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3. Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population

Author

Sakashita, Takuya, Nakamura, Yasuyuki, Sutoh, Yoichi, Shimizu, Atsushi, Hachiya, Tsuyoshi, Otsuka-Yamasaki, Yayoi, Takashima, Naoyuki, Kadota, Aya, Miura, Katsuyuki, Kita, Yoshikuni, Ikezaki, Hiroaki, Otonari, Jun, Tanaka, Keitaro, Shimanoe, Chisato, Koyama, Teruhide, Watanabe, Isao, Suzuki, Sadao, Nakagawa-Senda, Hiroko, Hishida, Asahi, Tamura, Takashi, Kato, Yasufumi, Okada, Rieko, Kuriki, Kiyonori, Katsuura-Kamano, Sakurako, Watanabe, Takeshi, Tanoue, Shiroh, Koriyama, Chihaya, Oze, Isao, Koyanagi, Yuriko N., Nakamura, Yohko, Kusakabe, Miho, Nakatochi, Masahiro, Momozawa, Yukihide, Wakai, Kenji, and Matsuo, Keitaro

Published
2023
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4. The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study

Author

Ohashi, Mizuki, Miura, Katsuyuki, Takashima, Naoyuki, Kadota, Aya, Saito, Yoshino, Tsuji, Shunichiro, Murakami, Takashi, Kadomatsu, Yuka, Nagayoshi, Mako, Hara, Megumi, Tanaka, Keitaro, Tamura, Takashi, Hishida, Asahi, Takezaki, Toshiro, Shimoshikiryo, Ippei, Ozaki, Etsuko, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Kuriki, Kiyonori, Arisawa, Kokichi, Katsuura-Kamano, Sakurako, Yamasaki, Sho, Ikezaki, Hiroaki, Oze, Isao, Koyanagi, Yuriko N., Mikami, Haruo, Nakamura, Yohko, Takeuchi, Kenji, Kita, Yoshikuni, and Wakai, Kenji

Published
2022
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6. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern

Author

Suzuki, Harumitsu, Nakamura, Yasuyuki, Matsuo, Keitaro, Imaeda, Nahomi, Goto, Chiho, Narita, Akira, Shimizu, Atsushi, Takashima, Naoyuki, Matsui, Kenji, Miura, Katsuyuki, Nakatochi, Masahiro, Hishida, Asahi, Tamura, Takashi, Kadomatsu, Yuka, Okada, Rieko, Nishida, Yuichiro, Shimanoe, Chisato, Nishimoto, Daisaku, Takezaki, Toshiro, Oze, Isao, Ito, Hidemi, Ikezaki, Hiroaki, Murata, Masayuki, Matsui, Daisuke, Ozaki, Etsuko, Mikami, Haruo, Nakamura, Yohko, Suzuki, Sadao, Watanabe, Miki, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Momozawa, Yukihide, Kubo, Michiaki, Kita, Yoshikuni, Takeuchi, Kenji, and Wakai, Kenji

Published
2021
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7. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Author

Wen, Wanqing, Kato, Norihiro, Hwang, Joo-Yeon, Guo, Xingyi, Tabara, Yasuharu, Li, Huaixing, Dorajoo, Rajkumar, Yang, Xiaobo, Tsai, Fuu-Jen, Li, Shengxu, Wu, Ying, Wu, Tangchun, Kim, Soriul, Guo, Xiuqing, Liang, Jun, Shungin, Dmitry, Adair, Linda S, Akiyama, Koichi, Allison, Matthew, Cai, Qiuyin, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Yuan-Tsong, Cho, Yoon Shin, Choi, Bo Youl, Gao, Yutang, Go, Min Jin, Gu, Dongfeng, Han, Bok-Ghee, He, Meian, Hixson, James E, Hu, Yanling, Huang, Tao, Isono, Masato, Jung, Keum Ji, Kang, Daehee, Kim, Young Jin, Kita, Yoshikuni, Lee, Juyoung, Lee, Nanette R, Lee, Jeannette, Wang, Yiqin, Liu, Jian-Jun, Long, Jirong, Moon, Sanghoon, Nakamura, Yasuyuki, Nakatochi, Masahiro, Ohnaka, Keizo, Rao, Dabeeru, Shi, Jiajun, Sull, Jae Woong, Tan, Aihua, Ueshima, Hirotsugu, Wu, Chen, Xiang, Yong-Bing, Yamamoto, Ken, Yao, Jie, Ye, Xingwang, Yokota, Mitsuhiro, Zhang, Xiaomin, Zheng, Yan, Qi, Lu, Rotter, Jerome I, Jee, Sun Ha, Lin, Dongxin, Mohlke, Karen L, He, Jiang, Mo, Zengnan, Wu, Jer-Yuarn, Tai, E Shyong, Lin, Xu, Miki, Tetsuro, Kim, Bong-Jo, Takeuchi, Fumihiko, Zheng, Wei, and Shu, Xiao-Ou

Subjects
Humans, Obesity, Genetic Predisposition to Disease, Waist-Hip Ratio, Sex Factors, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Asian Continental Ancestry Group, Asia, Female, Male, Waist Circumference, Genome-Wide Association Study, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, Clinical Research, Genetics, 2.1 Biological and endogenous factors, Cardiovascular, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

Published
2016

8. Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians

Author

Chen, Peng, Takeuchi, Fumihiko, Lee, Jong-Young, Li, Huaixing, Wu, Jer-Yuarn, Liang, Jun, Long, Jirong, Tabara, Yasuharu, Goodarzi, Mark O, Pereira, Mark A, Kim, Young Jin, Go, Min Jin, Stram, Daniel O, Vithana, Eranga, Khor, Chiea-Chuen, Liu, Jianjun, Liao, Jiemin, Ye, Xingwang, Wang, Yiqin, Lu, Ling, Young, Terri L, Lee, Jeannette, Thai, Ah Chuan, Cheng, Ching-Yu, van Dam, Rob M, Friedlander, Yechiel, Heng, Chew-Kiat, Koh, Woon-Puay, Chen, Chien-Hsiun, Chang, Li-Ching, Pan, Wen-Harn, Qi, Qibin, Isono, Masato, Zheng, Wei, Cai, Qiuyin, Gao, Yutang, Yamamoto, Ken, Ohnaka, Keizo, Takayanagi, Ryoichi, Kita, Yoshikuni, Ueshima, Hirotsugu, Hsiung, Chao A, Cui, Jinrui, Sheu, Wayne H-H, Rotter, Jerome I, Chen, Yii-Der I, Hsu, Chris, Okada, Yukinori, Kubo, Michiaki, Takahashi, Atsushi, Tanaka, Toshihiro, van Rooij, Frank JA, Ganesh, Santhi K, Huang, Jinyan, Huang, Tao, Yuan, Jianmin, Hwang, Joo-Yeon, Group, CHARGE Hematology Working, Gross, Myron D, Assimes, Themistocles L, Miki, Tetsuro, Shu, Xiao-Ou, Qi, Lu, Chen, Yuan-Tson, Lin, Xu, Aung, Tin, Wong, Tien-Yin, Teo, Yik-Ying, Kim, Bong-Jo, Kato, Norihiro, and Tai, E-Shyong

Subjects
Biomedical and Clinical Sciences, Biotechnology, Prevention, Human Genome, Genetics, Minority Health, Diabetes, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adult, Aged, Asian People, Blood Glucose, Cohort Studies, Asia, Eastern, Female, Genetic Heterogeneity, Genetic Loci, Genome-Wide Association Study, Glycated Hemoglobin, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, CHARGE Hematology Working Group, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences
Abstract

Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1c in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (

Published
2014

10. Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis

Author

Ohkuma, Toshiaki, Ninomiya, Toshiharu, Tomiyama, Hirofumi, Kario, Kazuomi, Hoshide, Satoshi, Kita, Yoshikuni, Inoguchi, Toyoshi, Maeda, Yasutaka, Kohara, Katsuhiko, Tabara, Yasuharu, Nakamura, Motoyuki, Ohkubo, Takayoshi, Watada, Hirotaka, Munakata, Masanori, Ohishi, Mitsuru, Ito, Norihisa, Nakamura, Michinari, Shoji, Tetsuo, Vlachopoulos, Charalambos, Aboyans, Victor, and Yamashina, Akira

Published
2018
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13. Association between Dietary Patterns and Serum Low Density Lipoprotein Cholesterol in Japanese Women and Men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

Author

Kitaoka, Kaori, primary, Miura, Katsuyuki, additional, Takashima, Naoyuki, additional, Kadota, Aya, additional, Harada, Akiko, additional, Nakamura, Yasuyuki, additional, Kita, Yoshikuni, additional, Yano, Yuichiro, additional, Tamura, Takashi, additional, Nagayoshi, Mako, additional, Okada, Rieko, additional, Kubo, Yoko, additional, Suzuki, Sadao, additional, Nishiyama, Takeshi, additional, Tanoue, Shiroh, additional, Koriyama, Chihaya, additional, Kuriki, Kiyonori, additional, Arisawa, Kokichi, additional, Katsuura-Kamano, Sakurako, additional, Nishida, Yuichiro, additional, Shimanoe, Chisato, additional, Ozaki, Etsuko, additional, Matsui, Daisuke, additional, Ikezaki, Hiroaki, additional, Otonari, Jun, additional, Oze, Isao, additional, Koyanagi, Yuriko N., additional, Nakamura, Yohko, additional, Kusakabe, Miho, additional, Wakai, Kenji, additional, and Matsuo, Keitaro, additional

Published
2023
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14. Re-evaluation of the associations of egg intake with serum total cholesterol and cause-specific and total mortality in Japanese women

Author

Nakamura, Yasuyuki, Okamura, Tomonori, Kita, Yoshikuni, Okuda, Nagako, Kadota, Aya, Miura, Katsuyuki, and Okayama, Akira

Subjects
Prevention, Risk factors, Methods, Health aspects, Mortality -- Analysis -- Prevention -- Japan, Chronic diseases -- Risk factors, Women's health -- Analysis -- Health aspects -- Methods, Eggs (Food) -- Evaluation -- Analysis -- Health aspects, Cholesterol, Heart attack, Cancer, Retirement benefits, Women
Abstract

Author(s): Yasuyuki Nakamura [sup.1] [sup.2] , Tomonori Okamura [sup.3] , Yoshikuni Kita [sup.4] , Nagako Okuda [sup.5] , Aya Kadota [sup.2] [sup.6] , Katsuyuki Miura [sup.2] [sup.6] , Akira Okayama [...], Background/objective Egg intake was associated with serum total cholesterol adjusted for age (aTCH) and total mortality in women, but not in men, using data from NIPPON DATA (ND) 80 which followed up for 14 years. Re-evaluation of these associations in a different cohort is needed. Subject/methods We analyzed the associations of egg intake with aTCH and cause-specific and total mortality using the ND90 data set with a 15-year follow-up. A nutritional examination was done at the baseline in 1990 using the food-frequency method and by weighed food records. We followed 4686 female participants (ages [greater than or equal to]30 years), with no history of stroke or myocardial infarction (mean age 52.8 years) for 15 years. Results The participants were divided into 5 egg intake groups ( Conclusions Egg intake was associated with cancer and total mortality. Reducing egg intake may have some definitive health benefits in women in Japan, at least.

Published
2018
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16. Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

Author

Ueshima, Hirotsugu, Miura, Katsuyuki, Horie, Minoru, Nakano, Yasutaka, Yamamoto, Takashi, Ogawa, Emiko, Maegawa, Hiroshi, Miyazawa, Itsuko, Murata, Kiyoshi, Mitsunami, Kenichi, Nozaki, Kazuhiko, Shiino, Akihiko, Araki, Isao, Tsuru, Teruhiko, Toyama, Ikuo, Ogita, Hisakazu, Kurita, Souichi, Maeda, Toshinaga, Miyamatsu, Naomi, Kita, Toru, Kimura, Takeshi, Nishio, Yoshihiko, Nakamura, Yasuyuki, Okamura, Tomonori, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Okuda, Nagako, Higashiyama, Aya, Nagasawa, Shinya, Kita, Yoshikuni, Murakami, Yoshitaka, Kadota, Aya, Fujiyoshi, Akira, Takashima, Naoyuki, Kadowaki, Takashi, Kadowaki, Sayaka, Abbott, Robert D., Ohno, Seiko, Arima, Hisatomi, Hisamatsu, Takashi, Miyagawa, Naoko, Torii, Sayuki, Saito, Yoshino, Zaid, Maryam, Suzuki, Sentaro, and Ito, Takahiro

Published
2016
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17. Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population

Author

Ueshima, Hirotsugu, Kadowaki, Takashi, Hisamatsu, Takashi, Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Sekikawa, Akira, Kadota, Aya, Kadowaki, Sayaka, Nakamura, Yasuyuki, Miyagawa, Naoko, Okamura, Tomonori, Kita, Yoshikuni, Takashima, Naoyuki, Kashiwagi, Atsunori, Maegawa, Hiroshi, Horie, Minoru, Yamamoto, Takashi, Kimura, Takeshi, and Kita, Toru

Published
2016
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18. Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of <scp>NIPPON DATA90</scp>

Author

HOANG, Phap Tran Ngoc, KADOTA, Aya, YANO, Yuichiro, HARADA, Akiko, HAYAKAWA, Takehito, OKAMOTO, Shohei, MIYAGAWA, Naoko, KONDO, Keiko, OKUDA, Nagako, KITA, Yoshikuni, OKAYAMA, Akira, FUJITA, Yukihiro, MAEGAWA, Hiroshi, MIURA, Katsuyuki, OKAMURA, Tomonori, UESHIMA, Hirotsugu, and NIPPON DATA90 Research Group

Subjects
Adult, Disability, Endocrinology, Diabetes and Metabolism, General Medicine, Middle Aged, Prediabetic State, Cohort Studies, Japan, Risk Factors, Activities of Daily Living, Diabetes Mellitus, Internal Medicine, Humans, Prospective Studies, Mortality, Prediabetes, Follow-Up Studies
Abstract

Aims/introduction:To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults., Materials and methods:Participants consisted of 1,788 adults aged 45-64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein), at baseline., Results:In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07-1.91 and OR 1.66, 95% CI 1.10-2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16-2.08 and OR 1.77, 95% CI 1.18-2.65, respectively) than individuals with normal glucose tolerance., Conclusions:In middle-aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life.

Published
2022
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19. Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention

Author

Tomiyama, Hirofumi, Ohkuma, Toshiaki, Ninomiya, Toshiharu, Mastumoto, Chisa, Kario, Kazuomi, Hoshide, Satoshi, Kita, Yoshikuni, Inoguchi, Toyoshi, Maeda, Yasutaka, Kohara, Katsuhiko, Tabara, Yasuharu, Nakamura, Motoyuki, Ohkubo, Takayoshi, Watada, Hirotaka, Munakata, Masanori, Ohishi, Mitsuru, Ito, Norihisa, Nakamura, Michinari, Shoji, Tetsuo, Vlachopoulos, Charalambos, Aboyans, Victor, and Yamashina, Akira

Published
2019
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20. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

Author

Nakatochi, Masahiro, Kanai, Masahiro, Nakayama, Akiyoshi, Hishida, Asahi, Kawamura, Yusuke, Ichihara, Sahoko, Akiyama, Masato, Ikezaki, Hiroaki, Furusyo, Norihiro, Shimizu, Seiko, Yamamoto, Ken, Hirata, Makoto, Okada, Rieko, Kawai, Sayo, Kawaguchi, Makoto, Nishida, Yuichiro, Shimanoe, Chisato, Ibusuki, Rie, Takezaki, Toshiro, Nakajima, Mayuko, Takao, Mikiya, Ozaki, Etsuko, Matsui, Daisuke, Nishiyama, Takeshi, Suzuki, Sadao, Takashima, Naoyuki, Kita, Yoshikuni, Endoh, Kaori, Kuriki, Kiyonori, Uemura, Hirokazu, Arisawa, Kokichi, Oze, Isao, Matsuo, Keitaro, Nakamura, Yohko, Mikami, Haruo, Tamura, Takashi, Nakashima, Hiroshi, Nakamura, Takahiro, Kato, Norihiro, Matsuda, Koichi, Murakami, Yoshinori, Matsubara, Tatsuaki, Naito, Mariko, Kubo, Michiaki, Kamatani, Yoichiro, Shinomiya, Nariyoshi, Yokota, Mitsuhiro, Wakai, Kenji, Okada, Yukinori, and Matsuo, Hirotaka

Published
2019
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21. Control of Diabetes Mellitus and Long-Term Prognosis in Stroke Patients: The Shiga Stroke and Heart Attack Registry

Author

Tram, Huynh Thi Hong, Tanaka-Mizuno, Sachiko, Takashima, Naoyuki, Khan, Kawser, Arima, Hisatomi, Kadota, Aya, Fujii, Takako, Shitara, Satoshi, Kitamura, Akihiro, Miyamatsu, Naomi, Kita, Yoshikuni, Urushitani, Makoto, Nakagawa, Yoshihisa, Miura, Katsuyuki, Nozaki, Kazuhiko, Tram, Huynh Thi Hong, Tanaka-Mizuno, Sachiko, Takashima, Naoyuki, Khan, Kawser, Arima, Hisatomi, Kadota, Aya, Fujii, Takako, Shitara, Satoshi, Kitamura, Akihiro, Miyamatsu, Naomi, Kita, Yoshikuni, Urushitani, Makoto, Nakagawa, Yoshihisa, Miura, Katsuyuki, and Nozaki, Kazuhiko

Abstract

BACKGROUND: The relationship between diabetes control status and long-term prognosis after stroke incidence remains unclear. This study aimed to investigate the effect of diabetes status at admission on long-term survival in patients with first-ever stroke. METHODS: A retrospective cohort study was conducted based on the Shiga Stroke and Heart Attack Registry in Japan. Patients were classified according to their diabetes status and glycated hemoglobin (HbA1c) value at hospital admission into the following: (1) free of diabetes (no history of diabetes and HbA1c <6.5%); (2) good control (history of diabetes and HbA1c <7%; free of history and 6.5% ≤HbA1c <7%); and (3) poor control (with or without a history of diabetes and HbA1c ≥7%). Multivariable Cox regression models were used to evaluate the association between diabetes status and long-term survival from stroke onset. Additionally, we also evaluated the association between diabetes status and conditional survival, beginning 29 days after stroke onset. RESULTS: A total of 6, 331 first-ever stroke patients were eligible for this study. Among study patients, the mean (±SD) age was 72.85 ± 13.19 years, and the mean (±SD) follow-up year was 2.76 ± 1.66 years; additionally, 42.09% of patients were women. Among patients with all strokes, considering the free-of-diabetes group as the reference group, the adjusted hazard ratio (95% confidence interval) for mortality was 1.26 (1.10, 1.44) in the good control group and 1.22 (1.05, 1.41) in the poor control group. Among patients with ischemic stroke, the adjusted hazard ratio was 1.24 (1.06, 1.46) in good control group and 1.27 (1.08, 1.50) in poor control group. After excluding patients who died within 28 days, the adjusted hazard ratio for conditional mortality in the poor control group was 1.31 (1.12, 1.54) among all stroke patients and 1.29 (1.08, 1.54) among ischemic stroke patients. No significant associations were observed between diabetic status and long-term mortality

Published
2023

22. Epidemiology of Acute Aortic Dissection in a General Population of 1.4 Million People in Japan ― Shiga Stroke and Heart Attack Registry ―

Author

Higo, Yosuke, primary, Sawayama, Yuichi, additional, Takashima, Naoyuki, additional, Harada, Akiko, additional, Yano, Yuichiro, additional, Yamamoto, Takashi, additional, Shioyama, Wataru, additional, Fujii, Takako, additional, Tanaka-Mizuno, Sachiko, additional, Kita, Yoshikuni, additional, Miura, Katsuyuki, additional, Nozaki, Kazuhiko, additional, Suzuki, Tomoaki, additional, and Nakagawa, Yoshihisa, additional

Published
2023
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23. Relationship of Higher-level Functional Capacity With Long-term Mortality in Japanese Older People: NIPPON DATA90

Author

Nagata, Hideki, primary, Miura, Katsuyuki, additional, Tanaka, Sachiko, additional, Kadota, Aya, additional, Hayakawa, Takehito, additional, Kondo, Keiko, additional, Fujiyoshi, Akira, additional, Takashima, Naoyuki, additional, Kita, Yoshikuni, additional, Okayama, Akira, additional, Okamura, Tomonori, additional, and Ueshima, Hirotsugu, additional

Published
2023
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25. High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population

Author

Hisamatsu, Takashi, Miura, Katsuyuki, Ohkubo, Takayoshi, Yamamoto, Takashi, Fujiyoshi, Akira, Miyagawa, Naoko, Kadota, Aya, Takashima, Naoyuki, Okuda, Nagako, Yoshita, Katsushi, Kita, Yoshikuni, Murakami, Yoshitaka, Nakamura, Yasuyuki, Okamura, Tomonori, Horie, Minoru, Okayama, Akira, and Ueshima, Hirotsugu

Published
2014
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26. Relationship of three different types of low-carbohydrate diet to cardiometabolic risk factors in a Japanese population: the INTERMAP/INTERLIPID Study

Author

Nakamura, Yasuyuki, Ueshima, Hirotsugu, Okuda, Nagako, Miura, Katsuyuki, Kita, Yoshikuni, Miyagawa, Naoko, Yoshita, Katsushi, Nakagawa, Hideaki, Sakata, Kiyomi, Saitoh, Shigeyuki, Okamura, Tomonori, Okayama, Akira, Choudhry, Sohel R., Rodriguez, Beatriz, Masaki, Kamal H., Chan, Queenie, Elliott, Paul, and Stamler, Jeremiah

Published
2016
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27. Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study

Author

Saita, Kosuke, primary, Sumitani, Masahiko, additional, Nishizawa, Daisuke, additional, Tamura, Takashi, additional, Ikeda, Kazutaka, additional, Wakai, Kenji, additional, Sudo, Yoshika, additional, Abe, Hiroaki, additional, Otonari, Jun, additional, Ikezaki, Hiroaki, additional, Takeuchi, Kenji, additional, Hishida, Asahi, additional, Tanaka, Keitaro, additional, Shimanoe, Chisato, additional, Takezaki, Toshiro, additional, Ibusuki, Rie, additional, Oze, Isao, additional, Ito, Hidemi, additional, Ozaki, Etsuko, additional, Matsui, Daisuke, additional, Nakamura, Yohko, additional, Kusakabe, Miho, additional, Suzuki, Sadao, additional, Nakagawa-Senda, Hiroko, additional, Arisawa, Kokichi, additional, Katsuura-Kamano, Sakurako, additional, Kuriki, Kiyonori, additional, Kita, Yoshikuni, additional, Nakamura, Yasuyuki, additional, Momozawa, Yukihide, additional, and Uchida, Kanji, additional

Published
2022
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28. Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese : The Japan Multi-Institutional Collaborative Cohort Study

Author

Iwase, Madoka, Matsuo, Keitaro, Nakatochi, Masahiro, Oze, Isao, Ito, Hidemi, Koyanagi, Yuriko, Ugai, Tomotaka, Kasugai, Yumiko, Hishida, Asahi, Takeuchi, Kenji, Okada, Rieko, Kubo, Yoko, Shimanoe, Chisato, Tanaka, Keitaro, Ikezaki, Hiroaki, Murata, Masayuki, Takezaki, Toshiro, Nishimoto, Daisaku, Kuriyama, Nagato, Ozaki, Etsuko, Suzuki, Sadao, Watanabe, Miki, Mikami, Haruo, Nakamura, Yohko, Uemura, Hirokazu, Katsuura-Kamano, Sakurako, Kuriki, Kiyonori, Kita, Yoshikuni, Takashima, Naoyuki, Nagino, Masato, Momozawa, Yukihide, Kubo, Michiaki, and Wakai, Kenji

Subjects
obesity, nutritional and metabolic diseases, body mass index, polymorphisms, genome wide association study
Abstract

Background: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities. Methods: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models. Results: We found a significant association (P < 0.05/282 = 1.77 × 10−4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained, even after additional adjustment for dietary energy intake. Conclusions: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.

Published
2021

29. Control of Diabetes Mellitus and Long-Term Prognosis in Stroke Patients: The Shiga Stroke and Heart Attack Registry

Author

Tram, Huynh Thi Hong, primary, Tanaka-Mizuno, Sachiko, additional, Takashima, Naoyuki, additional, Khan, Kawser, additional, Arima, Hisatomi, additional, Kadota, Aya, additional, Fujii, Takako, additional, Shitara, Satoshi, additional, Kitamura, Akihiro, additional, Miyamatsu, Naomi, additional, Kita, Yoshikuni, additional, Urushitani, Makoto, additional, Nakagawa, Yoshihisa, additional, Miura, Katsuyuki, additional, and Nozaki, Kazuhiko, additional

Published
2022
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30. Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population

Author

Fujii, Ryosuke, primary, Hishida, Asahi, additional, Nakatochi, Masahiro, additional, Tsuboi, Yoshiki, additional, Suzuki, Koji, additional, Kondo, Takaaki, additional, Ikezaki, Hiroaki, additional, Hara, Megumi, additional, Okada, Rieko, additional, Tamura, Takashi, additional, Shimoshikiryo, Ippei, additional, Suzuki, Sadao, additional, Koyama, Teruhide, additional, Kuriki, Kiyonori, additional, Takashima, Naoyuki, additional, Arisawa, Kokichi, additional, Momozawa, Yukihide, additional, Kubo, Michiaki, additional, Takeuchi, Kenji, additional, Wakai, Kenji, additional, Matsuo, Keitaro, additional, Tanaka, Keitaro, additional, Miura, Katsuyuki, additional, Kita, Yoshikuni, additional, Takezaki, Toshiro, additional, Nagase, Hiroki, additional, Mikami, Haruo, additional, Uehara, Ritei, additional, and Narimatsu, Hiroto, additional

Published
2022
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31. Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90

Author

Hirata, Aya, primary, Okamura, Tomonori, additional, Hirata, Takumi, additional, Sugiyama, Daisuke, additional, Ohkubo, Takayoshi, additional, Okuda, Nagako, additional, Kita, Yoshikuni, additional, Hayakawa, Takehito, additional, Kadota, Aya, additional, Kondo, Keiko, additional, Miura, Katsuyuki, additional, Okayama, Akira, additional, and Ueshima, Hirotsugu, additional

Published
2022
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34. Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults Case-control study

Author

Saita, Kosuke, Sumitani, Masahiko, Nishizawa, Daisuke, Tamura, Takashi, Ikeda, Kazutaka, Wakai, Kenji, Sudo, Yoshika, Abe, Hiroaki, Otonari, Jun, Ikezaki, Hiroaki, Takeuchi, Kenji, Hishida, Asahi, Tanaka, Keitaro, Shimanoe, Chisato, Takezaki, Toshiro, Ibusuki, Rie, Oze, Isao, Ito, Hidemi, Ozaki, Etsuko, Matsui, Daisuke, Nakamura, Yohko, Kusakabe, Miho, Suzuki, Sadao, Nakagawa-Senda, Hiroko, Arisawa, Kokichi, Katsuura-Kamano, Sakurako, Kuriki, Kiyonori, Kita, Yoshikuni, Nakamura, Yasuyuki, Momozawa, Yukihide, Uchida, Kanji, Saita, Kosuke, Sumitani, Masahiko, Nishizawa, Daisuke, Tamura, Takashi, Ikeda, Kazutaka, Wakai, Kenji, Sudo, Yoshika, Abe, Hiroaki, Otonari, Jun, Ikezaki, Hiroaki, Takeuchi, Kenji, Hishida, Asahi, Tanaka, Keitaro, Shimanoe, Chisato, Takezaki, Toshiro, Ibusuki, Rie, Oze, Isao, Ito, Hidemi, Ozaki, Etsuko, Matsui, Daisuke, Nakamura, Yohko, Kusakabe, Miho, Suzuki, Sadao, Nakagawa-Senda, Hiroko, Arisawa, Kokichi, Katsuura-Kamano, Sakurako, Kuriki, Kiyonori, Kita, Yoshikuni, Nakamura, Yasuyuki, Momozawa, Yukihide, and Uchida, Kanji

Abstract

Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)—located on the gene encoding for pleiotrophin on chromosome 7—that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.

Published
2022

39. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score

Author

Hachiya, Tsuyoshi, Kamatani, Yoichiro, Takahashi, Atsushi, Hata, Jun, Furukawa, Ryohei, Shiwa, Yuh, Yamaji, Taiki, Hara, Megumi, Tanno, Kozo, Ohmomo, Hideki, Ono, Kanako, Takashima, Naoyuki, Matsuda, Koichi, Wakai, Kenji, Sawada, Norie, Iwasaki, Motoki, Yamagishi, Kazumasa, Ago, Tetsuro, Ninomiya, Toshiharu, Fukushima, Akimune, Hozawa, Atsushi, Minegishi, Naoko, Satoh, Mamoru, Endo, Ryujin, Sasaki, Makoto, Sakata, Kiyomi, Kobayashi, Seiichiro, Ogasawara, Kuniaki, Nakamura, Motoyuki, Hitomi, Jiro, Kita, Yoshikuni, Tanaka, Keitaro, Iso, Hiroyasu, Kitazono, Takanari, Kubo, Michiaki, Tanaka, Hideo, Tsugane, Shoichiro, Kiyohara, Yutaka, Yamamoto, Masayuki, Sobue, Kenji, and Shimizu, Atsushi

Published
2017
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45. Incidence and In-Hospital Mortality of Acute Myocardial Infarction: A Report from a Population-Based Registry in Japan

Author

Sawayama, Yuichi, primary, Takashima, Naoyuki, additional, Harada, Akiko, additional, Yano, Yuichiro, additional, Yamamoto, Takashi, additional, Higo, Yosuke, additional, Shioyama, Wataru, additional, Fujii, Takako, additional, Tanaka-Mizuno, Sachiko, additional, Kita, Yoshikuni, additional, Miura, Katsuyuki, additional, Nozaki, Kazuhiko, additional, Suzuki, Tomoaki, additional, and Nakagawa, Yoshihisa, additional

Published
2022
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47. Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

Author

Takeuchi, Kenji, primary, Naito, Mariko, additional, Kawai, Sayo, additional, Tsukamoto, Mineko, additional, Kadomatsu, Yuka, additional, Kubo, Yoko, additional, Okada, Rieko, additional, Nagayoshi, Mako, additional, Tamura, Takashi, additional, Hishida, Asahi, additional, Nakatochi, Masahiro, additional, Sasakabe, Tae, additional, Hashimoto, Shuji, additional, Eguchi, Hidetaka, additional, Momozawa, Yukihide, additional, Ikezaki, Hiroaki, additional, Murata, Masayuki, additional, Furusyo, Norihiro, additional, Tanaka, Keitaro, additional, Hara, Megumi, additional, Nishida, Yuichiro, additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Oze, Isao, additional, Mikami, Haruo, additional, Nakamura, Yohko, additional, Kusakabe, Miho, additional, Takezaki, Toshiro, additional, Ibusuki, Rie, additional, Shimoshikiryo, Ippei, additional, Suzuki, Sadao, additional, Nishiyama, Takeshi, additional, Watanabe, Miki, additional, Koyama, Teruhide, additional, Ozaki, Etsuko, additional, Watanabe, Isao, additional, Kuriki, Kiyonori, additional, Kita, Yoshikuni, additional, Ueshima, Hirotsugu, additional, Matsui, Kenji, additional, Arisawa, Kokichi, additional, Uemura, Hirokazu, additional, Katsuura-Kamano, Sakurako, additional, Nakamura, Sho, additional, Narimatsu, Hiroto, additional, Hamajima, Nobuyuki, additional, Tanaka, Hideo, additional, and Wakai, Kenji, additional

Published
2021
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48. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Sumi, Masaki, Hisamatsu, Takashi, Fujiyoshi , Akira, Kadota, Aya, Miyagawa, Naoko, Kondo, Keiko, Kadowaki, Sayaka, Suzuki , Sentaro, Torii, Sayuki, Zaid Maryam, Sato, Atsushi, Arima, Hisatomi, Terada, Tomohiro, Miura, Katsuyuki, Ueshima , Hirotsugu, Horie Minoru, Nakano Yasutaka, Yamamoto Takashi, Hayashi Hideki, Ogawa Emiko, Maegawa Hiroshi, Miyazawa Itsuko, Murata Kiyoshi, Mitsunami Kenichi, Nozaki Kazuhiko, Tooyama Ikuo, Shiino Akihiko, Tsuru Teruhiko, Ogita Hisakazu, Shimizu Akio, Miyamatsu Naomi, Kita Toru, Kimura Takeshi, Nishio Yoshihiko, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Edmundowicz Daniel, Ohkubo Takayoshi, Hozawa Atsushi, Murakami Yoshitaka, Okuda Nagako, Arima Hisatomi, Kita Yoshikuni, Hisamatsu Takashi, Higashiyama Aya, Nagasawa Shinya, Azuma Koichiro, Yanagita Masahiko, Abbott Robert D., Kadota Aya, Ohno Seiko, Fujiyoshi Akira, Takashima Naoyuki, Kadowaki Takashi, Kadowaki Sayaka, Miyagawa Naoko, Kondo Keiko, Torii Sayuki, Saito Yoshino, Suzuki Sentaro, Ito Takahiro, Satoh Atsushi, and Yamazoe Masahiro

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Epidemiology, alcohol consumption, Population, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, visceral adipose tissue, Adverse effect, education, Nutrition, Aged, lcsh:R5-920, education.field_of_study, Anthropometry, business.industry, anthropometric obesity indice, Confounding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, fat deposition, Obesity, Subcutaneous Fat, Abdominal, Epidemiologic Studies, Cross-Sectional Studies, Population Surveillance, Original Article, lcsh:Medicine (General), Tomography, X-Ray Computed, business, Body mass index
Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend

Published
2019
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49. Predictors of lower limb fractures in general Japanese: NIPPON DATA90

Author

SAITO, Yoshino, MIURA, Katsuyuki, ARIMA, Hisatomi, HAYAKAWA, Takehito, TAKASHIMA, Naoyuki, KITA, Yoshikuni, OKUDA, Nagako, FUJIYOSHI, Akira, IWAHORI, Toshiyuki, MIYAGAWA, Naoko, KONDO, Keiko, TORII, Sayuki, KADOTA, Aya, OHKUBO, Takayoshi, OKAYAMA, Akira, OKAMURA, Tomonori, UESHIMA, Hirotsugu, and NIPPON DATA90 Research Group

Subjects
Male, Asia, Databases, Factual, Epidemiology, Physiology, Science, Body Mass Index, Geographical Locations, Fractures, Bone, Japan, Risk Factors, Medicine and Health Sciences, Humans, Public and Occupational Health, Prospective Studies, Femur, Musculoskeletal System, Skeleton, Aged, Proportional Hazards Models, Nutrition, Multidisciplinary, Incidence, Traumatic Injury Risk Factors, Body Weight, Age Factors, Biology and Life Sciences, Middle Aged, Nutrition Surveys, Diet, Lower Extremity, Physiological Parameters, Food, Body Limbs, Medical Risk Factors, People and Places, Medicine, Female, Anatomy, Femoral Fractures, Research Article
Abstract

Objective:This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population., Methods:NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures)., Results:The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow-up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age., Conclusions:Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women.

Published
2021

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