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46 results on '"KOPP, UTE A."'

1. Correction: Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

Author

Wirth, Miranka, Schwarz, Claudia, Benson, Gloria, Horn, Nora, Buchert, Ralph, Lange, Catharina, Köbe, Theresa, Hetzer, Stefan, Maglione, Marta, Michael, Eva, Märschenz, Stefanie, Mai, Knut, Kopp, Ute, Schmitz, Dietmar, Grittner, Ulrike, Sigrist, Stephan J., Stekovic, Slaven, Madeo, Frank, and Flöel, Agnes

Published
2022
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6. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

Author

Wirth, Miranka, Schwarz, Claudia, Benson, Gloria, Horn, Nora, Buchert, Ralph, Lange, Catharina, Köbe, Theresa, Hetzer, Stefan, Maglione, Marta, Michael, Eva, Märschenz, Stefanie, Mai, Knut, Kopp, Ute, Schmitz, Dietmar, Grittner, Ulrike, Sigrist, Stephan J., Stekovic, Slaven, Madeo, Frank, and Flöel, Agnes

Published
2019
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16. Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult-onset disorder

Author

Schmitz‐Hübsch, Tanja, Lux, Silke, Bauer, Peter, Brandt, Alexander U., Schlapakow, Elena, Greschus, Susanne, Scheel, Michael, Gärtner, Hanna, Kirlangic, Mehmet E., Gras, Vincent, Timmann, Dagmar, Synofzik, Matthis, Giorgetti, Alejandro, Carloni, Paolo, Shah, Jon N., Schöls, Ludger, Kopp, Ute, Bußenius, Lisa, Oberwahrenbrock, Timm, Zimmermann, Hanna, Pfueller, Caspar, Kadas, Ella‐Maria, Rönnefarth, Maria, Grosch, Anne‐Sophie, Endres, Matthias, Amunts, Katrin, Paul, Friedemann, Doss, Sarah, and Minnerop, Martina

Subjects
Adult, Male, genetics [Protein Kinase C], physiopathology [Spinocerebellar Ataxias], Neurosciences. Biological psychiatry. Neuropsychiatry, Cross-Sectional Studies, Disease Progression, Humans, Spinocerebellar Ataxias, diagnosis [Spinocerebellar Ataxias], Female, Neurology. Diseases of the nervous system, ddc:610, genetics [Spinocerebellar Ataxias], Prospective Studies, Age of Onset, Function and Dysfunction of the Nervous System, RC346-429, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Research Articles, Protein Kinase C, RC321-571, Research Article
Abstract

Annals of Clinical and Translational Neurology 8(4), 774-789 (2021). doi:10.1002/acn3.51315, Published by Wiley, Chichester [u.a.]

Published
2021
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17. Spinocerebellar ataxia type 14 : Refining clinicogenetic diagnosis in a rare adult-onset disorder

Author

Schmitz-Hübsch, Tanja, Lux, Silke, Bauer, Peter, Brandt, Alexander U., Schlapakow, Elena, Greschus, Susanne, Scheel, Michael, Gärtner, Hanna, Kirlangic, Mehmet E., Gras, Vincent, Timmann, Dagmar, Synofzik, Matthis, Giorgetti, Alejandro, Carloni, Paolo, Shah, Jon N., Schöls, Ludger, Kopp, Ute, Bußenius, Lisa, Oberwahrenbrock, Timm, Zimmermann, Hanna, Pfueller, Caspar, Kadas, Ella-Maria, Rönnefarth, Maria, Grosch, Anne-Sophie, Endres, Matthias, Amunts, Katrin, Paul, Friedemann, Doss, Sarah, and Minnerop, Martina

Subjects
Medizin
Abstract

Objectives: Genetic variant classification is a challenge in rare adult-onset disorders as in SCA-PRKCG (prior spinocerebellar ataxia type 14) with mostly private conventional mutations and nonspecific phenotype. We here propose a refined approach for clinicogenetic diagnosis by including protein modeling and provide for confirmed SCA-PRKCG a comprehensive phenotype description from a German multi-center cohort, including standardized 3D MR imaging. Methods: This cross-sectional study prospectively obtained neurological, neuropsychological, and brain imaging data in 33 PRKCG variant carriers. Protein modeling was added as a classification criterion in variants of uncertain significance (VUS). Results: Our sample included 25 cases confirmed as SCA-PRKCG (14 variants, thereof seven novel variants) and eight carriers of variants assigned as VUS (four variants) or benign/likely benign (two variants). Phenotype in SCA-PRKCG included slowly progressive ataxia (onset at 4–50 years), preceded in some by early-onset nonprogressive symptoms. Ataxia was often combined with action myoclonus, dystonia, or mild cognitive-affective disturbance. Inspection of brain MRI revealed nonprogressive cerebellar atrophy. As a novel finding, a previously not described T2 hyperintense dentate nucleus was seen in all SCA-PRKCG cases but in none of the controls. Interpretation: In this largest cohort to date, SCA-PRKCG was characterized as a slowly progressive cerebellar syndrome with some clinical and imaging features suggestive of a developmental disorder. The observed non-ataxia movement disorders and cognitive-affective disturbance may well be attributed to cerebellar pathology. Protein modeling emerged as a valuable diagnostic tool for variant classification and the newly described T2 hyperintense dentate sign could serve as a supportive diagnostic marker of SCA-PRKCG. CA extern

Published
2021

19. Long‐Term Cognitive Outcome in Anti–N‐Methyl‐D‐Aspartate Receptor Encephalitis

Author

Heine, Josephine, Kopp, Ute A., Klag, Johanna, Ploner, Christoph Johannes, Prüss, Harald, Finke, Carsten, Heine, Josephine, Kopp, Ute A., Klag, Johanna, Ploner, Christoph Johannes, Prüss, Harald, and Finke, Carsten

Abstract

Objective Cognitive dysfunction is a core symptom of anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis, but detailed studies on prevalence, characteristics of cognitive deficits, and the potential for recovery are missing. Here, we performed a prospective longitudinal study to assess cognitive long‐term outcome and identify clinical predictors. Methods Standardized comprehensive neuropsychological assessments were performed in 43 patients with NMDAR encephalitis 2.3 years and 4.9 years (median) after disease onset. Cognitive assessments covered executive function, working memory, verbal/visual episodic memory, attention, subjective complaints, and depression and anxiety levels. Cognitive performance of patients was compared to that of 30 healthy participants matched for age, sex, and education. Results All patients had persistent cognitive deficits 2.3 years after onset, with moderate or severe impairment in >80% of patients. Core deficits included memory and executive function. After 4.9 years, significant improvement of cognitive function was observed, but moderate to severe deficits persisted in two thirds of patients, despite favorable functional neurological outcomes (median modified Rankin Scale = 1). Delayed treatment, higher disease severity, and longer duration of the acute phase were predictors for impaired cognitive outcome. The recovery process was time dependent, with greater gains earlier after the acute phase, although improvements were possible for several years after disease onset. Interpretation Cognitive deficits are the main contributor to long‐term morbidity in NMDAR encephalitis and persist beyond functional neurological recovery. Nonetheless, cognitive improvement is possible for several years after the acute phase and should be supported by continued cognitive rehabilitation. Cognition should be included as an outcome measure in future clinical studies. ANN NEUROL 2021;90:949–961, Bundesministerium für Bildung und Forschung http://dx.doi.org/10.13039/501100002347, Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659, Peer Reviewed

Published
2021

24. Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult‐onset disorder

Author

Schmitz‐Hübsch, Tanja, primary, Lux, Silke, additional, Bauer, Peter, additional, Brandt, Alexander U., additional, Schlapakow, Elena, additional, Greschus, Susanne, additional, Scheel, Michael, additional, Gärtner, Hanna, additional, Kirlangic, Mehmet E., additional, Gras, Vincent, additional, Timmann, Dagmar, additional, Synofzik, Matthis, additional, Giorgetti, Alejandro, additional, Carloni, Paolo, additional, Shah, Jon N., additional, Schöls, Ludger, additional, Kopp, Ute, additional, Bußenius, Lisa, additional, Oberwahrenbrock, Timm, additional, Zimmermann, Hanna, additional, Pfueller, Caspar, additional, Kadas, Ella‐Maria, additional, Rönnefarth, Maria, additional, Grosch, Anne‐Sophie, additional, Endres, Matthias, additional, Amunts, Katrin, additional, Paul, Friedemann, additional, Doss, Sarah, additional, and Minnerop, Martina, additional

Published
2021
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31. Interferon-free therapy in hepatitis C virus (HCV) monoinfected and HCV/HIV coinfected patients:Effect on cognitive function, fatigue, and mental health

Author

Kleefeld, Felix, Heller, Sophie, Ingiliz, Patrick, Jessen, Heiko, Petersen, Anders, Kopp, Ute, Kraft, Antje, Hahn, Katrin, Kleefeld, Felix, Heller, Sophie, Ingiliz, Patrick, Jessen, Heiko, Petersen, Anders, Kopp, Ute, Kraft, Antje, and Hahn, Katrin

Abstract

The efficacy and safety of interferon-free therapies for hepatitis C virus (HCV) infection have been reported. Considering the accumulating evidence for a direct central nervous system infection by HCV, we aim to evaluate the effect of direct acting antivirals (DAA) therapy on cognitive function in HCV patients. We conducted a longitudinal analysis of the cognitive performance of 22 patients (8 HCV+, 14 HCV+/HIV+) who completed neuropsychological testing at baseline and at week 12 after DAA therapy. In 20 patients, we analyzed specific attention parameters derived from an experimental testing based on the Theory of Visual Attention (TVA). Depression, fatigue, and mental health were assessed as patient reported outcomes. At baseline, 54.5% of the patients met the criteria for cognitive impairment and 40% showed impairment in TVA parameters. Follow-up analysis revealed significant improvements in the domains of visual memory/learning, executive functions, verbal fluency, processing speed, and motor skills but not in verbal learning and attention/working memory. We did not observe significant improvement in visual attention measured by TVA. Fatigue and mental health significantly improved at follow-up. Our findings indicate that successful DAA treatment leads to cognitive improvements in several domains measured by standard neuropsychological testing. The absence of improvement in TVA parameters and of significant improvement in the domain of attention/working memory might reflect the persistence of specific cognitive deficits after HCV eradication. In summary, DAA treatment seems to have a positive effect on some cognitive domains and leads to an improvement in mental health and fatigue in HCV-infected patients.

Published
2018

33. Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis

Author

Finke, Carsten, Kopp, Ute A, Ploner, Christoph J, Prüß, Harald, Paul, Friedemann, Scheel, Michael, Pech, Luisa-Maria, Soemmer, Carina, Schlichting, Jeremias, Leypoldt, Frank, Brandt, Alexander U, Wuerfel, Jens, and Probst, Christian

Subjects
Adult, Male, pathology [Nerve Net], metabolism [Hippocampus], Neuropsychological Tests, Hippocampus, Severity of Illness Index, Young Adult, methods [Magnetic Resonance Imaging], Leukoencephalopathies, physiopathology [Nerve Net], Humans, ddc:610, physiopathology [Anti-N-Methyl-D-Aspartate Receptor Encephalitis], metabolism [Nerve Net], metabolism [Anti-N-Methyl-D-Aspartate Receptor Encephalitis], physiopathology [Leukoencephalopathies], Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Functional Neuroimaging, pathology [Leukoencephalopathies], pathology [Anti-N-Methyl-D-Aspartate Receptor Encephalitis], Middle Aged, instrumentation [Magnetic Resonance Imaging], Magnetic Resonance Imaging, pathology [Hippocampus], metabolism [Leukoencephalopathies], physiopathology [Hippocampus], Female, Nerve Net
Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis with a characteristic neuropsychiatric syndrome and severe and prolonged clinical courses. In contrast, standard clinical magnetic resonance imaging (MRI) remains normal in the majority of patients. Here, we investigated structural and functional brain changes in a cohort of patients with anti-NMDAR encephalitis.Twenty-four patients with established diagnosis of anti-NMDAR encephalitis and age- and gender-matched controls underwent neuropsychological testing and multimodal MRI, including T1w/T2w structural imaging, analysis of resting state functional connectivity, analysis of white matter using diffusion tensor imaging, and analysis of gray matter using voxel-based morphometry.Patients showed significantly reduced functional connectivity of the left and right hippocampus with the anterior default mode network. Connectivity of both hippocampi predicted memory performance in patients. Diffusion tensor imaging revealed extensive white matter changes, which were most prominent in the cingulum and which correlated with disease severity. In contrast, no differences in T1w/T2w structural imaging and gray matter morphology were observed between patients and controls.Anti-NMDAR encephalitis is associated with characteristic alterations of functional connectivity and widespread changes of white matter integrity despite normal findings in routine clinical MRI. These results may help to explain the clinicoradiological paradox in anti-NMDAR encephalitis and advance the pathophysiological understanding of the disease. Correlation of imaging abnormalities with disease symptoms and severity suggests that these changes play an important role in the symptomatology of anti-NMDAR encephalitis.

Published
2012
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35. Neuropsychological Effects of MRI-Detected Brain Lesions After Left Atrial Catheter Ablation for Atrial Fibrillation

Author

Herm, Juliane, primary, Fiebach, Jochen B., additional, Koch, Lydia, additional, Kopp, Ute A., additional, Kunze, Claudia, additional, Wollboldt, Christian, additional, Brunecker, Peter, additional, Schultheiss, Heinz-Peter, additional, Schirdewan, Alexander, additional, Endres, Matthias, additional, and Haeusler, Karl Georg, additional

Published
2013
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