30 results on '"Käck, Helena"'
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2. The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity
3. Snapshot of a Phosphorylated Substrate Intermediate by Kinetic Crystallography
4. Combining structural and coevolution information to unveil allosteric sites
5. A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction
6. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
7. Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors
8. Protein Structure Dynamic Prediction: a Machine Learning/Molecular Dynamic Approach to Investigate the Protein Conformational Sampling
9. Fragment-Based Discovery of Novel Allosteric MEK1 Binders
10. A Homogeneous in Vitro Functional Assay for Estrogen Receptors: Coactivator Recruitment
11. Front Cover: An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors (ChemMedChem 19/2019)
12. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma
13. An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors
14. DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines
15. X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
16. Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)
17. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma
18. Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
19. Successful generation of structural information for fragment-based drug discovery
20. Yrkesrollens betydelse för etableringen på arbetsmarknaden
21. A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma
22. Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty
23. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
24. The manifold of vitamin B6 dependent enzymes
25. Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5′-phosphate-dependent enzymes
26. Structure of dethiobiotin synthetase at 0.97 Å resolution
27. Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis
28. Purification and preliminary X-ray crystallographic studies of recombinant 7,8-diaminopelargonic acid synthase from Escherichia coli
29. Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis.
30. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1 S ,2 S )-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
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