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Objective Music is a very crucial art form that can evoke emotions, and the harmonious presence of the human voice in music is an impactful part of this process. As a result, vocals have had some significant effects on contemporary music. The mechanism behind the cochlear implant (CI) recipients perceiving different aspects of music is clear; however, how well they perceive vocal tuning within music it is not well known. Hence, this study evaluated the mistuning perception of CI recipients and compared their performance with normal-hearing (NH) listeners. Study Design, Setting, and Patients A total of 16 CI users (7 cisgender men, 9 cisgender women) and 16 sex-matched NH controls with an average age of 30.2 (±10.9; range, 19-53) years and 23.5 (±6.1; range, 20-37) years, respectively, were enrolled in this study. We evaluated the mistuning ability using the mistuning perception test (MPT) and assessed self-perceived music perception and engagement using the music-related quality-of-life questionnaire. Test performance was measured and reported on the item-response theory metric with a z score ranging from -4 to +4. Results A significant difference in the MPT scores was found between NH and CI recipients, whereas a significant correlation was noted between the music-related quality-of-life questionnaire-frequency subscale and MPT scores. No significant correlations were found between age, CI age, and CI usage duration and MPT performance. Conclusions This study revealed that musical mistuning perception is a limitation for CI recipients, similar to previously evaluated aspects of music perception. Hence, it is important to consider this aspect in the assessment of music perception, enjoyment, and music-based auditory interventions in CI recipients, as vocals are paramount in music perception and recreation. The MPT is a convenient and accessible tool for mistuning assessment in CI and hearing-aid users.

Objective: The chronicity of the problem of conductive pathologies, the lack of improvement with treatment, and the progression of hearing loss are seen as important criteria for using hearing aids. The aim of this study was to investigate the effect of conductive pathologies and the use of hearing aids on temporal processing.

PurposeTo investigate the role of non-echo planar diffusion weighted imaging (DWI) using \"periodically rotated overlapping parallel lines with enhanced reconstruction\" (PROPELLER) sequence for the diagnosis of cholesteatoma compared to surgical and histopathological results in an attempt to determine the factors causing false negative and false positive diagnoses.MethodsPatients who had PROPELLER DWI before ear surgery were retrospectively reviewed. The presence of a lesion with diffusion restriction on PROPELLER DWI was accepted as positive for cholesteatoma, and the results were compared to the intraoperative and histopathological findings.ResultsA total of 112 ears in 109 patients were reviewed. On PROPELLER DWI, a lesion with diffusion restriction was found in 101 (90.2%) ears, while in 11 (9.8%) of the patients, no diffusion restriction was found. Surgery and histopathological analysis revealed a cholesteatoma in 100 (89.3%) ears, while in 12 (10.7%) ears, no cholesteatoma was found surgically. There were 96 (85.7%) true positives, 7 (6.2%) true negatives, 5 (4.5%) false positives and 4 (3.6%) false negatives. The accuracy, sensitivity, specificity, positive predictive and negative predictive values of non-echo planar DWI were calculated to be 91.96%, 96%, 58.33%, 95.05%, and 63.64%, respectively.ConclusionNon-echo planar DWI using PROPELLER sequence has high accuracy, sensitivity and positive predictive value and can be used for the detection of cholesteatoma. The external auditory canal, postoperative ears and small lesions should be evaluated with caution to avoid false results.

© 2021The aim of this study was to investigate the effect various mediators in synovial fluid (SF) on the pathogenesis of temporomandibular disorders (TMD) and to evaluate the relationship between clinical and radiological features of temporomandibular joint (TMJ) diseases. Patients who had received SF sample during arthrocentesis because of TMD were included in this study. Clinical and radiological records were evaluated retrospectively. Enzyme-Linked ImmunoSorbent Assay (ELISA) method was used for analysis of aggrecan, adiponectin, resistin, apelin, Vascular Endothelial Growth Factor (VEGF) and Prostaglandin E2 (PGE2) in SFs. 59 joints of 41 patients were included in the study. Anterior disc displacement with reduction (ADDwR) was detected in 22 joints, anterior disc displacement without reduction (ADDwoR) was detected in 29 joints and osteoarthritis (OA) in 8. In OA group, PGE2 level was significantly higher than the other groups (p = 0.029). Aggrecan and PGE2 levels were statistically higher in joints with localized pain (p = 0.030, p = 0.029). The aggrecan level was statistically significant higher in patients who had degenerative changes in radiological examinations (p = 0.044). Resistin was correlated with PGE2 and aggrecan (p = 0.011), and apelin showed positive correlation with VEGF (p˂0.001). The detection of aggrecan and adipokines in SF may be a precursor of degenerative joint disease and it should be taken into account that the presence of localized pain in the joint area may be an early sign of degenerative changes.

Background: Most of the studies on salivary gland cancers are limited for various reasons such as being single-center, small number of patients, including only major or minor SGCs, or only including epidemiological data. Methods: A total of 37 medical oncology clinics from different regions of Turkey participated in this retrospective-multicenter study. The analyzed data included clinical and demographical features, primary treatment, metastasis localizations, and treatments and includes certain pathologic features. Results: The study included data from a total of 443 SGCs. 56.7% was in major salivary glands and 43.3% was in minor salivary glands. Distant metastasis in the major SGCs was statistically significantly more common than in the minor SGCs, locoregional recurrence was statistically significantly more common in the minor SGCs than in the major SGCs (p = 0.003). Conclusions: Epidemiological information, metastasis and recurrence patterns, treatment modalities, and survival analysis of the patients over 20 years of follow-up are presented.

© 2023 Elsevier B.V.Objective: This longitudinal study aimed to investigate the maturational development of P1 latency and the effects of a short inter-implant delay in children who received bilateral sequential cochlear implants. Materials and methods: Fourteen children (first CI mean age: 1.4 ± 0.4 years and Second CI mean age: 3.3 ± 0.5 years) who had received sequential bilateral cochlear implants during the sensitive period for auditory maturation participated in our study. The speech-evoked cortical P1 response was recorded after the activation of the second CI at four intervals (implant activation, 3 months, 6 months, 12 months) under three listening conditions (first CI, second CI, binaural). Results: Our results showed that the P1 latencies of the second CI reached normative values within 3 months, but did not reach the P1 latency of the first CI until 12 months. We found a strong negative correlation between the inter-implant delay and the P1 latencies of the second CI when the second CI was activated. Conclusion: Changes in cortical auditory responses over time resulted in normal auditory maturation in children with sequential bilateral cochlear implants during the sensitive period. The results also provide evidence that the timing of auditory experience in the first ear during the sensitive period may influence the speed of compensation in children receiving sequential cochlear implants.

Objectives. PAX8/PPARG chromosomal rearrangement is frequently seen in thyroid cancer, and PPARG overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of PPARG overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with PPARG overexpression other than the follicular variant. Methods. Immunohistochemical analysis of PPARG overexpression was performed using a PPARG monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma. Results. PPARG staining was detected in 19 of the 111 cases. Sixteen patients with PPARG overexpression had papillary thyroid carcinoma and 3 had follicular adenoma. Conclusion. PPARG overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with PPARG overexpression.

Objective (1) To compare anxiety between parents of newborns with cleft lip and palate (CLP), isolated cleft palate (CP), and healthy newborns and (2) to evaluate anxiety between parental dyads within these groups. Design A cross-sectional study. Setting University Hospital. Participants Surveys were completed by 20 mothers and 20 fathers of newborns with CLP, 21 mothers and 21 fathers of newborns with CP, and 23 mothers and 23 fathers of healthy newborns (controls). Main Outcome Measure The State-Trait Anxiety Inventory (STAI) assessed parental anxiety. Mothers of newborns with a cleft reported on concerns regarding cleft-related issues and facial appearance. Results State and trait anxiety were generally in the moderate range for parents of newborns with a cleft, while control parents had low state anxiety and moderate trait anxiety. Mothers of newborns with CP and CLP had significantly higher state and trait anxiety levels than control mothers ( p Conclusions Parents of children with a cleft may need psychological support in the early postnatal period. It is important for neonatal cleft team providers to help reduce parental anxiety and educate families about cleft care, with a focus on feeding.

Objectives: To develop a reproducible experimental animal model for sulcus vergeture in rabbits. Study Design: Experimental animal study. Material Method: We evaluated three methods of inducing sulcus in twelve New Zealand white rabbits to produce a sulcus model. Experimental groups comprised: group 1 (n = 4) underwent submucosal injury following endolaryngeal epithelial incision; group 2 (n = 4) received submucosal injury via thyrotomy; group 3 (n = 4) received submucosal injury via thyrotomy, followed with horizontal mucosal lateralization suture. Right vocal folds of the rabbits underwent surgery to produce sulcus vocalis and left vocal folds were used for the comparison. In the sixth week after the procedure, the rabbits were sacrificed and the larynxes were harvested and analyzed histopathologically. Results: No animals in group 1 or 2 developed sulcus vocalis. Sulcus formation was observed in all rabbits in group 3, under endoscopic examination and microscopic sulcus formation was demonstrated for the first, second, and third rabbits. An epithelial depression area was seen at the glandular ductal opening zone for the fourth rabbit, but it could also be accepted as a sulcus formation. Conclusion: We successfully developed a reproducible survival model for sulcus using a submucosal injury via thyrotomy, followed with a horizontal mucosal lateralization suture. This model provides the groundwork for future research into the applicability of new approaches for sulcus management.

Nazal dekonjestanların maksiller sinü mukozasındaki antibiyotik konsantrasyonuna etkisi

© 2022 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-FacialObjective: In this study, we created an animal model to demonstrate the effects of thiamine on the hearing pathways of new-borns during pregnancy and lactation by inducing a dietary thiamine deficiency in the mother. Methods: The study included 16 female Wistar albino rats. The animals were separated into four groups and provided the appropriate amounts of dietary thiamine according to their groups during pre-pregnancy, pregnancy, and lactation periods. Three pups from each mother were included in the study, and 12 pups were selected from each group. On the fortieth day after birth, the auditory pathways of 48 pups in the 4 groups were examined electro physiologically and ultra-structurally. Results: In Group N-N, morphology of hair cells stereocilia degeneration was not obtained in all turns of cochlea. In Group N-T, Inner Hair Cells (IHCs) and Outher Hair Cells (OHCs) stereocilia didn\"t show degeneration in all turns of cochlea but had rupture inrows of HCs stereocilia. In group T-N IHCs stereocilia less degeneration was observed in all turns of cochlea. OHC stereocilia partial loss was observed only in basal turn of cochlea. In Group T-T IHCs stereocilia was observed less degeneration and rupture in all turns of cochlea. Conclusion: Thiamine is vital for the development of cochlear hair cells during both prenatal and postnatal periods. Even partial deficiency of thiamine causes significant degeneration to the auditory pathway. Level of evidence: The level of evidence of this article is 5. This article is an experimental animal and laboratory study.

Purpose We investigated the relationship between hearing aid or cochlear implants usage and body image, and quality of life. Methods Of the 96 participants studied, 26 were cochlear implant users, 20 hearing aid users, 20 non-device users with hearing loss, and 30 normal hearing. The inclusion criteria for the study for all groups were subjects 18 years or older with no other physical complaints. The average age of groups and gender distributions were similar. The Body Image Scale (BIS) and World Health Organization Quality of Life Scale were applied to all participants, whereas the International Outcome Inventory for Hearing Aids, Turkish Version, was applied only to device users. Results A significant difference in body image scores was identified between non device users with hearing loss group and normal hearing group, device users group (HA/CI), and cochlear implant users group. In contrast, no significant difference in body image scores between normal hearing group and the device users group was identified. Finally, a positive correlation between body image scores and quality of life scores in all groups was identified. Conclusions Non-device users with hearing loss have a lower body image and quality of life than those in the other groups, and device usage has a positive effect on body image and quality of life.

© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Purpose: We investigated the relationship between hearing aid or cochlear implant use and self-esteem, quality of life, hearing quality, and speech perception. Methods: Of the 120 participants studied, 29 were cochlear implant users, 26 were hearing aid users, 33 were non-device users with hearing loss, and 32 had normal hearing. Each individual included in the study WHOQOL–BREF Quality-of-Life Scale, Rosenberg Self-Esteem and Speech, Spatial Perception and Qualities of Hearing Scale was applied. Results: We found that the self-esteem level of the group with hearing loss, but without a device, was significantly lower than that of the group with a cochlear implant/hearing aid. There was a moderately statistically significant relationship between self-esteem, quality of life, speech perception, and hearing quality. Conclusions: Using hearing aid and cochlear implants increases self-esteem among people with hearing impairments. Self-esteem is associated with quality of life, speech perception, and hearing quality.

Laringomalazi yenidoğan ve infantlarda inspiratuar stridor en sık nedenidir, bu çocukların %10\"unda cerrahi girişim gerektiren ciddi semptomlar mevcuttur. Laringomalazide supraglottik larinksin kollabe olması sonucunda inspiratuar stridor görülür. Tanıda öncelikle fleksibl fiberoptik laringoskop ile değerlendirilme önerilmektedir. Senkronize havayolu lezyonlarının tespiti için bronkoskopi de yapılmalıdır. Laringomalazi şiddeti; hafif, orta ve ağır olarak değerlendirilir. Hafif, orta ve şiddetli olgular için ise asit süpresyon tedavisi, yutma terapisi ve yutmanın değerlendirilmesi tavsiye edilmiş olup; şiddetli laringomalazide laringoskopi/bronkoskopi sonrasında supraglottoplasti tavsiye edilmiştir. Supraglottoplasti laringomalazili çocukların çoğunluğunda başarı ile sonuçlanır. Ancak eşzamanlı havayolu patolojileri ve komorbid hastalıkların varlığı olumsuz sonuçlara neden olabilir ve trakeostomi gerektirebilir. Laryngomalacia is the most common cause of inspiratory stridor in neonates and infants, with 10% of these children having severe symptoms requiring surgical intervention. Inspiratory stridor is seen as a result of collapse of the supraglottic larynx in laryngomalacia. In the diagnosis, evaluation with a flexible fiberoptic laryngoscope is recommended. Bronchoscopy should also be performed to detect synchronous airway pathologies. Laryngomalacia severity; rated as mild, moderate and severe. Acid suppression therapy, swallowing therapy and evaluation of swallowing were recommended for mild, moderate and severe cases; Supraglottoplasty is successful in the majority of children with laryngomalacia. However, the presence of syncronous airway pathologies and comorbid conditions may result worse outcomes and may require tracheostomy.

Subglottik stenoz (SGS), çocukluk çağında kronik üst solunum yolu obstrüksiyonunun en sık nedenlerinden biridir. Konjenital veya edinsel nedenlerle oluşabilir. En sık endotrakeal tüp veya trakeostominin oluşturduğu hasara bağlı anormal yara iyileşmesi sonucu oluşmaktadır. Bu nedenle; tanısında ayrıntılı anamnez önemlidir. Risk faktörleri varlığında SGS araştırılmalıdır. Stridor en sık semptomdur ancak diğer solunum sistemi bulguları ile de karşımıza çıkabilir. Tanıda öncelikle laringoskop ile değerlendirilme önerilmektedir. Laringoskopi ile tanı koyulamadığında bronkoskopi ikinci basamak tanı yöntemi olarak tercih edilmelidir. Darlığın şiddetine göre farklı tedavi protokolleri uygulanır. Hafif darlığı olan vakaların çoğunda konservatif yaklaşım yeterli iken, orta ve şiddetli subglottik stenoz tedavisinde genellikle cerrahi gereklidir. Pediatrik hastalarda subglottik stenozun (SGS) değerlendirilmesi ve yönetimi karmaşık ve teknik olarak zor olduğundan uzmanlaşmış bir ekip ile multidisipliner yaklaşım gerektirir. Subglottic stenosis (SGS) is one of the most common causes of chronic upper airway obstruction in childhood. It can occur due to congenital or acquired reasons. It most commonly occurs as a result of abnormal wound healing due to damage to the endotracheal tube or tracheostomy. Therefore, detailed anamnesis is important in the diagnosis. In the presence of risk factors, SGS should be investigated. Stridor is the most common symptom, but it may also present with other respiratory system findings. In the diagnosis, it is recommended to evaluate with laryngoscope first. When the diagnosis cannot be made by laryngoscopy, bronchoscopy should be preferred as a second-line diagnostic method. Different treatment protocols are applied according to the severity of the stenosis. While the conservative approach is sufficient in most cases with mild stenosis, surgery is usually required for the treatment of moderate to severe subglottic stenosis. The assessment and management of subglottic stenosis (SGS) in pediatric patients is complex and technically challenging, requiring a multidisciplinary approach with a specialized team.

Cerrahi dalların uzmanlık eğitiminin gerçekleştirildiği ameliyathane ortamı başarılı bir cerrahi eğitiminin en önemli bileşenidir. Ancak ülkemizde cerrahi dallardaki uzmanlık öğrencilerinin ameliyathane eğitiminde, programın amacına uygun olarak sistematik ve yapılandırılmış bir program izlemekten çok ”geleneksel usta / çırak” modeliyle karşı karşıyadırlar. Bu yazıda 41. Türk Ulusal Kulak Burun Boğaz ve Baş Boyun Cerrahisi Kongresinde düzenlenmiş olan “Ameliyathane Eğitiminde Sorunlar ve Öneriler” başlıklı paneldeki konuşmalar özetlenmiştir. Kulak Burun Boğaz uzmanlık eğitimindeki öğrencilerin ve eğiticilerin bakış açısı ile sorunlar ve olası çözüm önerileri dile getirilmiştir.

© 2022 Elsevier LtdObjectives: The thyroid imaging reporting and data system (TI-RADS) and 2015 American Thyroid Association (ATA) guidelines are two well-known risk stratification systems for classifying thyroid nodules based on cancer risk. This study aims to evaluate the diagnostic efficacy of these two systems in predicting malignancy in patients undergoing thyroid surgery. Methods: We studied data on 120 individuals who were scheduled to undergo surgery for benign or malignant nodular diseases of the thyroid gland between October 2017 and October 2019. The TI-RADS category and ultrasound pattern based on ATA guidelines were assigned to dominant thyroid nodule categories by two experienced radiologists blinded to patients’ previous thyroid ultrasonography and fine-needle aspiration biopsy results. A pathologist with experience in thyroid diseases blinded to patients’ sonographic and clinical data reviewed the thyroidectomy specimens. Results: A total of 120 patients, 88 women and 32 men, were included in our study. Final histopathological results were as follows: 50% (n=60) papillary thyroid carcinoma, 36.6% (n=44) benign nodular thyroid diseases, 4.1% (n=5) follicular adenoma, 2.5% (n=3) hurtle cell adenoma, 1.7% (n=2) follicular thyroid carcinoma, 1.7% (n=2) medullary thyroid carcinoma, 1.7% (n=2) hurtle cell carcinoma, and 1.7% (n=2) follicular tumor of uncertain malignancy potential. The sensitivity, specificity, positive predictive value, and negative predictive value for TI-RADS were 80%, 56%, 72%, and 67%, respectively, and that for ATA were 80%, 64%, 76%, and 69%, respectively. Conclusion: The TI-RADS and ATA showed similar rates of sensitivity, specificity, NPV, and PPV. Our observed risk of malignancy was higher than expected for the ACR TI-RADS 3–5 categories and the very low, low, and intermediate suspicion risk strata in the ATA guidelines. We found no difference between observed and expected malignancy risk for the ACR TI-RADS 2’s and ATA\"s high suspicion categories.

The majority of the tissues and organs that fall into the area of expertise of ear, nose and throat (ENT) specialists are adjacent to the orbit, and therefore to the globe. As a result of this contiguity, ENT diseases can spread to the orbit and present with various orbital complications. While these complications can be mild, they can also manifest as severe morbidities that lead to permanent loss of vision. In addition, ENT diseases can also spread to the cranium as well as the orbit, and lead to severe intracranial complications that may result in mortality. Such intracranial complications may also manifest with findings in an ophthalmological examination, as many cranial nerves (CNs) are also associated with the orbital structures. This is why ENT specialists commonly encounter ophthalmological findings as a result of both the orbital and cranial complications of infectious ENT diseases. In addition, ophthalmological examination findings are useful for diagnosis, as some infectious agents can cause a common infection both in the ocular and head-neck regions.

The majority of the tissues and organs that fall into the area of expertise of ear, nose and throat (ENT) specialists are adjacent to the orbit, and therefore to the globe. As a result of this contiguity, ENT diseases can spread to the orbit and present with various orbital complications. While these complications can be mild, they can also manifest as severe morbidities that lead to permanent loss of vision. In addition, ENT diseases can also spread to the cranium as well as the orbit, and lead to severe intracranial complications that may result in mortality. Such intracranial complications may also manifest with findings in an ophthalmological examination, as many cranial nerves (CNs) are also associated with the orbital structures. This is why ENT specialists commonly encounter ophthalmological findings as a result of both the orbital and cranial complications of infectious ENT diseases. In addition, ophthalmological examination findings are useful for diagnosis, as some infectious agents can cause a common infection both in the ocular and head-neck region.

© 2022 Elsevier Inc.Objective: The aim of this study is to propose a new approach in crooked nose deformity with key-stone plasty and asymmetric hump resection. Method: Twelve patients with crooked nose deformities were operated using the open rhinoplasty technique. Our method, unlike other methods, has two different steps. Following asymmetric hump resection, cartilaginous and osseous septum were cut separated at the key stone area or more caudally and fix the septum with sutures again by allowing them to slide over each other in a way that directs the septum to the midline. If there is an inability to reveal the septum, we apply a longer spreader graft to the cartilage septum side. Results: The mean ages were 27.4 years. The mean follow-up time of the patients was 19.1 months. No complications were observed due to this technique. This technique was effective in the treatment of all our patients with crooked nose deformities. Conclusion: A novel surgical approach with key-stone plasty and asymmetric hump resection method was proposed in crooked nose deformity with a video animation.

In this study, we evaluated the cochlea, medial olivocochlear system, and brainstem function in autistic children using evoked otoacoustic emissions (OAEs) and a noninvasive contralateral suppression (CLS) test. In total, we included 21 autistic children with normal hearing (study group) and 11 healthy children (control group). Transient-evoked OAEs (TEOAEs) and CLS of TEOAE were evaluated in the left and right ears of all patients. In a silent room, spontaneous, transient, and dP ILO292 were evaluated. The mean age of the study and control group was 9.1 years (range: 6-13 and 6-12 years, respectively). For the study group, there was no statistically significant difference between the OAE and CLS values of the right ear ( P > .05). However, for the left ears, OAE values were statistically significantly higher than the CLS values ( P < .05). In the control group, the OAE values of both ears were statistically significantly higher than the CLS values ( P < .05). In autistic children with normal hearing, the medial olivocochlear system functions more effectively in the right ear than the left ear. Asymmetry between the ears is likely responsible for the peripheral auditory lateralization and independence in auditory function between the left and right ears.

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Seröz otitis mediada medikal tedaviye cevap vermeyen durumlarda ventilasyon tüpü uygulanmaktadır. Böylece orta kulak ventilasyonu sağlanmaktadır. Orta kulak ventilasyonun 2-3 hafta yeterli olduğu düşünüldüğünde ventilasyon tüpü uygulamasının getirdiği riskler ve komplikasyonlar nedeniyle alternatif yöntemler araştırılmaktadır. Bu alternatif yöntemler arasında termal miringotomiler, lokal Mitomisin C ve 5 Floururasil uygulamaları sayılabilir. Bu çalışmada, daha önceki çalışmlarda perforasyon süresini arttırdığı tespit edilmiş olan Mitomisin C ile bu konuda hakkında çok az çalışma yapılmış olan Kolşisin karşılaştırılmış ve Kolşisin'in Mitomisin C' nin alternatifi olup olmadığı incelenmiştir.Çalışmamızda 30 adet Wistar cinsi sıçan kullanıldı. Hayvanlar 10'ar adet 3 gruba ayrıldı. Bir grubun sağ ve sol kulaklarına Mitomisin C, diğer gruba Kolşisin lokal olarak perforasyona uygulandı. 3. grup ise kontrol grubu olarak ayrıldı ve serum fizyolojik sürüldü. Hayvanlar haftalık olarak mikroskop altında kontrol edildi ve perforasyonların kapanma süreleri Kaplan-Meier Survival istatistik tekniği kullanılarak karşılaştırıldı.Perforasyonların kapanma süreleri Mitomisin C grubunda 4,9 hafta, Kolşisin grubunda 3,1 hafta, kontrol grubunda 1,1 hafta olarak tespit edildi. Mitomisin C ve Kolşisin grupları kontrol grubuyla karşılaştırıldığında istatistiksel olarak perforasyon kapanmasını anlamlı derecede uzattığı tespit edildi. Bu iki grup arasında Mitomisin C'nin Kolşisin'e oranla istatistiksel olarak anlamlı deredece daha çok uzattığı tespit edildi. Mitomisin C grubuna ait kulaklardan birinde perforasyon kapanmadı.Mitomisin'in perforasyon kapanma sürelerine olan etkisi Kolşisin'e oranla daha çok etkili olmasına rağmen Kolşisin'in de etkili ve yeterli olduğu saptandı. Böylece ventilasyon tüpüne alternatif daha ucuz, daha güvenilir bir madde olabileceği görüldü.Anahtar Sözcükler: Miringotomi, Mitomisin C, Kolşisin Myringotomy and ventilation tube insertion is most effective surgical treatment modality of serous otitis media that is unresponsive to medical treatment. So middle ear ventilation provided. 2 or 3 weeks of continuous aeration of middle ear is thought to be suffcient in treating serous otitis media. However, high incidence of complications of ventilation tube insertion is the reason fort he searching of alternative surgical procedures. Recent studies have showed that application of topical Mitomycin C or 5- Flourouracil to myringotomies can lengthen the closure time of perforations and termal myringotomies. The aim of the present study was to compare the effects of topically applied Mitomycin C and Cholchisine on potency time of perforations and investigate whether this technique can be an alternative precedure to ventilation tube insertion by the information gathered from this study.This study was performed on 30 healty Wistar rats. Myringotomies were performed under general anesthesia. Mitomycin C pledgets were applied to the right and left ears of 10 rats and Cholchicine were applied to the right and left ears of 10 rats. 10 rats were selected as a control group. Animal were monitonied using otomicroscopy weekly and Kaplan - Meier survival tecnique were used to compare patency time between groups.The mean patency time was 4,9 weeks in Mitomycin C, 3,1 weeks in Cholchicine group and 1,1 weeks in control group. The test showed the study groups to have significantly longer patency then the control group. Allthrough the patency rate of Mitomycin C group was longer than Cholchicine group, the difference between these groups was statistically significant. One permanent perforation occured in mitomycin group.Mitomycin C and Cholchicine application to myringotomies prolongs myringotomy patency time and be proposed as an alternative to the ventilation tube insetion technique especially for indications that need short ventilation time .Keywords: Myringotomy, Mitomycin C, Cholchicine 49

Prof.Dr. i. Nazmi HOŞAL tarafından kurulan ve kurulduğu tarihten itibaren yurdumuzda Kulak Burun Boğaz Baş Boyun Cerrahisi, Maksillo Fasial Cerrahi ve Odyoloji çağdaş tanı ve tedavi prensiplerini uygulamaya sokan, temel prensipleri yerleştiren, bazı uygulamalarda dünya tıb­bının önünde gitmeyi başaran kliniğimiz, geçen yıllar içinde edindiği birikim ile bir ekol oluş­turmuş ve dünya KBB Camiası içinde hak ettiği yeri almıştır. Bu konuda bir model oluşturan Ha­cettepe Üniversitesi Tıp Fakültesi Kulak-Burun-Boğaz Baş Boyun Cerrahisi Kliniği yeni gelişmeler, bilimsel araştırmalar ve yurt dışı temaslar ışığında kendi uygulamalarında da bazı değişik­liklere gitmiştir. Bu nedenle hem kliniğimiz hem de Hacettepe ekolünü takip eden alümni üyelerimiz ve di­ğer meslektaşlarımız açısından son uygulamalarımızı uniform hale getirmek, ortak yaklaşım oluşturmak ve kendilerini bilgilendirmek amacıyla Hacettepe ekolünün en son uygulamaları­nı, KBB tanı ve tedavi prensiplerini güncelleyen bir kitap hazırlanması gereksinimi doğmuştur. Anabilim Dalımız ve Odyoloji Bilim Dalımız öğretim üyelerinin ve araştırma görevlerinin katıl­dığı tartışmalar sonucunda Hacettepe bünyesinde çalışan ve Hacettepe ekolünü takip eden meslektaşlarınızın aynı uygulamaları yapması kararına varılmış, yaklaşık 3 yıl süren çalışmalar ve tartışmalar sonucunda tanı ve tedavi uygulamalarının ana hatları oluşturularak yazılı hale geti­rilmiştir. Hacettepe ruhu yeniden oluşturulmuştur. Bu vesile ile emeği geçen tüm meslektaşlarımıza, öğretim üyelerimize ve araştırma görevlileri­ne teşekkür eder, faydalı olması dileğiyle saygılar sunarım

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[Özet Yok] Dicle Üniversitesi

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Anatomik, fizyolojik ve sosyal ozellikleri nedeni ile yuzy~l~a~k~n bir sureden beri hekimlerin ugra~ kaynaklar~ndan biriniolu~turan RLS paralizilerine ili~kin bir cozum aray~~~ ileduzenlenen bu cal~emada, RLS kesildikten sonra distal ucu vagustakibir centige dikilmietir. Kontrol grubunu olueturan dorts~can d~~~nda 17 s~canda da anastomoz olueturulmu~tur. Histopatolojikincelemelerin sonucunda ise anastomoz alan~nda siniraleyhine onemli geli~imler gozlenmekle birlikte, posteriorcricoarytenoid kaslnda innervasyon bulgular~n~n saptanm~e olmas~ve bu sonuclar~n istatistik korrelasyonlar~ bu yontemin arzulanansonucu verdigini gostermektedir. 61

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