype for CYP1A1 may increase the risk of CRC, and in those already diagnosed with colorectal cancer, the expression level of NAT1 is significantly lower than in the control. We believe that these factors may have potential prognostic and diagnostic significance in the treatment of CRC. [ABSTRACT FROM AUTHOR]

Colorectal cancer (CRC) is one of the most common malignant tumors. One of the factors increasing the risk of its occurrence may be the reduced efficiency of repairing DNA damage, both nuclear and mitochondrial. The main mechanism for repairing oxidative damage is the BER system (in mitochondria mtBER), whose key proteins NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 obtain full efficiency only at the appropriate level of acetylation. Sirtuin 3 is a key protein for mitochondrial homeostasis, regulating a number of metabolic processes related mainly to the control of the level of reactive oxygen species. Because Sirt3 possesses acetylase activity, it can modulate the level of activity of mtBER proteins by their deacetylation. The conducted study showed that the tested proteins NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 are the substrate for the enzymatic deacetylation activity of Sirt3, which may lead to modulation of the risk of CRC, and in cancer cells may be a potential therapeutic target enhancing the action of cytostatic drugs. [ABSTRACT FROM AUTHOR]