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4,298 results on '"KOCH W"'

3. 1877–1879

Author

B. Gaupp, A. Hellweg, R. Koch, W. Neubauer, W. L. Solms, R. von Sydow, W. Turnau, F. Vierhaus, B. Gaupp, A. Hellweg, R. Koch, W. Neubauer, W. L. Solms, R. von Sydow, W. Turnau, F. Vierhaus

Published
2021

5. Effect of anticonvulsive treatment on neuropsychological performance in children with BECTS

Author

Baumeister, F.A.M., Baethmann, M., Schreiber-Gollwitzer, B., Bentele, K., Blank, C., Held, J., Blank, H.M., Liebrich, K., Bode, H., Braun, J., Bosch, F., Wagner, R., Brandl, U., Wetzel, K., Brockmann, K., Schlockwerder, C., Dahlem, P., Baudler, I., Ernst, J.P., Mayer, H., Feldmann, E., Pattber-Wolff, A., Fiedler, A., Sonnleitner, S., Gerigk, M., Heß, S., Feiereis, T., Hikel, C., Hoffmann, H.G., Rickeshenrich, A., Kieslich, M., Dewitz, R., Baz Bartels, M., Klepper, J., Kleuker, S., Kluger, G., Kirsch, A., Koch, H., Meerpohl, U., Koch, W., Korinthenberg, R., Stehle-Renner, B., Krois, I., Wegener, A., Kühne, H., Weiß, C., Kurlemann, G., Elkemann, U., Mandl, M., Friedl, A., Mause, U., Müller, M., Navratil, P., Iken, U., Opp, J., Walter, J., Penzien, J., Prietsch, V., Siegrist, B., Quattländer, A., Rating, D., Reuner, G., Schara, U., Shamdeen, M.G., Struchholz, H., Sprinz, A., Wendker-Magrabi, H., Stephani, U., Muhle, H., Carlsson, G., Straßburg, H.M., Ottensmeier, H., Töpke, B., Tatsek, K., Trollmann, R., Poida-Herzing, E., Tuschen-Hofstätter, E., Menschig, M., Waltz, S., Pickartz, A., Weber, G., Gehnen, T., Wien, F.U., Antemann, J., Wolff, M., Serra, E., Polster, T., Freitag, H., Sönmez, Ö, Rheinhardt, K., Traus, M., Schröder, A., Hoovey, S., Navratil, C., Tacke, Moritz, Gerstl, Lucia, Heinen, Florian, Heukaeufer, Isabel, Bonfert, Michaela, Bast, Thomas, Cornell, Sonia, Neubauer, Bernd Axel, and Borggraefe, Ingo

Published
2016
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8. High-throughput isolation of gentiopicroside from Gentiana lutea and the study on its anticancer properties in vitro

Author

Antoniadi, L. Wawruszak, A. Angelis, A. Czerwonka, A. Jarząb, A. Halabalaki, M. Kukula-Koch, W. Skaltsounis, L.A. and Antoniadi, L. Wawruszak, A. Angelis, A. Czerwonka, A. Jarząb, A. Halabalaki, M. Kukula-Koch, W. Skaltsounis, L.A.

Abstract

The study aims at the isolation of gentiopicroside (GPC) from Gentiana lutea L. root extracts. GPC is a bioactive glycosylated secoiridoid from Gentiana spp. (Gentianaceae) proved to exhibit broad pharmaceutical activities, including anti-inflammatory, hepatoprotective and spasmolytic action. Due to its marked potential, an efficient recovery method of high purity GPC from G. lutea roots was elaborated using the combination of Centrifugal Partition Extraction (CPE) that offers the advantage of industrial scalability, and Preparative High Performance Liquid Chromatography (prep-HPLC) techniques. For this purpose the root hydroalcoholic extract of G. lutea was initially fractionated in a 0.3 L volume CPE column using the biphasic solvent system that was composed of heptane: ethyl acetate: ethanol: water 1:8:3:5 (v/v/v/v) in elution-extrusion mode. As a result, 2.2 g of GPC (purity > 90%) and 0.77 g of GPC-enriched fractions (purity > 80%) were obtained from 31.5 g of the extract within 6 h (5 consecutive CPE fractionations). The following prep-HPLC based purification step increased the quantity and purity of the finally isolated secoiridoid to 2.21 g of > 96% pure GPC. The successful recovery of large amounts of pure GPC enabled the study on the anti-proliferative activity against the following cancer and normal cell lines: lung (A549, NCI-H1299), breast (MCF7, MDA-MB-468), glioblastoma (T98G), rhabdomyosarcoma (TE671), colon (HT-29, DLD-1) cancer cells and normal colon epithelial cells (CCD 841 CoTr). The MTT assay enabled the evaluation of the dose-dependent growth inhibition effect that was evident in all analyzed cancer cell lines, however, TE671 cells were the most sensitive (IC50 = 0.078 mg/mL) and MDA-MB-468 cells were the least sensitive (IC50 = 0.208 mg/mL) to the GPC treatment. The tested compound showed only a weak cytotoxic effect against normal cells (CCD 841 CoTr). © 2023 Elsevier B.V.

Published
2023

9. Data from NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva

Author

Guerrero-Preston, R., primary, Soudry, E., primary, Acero, J., primary, Orera, M., primary, Moreno-López, L., primary, Macía-Colón, G., primary, Jaffe, A., primary, Berdasco, M., primary, Ili-Gangas, C., primary, Brebi-Mieville, P., primary, Fu, Y., primary, Engstrom, C., primary, Irizarry, R.A., primary, Esteller, M., primary, Westra, W., primary, Koch, W., primary, Califano, J., primary, and Sidransky, D., primary

Published
2023
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10. Supplementary Tables from NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva

Author

Guerrero-Preston, R., primary, Soudry, E., primary, Acero, J., primary, Orera, M., primary, Moreno-López, L., primary, Macía-Colón, G., primary, Jaffe, A., primary, Berdasco, M., primary, Ili-Gangas, C., primary, Brebi-Mieville, P., primary, Fu, Y., primary, Engstrom, C., primary, Irizarry, R.A., primary, Esteller, M., primary, Westra, W., primary, Koch, W., primary, Califano, J., primary, and Sidransky, D., primary

Published
2023
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11. Supplementary Figures from NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva

Author

Guerrero-Preston, R., primary, Soudry, E., primary, Acero, J., primary, Orera, M., primary, Moreno-López, L., primary, Macía-Colón, G., primary, Jaffe, A., primary, Berdasco, M., primary, Ili-Gangas, C., primary, Brebi-Mieville, P., primary, Fu, Y., primary, Engstrom, C., primary, Irizarry, R.A., primary, Esteller, M., primary, Westra, W., primary, Koch, W., primary, Califano, J., primary, and Sidransky, D., primary

Published
2023
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13. A Security Assistance System Combining Person Tracking with Chemical Attributes and Video Event Analysis

Author

Becher, Christopher, Foresti, G.L., Kaul, Peter, Koch, W., Lorenz, F.P., Lubczyk, D., Micheloni, C., Piciarelli, C., Safenreiter, K., Siering, C., Varela, M., Waldvogel, S.R., Wieneke, M., Zacharias, Christoph, editor, ter Horst, Klaus W., editor, Witt, Kurt-Ulrich, editor, Sommer, Volker, editor, Ant, Marc, editor, Essmann, Ulrich, editor, and Mülheims, Laurenz, editor

Published
2009
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18. Reduced Aspiration Rates for 50 Gy Postoperative Radiation in HPV-Associated Oropharynx Cancer in E3311: A Trial of the ECOG-ACRIN Cancer Research Group

Author

Hutcheson, K.A., primary, Peterson, C.B., additional, Barbon, C.E., additional, Quon, H., additional, Mehra, R., additional, Ringash, J.G., additional, Lewin, J.S., additional, Flamand, Y., additional, Duvvuri, U., additional, Ozer, E., additional, Thomas, G.R., additional, Kupferman, M.E., additional, Koch, W., additional, Bell, R.B., additional, Saba, N.F., additional, Panwar, A., additional, Annino Jr, D.J., additional, Wagner, L.I., additional, Ferris, R.L., additional, and Burtness, B., additional

Published
2022
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21. Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials

Author

Clement Alexander, Koch Wolfgang, Glasmacher Birgit, and Pohlmann Gerhard

Subjects
porous materials, aerosolisation, droplet sizes, aerosol delivery rate, film breakup, Medicine
Abstract

A novel two-phase aerosolisation mode utilizing porous materials is investigated, aiming to improve aerosol delivery for medical inhalation. Sintered stainless steel filters with varied pore sizes (PS) from 0.2 μm to 7 μm were used to generate aerosols from a 0.9 wt.% sodium chloride solution. Droplet sizes and delivery rates were measured using laser diffraction spectroscopy. Further measurements included shadow imaging. Results indicate that aerosolisation occurs within a specific range of PS with droplet sizes increasing with increasing PS. The droplets generated are suitable for inhalation therapies. A hypothesis is established about the process of droplet formation which states that different PS within the porous material serve distinct functions that contribute to the breakup of liquid films into aerosol particles. Droplet formation is the result of film breakup in pores filled with fluid. This low-energy aerosolisation method has the potential to be used in handheld devices for sensitive drug formulations, overcoming the limitations of current technologies. Further research is needed to optimize the pore size distribution and enhance aerosol generation efficiency.

Published
2024
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