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Germanic languages have been recognized as having not only intensifying or focus particles, but also so-called modal particles. The relevant items are specialized discourse markers joined by characteristic syntactic properties. After an introductory overview of the complex field, the contributions of the current volume capitalize on, but also work much further beyond the baseline of the established insights. They offer analyses of (a) new data types within and sometimes across several Germanic languages (e.g. varieties/stages of German, Dutch, or Norwegian), encompassing different classes of particles and a variety of syntactic-semantic as well as usage-based aspects; (b) the classical dichotomy between languages like German and English when it comes to the availability of modal particles both synchronically and diachronically; (c) crucial integrated insight from non-Germanic languages such as French, Hungarian, Italian, Mandarin, or Vietnamese. A number of mostly interface-based proposals of several languages as well as further generalizations are put on the table for both expert and novice readers in the field.

The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields.

Irre Abenteuer mit Torsten und Rainer: urkomisch! Torsten Brettschneiders urkomische Wahnsinnstrips: jetzt als eBundle. Elchscheiße: Man ist niemals zu jung für eine Midlife Crisis: Torsten Brettschneider, Mitte dreißig, beschließt sein Leben umzukrempeln. Er kündigt seinen durchschnittlichen Job und tritt sein unerwartetes Erbe an: ein Bauernhof in Mittelschweden. Der perfekte Ort, um sich endlich den langjährigen Traum der Schriftstellerei zu erfüllen, findet Torsten. Doch seine Freundin Tanja findet das ganz und gar nicht und brennt lieber mit Torstens Therapeuten durch. Im Land der Elche angekommen, lässt die Postkartenidylle jedoch auf sich warten … Älgskit! Was für eine Elchscheiße! Ob Torsten aus der Schwedennummer je wieder rauskommt? Kaimankacke: Lieber ‘ne Piña Colada in der Karibik bei dreißig Grad im Schatten als stinkenden Fisch bei schwedischem Dauerregen. Dazu: Sonne, Bikinis und so weiter. Gedacht, getan. Kurzentschlossen bucht Torsten Brettschneider Flug und Club-Hotel, besorgt für alle Fälle noch schnell zwei Badehosen und fliegt über den Großen Teich, wo ihn neben seinen Gödseltorp-Kampfgenossen Rainer und Bjørn einige Überraschungen erwarten. Der Kaiman im Swimmingpool ist dabei erst der Anfang … Rentierköttel: Torsten Brettschneider muss die Renovierungsarbeiten an seinem Ferienhaus unterbrechen, um seine Angebetete Linda zu suchen. Die ist Richtung Lappland verschwunden. In der Zwischenzeit soll Torstens Vater Gerd, seines Zeichens Ingenieur und Frührentner, die Bauarbeiten am Ferienhaus leiten … Torsten und Rainer machen sich auf in die eisige Einsamkeit Lapplands und geraten prompt an eine Asen-Sekte. Die Mitglieder sind davon überzeugt, die Reinkarnationen nordischer Götter zu sein. Von Linda nach wie vor keine Spur … Dann macht sich auch noch Gerd auf den Weg, um dem Sohnemann zu helfen.

Gödseltorp war gestern: Auf nach Lappland! Neue Lachfalten für Schwedenfans! Wenn es bei Torsten schlecht läuft, dann gleich doppelt: Haus marode, Freundin verschwunden! Gemeinsam mit Chaos-Kumpel Rainer macht er sich auf die Suche nach Linda, Richtung Lappland, wo sie an eine durchgeknallte Asen-Sekte geraten. Die beiden geben vor, »welche von ihnen« zu sein …

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency. Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attrition Tackles a problem that adds billions of dollars to drug development programs and health care costs Guides discovery and development scientists through R&D stages, teaching requirements and reasons why drugs can fail Discusses potential ways forward utilizing new approaches and opportunities to reduce attrition

Although less common than a-amino acids, non-a-amino acids-where the amino group is not on the carbon immediately adjacent to the carboxyl group but is attached to another carbon in the chain (for example, the �, d carbon)-are components of biologically important molecules, are significant in the pharmaceutical industry, and are useful starting ma

The new, revised and updated 7th edition of March's Advanced Organic Chemistry clearly explains the theories and examples of organic chemistry, providing the most comprehensive resource about organic chemistry available. Readers are guided on planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions. The first five chapters deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Chapters 6 to 9 are concerned with general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation, and finally the relationship between structure and reactivity. The last 10 chapters cover the nature and the scope of organic reactions and their mechanisms. The 7th edition proves again it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Key features of the 7th edition: Every chapter has been updated with the most recent reaction information with references to both the primary and review literature New to the 7th edition: 5,500 references since the last edition, updates / rewrites of the retained sections, and an updated index in Appendix B Contains more than 1650 reactions and 20,000 valuable references to the primary literature Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds synthesized Guides the reader on planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions. Reviews of the previous edition:'...a favorite general organic chemistry text and an easy-to-use one-volume reference. We are confident that this book will remain a dominant reference and that it will reside on many chemists'personal bookshelves.'–Journal of Medicinal Chemistry'Who can hope to be seriously accepted as a member of the organic chemistry community without being in possession of at least one edition of'March'?'–Chemistry and Industry

Over the last three decades the importance of organosilicon chemistry has greatly increased because it has opened a number of new synthetic strategies. Silicon reagents are usually low-cost, versatile and allow a wide range of reactions. This is the first Handbook to compile essential Silicon containing reagents and makes use of the leading reagent database e-EROS. Another hot volume in the series Handbooks of Reagents for Organic Synthesis, this is a must-have resource for all synthetic chemists working in drug development and medicinal chemistry. For the selection the Editor focussed on three key synthetic approaches with the greatest impact: 1. Use of silicon as a'temporary tether'by unifying a reactive pair of functional groups and taking advantage of their template-biased intramolecular cyclization. 2. The specific use of the silane functionality as a hetero t-butyl group, often colloquially referred to as the use of silicon as a'fat proton'. 3. The use of the Brook rearrangement as an'anion relay stratagem'. A new feature in this Handbook is the reagent finder, an alphabetically organized lookup table arranged by organic functionality and specific structure of the silicon atom to which it is bound.

Vectorworks® ist das meist genutzte CAD-Programm für Apple und eines der führenden für Windows. Mit dem Buch lernen Architekten, Innenarchitekten, Bühnen- und Szenenbildner sowie Studierende das Programm noch besser kennen. Zu Beginn werden Leser in Programmoberfläche, Werkzeuge, Strukturhilfen, Standardzeichentechniken und -translationsoperationen eingeführt, wobei die 3D- und 2D-Werkzeuge anhand eines Beispielprojekts vorgestellt werden. Am Ende steht ein komplettes 3D-Modell des Bauwerks einschließlich davon abgeleiteter Pläne.

There are a lot of books available about the chemistry and biology of sulfur. However, this is the first book with a compilation of all relevant Sulfur containing reagents. Synthetic chemists, most particularly in the medicinal and pharmaceutical chemists, are often called upon to prepare compounds that contain Sulfur as a key structural feature. In the past, this seemed to be a domain for specialists; today every synthetic chemist working in these area is expected to synthesize compounds containing sulfides, sulfates, sulfones, etc. This book offers an important source of information for the selection and handling of the right reagents.

More than a one-volume listing of synthetic methods, Compendium ofOrganic Synthetic Methods offers chemists a highly focused andselective look at several thousand functional grouptransformations. Used by more professionals than any comparablereference on the market, this valuable desktop resource providesquick access to the recipes of the newest, most useful reactionsand transformations. It also affords professionals an unparalleledopportunity to browse the vast body of recent literature for newreactions and transformations that may be of interest. Featuring 1,200 more entries than its predecessor, Volume 8 coversfunctional group transformations and carbon-carbon bond formingreactions appearing in the literature from 1990 through 1992. Itpresents approximately 1,400 examples of published reactions forthe preparation of monofunctional compounds and approximately 1,640examples of reactions that prepare difunctional compounds withvarious functional groups. It also features 60 more reviews thanVolume 7. As in all the previous Compendium volumes, the classificationschemes used allow for quick and easy reference and informationretrieval. Chemical transformations are classified first by thereacting functional group of the starting material and then by thefunctional group formed. The transformation, major reagents thateffect the transformation, yield percentage, and stereochemistryare all clearly shown. The Compendium also includes indices forboth monofunctional and difunctional compounds as an efficientmeans of guiding you to specific classes of transformations. Compendium of Organic Synthetic Methods, Volume 8 providesprofessional chemists and students unparalleled access to thewealth of methods, reactions, and transformations in contemporaryorganic chemistry.

The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. Each successive edition of March's continues to garner international praise. Here is what one reviewer said of the Fifth Edition:'The book remains a tremendous value for the money... more pages per buck than most other texts... so it will remain a firm favorite as a general organic text and an easy-to-use one-volume reference... it will undoubtedly appear in all organic chemistry libraries and probably on many chemists'personal bookshelves too.'—Organic Process Research & Development The Sixth Edition carries on the tradition of excellence with such new features as: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations