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Telemedicine is increasingly utilized as a means to provide health care to underserved areas, including rural and urban areas without providers. The current research explores the accuracy of diagnosis, parent satisfaction and the use of two ?gold standard? measures, the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview-Revised (ADI-R) in their use in the assessment and diagnosis of children via telemedicine. Participants were children ages 3-5 with a previous diagnosis of an autism spectrum disorder (n=11), or developmental delays acting as control subjects (n=10). Participants were randomly assigned to interact with a lead psychologist through telemedicine or in person. One pair of clinicians observed in the room with families (Live) while one pair of clinicians simultaneously observed via telemedicine (Telemedicine). Each pair of clinicians provided scores on the ADOS and the ADI, as well as an overall diagnosis for the child. Inter rater agreement was computed for each pair of clinicians (item by item) and then compared to the inter rater agreement (item by item) of the other pair of clinicians with results indicating clinicians are able to score autism measures equally well in person or via telemedicine. Family satisfaction indicated families were highly satisfied in both conditions.

To develop and evaluate novel compounds which inhibit the C-terminal portion of Hsp90 in prostate cancer models. To develop a library of novobiocin analogues to be tested in vitro initially and then in a mouse model. Major findings: we have tested over 220 analogues of the original parent compound (A-1) all of which have been tested in at least two commonly used prostate cancer cell lines LNCaP and PC3. Screening has been evaluated by both Western Blot of client proteins which include the androgen receptor, Akt, Hsp90, and HER2, and MTT assay. Furthermore, with our most effective compounds we have examined the mechanism of action and have examined cell cycle data. We have evaluated one compound in vivo and are currently evaluating our newest most promising compound in vivo in an orthotopic mouse model., The original document contains color images.