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Stemphiliosis of onion is a relatively new disease in Ukraine. The disease appears in the form of oblong spots on the leaves and causes premature leaf death. The aim of the work is to propose means of protection for control of onion stemphyliosis based on the study of the pathocenosis species composition, biophenology of the disease agent of onion stemphyliosis and determination of the fungicides efficiency. Field studies were carried out on plantings of onion variety Banco in the farm AF "Petrodolynske" Odessa district, Odessa region of Ukraine in 2019-2021. We identified the causative agents of onion stemphyliosis - Stemphylium vesicarium (Wallr.) Simm, Stemphylium botryosum Wallr, Stemphylium herbarum Simm. which had different frequency of occurrence in the samples. The preparations with the following active substances were found to control the disease most effectively under field conditions: fluopyram (200 g/l) + tebuconazole (200 g/l) and fluoxastrobin (100 g/l) + prothioconazole (100 g/l). [ABSTRACT FROM AUTHOR]