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3. World guidelines for falls prevention and management for older adults: a global initiative

Author

Montero-Odasso, Manuel, van der Velde, Nathalie, Martin, Finbarr C, Petrovic, Mirko, Tan, Maw Pin, Ryg, Jesper, Aguilar-Navarro, Sara, Alexander, Neil B, Becker, Clemens, Blain, Hubert, Bourke, Robbie, Cameron, Ian D, Camicioli, Richard, Clemson, Lindy, Close, Jacqueline, Delbaere, Kim, Duan, Leilei, Duque, Gustavo, Dyer, Suzanne M, Freiberger, Ellen, Ganz, David A, Gómez, Fernando, Hausdorff, Jeffrey M, Hogan, David B, Hunter, Susan MW, Jauregui, Jose R, Kamkar, Nellie, Kenny, Rose-Anne, Lamb, Sarah E, Latham, Nancy K, Lipsitz, Lewis A, Liu-Ambrose, Teresa, Logan, Pip, Lord, Stephen R, Mallet, Louise, Marsh, David, Milisen, Koen, Moctezuma-Gallegos, Rogelio, Morris, Meg E, Nieuwboer, Alice, Perracini, Monica R, Pieruccini-Faria, Frederico, Pighills, Alison, Said, Catherine, Sejdic, Ervin, Sherrington, Catherine, Skelton, Dawn A, Dsouza, Sabestina, Speechley, Mark, Stark, Susan, Todd, Chris, Troen, Bruce R, van der Cammen, Tischa, Verghese, Joe, Vlaeyen, Ellen, Watt, Jennifer A, Masud, Tahir, Singh, Devinder Kaur Ajit, Aguilar-Navarro, Sara G, Caona, Edgar Aguilera, Allen, Natalie, Anweiller, Cedric, Avila-Funes, Alberto, Santos, Renato Barbosa, Batchelor, Francis, Beauchamp, Marla, Birimoglu, Canan, Bohlke, Kayla, Bourke, Robert, Bouzòn, Christina Alonzo, Bridenbaugh, Stephanie, Buendia, Patricio Gabriel, Cameron, Ian, Canning, Colleen, Cano-Gutierrez, Carlos Alberto, Carbajal, Juan Carlos, de Abreu, Daniela Cristina Carvalho, Casas-Herrero, Alvaro, Ceriani, Alejandro, Cesari, Matteo, Chiari, Lorenzo, Alemǻn, Luis Manuel Cornejo, Dawson, Rik, Doody, Paul, Dyer, Suzanne, Ellmers, Toby, Fairhall, Nicola, Ferruci, Luigi, and Frith, James

Subjects
Biomedical and Clinical Sciences, Health Services and Systems, Public Health, Health Sciences, Clinical Sciences, Aging, Prevention, Clinical Research, Patient Safety, Physical Injury - Accidents and Adverse Effects, Health and social care services research, 8.1 Organisation and delivery of services, 7.1 Individual care needs, Management of diseases and conditions, Good Health and Well Being, Aged, Caregivers, Humans, Independent Living, Quality of Life, Risk Assessment, falls, injury, aged, guidelines, recommendations, clinical practice, world, global, consensus, older people, Task Force on Global Guidelines for Falls in Older Adults, Public Health and Health Services, Psychology, Geriatrics, Clinical sciences, Health services and systems, Applied and developmental psychology
Abstract

Backgroundfalls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs. Current guidelines are inconsistent, with no up-to-date, globally applicable ones present.Objectivesto create a set of evidence- and expert consensus-based falls prevention and management recommendations applicable to older adults for use by healthcare and other professionals that consider: (i) a person-centred approach that includes the perspectives of older adults with lived experience, caregivers and other stakeholders; (ii) gaps in previous guidelines; (iii) recent developments in e-health and (iv) implementation across locations with limited access to resources such as low- and middle-income countries.Methodsa steering committee and a worldwide multidisciplinary group of experts and stakeholders, including older adults, were assembled. Geriatrics and gerontological societies were represented. Using a modified Delphi process, recommendations from 11 topic-specific working groups (WGs), 10 ad-hoc WGs and a WG dealing with the perspectives of older adults were reviewed and refined. The final recommendations were determined by voting.Recommendationsall older adults should be advised on falls prevention and physical activity. Opportunistic case finding for falls risk is recommended for community-dwelling older adults. Those considered at high risk should be offered a comprehensive multifactorial falls risk assessment with a view to co-design and implement personalised multidomain interventions. Other recommendations cover details of assessment and intervention components and combinations, and recommendations for specific settings and populations.Conclusionsthe core set of recommendations provided will require flexible implementation strategies that consider both local context and resources.

Published
2022

12. Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks

Author

Abel, Laurent, Alcover, Andres, Aschard, Hugues, Bousso, Philippe, Bourke, Nollaig, Brodin, Petter, Bruhns, Pierre, Cerf-Bensussan, Nadine, Cumano, Ana, D’Enfert, Christophe, Deriano, Ludovic, Dillies, Marie-Agnès, Di Santo, James, Eberl, Gérard, Enninga, Jost, Fellay, Jacques, Gomperts-Boneca, Ivo, Hasan, Milena, Hedestam, Gunilla Karlsson, Hercberg, Serge, Ingersoll, Molly A., Lantz, Olivier, Kenny, Rose Anne, Ménager, Mickaël, Mouquet, Hugo, O'Farrelly, Cliona, Patin, Etienne, Pellegrini, Sandra, Rausell, Antonio, Rieux-Laucat, Frédéric, Rogge, Lars, Fontes, Magnus, Sakuntabhai, Anavaj, Schwartz, Olivier, Schwikowski, Benno, Shorte, Spencer, Tangy, Frédéric, Toubert, Antoine, Touvier, Mathilde, Ungeheuer, Marie-Noëlle, Zimmer, Christophe, Albert, Matthew L., Duffy, Darragh, Quintana-Murci, Lluis, Villain, Etienne, Chanson, Aurélie, Mainka, Malwina, Kampschulte, Nadja, Le Faouder, Pauline, Bertrand-Michel, Justine, Brandolini-Bunlon, Marion, Charbit, Bruno, Musvosvi, Munyaradzi, Bilek, Nicole, Scriba, Thomas J., Schebb, Nils Helge, and Gladine, Cécile

Published
2023
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14. Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis

Author

McCrory, Cathal, McLoughlin, Sinead, Layte, Richard, NiCheallaigh, Cliona, O’Halloran, Aisling M., Barros, Henrique, Berkman, Lisa F., Bochud, Murielle, M. Crimmins, Eileen, T. Farrell, Meagan, Fraga, Silvia, Grundy, Emily, Kelly-Irving, Michelle, Petrovic, Dusan, Seeman, Teresa, Stringhini, Silvia, Vollenveider, Peter, and Kenny, Rose Anne

Published
2023
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16. Can Artificial Intelligence Enhance Syncope Management?: A JACC: Advances Multidisciplinary Collaborative Statement

Author

Statz, Giselle M., Evans, Aron Z., Johnston, Samuel L., Adhaduk, Mehul, Mudireddy, Avinash R., Sonka, Milan, Lee, Sangil, Barsotti, E. John, Ricci, Fabrizio, Dipaola, Franca, Johansson, Madeleine, Sheldon, Robert S., Thiruganasambandamoorthy, Venkatesh, Kenny, Rose-Anne, Bullis, Tyler C., Pasupula, Deepak K., Van Heukelom, Jon, Gebska, Milena A., and Olshansky, Brian

Published
2023
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17. Risk Factors for Incident Dementia Among Older Cubans

Author

Peeters, Geeske, Sanchez, Arianna Almirall, Guerra, Jorge Llibre, Lawlor, Brian, Kenny, Rose Anne, Yaffe, Kristine, and Rodriguez, Juan Llibre

Subjects
Health Services and Systems, Public Health, Health Sciences, Dementia, Aging, Neurosciences, Acquired Cognitive Impairment, Alzheimer's Disease, Prevention, Neurodegenerative, Clinical Research, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Behavioral and Social Science, Nutrition, Aetiology, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, 2.4 Surveillance and distribution, Prevention of disease and conditions, and promotion of well-being, Neurological, Stroke, Aged, Cohort Studies, Hispanic or Latino, Humans, Longitudinal Studies, Risk Factors, dementia, risk profile, lifestyle, older adults, epidemiology, Public Health and Health Services, Health services and systems, Public health
Abstract

Introduction: Little is known about risk factors of dementia in Latin American countries. We aimed to identify socio-demographic, health and lifestyle risk factors of incident dementia in Cuban older adults. Methods: Data were from 1,846 participants in the Cuban cohort of the 10/66 Dementia Research Group. Participants completed questionnaires, health examinations, and cognitive tests at baseline (2003-2006) and 4.5 years later (2007-2010). Associations between risk factors (baseline) and incident dementia (follow-up) were examined using logistic regression. Results: Just over 9% of participants developed dementia. Overall, older age and low physical activity were associated with incident dementia. In those 65-74 years of age, depression, stroke and low physical activity were associated with incident dementia. In those ≥75 years of age, low physical activity, never eating fish, and smoking were associated with incident dementia. Conclusions: Modifiable lifestyle factors play an important role in developing dementia in Cuban older adults. This knowledge opens up opportunities for preventive strategies.

Published
2020

26. A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Author

Cappozzo, Andrea, McCrory, Cathal, Robinson, Oliver, Freni Sterrantino, Anna, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Iacoviello, Licia, Ricceri, Fulvio, Sieri, Sabina, Chiodini, Paolo, McKay, Gareth J., McKnight, Amy Jayne, Kee, Frank, Young, Ian S., McGuinness, Bernadette, Crimmins, Eileen M., Arpawong, Thalida Em, Kenny, Rose Anne, O’Halloran, Aisling, Polidoro, Silvia, Solinas, Giuliana, Vineis, Paolo, Ieva, Francesca, and Fiorito, Giovanni

Published
2022
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36. Frailty on the island of Ireland: evidence from the NICOLA and TILDA studies.

Author

McKelvie, Mische-Jasmine, Cruise, Sharon, Ward, Mark, Romero-Ortuno, Roman, Kee, Frank, Kenny, Rose Anne, O'Reilly, Dermot, and O'Halloran, Aisling M

Subjects
MORTALITY risk factors, SECONDARY analysis, FRAIL elderly, DESCRIPTIVE statistics, DISEASE prevalence, LONGITUDINAL method, GERIATRIC assessment, AGING, CONFIDENCE intervals, COMPARATIVE studies
Abstract

Background Aimed to compare the prevalence, characteristics, and associated mortality risk of frailty in Northern Ireland (NI) and the Republic of Ireland (ROI). Methods Secondary analysis of the first wave of two nationally representative cohorts, the Northern Ireland Cohort for the Longitudinal Study of Ageing or NICOLA study (N  = 8504) and the Irish Longitudinal Study on Ageing or TILDA study (N  = 8504). Frailty was assessed using a harmonized accumulation deficits frailty index (FI) containing 30 items. FI scores classified individuals as non-frail (<0.10), pre-frail (0.10–0.24) and frail (≥0.25). Linkage to respective administrative data sources provided mortality information with a follow-up time of 8 years. Results The prevalence of frailty was considerably higher in NI compared with the ROI (29.0% compared with 15.0%), though pre-frailty was slightly lower (35.8% and 37.3%, respectively). Age, female sex, and lower socio-economic status were consistently associated with a higher likelihood of both pre-frailty and frailty. In the pooled analysis, both frailty and pre-frailty were higher in NI (RR = 2.68, 95% CIs 2.45, 2.94 and RR = 1.30, 95% CIs 1.21, 1.40, respectively). Frailty was associated with an increased mortality risk in both cohorts, even after full adjustment for all other characteristics, being marginally higher in TILDA than in NICOLA (HR = 2.43, 95% CIs 2.03, 2.91 vs. HR = 2.31, 95% CIs 1.90, 2.79). Conclusions Frailty is a major public health concern for both jurisdictions. Further research and monitoring are required to elucidate why there is a higher prevalence in NI and to identify factors in early life that may be driving these differences. [ABSTRACT FROM AUTHOR]

Published
2024
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