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10 results on '"Kaasinen, S."'

1. Typical pitfalls leading to gaps between envisaged and realised impacts of manure and nutrient related projects - a gap analysis

Author

Lyngsø Foged, Henning, Szymanski, A, Sindhöj, Erik, Kuka, K, Krystoforski, M, Sarvi, M, Kaasinen, S, and Melnalksne, Z

Subjects
Environmental Sciences related to Agriculture and Land-use, Miljö- och naturvårdsvetenskap
Abstract

SuMaNu is a thematic platform concerning nutrients and manure management, established “in order to strengthen the impact of projects’ outcomes in the selected thematic field”, especially via better integration of project results and conclusions into policies. The present gap analysis clarifies in this connection gaps between envisaged and realised impacts of seven projects to promote sustainable manure management, and specifies the impeding pitfalls, i.e. shortcomings and weaknesses that have caused the missing impact. The rationale behind the gap analysis is to help the design and implementation of future projects to achieve stronger impact. For this aim, it summarizes knowledge of selected projects' ability to produce results and recommendations and to communicate these to the end users for integration into policies. To conduct the gap analysis, an approach of deductive and theory-testing research was used based on a set of described and classified potential pitfalls in project design and implementation that could potentially lead to gaps between envisaged and realised policy impact of projects. Links between pitfall categories and implementation gaps were tested by the use of empirical data collected during this study. Six typical pitfalls were defined, and ten recommendations selected for the gap analysis. The analysis was as far as possible based on referenced documentation. Key target stakeholders representing Germany, Poland and Denmark as well as the BSR region were interviewed in order to increase the quality of the analysis and secure impartiality of the results. Generally, there were found gaps between envisaged and realised policy impacts. Out of the six classified pitfalls, not all projects had planned to create policy recommendations or impact among end users. The observed projects performed best with respect to producing planned results, whereas the most common pitfall was the ability to communicate these results. There were found considerable differences between the seven projects’ ability to support policy development and create impacts among end-users. It was among others concluded that projects are more likely to be integrated into policies and be implemented by end users if they adhere to some basic principles: 1) Objectives are SMART and in line with end-user needs; 2) Activities match the objectives and lead to the production of the foreseen results; and 3) Representatives of the administration and the end-users are directly involved in project partnerships and activities.

Published
2020

3. Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program

Author

Odin, P., Ray, Chaudhuri, Slevin, K., Volkmann, J. T., Dietrichs, J., Martinez Martin, E., Krauss, P., Henriksen, J. K., Katzenschlager, T., Antonini, Angelo, Rascol, A., Poewe, O., Brücke, W., Pirker, T., Ransmayr, W., Schwingenschuh, G., Tomantschger, P., Volc, V., Jespersen, D., Kamal, H., Karlsborg, A., Oppel, M., Pedersen, L., Avikainen, S., Kaasinen, S., Pekkonen, V., Ruottinen, E., Azulay, H., Corvol, J. P., Courbon, J. C., Defebvre, C. B., Durif, L., Houeto, F., Krack, J. L., Tison, P., Andrich, F., Ehret, J., Klostermann, R., Krüger, F., Lingor, R., Liszka, P., Schwarz, R., Timmermann, J., Warnecke, L., Bostantjopoulou, T., Konitsiotis, S., Papageorgiou, S., Stathishens, S., Stefanis, P., Zikos, L., Browne, P., Healy, P., Lynch, D., O'Riordan, T., O'Sullivan, S., Walsh, S., Abbruzzese, R., Lopiano, G., Modugno, L., Tamma, N., Holmberg, F., Linder, B., Nyholm, J., Pålhagen, D., Matías Arbelo, S., Bana, J., Castrillo, R. Y., Castro, J. C. M., e. Garcia Ruiz Espiga, A., Kulisevsky, P. J., Lezcano, J., Luquin, E., Mir, R., Puente, P., Valldeoriola, V., Burn, F., Clarke, D., Foltynie, C., Grosset, T., Hindle, D., Leake, J., Lees, A., Morris, A., Stewart, H., Walker, D., Worth, R., AbbVie, and Karlsborg, Merete

Subjects
medicine.medical_specialty, Parkinson's disease, Neurology, Consensus, Disease duration, Clinical Neurology, Non-motor symptoms, Disease, Surveys and Questionnaires, medicine, Humans, Device-aided therapies, Dyskinesias, Motor fluctuations, Orthopedic Equipment, Parkinson Disease, Medicine (all), Geriatrics and Gerontology, Neurology (clinical), Psychiatry, Cognitive impairment, Depression (differential diagnoses), business.industry, International survey, medicine.disease, Family medicine, business, Educational program
Abstract

Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aided management of PD. Fifty-six experts responded to a web-based survey, rating 15 questions as 'critically important;' these were refined to 10 questions by the ISC to be addressed through available evidence and expert opinion. Draft guidance was presented at international/national meetings and revised based on feedback. Key take-home points are: • Patients requiring levodopa >5 times daily who have severe, troublesome 'off' periods (>1-2 h/day) despite optimal oral/transdermal levodopa or non-levodopa-based therapies should be referred for specialist assessment even if disease duration is 70 years who have mild or moderate cognitive impairment, severe depression or other contraindications to DBS. Medical writing support was provided by Emma East and Lindy van den Berghe at Lucid Group and funded by AbbVie. Sí

Published
2015

6. Cells of the neuronal lineage play a major role in the generation of amyloid precursor fragments in gelsolin-related amyloidosis.

Author

Paunio, T, Kangas, H, Heinonen, O, Buc-Caron, M H, Robert, J J, Kaasinen, S, Julkunen, I, Mallet, J, and Peltonen, L

Abstract

Gelsolin-related amyloidosis or familial amyloidosis, Finnish type (FAF) (OMIM No105120) is a hereditary amyloid disease caused by a mutation in a precursor protein for amyloid (gelsolin) and characterized by corneal dystrophy and polyneuropathy. In vitro expression of the FAF-mutant (Asp187 --> Asn/Tyr) secretory gelsolin in COS cells leads to generation of an aberrant polypeptide presumably representing the precursor for tissue amyloid. Here, we provide evidence that this abnormal processing results from defective initial folding of the secreted FAF gelsolin due to the lack of the Cys188-Cys201 disulfide bond, normally formed next to the FAF mutation site. We compared cells of different tissue origin and discovered a dramatic difference between the amount of cleavage of FAF gelsolin to the amyloid precursor in neuronal and non-neuronal cells. More than half of the mutant gelsolin was cleaved in PC12 and in vitro differentiated human neuronal progenitor cells. In contrast, human fibroblasts and Schwannoma cell cultures showed only a limited capacity to cleave FAF gelsolin, although the cleavage mechanism per se seems to be similar in the various cell types. The present findings of processing and distribution of secreted FAF gelsolin in the neuronal cells emphasize the role of neurons in the tissue pathogenesis of this amyloid polyneuropathy.

Published
1998

7. Intratympanic gentamicin in Meniere's disease.

Author

Kaasinen S, Pyykkö I, Ishizaki H, and Aalto H

Subjects
Adult, Aged, Anti-Bacterial Agents administration & dosage, Audiometry, Pure-Tone, Chi-Square Distribution, Electronystagmography, Exercise Therapy, Female, Gentamicins administration & dosage, Humans, Logistic Models, Male, Meniere Disease physiopathology, Middle Aged, Odds Ratio, Posture, Prospective Studies, Severity of Illness Index, Tympanic Membrane, Vertigo drug therapy, Anti-Bacterial Agents therapeutic use, Gentamicins therapeutic use, Meniere Disease drug therapy
Abstract

Ninety-three patients with intractable Meniere's disease were treated with gentamicin (Garamycin 40 mg/ml) administered in 1 to 4 transtympanic injections. The patients were tested at frequent intervals and followed up for 2 years. Before treatment all subjects experienced moderate or severe handicap caused by Meniere's disease. Two years after the treatment, rotatory vertigo was abolished in 81% of subjects, Tumarkin attacks were cured in 60%, and work capacity was severely reduced in 10% and moderately reduced in 17% of subjects. The outcome of the caloric responses did not correlate with the outcome of the treatment. In logistic regression analysis poor outcome of treatment correlated with Tumarkin attacks (odds ratio 5.5), severity of vertigo (odds ratio 3.8) and gait disorders (odds ratio 2.9). The mean hearing level was significantly affected by the treatment (before, 59.1 dB HL; after, 67.9 dB HL). Ten treated ears became deafened. During follow-up 44 subjects were subjected to retreatment, usually after 6 months. Intratympanic gentamicin treatment is a relatively safe and effective way to treat Meniere's disease. The authors recommended starting with 2 injections and renewing the injections if relapse occurs.

Published
1998
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8. Culturing of acoustic neuroma--methodological aspects.

Author

Kaasinen S, Pyykkö I, Koskiniemi ML, and Vaheri A

Subjects
Culture Media, Humans, Schwann Cells pathology, Tissue Survival physiology, Culture Techniques methods, Growth Substances physiology, Neuroma, Acoustic pathology
Abstract

We have been able to culture acoustic neuroma (AN) tissues by taking small tumor pieces during surgery from the cisternal or, preferably, metal part of the tumor where macroscopic tissue degeneration is not prominent. The AN pieces were transported in culture tubes to our cell laboratory where they were sliced and transferred to culture medium. The AN tissue demands a crude culture suspension containing laminin. We have been successful in culturing 15 successive ANs. The cells have different morphological features with characteristics of type Anthony A and B. Four main cell types were recognized: ameboid microglia-like cells, spindle-shaped cells, racket-shaped cells, and kite-shaped cells. However, no immortal cell line could be established. Some of the cultures were viable for up to 4 months.

Published
1995

9. Effect of intratympanically administered gentamicin on hearing and tinnitus in Menière's disease.

Author

Kaasinen S, Pyykkö I, Ishizaki H, and Aalto H

Subjects
Administration, Topical, Adult, Aged, Anti-Bacterial Agents adverse effects, Audiometry, Pure-Tone, Ear, Middle drug effects, Female, Gentamicins adverse effects, Humans, Male, Middle Aged, Pitch Discrimination drug effects, Speech Perception drug effects, Anti-Bacterial Agents administration & dosage, Auditory Threshold drug effects, Gentamicins administration & dosage, Meniere Disease drug therapy, Tinnitus drug therapy
Abstract

We have examined the effect of intratympanic gentamicin on hearing and tinnitus in 69 patients with intractable Menière's disease. Tinnitus was scored from 1 to 4 depending on its severity. The mean pure tone audiometry level before treatment was 57.5 dB and 1 year after treatment 63.5 dB Five subjects became deaf in the treated ear, and in 13 subjects hearing loss was > 10 dB and in 21 subjects 0 10 dB. In 25 subjects significant improvement (> 10 dB) was gained, and in 5 patients. Tinnitus was significantly reduced after treatment with gentamicin. A total of 66 patients had tinnitus before treatment and tinnitus relief was rated as good. Four percent of the subjects had no tinnitus, 30% had slight tinnitus. 27% moderate tinnitus. 18% severe and 8% handicapping tinnitus.

Published
1995
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10. Intratympanic gentamicin in bilateral Menière's disease.

Author

Pyykkö I, Ishizaki H, Kaasinen S, and Aalto H

Subjects
Adolescent, Adult, Caloric Tests, Child, Ear, Inner drug effects, Ear, Inner physiopathology, Electronystagmography, Female, Functional Laterality, Gentamicins administration & dosage, Gentamicins pharmacology, Hearing drug effects, Humans, Male, Meniere Disease diagnosis, Meniere Disease physiopathology, Posture, Severity of Illness Index, Tympanic Membrane physiopathology, Gentamicins therapeutic use, Meniere Disease drug therapy, Tympanic Membrane drug effects
Abstract

Treatment of bilateral Menière's disease is a delicate task. Streptomycin has demonstrated its ability to successfully control the vertigo attacks, but in some cases it results in oscillopsia and transforms the periodic attacks to permanent instability. If the site of the active labyrinth can be determined, a more specific treatment can be tried. We have treated 14 patients with intractable bilateral Menière's disease with intratympanic gentamicin (Garamycin, 40 mg/ml) administered initially in either 1, 2, 3, or 4 injections. The patients were tested at frequent intervals and followed up for 2 years. The work capacity, severity of vertigo, and gait difficulties were scored before treatment and during each test occasion. The postural stability was evaluated on a force platform and sway velocity was analyzed. Before treatment, moderate or severe reduction of work capacity was experienced by all of the subjects, which correlated to severity of vertigo and gait problems. Two years after treatment, the vertigo attacks were eliminated in 11 subjects and controlled in three subjects. The work capacity of three subjects was still moderately or severely reduced. This reduction depended on gait disturbance and Tumarkin attacks. The average postural stability returned to pretreatment level 2 years after the treatment was begun. The outcome of the caloric responses did not correlate with the outcome of the treatment. Hearing was not significantly affected by the treatment. Intratympanic gentamicin treatment is a relatively safe and effective way to treat bilateral Meniere's disease when the symptoms can be localized to one ear.

Published
1994
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