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Objective: To analyze the possible features of the blood lipid parameters of women in pre-retirement and retirement age. Materials and methods. We used materials of the two major international projects – «MONICA» and «HAPIEE». According to the protocol of these projects a representative sample of the Novosibirsk population have been surveyed. The analysis included data of 6092 women aged 45–64 years. Results. Levels of TC, nonHDL, LDL in women aged 45–54 years were slightly lower (an average – 10 %) than in the 55–64 years, but the frequency of hypercholesterolemia of LDL was high. Similar characteristics were obtained for the values of the so-called «atherogenic coefficient». Conclusion. «Pro-atherogenic» potential of blood lipid profile in women in pre-retirement and the retirement age is significant. In this connection, it is advisable to wider use lipid-lowering medicaments for women 45–54 years in order to reduce the risk of cardiovascular morbidity and mortality.

Objective was to study the levels and the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and proprotein convertase subtilisin/kexin type 9 (PCSK9), their relationship with other lipid parameters in patients with familial hypercholesterolemia (FH) in Russia. Material and methods. The study involved 47 patients (11 males) observed in the Scientific-clinical center of lipidology of Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics of SB RAS with diagnosis of «possible» or «definite» FH according to the criteria of The Simon Broome Register Group and «probable» or «definite» FH according to the Dutch Lipid Clinic Network Criteria. Patient age was 49.13 ± 12.67 years (mean ± SD); 50.00 [40.00; 59.00] years (median [lower quartile; upper quartile]). Lp-PLA2 and PCSK9 content was determined by enzyme-linked immunosorbent assay using a test systems «Human Proprotein Convertase 9/PCSK9 Immunoassay» («R&D Systems», USA) and «ELISA Kit for Phospholipase A2 Group VII (LpPLA2)» («Cloud-Clone Corp.», USA). Results. Lp-PLA2 level was 73,69 [64,99; 106,53] ng/ ml, PCSK9 – 352,16 [272,94; 416,79] ng/ml. There was a trend to moderate positive correlation between Lp-PLA2 and PCSK9 content (r = 0.614; p = 0.059), the statistical significance value was borderline due to the small number surveyed. Males showed a strong positive correlation of LP-FLA2 concentration with age (r = 0.746; p = 0.008), partial – with triglyceride (TG) content (r = 0.793; p = 0.019). A strong positive correlation of PCSK9 level with apolipoprotein B / apolipoprotein A ratio (r = 0.702; p = 0.007) and a weak positive correlation with TG concentration (r = 0.330; p = 0.033) were shown in the general group. Moderate positive correlation of PCSK9 content with age (r = 0.660; p = 0.038), a strong negative correlation with total cholesterol (r = –0.815; p = 0.004), low-density lipoprotein cholesterol (r = –0.828; p = 0.006) and non-high-density lipoprotein cholesterol (r = –0.851, p = 0.002) concentration were shown. Women with TG level

The aim of the work is to develop a new atherogenic coefficient as a personalized method for assessing cardiovascular risk in patients with dyslipidemia. Materials and methods. The subject of the study was a sample of men and women ( n = 100 people) with lipid metabolism disorders aged 50-70 years (mean age 58.7 ± 3.2 years) without documented cardiovascular pathology, diabetes mellitus, hereditary dyslipidemia. As a result of the research, a new CA was created and tested, including additional non-lipid risk factors, which was calculated using the formula: risk SCOREЧ(non-HDL-C/HDL-C). Results and discussion. Positive correlation of coefficient values with conventional factors of cardiovascular risk: age, levels of TC and LDL cholesterol, systolic blood pressure, lipid coefficient of atherogenicity, and estimated risk for SCORE, the latter being the strongest. Negative, reliable correlation of the new CA was found with the female sex of patients. Important for clinical practice is the fact that it does not require invasive intervention and significant time and material costs for an additional examination.

Familial hypercholesterolemia (FH) is one of the most common congenital metabolic disorders. Cascade genetic screening used for diagnostic of patients with FH. Aim of study is to explore the awareness of FH patients of the problem of familial hypercholesterolemia and conduct a pilot study of patients with FH using the principle of a cascade genetic screening. The study was performed in patients with a clinical diagnosis of “definite” FH. The study was approved ethics committee. Target was selected for high-throughput sequencing (GS Junior, Roche). Participation in the survey was voluntary and anonymous. An analysis of the responses to the questions provided data on the lack of awareness of patients with the FH about the problem. Certain mutations in this study and LDLR gene polymorphisms confirmed genetic heterogeneity of the spectrum of structural modifications of LDL receptor gene in patients with FH.

Aim. To carry out the population analysis of blood lipid profile trends during the period from 1985 to 2005 in Novosibirsk population.Material and methods. The study was carried out based on the databases of two large international epidemiological projects done in Novosibirsk, WHO “MONIСA” and “HAPIEЕ”. The representative samples from nonorganized population of Novosibirsk were tested in compliance with protocol of the projects. The analysis included data of 10272 people aged from 45 to 64 years; among them 4783 were men and 5489 — women.Results. Blood TC, non-HDL–C and LDL–С levels from the citizens of Novosibirsk aged 45–64 were significantly lower in the year 1995: 5,50±0,03 mM/l, 4,07±0,03 and 3,48±0,03 mM/l, respectively. By 2005 these values increased significantly and became higher than those initial in 1985. For women 20-year changes in TC, non-HDL–C and LDL–С levels are more prominent than for men. Trends of blood triglyceride levels are analogous to the changes of the indexes described above: average levels were the lowest in 1995 and the highest — in 2005. During a twenty years period the gradual statistically significant increase of blood HDL–C concentrations was noted: in 1985 its concentration was 1,29±0,01 mM/l, in 1995–1,42±0,01 mM/l (p

Aim. To study potential specific features of blood lipid profile in elderly indigenous and non-indigenous Yakutsk City residents, as well as in elderly Caucasian residents of Novosibirsk City.Material and methods. The representative sample of the non-institutionalised Yakutsk City population aged 60–69 years (main group, MG) included 159 people (69 men and 90 women; 41% of indigenous (Yakut) ethnicity and 59% of Caucasian ethnicity). The comparison group (CG) included 3949 Novosibirsk City residents who were participating in the international HAPIEE study (1834 men and 2115 women; 96% of Caucasian ethnicity).Results. The age-standardised blood lipid levels were similar in indigenous and non-indigenous Yakutsk City residents. The mean levels of total cholesterol (TCH) were 5,9 mmol/l in the whole sample, 5,8 mmol/l in men, and 6,1% mmol/l in women. In Yakut participants, these figures were 5,8, 5,7, and 5,9 mmol/l, respectively, while in Russian participants, they were slightly higher (6,0, 5,8, and 6,2 mmol/l, respectively). The levels of non-high density and low density lipoprotein cholesterol (nonHDL CH, LDL–CH) demonstrated similar gender and ethnic features. In non-indigenous Yakutsk City residents, the levels of TCH, LDL–CH, and high-density lipoprotein cholesterol (HDL–CH) were significantly lower than those in Novosibirsk City residents: 6,0 vs. 6,44 mmol/l for TCH (p

Dyslipidemia is one of the leading risk factors for atherosclerosis-associated cardiovascular disease, along with hypertension and smoking. Not only non-drug measures have great importance in the correction of this risk factor, but also cholesterol-lowering medicines. Now the statins are recognized as the most effective and safe. However, its effect of the maximum dose is insufficient or accompanied by side effects in some patients. Currently, several new classes of drugs have tested in clinical trials: cholesterol ester transfer protein inhibitors, blockers of apoprotein B synthesis, analogue of thyroid hormones; immunological intervention ways are developed, by monoclonal antibodies in particular.

Purpose: to analyze population values of the main blood lipid parameters of Novosibirsk inhabitants depending on sex and age. Materials and methods. The materials of the two large international projects called MONIСA and HAPIEЕ was used. According to these projects protocols, representative samples of unorganized population of Novosibirsk were studied. The analysis included data of 11,537 people aged 45-64, 5,445 men and 6,092 women among them. Results. Persons of both sex aged 45-64 had mean values of total cholesterol (TC), non-high density lipoproteins cholesterol (Ch-non-HDL), low density lipoproteins cholesterol (Ch-LDL) of serum equal to 6.05; 4.57; 3.93 mmol/l, respectively. Women aged 45–64 had the above blood parameters higher than men of the same age. Both men and women of 45–54 had higher blood TC, Ch-non-HDL, Ch-LDL levels than the ones aged 55–64, although women had more significant age dependent dynamics of the above blood lipid parameters than men. Blood triglycerides level in women was lower in 45–54 age group than in 55–64 decade; no differences were detected in men of these age groups. Blood triglycerides content in men aged 45–54 was higher, and in 55–64 age group it was lower than in women of the corresponding age. The same data was also received for atherogenic indexes (AI). Conclusion. Mean values of blood TC, Ch-non-HDL, Ch-LDL in population of Novosibirsk aged 45-64 exceed the optimal ones. Values of the above blood lipid parameters are higher in women than in men, and are also higher in senior age group compared to junior one. Whereby age dependent dynamics of atherogenic fractions in women aged 45-64 is more demonstrative than in men. AI in men of 45–54 age group is higher, and in 55–64 age group it is lower than in women of the same age.