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4. Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease.

Author

Chandran, Rachana R., Adams, Taylor S., Kabir, Inamul, Gallardo-Vara, Eunate, Kaminski, Naftali, Gomperts, Brigitte N., and Greif, Daniel M.

Subjects
MYOFIBROBLASTS, LUNGS, GENE expression profiling, TISSUE remodeling, MUSCLE cells
Abstract

Alveolarization ensures sufficient lung surface area for gas exchange, and during bulk alveolarization in mice (postnatal day [P] 4.5-14.5), alpha-smooth muscle actin (SMA)+ myofibroblasts accumulate, secrete elastin, and lay down alveolar septum. Herein, we delineate the dynamics of the lineage of early postnatal SMA+ myofibroblasts during and after bulk alveolarization and in response to lung injury. SMA+ lung myofibroblasts first appear at ~ P2.5 and proliferate robustly. Lineage tracing shows that, at P14.5 and over the next few days, the vast majority of SMA+ myofibroblasts downregulate smooth muscle cell markers and undergo apoptosis. Of note, ~8% of these dedifferentiated cells and another ~1% of SMA+ myofibroblasts persist to adulthood. Single cell RNA sequencing analysis of the persistent SMA-cells and SMA+ myofibroblasts in the adult lung reveals distinct gene expression profiles. For instance, dedifferentiated SMA-cells exhibit higher levels of tissue remodeling genes. Most interestingly, these dedifferentiated early postnatal myofibroblasts re-express SMA upon exposure of the adult lung to hypoxia or the pro-fibrotic drug bleomycin. However, unlike during alveolarization, these cells that re-express SMA do not proliferate with hypoxia. In sum, dedifferentiated early postnatal myofibroblasts are a previously undescribed cell type in the adult lung and redifferentiate in response to injury. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Age of the bone marrow dictates clonality of smooth muscle-derived cells in the atherosclerotic plaque

Author

Kabir, Inamul, primary, Zhang, Xinbo, additional, Dave, Jui M., additional, Chakraborty, Raja, additional, Qu, Rihao, additional, Chandran, Rachana R., additional, Ntokou, Aglaia, additional, Gallardo-Vara, Eunate, additional, Aryal, Binod, additional, Rotllan, Noemi, additional, Garcia-Milian, Rolando, additional, Hwa, John, additional, Kluger, Yuval, additional, Martin, Kathleen A., additional, Fernández-Hernando, Carlos, additional, and Greif, Daniel M., additional

Published
2022
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11. 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity

Author

Lou, Bin, primary, Liu, Qi, additional, Hou, Jiahui, additional, Kabir, Inamul, additional, Liu, Peipei, additional, Ding, Tingbo, additional, Dong, Jibin, additional, Mo, Mingguang, additional, Ye, Deyong, additional, Chen, Yang, additional, Bui, Hai H., additional, Roth, Kenneth, additional, Cao, Yu, additional, and Jiang, Xian-Cheng, additional

Published
2018
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12. Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

Author

Misra, Ashish, primary, Feng, Zhonghui, additional, Chandran, Rachana R., additional, Kabir, Inamul, additional, Rotllan, Noemi, additional, Aryal, Binod, additional, Sheikh, Abdul Q., additional, Ding, Ling, additional, Qin, Lingfeng, additional, Fernández-Hernando, Carlos, additional, Tellides, George, additional, and Greif, Daniel M., additional

Published
2018
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13. Contributors

Author

Aboyans, Victor, Abraham, Cherrie Z., Aday, Aaron W., Alabi, Olamide, Alba, George A., Alberts, Mark J., Arnaoutakis, George J., Battinelli, Elisabeth M., Bavaria, Joseph E., Beckman, Joshua A., Belkin, Michael, Blei, Francine, Blume, Peter, Bonaca, Marc P., Brittain, Evan L., Carrier, Marc, Carroll, Brett J., Cavallo, Armando Ugo, Chan, Stephen Y., Chung, Jayer, Cid, Maria C., Colvard, Benjamin D., Cooper, Christopher J., Creager, Mark A., Criqui, Michael H., Cushman, Mary, Dake, Michael D., Darves-Bornoz, Annie L., Davis, Mark D.P., Dean, Steven M., Eberhardt, Robert T., Edwards, Matthew S., Eirin, Alfonso, Farber, Alik, Fisher, Marc, Flavahan, Nicholas A., Friedman, Kevin G., Gerhard-Herman, Marie, Gloviczki, Peter, Goldhaber, Samuel Z., Goldstein, Larry B., Gornik, Heather L., Greif, Daniel M., Griendling, Kathy K., Hamburg, Naomi M., Henkin, Stanislav, Hilenski, Lula L., Jayaraj, Arjun, Jayarajan, Senthil, Jones, Douglas W., Jung, Enjae, Kabir, Inamul, Keegan, Kirk A., Kermani, Tanaz A., Koopmann, Matthew C., Koster, Matthew J., Kramer, Christopher M., Landry, Gregory J., Leopold, Jane A., Lerman, Lilach O., Libby, Peter, Loscalzo, Joseph, Lotto, Christine E., Maegdefessel, Lars, Manwani, Bharti, Maron, Bradley A., Mena-Hurtado, Carlos, Menard, Matthew T., Merkel, Peter A., Monach, Paul A., Moneta, Gregory L., Newburger, Jane W., Ntokou, Aglaia, O’Gara, Patrick T., Olin, Jeffrey W., Penson, David F., Piazza, Gregory, Pollak, Amy West, Powell, Richard J., Raaz, Uwe, Rajagopalan, Sanjay, Rockson, Stanley G., Rooke, Thom W., Roy, Rishi A., Saddouk, Fatima Zahra, Sartori-Valinotti, Julio C., Shannon, Alexander H., Sharma, Aditya, Shepherd, Roger F.J., Sobieszczyk, Piotr, Spin, Joshua M., Stone, David H., Suckow, Bjoern D., Sumpio, Bauer E., Textor, Stephen C., Thomas, Rahul B., Thompson, Robert, Tsao, Philip S., Upchurch, Gilbert R., Jr., VanNostrand, Meg, Warrington, Kenneth J., Wasan, Suman, White, Christopher J., White Solaru, Khendi T., and Zacharias, Nikolaos

Published
2020
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14. Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis

Author

Li, Zhiqiang, primary, Kabir, Inamul, additional, Jiang, Hui, additional, Zhou, Hongwen, additional, Libien, Jenny, additional, Zeng, Jianying, additional, Stanek, Albert, additional, Ou, Peiqi, additional, Li, Kailyn R., additional, Zhang, Shane, additional, Bui, Hai H., additional, Kuo, Ming‐Shang, additional, Park, Tae‐Sik, additional, Kim, Benjamin, additional, Worgall, Tilla S., additional, Huan, Chongmin, additional, and Jiang, Xian‐Cheng, additional

Published
2016
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17. Identification of a novel dehydration responsive transcript from tossa jute (Corcohrus olitorius L.).

Author

SHARMIN, Sazi, MOOSA, Mahdi Muhammad, ISLAM, Shahidul, KABIR, Inamul, AKTER, Arzuba, and KHAN, Haseena

Subjects
*TOSSA jute, *ENVIRONMENTAL engineering, *DROUGHTS, *PLANT roots, *PLANT shoots, *LEAVES
Abstract

Water deficit stress is one of the major environmental stress conditions faced by sessile land plants. Acquisition of resistance to this stress enabled plants to settle into terrestrial habitats. Dehydration stress is a specific form of water deficit stress. A number of functionally characterized genes are involved in dehydration response pathway. Here we report a novel dehydration responsive transcript from tossa jute (Corcohrus olitorius L.) which shows reduced expression under dehydration stress. Study of tissue specific expression revealed that the transcript is expressed in root, shoot and leaf under normal conditions. Search for known homologues of the transcript failed to identify functionally characterized counterparts in any other plant species. [ABSTRACT FROM AUTHOR]

Published
2011

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