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14 results on '"KUMPULA, DAVID"'

2. Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers.

Author

Ngoi, Natalie Y L, Tang, Tin-Yun, Gaspar, Catia F, Pavlick, Dean C, Buchold, Gregory M, Scholefield, Emma L, Parimi, Vamsi, Huang, Richard S P, Janovitz, Tyler, Danziger, Natalie, Levy, Mia A, Pant, Shubham, Armas, Anaemy Danner De, Kumpula, David, Ross, Jeffrey S, Javle, Milind, and Ahnert, Jordi Rodon

Subjects
GASTROINTESTINAL tumors, GENOMICS, ADENOSINES, ANTINEOPLASTIC agents, TUMOR markers, CANCER patients, MEDICAL genetics, DISEASE prevalence, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, GENE expression, LONGITUDINAL method, MEDICAL records, ACQUISITION of data, TRANSFERASES, GENETIC mutation, COMPARATIVE studies, DRUG development, SEQUENCE analysis, PHARMACODYNAMICS
Abstract

Background One of the most common sporadic homozygous deletions in cancers is 9p21 loss, which includes the genes methylthioadenosine phosphorylase (MTAP), CDKN2A , and CDKN2B , and has been correlated with worsened outcomes and immunotherapy resistance. MTAP -loss is a developing drug target through synthetic lethality with MAT2A and PMRT5 inhibitors. The purpose of this study is to investigate the prevalence and genomic landscape of MTAP- loss in advanced gastrointestinal (GI) tumors and investigate its role as a prognostic biomarker. Materials and Methods We performed next-generation sequencing and comparative genomic and clinical analysis on an extensive cohort of 64 860 tumors comprising 5 GI cancers. We compared the clinical outcomes of patients with GI cancer harboring MTAP- loss and MTAP- intact tumors in a retrospective study. Results The prevalence of MTAP -loss in GI cancers is 8.30%. MTAP -loss was most prevalent in pancreatic ductal adenocarcinoma (PDAC) at 21.7% and least in colorectal carcinoma (CRC) at 1.1%. MTAP -loss tumors were more prevalent in East Asian patients with PDAC (4.4% vs 3.2%, P  = .005) or intrahepatic cholangiocarcinoma (IHCC; 6.4% vs 4.3%, P  = .036). Significant differences in the prevalence of potentially targetable genomic alterations (ATM , BRAF , BRCA2 , ERBB2 , IDH1 , PIK3CA , and PTEN) were observed in MTAP -loss tumors and varied according to tumor type. MTAP -loss PDAC, IHCC, and CRC had a lower prevalence of microsatellite instability or elevated tumor mutational burden. Positive PD-L1 tumor cell expression was less frequent among MTAP -loss versus MTAP -intact IHCC tumors (23.2% vs 31.2%, P  = .017). Conclusion In GI cancers, MTAP -loss occurs as part of 9p21 loss and has an overall prevalence of 8%. MTAP -loss occurs in 22% of PDAC, 15% of IHCC, 8.7% of gastroesophageal adenocarcinoma, 2.4% of hepatocellular carcinoma, and 1.1% of CRC and is not mutually exclusive with other targetable mutations. [ABSTRACT FROM AUTHOR]

Published
2024
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6. LETTERS TO THE EDITOR.

Author

ZEMLOCK, JOHN, LAW SR., ROY E., FRANK, PHYLLIS, MCCLURE, STAN, SHAW, MIKE, ROSSI, DAVID M., ENZENAUER, RAYMOND, and KUMPULA, DAVID

Subjects
VETERANS, AGENT Orange, OSTEOARTHRITIS
Published
2022

7. LETTERS TO THE EDITOR.

Author

CARD, BOB, AIRD, DON, HOWARD, LUCINDA, HOPSON, DAVE, DE GROFT, HERB, DENISON, RUSSELL, HOWARD, TRACI SLATTON, DEMALLIE, BOB, CONANT, RICK, KUMPULA, DAVID, PALKIE, RAYMOND J., DOMBROW, ROBERT, CASSIDY, SEAN P., CONN, TRISH, WEREB, LEW, MILLER, DON, OWEN, DAVE, BURNS, BILL, VAN BENNEKOM, BOB, and JORDAN, TOM

Subjects
WAX-modeling, GLOBAL Positioning System, MEDAL of Honor
Published
2021

8. LETTERS TO THE EDITOR.

Author

GREEN, MIKE, CHANDLER, JERRY, PAULING, MICHAEL, HINES, DEBBIE, CHEESER, GARY, VOTH, WILLIAM F., GRASSER, WILLIAM R., DAVINO, MIKE, AVERY, DAVE, HAYNES, BOB, STERNER, DOUG, WEBER, WILLIAM E., BENBOW, DAVID, PILLER, JERRY, HARRIS, CHARLES E., LACSINA, JOSEPH, KUMPULA, DAVID, BREWER, TED, CATES, ROGER, and SORRENTINO, PHIL

Subjects
KOREAN Demilitarized Zone (Korea)
Abstract

Several letters to the editor are presented in response to articles "Pearl Harbor: Three Survivors Recall the Japanese Attack" by Jerome Chandler in the November/December 2016 issue, "DMZ Firefight Ignites ‘Second Korean War" by Dave Newman; and "Second Korean War': Ground Combat, 1966-1969".

Published
2017

9. WHOSE MILITARY?

Author

Kopacz, Joseph C., Kumpula, David, Watkins, Richard, Peters, Harold W., Hassett, P. J., Beaudoin Jr., Rob, McGown Jr., Daniel, Watson, Dennis, Barker, Jerry, Ihnenfeld, Klaus-dieter, and Faircloth, Bob

Subjects
UNITED States. Air Force, TRUMP, Donald, 1946-, MANNING, Chelsea, 1987-
Abstract

Several letters to the editor are presented in response to articles in previous issues including “Trump's Air Force" and "14 hours of valor" in the November 28, 2016 issue, and “Attorney: Chelsea Manning again attempts suicide in prison" in the November 5, 2016 issue.

Published
2016

10. YOUR TAKE.

Author

Kopacz, Joseph C., Kumpula, David, Watkins, Richard, Peters, Harold W., Hassett, P. J., Beaudoin Jr., Rob, McGown Jr., Daniel, Watson, Dennis, Barker, Jerry, Ihnenfeld, Klaus-dieter, and Faircloth, Bob

Subjects
AIRMEN in the United States Air Force, BATTLE casualties
Abstract

Several letters to the editor are presented in response to articles in previous issues including "Attorney: Chelsea Manning again attempts suicide in prison" in the November 5, 2016 issue, "14 hours of valor" in the November 28, 2016 issue, and "25 years on, why it's time for a National Desert Storm Memorial," by Scott C. Stump in the December 12, 2016 issue.

Published
2016

11. WHAT YOU SAY.

Author

Keller, Jason, Heloise, Fiona, Castillo, Roger, Widener, Jim Fred, Fletcher, Donald, Davies, Linda, Emerson, Kendall, Luby, Kevin, Woodfin, Trent, Morgan, Thomas D., Ebert, Kim, Kumpula, David R., Neal, James R., Walton, Shane, Unger, Matthew, and Atwell, Scott

Subjects
WOMEN in combat
Abstract

Several letters to the editor are presented in response to articles of previous issues including "Congress offers praise, wariness on women in combat," one related to serving of women in combat in U.S. Air Force and "Uniform changes move ahead" in the November 2, 2015.

Published
2015

12. JOIN THE CONVERSATION.

Author

Nordstrom, Fred, Ricks, Johnny L., Gaffney, J. Thomas, Miyamoto, Don, Duguay, Daniel, Hazelbaker, Mark E., Kumpula, David, Holly, Tommy, Westerhof, Kristopher, Ascensio, Richard, Schouten, Bill, Williams, J. F., and Luna, Rudy

Subjects
MEDAL of Honor
Published
2017

13. YOUR TAKE.

Author

Kopacz, Joseph C., McHenry, Vincent, Vega-Ortiz, Jose D., Kumpula, David, Gentry, Rhett, and Logusz, Michael O.

Subjects
RECRUITING & enlistment (Armed Forces)
Published
2017

14. LETTERS.

Author

Eckert, Robert, Johnson, Wayne L., BarrettQ, Gary C., Kumpula, David, and Rollinson, John T.

Subjects
MORAL courage, SEX crimes, MILITARY officers, AMERICAN military personnel, PSYCHOLOGY
Abstract

Several letters to the editor are presented including one on the lack of moral courage in U.S. military to solve the sexual abuse crisis, other on stripping commanders of handling sex crimes allegedly committed by member of their command, and another on keeping U.S. Army smart and strong.

Published
2013

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