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1. Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study)

Author

Yilmaz, Dilek, Ekemen Keles, Yildiz, Emiroglu, Melike, Duramaz, Burcu Bursal, Ugur, Cuneyt, Aldemir Kocabas, Bilge, Celik, Talyan, Ozdemir, Halil, Bayturan, Semra, Turel, Ozden, Erdeniz, Emine Hafize, Cakici, Ozlem, Cakmak Taskin, Esra, Erbas, İrem Ceren, Genceli, Mustafa, Sari, Emine Ergul, Caymaz, Canan, Kizil, Mahmut Can, Sutcu, Murat, Demirbuga, Asuman, Alkan, Gulsum, Bagcı, Zafer, Timurtas Dayar, Gulperi, Ozkan, Esra Akyuz, Tekin Yilmaz, Ayse, Akca, Mehtap, Yesil, Edanur, Kara, Soner Sertan, Akturk, Hacer, Yasar, Belma, Umit, Zuhal, Uygun, Hatice, Erdem, Nurettin, Buyukcam, Ayse, Karadag Oncel, Eda, Tuter Oz, Sadiye Kubra, Cetin, Hafize Selma, Anil, Ayse Berna, Yilmaz, Resul, Zengin, Neslihan, Uzuner, Selcuk, Albayrak, Hatice, Borakay, Ozgur, Topal, Sevgi, Arslan, Gazi, Yazar, Abdullah, Ozer, Arife, Kendirli, Tanil, Kara, Emine Manolya, Demirkol, Demet, Battal, Fatih, Kosker, Muhammet, Metin Akcan, Ozge, Kihtir, Hasan Serdar, Gul, Doruk, Zararci, Kazim, Alakaya, Mehmet, Kula, Nilgun, Celik, Elif, Petmezci, Ercument, Evren, Gultac, Kara Aksay, Ahu, Konca, Capan, Sert, Ahmet, Arslan, Derya, Bornaun, Helen, Tekeli, Onur, Bal, Alkan, Sahin, Irfan Oguz, Demir, Selcan, Sap, Fatih, Akyol, Mehmet Bedir, Tanidir, Ibrahim Cansaran, Donmez, Yasemin Nuran, Ucar, Tayfun, Coban, Senay, Arga, Gul, Hancerli Torun, Selda, Karpuz, Derya, Celik, Serkan Fazli, Varan, Celal, Elmali, Ferhan, Oncel, Selim, Belet, Nursen, Hatipoglu, Nevin, Dalgic Karabulut, Nazan, Turgut, Mehmet, Somer, Ayper, Kuyucu, Necdet, Dinleyici, Ener Cagri, Ciftci, Ergin, and Kara, Ates

Published
2023
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3. Characteristics of continuous venovenous hemodiafiltration in the acute treatment of inherited metabolic disorders

Author

Eminoglu, Fatma Tuba, Öncül, Ümmühan, Kahveci, Fevzi, Okulu, Emel, Kraja, Elvis, Köse, Engin, and Kendirli, Tanil

Subjects
Metabolism, Inborn errors of -- Care and treatment, Health
Abstract

Background Continuous kidney replacement therapies (CKRT) have been reported to be an effective approach to removing toxic metabolites in inborn errors of metabolism (IEM). The present study evaluates efficiency and complications of CKRT in children with IEM. Methods Patients diagnosed with IEM who underwent CKRT in pediatric and neonatal intensive care units were analyzed. CKRT were initiated in patients with persistently high blood ammonia levels ([greater than or equal to] 500 [mu]mol/L), blood ammonia levels > 250 [mu]mol/L in the presence of moderate encephalopathy, high blood leucine levels ([greater than or equal to] 1500 [mu]mol/L), and blood leucine levels < 1500 [mu]mol/L in the presence of deteriorating neurological status or persistent metabolic acidosis. Results Of 22 patients enrolled, nine (40.9%) Maple syrup urine disease (MSUD), eight (36.4%) urea cycle disorders (UCD), and five (22.7%) organic acidemias (OA). Median age was 72.3 [9.9-1040.8] days. In total, 28 dialysis sessions were analyzed [16 (57.1%) continuous venovenous hemodialysis, and 12 (42.9%) continuous venovenous hemodiafiltration]. A significant decrease was noted in leucine levels (from 1608.4 ± 885.3 to 314.6 ± 109.9 [micro]mol/L) of patients with MSUD, while ammonia levels were significantly decreased in patients with UCD and OA (from 1279.9 ± 612.1 to 85.1 ± 21.6 [micro]mol/L). The most frequent complications of CKRT were thrombocytopenia (60.7%), hypotension (53.6%), and hypocalcemia (42.9%). Median age of patients with hypotension treated with vasoactive medications was significantly lower than median age of those with normal blood pressure. Conclusion CKRT is a reliable approach for effective and rapid removal of toxic metabolites in children with IEM, and CKRT modalities can be safely used and are well-tolerated in infants., Author(s): Fatma Tuba Eminoglu [sup.1] , Ümmühan Öncül [sup.1] , Fevzi Kahveci [sup.2] , Emel Okulu [sup.3] , Elvis Kraja [sup.3] , Engin Köse [sup.1] , Tanil Kendirli [sup.2] Author [...]

Published
2022
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5. Paediatric critical COVID-19 and mortality in a multinational prospective cohort

Author

Nofziger, Ryan, Ambati, Shashikanth, Kendirli, Tanil, Sanders, Ronald, Polikoff, Lee, Whelan, Siobhan, Camporesi, Anna, Francoeur, Conall, Castro, Francisca, Beltrán, Claudia, Pardo, Rosalba, Vega, Gonzalo, Yunge, Mauricio, Acevedo, Lorena, Ardila, Ivan Jose, Aranguiz, Diego, Dallefeld, Samantha, Alvarez-Olmos, MarthaI, Fernandez-Sarmiento, Jaime, Figueroa-Vargas, Arieth, Valencia-Benavides, Maribel, Roa, Juan David, Lasso-Palomino, Rubén, Franceschi, Alessia, Venthur, Carina, Gonzalez-Dambrauskas, Sebastian, Ampuero, Camila, Paco-Barral, Jhovana E., Tasayco-Muñoz, Jaime, Domínguez-Rojas, Jesús, Rafael-Patricio, Francisca, Pellegrini, Solana, Zuazaga, Marcela, Brusca, Silvana, Viera, Marisa, Aguilera-Avendano, Vladmir Ivan, Alejandro, F., Martínez, L., Thelma, E., Terán, M., Coronado-Lujan, Mariela, Castro-Mancilla, Fabiola, Diaz-Rubio, Franco, Cinquegrana, Karina, Sandoval, Alicia, Gonzalez, Andrea, Zamora, Marta, Lopez-Alarcon, Yurika, Slöcker-Barrio, María, Urbano-Villaescusa, Javier, Camacho, Humberto, Mazzillo, Liliana, Giraldo, Beatriz, Suarez, Pitas, Cespedes-Lesczinsky, Miguel, Castillo, Jorge Omar, Fabris, Juan Pablo, Paladino, Carolina, Sanabria, Silvia, Urena-Chavarría, Erika, Yock-Corrales, Adriana, Quispe, Gaudi, Munaico-Abanto, Manuel, Colombo, Miriam, Blanco, Ana Carola, Pineres-Olave, Byron Enrique, Carvajal-Veas, Ricardo, Correa, Patricia, Garcia-De-Jesus, Ricardo, Ferre, Arani, Pietroboni, Pietro, Mauricio-Cantillano, Edwin, Banegas-Pineda, Linda, Casson-Rodriguez, Nils, Cavagnaro, Agustin, Wegner, Adriana, Zemanate, Eliana, Beltran-Zuñiga, Emilce, Suarez, Maria Alejandra, Quiñonez, Deyanira, Valero, Leonardo, Repetur, Alejandra, Castellani, Pablo, Bordogna, Adriana, De-la-Hoz-Pastor, Alfredo, Obando-Belalcazar, Evelyn, Prout, Andrew, Jabornisky, Roberto, Wen, Andy, Coates, Bria, Watson, Christopher, Mack, Elizabeth, Hong, Jahee, Karsies, Todd, Pon, Steven, Dapul, Heda, Shein, Steven, Kangin, Murat, Vasquez-Hoyos, Pablo, Gertz, Shira, Ducharme-Crevier, Laurence, Harwayne-Gidansky, Ilana, Fonseca-Flores, Marisol, Nunez-Enriquez, Juan Carlos, Leon-Villanueva, Armando, Maria, Ledys, Muisyo, Teddy, Spaeder, Michael, Cantillano, Edwin Mauricio, Dominguez-Rojas, Jesus, Gurbanov, Anar, Mazzillo-Vega, Liliana, and Shein, Steven L.

Published
2022
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6. Prospective cohort study of incidence and risk factors for Catheter-associated Urinary Tract Infections in 212 Intensive Care Units of nine Middle Eastern countries

Author

Jin, Zhilin, Yin, Ruijie, Brown, Eric Christopher, Shukla, Bhavarth, Lee, Brandon Hochahn, Abdulaziz-Alkhawaja, Safaa, Magray, Tahera Anwar, Agha, Hala Mounir, El-Sisi, Amal, El-Kholy, Amani Ali, Bayani, Victor, Daboor, Mohammad Abdellatif, Al-Ruzzieh, Majeda Afeef, Guclu, Ertugrul, Horoz, Ozden Ozgur, Kendirli, Tanil, Koksal, Iftihar, Memish, Ziad A, Olmez-Gazioglu, Esra, Dursun, Oguz, Kara, Tugce Tural, Eroglu, Ahmet, Havan, Merve, Deniz, Suna Secil Ozturk, Aktas, Gizem, Yildizdas, Dincer, Okulu, Emel, Kostekci, Yasemin Ezgi, Omar, Abeer Aly, and Rosenthal, Victor Daniel

Published
2023

15. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series

Author

Thorburn, Kentigern, Nunes, Marta, Chawana, Richard, Madhi, Shabir A., Vittuci, Anna C., Bassat, Quique, Bardají, Azucena, Goka, Edward, Roglić, Srđan, Paes, Bosco, Elliott, LouAnn, Oshitani, Hitoshi, Lupisan, Socorro, Gentile, Angela, Lucion, María Florencia, Spaeder, Michael C., Butt, Warwick, Thompson, Jenny, Mejias, Asuncion, Ramilo, Octavio, Fasce, Rodrigo A., Werner, Marta, Hijano, Diego R., Allison, Kim J., Pires, Márcia Rosane, de-Paris, Fernanda, Chakhunashvili, Giorgi, Karseladze, Irakli, Otieno, Grieven P., Nokes, D. James, Scheuerman, Oded, Prais, Dario, Amad, Mohammed Al, Serouri, Abdul Wahed Al, Ali, Asad, Yousafzai, Mohammad Tahir, Bruno, Alfredo, de Mora, Domenica, Ojeda, Jenny, Dbaibo, Ghassan, Hanna-Wakim, Rima, Papaevangelou, Vassiliki, Kartisouni, Elpiniki, Cohen, Cheryl, Walaza, Sibongile, Linssen, Rosalie S., Chi, Hsin, Eşki, Aykut, Demir, Esen, Saha, Senjuti, Saha, Samir K, Sochet, Anthony A., Teppa-Sanchez, Beatriz E., Ravindranath, Thyyar M., Baird, J. Scott, Morris, Shaun K., Wong, Waison, Breiman, Robert F., Gurley, Emily S., Arifeen, Shams El, Assefa, Nega, Scott, J. Anthony G., Onyango, Dickens, Kotloff, Karen L., Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu U., Jambai, Amara, Kendirli, Tanil, Botan, Edin, Rubio, Franco Díaz, Serra, Alberto, Martinez, Luis, Pedroso, Luis, Menta, Soledad, Pardo, Rosalba, Donoso, Alejandro, Mahmood, Syed Faisal, Khan, Naveera, Löwensteyn, Yvette N, Nair, Harish, Nunes, Marta C, van Roessel, Ichelle, Vernooij, Femke S, Willemsen, Joukje, Bont, Louis J, and Mazur, Natalie I

Published
2021
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17. Evaluation of Patients Diagnosed with Acute Flaccid Paralysis Followed and Treated in Pediatric İntensive Care: A Multi-Center Study

Author

BOTAN, EDIN, primary, BOYRAZ, MERVE, additional, YÜCE, SERVET, additional, GÜN, EMRAH, additional, ÖZEN, HASAN, additional, HAVAN, MERVE, additional, AŞIK, AYŞE, additional, GURBANOV, ANAR, additional, KARADAĞLI, EDA EŞE, additional, BOTAN, EMİNE ULU, additional, TORUN, ŞEYMA ERDEM, additional, KÖKER, ALPER, additional, YAVUZ, SİNAN, additional, BOYDAĞ, KÜBRA, additional, DUYU, MUHTEREM, additional, HOROZ, ÖZDEN ÖZGÜR, additional, EKİNCİ, FARUK, additional, DURSUN, OĞUZ, additional, YILDIZDAŞ, RIZA DİNÇER, additional, and KENDİRLİ, TANIL, additional

Published
2024
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19. Evaluation of nutritional status in pediatric intensive care unit patients: the results of a multicenter, prospective study in Turkey

Author

Misirlioglu, Merve, primary, Yildizdas, Dincer, additional, Ekinci, Faruk, additional, Ozgur Horoz, Ozden, additional, Tumgor, Gokhan, additional, Yontem, Ahmet, additional, Talay, Mehmet Nur, additional, Kangin, Murat, additional, Tufan, Erennur, additional, Kesici, Selman, additional, Yener, Nazik, additional, Kinik Kaya, Hatice Elif, additional, Havan, Merve, additional, Tunc, Ali, additional, Akçay, Nihal, additional, Sevketoglu, Esra, additional, Durak, Fatih, additional, Ozel Dogruoz, Aysenur, additional, Ozcan, Serhan, additional, Perk, Oktay, additional, Duyu, Muhterem, additional, Boyraz, Merve, additional, Uysal Yazici, Mutlu, additional, Ozturk, Zeynelabidin, additional, Çeleğen, Mehmet, additional, Bukulmez, Aysegul, additional, Kacmaz, Ebru, additional, Cagri Dinleyici, Ener, additional, Dursun, Oguz, additional, Koker, Alper, additional, Bayraktar, Suleyman, additional, Talip Petmezci, Mey, additional, Nabaliyeva, Aygul, additional, Agin, Hasan, additional, Hepduman, Pinar, additional, Akkuzu, Emine, additional, Kendirli, Tanil, additional, Ozen, Hasan, additional, Topal, Sevgi, additional, Ödek, Çağlar, additional, Ozkale, Murat, additional, Ozkale, Yasemin, additional, Atay, Gürkan, additional, Erdoğan, Seher, additional, Konca, Capan, additional, Yapici, Guler, additional, Arslan, Gazi, additional, Besci, Tolga, additional, Yilmaz, Resul, additional, Gumus, Meltem, additional, Oto, Arzu, additional, Dalkiran, Tahir, additional, Mercan, Mehmet, additional, Çoban, Yasemin, additional, Ipek, Sevcan, additional, Gungor, Sukru, additional, Arslankoylu, Ali Ertug, additional, Alakaya, Mehmet, additional, Sari, Ferhat, additional, Yucel, Aylin, additional, and Yazar, Abdullah, additional

Published
2023
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20. Analysis of Intestinal and Nasopharyngeal Microbiota of Children with Meningococcemia in Pediatric Intensive Care Unit: INMACS-PICU Study

Author

Bozan, Gurkan, primary, Pérez-Brocal, Vicente, additional, Aslan, Kaan, additional, Kiral, Eylem, additional, Sevketoglu, Esra, additional, Uysal Yazici, Mutlu, additional, Azapagasi, Ebru, additional, Kendirli, Tanil, additional, Emeksiz, Serhat, additional, Dursun, Oguz, additional, Yildizdas, Dincer, additional, Anil, Ayse Berna, additional, Akcay, Nihal, additional, Kihtir, Hasan Serdar, additional, Havan, Merve, additional, Ulgen Tekerek, Nazan, additional, Ekinci, Faruk, additional, Kilic, Omer, additional, Moya, Andres, additional, and Dinleyici, Ener Cagri, additional

Published
2023
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21. Daily Practice of Mechanical Ventilation and Weaning in Turkish PICUs: A Multicenter Prospective Survey

Author

Tekgüç, Hakan, Can, Fulya Kamit, Şik, Güntülü, Demirkol, Demet, Özel, Deniz, Yaman, Ayhan, Işgüder, Rana, Yildiztaş, Dinçer, Yener, Nazik A, Öztürk, Nilufer Y., Karaarslan, Utku, Erdoğan, Seher, Yazci, Pinar, Dinleyici, Ener C., Dalkiran, Tahir, Şevketoğlu, Esra, Anil, Ayse Berna, Çitak, Agop, Aygün, Fatih, Kendirli, Tanil, Ağin, Hasan, Horoz, Ozden O., Paksu, Şükrü, İnceköy, Feyza G., Davutoğlu, Mehmet, Köroğlu, Tolga, Boşnak, Mehmet, Karapinar, Bülent, and Dursun, Oğuz

Published
2020
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23. Analysis of intestinal and nasopharyngeal microbiota of children with meningococcemia in pediatric intensive care unit: INMACS-PICU study

Author

Eskisehir Technical University, Bozan, Gurkan, Pérez-Brocal, Vicente, Aslan, Kaan, Kiral, Eylem, Sevketoglu, Esra, Yazici, Mutlu Uysal, Azapagasi, Ebru, Kendirli, Tanil, Emeksiz, Serhat, Dursun, Oguz, Yildizdas, Dincer, Anil, Ayse Berna, Akcay, Nihal, Kihtir, Hasan Serdar, Havan, Merve, Ulgen Tekerek, Nazan, Ekinci, Faruk, Kilic, Omer, Moya, Andrés, Dinleyici, Ener Cagri, Eskisehir Technical University, Bozan, Gurkan, Pérez-Brocal, Vicente, Aslan, Kaan, Kiral, Eylem, Sevketoglu, Esra, Yazici, Mutlu Uysal, Azapagasi, Ebru, Kendirli, Tanil, Emeksiz, Serhat, Dursun, Oguz, Yildizdas, Dincer, Anil, Ayse Berna, Akcay, Nihal, Kihtir, Hasan Serdar, Havan, Merve, Ulgen Tekerek, Nazan, Ekinci, Faruk, Kilic, Omer, Moya, Andrés, and Dinleyici, Ener Cagri

Abstract

Microbiota composition might play a role in the pathophysiology and course of sepsis, and understanding its dynamics is of clinical interest. Invasive meningococcal disease (IMD) is an important cause of community-acquired serious infection, and there is no information regarding microbiota composition in children with meningococcemia. In this study, we aimed to evaluate the intestinal and nasopharyngeal microbiota composition of children with IMD., [Materials and Methods]: In this prospective, multi-center study, 10 children with meningococcemia and 10 age-matched healthy controls were included. Nasopharyngeal and fecal samples were obtained at admission to the intensive care unit and on the tenth day of their hospital stay. The V3 and V4 regions of the 16S rRNA gene were amplified following the 16S Metagenomic Sequencing Library Preparation., [Results]: Regarding the alpha diversity on the day of admission and on the tenth day at the PICU, the Shannon index was significantly lower in the IMD group compared to the control group (p = 0.002 at admission and p = 0.001, on the tenth day of PICU). A statistical difference in the stool samples was found between the IMD group at Day 0 vs. the controls in the results of the Bray–Curtis and Jaccard analyses (p = 0.005 and p = 0.001, respectively). There were differences in the intestinal microbiota composition between the children with IMD at admission and Day 10 and the healthy controls. Regarding the nasopharyngeal microbiota analysis, in the children with IMD at admission, at the genus level, Neisseria was significantly more abundant compared to the healthy children (p < 0.001). In the children with IMD at Day 10, genera Moraxella and Neisseria were decreased compared to the healthy children. In the children with IMD on Day 0, for paired samples, Moraxella, Neisseria, and Haemophilus were significantly more abundant compared to the children with IMD at Day 10. In the children with IMD at Day 10, the Moraxella and Neisseria genera were decreased, and 20 different genera were more abundant compared to Day 0., [Conclusions]: We first found alterations in the intestinal and nasopharyngeal microbiota composition in the children with IMD. The infection itself or the other care interventions also caused changes to the microbiota composition during the follow-up period. Understanding the interaction of microbiota with pathogens, e.g., N. meningitidis, could give us the opportunity to understand the disease’s dynamics.

Published
2023

27. Antidepressant Poisoning Trends in Pediatric Intensive Care

Author

Gurbanov, Anar, primary, Kandemir, Hande, additional, Gurbanova, Lala, additional, Gün, Emrah, additional, Botan, Edin, additional, Balaban, Burak, additional, Kahveci, Fevzi, additional, Özen, Hasan, additional, Uçmak, Hacer, additional, Özdemir, İhsan, additional, Havan, Merve, additional, Tekin, Deniz, additional, and Kendirli, Tanil, additional

Published
2023
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29. Mortality risk factors among critically ill children with MIS-C in PICUs: a multicenter study

Author

Celegen, Mehmet, Kılınc, Mehmet Arda, Alakaya, Mehmet, Yukselmıs, Ufuk, Yener, Nazik, Yıldızdas, Dincer, Telhan, Leyla, Gırgın, Feyza İnceköy, Kıhtır, Hasan Serdar, Oto, Arzu, Zengın, Neslihan, Dalkıran, Tahir, Yetımakman, Ayse Filiz, Havan, Merve, Duman, Murat, Altug, Umit, Bayraktar, Suleyman, Kangın, Murat, Arslan, Gazi, Ozcan, Serhan, Bırbılen, Ahmet Ziya, Duyu, Muhterem, Ozkaya, Pınar Yazıcı, Varol, Fatih, Sandal, Ozlem, Atay, Gurkan, KENDİRLİ, TANIL, AYGÜN, FATİH, KESİCİ, SELMAN, Akçay, Nihal, Inamlık, Aysegul, Sık, Guntulu, Başar, Evic Zeynep, Mercan, Mehmet, Bal, Alkan, Kılıc, Nevin, Ongun, Ebru Atike, Ozturk, Makbule Nilufer, Ekıncı, Faruk, Udurgucu, Muhammed, Arslankoylu, Ali Ertug, Kutlu, Nurettin Onur, Bukulmez, Aysegul, Özsoylu, Serkan, Anıl, Ayşe Berna, Ozdemır, Göktug, Emeksız, Serhat, Durak, Fatih, Boyraz, Merve, Arı, Hatice Feray, Sahın, Ebru, Seven, Pınar, Erdogan, Seher, Gun, Emrah, Durak, Cansu, Katlan, Banu, Sevketoglu, Esra, Annayev, Agageldi, Bıngol, Ibrahim, Cıtak, Agop, Yaman, Ayhan, Odek, Caglar, Alacakır, Nuri, Yazar, Abdullah, Kocaoglu, Celebi, Topal, Sevgi, Ozkale, Murat, Sarı, Ferhat, Battal, Fatih, Dursun, Adem, Celık, Taylan, Ozkale, Yasemin, Kılıc, Ahmet Osman, Harmanogulları, Sezer, Luleyap, Doga, Yener, Gülcin Otar, Talay, Mehmet Nur, and Sık G., Inamlık A., Akçay N., KESİCİ S., AYGÜN F., KENDİRLİ T., Atay G., Sandal O., Varol F., Ozkaya P. Y., et al.

Subjects
Internal Medicine Sciences, Klinik Tıp, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Sağlık Bilimleri, Clinical Medicine (MED), Tıp, Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases, PEDIATRICS, Health Sciences, Pediatrics, Perinatology and Child Health, Medicine, Klinik Tıp (MED), PEDİATRİ, Pediatri, Perinatoloji ve Çocuk Sağlığı
Abstract

Background: This study evaluated of clinical characteristics, outcomes, and mortality risk factors of a severe multisystem inflammatory syndrome in children admitted to a the pediatric intensive care unit. Methods: A retrospective multicenter cohort study was conducted between March 2020 and April 2021 at 41 PICUs in Turkey. The study population comprised 322 children diagnosed with multisystem inflammatory syndrome. Results: The organ systems most commonly involved were the cardiovascular and hematological systems. Intravenous immunoglobulin was used in 294 (91.3%) patients and corticosteroids in 266 (82.6%). Seventy-five (23.3%) children received therapeutic plasma exchange treatment. Patients with a longer duration of the PICU stay had more frequent respiratory, hematological, or renal involvement, and also had higher D-dimer, CK-MB, and procalcitonin levels. A total of 16 patients died, with mortality higher in patients with renal, respiratory, or neurological involvement, with severe cardiac impairment or shock. The non-surviving group also had higher leukocyte counts, lactate and ferritin levels, and a need for mechanical ventilation. Conclusions: In cases of MIS-C, high levels of D-dimer and CK-MB are associated with a longer duration of PICU stay. Non-survival correlates with elevated leukocyte counts and lactate and ferritin levels. We were unable to show any positive effect of therapeutic plasma exchange therapy on mortality. Impact: MIS-C is a life-threatening condition.Patients need to be followed up in the intensive care unit.Early detection of factors associated with mortality can improve outcomes.Determining the factors associated with mortality and length of stay will help clinicians in patient management.High D-dimer and CK-MB levels were associated with longer PICU stay, and higher leukocyte counts, ferritin and lactate levels, and mechanical ventilation were associated with mortality in MIS-C patients.We were unable to show any positive effect of therapeutic plasma exchange therapy on mortality.

Published
2023

31. Mortality Risk Factors Among Critically Ill Children With Acute COVID-19 in PICUs: A Multicenter Study From Turkish Pediatric Critical COVID-19 and MIS-C Study Group

Author

Yükselmiş, Ufuk, Altuğ, Ümüt, Yazici, MUTLU, Duman, Murat, Oğur, Mustafa, Menentoğlu, Mehmet Emin, Erdoğan, Seher, Talay, Mehmet Nur, Özkale, Yasemin, Ongun, Ebru Atike, Bülbül, Beyhan, Soydan, Ekin, Birbilen, Ahmet Ziya, Ersayoğlu, İrem, Arslan, Gazi, Utku, Hatice Sinav, Boyraz, Merve, Albayrak, Hatice, Akin, Fatih, Girgin, Feyza İnceköy, Çetin, Benhur Şirvan, Ekinci, Faruk, Gayretli Aydin, Zeynep Gökçe, Bayrakçi, Benan, Çitak, Agop, Perk, Oktay, Şahin, Ebru, Kiral, Eylem, Bozdemir, Şefika Elmas, Ersoy, Murat, Gurbanov, Anar, Aygün, Fatih, Sofuoğlu, Ayşe İrem, Yetimakman, Ayşe Filiz, Yaman, Ayhan, Kamit, Fulya, Alaçakir, Nuri, Çoban, Yasemin, Atay, Gürkan, Kangin, Murat, Özkale, Murat, Çeleğen, Mehmet, Barlas, Ülkem Kocoğlu, Ödek, Çağlar, Sandal, Özlem Saraç, Aslan, Nagehan, Durak, Fatih, Özkaya, Pinar Yazici, Besci, Tolga, Akkuzu, EMİNE, Öztürk, Zeynelabidin, Topal, Sevgi, Yesilbaş, Osman, Yildizdaş, Dinçer, Akyildiz, Başak, Öztürk, Makbule Nilüfer Yalindağ, Yazar, Abdullah, Yener, Nazik, Petmezci, Mey Talip, Bayraktar, Süleyman, Oto, Arzu, Duyu, Muhterem, Kutlu, Nurettin Onur, Akcay, Nihal, Kihtir, Hasan Serdar, Durak, Cansu, Kendirli, Tanil, Havan, Merve, Kockuzu, Esra, Bozan, Gurkan, Sevketoglu, Esra, Varol, Fatih, Uyar, Emel, Özçifçi, Gökçen, Şik, Güntülü, and Terzi, Kivanç

Subjects
Microbiology (medical), Male, Adolescent, Turkey, Critical Illness, COVID-19, Infant, Intensive Care Units, Pediatric, Systemic Inflammatory Response Syndrome, Infectious Diseases, Risk Factors, Child, Preschool, Pediatrics, Perinatology and Child Health, Humans, Female, Child, Retrospective Studies
Abstract

Background: During the coronavirus disease 2019 (COVID-19) pandemic, the world has a large number of reported COVID-19 cases and deaths. Information on characteristics and mortality rate of pediatric intensive care unit (PICU) cases with COVID-19 remains limited. This study aims to identify the risk factors for mortality related to COVID-19 in children admitted to PICU. Methods: A retrospective multicenter cohort study was conducted between March 2020 and April 2021 at 44 PICUs in Turkey. Children who were 1 month-18-year of age with confirmed COVID-19 admitted to PICU were included in the study. Children with multisystem inflammatory syndrome and asymptomatic for COVID-19 were excluded. Results: Of 335 patients with COVID-19, the median age was 6.8 years (IQR: 1.2-14) and 180 (53.7 %) were male, 215 (64.2 %) had at least one comorbidity. Age and gender were not related to mortality. Among 335 patients, 166 (49.5%) received mechanical ventilation, 17 (5.1%) received renal replacement therapy and 44 (13.1 %) died. Children with medical complexity, congenital heart disease, immunosuppression and malignancy had significantly higher mortality. On multivariable logistic regression analysis, organ failure index [odds ratio (OR): 2.1, 95 confidence interval (CI): 1.55-2.85], and having congenital heart disease (OR: 2.65, 95 CI: 1.03-6.80), were associated with mortality. Conclusions: This study presents detailed data on clinical characteristics and outcomes of patients with COVID-19 admitted to PICU in the first pandemic year in Turkey. Our study shows that having congenital heart disease is associated with mortality. In addition, the high organ failure score in follow-up predict mortality.

Published
2022

34. SARS-CoV-2 infection showing signs of cerebral sinus vein thrombosis in the infantile period

Author

Arga, Gul, primary, Erkol, Hatice Gul, additional, Taskin, Esra Cakmak, additional, Konca, Hatice Kubra, additional, Tas, Ilayda, additional, Erdogan, Burcu Ozge, additional, Ozdemir, Halil, additional, Cakmaklı, Hasan Fatih, additional, Kahveci, Fevzi, additional, Demir, Berrin, additional, Kendirli, Tanil, additional, Fitoz, Suat, additional, and Ciftci, Ergin, additional

Published
2022
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37. Global respiratory syncytial virus–related infant community deaths

Author

Mazur, Natalie I., Löwensteyn, Yvette N., Willemsen, Joukje E., Gill, Christopher J., Forman, Leah, Mwananyanda, Lawrence M., Blau, Dianna M., Breiman, Robert F., Madhi, Shabir A., Mahtab, Sana, Gurley, Emily S., El Arifeen, Shams, Assefa, Nega, Scott, J. Anthony G., Onyango, Dickens, Tippet Barr, Beth A., Kotloff, Karen L., Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu, Jambai, Amara, Bassat, Quique, Thamthitiwat, Somsak, Gentile, Angela, Lucion, Maria Florencia, Pires, Márcia Rosane, de-Paris, Fernanda, Gordon, Aubree, Sánchez, José Félix, Lucero, Marilla G., Lupisan, Socorro P., Gessner, Bradford D., Tall, Haoua, Halasa, Natasha, Khuri-Bulos, Najwa, Nokes, D. James, Munywoki, Patrick K., Otieno, Grieven P., O’Brien, Katherine L., Oshitani, Katherine L., da Costa Oliveira, Maria Tereza, de Freitas Lázaro Emediato, Carla Cecília, Ali, Asad, Aamir, Uzma Bashir, Noyola, Daniel E., Cohen, Cheryl, Moyes, Jocelyn, Giamberardino, Heloisa Ihle Garcia, Webler, Jane Melissa, de Matos Bezerra, Patricia Gomes, Bezerra Duarte, Maria do Carmo Menezes, Chu, Helen Y., Das, Rashmi Ranjan, Weber, Martin W., Homaira, Nusrat, Jaffe, Adam, Sturm-Ramirez, Katharine M., Su, Wei, Yuan, Chiang Chun, Chaves, Sandra, Emukule, Gideon O., de Andrade Nishioka, Sergio, de Carvalho, Felipe Cotrim, Gökçe, Şule, Raboni, Sonia M., Hawkes, Michael, Messaoudi, Melina, Bryant, Juliet, Dbaibo, Ghassan S., Hanna-Wakim, Rima, Sampath Jayaweera, J. A. A., Stolyarov, Kirill, Suntarattiwong, Piyarat, Mussá, Tufária, Bruno, Alfredo, de Mora, Domenica, Wanlapakorn, Nasamon, de Xie, Zheng, Ai, Junhong, Ojeda, Jenny, Zamora, Lida, Obodai, Evangeline, Odoom, John Kofi, Ismail, Maha Talaat, Buchwald, Andrea, O’Callaghan-Gordo, Cristina, Fernandez-Sarmiento, Jaime, Obando-Belalcazar, Evelyn, Dhole, Tapan, Verma, Sheetal, Eşki, Aykut, Ozturk Kartal, G., Al Amad, Mohammed, Al Serouri, Abdul Wahed, FunChan, Yoke, Sam, Jamal I-Ching, Jarovsky, Daniel, da Silva, Daniella Gregória Bomfim Prado, Perales, José Gareca, Toh, Teck-Hock, Yit, Jeffrey Lee Soon, Kendirli, Tanil, Gun, Emrah, Sagna, Tani, Diagbouga, Serge, Chowdhury, Fahmida, Islam, Md Ariful, Venter, Marietjie, Visser, Adele, Pham, Minh-Hong, Vásquez-Hoyos, Pablo, González-Dambrauskas, Sebastián, Rubio, Franco Díaz, Karsies, Todd, Zemanate, Eliana, Izquierdo, Ledys, Palomino, Rubén Lasso, Pardo-Carrero, Rosalba, Grigolli-Cesar, Reginna, Menta, Soledad, Monteverde, Nicolás, Duyu, Muhterem, Saha, Senjuti, Saha, Samir K., Kelly, Matthew, Echavarria, Marcela, Tran, Tuan, Borgi, Aida, Ayari, Ahmed, Caballero, Mauricio T., Polack, Fernando P., Omer, Saad, Kazi, Abdul Momin, Simões, Eric A. F., Satav, Ashish, Bont, Louis J., and HASH(0x5651c98a3e48)

Subjects
childhood mortality, Pediatrics, Younger age, respiratory syncytial virus, data analysis, Supplement Articles, Infant Death, child death, newborn, Respiratory system, Child, register, Pediatric Death, infant mortality, Hospitalization, Infectious Diseases, female, AcademicSubjects/MED00290, Microbiology (medical), medicine.medical_specialty, RJ, Developing country, respiratory syncytial virus vaccine, Respiratory Syncytial Virus Infections, Virus, Article, Age Distribution, male, Lower respiratory tract infection, medicine, Human respiratory syncytial virus, Respiratory Syncytial Virus Vaccines, Humans, human, respiratory syncytial virus infection, nonhuman, business.industry, developing country, Infant, Newborn, Infant, medicine.disease, major clinical study, newborn death, Infant mortality, clinical feature, Respiratory Syncytial Virus, Human, lower respiratory tract infection, community death, Neonatal death, business, community hospital, in-hospital mortality, RC
Abstract

Background: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths, Bill and Melinda Gates Foundation, BMGF: OPP1148988.8; Johnson and Johnson, J&J; Merck; Roche; AbbVie, This publication is based on research funded in part by the Bill & Melinda Gates Foundation (grant number OPP1148988.8). ES reports grants from Bill and Melinda Gates Foundation, during the conduct of the study; grants, personal fees and non-financial support from Astra Zeneca Inc, grants, personal fees and non-financial support from Merck & Co., grants, personal fees and non-financial support from Regeneron Inc, grants, personal fees and non-financial support from Pfizer Inc, personal fees, non-financial support and other from Abbvie Inc, personal fees from Alere Inc, grants, personal fees and non-financial support from Roche Inc, other from GSK Inc, grants from Johnson and Johnson, grants and nonfinancial support from Novavax Inc, outside the submitted work; FP reports grants and personal fees from JANSSEN, grants and personal fees from NOVAVAX, INC, personal fees from BAVARIAN NORDIC A/S, personal fees from PFIZER, personal fees from SANOFI, personal fees from REGENERON, personal fees from MERCK, outside the submitted work.

Published
2022

38. Paediatric critical COVID-19 and mortality in a multinational prospective cohort

Author

Gonzalez-Dambrauskas, Sebastian, primary, Vasquez-Hoyos, Pablo, additional, Camporesi, Anna, additional, Cantillano, Edwin Mauricio, additional, Dallefeld, Samantha, additional, Dominguez-Rojas, Jesus, additional, Francoeur, Conall, additional, Gurbanov, Anar, additional, Mazzillo-Vega, Liliana, additional, Shein, Steven L., additional, Yock-Corrales, Adriana, additional, Karsies, Todd, additional, Nofziger, Ryan, additional, Ambati, Shashikanth, additional, Kendirli, Tanil, additional, Sanders, Ronald, additional, Polikoff, Lee, additional, Whelan, Siobhan, additional, Castro, Francisca, additional, Beltrán, Claudia, additional, Pardo, Rosalba, additional, Vega, Gonzalo, additional, Yunge, Mauricio, additional, Acevedo, Lorena, additional, Ardila, Ivan Jose, additional, Aranguiz, Diego, additional, Alvarez-Olmos, MarthaI, additional, Fernandez-Sarmiento, Jaime, additional, Figueroa-Vargas, Arieth, additional, Valencia-Benavides, Maribel, additional, Roa, Juan David, additional, Lasso-Palomino, Rubén, additional, Franceschi, Alessia, additional, Venthur, Carina, additional, Gonzalez-Dambrauskas, Sebastian, additional, Ampuero, Camila, additional, Paco-Barral, Jhovana E., additional, Tasayco-Muñoz, Jaime, additional, Domínguez-Rojas, Jesús, additional, Rafael-Patricio, Francisca, additional, Pellegrini, Solana, additional, Zuazaga, Marcela, additional, Brusca, Silvana, additional, Viera, Marisa, additional, Aguilera-Avendano, Vladmir Ivan, additional, Alejandro, F., additional, Martínez, L., additional, Thelma, E., additional, Terán, M., additional, Coronado-Lujan, Mariela, additional, Castro-Mancilla, Fabiola, additional, Diaz-Rubio, Franco, additional, Cinquegrana, Karina, additional, Sandoval, Alicia, additional, Gonzalez, Andrea, additional, Zamora, Marta, additional, Lopez-Alarcon, Yurika, additional, Slöcker-Barrio, María, additional, Urbano-Villaescusa, Javier, additional, Camacho, Humberto, additional, Mazzillo, Liliana, additional, Giraldo, Beatriz, additional, Suarez, Pitas, additional, Cespedes-Lesczinsky, Miguel, additional, Castillo, Jorge Omar, additional, Fabris, Juan Pablo, additional, Paladino, Carolina, additional, Sanabria, Silvia, additional, Urena-Chavarría, Erika, additional, Quispe, Gaudi, additional, Munaico-Abanto, Manuel, additional, Colombo, Miriam, additional, Blanco, Ana Carola, additional, Pineres-Olave, Byron Enrique, additional, Carvajal-Veas, Ricardo, additional, Correa, Patricia, additional, Garcia-De-Jesus, Ricardo, additional, Ferre, Arani, additional, Pietroboni, Pietro, additional, Mauricio-Cantillano, Edwin, additional, Banegas-Pineda, Linda, additional, Casson-Rodriguez, Nils, additional, Cavagnaro, Agustin, additional, Wegner, Adriana, additional, Zemanate, Eliana, additional, Beltran-Zuñiga, Emilce, additional, Suarez, Maria Alejandra, additional, Quiñonez, Deyanira, additional, Valero, Leonardo, additional, Repetur, Alejandra, additional, Castellani, Pablo, additional, Bordogna, Adriana, additional, De-la-Hoz-Pastor, Alfredo, additional, Obando-Belalcazar, Evelyn, additional, Prout, Andrew, additional, Jabornisky, Roberto, additional, Wen, Andy, additional, Coates, Bria, additional, Watson, Christopher, additional, Mack, Elizabeth, additional, Hong, Jahee, additional, Pon, Steven, additional, Dapul, Heda, additional, Shein, Steven, additional, Kangin, Murat, additional, Gertz, Shira, additional, Ducharme-Crevier, Laurence, additional, Harwayne-Gidansky, Ilana, additional, Fonseca-Flores, Marisol, additional, Nunez-Enriquez, Juan Carlos, additional, Leon-Villanueva, Armando, additional, Maria, Ledys, additional, Muisyo, Teddy, additional, and Spaeder, Michael, additional

Published
2022
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39. Increased Severe Cases and New-Onset Type 1 Diabetes Among Children Presenting With Diabetic Ketoacidosis During First Year of COVID-19 Pandemic in Turkey

Author

Kiral, Eylem, primary, Kirel, Birgul, additional, Havan, Merve, additional, Keskin, Mehmet, additional, Karaoglan, Murat, additional, Yildirim, Ahmet, additional, Kangin, Murat, additional, Talay, Mehmet Nur, additional, Urun, Tuba, additional, Altug, Umit, additional, Kesici, Selman, additional, Tufan, Erennur, additional, Kacmaz, Ebru, additional, Bozan, Gurkan, additional, Azapagasi, Ebru, additional, Uysal Yazici, Mutlu, additional, Ozturk, Zeynelabidin, additional, Yesilbas, Osman, additional, Karaguzel, Gulay, additional, Kaya, Gulay, additional, Barlas, Ulkem, additional, Duyu, Muhterem, additional, Boyraz, Merve, additional, Sevketoglu, Esra, additional, Akcay, Nihal, additional, Hancili, Suna, additional, Guven, Ayla, additional, Dursun, Oǧuz, additional, Ulgen Tekerek, Nazan, additional, Ozcifci, Gokçen, additional, Yazici, Pinar, additional, Turanli, Eda, additional, Kendirli, Tanil, additional, Kahveci, Fevzi, additional, Yetimakman, Ayse Filiz, additional, Citak, Agop, additional, Şik, Guntulu, additional, Bingol, Ibrahim, additional, Aygun, Fatih, additional, Durak, Cansu, additional, Yilmaz, Resul, additional, Bugrul, Fuat, additional, Sari, Yusuf, additional, Tekguç, Hakan, additional, Albayrak, Hatice, additional, Yener, Nazik, additional, Agin, Hasan, additional, Soydan, Ekin, additional, Yildizdas, Dincer, additional, Dilek, Semine Ozdemir, additional, Yalindag, Nilufer, additional, Incekoy-Girgin, Feyza, additional, Alacakir, Nuri, additional, Tutunculer, Filiz, additional, Arslanaoglu, Mehmet Ozgur, additional, Aydin, Can, additional, Bilgin, Muzaffer, additional, Simsek, Enver, additional, and Dinleyici, Ener Cagri, additional

Published
2022
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41. Covid-19 transmission and clinical features in pediatric intensive care health care workers

Author

Botan, Edin, Uyar, Emel, Ozturk, Zeynelabidin, Sevketoglu, Esra, Sari, Yusuf, Dursun, Oguz, Sincar, Sahin, Duyu, Muhterem, Oto, Arzu, Celegen, Mehmet, Ozciftci, Gokcen, Havan, Merve, Ozturk, Makbule Nilufer, Agin, Hasan, Yener, Nazik, Yaman, Ayhan, Gun, Emrah, Yilmaz, Merve, Simsek, Naile, Ozdemir, Halil, Yildizdas, Dincer, Kendirli, Tanil, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yaman, Ayhan, BOTAN E., Uyar E., Ozturk Z., Sevketoglu E., Sari Y., DURSUN O., Sincar S., Duyu M., Oto A., Celegen M., et al., and Çeleğen, Mehmet

Subjects
Internal Medicine Sciences, Klinik Tıp, SARS-CoV-2, COVID-19, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Health Care Worker, Sağlık Bilimleri, Pediatrics, Clinical Medicine (MED), Tıp, Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases, Pediatric Intensive Care Unit, Health Sciences, Pediatrics, Perinatology and Child Health, Health care worker, Medicine, Pediatric intensive care unit, Klinik Tıp (MED), PEDİATRİ, Covid-19, Children
Abstract

Objective: This study aims to investigate modes of transmission and clinical features of coronavirus disease 2019 in healthcare workers in pediatric intensive care units. Materials and Methods: This multicenter descriptive study was conducted between March and November 2020. Patient demographics, clinical characteristics, origin of coronavirus disease 2019, treatment modalities, and loss of workdays were recorded. Results: Seven hundred and sixty-eight healthcare workers from 16 pediatric intensive care units were enrolled and 114 (14.8%) healthcare workers with a mean age of 29.7 +/- 6.7 years became coronavirus disease 2019 patients. Seventy-six (66.7%) patients were female. Approximately half (54.3%) of the patients were physicians, 34.2% were nurses, and 11.4% were ancillary staff. Transmission was deemed to occur through patient contact in 54.3% of the patients. Comorbid illness was present 10.5% of the patients. Transmission occurred during endotracheal intubation in 21%, cardiopulmonary resuscitation in 9.6%, and non-invasive ventilation in 12.2% of patients, while transmission was a result of multiple possible procedures in 43.8%. Intensive care admission was needed for 13.1% of the patients. Five patients needed oxygen by cannula, 7 needed oxygen with a non-rebreathing mask, 5 needed high-flow nasal cannula support, 5 needed non-invasive ventilation, and 3 needed invasive mechanical ventilation. Fortunately, no infected healthcare workers died. Conclusion: Coronavirus disease 2019 in healthcare workers is a significant problem in pediatric intensive care units. Transmission seems to occur particularly frequently during patient care procedures such as intubation, ventilation and aerosol therapy, which highlights the importance of proper use of full sets of personal protective equipment during all procedures during care of coronavirus disease 2019 patients. WOS:000744060100015

Published
2022

42. Comparison of pre-PICU and per-PICU interventions, clinical features and neurologic outcomes of motor vehicle collision trauma and other mechanisms of trauma in children

Author

BOTAN, EDİN, KENDİRLİ, TANIL, ATEŞ, UFUK, ERGÜN, ERGUN, KAHILOĞULLARI, GÖKMEN, GÜN, EMRAH, AZAPAĞASI, EBRU, PERK, OKTAY, HAVAN, MERVE, AKYÜZLÜER GÜNEŞ, MERVE SETENAY, and ÖZCAN, SERHAN

Subjects
Motor Vehicles, Anesthesiology and Pain Medicine, Multiple Trauma, Accidents, Traffic, Emergency Medicine, Humans, Surgery, Child, Intensive Care Units, Pediatric, Retrospective Studies
Abstract

BACKGROUND: Motor vehicle collisions (MVCs) are the number one cause of death in the pediatric age group. The aim of this study was to determine the differences between MVCs and other trauma mechanisms (OTMs) in patients who were followed up at a pediatric intensive care unit (PICU). METHODS: Data were retrospectively collected for pediatric trauma patients hospitalized at a third level PICU between 2014 and 2018. Patients have been divided into two groups as MVC and OTM. Demographic data, pre-PICU interventions (cardiopulmonary resuscitation, intubation, injury severity scores, time period before intensive care), intensive care interventions (invasive mechanical ventilation, non-invasive mechanical ventilation, need for surgery, type of surgery, need for transfusion, and inotrope therapy) were compared between two groups. Outcomes were evaluated by survival, discharge from hospital, Pediatric Cerebral Performance Category (PCPC) at discharge, tracheotomy presence, and amputation performed. RESULTS: During the 5-year study period, 135 patients were hospitalized for trauma. The injured body regions were the head and neck (61.5%), abdomen and lumbar spine (39.4%), and extremities and pelvis (36.3%). Multiple trauma was mostly seen in the MVC trauma group (p=0.001). The need for invasive mechanical ventilation and inotrope therapy was greater in the MVC group (p=0.002, 0.001 respectively). One hundred and twenty-three patients (91.1%) survived. The mortality rate was higher in the MVC group (p=0.026). The PCPC results were better in the OTM group (p=0.017). CONCLUSION: MVCs lead to more multiple trauma cases than OTMs. Invasive mechanical ventilation, inotropes, and other intensive care interventions were necessary much more often in MVC victims than in OTM patients.

Published
2022

43. COVID-19 pandemisi öncesi ve pandemi döneminde çocuk yoğun bakım ünitelerine yatan diyabetik ketoasidoz hastalarının klinik ve laboratuvar özelliklerinin değerlendirilmesi

Author

YILMAZ, RESUL, SARI, MEHMET YUSUF, AZAPAĞASI, EBRU, KIRAL, EYLEM, DİNLEYİCİ, ENER ÇAĞRI, ŞİMŞEK, ENVER, BİLGİN, MUZAFFER, KIREL, BİRGÜL, HAVAN, MERVE, KESKİN, MEHMET, KARAOĞLAN, MURAT, YILDIRIM, AHMET, KANĞIN, MURAT, KAHVECİ, FEVZİ, ARSLANOĞLU, MEHMET ÖZGÜR, TÜTÜNCÜLER KÖKENLİ, FİLİZ, YAZICI ÖZKAYA, PINAR, TURANLI, EDA, ÖZÇİFÇİ, GÖKÇEN, DURSUN, OĞUZ, ÜLGEN TEKEREK, NAZAN, TALAY, MEHMET NUR, TEKGÜÇ, HAKAN, ALAÇAKIR, NURİ, ÖZTÜRK, MAKBULE NİLÜFER, Girgin İnceköy, Feyza, ÖZDEMİR, SEMİNE, ALBAYRAK, HATİCE, YILDIZDAŞ, RIZA DİNÇER, AĞIN, HASAN, SOYDAN, EKİN, YENER, NAZİK, GÜVEN, AYLA, HANCILI, SUNA, ŞEVKETOĞLU, ESRA, AKÇAY, NİHAL, BOYRAZ, MERVE, DUYU, MUHTEREM, KOÇOĞLU BARLAS, ÜLKEM, KARAGÜZEL, GÜLAY, YEŞİLBAŞ, OSMAN, BİNGÖL, İBRAHİM, ŞIK, SARE GÜNTÜLÜ, UYSAL YAZICI, MUTLU, ÇITAK, AGOP, DURAK, CANSU, AYGÜN, FATİH, BUĞRUL, FUAT, ÖZTÜRK, ZEYNEL ABİDİN, KENDİRLİ, TANIL, YETİMAKMAN, AYŞE FİLİZ, ÜRÜN, TUBA, ALTUĞ, ÜMÜT, KESİCİ, SELMAN, TUFAN, EREN NUR, KAÇMAZ, EBRU, and BOZAN, GÜRKAN

Published
2021

44. Türkiye'de Çocuk Yoğun Bakımda COVİD-19 ile İlişkili Multisistemik İnflamatuar Sendrom Tanısı Alan Hastaların Sonuçları: Çok Merkezli Çalışma

Author

DURAK, FATİH, DUMAN, MURAT, ŞIK, SARE GÜNTÜLÜ, İNAMLIK, AYŞEGÜL, BİNGÖL, İBRAHİM, Annayev, Agageldi, ÇITAK, AGOP, AKÇAY, NİHAL, ŞEVKETOĞLU, ESRA, KESİCİ, SELMAN, Katlan, Banu, DURAK, CANSU, AYGÜN, FATİH, GÜN, EMRAH, KENDİRLİ, TANIL, ERDOĞAN, SEHER, ATAY, GÜRKAN, Sandal, Özlem, Seven, Pınar, VAROL, FATİH, ŞAHİN GÜLEÇ, EBRU, YAZICI ÖZKAYA, PINAR, ARI, HATİCE FERAY, DUYU, MUHTEREM, Boyraz, Merve, BİRBİLEN, AHMET ZİYA, EMEKSİZ, SERHAT, ÖZCAN, SERHAN, ÖZDEMİR, GÖKTUĞ, ARSLAN, GAZİ, KANĞIN, MURAT, TALAY, MEHMET NUR, BAYRAKTAR, SÜLEYMAN, Altuğ, Ümit, OTAR YENER, GÜLÇİN, ANIL, AYŞE BERNA, LÜLEYAP, DOĞA, HAVAN, MERVE, Harmanoğulları, Sezer, YETİMAKMAN ERDOĞAN, AYŞE FİLİZ, Başar, Eviç Zeynep, DALKIRAN, TAHİR, MERCAN, MEHMET, BAL, ALKAN, ZENGİN, NESLİHAN, OTO, ARZU, KILIÇ, NEVİN, KIHTIR, HASAN SERDAR, ONGUN, EBRU ATİKE, İNCEKÖY GİRGİN, FEYZA, Yalındağ Öztürk, Makbule Nilüfer, TELHAN, LEYLA, YILDIZDAŞ, RIZA DİNÇER, EKİNCİ, FARUK, YENER, NAZİK, ÜDÜRGÜCÜ, MUHAMMED, Yükselmiş, Ufuk, ALAKAYA, MEHMET, ARSLANKÖYLÜ, ALİ ERTUĞ, KILINÇ, MEHMET ARDA, KUTLU, NURETTİN ONUR, Bükülmez, Ayşe, ÇELEĞEN, MEHMET, DURSUN, ADEM, ÖZSOYLU, SERKAN, BATTAL, FATİH, Ay Subaşı, Nurcan, SARI, FERHAT, ÖZKALE, MURAT, ÖZKALE, YASEMİN, TOPAL, SEVGİ, KOCAOĞLU, ÇELEBİ, YAZAR, ABDULLAH, KILIÇ, AHMET OSMAN, ALAÇAKIR, NURİ, ÖDEK, ÇAĞLAR, and YAMAN, AYHAN

Published
2021

47. Surgical site infection rates in 16 cities in Turkey: findings of the International Nosocomial Infection Control Consortium (INICC)

Author

Leblebicioglu, Hakan, Erben, Nurettin, Rosenthal, Victor D., Sener, Alper, Uzun, Cengiz, Senol, Gunes, Ersoz, Gulden, Demirdal, Tuna, Duygu, Fazilet, Willke, Ayse, Sirmatel, Fatma, Oztoprak, Nefise, Koksal, Iftihar, Oncul, Oral, Gurbuz, Yunus, Güçlü, Ertugrul, Turgut, Huseyin, Yalcin, Ata Nevzat, Ozdemir, Davut, Kendirli, Tanil, Aslan, Turan, Esen, Saban, Ulger, Fatma, Dilek, Ahmet, Yilmaz, Hava, Sunbul, Mustafa, Ozgunes, Ilhan, Usluer, Gaye, Otkun, Metin, Kaya, Ali, Kuyucu, Necdet, Kaya, Zeynep, Meric, Meliha, Azak, Emel, Yýlmaz, Gürdal, Kaya, Selçuk, Ulusoy, Hülya, Haznedaroglu, Tuncer, Gorenek, Levent, Acar, Ali, Tutuncu, Ediz, Karabay, Oguz, Kaya, Gulsume, Sacar, Suzan, Sungurtekin, Hülya, Uğurcan, Doğaç, Turhan, Ozge, Kaya, Sehnaz, Gumus, Eylul, Dursun, Oguz, Geyik, Mehmet Faruk, Şahin, Ahmet, Erdogan, Selvi, Ince, Erdal, Karbuz, Adem, Çiftçi, Ergin, Taşyapar, Nevin, and Güneş, Melek

Published
2015
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50. Epidemiology of paediatric severe sepsis and septic shock in Turkey: Prevalence, results and treatments study.

Author

Evren, Gultac, Karaarslan, Utku, Yildizdas, Dincer, Şik, Guntulu, Azapağası, Ebru, Konca, Capan, Kendirli, Tanil, Udurgucu, Muhammed, Koroglu, Tolga Fikri, Citak, Agop, Yazici, Mutlu U., Havan, Merve, Botan, Edin, Yener, Nazik, Yilmaz, Resul, Yorulmaz, Alaaddin, Sari, Ferhat, Duyu, Muhterem, Incekoy, Feyza G., and Ozturk, Nilufer Y.

Abstract

Aim: This study was aimed at characterising the prevalence, management and outcomes of paediatric severe sepsis and septic shock in tertiary paediatric intensive care units (PICUs) in Turkey. Methods: A point prevalence study was conducted on 5 days over the course of 1 year in 29 PICUs in Turkey. Outcomes included severe sepsis and septic shock point prevalence, therapies used, duration of PICU stay and mortality at day 28. Results: Of the 1757 children who were admitted to the PICU during the study period, 141 (8.0%) children met the consensus criteria for severe sepsis and 23 (1.3%) children met the criteria for septic shock. Paediatric severe sepsis and septic shock accounted for 8% and 1.3% of all PICU admissions, respectively. The median age of the patients was 2.6 years (interquartile range [IQR], 0.7–8.6 years). Enteral nutrition (79.3%) was preferred compared to parenteral nutrition (31.1%) for the first 3 days after PICU admission. A total of 39 patients died while in the PICU, for a 23.8% mortality rate, which did not vary by age. Conclusion: The mortality rate was similar to that in other studies. Hematologic‐immunologic comorbidity, parenteral nutrition and the use of vasoactive drugs were independently associated with mortality. [ABSTRACT FROM AUTHOR]

Published
2022
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