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Your search keyword '"Kabbage, Mehdi"' showing total 173 results
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173 results on '"Kabbage, Mehdi"'

14. Plant-derived antifungal agent poacic acid targets β-1,3-glucan

Author

Piotrowski, Jeff S., Okada, Hiroki, Lu, Fachuang, Li, Sheena C., Hinchman, Li, Ranjan, Ashish, Smith, Damon L., Higbee, Alan J., Ulbrich, Arne, Coon, Joshua J., Deshpande, Raamesh, Bukhman, Yury V., McIlwain, Sean, Ong, Irene M., Myers, Chad L., Boone, Charles, Landick, Robert, Ralph, John, Kabbage, Mehdi, and Ohya, Yoshikazu

Published
2015

15. Fungicide sensitivity of Sclerotinia sclerotiorum from U.S. soybean and dry bean, compared to different regions and climates

Author

Nieto-López, Edgar Humberto, primary, Miorini, Thomas J. J., additional, Wulkop-Gil, Cristian A., additional, Chilvers, Martin I., additional, Giesler, Loren, additional, Jackson-Ziems, Tamra A., additional, Kabbage, Mehdi, additional, Mueller, Daren S., additional, Smith, Damon L., additional, Tovar-Pedraza, Juan Manuel, additional, Willbur, Jaime F., additional, and Everhart, Sydney, additional

Published
2023
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23. A broadly conserved fungal alcohol oxidase (AOX) facilitates fungal invasion of plants.

Author

Westrick, Nathaniel M., Park, Sung Chul, Keller, Nancy P., Smith, Damon L., and Kabbage, Mehdi

Subjects
SCLEROTINIA sclerotiorum, PLANT invasions, PLANT colonization, ALCOHOL, PLANT-fungus relationships, PLANT extracts, SOYBEAN diseases & pests
Abstract

Alcohol oxidases (AOXs) are ecologically important enzymes that facilitate a number of plant–fungal interactions. Within Ascomycota they are primarily associated with methylotrophy, as a peroxisomal AOX catalysing the conversion of methanol to formaldehyde in methylotrophic yeast. In this study we demonstrate that AOX orthologues are phylogenetically conserved proteins that are common in the genomes of nonmethylotrophic, plant‐associating fungi. Additionally, AOX orthologues are highly expressed during infection in a range of diverse pathosystems. To study the role of AOX in plant colonization, AOX knockout mutants were generated in the broad host range pathogen Sclerotinia sclerotiorum. Disease assays in soybean showed that these mutants had a significant virulence defect as evidenced by markedly reduced stem lesions and mortality rates. Chemical genomics suggested that SsAOX may function as an aromatic AOX, and growth assays demonstrated that ΔSsAOX is incapable of properly utilizing plant extract as a nutrient source. Profiling of known aromatic alcohols pointed towards the monolignol coniferyl alcohol (CA) as a possible substrate for SsAOX. As CA and other monolignols are ubiquitous among land plants, the presence of highly conserved AOX orthologues throughout Ascomycota implies that this is a broadly conserved protein used by ascomycete fungi during plant colonization. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses

Author

O'Connell, Richard J, Thon, Michael R, Hacquard, Stéphane, Amyotte, Stefan G, Kleemann, Jochen, Torres, Maria F, Damm, Ulrike, Buiate, Ester A, Epstein, Lynn, Alkan, Noam, Altmüller, Janine, Alvarado-Balderrama, Lucia, Bauser, Christopher A, Becker, Christian, Birren, Bruce W, Chen, Zehua, Choi, Jaeyoung, Crouch, Jo Anne, Duvick, Jonathan P, Farman, Mark A, Gan, Pamela, Heiman, David, Henrissat, Bernard, Howard, Richard J, Kabbage, Mehdi, Koch, Christian, Kracher, Barbara, Kubo, Yasuyuki, Law, Audrey D, Lebrun, Marc-Henri, Lee, Yong-Hwan, Miyara, Itay, Moore, Neil, Neumann, Ulla, Nordström, Karl, Panaccione, Daniel G, Panstruga, Ralph, Place, Michael, Proctor, Robert H, Prusky, Dov, Rech, Gabriel, Reinhardt, Richard, Rollins, Jeffrey A, Rounsley, Steve, Schardl, Christopher L, Schwartz, David C, Shenoy, Narmada, Shirasu, Ken, Sikhakolli, Usha R, Stüber, Kurt, Sukno, Serenella A, Sweigard, James A, Takano, Yoshitaka, Takahara, Hiroyuki, Trail, Frances, van der Does, H Charlotte, Voll, Lars M, Will, Isa, Young, Sarah, Zeng, Qiandong, Zhang, Jingze, Zhou, Shiguo, Dickman, Martin B, Schulze-Lefert, Paul, Ver Loren van Themaat, Emiel, Ma, Li-Jun, and Vaillancourt, Lisa J

Published
2012
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27. Host-Induced Gene Silencing of a Sclerotinia sclerotiorum oxaloacetate acetylhydrolase Using Bean Pod Mottle Virus as a Vehicle Reduces Disease on Soybean

Author

McCaghey, Megan, primary, Shao, Dandan, additional, Kurcezewski, Jake, additional, Lindstrom, Ally, additional, Ranjan, Ashish, additional, Whitham, Steven A., additional, Conley, Shawn P., additional, Williams, Brett, additional, Smith, Damon L., additional, and Kabbage, Mehdi, additional

Published
2021
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29. Host-Induced Gene Silencing of a Sclerotinia sclerotiorum oxaloacetate acetylhydrolase Using Bean Pod Mottle Virus as a Vehicle Reduces Disease on Soybean

Author

McCaghey, Megan, Shao, Dandan, Kurcezewski, Jake, Lindstrom, Ally, Ranjan, Ashish, Whitham, Steven, Conley, Shawn, Williams, Brett, Smith, Damon, Kabbage, Mehdi, McCaghey, Megan, Shao, Dandan, Kurcezewski, Jake, Lindstrom, Ally, Ranjan, Ashish, Whitham, Steven, Conley, Shawn, Williams, Brett, Smith, Damon, and Kabbage, Mehdi

Abstract

A lack of complete resistance in the current germplasm complicates the management of Sclerotinia stem rot (SSR) caused by Sclerotinia sclerotiorum in soybean. In this study, we used bean pod mottle virus (BPMV) as a vehicle to down-regulate expression of a key enzyme in the production of an important virulence factor in S. sclerotiorum, oxalic acid (OA). Specifically, we targeted a gene encoding oxaloacetate acetylhydrolase (Ssoah1), because Ssoah1 deletion mutants are OA deficient and non-pathogenic on soybean. We first established that S. sclerotiorum can uptake environmental RNAs by monitoring the translocation of Cy3-labeled double-stranded and small interfering RNA (ds/siRNAs) into fungal hyphae using fluorescent confocal microscopy. This translocation led to a significant decrease in Ssoah1 transcript levels in vitro. Inoculation of soybean plants with BPMV vectors targeting Ssoah1 (pBPMV-OA) also led to decreased expression of Ssoah1. Importantly, pBPMV-OA inoculated plants showed enhanced resistance to S. sclerotiorum compared to empty-vector control plants. Our combined results provide evidence supporting the use of HIGS and exogenous applications of ds/siRNAs targeting virulence factors such as OA as viable strategies for the control of SSR in soybean and as discovery tools that can be used to identify previously unknown virulence factors.

Published
2021

30. Potential Biotechnological Applications of Autophagy for Agriculture

Author

Thanthrige, Nipuni, Bhowmik, Sudipta Das, Ferguson, Brett J., Kabbage, Mehdi, Mundree, Sagadevan G., Williams, Brett, Thanthrige, Nipuni, Bhowmik, Sudipta Das, Ferguson, Brett J., Kabbage, Mehdi, Mundree, Sagadevan G., and Williams, Brett

Abstract

Autophagy is a genetically regulated, eukaryotic cellular degradation system that sequestrates cytoplasmic materials in specialised vesicles, termed autophagosomes, for delivery and breakdown in the lysosome or vacuole. In plants, autophagy plays essential roles in development (e.g., senescence) and responses to abiotic (e.g., nutrient starvation, drought and oxidative stress) and biotic stresses (e.g., hypersensitive response). Initially, autophagy was considered a non-selective bulk degradation mechanism that provides energy and building blocks for homeostatic balance during stress. Recent studies, however, reveal that autophagy may be more subtle and selectively target ubiquitylated protein aggregates, protein complexes and even organelles for degradation to regulate vital cellular processes even during favourable conditions. The selective nature of autophagy lends itself to potential manipulation and exploitation as part of designer protein turnover machinery for the development of stress-tolerant and disease-resistant crops, crops with increased yield potential and agricultural efficiency and reduced post-harvest losses. Here, we discuss our current understanding of autophagy and speculate its potential manipulation for improved agricultural performance.

Published
2021

34. Centrality of BAGs in Plant PCD, Stress Responses, and Host Defense

Author

Peththa Thanthrige, Nipuni, Jain, Sachin, Das Bhowmik, Sudipta, Ferguson, Brett J., Kabbage, Mehdi, Mundree, Sagadevan, Williams, Brett, Peththa Thanthrige, Nipuni, Jain, Sachin, Das Bhowmik, Sudipta, Ferguson, Brett J., Kabbage, Mehdi, Mundree, Sagadevan, and Williams, Brett

Abstract

Programmed cell death (PCD) is a genetically regulated process for the selective demise of unwanted and damaged cells. Although our understanding of plant PCD pathways has advanced significantly, doubts remain on the extent of conservation of animal apoptosis in plants. At least at the primary sequence level, plants do not encode the regulators of animal apoptosis. Structural analyses have enabled the identification of the B cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family of co-chaperones in plants. This discovery suggests that some aspects of animal PCD are conserved in plants, while the varied subcellular localization of plant BAGs indicates that they may have evolved distinct functions. Here we review plant BAG proteins, with an emphasis on their roles in the regulation of plant PCD.

Published
2020

35. Additional file 4: of Gene regulation of Sclerotinia sclerotiorum during infection of Glycine max: on the road to pathogenesis

Author

Westrick, Nathaniel, Ranjan, Ashish, Jain, Sachin, Grau, Craig, Smith, Damon, and Kabbage, Mehdi

Abstract

Figure S1. Graph detailing select categories of genes that were upregulated either EARLY (Orange) or LATE (Blue). Genes were categorized using based on Blast2GO annotation or characterized homologues. (PDF 21 kb)

Published
2019
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38. Meta-Analytic and Economic Approaches for Evaluation of Pesticide Impact on Sclerotinia Stem Rot Control and Soybean Yield in the North Central United States

Author

Willbur, Jaime F., primary, Mitchell, Paul D., additional, Fall, Mamadou L., additional, Byrne, Adam M., additional, Chapman, Scott A., additional, Floyd, Crystal M., additional, Bradley, Carl A., additional, Ames, K. A., additional, Chilvers, Martin I., additional, Kleczewski, Nathan M., additional, Malvick, Dean K., additional, Mueller, Brian D., additional, Mueller, Daren S., additional, Kabbage, Mehdi, additional, Conley, Shawn P., additional, and Smith, Damon L., additional

Published
2019
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39. Resistance against Sclerotinia sclerotiorum in soybean involves a reprogramming of the phenylpropanoid pathway and up‐regulation of antifungal activity targeting ergosterol biosynthesis

Author

Ranjan, Ashish, primary, Westrick, Nathaniel M., additional, Jain, Sachin, additional, Piotrowski, Jeff S., additional, Ranjan, Manish, additional, Kessens, Ryan, additional, Stiegman, Logan, additional, Grau, Craig R., additional, Conley, Shawn P., additional, Smith, Damon L., additional, and Kabbage, Mehdi, additional

Published
2019
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41. Identification of a tractable model system and oxalic acid‐dependent symptom development of the dollar spot pathogen Clarireedia jacksonii.

Author

Rioux, Renée A., Stephens, Cameron M., Koch, Paul L., Kabbage, Mehdi, and Kerns, James P.

Subjects
BRACHYPODIUM, OXALIC acid, TURFGRASSES, PLANT identification, SYMPTOMS, MONOCOTYLEDONS, AGROSTIS
Abstract

Clarireediajacksonii causes dollar spot disease of cool‐season turfgrasses in the United States and produces the phytotoxin oxalic acid. The role of oxalic acid in host–pathogen interactions of C. jacksonii is unknown and there are multiple challenges to studying these interactions in natural turfgrass hosts. Consequently, identification of model plants to study C. jacksonii–host interactions and the role of oxalic acid in pathogenesis is necessary. Controlled environment inoculation assays were used to evaluate pathogenesis of C. jacksonii in various model plants and investigate the role of oxalic acid in symptom development. Observations at microscopic and macroscopic levels demonstrated that infection progressed similarly in all monocots tested (creeping bentgrass, wheat, barley, rice, Brachypodiumdistachyon) but not in the dicot Arabidopsisthaliana. Plant oxalic acid content increased from near zero to around 0.2–0.4 mM following inoculation with C. jacksonii in creeping bentgrass, barley, and wheat. Conversely, oxalic acid content remained near zero in A. thaliana and was not well correlated with inoculation in rice and B. distachyon, both of which had higher endogenous oxalic acid levels than other monocots. Time‐course oxalic acid quantification experiments with creeping bentgrass and B. distachyon further supported a link between symptom development and in planta oxalic acid content and identified 48 hr postinoculation as a critical time‐point for investigating the role of oxalic acid in C. jacksonii pathogenesis. These studies demonstrate that various monocots can serve as tractable model systems for studying C. jacksonii–host interactions and that increases in oxalic acid content are associated with C. jacksonii symptom development. [ABSTRACT FROM AUTHOR]

Published
2021
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42. The pathogenic development of Sclerotinia sclerotiorum in soybean requires specific host NADPH oxidases

Author

Ranjan, Ashish, Jayaraman, Dhileepkumar, Grau, Craig, Hill, John H., Whitham, Steven A., Ané, Jean‐Michel, Smith, Damon L., and Kabbage, Mehdi

Subjects
Ascomycota, food and beverages, NADPH Oxidases, Original Articles, Soybeans, Reactive Oxygen Species, Droughts, Plant Proteins
Abstract

The plant membrane-localized NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), play crucial roles in various cellular activities, including plant disease responses, and are a major source of reactive oxygen species (ROS). Sclerotinia sclerotiorum is a cosmopolitan fungal pathogen that causes Sclerotinia stem rot (SSR) in soybean. Via a key virulence factor, oxalic acid, it induces programmed cell death (PCD) in the host plant, a process that is reliant on ROS generation. In this study, using protein sequence similarity searches, we identified 17 soybean RBOHs (GmRBOHs) and studied their contribution to SSR disease development, drought tolerance and nodulation. We clustered the soybean RBOH genes into six groups of orthologues based on phylogenetic analysis with their Arabidopsis counterparts. Transcript analysis of all 17 GmRBOHs revealed that, of the six identified groups, group VI (GmRBOH-VI) was specifically and drastically induced following S. sclerotiorum challenge. Virus-induced gene silencing (VIGS) of GmRBOH-VI using Bean pod mottle virus (BPMV) resulted in enhanced resistance to S. sclerotiorum and markedly reduced ROS levels during disease development. Coincidently, GmRBOH-VI-silenced plants were also found to be drought tolerant, but showed a reduced capacity to form nodules. Our results indicate that the pathogenic development of S. sclerotiorum in soybean requires the active participation of specific host RBOHs, to induce ROS and cell death, thus leading to the establishment of disease.

Published
2017

43. Validating Sclerotinia sclerotiorum Apothecial Models to Predict Sclerotinia Stem Rot in Soybean (Glycine max) Fields

Author

Willbur, Jaime F., primary, Fall, Mamadou L., additional, Byrne, Adam M., additional, Chapman, Scott A., additional, McCaghey, Megan M., additional, Mueller, Brian D., additional, Schmidt, Roger, additional, Chilvers, Martin I., additional, Mueller, Daren S., additional, Kabbage, Mehdi, additional, Giesler, Loren J., additional, Conley, Shawn P., additional, and Smith, Damon L., additional

Published
2018
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47. Integrated soybean transcriptomics, metabolomics, and chemical genomics reveal the importance of the phenylpropanoid pathway and antifungal activity in resistance to the broad host range pathogenSclerotinia sclerotiorum

Author

Ranjan, Ashish, primary, Westrick, Nathaniel M., additional, Jain, Sachin, additional, Piotrowski, Jeff S., additional, Ranjan, Manish, additional, Kessens, Ryan, additional, Stiegman, Logan, additional, Grau, Craig R., additional, Smith, Damon L., additional, and Kabbage, Mehdi, additional

Published
2018
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49. Weather-Based Models for Assessing the Risk of Sclerotinia sclerotiorum Apothecial Presence in Soybean (Glycine max) Fields

Author

Willbur, Jaime F., primary, Fall, Mamadou L., additional, Bloomingdale, Christopher, additional, Byrne, Adam M., additional, Chapman, Scott A., additional, Isard, Scott A., additional, Magarey, Roger D., additional, McCaghey, Megan M., additional, Mueller, Brian D., additional, Russo, Joseph M., additional, Schlegel, Jay, additional, Chilvers, Martin I., additional, Mueller, Daren S., additional, Kabbage, Mehdi, additional, and Smith, Damon L., additional

Published
2018
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