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The aim of this systematic review is to evaluate the efficacy and safety of omalizumab among adult patients with chronic idiopathic/spontaneous urticaria (CIU/CSU).

The aim of this overview of reviews and systematic review update is to identify evidence on the effectiveness of stop smoking interventions for adults for the Canadian Task Force on Preventive Health Care (CTFPHC) and their stop smoking guideline for primary care providers.

The aim of the two systematic reviews is to identify evidence on the benefits and harms of screening for depression in pregnant and postpartum women and in the general adult population for the Canadian Task Force on Preventive Health Care (CTFPHC) and their depression screening guideline for primary care providers.

To inform recommendations by the Canadian Task Force on Preventive Health Care on potentially inappropriate prescriptions and over-the-counter (OTC) medication use among adults aged 65 years and older in relevant primary care settings. The evidence synthesis will review the 1) benefits and harms and 2) acceptability of interventions to reduce potentially inappropriate prescriptions and over-the-counter medication use. Key question 1: What are the benefits and harms of interventions to reduce potentially inappropriate prescriptions and over-the-counter medication use in adults aged 65 and older? Key question 2: What is the acceptability of interventions to address potentially inappropriate prescriptions and over-the-counter medication use in adults aged 65 and older?

The aim of this systematic review update is to identify evidence on the benefits and harms of screening for depression in children and adolescents for the Canadian Task Force on Preventive Health Care (CTFPHC) and their depression screening guideline for primary care providers.

The aim of this scoping review is to identify current firearm legislations and their impact on the rates of suicide, femicide (intentionally killing a woman or girl on account of their gender), homicide, and mass shootings in Canada and internationally. We will also identify factors that have improved or hindered the uptake of Canadian and international firearm legislation. The key questions (KQ) guiding this scoping review are: KQ1a) What Canadian and International firearm legislations have been evaluated for their impact on suicide, femicide, homicide, and mass shooting rates in Canada and internationally? KQ1b) What has been the impact of Canadian and International firearms legislation on rates of death by suicide, femicide, homicide, and mass shootings? KQ2) What factors have improved or hindered the uptake of Canadian and international firearm legislation?