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2. Misclassification of carotid stenosis severity with area stenosis-based evaluation by computed tomography angiography: impact on erroneous indication to revascularization or patient (lesion) migration to a higher guideline recommendation class as per ESC/ESVS/ESO/SVS and CMS-FDA thresholds

Author

Lukasz Tekieli, Adam Mazurek, Karolina Dzierwa, Justyna Stefaniak, Anna Kablak-Ziembicka, Magdalena Knapik, Zbigniew Moczulski, R. Pawel Banys, Malgorzata Urbanczyk-Zawadzka, Wladyslaw Dabrowski, Maciej Krupinski, Piotr Paluszek, Ewa Weglarz, Łukasz Wiewiórka, Mariusz Trystula, Tadeusz Przewlocki, Piotr Pieniazek, and Piotr Musialek

Subjects
carotid stenosis severity, percentage stenosis, computed tomography angiography, catheter angiography, area stenosis, diameter stenosis, Medicine
Published
2023
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3. Imaging modality-dependent carotid stenosis severity variations against intravascular ultrasound as a reference: Carotid Artery intravasculaR Ultrasound Study (CARUS)

Author

Tekieli, Lukasz, primary, Kablak-Ziembicka, Anna, additional, Dabrowski, Wladyslaw, additional, Dzierwa, Karolina, additional, Moczulski, Zbigniew, additional, Urbanczyk-Zawadzka, Malgorzata, additional, Mazurek, Adam, additional, Stefaniak, Justyna, additional, Paluszek, Piotr, additional, Krupinski, Maciej, additional, Przewlocki, Tadeusz, additional, Pieniazek, Piotr, additional, and Musialek, Piotr, additional

Published
2023
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5. Association of Increased Vascular Stiffness with Cardiovascular Death and Heart Failure Episodes Following Intervention on Symptomatic Degenerative Aortic Stenosis

Author

Jakub Baran, Anna Kablak-Ziembicka, Pawel Kleczynski, Ottavio Alfieri, Łukasz Niewiara, Rafał Badacz, Piotr Pieniazek, Jacek Legutko, Krzysztof Zmudka, Tadeusz Przewlocki, and Jakub Podolec

Subjects
vascular stiffness, cardiovascular death, degenerative aortic stenosis, heat failure episodes, pulsatile index, resistive index, Medicine
Abstract

Background. The resistive (RI) and pulsatile (PI) indices are markers of vascular stiffness (VS) which are associated with outcomes in patients with cardiovascular disease. We aimed to assess whether VS might predict incidence of cardiovascular death (CVD) and heart failure (HF) episodes following intervention on degenerative aortic valve stenosis (DAS). Methods. The distribution of increased VS (RI ≥ 0.7 and PI ≥ 1.3) from supra-aortic arteries was assessed in patients with symptomatic DAS who underwent aortic valve replacement (AVR, n = 127) or transcatheter aortic valve implantation (TAVI, n = 119). During a 3-year follow-up period (FU), incidences of composite endpoint (CVD and HF) were recorded. Results. Increased VS was found in 100% of TAVI patients with adverse event vs. 88.9% event-free TAVI patients (p = 0.116), and in 93.3% of AVR patients with event vs. 70.5% event-free (p = 0.061). Kaplan–Mayer free-survival curves at 1-year and 3-year FU were 90.5% vs. 97.1 % and 78% vs. 97.1% for patients with increased vs. lower VS. (p = 0.014). In univariate Cox analysis, elevated VS (HR 7.97, p = 0.04) and age (HR 1.05, p = 0.024) were associated with risk of adverse outcomes; however, both failed in Cox multivariable analysis. Conclusions. Vascular stiffness is associated with outcome after DAS intervention. However, it cannot be used as an independent outcome predictor.

Published
2022
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7. Automatic identification of variables in epidemiological datasets using logic regression.

Author

Matthias W. Lorenz, Negin Ashtiani Abdi, Frank Scheckenbach, Anja Pflug, Alpaslan Bülbül, Alberico L. Catapano, Stefan Agewall, Marat Ezhov, Michiel L. Bots, Stefan Kiechl, Andreas Orth, Giuseppe D. Norata, Jean Philippe Empana, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R. Srinivasan, Lars Lind, Akihiko Kato, Chrystosomos Dimitriadis, Tadeusz Przewlocki, Shuhei Okazaki, Coen D. A. Stehouwer, Tatjana Lazarevic, Peter Willeit, David N. Yanez, Helmuth Steinmetz, Dirk Sander, Holger Poppert, Moise Desvarieux, Mohammad Arfan Ikram, Sebastjan Bevc, Daniel Staub, Cesare R. Sirtori, Bernhard Iglseder, Gunnar Engström, Giovanni Tripepi, Oscar Beloqui, Moo-Sik Lee, Alfonsa Friera, Wuxiang Xie, Liliana Grigore, Matthieu Plichart, Ta-Chen Su, Christine Robertson, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Völzke, Giel Nijpels, Aleksandar Jovanovic, Johann Willeit, Ralph L. Sacco, Oscar H. Franco, Radovan Hojs, Heiko Uthoff, Bo Hedblad, Hyun Woong Park, Carmen Z. Suarez, Dong Zhao, Pierre Ducimetiere, Kuo-Liong Chien, Jackie F. Price, Göran Bergström, Jussi Kauhanen, Elena Tremoli, Marcus Dörr, Gerald Berenson, Aikaterini Papagianni, Anna Kablak-Ziembicka, Kazuo Kitagawa, Jaqueline M. Dekker, Radojica Stolic, Joseph F. Polak, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Robert Ekart, Beat Frauchiger, Samuela Castelnuovo, Maria Rosvall, Carmine Zoccali, Manuel F. Landecho, Jang-Ho Bae, Rafael Gabriel, Jing Liu, Damiano Baldassarre, and Maryam Kavousi

Published
2017
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8. Imaging modality-dependent carotid stenosis severity variations against intravascular ultrasound as a reference: Carotid Artery intravasculaR Ultrasound Study (CARUS)

Author

Tekieli, Lukasz, primary, Kablak-Ziembicka, Anna, additional, Dabrowski, Wladyslaw, additional, Dzierwa, Karolina, additional, Moczulski, Zbigniew, additional, Urbanczyk-Zawadzka, Malgorzata, additional, Mazurek, Adam, additional, Stefaniak, Justyna, additional, Krupinski, Maciej, additional, Przewlocki, Tadeusz, additional, Odrowaz-Pieniazek, Piotr, additional, and Musialek, Piotr, additional

Published
2022
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9. Imaging modality-dependent carotid stenosis severity variations against intravascular ultrasound as a reference: Carotid Artery intravasculaR Ultrasound Study (CARUS)

Author

Lukasz Tekieli, Anna Kablak-Ziembicka, Wladyslaw Dabrowski, Karolina Dzierwa, Zbigniew Moczulski, Malgorzata Urbanczyk-Zawadzka, Adam Mazurek, Justyna Stefaniak, Maciej Krupinski, Tadeusz Przewlocki, Piotr Odrowaz-Pieniazek, and Piotr Musialek

Abstract

Purpose Different non-invasive and invasive imaging modalities are used to determine carotid artery stenosis severity as a principal parameter in clinical decision-making. We compared stenosis degree obtained with different modalities against intravascular ultrasound (IVUS). Methods 300 consecutive patients (age 47–83 years, 192 men, 68% symptomatic) with carotid artery stenosis of “≥50%” referred for potential revascularization received as per study protocol (i) duplex ultrasound (DUS), (ii) computed tomography angiography (CTA), (iii) invasive quantitative angiography (iQA) and (iv) the vascular imaging gold standard, IVUS. Correlation of measurements with IVUS (r), proportion of those concordant (within 10%) and proportion of under/overestimated were calculated along with recipient-operating-characteristics (ROC). Results For IVUS area stenosis (AS) and IVUS minimal lumen area (MLA), there was only a moderate correlation with DUS velocities (peak-systolic, PSV; end-diastolic, EDV; r values of 0.42–0.51, p

Published
2022

11. Association of Increased Vascular Stiffness with Cardiovascular Death and Heart Failure Episodes Following Intervention on Symptomatic Degenerative Aortic Stenosis

Author

Baran, Jakub, primary, Kablak-Ziembicka, Anna, additional, Kleczynski, Pawel, additional, Alfieri, Ottavio, additional, Niewiara, Łukasz, additional, Badacz, Rafał, additional, Pieniazek, Piotr, additional, Legutko, Jacek, additional, Zmudka, Krzysztof, additional, Przewlocki, Tadeusz, additional, and Podolec, Jakub, additional

Published
2022
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12. Misclassification of carotid stenosis severity with area stenosis-based evaluation by computed tomography angiography: impact on erroneous indication to revascularization or patient (lesion) migration to a higher guideline recommendation class as per ESC/ESVS/ESO/SVS and CMS-FDA thresholds

Author

Lukasz Tekieli, Adam Mazurek, Karolina Dzierwa, Justyna Stefaniak, Anna Kablak-Ziembicka, Magdalena Knapik, Zbigniew Moczulski, R. Pawel Banys, Malgorzata Urbanczyk-Zawadzka, Wladyslaw Dabrowski, Maciej Krupinski, Piotr Paluszek, Ewa Weglarz, Łukasz Wiewiórka, Mariusz Trystula, Tadeusz Przewlocki, Piotr Pieniazek, and Piotr Musialek

Subjects
Cardiology and Cardiovascular Medicine
Published
2022

13. Misclassification of carotid stenosis severity with area stenosis-based evaluation by computed tomography angiography: impact on erroneous indication to revascularization or patient (lesion) migration to a higher guideline recommendation class as per ESC/ESVS/ESO/SVS and CMS-FDA thresholds

Author

Tekieli, Lukasz, primary, Mazurek, Adam, additional, Dzierwa, Karolina, additional, Stefaniak, Justyna, additional, Kablak-Ziembicka, Anna, additional, Knapik, Magdalena, additional, Moczulski, Zbigniew, additional, Banys, R. Pawel, additional, Urbanczyk-Zawadzka, Malgorzata, additional, Dabrowski, Wladyslaw, additional, Krupinski, Maciej, additional, Paluszek, Piotr, additional, Weglarz, Ewa, additional, Wiewiórka, Łukasz, additional, Trystula, Mariusz, additional, Przewlocki, Tadeusz, additional, Pieniazek, Piotr, additional, and Musialek, Piotr, additional

Published
2022
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14. P5.18 TRANSRADIAL APPROACH FOR VERTEBRAL ARTERY STENTING: SINGLE-CENTER EXPERIENCE

Author

Damian Maciejewski, Lukasz Tekieli, Anna Kablak-Ziembicka, Karolina Dzierwa, Piotr Paluszek, Andrzej Brzychczy, Grzegorz Lewinski, Magdalena Wojcik-Pedziwiatr, Roman Machnik, and Piotr Pieniazek

Subjects
Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objectives: Transradial vertebral artery (VA) angioplasty might be a viable alternative to the transfemoral approach in cases of peripheral artery disease or anatomical variations of the aortic arch. The purpose of our study was to evaluate the safety and efficacy of transradial stenting of symptomatic VA stenosis. Material and methods: Seventeen patients [67±8,4 years, 76% men, with >80% stenosis, 13 right-side, all symptomatic from posterior circulation (history of stroke, TIA or chronic ischemic symptoms)] with peripheral artery disease (PAD) or unsuccessful attempt via femoral access were scheduled for VA angioplasty by radial approach. Clinical and duplex ultrasound (DUS) follow-up were performed before discharge and 6, 12 and 24 months after VA stenting. Results: The technical success rate was 100%. In all cases VA angioplasty was performed with the use of single balloon-mounted stent (11 bare metal stents, 6 drug eluting stents). The mean NASCET VA stenosis was reduced from 87,5% to 5,9% (p

Published
2015
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15. P5.19 TRANSRADIAL APPROACH FOR CAROTID ARTERY STENTING: SINGLE-CENTER EXPERIENCE

Author

Damian Maciejewski, Lukasz Tekieli, Anna Kablak-Ziembicka, Piotr Paluszek, Mariusz Trystula, Karolina Dzierwa, Magdalena Wojcik-Pedziwiatr, Roman Machnik, Grzegorz Lewinski, and Piotr Pieniazek

Subjects
Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objectives: The transfemoral approach is commonly used for carotid artery stenting (CAS) however in cases of severe peripheral vascular disease or unfavorable aortic arch anatomy, the transradial access remains a viable alternative. We report a series of patients with aorto-iliac disease or unsuccessful attempt via femoral access in whom transradial carotid artery stenting was performed. Material and methods: Sixteen patients (69±10,7 years, 75%men, with >70% stenosis, 10 left-side, 5 contralateral carotid occlusion, 9 with history of stroke or TIA) with peripheral artery disease (PAD) or unsuccessful attempt via femoral access were scheduled for carotid artery angioplasty by radial approach. Clinical and duplex ultrasound (DUS) follow-up were performed before discharge and 1, 12 and 24 months after carotid artery stenting. Results: The technical success rate was 87,5%. In two cases attempt via femoral and radial access were unsuccessful and the patients were treated by endarterectomy. In other cases CAS was performed with self-expanding bare metal stents. The mean NASCET carotid artery stenosis was reduced from 85% to 9,6% (p

Published
2015
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16. Special Issue 'The Prevention and Treatment of Atherosclerosis'

Author

Anna Kablak-Ziembicka

Subjects
General Medicine
Abstract

This editorial summarizes the 10 scientific papers that contributed to the Special Issue of the Journal of Clinical Medicine: ‘The Prevention and Treatment of Atherosclerosis’ [...]

Published
2022

31. Poster Session 1The imaging examination and quality assessmentP185Why did the normal values of the left and right atrial volumes increase in the recent chamber quantification guidelines update?P186Atrial electromechanical delay, Left Atrial mechanical functions and longitudinal left ventricular strain in pre-diabetic patientsP187A web-based platform for e-training in echocardiographyP188Righ atrial size as a marker of success in electrical cardioversion in patients with persistent atrial fibrillationP189Echocardiographic assessment of left atrial dimensions and function in a healthy populationP190Impact of carotid artery revascularization on the cognitive and functional outcome and cerebral flow on TCD and brain MRI in patients with symptomatic carotid artery stenosis: a preliminary reportP191Aortic elasticity is impaired in hypereosinophilic syndromeP192Disturbed intracardiac flow transit prognosticates early decompensation in dilated cardiomyopathyP193Ultrasound guided treatment in acute heart failureP194Determinants of impaired global longitudinal function in middle-aged subjects free of cardiovascular diseaseP195Left ventricular remodeling in asymptomatic heart failure: classification and prognostic evaluationP196Restricted displacement of lateral right ventricular wall: a physiopathological explanation of geometrical and functional cardiac changes after cardiac surgeryP197A novel method to image intracardiac flow stagnation for the risk stratification for thrombosisP198Magnetic resonance imaging of anomalous origin of the left coronary artery from the pulmonary artery in children older than 4 monthsP199Coronary flow reserve is improved by LDL apheresis in patients with familial hypercholesterolemia and chronic ischemic heart diseaseP200 High velocities in the proximal part of the coronary arteries during routine echocardiography can predict nearest prognosisP201Recovery potential of the right ventricular function in the setting of a first STEMI treated by primary PCI: an echocardiographic studyP202Severe aortic stenosis patients with preserved ejection fraction according to flow and gradient classification: prevalence and outcomesP203Is basal left ventricular ejection time able to predict the severity of aortic stenosis in patients with depressed ejection fraction?P204Acceleration time in aortic stenosis: a new echocardiographic diagnostic parameterP205Application of novel Doppler indices of stenosis severity in the assessment of rheumatic mitral stenosis beyond conventional valve area and transvalvular gradientsP206Comparison of conventional echo score in patients with symptomatic rheumatic mitral stenosis: transesophageal echocardiography versus transthoracic echocardiographyP207Speckle-tracking echocardiography in evaluation early left ventricular systolic dysfunction in asymptomatic aortic regurgitation patients with good left ventricular ejection fractionP208Expansible aortic ring annuloplasty: mid-term results of aortic valve repairP209Papillary muscle dysfunction: insights into mitral valve prolapse using speckle tracking imaging

Author

L. Ring, Z. Hlubocka, V. Mizariene, YH. Park, A. Chong, D. Ruiz Fernandez, AS. Lazaro Mendes, JM. Monteagudo Ruiz, M. Stoian, A. Zagatina, E. Pasanisi, AJR Jurko, H. Nishikawa, A. Garcia Martin, I. Fabiani, I. Ceponiene, J. Oehman, T. Uejima, A. Nemes, R. Badacz, R W J Van Grootel, C. Doering, R. Conte, TAMER Moustafa, K. Kebed, E. Kruse, K. Addetia, B. Ciszek, M. Thykattil, B. Guile, RM. Lang, V. Mor-Avi, RAGAB Mahfouz, AHMED Elzayat, MOHAMD Goda, MARWA Gad, F. Sansone, F. Napoli, A. Tonacci, M. Raciti, P. Landi, A. Grande, L. Ait-Ali, K. Sveric, U. Richter, RH. Strasser, C. Wunderlich, ME. Menting, JS. Mcghie, M. Strachinaru, WB. Vletter, ML. Geleijnse, JW. Roos-Hesselink, AE. Van Den Bosch, A. Kablak-Ziembicka, M. Urbanczyk-Zawadzka, RP. Banys, P. Musialek, P. Pieniazek, S. Mleczko, K. Zmudka, T. Przewlocki, I. Marton, P. Domsik, A. Kalapos, E. Posfai, S. Modok, Z. Borbenyi, T. Forster, L. Takahashi, H. Semba, H. Sawada, T. Yamashita, R. Jurkevicius, J. Petkeviciene, O. Gustiene, E. Tamuleviciute-Prasciene, J. Motiejunaite, R. Slapikas, NR. Pugliese, S. La Carrubba, F. Antonini Canterin, P. Colonna, P. Caso, F. Benedetto, R. Citro, S. Carerj, V. Di Bello, JL. Moya Mur, C. Lazaro Rivera, LM. Rincon Diaz, J. Miguelena Hycka, A. Garcia Lledo, JJ. Jimenez Nacher, C. Fernandez-Golfin, J. Rodriguez-Roda, JL. Zamorano, A. Jurko, T. Jurko, J. Mistinova-Polakova, F. Sbrana, C. Petersen, F. Bigazzi, B. Dal Pino, M. Coceani, A. Ripoli, M. Pianelli, R. Luciani, T. Sampietro, N. Zhuravskaya, Y. Vareldzhyan, M. Kamenskikh, D. Shmatov, D. Zamfir, A. Vijiiac, D. Pitic, G. Tamasescu, S. Onciul, R. Onut, C. Stefan, M. Dorobantu, A. Gonzalez-Gomez, C. Izurieta, A. Marco, GL. Alonso Salinas, R. Hinojar Baydes, E. Casas Rojo, AR. Ferreira, J. Moura Ferreira, L. Leite, AP. Oliveira, N. Ribeiro, AJ. Barbosa, R. Mata Martins, D. Ramos, M. Pego, S. Gamaza Chulian, E. Diaz Retamino, S. Camacho Freire, A. Gutierrez Barrios, J. Oneto Otero, M. Bansal, HK. Grewal, RR. Kasliwal, S. Wahi, SH. Lee, DS. Lee, JM. Hwang, JS. Kim, JH. Kim, KJ. Chun, M. Bieseviciene, R. Verseckaite, R. Jonkaitiene, J. Janenaite, G. Dostalova, J. Hlubocky, R. Novotny, V. Vondracek, J. Lindner, A. Linhart, and NK. Preston

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine, Follow up studies, Radiology, Nuclear Medicine and imaging, Regression analysis, General Medicine, Longitudinal function, Disease, Cardiology and Cardiovascular Medicine, business, Cohort study
Published
2016

35. The role of chemokine CCL5/RANTES and metalloproteinase-9 as inflammatory modulators in symptomatic internal carotid artery stenosis

Author

R, Badacz, J, Podolec, T, Przewlocki, M, Siedlinski, E, Jozefczuk, H, Oleksy, J, Baran, P, Pieniazek, K, Zmudka, and A, Kablak-Ziembicka

Subjects
Aged, 80 and over, Male, Risk, Matrix Metalloproteinase 9, Myocardial Ischemia, Cytokines, Humans, Carotid Stenosis, Female, Inflammation Mediators, Middle Aged, Plaque, Atherosclerotic, Aged
Abstract

Up to 80% of all ischemic strokes (IS) attributed to internal carotid athero-occlusive artery stenosis (ICAS) are related to a thromboembolic mechanism. One athero-occlusive ischemic event increases the risk for ischemia in another vascular territory, resulting from inflammation within the atherosclerotic plaque induced by cytokines. Thus, ultrasonographic characteristics of vulnerable plaques in ICAS, including plaque echolucency and ulceration might correspond to cytokine activity. The present study aimed to investigate the associations between serum cytokines and atherosclerotic plaque characteristics and the 3-year risk of a major adverse coronary and carotid ischemic event (MACCE) in symptomatic patients treated for ICAS. Plaque characteristics on ultrasonography, serum levels of C-C motif chemokine ligand 5 (CCL5)/regulated on activation, normal T-cell expressed and secreted (RANTES), metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), transforming growth factor beta (TGF-β), C-X-C motif chemokine ligand 16 (CXCL16), FAS ligand (FASL) and high sensivity C-reactive protein (hs-CRP) were analyzed in 103 symptomatic patients with ICAS prior to carotid revascularization. The incidence of MACCE: cardiovascular death (CVD), myocardial infarction (MI) and recurrent ischemic stroke (IS) were recorded prospectively for up to 5 years (median 37; IQR 21 - 40 months). Echolucent plaques, in comparison to echogenic plaques, displayed lower median levels of RANTES (P = 0.042) but higher median levels of IL-6 (P = 0.039). There was no relationship between plaque characteristics and median levels of MMP-9, TGF β, CXCL16, FASL, or hs-CRP (P = NS). During follow-up, MACCE occurred in 15 (14.6%) patients. Univariate Cox proportional hazard analysis indicated median RANTES levels45.5ng/mL (hazard ratio (HR) = 3.95; 95%CI = 1.10 - 14.2; P = 0.035), MMP-90.6 μg/mL (HR 4.5; 95%CI = 1.4 - 13.9; P = 0.009), renal impairment (HR 3.48; 95%CI = 1.29 - 9.34; P = 0.013) as potential MACCE risk factors. On multivariate Cox proportional hazard analysis, MMP-90.6 μg/mL and RANTES45.5 ng/ml were associated with a 4.72-fold (95%CI = 1.3 - 17.0; P = 0.017) and a 3.8-fold risk increase (95%CI = 1.07 - 13.89; P = 0.038) of MACCE. Kaplan-Meier analysis showed significant differences in MACCE-free survival rates depending on RANTES and MMP-9 median levels. We conclude that serum RANTES, IL-6, and MMP-9 were associated with plaque vulnerability and predicted adverse MACCE in patients treated for ICAS.

Published
2019

43. Serum rantes, transforming growth factor-β1 and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis

Author

J, Podolec, J, Baran, M, Siedlinski, M, Urbanczyk, M, Krupinski, K, Bartus, L, Niewiara, M, Podolec, T, Guzik, L, Tomkiewicz-Pajak, M, Komar, and A, Kablak-Ziembicka

Subjects
Male, Interleukin-6, Myocardium, Heart, Aortic Valve Stenosis, Middle Aged, Fibrosis, Magnetic Resonance Imaging, Ventricular Function, Left, Transforming Growth Factor beta1, Echocardiography, Humans, Female, Chemokine CCL5, Aged
Abstract

Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation and immune-cell recruitment. Interleukin -6 (IL-6) is used as a general index of severity of the chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) is an immune biomarker potentially involved in the regulation of valve fibrosis and calcification. The aim of this study was to analyze selected biomarkers associated with the different stages of immune-pathogenesis in aortic stenosis. Forty consecutive patients with moderate to severe aortic stenosis (AS) and without previous myocardial infarction history were included in the study and divided into two groups. Two imaging techniques, echocardiography and magnetic resonance, were used to estimate the degree of AS and left ventricular muscle function. Inflammatory biomarker serum levels including CCL5/RANTES, IL-6, and TGF-β1 were determined based on ELISA measurements. Mean levels of RANTES, IL-6, and TGF-β1 did not significantly differ between both groups. A negative correlation was found between RANTES serum level and left ventricle (LV) mass as assessed by MRI (r = -0.3358, P = 0.0341). A positive correlation (r = 0.3283, P = 0.0387) was found between IL-6 serum levels and LV mass as measured by MRI. In addition, a positive correlation (r = 0.6803, P = 0.01) was seen between IL-6 serum levels and LV muscle mass with positive late gadolinium enhancement (LGE). There was a positive correlation between TGF-β1 serum level and ejection fraction as measured by echocardiography (r = 0.3217, P = 0.043). The relationship between selected inflammatory biomarkers, LV ejection fraction, LV mass, and LV muscle mass with LGE appeared to be independent of valvular pathobiologic process severity, as we did not observe differences in IL-6, RANTES, or TGF-β1 between groups differing in severity. On the contrary, these markers appear to be linked to myocardial function and remodeling, which may provide valuable insights into the pathobiology of AS and provide a basis for future detection strategies of AS.

Published
2018

45. Higher levels of circulating naïve CD8

Author

Jakub, Podolec, Lukasz, Niewiara, Dominik, Skiba, Mateusz, Siedlinski, Jakub, Baran, Monika, Komar, Bartlomiej, Guzik, Anna, Kablak-Ziembicka, Grzegorz, Kopec, Tomasz, Guzik, Krzysztof, Bartus, Wojciech, Plazak, and Krzysztof, Zmudka

Subjects
Adult, Aged, 80 and over, CD4-Positive T-Lymphocytes, Male, Humans, Leukocyte Common Antigens, Female, Coronary Artery Disease, Endothelium, Vascular, Middle Aged, Pulse Wave Analysis, Aged
Published
2017

46. Automatic identification of variables in epidemiological datasets using logic regression

Author

Lorenz, Matthias W., Abdi, Negin Ashtiani, Scheckenbach, Frank, Pflug, Anja, Bülbül, Alpaslan, Catapano, Alberico L., Agewall, Stefan, Ezhov, Marat, Bots, Michiel L., Kiechl, Stefan, Orth, Andreas, Norata, Giuseppe D., Empana, Jean Philippe, Lin, Hung Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Kato, Akihiko, Dimitriadis, Chrystosomos, Przewlocki, Tadeusz, Okazaki, Shuhei, Stehouwer, C. D.A., Lazarevic, Tatjana, Willeit, Peter, Yanez, David N., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Bevc, Sebastjan, Staub, Daniel, Sirtori, Cesare R., Iglseder, Bernhard, Engström, Gunnar, Tripepi, Giovanni, Beloqui, Oscar, Lee, Moo Sik, Friera, Alfonsa, Xie, Wuxiang, Grigore, Liliana, Plichart, Matthieu, Su, Ta Chen, Robertson, Christine, Schmidt, Caroline, Tuomainen, Tomi Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Jovanovic, Aleksandar, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Hojs, Radovan, Uthoff, Heiko, Hedblad, Bo, Park, Hyun Woong, Suarez, Carmen, Zhao, Dong, Catapano, Alberico, Ducimetiere, Pierre, Chien, Kuo Liong, Price, Jackie F., Bergström, Göran, Kauhanen, Jussi, Tremoli, Elena, Dörr, Marcus, Berenson, Gerald, Papagianni, Aikaterini, Kablak-Ziembicka, Anna, Kitagawa, Kazuo, Dekker, Jaqueline M., Stolic, Radojica, Polak, Joseph F., Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Ekart, Robert, Frauchiger, Beat, Castelnuovo, Samuela, Rosvall, Maria, Zoccali, Carmine, Landecho, Manuel F., Bae, Jang Ho, Gabriel, Rafael, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, APH - Health Behaviors & Chronic Diseases, AII - Infectious diseases, APH - Aging & Later Life, and Epidemiology

Subjects
Carotid Artery Diseases, Matching (statistics), Databases, Factual, Epidemiologic Factors, Computer science, Epidemiology, Sample (statistics), Health Informatics, Logistic regression, computer.software_genre, lcsh:Computer applications to medicine. Medical informatics, Data management, Carotid Intima-Media Thickness, Set (abstract data type), 03 medical and health sciences, 0302 clinical medicine, Meta-Analysis as Topic, Backup, Predictive Value of Tests, Statistics, Journal Article, Data Mining, Humans, 030212 general & internal medicine, Medical Informatics Applications, Health Policy, Prognosis, Logic regression, Computer Science Applications, Identification (information), Variable (computer science), Meta-analysis, Logistic Models, 030220 oncology & carcinogenesis, Data quality, lcsh:R858-859.7, Data mining, computer, Algorithms, Research Article
Abstract

Background For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this can be a time-consuming and error-prone task. Automated or semi-automated identification of variables can help to reduce the workload and improve the data quality. For semi-automation high sensitivity in the recognition of matching variables is particularly important, because it allows creating software which for a target variable presents a choice of source variables, from which a user can choose the matching one, with only low risk of having missed a correct source variable. Methods For each variable in a set of target variables, a number of simple rules were manually created. With logic regression, an optimal Boolean combination of these rules was searched for every target variable, using a random subset of a large database of epidemiological and clinical cohort data (construction subset). In a second subset of this database (validation subset), this optimal combination rules were validated. Results In the construction sample, 41 target variables were allocated on average with a positive predictive value (PPV) of 34%, and a negative predictive value (NPV) of 95%. In the validation sample, PPV was 33%, whereas NPV remained at 94%. In the construction sample, PPV was 50% or less in 63% of all variables, in the validation sample in 71% of all variables. Conclusions We demonstrated that the application of logic regression in a complex data management task in large epidemiological IPD meta-analyses is feasible. However, the performance of the algorithm is poor, which may require backup strategies.

Published
2017

48. Determinants of long-term outcome in patients after percutaneous stent-assisted management of symptomatic subclavian or innominate artery stenosis or occlusion

Author

Przewlocki, Tadeusz, primary, Wrotniak, Leszek, additional, Kablak-Ziembicka, Anna, additional, Pieniazek, Piotr, additional, Roslawiecka, Agnieszka, additional, Rzeznik, Daniel, additional, Misztal, Marcin, additional, Zajdel, Wojciech, additional, Badacz, Rafal, additional, Sokolowski, Andrzej, additional, Trystula, Mariusz, additional, Musialek, Piotr, additional, and Zmudka, Krzysztof, additional

Published
2017
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49. Poster session Friday 7 December - PM: Effect of systemic illnesses on the heart

Author

G. Forleo, T. Henriques-Coelho, A. Kalogerakis, A. Nestoruc, R. Conti, G. Guzman Martinez, M. Ostojic, S. Aytekin, P. Margetis, D. Kremastinos, A. Hagege, M. Sunbul, L. Hazarapetyan, M. Fernandes, A. Pfuetzner, M. Akkaya, I. Paraskevaides, C. Zito, F. Castillo, D. G. Dorado, A Di Cori, O. Azevedo, M. Pizzarelli, TM Li Causi, A. Jaccard, A. Chilingaryan, A. Lourenco, B. Mutlu, E. Ermis, M. Martinek, D. Duval, L. Tumasyan, J. Thambo, P. Virot, P. De Araujo Goncalves, I. Sari, F. Colazzo, A. Stepura, M. S. Carvalho, B. Beleslin, P. Nihoyannopoulos, A. Corciu, E. Langesaeter, F. Kyndt, J. Schott, A. Diogo, G. Andersen, D. De Palma, H. Skulstad, P. Crea, S. Wirdeier, M. Olszowska, S. Castelvecchio, M. Muiesan, M. Kalantzi, G. Ertas, K. Branidou, I. Alvarez Pichel, E. Shkolnik, T. Schuster, M. J. Monaghan, A. Parkhomenko, V. Schiano Lomoriello, A. Ahmed, C. Jimenez Rubio, M. M. Urdaniz, A. M. Lesniak-Sobelga, G. Rubagotti, S. Gustavsson, Verena Stangl, F. Bertacchini, J. Otterstad, S. Matsushita, G. Macri, W. Streb, C. David, Y. Nogami, L. Faber, J. Kim, M. Chigira, M. Cusma-Piccione, S.-H. Shin, Cristina Maria Stanescu, M. Hlawaty, C. Napolitano, T. Kaier, S. Yurdakul, A. E. Masip, A. Zacharaki, S. Adawi, L. Menicanti, L. Tomkiewicz-Pajak, A. Patrianakos, S. Ercan, J. Stepanovic, F. Matei, U. Richter, E. Erdogan, R. Shaikh, A. Kepez, E. Soldati, K. Jarosz, M. Miceli, J. Grapsa, M. Cardoso, L. Boubrit, J. Singelton, M. Morenate, Henryk Dreger, I. Comanescu, L. Fontana, S. Morner, C. Agabiti Rosei, L. Brodin, J. Vaskelyte, E. Hamodraka, K. Uno, Fabian Knebel, R. Petraco, M. Komeda, L. Weinert, I. Daha, A. Shiran, V. Stinziani, I. Asmer, F. Antonini-Canterin, L. Iliuta, M. Rosca, P. Lindqvist, N. Cortez-Dias, E. Mueller, Z. Katidis, Y. Vasyuk, P. Rubis, R. Jonkaitiene, J. G. Acosta Velez, S. Lafitte, K. Fox, T. Rakowski, C. Manisty, D. Stassaldi, R. Piazza, L. Spinelli, S. Han, R. Lang, L. Oreto, T. Le Tourneau, L. Li, J. Areias, R. Isnard, D. Silva, Karl Stangl, T. Kukulski, M. Gaspari, A. Tsatsopoulou, Miguel Mota Carmo, P. Pugliatti, A. Atsumi, J. Hammel, J. B. Rius, F. D'auria, O. Ozer, A. Comaglio, Giulio Zucchelli, R. Sicari, P. Claus, D. Horstkotte, A. Di Molfetta, J. De La Hera Galarza, P. Wathen, M. Ganaeem, E. Nyktari, G. Alongi, N. Hayashi, L. Castiglioni, C. El Hamel, A. Melidonis, Y. Seo, M. Cogne, C. Corros, F. Procaccio, L. Fresiello, T. Graven, D. De Guillebon, I. Machado, V. Mor-Avi, R. Rubinshtein, E. Durmus, A. Venkatesh, A. Paini, E. Truemper, A. Aleixo, A. Sahlen, C. Wunderlich, H. Uyarel, R. Ippolito, J. Huhta, D. Morgan, M. Petrovic, G. Cole, C. Piper, N. Zhuravskaya, J. Dubiel, R. Bloise, A. Iniesta Manjavacas, J. Kleinau, J. Lambert Rodriguez, E. Pasanisi, V. Petitalot, D. Beldekos, H. Lim, P. Kleczynski, N. Echahidi, K. Linask, A. Tasal, U. Guerrini, B. Haugen, V. Pereira, M. Banovic, A. Moreo, J. Miralles Ibarra, J F Rodriguez Palomares, C. Park, O. Mjolstad, R. Levine, M. T. G. Alujas, A. Zagatina, M. Martin Fernandez, J. Voigt, E. Psathakis, Y.-Y. Yang, B. Smith, A. Marciniak, T. Yoshikawa, M. Mohammed, C. Aggiusti, H. Tountas, M. Montoro Lopez, M. Guazzi, T. Przewlocki, D. Kim, A. Vannozzi, P. Kogoj, A. Kablak-Ziembicka, S. Goncalves, P. Heilmeyer, S. Censi, J. Kwan, S. Crispo, I. Nogueira, G. Isasti Aizpurua, F. Parthenakis, K. Sveric, O. Uku, F. Anglano, R. Jozwa, A. Karamanou, B. Ozben, M. Delgado, A. Santoro, A. Scafa Udriste, B. Vujisic-Tesic, Y. Kameda, L. Mathias, M. Bongiorni, S. Gianstefani, K.-S. Hsieh, J. Cousins, M. Prull, M. Isailovic-Kekovic, M. Turfan, J. Reiken, R. Muscariello, O. Fernandez Cimadevilla, E. Tremoli, S. Gherardi, F. Musca, S. Kutty, B. Popovic, D. Dudek, L. Gullestad, Michael Laule, A. Almeida, S. Vrakas, C. Santoro, M. Moreno Yanguela, V. Nesvetov, I. Lekakis, V. Mizariene, H. Yamagata, I. Karch, C. Davos, E. Stepien, E. A. Di Panzillo, C. Morisco, S. Kim, M. Takeuchi, R. Del Bene, A. Gaspar, C. Choi, M. Duprey, C. Cefalu, P. Regnier, Q. Ciampi, D. Francis, Gerd Baldenhofer, J. Trochu, A. Dziewierz, T. Bombardini, I. Nedeljkovic, O. Tautu, O. Suhr, M. Enomoto, K.-P. Weng, E. Enache, J. Johnson, J. Legutko, S. Grigoryan, R. Winter, J. Sousa, K. Aonuma, G. Wulf, S. Priori, J. Attebery, A. Squeri, S. Bosi, D. Lavergne, F. Bandera, P. T. Mas, X. Iriart, P. Vardas, A. Brzozowska-Czarnek, B. Trimarco, J. Kasprzak, K. Stuuer, R. Arena, J. O. Na, E. Picano, A. Horovitz, M. Sucu, M. Vatankulu, Vasile Manoliu, Z. Siudak, T. Damy, H. Dores, G. Tsaoussis, Gert Baumann, J. Jakala, Z. Kalarus, R. Jasaityte, G. Dan, K. Takenaka, M. Gurzun, M. Mavroidis, R. Florez Gomez, S. Winter, A. Ebihara, E. Fousteris, N. Catibog, B. Kilickiran Avci, A. Deligiorgis, R. Sharma, A. Alonso Ladreda, M. Dorobantu, Y. Lutay, P. Barbier, O. Jobard, J. Jedrzychowska-Baraniak, M. Perez-Lopez, Y. Yatomi, C. Itziar Soto, P. Polisca, K. Adamyan, B. Putnikovic, M. Lourenco, N. Taha, C. Ebner, K. Obase, P. Podolec, F. Romeo, M. Yamamoto, K. Shahgaldi, T. Edvardsen, C. Leon, A. Varela, A. Anastasakis, D. Oh, I. Di Matteo, A. Manouras, A. Theodosis-Georgilas, J. Bernstein, D. Cini, P. Reant, L. Santini, I. Quelhas, A. Bacaksiz, E. Agabiti Rosei, S. Bartosh-Zelenaya, R. Enache, C. Baicus, G. T. Tura, K. Kimura, R. Esposito, P. Kekovic, A. Whittaker, K. Park, N. Monteforte, S. Foussas, M. Kostkiewicz, S. Damjanovic, T. Ishizu, I. Ene, L. Chiariello, M. van Bracht, L. Segreti, T. Gaspar, A. Neves, M. Estensen, S. Carerj, H. Nesser, K. Yoshida, E. Prappa, S. Connolly, A. Djordjevic-Dikic, A. Calin, P. Carrilho-Ferreira, V. Di Bello, C. Beladan, S. Im, Sebastian Spethmann, S. Hakky, U. Trecroci, S. Tamai, L. Wrotniak, J. Necas, H. Marques, A. Neskovic, K. Skjetne, M. Galderisi, V. Ruddox, C. Adam, J. Leshko, H. Le Marec, A. Mateescu, L. Tunyan, F. Baeza, R. De Lucia, S. Aakhus, W. Serra, D. Simion, I. Stankovic, L. G. Garcia-Moreno, S. Sahin, P. Seferovic, M. Casartelli, E. Nobili, J. Marques, V. Davutoglu, O. Goktekin, C. Ginghina, D. Gemma, C. Yodwut, T. Sakakura, M. Nedeljkovic, S. Viani, H. Von Bibra, N. Protonotarios, R. Onut, H. Dalen, E. Romo, S. Woo, M. Franzosi, D. Zamfir, P. Ierano, J. S. De Lezo, E. Yeager, H.-J. Trappe, F. Pereira Machado, S. Grego, C. Gronlund, J. O'driscoll, C. Tsilafakis, L. Carpinteiro, L. Sironi, B. Diaz Molina, V. Probst, P. Sousa, N. Hammoudi, S. Kovalova, L. Paperini, M. Lunati, H. Seo, G. Ferrari, J. Roquette, F. Toledano, R. Jurkevicius, G. Nicolosi, D. Mohty, V. Giga, R. Sachner, T. Butz, F. Pousset, O. Sonmez, N. Reckefuss, O. Vriz, G. Dobson, J. Zdzienicka, V. Labate, F. Pinto, C. Jorge, F. Purcarea, T. Wutthachusin, R. Strasser, I. Kostavassili, M. Szulik, D. Danford, J. Vignalou, D. Popovic, M. Ruiz Ortiz, B. Popescu, O. Guseva, J. Rios Blanco, S. Purkayastha, D. Zaliaduonyte-Peksiene, J. Lopez Sendon, A. Magalhaes, G. Plehn, A. Tanrikulu, D. Mesa, G. Di Bella, D. Muraru, M. Salvetti, A. Arandjelovic, and M. Costantino

Subjects
medicine.medical_specialty, business.industry, Alternative medicine, Physical therapy, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2012

50. IVRT'/IVRT Index Is a Useful Tool for Detection of Elevated Left Ventricular Filling Pressure in Patients with Preserved Ejection Fraction

Author

Tadeusz Przewłocki, R. Rudko, Mieczysław Pasowicz, Barbara Biernacka, Wiesława Tracz, and and Anna Kablak-Ziembicka M.D.

Subjects
Male, medicine.medical_specialty, Diastole, Hemodynamics, Doppler imaging, Ventricular Dysfunction, Left, Internal medicine, Mitral valve, Ventricular Pressure, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Isovolumetric contraction, Aged, Heart Failure, Diastolic, Ejection fraction, business.industry, Stroke Volume, Middle Aged, medicine.disease, Echocardiography, Doppler, medicine.anatomical_structure, ROC Curve, Heart failure, Linear Models, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Ventricular filling
Abstract

Objective: Deterioration of active relaxation results in prolongation of isovolumteric relaxation time (IVRT), however, when left ventricular filling pressure elevates, mitral valve opens earlier and IVRT shortens. This shortening is not seen when IVRT is measured with tissue Doppler imaging (IVRT′). Then, IVRT′ prolongs with the deceleration of active relaxation independent of left ventricular filling pressure. We hypothesized that IVRT′ reflects the relaxation rate, thus, the ratio of IVRT′ to IVRT may possibly detect left ventricular filling pressure elevation. Methods: The group of 39 subjects (aged 64 ± 5 years) with preserved ejection fraction (EF > 50%) underwent combined echocardiographic and hemodynamic examinations. Echocardiographic parameters of mitral inflow and mitral annular motion were correlated with invasive indices of left ventricular relaxation and filling pressure. Results: Time constant of isovolumetric pressure decline (tau) correlated closely with IVRT′ (r = 0.73, P < 0.001) but not with early diastolic velocity of mitral annulus (E′) (r =−0.207, P = 0.206). The best parameter correlating with M-LVDP was IVRT′/IVRT (r = 0.694, P < 0.001, M-LVDP = 7.7 × IVRT′/IVRT + 5.1). A weaker relation was also noted between the ratio of early mitral peak inflow velocity to early diastolic velocity of mitral annulus (E/E′) and M-LVDP (r = 0.469, P < 0.001). The relationships between standard Doppler parameters and left ventricular diastolic pressures were uniformly poor. Conclusions: The study demonstrated that IVRT′ may serve as a surrogate of left ventricular active relaxation. IVRT′/IVRT index may be applied to estimate left ventricular filling pressure.

Published
2008

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