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Your search keyword '"KALMES, ANDREAS"' showing total 29 results
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29 results on '"KALMES, ANDREAS"'

1. RESCUE: A Randomized, Blinded, Placebo-controlled, Parallel Group Study Design to Determine the Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy (P10-5.029)

Author

Ghosh, Supurna, primary, Dubow, Jordan, additional, Sutherland, Jocelyn, additional, Kalmes, Andreas, additional, Baird, Grayson, additional, Mock, Jarrad, additional, Smith, Wendy, additional, Cook, Douglas, additional, Madsen, Tracy E., additional, Jayaraman, Mahesh, additional, Moldovan, Krisztina, additional, Torabi, Radmehr, additional, Ansari, Sameer, additional, Favilla, Christopher, additional, Chiu, David, additional, Clark, Wayne, additional, Liebeskind, David, additional, and McTaggart, Ryan A., additional

Published
2024
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12. Additional file 2: of RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

Author

Vallarola, Antonio, Sironi, Francesca, Tortarolo, Massimo, Gatto, Noemi, Gioia, Roberta De, Pasetto, Laura, Paola, Massimiliano De, Mariani, Alessandro, Supurna Ghosh, Watson, Richard, Kalmes, Andreas, Bonetto, Valentina, and Bendotti, Caterina

Abstract

Figure S2. Representative immunoblot for GFAP performed on ventral portion of LSC of NTG mice or transgenic mice treated with NS or RNS60, at 20 weeks of age, and relative quantification. Data are expressed as mean ± SEM, (n = 5 animals per group). Data were statistically analyzed using one way ANOVA followed by post hoc Fisher’s LSD. * = p

Published
2018
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13. Additional file 3: of RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

Author

Vallarola, Antonio, Sironi, Francesca, Tortarolo, Massimo, Gatto, Noemi, Gioia, Roberta De, Pasetto, Laura, Paola, Massimiliano De, Mariani, Alessandro, Supurna Ghosh, Watson, Richard, Kalmes, Andreas, Bonetto, Valentina, and Bendotti, Caterina

Abstract

Figure S3. A-D) Representative images of LSC micrographs stained with S100β (green) and GFAP (red) at 20 weeks of age. Scale bar: 20 μm. E) Quantification of immunofluorescence showed no differences between the two transgenic groups. Bar graphs represents mean ± SEM, (n = 5 animals per group); One-way ANOVA followed by post hoc Fisher’s LSD non-parametric test (p = 0.420). (DOCX 1342 kb)

Published
2018
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24. A serine-kinase associated with the p127-l(2)gl tumour suppressor of Drosophila may regulate the binding of p127 to nonmuscle myosin II heavy chain and the attachment of p127 to the plasma membrane

Author

Kalmes, Andreas, Merdes, Gunter, Neumann, Beate, Strand, Dennis, and Mechler, Bernard M.

Abstract

The p127 tumour suppressor protein encoded by the lethal(2)giant larvae, [l(2)gl], gene of Drosophila melanogaster is a component of a cytoskeletal network dis-tributed in both the cytoplasm and on the inner face of the plasma membrane. The p127 protein forms high molecular mass complexes consisting mainly of homo-oligomerized p127 molecules and at least ten additional proteins. One of these proteins has been recently identified as nonmuscle myosin type II heavy chain. To determine the functional interactions between p127 and other proteins present in the p127 complexes, we analyzed p127 for posttranslational modifications and found that p127 can be phosphorylated at serine residues. In this report we describe the charac-teristics of a serine kinase which is associated with p127, as judged by its recovery in p127 complexes purified by either gel filtration or immuno-affinity chromatography. This kinase phosphorylates p127 in vitro and its activation by supplementing ATP results in the release of p127 from the plasma membrane. Moreover, similar activation of the kinase present in immuno-purified p127 complexes dissociates nonmuscle myosin II from p127 without affecting the homo-oligomerization of p127. This dissociation can be inhibited by staurosporine and a 26mer peptide covering amino acid positions 651 to 676 of p127 and containing five serine residues which are evolutionarily conserved from Drosophila to humans. These results indicate that a serine-kinase tightly associated with p127 regulates p127 binding with components of the cytoskeleton present in both the cytoplasm and on the plasma membrane.

Published
1996
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25. Additional file 1: of RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

Author

Vallarola, Antonio, Sironi, Francesca, Tortarolo, Massimo, Gatto, Noemi, Gioia, Roberta De, Pasetto, Laura, Paola, Massimiliano De, Mariani, Alessandro, Supurna Ghosh, Watson, Richard, Kalmes, Andreas, Bonetto, Valentina, and Bendotti, Caterina

Subjects
3. Good health
Abstract

Figure S1. Primary microglia-MN enriched co-cultures exposed to LPS for 24 h after 6 DIV. The bar graph indicates that LPS reduces the viability of MNs treated with 10% (v/v) NS or ONS60 (ONS) by about 30%. The toxic effect was significantly prevented by RNS60 (10% v/v). Data are expressed as mean ± SEM (n = 6), One-way ANOVA (p

26. Additional file 1: of RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

Author

Vallarola, Antonio, Sironi, Francesca, Tortarolo, Massimo, Gatto, Noemi, Gioia, Roberta De, Pasetto, Laura, Paola, Massimiliano De, Mariani, Alessandro, Supurna Ghosh, Watson, Richard, Kalmes, Andreas, Bonetto, Valentina, and Bendotti, Caterina

Subjects
3. Good health
Abstract

Figure S1. Primary microglia-MN enriched co-cultures exposed to LPS for 24 h after 6 DIV. The bar graph indicates that LPS reduces the viability of MNs treated with 10% (v/v) NS or ONS60 (ONS) by about 30%. The toxic effect was significantly prevented by RNS60 (10% v/v). Data are expressed as mean ± SEM (n = 6), One-way ANOVA (p

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