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Rotational malalignment following intramedullary nailing is a well-recognised problem. The threshold for clinically relevant malrotation has been established to be in the region of 15° whereas the incidence of significant malrotation following femoral nailing ranges from 22 to 43 percent. Many studies have been performed to address this issue with the major challenge acknowledged to be intraoperative control of femoral anteversion. In the current study, the investigators developed and analysed a novel method to estimate the femoral antetorsion based on computed tomography (CT) data. They hypothesized that this method would be intra-operatively feasible and repeatable without further radiation. CT scans (n=166) of femoral neck fractures performed between 2005 and 2010 were evaluated. Twenty patients had a femoral neck fracture and thus were excluded. Every femoral neck was measured according the method described by Jend et al. and the current authors. In contrast to the Jend method, the current authors described femoral antetorsion as the angle between the ventral cortex of the femoral neck and the posterior condylar line. To determine this angle, the axial cuts from computed tomography data were studied. In order to maximise measurement consistencty among cases, the axial cut which displayed the intertrochanteric crest was selected. Mean femoral antetorsion is 12.15°±10.04° according to Jend et al. In comparison, a mean angle of 12.61°±11.16° was demonstrated in the current study. The absolute difference in measuring the femoral neck angle when these different methods are compared was 4.44°. Statistically, there is no significant difference between the mean results for femoral antetorsion. The advantage of the method proposed in the current study, is the opportunity to enter the ventral femoral cortex during the surgical procedure without disturbing the process of femoral nailing. Thus, the surgeon can avail of continuous control of femoral rotation intra-operatively. [ABSTRACT FROM AUTHOR]

There are considerable differences between males and females regarding the etiology, progression and outcome of liver diseases. Infections are a frequent and severe complication in these patients. This study aimed to examine sex specific differences in the incidence and clinical course of nosocomial infections in patients with decompensated liver cirrhosis. A number of 556 consecutive hospitalized patients with decompensated liver cirrhosis and ascites were analyzed. The patients were followed up for the incidence of nosocomial infections, acute kidney injury (AKI), acute-on-chronic liver failure (ACLF) as well as liver transplantation and death (LTx-free survival). A number of 285 patients (111 women and 174 men) developed a nosocomial infection. Incidence was numerically lower in men (P = 0.076). While the frequency of a nosocomial spontaneous bacterial peritonitis was similar between males and females, the incidence of a nosocomial urinary tract infection was significantly higher in women (P < 0.001). No sex specific differences were documented regarding the outcome of an infection as indicated by a similar incidence of, AKI, ACLF as well as LTx-free survival. There seem to be no major differences in the incidence and outcome of nosocomial infections between male and female patients., (© 2022. The Author(s).)

Acute-on-chronic liver failure (ACLF) is a newly defined syndrome in patients with liver cirrhosis characterized by acute hepatic decompensation (jaundice, ascites, hepatic encephalopathy, bacterial infection and gastrointestinal bleeding), single or multiple organ failure and a high mortality (>15% within 28 days). The affected organ systems include not only the liver but also the circulation, lungs, kidneys, brain and/or coagulation. Pathophysiologically decisive is an uncontrolled inflammation that is induced by specific triggers and on the basis of previously (possibly not diagnosed) compensated as well as already decompensated liver cirrhosis leads to a severe systemic clinical syndrome, ACLF. The course during the first 72 h is decisive for the prognosis. In addition to treatment of the respective organ or system failure, the underlying triggers should be quickly identified and if necessary specifically treated. Often, however, these cannot (no longer) be determined with any certainty, in particular recent alcohol consumption as well as bacterial and viral infections play an important role. A specific treatment for the ACLF is (currently) not established. Some experimental approaches are currently being tested, including administration of granulocyte colony-stimulating factor (GCSF). Additionally, suitable patients should be presented to a liver transplantation center in a timely manner.

Background:  The economic effects of spontaneous bacterial peritonitis (SBP), nosocomial infections (nosInf) and acute-on-chronic liver failure (ACLF) have so far been poorly studied. We analyzed the impact of these complications on treatment revenues in hospitalized patients with decompensated cirrhosis., Methods:  371 consecutive patients with decompensated liver cirrhosis, who received a paracentesis between 2012 and 2016, were included retrospectively. DRG (diagnosis-related group), "ZE/NUB" (additional charges/new examination/treatment methods), medication costs, length of hospital stay as well as different kinds of specific treatments (e. g., dialysis) were considered. Exclusion criteria included any kind of malignancy, a history of organ transplantation and/or missing accounting data., Results:  Total treatment costs (DRG + ZE/NUB) were higher in those with nosInf (€ 10,653 vs. € 5,611, p < 0.0001) driven by a longer hospital stay (23 d vs. 12 d, p < 0.0001). Of note, revenues per day were not different (€ 473 vs. € 488, p = 0.98) despite a far more complicated treatment with a more frequent need for dialysis (p < 0.0001) and high-complex care (p = 0.0002). Similarly, SBP was associated with higher total revenues (€ 10,307 vs. € 6,659, p < 0.0001). However, the far higher effort for the care of SBP patients resulted in lower daily revenues compared to patients without SBP (€ 443 vs. € 499, p = 0.18). ACLF increased treatment revenues to € 10,593 vs. €6,369 without ACLF (p < 0.0001). While treatment of ACLF was more complicated, revenue per day was not different to no-ACLF patients (€ 483 vs. € 480, p = 0.29)., Conclusion:  SBP, nosInf and/or ACLF lead to a significant increase in the effort, revenue and duration in the treatment of patients with cirrhosis. The lower daily revenue, despite a much more complex therapy, might indicate that these complications are not yet sufficiently considered in the German DRG system., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (© Georg Thieme Verlag KG Stuttgart · New York.)

Background: Nosocomial infections are a particular threat for patients with liver cirrhosis. It is not uncommon that individuals develop even several consecutive infections during a single hospital stay. We aimed to investigate the impact and characteristics of multiple, consecutive nosocomial infections., Methods: A total of 514 consecutive patients with liver cirrhosis and ascites were included and followed up for 28 days for nosocomial infection, death or liver transplantation (LTx). Laboratory values were assessed at the time of hospitalization as well as at the onset of each new infectious episode., Results: 58% ( n  = 298) of the patients developed at least one nosocomial infection and in 23% ( n  = 119) even multiple infections were documented during a single hospital stay. Consecutive infections usually occurred shortly after the previous episode. Spontaneous bacterial peritonitis (SBP) was the most common infection. However, the proportion of SBP declined from 43% at the first to only 31% at the third nosocomial infection ( p  = 0.096). In contrast, the likelihood for other, less common types of infection such as blood stream infections increased. Third nosocomial infections were also more likely to be linked to the detection of fungal pathogens (21% vs. 52%; p  = 0.001). Each additional infectious episode had a dramatic detrimental impact on LTx-free survival that was independent from the stage of liver disease (adjusted-HR: 6.76, p  = 0.002 for first nosocomial infection; adjusted-HR: 14.69, p <0.001 for second nosocomial infection; adjusted-HR: 24.95, p <0.001 for third nosocomial infection)., Conclusion: In patients with decompensated liver cirrhosis LTx-free survival significantly decreases with every consecutive infectious episode. Development of prevention strategies is urgently required.

Purpose: Patients after radical cystectomy (RC) frequently complain about bowel disorders (BDs). Reports addressing related long-term complications are sparse. This cross-sectional study assessed changes in bowel habits (BH) after RC., Methods: A total of 89 patients with a minimum follow-up ≥1 year after surgery were evaluated with a questionnaire. Patients with BD prior to surgery were excluded. Symptoms such as diarrhea, constipation, bloating/flatulence, incomplete defecation, uncontrolled stool loss, and impact on quality of life (QoL) were assessed., Results: A total of 46.1 % of patients reported changes in BH; however, only 25.8 % reported experiencing related dissatisfaction. Primary causes of dissatisfaction were diarrhea and uncontrolled stool loss. The most common complaints were bloating/flatulence and the feeling of incomplete defecation, but these symptoms did not necessarily lead to dissatisfaction or impairment in quality of life. No difference was identified between an orthotopic neobladder and ileal conduit, and even patients without bowel surgery were affected. QoL, health status, and energy level were significantly decreased in unsatisfied patients., Conclusions: About 25 % of patients complain about BDs after RC. More prospective studies assessing symptoms, comorbidities, and dietary habits are necessary to address this issue and to identify strategies for follow-up recommendations.

Background: Malrotation after femoral nailing is a common problem, yet estimation of the correct rotation during nailing remains a technical challenge. In the current study, a novel technique was developed for determining femoral antetorsion, the anterior cortical angle (ACA) method. The ACA is the angle between a line along the anterior aspect of the femoral neck and the posterior condylar line of the distal femur. The principal advantage of this method is that it facilitates intra-operative assessment of femoral antetorsion by utilizing the positional technology integrated in smartphones. This measurement is directly comparable to measurements made using computed tomography (CT) scans. The objective of the current study was to investigate the possibility and to validate the feasibility and accuracy of the new method and compare the results obtained with the traditional methods of antetorsion estimation via CT and surgical navigation technology., Methods: Twelve cadaveric femora were used. Femoral antetorsion was measured with the ACA method, using a smartphone with integrated gyroscope (Apple IPhone, Cupertino, CA, USA) and by a conventional navigated technique (Brainlab, Feldkirchen, Germany). Subsequently, all femora underwent CT scanning to measure their respective antetorsion via the ACA and the method of Jend (1986). Next, a mid-diaphyseal osteotomy was performed and the distal fragment was rotated and were adjusted to 10-15° using ACA by smartphone. All measurements were repeated with this new position of the femoral fragments., Results: Both radiological measurements according ACA and Jend (1986) demonstrated a statistically significant correlation (intact femur, r = 0.773, p = 0.003; after fixation, r = 0.898, p < 0.001). Comparing the measurements derived from the ACA, as analysed on CT images, and that gleaned from the experimental use of the same method with the smartphone, a statistically significant correlation was also demonstrated (intact femur, r = 0.826, p = 0.001; after fixation, r = 0.932, p < 0.001). Comparing the navigation system and the ACA measured by smartphone there was, on intact femora, a fair correlation without statistical significance and after fixation a good correlation with statistical significance (intact femur, r = 0.467, p = 0.126; after fixation, r = 0.869, p = 0.001)., Conclusions: The ACA method generated acceptable results and could contribute to improving the results of femoral nailing. The use of this device in a real clinical setting is necessary to truly elucidate its utility., (Copyright © 2012 John Wiley & Sons, Ltd.)