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1. Outcomes and toxicities in oligometastatic patients treated with stereotactic body radiotherapy for adrenal gland metastases: A multi-institutional retrospective study

Author

A. Baydoun, H. Chen, I. Poon, S. Badellino, R. Dagan, D. Erler, M.C. Foote, A.V. Louie, K.J. Redmond, U. Ricardi, A. Sahgal, and T. Biswas

Subjects
Adrenal gland metastases, SBRT, Oligometastases, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Studies reporting SBRT outcomes in oligometastatic patients with adrenal gland metastases (AGM) are limited. Herein, we present a multi-institutional analysis of oligometastatic patients treated with SBRT for AGM. Material/methods: The Consortium for Oligometastases Research (CORE) is among the largest retrospective series of patients with oligometastases. Among CORE patients, those treated with SBRT for AGM were included. Clinical and dosimetric data were collected. Adrenal metastatic burden (AMB) was defined as the sum of all adrenal GTV if more than one oligometastases is present.Competing risk analysis was used to estimate actuarial cumulative local recurrence (LR) and widespread progression (WP). Kaplan-Meier method was used to report overall survival (OS), local recurrence-free survival (LRFS), and progression-free survival (PFS). Treatment related toxicities were also reported. Results: The analysis included 47 patients with 57 adrenal lesions. Median follow-up was 18.2 months. Median LRFS, PFS, and OS were 15.3, 5.3, and 19.1 months, respectively. A minimum PTV dose BED10 > 46 Gy was associated with an improved OS and LRFS. A prescribed BED10 > 70 Gy was an independent predictor of a lower LR probability. AMB>10 cc was an independent predictor of a lower risk for WP. Only one patient developed an acute Grade 3 toxicity consisting of abdominal pain. Conclusion: SBRT to AGM achieved a satisfactory local control and OS in oligometastatic patients. High minimum PTV dose and BED10 prescription doses were predictive of improved LR and OS, respectively. Prospective studies are needed to determine comprehensive criteria for patients SBRT eligibility and dosimetric planning.

Published
2022
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5. Evolving Role of Stereotactic Body Radiation Therapy in the Management of Spine Metastases

Author

William C. Jackson, Fabio Y. Moraes, Yoshiya Yamada, Xuguang Chen, Daniel E. Spratt, K.J. Redmond, and Michael Yan

Subjects
Tumor histology, medicine.medical_specialty, Stereotactic body radiation therapy, business.industry, Salvage treatment, General Medicine, Dose constraints, Single fraction, 03 medical and health sciences, 0302 clinical medicine, Treatment success, 030220 oncology & carcinogenesis, medicine, Surgery, Neurology (clinical), Radiology, Radiation treatment planning, business, Solid tumor, 030217 neurology & neurosurgery
Abstract

When treating solid tumor spine metastases, stereotactic high-dose-per-fraction radiation, given in a single fraction or in a hypofractionated approach, has proved to be a highly effective and safe therapeutic option for any tumor histology, in the setting of de novo therapy, as salvage treatment of local progression after previous radiation, and in the postoperative setting. There are variations in practice based on the clinical presentation, goals of therapy, as well as institutional preferences. As a biologically potent therapy, a thoughtful and careful attention to detail with patient selection, treatment planning, and delivery is crucial for treatment success.

Published
2020
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6. Radiation Immunodynamics as the Foundation of Immune-Guided Radiotherapy: Changes in Peripheral CD14+PD-L1+ Myeloid Cells over the Course of Chemoradiation and Association with Survival for New Diagnosis of Glioblastoma

Author

L. Sloan, R. Sen, C. Hu, C. Liu, M. Doucet, L. Blosser, E. Thompson, L. Katulis, D. Kamson, S. Grossman, M. Holdhoff, K.J. Redmond, H. Quon, M. Lim, C. Eberhart, D.M. Pardoll, S. Ganguly, and L.R. Kleinberg

Subjects
Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
Published
2022
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13. Conditional Survival of Extracranial Oligometastatic Patients Treated with Stereotactic Body Radiation Therapy (SBRT): An International Consortium Study

Author

A.V. Louie, Umberto Ricardi, Ian Poon, Darby Erler, Roi Dagan, Hanbo Chen, Serena Badellino, K.J. Redmond, Matthew Foote, Tithi Biswas, and Arjun Sahgal

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Oncology, Conditional survival, business.industry, Stereotactic body radiation therapy, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, business
Published
2020
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14. Oligoprogressive Metastatic Lung Cancer Treated with Definitive Radiotherapy without a Change in Systemic Therapy

Author

Russell K. Hales, Chen Hu, Peijin Han, K.J. Redmond, Patrick M. Forde, Todd McNutt, Cole Friedes, Wei Fu, Nicholas Mai, Khinh Ranh Voong, and Sarah Z. Hazell

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, Internal medicine, medicine, Metastatic lung cancer, Radiology, Nuclear Medicine and imaging, business, Systemic therapy, Definitive radiotherapy
Published
2020
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17. International Consensus Contouring Recommendations for Stereotactic Body Radiotherapy of Non-Spine Bone Metastases

Author

K.J. Redmond, Jin Ho Kim, Arjun Sahgal, Shankar Siva, Timothy K. Nguyen, Chia-Lin Tseng, Simon S. Lo, Wietse Eppinga, M. Guckenberger, Roi Dagan, Lee Chin, and Bradley J. Stish

Subjects
Spine (zoology), Cancer Research, medicine.medical_specialty, Contouring, Radiation, Oncology, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Stereotactic body radiotherapy
Published
2020
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18. The Immunodynamics of Myeloid-Derived Suppressor Cell and Monocyte Populations in the Peripheral Blood in Patients with Newly Diagnosed Glioblastoma Undergoing Adjuvant Temozolomide and Radiation Therapy

Author

Chen Hu, C. Eberhart, Harry Quon, M. Doucet, J. Wemmer, K.J. Redmond, Michael Lim, Zhi Cheng, Drew M. Pardoll, Ilya Shpitser, L. Katulis, S. Ganguly, Christopher M. Jackson, Todd McNutt, Matthias Holdhoff, L. Sloan, L.R. Kleinberg, Stuart A. Grossman, R. Sen, and L. Blosser

Subjects
Cancer Research, Radiation, Temozolomide, business.industry, medicine.medical_treatment, Monocyte, medicine.disease, Peripheral blood, Radiation therapy, medicine.anatomical_structure, Oncology, Myeloid-derived Suppressor Cell, Cancer research, Medicine, Radiology, Nuclear Medicine and imaging, In patient, business, Adjuvant, medicine.drug, Glioblastoma
Published
2019
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19. Stereotactic Body Radiotherapy for Non-Spine Bone Metastases: An International Survey of Practice Patterns

Author

Simon S. Lo, Arjun Sahgal, Chia-Lin Tseng, Timothy K. Nguyen, Roi Dagan, Wietse Eppinga, Shankar Siva, Lee Chin, Bradley J. Stish, K.J. Redmond, Matthias Guckenberger, and Jin Ho Kim

Subjects
Spine (zoology), Cancer Research, medicine.medical_specialty, Radiation, Oncology, Practice patterns, business.industry, medicine, International survey, Radiology, Nuclear Medicine and imaging, Radiology, business, Stereotactic body radiotherapy
Published
2019
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20. Reduction in Whole Brain Volume is Associated with Decline in Verbal Memory Following Prophylactic Cranial Irradiation for Limited-Stage Small-Cell Lung Cancer

Author

M. Duhon, Russell K. Hales, Khinh Ranh Voong, Haris I. Sair, Jimm Grimm, N. Chintalapati, Chengcheng Gui, K.J. Redmond, Tracy D. Vannorsdall, and L.R. Kleinberg

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Limited stage small cell lung cancer, Internal medicine, Brain size, medicine, Radiology, Nuclear Medicine and imaging, Prophylactic cranial irradiation, Verbal memory, business, Reduction (orthopedic surgery)
Published
2019
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21. Concurrent Immunotherapy Usage and Asymmetric Growth May Distinguish True Progression from Treatment Effect in Growing Brain Metastases after Stereotactic Radiosurgery

Author

Jimm Grimm, Peijin Han, Chengcheng Gui, B.R. Baker, Khadija Sheikh, L. Chen, Heather M. Ames, K.J. Redmond, Adam Robinson, Junghoon Lee, F. Silvestri, Colette J. Shen, T. Kirschbaum, L.C. Peng, Michael Lim, Ellen Huang, L.R. Kleinberg, and J. Son

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Immunotherapy, Asymmetric growth, Radiosurgery, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, Treatment effect, business
Published
2018
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22. Application of Machine Learning and Radiomics to Distinguish True Progression From Treatment Effect after Stereotactic Radiation Therapy for Brain Metastases

Author

Adam Robinson, K.J. Redmond, Michael Lim, Peng Huang, Colette J. Shen, F. Silvestri, L.R. Kleinberg, Emory R. McTyre, L. Chen, Jimm Grimm, B.R. Baker, Michael A. Jacobs, T. Kirschbaum, Khadija Sheikh, Michael H. Soike, L.C. Peng, Heather M. Ames, Vishwa S. Parekh, J. Son, and Junghoon Lee

Subjects
Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Stereotactic radiation therapy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Oncology, Radiomics, 030220 oncology & carcinogenesis, Medicine, Radiology, Nuclear Medicine and imaging, Treatment effect, Radiology, business
Published
2018
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23. Hypofractionated Stereotactic Radiotherapy to the Resection Cavity in Patients with Brain Metastases: An International Multi-Institutional Analysis of Prognostic Factors and Outcomes

Author

A. M. S. Kumar, Chengcheng Gui, Arjun Sahgal, Wenyin Shi, Matthew Foote, K. A. Kessel, Andrew Song, Stephanie E. Combs, Hany Soliman, Simon S. Lo, Mark B. Pinkham, Mitchell Machtay, K.J. Redmond, and A. Theriault

Subjects
Stereotactic radiotherapy, Cancer Research, medicine.medical_specialty, Radiation, Oncology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, In patient, Resection Cavity, Radiology, business
Published
2019
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24. A Dose-Response Model of Local Tumor Control Probability after Stereotactic Radiosurgery for Brain Metastases Resection Cavities

Author

Peter Zaki, Chengcheng Gui, Michael Lim, L.R. Kleinberg, Chetan Bettegowda, Nicholas Spoleti, Jimm Grimm, and K.J. Redmond

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Response model, business.industry, medicine.medical_treatment, Tumor control, Radiosurgery, Resection, Oncology, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business
Published
2019
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25. Low Risk of Symptomatic Radionecrosis Following Stereotactic Radiosurgery for Multiple Brain Metastases

Author

D. Nikolaidis, Chetan Bettegowda, Ellen Huang, Colette J. Shen, Y. Seo, L. Chan, Sarah Z. Hazell, Michael Lim, Joseph O. Moore, L. Sloan, L.R. Kleinberg, K.J. Redmond, Harry Quon, and Jimm Grimm

Subjects
Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Radiosurgery, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business
Published
2017
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26. Nelfinavir induces radiation sensitization in pituitary adenoma cells

Author

Stephanie A. Terezakis, Alfred P. See, Michael Armour, Roberto Salvatori, Lawrence Kleinberg, Rajendra P. Gajula, Saravanan Thiyagarajan, Alfredo Quinones-Hinojosa, K.J. Redmond, Jillian Phallen, Phuoc T. Tran, T. Salih, Khaled Aziz, Russell K. Hales, Jing Zeng, and Michael Lim

Subjects
Adenoma, Radiation-Sensitizing Agents, Cancer Research, Radiosensitizer, endocrine system diseases, Cell Survival, Mice, Nude, Apoptosis, Pharmacology, Pituitary neoplasm, Biology, Article, Mice, Phosphatidylinositol 3-Kinases, immune system diseases, In vivo, medicine, Animals, Humans, Pituitary Neoplasms, Viability assay, Annexin A5, Clonogenic assay, Nelfinavir, Caspase 3, TOR Serine-Threonine Kinases, Cell Cycle, virus diseases, Neoplasms, Experimental, biochemical phenomena, metabolism, and nutrition, medicine.disease, Xenograft Model Antitumor Assays, Prolactin, stomatognathic diseases, Oncology, Molecular Medicine, Female, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug
Abstract

Pituitary adenomas with local invasion and high secretory activity remain a therapeutic challenge. The HIV protease inhibitor nelfinavir is a radiosensitizer in multiple tumor models. We tested nelfinavir as a radiosensitizer in pituitary adenoma cells in vitro and in vivo. We examined the effect of nelfinavir with radiation on in vitro cell viability, clonogenic survival, apoptosis, prolactin secretion, cell cycle distribution, and the PI3K-AKT-mTOR pathway. We evaluated tumor growth delay and confirmed nelfinavir's effect on the PI3K-AKT-mTOR pathway in a hind-flank model. Nelfinavir sensitized pituitary adenoma cells to ionizing radiation as shown by viability assays and clonogenic assay with an enhancement ratio of 1.2 (p < 0.05). There is increased apoptotic cell death, as determined by annexin-V expression and cleaved caspase-3 levels. Nelfinavir does not affect prolactin secretion or cell cycle distribution. In vivo, untreated tumors reached 4-fold volume in 12 days, 17 days with nelfinavir treatment, 27 days with radiation 6 Gy, and 41 days with nelfinavir plus radiation (one-way ANOVA p < 0.001). Decreased phospho-S6 on Western blotting in vitro and immunohistochemistry in vivo demonstrated nelfinavir inhibition of the PI3K-AKT-mTOR pathway. Our data suggests a promising combination therapy with nelfinavir plus radiation in pituitary adenomas, which should be investigated in clinical studies.

Published
2011
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27. Impact of Corticosteroids on the Efficacy of Anti-PD-1 Therapy for Tumors Located Within or Outside the Central Nervous System

Author

Michael Lim, Phuoc T. Tran, Andrew S. Luksik, Debebe Theodros, Christopher M. Jackson, Henry Brem, Zineb Belcaid, Yuanxuan Xia, K.J. Redmond, L.R. Kleinberg, Tomas Garzon-Muvdi, N. Gorelick, A. Wu, Eileen Kim, A.L. Hung, Xiaobu Ye, Russell Maxwell, and Drew M. Pardoll

Subjects
Cancer Research, Radiation, business.industry, Anti pd 1, Central nervous system, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Medicine, Radiology, Nuclear Medicine and imaging, business, 030217 neurology & neurosurgery
Published
2018
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28. Toxicity and Local Control Outcomes for Brain Metastases Managed with Resection and Aggressive Reirradiation after Initial Radiosurgery Failure

Author

Michael Lim, B.R. Baker, C. Siu, L.C. Peng, Chetan Bettegowda, Megan N. Kummerlowe, Colette J. Shen, L.R. Kleinberg, K. Schlosser, Yuanxuan Xia, and K.J. Redmond

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Oncology, business.industry, medicine.medical_treatment, Toxicity, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Radiosurgery, Resection
Published
2018
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29. Consensus Guidelines for Target Volume Definition of the Sacrum in Spinal Stereotactic Body Radiation Therapy (SBRT)

Author

Samuel T. Chao, Eric L. Chang, Salman Faruqi, Scott G. Soltys, K.J. Redmond, Ung Kyu Chang, Alanah Bergman, Arjun Sahgal, Simon S. Lo, Mitchell Liu, Amol J. Ghia, Robert Kosztyla, and Emma M. Dunne

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Oncology, business.industry, Stereotactic body radiation therapy, Planning target volume, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, Sacrum, business
Published
2018
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30. Imaging and Clinical Profile of Concurrent Stereotactic Radiation and Immune Therapy for Melanoma Brain Metastases

Author

Katherine E. Link, L.R. Kleinberg, Colette J. Shen, J. Hoare, K.J. Redmond, Doris D. M. Lin, Michael Lim, Chetan Bettegowda, Jimm Grimm, and L. Sloan

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, Melanoma, medicine.disease, Immune therapy, Stereotactic radiation, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business
Published
2017
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31. Rate of Intralesional Hemorrhage in Hypofractionated Stereotactic Radiosurgery for Brain Metastases in Patients with Metastatic Melanoma Treated with Concurrent Immunotherapy

Author

K.J. Redmond, Jimm Grimm, Chetan Bettegowda, Katherine E. Link, L. Sloan, Colette J. Shen, Doris D. M. Lin, Michael Lim, and L.R. Kleinberg

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Radiation, Metastatic melanoma, business.industry, medicine.medical_treatment, Immunotherapy, Radiosurgery, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, In patient, business
Published
2017
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32. Survival Outcomes Following Combination Radiotherapy and Immune Checkpoint Inhibitors

Author

Todd McNutt, Jacqueline Douglass, L.R. Kleinberg, Mark Yarchoan, Michael Lim, Stuart A. Grossman, K.J. Redmond, Ariel E. Marciscano, L. Chen, and Adam Diehl

Subjects
Radiation therapy, Oncology, Cancer Research, medicine.medical_specialty, Radiation, business.industry, Immune checkpoint inhibitors, Internal medicine, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, business
Published
2017
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33. BRAF-V600 Mutational Status is a Significant Associate of Brain Metastases Recurrence in Patients With Melanoma: A Retrospective Study

Author

Russell Maxwell, Michael Lim, William H. Sharfman, Xiaobu Ye, L.R. Kleinberg, Chetan Bettegowda, and K.J. Redmond

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Pathology, Radiation, business.industry, Melanoma, Retrospective cohort study, medicine.disease, Internal medicine, medicine, Mutational status, Radiology, Nuclear Medicine and imaging, In patient, business
Published
2015
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34. Diffusion Tensor Imaging (DTI) and Proton MR Spectroscopy (MRS) Detected Region Specific Injury to White Matter in Children Treated With Cranial Irradiation

Author

Todd McNutt, Moody D. Wharam, Stephanie A. Terezakis, L.R. Kleinberg, K.J. Redmond, Alena Horská, E.M. Mahone, Haris I. Sair, and Tracy D. Vannorsdall

Subjects
Cancer Research, Radiation, business.industry, Proton mr spectroscopy, White matter, medicine.anatomical_structure, Oncology, Cranial Irradiation, Region specific, medicine, Radiology, Nuclear Medicine and imaging, business, Nuclear medicine, Diffusion MRI
Published
2014
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35. Reduced Lymphocytopenia Following Stereotactic Body Radiation Therapy (SBRT) for Spine Metastases Compared With Conventional Radiation Therapy (CRT)

Author

Jean Paul Wolinsky, L.R. Kleinberg, Ziya L. Gokaslan, Chetan Bettegowda, Daniel M. Sciubba, K. Gokce, Sara R. Alcorn, K.J. Redmond, Michael Lim, Susannah G. Ellsworth, Stuart A. Grossman, U. Hadelsberg, and Omar Y. Mian

Subjects
Cancer Research, medicine.medical_specialty, Radiation, business.industry, Stereotactic body radiation therapy, medicine.medical_treatment, medicine.disease, Radiation therapy, Oncology, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Radiology, Lymphocytopenia, business
Published
2014
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36. Consensus Guidelines Postoperative Stereotactic Body Radiation Therapy (SBRT) for Malignant Spinal Tumors: Results of an International Survey

Author

Iris C. Gibbs, Simon S. Lo, Samuel Ryu, Peter C. Gerszten, Samuel T. Chao, Arjun Sahgal, Michael G. Fehlings, Eric L. Chang, L.D. Rhines, and K.J. Redmond

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Oncology, Stereotactic body radiation therapy, business.industry, medicine, International survey, Radiology, Nuclear Medicine and imaging, Medical physics, business
Published
2014
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37. A Multinational Report on Image-Guided Stereotactic Body Radiation Therapy for Oligometastases: Patient Selection and Follow-Up

Author

Umberto Ricardi, Arjun Sahgal, Matthew Foote, Frank Lohr, Ian Poon, Roi Dagan, Simon S. Lo, and K.J. Redmond

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Radiation, Oncology, Stereotactic body radiation therapy, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Selection (genetic algorithm)
Published
2014
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38. Echo-Planar MR Spectroscopic Imaging Pre and Post Radiation Therapy in Patients With High Grade Glioma

Author

Peter B. Barker, L.R. Kleinberg, Anouk Marsman, Doris D. M. Lin, Andrew A. Maudsley, K.J. Redmond, and Sulaiman Sheriff

Subjects
Cancer Research, medicine.medical_specialty, Radiation, business.industry, medicine.medical_treatment, Salvage therapy, Histology, Clinical trial, Radiation therapy, Oncology, Mr spectroscopic imaging, Medicine, Radiology, Nuclear Medicine and imaging, In patient, Radiology, business, Adjuvant, High-Grade Glioma
Abstract

Twenty-three tumors had a gross total resection (GTR) alone, 13 had a GTR followed by adjuvant RT (GTR + RT), 5 had a subtotal resection (STR) alone, and 8 had STR and adjuvant RT (STR + RT). The median RT dose was 54 Gy (range 54-60) for atypical and 60 Gy (range 54-60) for anaplastic histology, typically prescribed to the cavity or enhancement with a 0.7-1.5 cm expansion for atypical tumors and 3-4 cm for malignant histology. Patients who recurred were treated with salvage therapy (re-resection, RT, or both). Failure after salvage and the number of salvage treatments were identified. Results: With a median follow-up time of 2.9 years, 18 of 49 patients recurred. Table 1 presents the recurrence, overall survival (OS), and salvage data based on surgery and RT characteristics and compares the sub-groups. Notably, there were significantly fewer failures after salvage and fewer salvage procedures in the GTR+RT group than the GTR alone group (PZ0.027 and 0.019, respectively) Conclusion: These retrospective data report outcomes for patients treated with surgery with and without adjuvant RT and provide some insight regarding salvage for patients who progress. While this study is underpowered to make statistical comparisons regarding initial failure rates, these data suggest that adjuvant fractionated RT following resection of AM reduces local recurrence and subsequent salvage procedures for patients who had a GTR. The RTOG is currently developing a clinical trial to investigate this question in a prospective multi-institutional fashion. Author Disclosure: R.V. Hymas: None. M.A. Taquee: None. I.S. Grills: None. P.Y. Chen: None. D.J. Krauss: None. K. Marvin: None. H. Ye: None. J.T. Dilworth: None.

Published
2015
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39. Timely Radiosurgery for Spine Metastases per RTOG 0613 Guidelines Using a Rapidly Deployable Automated Planning Script

Author

Michael Lim, Todd McNutt, K.J. Redmond, Daniele Rigamonti, O. Thomas, L.R. Kleinberg, Yi Le, and Omar Y. Mian

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Oncology, business.industry, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Radiology, business, Radiosurgery
Published
2013
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40. A Prospective Study of Corpus Callosum Regional Volumes and Neurocognitive Outcomes Following Cranial Radiation for Pediatric Brain Malignancies

Author

Wendy R. Kates, K.J. Redmond, Ashwin N. Ram, Moody D. Wharam, Stephanie A. Terezakis, M. Mahone, Alena Horská, and A. LaClair

Subjects
Cancer Research, medicine.medical_specialty, Pathology, Radiation, business.industry, Corpus callosum, Cranial radiation, Oncology, Pediatric brain, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Prospective cohort study, Neurocognitive
Published
2013
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41. Long-Term Follow-Up of Adaptive Multistage Stereotactic Radiosurgery for Treatment of High-Grade Arteriovenous Malformations

Author

Judy Huang, Mohamed H. Khattab, Ariel E. Marciscano, Michael Lim, L.R. Kleinberg, K.J. Redmond, Daniele Rigamonti, and Rafael J. Tamargo

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Oncology, business.industry, Long term follow up, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Radiosurgery
Published
2014
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42. MR Enhancement as a Predictor for Malignant Degeneration in Progressive Low-Grade Gliomas: An Update With Survival Analysis

Author

Alessandro Olivi, Amol Narang, K.J. Redmond, Jon D. Weingart, L.R. Kleinberg, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana, and Michael Lim

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Radiation, Oncology, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Degeneration (medical), business, Survival analysis
Published
2014
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43. A Multi-National Report on Technical Factors of Stereotactic Body Radiation Therapy for Oligometastases

Author

K.J. Redmond, Roi Dagan, Umberto Ricardi, Simon S. Lo, Matthew Foote, Arjun Sahgal, Frank Lohr, and Ian Poon

Subjects
Cancer Research, medicine.medical_specialty, Radiation, Stereotactic body radiation therapy, business.industry, University hospital, Multi national, Oncology, Family medicine, Medicine, Radiology, Nuclear Medicine and imaging, Center (algebra and category theory), University medical, business
Abstract

A Multi-National Report on Technical Factors of Stereotactic Body Radiation Therapy for Oligometastases S.S. Lo, K.J. Redmond, I. Poon, M.C. Foote, R. Dagan, F. Lohr, U. Ricardi, and A. Sahgal; University Hospitals Seidman Cancer Center, Cleveland, OH, Johns Hopkins University, Baltimore, MD, Odette Cancer CentreSunnybrook Health Sciences, Toronto, ON, Canada, Princess Alexandra Hospital, Woolloongabba, Australia, University of Florida, Jacksonville, FL, University Medical Center Mannheim, University of Heidelberg, Mannheim, Mannheim, Germany, University of Torino, Torino, Italy, Sunnybrook Health Sciences Center, Toronto, ON, Canada

Published
2014
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46. Interfraction Variations in Respiratory Phase Offset between Tumor and Xyphoid: Dosimetric Consequences during Respiratory Gated Stereotactic Radiotherapy for Lung Cancer

Author

K.J. Redmond, Danny Y. Song, Eric W. Ford, K. Smith, and John Wong

Subjects
Cancer Research, medicine.medical_specialty, Radiation, business.industry, Respiratory phase, medicine.disease, Stereotactic radiotherapy, Oncology, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, Respiratory system, business, Lung cancer
Published
2008
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47. Prospective Study of Proton MR Spectroscopy (MRS) and Neuro-Psychological Dysfunction following Cranial Irradiation for Pediatric Malignancies

Author

Moody D. Wharam, L.R. Kleinberg, Mahaveer Degaonkar, Stephanie A. Terezakis, Alena Horská, Haris I. Sair, Todd McNutt, Omar Y. Mian, E.M. Mahone, and K.J. Redmond

Subjects
Cancer Research, Radiation, Oncology, Cranial Irradiation, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, business, Nuclear medicine, Prospective cohort study, Psychological dysfunction, Proton mr spectroscopy
Published
2013
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48. Predictors of High-Grade Histology in Patients With Progressive Low-Grade Gliomas: Is Histology Needed to Guide Therapy?

Author

Jon D. Weingart, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana, Alessandro Olivi, L.R. Kleinberg, Amol Narang, Michael Lim, D. Vaidya, and K.J. Redmond

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Radiation, business.industry, Parietal lobe, Histology, medicine.disease, Temporal lobe, Breast cancer, Oncology, Frontal lobe, medicine, Hippocampus (mythology), Radiology, Nuclear Medicine and imaging, Occipital lobe, Nuclear medicine, business, Brain metastasis
Abstract

with the individual hippocampi in cranial contrast-enhanced T1-weighted MRIs. Most frequent primary tumors were non-small cell lung cancer in male patients (52%) and breast cancer (25%) in female patients. For each MRI, the distance from the center (CoM) and the border (BoM) of each mass to the closest hippocampus was calculated and the distribution of metastases was fitted to a normalized brain map. Results: Of all metastases, 26% were located in the frontal lobe and the cerebellum, 20% in the parietal lobe, 13% in the temporal lobe, 9% in the occipital lobe and 6% in other brain structures. Only 0.4% of metastases (n Z 3; 2 SCLC, 1 adeno-NSCLC) found in 3 patients (3%) had their CoM inside the hippocampus. A total of 1.1% of all metastases (nZ 9; 5 adenoNSCLC, 3 SCLC, 1 NCC) with external CoM were infiltrating the hippocampus (in 9 patients, 9%). Ninety-one percent (n Z 777) of all analyzed metastases had a CoM with more than 1.5 cm distance from the hippocampus (69 patients, 69%). Eighty-four percent (n Z 718) of metastases showed more than 1.5 cm distance between the borders and the hippocampus, which was the case in 48 patients (48%). Conclusions: Assuming a radial growth of brain metastases the hippocampal region appears to be a rare site of metastases. If HS-PCI would have been applied, most patients would have been adequately treated. However, since roughly a third of patients showed lesions that settled within 1.5 cm from the hippocampus, a sharp dose gradient would have been most important. HS-TCI would have been an option for roughly half of all patients presenting with brain metastasis. Thus, HS-PCI and, if applicable, HS-TCI could be routinely offered as alternative treatment option to patients with or at risk for BM. Author Disclosure: S. Harth: None. L. Zheng: None. Y. Abo-Madyan: None. F. Wenz: None. F.A. Giordano: None.

Published
2013
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49. A Prospective Study of Cerebral, Frontal Lobe, and Temporal Lobe Volume and Neuropsychologic Performance in Children With Primary Brain Tumors Treated With Cranial Radiation

Author

K.J. Redmond, Moody D. Wharam, Harold Agbahiwe, Kenneth J. Cohen, Doris D. M. Lin, Stephanie A. Terezakis, Todd McNutt, Alena Horská, and M. Mahone

Subjects
Cancer Research, medicine.medical_specialty, Radiation, business.industry, Cranial radiation, Temporal lobe, Oncology, Frontal lobe, Anesthesia, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, Primary Brain Tumors, business, Prospective cohort study, Volume (compression)
Published
2012
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