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17 results on '"K.K. Brown"'

10. Does HRCT Pattern Influence the Effect of Nintedanib in Patients with Progressive Fibrosing Interstitial Lung Diseases?

Author

K.K. Brown, S.L.F. Walsh, A. Devaraj, J.W. Song, W.A. Wuyts, C. Valenzuela, R.-G. Goeldner, S. Stowasser, R. Schlenker-Herceg, A.U. Wells, and null on behalf of the INBUILD trial investigators

Subjects
medicine.medical_specialty, chemistry.chemical_compound, Lung, medicine.anatomical_structure, chemistry, business.industry, Internal medicine, Medicine, In patient, Nintedanib, business, Gastroenterology
Published
2020
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12. Characteristics of Patients with Progressive Fibrosing Interstitial Lung Diseases (ILDs) in the INBUILD Trial of Nintedanib

Author

K.R. Flaherty, A.U. Wells, E. Clerisme-Beaty, V. Cottin, A. Devaraj, Y. Inoue, L. Richeldi, S. Walsh, R.-G. Goeldner, R. Schlenker-Herceg, K.K. Brown, and null on behalf of the INBUILD trial inve

Subjects
medicine.medical_specialty, chemistry.chemical_compound, Lung, medicine.anatomical_structure, chemistry, business.industry, Internal medicine, medicine, Nintedanib, business, Gastroenterology
Published
2019
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13. Circulating Plasma Proteins Differentially Detected in Idiopathic Pulmonary Fibrosis and in Subjects with Pre-Clinical Pulmonary Fibrosis

Author

Mark P. Steele, Ivana V. Yang, K.K. Brown, Susan K. Mathai, Oliver Eickelberg, J.E. Loyd, Marvin I. Schwarz, Julia Powers, Jonathan Cardwell, T.E. Fingerlin, Stefanie M. Hauck, D.A. Lynch, Jonathan A. Kropski, Avram D Walts, David A. Schwartz, Fabian Metzger, and Cheryl Markin

Subjects
Pathology, medicine.medical_specialty, Idiopathic pulmonary fibrosis, business.industry, Pulmonary fibrosis, Medicine, business, medicine.disease, Blood proteins
Published
2019
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15. INTERSTITIAL LUNG DISEASE | Overview

Author

G.P. Cosgrove and K.K. Brown

Subjects
medicine.medical_specialty, business.industry, Mechanism (biology), Interstitial lung disease, Disease, respiratory system, medicine.disease, respiratory tract diseases, Idiopathic pulmonary fibrosis, Pulmonary fibrosis, Pulmonary medicine, Medicine, business, Intensive care medicine
Abstract

Comprised of over 150 named disorders, interstitial lung disease (ILD) is a complex area of pulmonary medicine for generalists and experts alike. While many of the disorders share common clinical features, the mechanism of disease, outcome, type, or even availability of therapy for each specific disease often differs dramatically. An accurate diagnosis is therefore essential for the determination of prognosis and appropriate management. This article provides a framework for the classification and evaluation of patients with ILD.

Published
2006
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16. Biological Monitoring for Selected Herbicide Biomarkers in the Urine of Exposed Custom Applicators: Application of Mixed-effect Models.

Author

C.J. Hines, J.A. Deddens, C.A.F. Striley, R.E. Biagini, D.A. Shoemaker, K.K. Brown, B.A. Mackenzie, and R.D. Hull

Subjects
METABOLITES, HERBICIDES, ESTERS
Abstract

Metabolites and/or parent compounds of the herbicides atrazine, alachlor, metolachlor, cyanazine and the 2-ethylhexyl ester of 2,4-dichlorophenoxyacetic acid (2,4-D) were measured in the urine of 15 custom applicators who each provided from five to seven 24 h urine samples during a 6 week period (n = 87). Each applicator provided a pre-season urine sample and a reference population (n = 46) provided first-morning urine samples. Urinary biomarkers were measured by either immunoassay or gas chromatography. During the spraying season, the geometric mean amount of alachlor mercapturate equivalents (eq.), atrazine eq., 2,4-D and metolachlor mercapturate eq. excreted in 24 h was 17, 19, 110 and 22 nmol, respectively. Mixed-effect models were used to determine predictors of the amount of atrazine eq. and 2,4-D excreted in 24 h. The specific days of herbicide spraying associated with increased biomarker excretion varied for the two analytes, and included one or more days prior to urine collection. This confirms the importance of collecting covariate information on day(s) most relevant to the biomarker of interest. The within-worker variance component, expressed as a geometric standard deviation (WGSD range: 2.5-2.9), was substantially larger than the between-worker component (BGSD range: 1.3-1.5) for the modeled biomarkers. Alachlor mercapturate eq. and metolachlor mercapturate eq. were detected in more than half of the applicator pre-season urine samples. All biomarkers were detected infrequently in the reference population. Evaluation of non-spray exposure determinants was limited by inclusion of prior day spraying, adjustment for time and the small sample size. [ABSTRACT FROM AUTHOR]

Published
2003
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17. Trace Level Quantitation of Phenyltin Compounds Using HPTLC

Author

K.K. Brown, P. Tomboulian, and S.M. Walters

Subjects
chemistry.chemical_compound, Chromatography, chemistry, Acrolein, General Engineering, Acetone, Acetaldehyde, Propionaldehyde, Article
Abstract

The monitoring of LO, for 6-15 days has been carried out several times in the metropolitan area of Tokyo since November 1985, and data on more than 1800 samples have been obtained. Acetaldehyde, C,-C 3 alcohols, and acetone were constantly observed in chromatograms. Acrolein, C 2 -C 3 esters, propionaldehyde, C 4 C5 ethers, and methylethylketone were occasionally detected. This system has worked satisfactorily for more than 2500 hours without any exchange of parts in the devices, and has proved to be practical and durable.

Published
1988

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