1,694 results on '"K. Tsuda"'
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2. Abrupt reduction of the critical temperature difference of a thermoacoustic engine by adding water
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K. Tsuda and Y. Ueda
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Physics ,QC1-999 - Abstract
The critical temperature difference (ΔTcri) that causes a thermoacoustic spontaneous oscillation is reduced by the presence of water in the working fluid of a thermoacoustic engine. This letter introduces the effects of two design parameters on the reduction of ΔTcri: one is the mass of water added as the working fluid and the other is the characteristic length of the stack, which is the heart of a thermoacoustic engine. The experimental results show that when the mass of added water exceeds the threshold value, ΔTcri decreases abruptly; however, the decreased ΔTcri changes slightly with further increase in the added mass. Moreover, the characteristic length of the stack was found to have little effect on ΔTcri when water is added. These results provide a design guide for a thermoacoustic engine that includes water as the working fluid.
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- 2015
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3. Soft- and Hard-Error Radiation Reliability of 228 KB $3\mathrm{T}+1\mathrm{C}$ Oxide Semiconductor Memory.
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H. Takahashi, Y. Okamoto, Toshiki Hamada, Yusuke Komura, S. Watanabe, K. Tsuda, H. Sawai, Takanori Matsuzaki, Yoshinori Ando, Tatsuya Onuki, Hitoshi Kunitake, Shunpei Yamazaki, D. Kobayashi, A. Ikuta, Takahiro Makino, and Takeshi Ohshima
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- 2023
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4. Dynamic rupture simulations based on depth-dependent stress accumulation
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H Aochi and K Tsuda
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Geophysics ,Geochemistry and Petrology - Abstract
SUMMARY The depth variation in earthquake rupture behaviour is important for quantitative seismic hazard analysis. We discussed how to set up the initial stress on a fault before an earthquake based on the Mohr–Coulomb criterion considering depth variation. One can assume that the stress is uniformly loaded without exceeding the Coulomb criterion at any depth (stress-constrained condition); however, this implicitly induces a discontinuity of strain in a 1-D layered Earth model. We alternatively assumed that the strain in an upper layer does not exceed that in a lower layer (strain-constrained condition). We numerically demonstrated the dynamic rupture process through 3-D numerical simulations, particularly for the 2019 Mw 4.9 Le Teil (France) earthquake, showing a very shallow ruptured area with ground surface displacement. The rupture extent and seismogenic depth can be controlled by a limited layer at depth, which is favourably loaded in advance. The lateral extension of the rupture propagation at this layer is necessary to trigger the above layer but not enough to trigger the layers below. The depth variation of stress loading before an earthquake would be important for assessing the rupture size of moderate (magnitude 5–6) crustal earthquakes in particular.
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- 2022
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5. Effect of coordinator-based osteoporosis intervention on quality of life in patients with fragility fractures: a prospective randomized trial
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R. Okuda, M. Osaki, Y. Saeki, T. Okano, K. Tsuda, T. Nakamura, Y. Morio, H. Nagashima, and H. Hagino
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Endocrinology, Diabetes and Metabolism - Published
- 2022
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6. A c-axis aligned crystalline IGZO FET and a 0.06-μm2 HfO2-based Capacitor 1T1C FeRAM with High Voltage Tolerance and 10-ns Write Time
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M. Endo, S. Numata, K. Ohshima, Y. Egi, F. Isaka, T. Ohno, S. Tezuka, T. Hamada, K. Furutani, K. Tsuda, T. Matsuzaki, T. Onuki, T. Murakawa, H. Kunitake, M. Kobayashi, and S. Yamazaki
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- 2022
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7. Efficiency of coordinator-based osteoporosis intervention in fragility fracture patients: a prospective randomized trial
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Mari Osaki, T. Okano, Reiko Okuda, T. Nakamura, H. Hagino, K. Tsuda, Y. Morio, Hideki Nagashima, and Y. Saeki
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Male ,0301 basic medicine ,medicine.medical_specialty ,Pediatrics ,Bone density ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Psychological intervention ,Secondary fracture prevention ,030209 endocrinology & metabolism ,Bone density assessment ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Bone Density ,law ,Intervention (counseling) ,Internal medicine ,Secondary Prevention ,medicine ,Humans ,Prospective Studies ,Anti-osteoporosis treatment ,Fragility fracture ,Bone Density Conservation Agents ,business.industry ,Middle Aged ,medicine.disease ,Rheumatology ,Orthopedic surgery ,Fracture liaison service ,Original Article ,Female ,030101 anatomy & morphology ,Fall rate ,business ,Osteoporotic Fractures - Abstract
Summary We examined the effectiveness of coordinators’ interventions to prevent secondary fractures in patients with fragility fractures. These coordinator-based interventions improved bone density assessment implementation and treatment rates, and enhanced treatment persistence rates in the early stages following fractures. Introduction This study aimed to determine the efficiency of coordinator-based osteoporosis intervention in fragility fracture patients during a 2-year period. Methods A prospective intervention randomized control study was conducted at seven medical facilities from January 2015 to March 2017. Postmenopausal women and men over 50 years old with fragility fractures were randomly divided into the coordinator intervention (LI; 70 patients) and without intervention (non-LI; 71 patients) groups. The osteoporosis treatment rate, osteoporosis treatment persistence rate, fall rate, fracture incidence rate, and bone density measurement rate 3 months, 6 months, 1 year, and 2 years after registration were compared between the two groups. Non-parametric tests were used to analyze data at each inspection period. Results The osteoporosis treatment initiation rate was significantly higher in the LI group than in the non-LI group (85.7% vs. 71.8%; p = 0.04). The LI group had significantly higher bone density assessment implementation rates than the non-LI group at the time of registration (90.0% vs. 69.0%; p = 0.00) and 6 months after registration (50.0% vs. 29.6%; p = 0.01), but not 1 or 2 years after registration. In addition, no significant differences in fall or fracture incidence rates were found between the two groups. Conclusion The coordinator-based interventions for fragility fractures improved bone density assessment implementation and treatment rates and enhanced treatment persistence rates in the early stages following bone fractures. The findings suggest that liaison intervention may help both fracture and osteoporosis physicians for the evaluation of osteoporosis and initiation and continuation of osteoporosis medication.
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- 2021
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8. Epithelial layer unjamming shifts energy metabolism toward glycolysis
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Scott T. Weiss, Darren Roblyer, James P. Butler, Muhammad H. Zaman, Stephan A. Koehler, Jennifer A. Mitchel, Stephen J. DeCamp, Nicolas Chiu Ogassavara, Margherita De Marzio, Chan Young Park, John T. Giblin, Jacopo Ferruzzi, Ayşe Kılıç, Jeffrey J. Fredberg, and Victor M. K. Tsuda
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0301 basic medicine ,Leading edge ,Cell ,lcsh:Medicine ,Emergence ,02 engineering and technology ,Bioenergetics ,Cellular imaging ,Article ,Epithelium ,Madin Darby Canine Kidney Cells ,03 medical and health sciences ,Dogs ,Image processing ,Cell Movement ,medicine ,Animals ,Tissue engineering ,Cell migration ,Glycolysis ,lcsh:Science ,Membrane Potential, Mitochondrial ,Membrane potential ,Multidisciplinary ,Chemistry ,Glasses ,lcsh:R ,Motility ,NAD ,021001 nanoscience & nanotechnology ,Metabolism ,Glucose ,030104 developmental biology ,medicine.anatomical_structure ,Metabolic pathways ,Cytoplasm ,Biophysics ,lcsh:Q ,Energy Metabolism ,0210 nano-technology ,Wound healing ,Biological physics ,Oxidation-Reduction - Abstract
In development of an embryo, healing of a wound, or progression of a carcinoma, a requisite event is collective epithelial cellular migration. For example, cells at the advancing front of a wound edge tend to migrate collectively, elongate substantially, and exert tractions more forcefully compared with cells many ranks behind. With regards to energy metabolism, striking spatial gradients have recently been reported in the wounded epithelium, as well as in the tumor, but within the wounded cell layer little is known about the link between mechanical events and underlying energy metabolism. Using the advancing confluent monolayer of MDCKII cells as a model system, here we report at single cell resolution the evolving spatiotemporal fields of cell migration speeds, cell shapes, and traction forces measured simultaneously with fields of multiple indices of cellular energy metabolism. Compared with the epithelial layer that is unwounded, which is non-migratory, solid-like and jammed, the leading edge of the advancing cell layer is shown to become progressively more migratory, fluid-like, and unjammed. In doing so the cytoplasmic redox ratio becomes progressively smaller, the NADH lifetime becomes progressively shorter, and the mitochondrial membrane potential and glucose uptake become progressively larger. These observations indicate that a metabolic shift toward glycolysis accompanies collective cellular migration but show, further, that this shift occurs throughout the cell layer, even in regions where associated changes in cell shapes, traction forces, and migration velocities have yet to penetrate. In characterizing the wound healing process these morphological, mechanical, and metabolic observations, taken on a cell-by-cell basis, comprise the most comprehensive set of biophysical data yet reported. Together, these data suggest the novel hypothesis that the unjammed phase evolved to accommodate fluid-like migratory dynamics during episodes of tissue wound healing, development, and plasticity, but is more energetically expensive compared with the jammed phase, which evolved to maintain a solid-like non-migratory state that is more energetically economical.
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- 2020
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9. Physics-Based Compact Model for CAAC In-Ga-Zn Oxide Multi-Gate FETs with Free Shape of Fin
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M. Watanabe, S. Mijalkovic, B. Tudor, K. Tsuda, H. Kunitake, and S. Yamazaki
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- 2022
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10. Nickel-Aluminium Bronze Cast into 3D Sand Printed Moulds: Kappa II Phase and Segregation of Phosphorus
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S. Nusen, T. Chairuangsri, D. Morikawa, K. Tsuda, and J.T.H. Pearce
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General Materials Science - Published
- 2022
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11. Subjective well‐being among rheumatoid arthritis patients
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Jun Saegusa, Y. Ueda, G. Kageyama, Keisuke Nishimura, K. Akashi, Akio Morinobu, Akira Onishi, Takaichi Okano, S. Sendo, I. Naka, and K. Tsuda
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Male ,Multivariate analysis ,Health Status ,media_common.quotation_subject ,Arthritis, Rheumatoid ,Japan ,Rheumatology ,Quality of life ,Surveys and Questionnaires ,Adaptation, Psychological ,Humans ,Medicine ,Subjective well-being ,Social Behavior ,Depression (differential diagnoses) ,Retrospective Studies ,media_common ,Marital Status ,business.industry ,Middle Aged ,Cross-Sectional Studies ,Socioeconomic Factors ,Quality of Life ,Happiness ,Marital status ,Anxiety ,Household income ,Female ,medicine.symptom ,business ,Social Welfare ,Follow-Up Studies ,Clinical psychology - Abstract
Aim Subjective well-being (SWB) is a psychological construct that is synonymous with happiness. Many variables including age, sex, income, employment, and marital status are related to SWB. Health is also an important determinant of SWB that can be adversely affected in patients with chronic conditions such as rheumatoid arthritis (RA). In this study, we evaluate the SWB of RA patients and compare it with that of healthy controls. Methods We obtained the original dataset from the "Quality of Life Survey, 2013", which was conducted by the Economic and Social Research Institute, Cabinet Office, Government of Japan. In this survey, SWB was determined by asking participants to rate their happiness between 0 (very unhappy) and 10 (very happy). The survey also included a 56-point questionnaire regarding well-being-related variables. This questionnaire was administered to RA patients recruited from Kobe University Hospital, and clinical and treatment data were simultaneously collected. Results Multivariate analysis revealed that RA patients with high or moderate disease activity had SWB scores that were similar to those of controls. However, the SWB scores of RA patients in remission or with low disease activity were higher than those of controls (P = .013). SWB was associated with household income, self-assessment of living costs, self-assessment of health, depression/ anxiety, and social connection. Conclusions For RA patients, achieving the therapeutic target can result in better SWB than that of healthy controls. Financial status, self-assessment of health, psychological stress, and social network are also important determinants for the SWB of RA patients.
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- 2019
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12. Effect of coordinator-based osteoporosis intervention on quality of life in patients with fragility fractures: a prospective randomized trial
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R, Okuda, M, Osaki, Y, Saeki, T, Okano, K, Tsuda, T, Nakamura, Y, Morio, H, Nagashima, and H, Hagino
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Fractures, Bone ,Quality of Life ,Humans ,Osteoporosis ,Pain ,Prospective Studies ,Osteoporotic Fractures - Abstract
We examined the effects of the coordinator-based intervention on quality of life (QOL) in the aftermath of a fragility fracture, as well as factors predictive of post-fracture QOL. The coordinator-based interventions mitigated the decrease in QOL. Secondary fracture after primary fracture, however, was a significant predictor of lower QOL.This study aimed to determine the effects of the coordinator-based intervention on QOL in the aftermath of a fragility fracture, as well as factors predictive of post-fracture QOL, in an Asian population.Patients with new fractures in the intervention group received the coordinator-based intervention by a designated nurse certified as a coordinator, within 3 months of injury. QOL was evaluated using the Japanese version of the EuroQol 5 Dimension 5 Level (EQ-5D-5L) scale before the fracture (through patient recollections) and at 0.5, 1, and 2 years after the primary fracture.Data for 141 patients were analyzed: 70 in the liaison intervention (LI) group and 71 in the non-LI group. Significant intervention effects on QOL were observed at 6 months after the fracture; the QOL score was 0.079 points higher in the LI group than in the non-LI group (p=0.019). Further, the LI group reported significantly less pain/discomfort at 2 years after the fracture, compared to the non-LI group (p=0.037). In addition, secondary fractures were found to significantly prevent improvement and maintenance of QOL during the recovery period (p=0.015).Short-term intervention effects were observable 6 months after the primary fracture, with the LI group mitigated the decrease in QOL. Few patients in the LI group reported pain/discomfort 2 years after the fracture, but there is uncertainty regarding its clinical significance. Secondary fracture after initial injury was a significant predictor of lower QOL after a fracture.
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- 2021
13. Multiphoton fluorescence lifetime imaging of NADH reveals spatio-temporal patterns in cell metabolism during collective migration
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Stephen J. DeCamp, Victor M. K. Tsuda, Muhammad H. Zaman, Jacopo Ferruzzi, Jeffrey J. Fredberg, and Darren Roblyer
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Membrane potential ,Redox ratio ,Fluorescence-lifetime imaging microscopy ,Cytoplasm ,Chemistry ,In vitro system ,Collective cell migration ,Biophysics ,Metabolism ,Collective migration - Abstract
Fluorescence lifetime imaging (FLIM) is a powerful tool to quantify local changes in cell metabolism without loss of spatial resolution. Here, we adopted FLIM to characterize spatio-temporal metabolic changes occurring during collective cell migration. Using an established in vitro system, we measured biomechanical and metabolic changes during migration of epithelial cell monolayers. We developed a custom image analysis pipeline that combines machine learning segmentation and curve fitting analysis to analyze FLIM data. Our findings – which were validated via separate measurements of cytoplasmic redox ratio, glucose uptake, and mitochondrial membrane potential – are consistent with a glycolytic shift during collective cell migration.
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- 2021
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14. Low Z gas mixing effects of Ar and Xe multicharged ions in electron cyclotron resonance ion source
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K Tsuda, W Kubo, S Harisaki, M Anan, K Sato, I Owada, T Maenaka, and Y Kato
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History ,Physics::Plasma Physics ,Physics::Space Physics ,Computer Science Applications ,Education - Abstract
An electron cyclotron resonance (ECR) ion source (ECRIS) has wide applications such as cancer therapy and material synthesis. We have constructed a single ECRIS capable of producing various ions with low to high mass/charge ratio, and have been conducting various experiments. We focus on the efficient production of multicharged ions and aim to increase the yield of multicharged ions by new effects of electromagnetic waves in ECRIS. We investigated the possibility of selective heating to low Z ions under low Z gas mixing. Therefore, as a preliminary step of these experiments, the low Z gas mixing effect with rare gases are investigated. The optimum mixing ratio of the main gas Ar and the low Z gas He was investigated by varying the mixing ratio. The Ar multicharged ion beam current, impurity fraction and plasma parameters were measured. As a result, it was confirmed that the Ar multicharged ion yield was sufficient reproducibly increased by mixing He gas into Ar plasma. In addition, this from the measured plasma parameters is not an effect of the plasma parameters, but maybe a cooling effect.
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- 2022
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15. Low-voltage extraction characteristics of ion beams and space potential measurements on ECRIS
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I Owada, W Kubo, S Harisaki, K Tsuda, K Sato, M Anan, T Maenaka, and Y Kato
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History ,Physics::Plasma Physics ,Computer Science Applications ,Education - Abstract
We have been using an electron cyclotron resonance ion source (ECRIS) for ion beam production, and it is desirable to construct a universal ECRIS that can produce ions with a wide range of mass/charge ratios, e.g. from several to several thousand. We investigated the characteristics of ions with high mass/charge ratios, e.g., iron endohedral fullerenes production, which requires low voltage beam extraction. We investigated the characteristics of the ion beam extraction at low extraction voltage. It is found that the beam current almost obeyed the Child-Langmuir law for various ion species. The space potential of the plasma in the ion source can be obtained from the relation between the extraction voltage and the square of the magnetic field strength of the dipole magnet. It is found that space potential values are larger with large charge state of ions, in low gas pressure condition and in high microwave incident power. At the same time, the plasma space potential was measured by using a Langmuir probe and compared with the ion beam method. It is found that same trend is confirmed with probe method.
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- 2022
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16. Optimized deceleration characteristics of multicharged ion beams from electron cyclotron resonance ion source
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K Sato, S Harisaki, W Kubo, I Owada, K Tsuda, M Anan, T Maenaka, and Y Kato
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History ,Computer Science Applications ,Education - Abstract
At present it is necessary the satellite lifetime 10-15 years for operating in space. Xenon is used as fuel for ion engines of satellites. There are problems of accumulated damages at irradiation and sputtering by low energy Xe ion from the engine. It is required to construct database of sputtering yield of ion beams in the low energy region from a hundred eV to 1keV. We are trying to investigate experimentally sputtering yield on satellite component by irradiating the low energy Xe q+ ion beams. We use the electron cyclotron resonance ion source (ECRIS) in the irradiation experiments. We decelerate the beam energy to several hundred eV after extraction at high voltage 10kV. It is found we cannot neglect the contribution of the space potential of the plasma in the ECRIS of several tens eV. We measured the plasma parameters and ion beam deceleration characteristics in operating conditions on ECRIS. As the results, it was found in operating ECRIS condition of low charge state ion being dominant that the space potential of the ECRIS has an effect of 10∼20% at the beam energy at about 100eV in conducting irradiation experiments on satellite component materials.
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- 2022
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17. Cutoff limitation of left-hand polarization wave and candidates for further enhanced producing multicharged ions on ECRIS
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Y Kato, W Kubo, S Harisaki, M Anan, K Tsuda, K Sato, I Owada, and T Maenaka
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History ,Physics::Plasma Physics ,Computer Science Applications ,Education - Abstract
Based on experimentally obtained plasma parameters in an electron cyclotron resonance (ECR) ion source (ECRIS) and theoretical considerations, it is turned out the essential factor that is currently presumed to define the increase in multicharged ion current in ECRIS is not simply the density limit of ordinary wave and right-hand cutoffs, but is also higher density one of left-hand cutoff. There are two response guidelines that can be considered to make it possible to overcome limitations, except for the conventional simply increasing the frequency and the magnetic field strength. One is advanced high-frequency resonance, i.e., upper-hybrid resonance (UHR), which is conversion from electromagnetic to electrostatic wave essentially without cutoff. The others are due to the introduction of lower frequency waves than ECR’s one, which has no density limit in a more essential sense. The latter is the introduction of lower-hybrid resonance (LHR) or ion cyclotron resonance (ICR). We will describe experimentally obtained plasma parameters, and will discuss these candidate applications.
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- 2022
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18. Energy Metabolism and Unjamming
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Jennifer A. Mitchel, Stephen J. DeCamp, James P. Butler, Stephan A. Koehler, Nicolas Chiu Ogassavara, Victor M. K. Tsuda, and Jeffrey J. Fredberg
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Chemistry ,Biophysics ,Energy metabolism - Published
- 2020
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19. A 40-GHz D-type flip-flop using AlGaAs/GaAs HBT's.
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Y. Kuriyama, T. Sugiyama, S. Hongo, J. Akagi, K. Tsuda, N. Iizuka, and M. Obara
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- 1995
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20. A Long Term Study to Feed Boars and Sows on Forage Rice
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H. Yamashita, T. Inenaga, S. Ieiri, and K. Tsuda
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,Animal science ,Long term learning ,0402 animal and dairy science ,Forage ,04 agricultural and veterinary sciences ,Biology ,040201 dairy & animal science - Published
- 2017
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21. Characteristics of Scaled CAAC-IGZO FET and Its Application to LSI
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K. Kato, H. Kunitake, T. Onuki, K. Tsuda, S. Ohshita, D. Shimada, Y. Yanagisawa, T. Murakawa, T. Atsumi, and S. Yamazaki
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Materials science ,business.industry ,Optoelectronics ,business - Published
- 2019
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22. Mechanism of Threshold Voltage Control by Back Gates in CAAC-IGZO FETs
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T. Takeuchi, K. Tsuda, K. Tochibayashi, T. Atsumi, R. Honda, S. Yamazaki, and K. Kato
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Materials science ,business.industry ,Optoelectronics ,business ,Mechanism (sociology) ,Threshold voltage - Published
- 2018
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23. Egg Yolk Antibody Igy and Its Application
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H. Hatta, M. Ozeki, and K. Tsuda
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- 2018
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24. Metabolomics analysis of saliva from patients with primary Sjögren's syndrome
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Akio Morinobu, K. Tsuda, Shino Tanaka, S. Sendo, S. Takahashi, Jun Saegusa, Yasuhiro Irino, and G. Kageyama
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Adult ,Saliva ,medicine.medical_specialty ,Metabolite ,Immunology ,Physiology ,Biology ,Gas Chromatography-Mass Spectrometry ,chemistry.chemical_compound ,Metabolomics ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Principal Component Analysis ,Salivary gland ,Translational ,Significant difference ,Middle Aged ,stomatognathic diseases ,Sjogren's Syndrome ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Potential biomarkers ,Metabolome ,Uric acid ,Female ,Sjogren s - Abstract
Summary The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sjögren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this disease. We obtained salivary samples from 12 female pSS patients (mean age 44.2 ± 13.01) and 21 age-matched female HCs. The metabolite profiles of saliva were analysed by gas chromatography-mass spectrometry. The total metabolite levels in each of the samples were calculated and compared across the study participants. A total of 88 metabolites were detected across the study samples, 41 of which were observed at reduced levels in the samples frompSS patients. Principal component analysis (PCA) revealed a loss in salivary metabolite diversity in the pSS patient samples compared to the HC samples. The reduced presence of glycine, tyrosine, uric acid and fucose, which may reflect salivary gland destruction due to chronic sialoadenitis, contributed to the loss of diversity. Comparative PCA of the pSS patients revealed the presence of two subpopulations based on their metabolite profiles, and these two subpopulations showed a significant difference in the prevalence of major salivary glanditis (P = 0·014). In this study, we found that the salivary metabolite profile of pSS patients was less diverse than that of HCs and that the metabolite profiles in pSS patients were affected by the presence of major salivary glanditis.
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- 2015
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25. OP0152 A longitudinal study of the effects of disease activity on renal function in patients with rheumatoid arthritis utilizing linear mixed effect models - answer cohort study
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Yonsu Son, Daisuke Waki, Jun Saegusa, K. Akashi, S. Takahashi, Y. Ueda, Kosuke Ebina, Akio Morinobu, I. Naka, Toshio Hirano, Hideki Amuro, Shuzo Yoshida, Koji Nagai, K. Tsuda, Wataru Yamamoto, H. Yamada, Moritoshi Furu, T. Okano, Yoshinori Kogata, Takanori Fujimura, Ryota Hara, Motomu Hashimoto, Masaki Katayama, Akira Onishi, S. Sendo, and Y. Ichise
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Nephrology ,medicine.medical_specialty ,education.field_of_study ,Tofacitinib ,business.industry ,Population ,Renal function ,medicine.disease ,Surgery ,Nephrotoxicity ,Internal medicine ,Rheumatoid arthritis ,medicine ,business ,education ,Kidney disease ,Cohort study - Abstract
Background Patients with RA have higher risk of developing chronic kidney disease compared to the general population. Although some causes of renal impairment in RA include nephrotoxic medications, amyloidosis, and glomerulonephritis, specific causes are not determined among most patients with RA. While experimental researches showed inflammatory process per se might also contribute to renal dysfunction, the results of previous clinical studies that assessed the effects of disease activity or C-reactive protein on renal function were inconsistent. This inconsistency might be attributable to their cross-sectional design, small sample size, and assessment of association between only baseline characteristics and renal outcomes without consideration for the fact that disease activity and medications had changed over time. Objectives To identify the effects of disease activity on renal function in RA in a multi-center cohort study. Methods RA patients with a sampling interval of less than 150 days were enrolled because wide sampling intervals could not take into consideration changes in disease activity and medications during their follow-up. An estimated glomerular filtration rate (eGFR) was calculated using an equation approved by the Japanese Society of Nephrology and used as an outcome variable. Linear mixed effect models were used to evaluate the renal trajectories of patients. Time from baseline (months), disease activity, and their interaction were included as fixed effects while participant identification number and time from baseline were included as random factors. Age, sex, disease duration, RF, ACPA, NSAIDs, and DMARDs that were known as a cause of renal impairment, such as tacrolimus, iguratimod, and tofacitinib, were included as covariates. Results A total of 25661 samples (mean sampling interval: 2.0 months) from 2104 patients was included. Patients with lower DAS28-CRP had worse renal function at inclusion, but a significantly better longitudinal trajectory on eGFR (0.0079 ml/min/1.73m2 per month, P=0.025). Although all RA patients had naturally progressive renal impairment as they got older, patients who achieved remission or low disease activity had slower renal impairment rate of -0.068 ml/min/1.73m2 per month compared to patients with moderate or high disease activity (-0.084 ml/min/1.73m2 per month; P=0.037). These results were also similar using SDAI or CDAI. Conclusions Lower disease activity results in slower renal impairment. Because the effects of disease activity on renal function are mild, additional measures to protect renal function, such as avoiding nephrotoxic medications and treating cardiovascular risk factors are important. Disclosure of Interest None declared
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- 2017
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26. RT-PCR micromodule based on oligo(dT) microcolumn for micro total gene expression analysis system
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K. Hattori, K. Nakagawa, Satoshi Fujita, Kohei Kido, Satoru Ato, Satoshi Konishi, and K. Tsuda
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0301 basic medicine ,Messenger RNA ,Chemistry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Molecular biology ,Reverse transcription polymerase chain reaction ,03 medical and health sciences ,030104 developmental biology ,Real-time polymerase chain reaction ,Gene duplication ,Gene expression ,0210 nano-technology ,Oligo dt ,Gene ,Function (biology) - Abstract
In gene expression analysis, target genes are amplified by reverse transcription polymerase chain reaction (RT-PCR) with messenger RNA (mRNA). We previously reported a microfluidic device for mRNA isolation by the combination of a micromill and a microshredder. In this study, we report an RT-PCR micromodule that can operate simultaneously with above device. Gene amplification by RT-PCR requires mRNA purified from cell lysates and the temperature regulation during the reaction procedure. We designed an RT-PCR micromodule consisting of a microcolumn containing packed oligo(dT) microbeads and a temperature control system. The developed RT-PCR micromodule has a sufficient gene amplification function and can be applied to as a micro total gene expression analysis system.
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- 2017
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27. Concrete Filled Steel Tubular Structures
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K. Tsuda
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Materials science ,General Materials Science - Published
- 2014
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28. Six-month effectiveness of low-frequency repetitive transcranial magnetic stimulation and intensive occupational therapy in upper limb hemiparesis after stroke
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Y. Teramoto, M. Nakayama, R. Sasayama, K. Tsuda, A. Matsuda, and Yoshitada Sakai
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Occupational therapy ,medicine.medical_specialty ,Combination therapy ,business.industry ,medicine.medical_treatment ,Rehabilitation ,medicine.disease ,Transcranial magnetic stimulation ,medicine.anatomical_structure ,Hemiparesis ,Anesthesia ,medicine ,Paralysis ,Upper limb ,Orthopedics and Sports Medicine ,medicine.symptom ,business ,Adverse effect ,Stroke - Abstract
Introduction/Background There has been increasing recognition of combination therapy of low-frequency repetitive transcranial magnetic stimulation (rTMS) and intensive occupational therapy (OT) in upper limb hemiparesis. But few studies have reported on the long-term effect. We report the long-term effect of this therapy in upper limb paralysis in chronic stroke patients. Material and method Twenty-two patients with chronic hemiparesis, who received combination therapy of low-frequency rTMS and OT were enrolled (age: 55.4 ± 14.8 years; time after onset: 1522 ± 1332 days). Patients underwent 15 days therapy while Wolf Motor Function Test (WMFT) and Action Research Arm Test (ARAT) were recorded before, after, and 6-month after the therapy. Differences in scores were tested for statistical significance by using ANOVA and Tukey. Results All patients completed the therapy without any adverse effects. All of the score improved significantly between before and after the therapy (WMFT time: from 722 to 590 s, P Conclusion A combination therapy of low-frequency rTMS and OT enhances motor recovery of the upper limb paralysis in chronic stroke patients. These results suggest that the effect lasts for 6 months after the therapy. This is an area of ongoing research and further studies are needed.
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- 2018
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29. Output Power of Piezoelectric MEMS Vibration Energy Harvesters Under Random Oscillation
- Author
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S Murakami, T Yoshimura, M Aramaki, Y Kanaoka, K Tsuda, K Satoh, K Kanda, and N Fujimura
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History ,Computer Science Applications ,Education - Abstract
The output characteristics of MEMS piezoelectric vibration energy harvesters (PVEHs) under random oscillations are analysed. We fabricated cantilever-type MEMS-PVEHs using Pb(Zr,Ti)O3 films. The autocorrelation function of the transient displacement of the cantilever tip under random oscillations features a narrow-band random vibration. From the power spectral density (PSD) of the output voltage of the PVEHs, the resonance frequency decreases and the full-width at half-maximum increases with increasing vibration acceleration. By comparing output properties under various sinusoidal oscillations, nonlinear effects including the soft-spring effect and nonlinear damping effect clearly influence the output characteristics under random oscillations. The power generation is proportional to the square of the vibration acceleration even in the acceleration region where nonlinear effects become conspicuous.
- Published
- 2019
- Full Text
- View/download PDF
30. Prevention effect of material flow in the porous rocks by aquo-siloxane method
- Author
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Akira Sato, K. Habu, T. Yatsunami, Koichi Ikeda, T. Fukumitsu, and K. Tsuda
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010302 applied physics ,chemistry.chemical_compound ,Materials science ,0205 materials engineering ,chemistry ,Chemical engineering ,Siloxane ,0103 physical sciences ,02 engineering and technology ,Porosity ,01 natural sciences ,020501 mining & metallurgy ,Material flow - Published
- 2016
- Full Text
- View/download PDF
31. Analyses of static and dynamic behavior of coned disk springs: Effects of friction boundaries
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K. Tsuda, J. Tominaga, and Shingo Ozaki
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Materials science ,Deformation (mechanics) ,Series (mathematics) ,business.industry ,Systematic survey ,Mechanical Engineering ,Building and Construction ,Structural engineering ,Finite element method ,Damper ,Vibration ,Hysteresis ,Axial load ,business ,Civil and Structural Engineering - Abstract
In the present study, we perform a systematic survey of the effects of friction boundaries on the static deformation behavior of coned disc springs subjected to an axial load using the finite element method. Based on the equivalence of energies and friction law, a simplified method for predicting load–deflection curves is developed in which hysteresis due to friction at the edges is included. We then extend the proposed method to stacked springs in series and in parallel. The validity of the method is then verified by comparing the results obtained with the finite element analysis and experiments under various conditions. In addition, the dynamic characteristics of coned disc springs subjected to an axial forced vibration are studied using the proposed method. The effect of friction boundaries, i.e., frictional dampers, is investigated under several frictional conditions, forced vibration, and initial loads. It is shown that the present method can also be applied for examining the dynamic characteristics of coned disc springs.
- Published
- 2012
- Full Text
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32. Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study
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Hiroki Hayashi, Takashi Nakazawa, K. Tsuda, Akio Morinobu, Keisuke Nishimura, Takeshi Sugimoto, Yoshinori Kogata, Chiyo Kurimoto, Akira Onishi, Jun Saegusa, Go Tsuji, Shunichi Kumagai, G. Kageyama, Seiji Kawano, I. Naka, Kenta Misaki, and Daisuke Sugiyama
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cyclophosphamide ,Endpoint Determination ,Lupus nephritis ,Pharmacology ,Mycophenolate ,Gastroenterology ,Pharmacotherapy ,Asian People ,Japan ,Rheumatology ,Internal medicine ,medicine ,Humans ,Glucocorticoids ,Retrospective Studies ,business.industry ,Remission Induction ,Induction chemotherapy ,Retrospective cohort study ,Induction Chemotherapy ,Mycophenolic Acid ,Japanese population ,medicine.disease ,Hematologic Diseases ,Lupus Nephritis ,Injections, Intravenous ,cardiovascular system ,Drug Therapy, Combination ,Female ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Recent studies have shown that mycophenolate mofetil (MMF) is similar to intravenous cyclophosphamide (IVC) for the treatment of lupus nephritis (LN), but that treatment response may vary according to location and race/ethnicity. Moreover, no studies have been conducted to compare the efficacy of MMF with that of IVC for a Japanese population. We therefore conducted a retrospective study to clarify the efficacy and safety of MMF compared with that of IVC for induction therapy for active LN, classes III and IV, in a Japanese population of 21 patients, 11 of whom received MMF and 10 IVC.The primary endpoint was expressed as the percentage of responders, who in turn were defined as the patients who met complete or partial response criteria according to the European consensus statement. The secondary endpoints comprised the renal activity component and serological activity.The primary endpoint was achieved in nine (81.8 %) patients receiving MMF and in four (40.0 %) receiving IVC, with no significant difference between the two groups (p = 0.081), while there was also no significant difference between them in terms of secondary endpoints. However, the MMF group suffered significantly fewer hematologic toxic effects than the IVC group.MMF may be used as an alternative to IVC for inducing renal remission of LN in Japanese patients.
- Published
- 2012
- Full Text
- View/download PDF
33. Assessment of thrombin-induced platelet aggregation using an automatic coagulation analyzer
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M. Yoshida, S. Narumi, A. Kamata, Tatsunori Natori, K. Oura, K. Tsuda, Y. Ishigaku, Yasuo Terayama, and M. Simuzu
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Spectrum analyzer ,Thrombin ,Neurology ,Chemistry ,Induced platelet aggregation ,medicine ,Biophysics ,Coagulation (water treatment) ,Neurology (clinical) ,medicine.drug - Published
- 2017
- Full Text
- View/download PDF
34. Configuration of the virtual laboratory for fusion researches in Japan
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S. Takami, T. Yamamoto, S. Okamura, Seiji Ishiguro, K. Tsuda, Hideya Nakanishi, and Yoshio Nagayama
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Nuclear Energy and Engineering ,business.industry ,Computer science ,Mechanical Engineering ,Bandwidth (computing) ,Virtual Laboratory ,General Materials Science ,Throughput ,Telecommunications ,business ,Grid ,Supercomputer ,Civil and Structural Engineering - Abstract
A virtual laboratory system for nuclear fusion researches in Japan known as SNET run by the National Institute for Fusion Science has been in development for the past seven years. Twenty-one remote sites have participated in SNET, which reached a speed of 1 Gbps in April 2009. The SNET is a closed network system based on L2 and L3VPN provided by SINET3, which is a national academic network operated by the National Institute of Informatics. SNET has been successfully supporting the remote participation of various sizes and types of experimental equipments and has also been supporting the remote use of a supercomputer. In this paper, we describe the configuration of SNET, which is overcoming the challenges that arise in virtual laboratories; we mainly explain the remote participation in the experiment. Remarks about the remote participation regarding the ITER activity, massive data transfer, and GRID are also discussed. A data transfer experiment between Japan and France was performed, with the average throughput reaching 880 Mbps on 1 Gbps of bandwidth.
- Published
- 2010
- Full Text
- View/download PDF
35. Control, data acquisition, data analysis and remote participation in LHD
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J. Miyazawa, K. Tsuda, S. Sudo, S. Takami, Hideya Nakanishi, Ryuichi Sakamoto, Y. Nakamura, Shin Kubo, Tetsuo Seki, Maiko Yoshida, H. Funaba, Tsuguhiro Watanabe, Seiji Ishiguro, Atsushi Mase, T. Yamamoto, Takashi Mutoh, C. Iwata, M. Nonomura, S. Imazu, Shigeru Inagaki, Y. Ito, A. Komori, Y. Nagayama, M. Emoto, Mamoru Shoji, Mamoru Kojima, O. Motojima, M. Ohsuna, Toshiyuki Mito, Ritoku Horiuchi, Hirotaka Chikaraishi, and K. Saito
- Subjects
Computer science ,Fortran ,Mechanical Engineering ,Real-time computing ,Supercomputer ,Control room ,Storage area network ,Fibre Channel ,Data acquisition ,Nuclear Energy and Engineering ,Label switching ,Virtual Laboratory ,General Materials Science ,computer ,Civil and Structural Engineering ,computer.programming_language - Abstract
This paper presents the control, data acquisition, data analysis and remote participation facilities of the Large Helical Device (LHD), which is designed to confine the plasma in steady state. In LHD the plasma duration exceeds 3000 s by controlling the plasma position, the density and the ICRF heating. The “LABCOM” data acquisition system takes both the short-pulse and the steady-state data. A two-layer Mass Storage System with RAIDs and Blu-ray Disk jukeboxes in a storage area network has been developed to increase capacity of storage. The steady-state data can be monitored with a Web browser in real time. A high-level data analysis system with Web interfaces is being developed in order to provide easier usage of LHD data and large FORTRAN codes in a supercomputer. A virtual laboratory system for the Japanese fusion community has been developed with Multi-protocol Label Switching Virtual Private Network Technology. Collaborators at remote sites can join the LHD experiment or use the NIFS supercomputer system as if they were working in the LHD control room.
- Published
- 2008
- Full Text
- View/download PDF
36. Virtual laboratory for fusion research in Japan
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S. Takami, K. Tsuda, Seiji Ishiguro, Ritoku Horiuchi, T. Yamamoto, and Y. Nagayama
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Research program ,business.industry ,Computer science ,Mechanical Engineering ,Fusion power ,Supercomputer ,Control room ,Fiscal year ,Firewall (construction) ,Nuclear Energy and Engineering ,Virtual Laboratory ,Systems engineering ,General Materials Science ,The Internet ,business ,Civil and Structural Engineering - Abstract
A virtual laboratory system for nuclear fusion research in Japan has been developed using SuperSINET, which is a super high-speed network operated by National Institute of Informatics. Sixteen sites including major Japanese universities, Japan Atomic Energy Agency and National Institute for Fusion Science (NIFS) are mutually connected to SuperSINET with the speed of 1 Gbps by the end of 2006 fiscal year. Collaboration categories in this virtual laboratory are as follows: the large helical device (LHD) remote participation; the remote use of supercomputer system; and the all Japan ST (Spherical Tokamak) research program. This virtual laboratory is a closed network system, and is connected to the Internet through the NIFS firewall in order to keep higher security. Collaborators in a remote station can control their diagnostic devices at LHD and analyze the LHD data as they were at the LHD control room. Researchers in a remote station can use the supercomputer of NIFS in the same environment as NIFS. In this paper, we will describe detail of technologies and the present status of the virtual laboratory. Furthermore, the items that should be developed in the near future are also described.
- Published
- 2008
- Full Text
- View/download PDF
37. Deposition and wear resistance of Ti–B–N–C coatings on WC–Co cutting tools from alkoxide solutions by thermal plasma CVD
- Author
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Jiro Tsujino, Shiro Shimada, K. Tsuda, M. Takahashi, and Isao Yamazaki
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Materials science ,Metallurgy ,Composite number ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Chemical vapor deposition ,Condensed Matter Physics ,Microstructure ,Surfaces, Coatings and Films ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Alkoxide ,Materials Chemistry ,Thin film ,Boron ,Tin ,Titanium - Abstract
Double layered TiN/TiBC and composite TiBCN coatings were deposited on WC–Co cutting tools from titanium tetra-ethoxide (TTEO) and boron tri-ethoxide (BTEO) solutions at 800 °C for 20 min by chemical vapor deposition (CVD) in a thermal Ar/N 2 /H 2 plasma. The double layered coatings were deposited in Ar/N 2 /H 2 plasma for the first 10 min, followed by another 10 min deposition in Ar/H 2 plasma. The composite TiBCN coatings of various compositions were deposited from the mixed solutions of TTEO and BTEO at a 1:2 mole ratio by changing the N 2 flow rate. The crystalline phases of the coatings were identified by thin film X-ray diffraction. The surfaces and cross sections of the coatings were observed by SEM, revealing the microstructures and thickness of the coatings. The relative concentrations of Ti, N, B, bonded and free C, and O in the coatings were determined semi-quantitatively from the XPS peak areas. The composite TiBCN coatings deposited on WC–Co cutting tools exhibited superior flank and crater wear resistance compared with commercial TiN coatings.
- Published
- 2007
- Full Text
- View/download PDF
38. Genetic evidence of extensive introgression of short-tailed ground squirrel genes in a hybridization zone of Spermophilus major and S. erythrogenys, inferred from sequencing of the mtDNA cytochrome b gene
- Author
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V. P. Starikov, G. N. Chelomina, L. N. Spiridonova, K. Tsuda, and H. Yonekawa
- Subjects
Genetics ,Mitochondrial DNA ,biology ,Phylogenetic tree ,Genetic distance ,Cytochrome b ,Evolutionary biology ,Spermophilus ,Haplotype ,Introgression ,Subgenus ,biology.organism_classification - Abstract
We have completely sequenced the mtDNA cytochrome b gene of ground squirrels from the zone of overlapping ranges of Spermophilus major and S. erythrogenys in the Tobol-Ishim interfluve, which is a putative hybridization zone of these species. The results of the sequencing showed extensive introgression of mtDNA genes of the short-tailed ground squirrel S. e. brevicauda, whose haplotype had fully replaced the S. major haplotype. All of the ground squirrels from the Tobol-Ishim interfluve had a variant of the S. e. brevicauda mtDNA haplotype that was specific for this zone. On average, 119 substitutions (10.44%) were found between S. major from Ul'yanovsk oblast and S. e. brevicauda from the northern Kazakhstan, the mean genetic distance (D) between them being 0.115, which conforms to the corresponding parameters for the S. e. brevicauda-S. pygmaeus pair (122 substitutions, D = 0.118). Insignificant differences (seven substitutions, D = 0.043) were found between the S. major and S. pygmaeus haplotypes, which suggest that these species have similar mitochondrial haplotypes. Five to ten nucleotide substitutions (0.44–0.88%) were detected between the animals from the Tobol-Ishim interfluve and S. e. brevicauda. The mtDNA haplotype divergence D within the genus Spermophilus (ten species) for all codon positions ranged from 0.035 to 0.158. Phylogenetic reconstructions (MP, ML, and NJ trees) showed two well-differentiated clusters with high bootstrap support. However, there was different branching topology within the cluster and their species composition varied. The maximum likelihood tree, ML, differentiating the species into two subgenera, Citellus and Colobotis, most reliably reflected taxonomic relationships of the species from the genus Spermophilus, inferred from morphological and genetic biochemical data. The morphologically pure S. major (subgenus Colobotis) animals, used in the analysis, proved to carry the haplotype of another species, S. pygmaeus (subgenus Citellus). This poses a question on the existence of the specific haplotype of S. major, the reason of its replacement by haplotype of other species, and possible consequences of this phenomenon for survival of the species.
- Published
- 2006
- Full Text
- View/download PDF
39. Control, data acquisition and remote participation for steady-state operation in LHD
- Author
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J. Miyazawa, Mamoru Shoji, Lhd Team, Hirotaka Chikaraishi, S. Imazu, Tetsuo Seki, Masanobu Yoshida, Takashi Mutoh, Yuichiro Kogi, M. Nonomura, Yoshio Nagayama, S. Komada, Mamoru Kojima, Hideya Nakanishi, Kenji Saito, Masahiko Emoto, Ryuhei Kumazawa, M. Ohsuna, Ryuichi Sakamoto, Shigeru Sudo, K. Tsuda, Shin Kubo, Atsushi Mase, C. Iwata, and Y. Nakamura
- Subjects
Steady state (electronics) ,Computer science ,Mechanical Engineering ,Real-time computing ,Local area network ,Control room ,Remote operation ,Large Helical Device ,Data acquisition ,Nuclear Energy and Engineering ,Teleoperation ,General Materials Science ,CompactPCI ,Civil and Structural Engineering - Abstract
Control, data acquisition, plasma monitoring and remote participation for steady state operation in the large helical device (LHD) are reviewed. By controlling the impedance matching of ICH, the plasma position and the electron density, high temperature plasma is confined for 1905s. The plasma parameters are monitored in real time. Data are continuously sampled by the YOKOGAWA WE7000 system and by the NATIONAL INSTRUMENTS CompactPCI system. Those data are managed by the object-oriented database system based on ObjectStore in distributed servers with mass storage. By using the multi protocol label switching-virtual private network (MPLS-VPN) technology, the local area network of LHD is expanded to the Japanese fusion community. This provides the remote participants with the same environment of the LHD control room.
- Published
- 2006
- Full Text
- View/download PDF
40. Evaluation System for Earthquake Resistant Performance of Reinforced Concrete Buildings
- Author
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K. Sugimoto, K. Ichikawa, K. Tsuda, and T. Kawabata
- Subjects
Engineering ,Earthquake engineering ,Evaluation system ,business.industry ,Forensic engineering ,General Materials Science ,Earthquake resistant ,Geotechnical engineering ,Reinforced concrete ,business - Published
- 2006
- Full Text
- View/download PDF
41. Effects of fertilizer application on yield and vitamin C content of tomato inoculated with the attenuated isolate CM95 of Cucumber mosaic virus
- Author
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Y. Kosaka, M. Kataoka, T. Kobori, H. Shiomi, K. Musumi, and K. Tsuda
- Subjects
Cucumber mosaic virus ,Cucumber mosaic virus CMV ,Agronomy ,Vitamin C ,Inoculation ,Yield (wine) ,Biological pest control ,engineering ,food and beverages ,Fertilizer ,engineering.material ,Biology - Abstract
After tomato plants were inoculated with an attenuated isolate CM95 of Cucumber mosaic virus (CMV), a promising biocontrol agent for CMV, either the number or weight of marketable fruits was reduced when a basal level of fertilizer was added to rock wool or soil culture in aphid-proof plastic houses. However, increasing the amount of fertilizer when applied as a solution or side dressing hardly reduced yield while significantly increasing vitamin C in tomato fruits.
- Published
- 2005
- Full Text
- View/download PDF
42. Development of High Beaing Capacity Embedded Piling Method (H.B.M. Method) Utilising Prefabricated Concrete Piles
- Author
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K. Tsuda
- Subjects
General Materials Science - Published
- 2003
- Full Text
- View/download PDF
43. ANEMONA — a neutron transport code for general geometry reactor assemblies based on the method of characteristics and R-function solid modeler
- Author
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T. Jevremovic, K. Tsuda, and Jasmina Vujic
- Subjects
Neutron transport ,Nuclear Energy and Engineering ,Method of characteristics ,Total derivative ,Boundary (topology) ,Ray tracing (graphics) ,Geometry ,Convection–diffusion equation ,Reduction (mathematics) ,Boltzmann equation ,Mathematics - Abstract
The method of characteristics (MOC) solves the transport equation along straight lines, called characteristics, of the system. Along these lines the differential operator of the Boltzmann equation reduces to a total derivative. The MOC methodology does not impose any limitation on geometry and allows for an accurate treatment of highly heterogeneous systems. However, the actual treatment of arbitrary domains in terms of their flexible description and efficient ray tracing does impose difficulties which limited broader application of MOC in reactor analysis. Most of the existing MOC codes describe the geometry by lines and arcs with extensive input data, have difficulty in sub-meshing, require a pre-defined condition of closed rays at starting points limiting the boundary shape, and need a large number of polar angles which prolong the execution time. A new MOC code, ANEMONA, has been developed to remove all these geometrical limitations. This unified and easy-to-use method is based on an R -function solid modeler approach that can account for all heterogeneities with full flexibility in domain description, ray map generation, ray tracing and boundary types. The ANEMONA's methodology has many advantages: an easy description of arbitrary domains and meshing; allowed mismatch of the reflected rays; calculation of the reflected angular flux as the boundary mesh average; use of only two adequately chosen polar angles; and the reduction in computational time by energy-dependent azimuthal ray map. ANEMONA has been tested on a number of benchmark problems with excellent results.
- Published
- 2001
- Full Text
- View/download PDF
44. An attempt for coloring multichannel MR imaging data
- Author
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K. Tsuda, Y. Kita, S. Muraki, and T. Nakai
- Subjects
Radial basis function network ,medicine.diagnostic_test ,Artificial neural network ,Computer science ,business.industry ,Magnetic resonance imaging ,Pattern recognition ,computer.software_genre ,Computer Graphics and Computer-Aided Design ,Sample (graphics) ,Independent component analysis ,Data set ,Voxel ,Signal Processing ,medicine ,Computer vision ,Computer Vision and Pattern Recognition ,Artificial intelligence ,business ,computer ,Software ,Volume (compression) - Abstract
This is an elementary research into assigning color values to voxels of multi-channel magnetic resonance imaging (MRI) volume data. The MRI volume data sets obtained under different scanning conditions are transformed into components by independent component analysis (ICA), which enhances the physical characteristics of the tissue. The transfer functions for generating color values from the independent components are obtained by using a radial basis function network, a kind of neural net, by training the network with sample data chosen from the Visible Human female data set (VHF). The resultant color volume data sets correspond well with the full-color cross-sections of the Visible Human data sets.
- Published
- 2001
- Full Text
- View/download PDF
45. Fluorescence from azobenzene functionalized poly(propylene imine) dendrimers in self-assembled supramolecular structures
- Author
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J.W. Weener, K. Tsuda, G.C. Dol, F. C. De Schryver, E. W. Meijer, Loredana Latterini, T. Gensch, Johan Hofkens, Macromolecular and Organic Chemistry, and Macro-Organic Chemistry
- Subjects
Photoisomerization ,Supramolecular chemistry ,POLYMERIC LIQUID-CRYSTALS ,CIS-TRANS ISOMERIZATION ,REVERSIBLE OPTICAL STORAGE ,Photochemistry ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,MOLECULES ,Colloid and Surface Chemistry ,AMORPHOUS POLYMERS ,BILAYER-MEMBRANES ,AZO POLYMERS ,PHOTOISOMERIZATION ,ORIENTATION ,MICELLES ,Dendrimer ,Chemistry ,Bilayer ,Vesicle ,General Chemistry ,Chromophore ,Cis trans isomerization ,Azobenzene - Abstract
Higher generations of poly(propylene imine) dendrimers functionalized with aliphatic chains form large micrometer-sized spherical objects in aqueous solution below pH 8. These spheres are giant vesicles with a multilaminar onion-like structure. The size distribution and the structure of the vesicles depend on the pH of the solution and the endgroups at the periphery of the dendrimer. The vesicles containing azobenzene units (2 and 3) fluoresce with a maximum at ¿max = 600 nm. This emission can be attributed to the dense and ordered arrangement of the azobenzene chromophores in the bilayer structure. Laser irradiation of a small area of giant vesicles of 2 or 3 with 1064 and/or 420 nm light leads to changes in the morphology of the vesicles. Infrared light induces a rearrangement, whereas the azobenzene units isomerize under the influence of 420 nm light. Both irradiations lead to a change in refractive index in the illuminated area. Irradiation using 420 nm light is accompanied by an increase in the emission intensity. In aqueous solutions at pH 1, the increase in fluorescence intensity is concurrent with a blue shift of the emission maximum to 540 nm. This blue shift is not observed when the experiment is performed in Milli Q water (pH 5.5). The enhanced fluorescence can be attributed to reorganization of the chromophores within the giant vesicle. The increase in emission proves that the giant vesicle is a kinetically formed system that reaches a thermodynamically more relaxed state after light-induced isomerization.
- Published
- 2000
- Full Text
- View/download PDF
46. The role of sodium-potassium adenosine triphosphatase in the regulation of membrane fluidity of erythrocytes in spontaneously hypertensive rats An electron paramagnetic resonance investigation
- Author
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K Tsuda
- Subjects
Internal Medicine - Published
- 1997
- Full Text
- View/download PDF
47. 44th ORCA Congress, July 2-5, 1997, Dundee, UK (Part 2 of 4)
- Author
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M. Kim, Antheunis Versluis, J. Katz, Masatomo Hirasawa, William H. Douglas, M.A.B. Rebello, T.J.M. van Steenbergen, Jaime Aparecido Cury, A.J.P. van Strijp, Peter Lingström, Kim R. Ekstrand, Gordon B. Gray, Solveig Fure, M. Ozeki, Lars G. Petersson, K. Sjögren, Robert C. Paterson, Shigeo Otake, A.A. Del Bel Cury, T. Yamamoto, K. Tsuda, Suzanne M. Michalek, T. J. Butler, S.M. Al-Mohammadi, Andrew Rugg-Gunn, A.-B. Lundberg, Dowen Birkhed, J.M. ten Cate, H. Hatta, Noel K. Childers, L. Bjørndal, Daranee Tantbirojn, and Svante Twetman
- Subjects
General Dentistry - Published
- 1997
- Full Text
- View/download PDF
48. 44th ORCA Congress, July 2-5, 1997, Dundee, UK
- Author
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Suzanne M. Michalek, Peter Lingström, Lars G. Petersson, M. Ozeki, J.M. ten Cate, T. Yamamoto, A.-B. Lundberg, Jaime Aparecido Cury, Svante Twetman, Shigeo Otake, Masatomo Hirasawa, L. Bjørndal, A.A. Del Bel Cury, H. Hatta, J. Katz, William H. Douglas, Daranee Tantbirojn, T. J. Butler, Robert C. Paterson, T.J.M. van Steenbergen, S.M. Al-Mohammadi, Solveig Fure, K. Sjögren, Noel K. Childers, K. Tsuda, Gordon B. Gray, Andrew Rugg-Gunn, M.A.B. Rebello, A.J.P. van Strijp, Kim R. Ekstrand, M. Kim, Dowen Birkhed, and Antheunis Versluis
- Subjects
General Dentistry - Published
- 1997
- Full Text
- View/download PDF
49. 44th ORCA Congress, July 2-5, 1997, Dundee, UK (Part 3 of 4)
- Author
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Masatomo Hirasawa, Suzanne M. Michalek, A.-B. Lundberg, William H. Douglas, T.J.M. van Steenbergen, Andrew Rugg-Gunn, Kim R. Ekstrand, J.M. ten Cate, M. Ozeki, Shigeo Otake, Noel K. Childers, Dowen Birkhed, Jaime Aparecido Cury, M. Kim, Gordon B. Gray, K. Sjögren, Robert C. Paterson, T. J. Butler, A.A. Del Bel Cury, S.M. Al-Mohammadi, Antheunis Versluis, M.A.B. Rebello, H. Hatta, A.J.P. van Strijp, J. Katz, K. Tsuda, L. Bjørndal, Daranee Tantbirojn, Svante Twetman, Peter Lingström, Lars G. Petersson, T. Yamamoto, and Solveig Fure
- Subjects
Veterinary medicine ,business.industry ,Medicine ,Library science ,business ,General Dentistry - Published
- 1997
- Full Text
- View/download PDF
50. 44th ORCA Congress, July 2-5, 1997, Dundee, UK (Part 4 of 4)
- Author
-
Noel K. Childers, K. Tsuda, J. Katz, A.J.P. van Strijp, A.-B. Lundberg, Peter Lingström, Jaime Aparecido Cury, Robert C. Paterson, M. Ozeki, Lars G. Petersson, Shigeo Otake, S.M. Al-Mohammadi, T. Yamamoto, H. Hatta, M.A.B. Rebello, Daranee Tantbirojn, Solveig Fure, Suzanne M. Michalek, Antheunis Versluis, J.M. ten Cate, William H. Douglas, T. J. Butler, Dowen Birkhed, K. Sjögren, Masatomo Hirasawa, Andrew Rugg-Gunn, L. Bjørndal, T.J.M. van Steenbergen, Kim R. Ekstrand, M. Kim, A.A. Del Bel Cury, Svante Twetman, and Gordon B. Gray
- Subjects
General Dentistry - Published
- 1997
- Full Text
- View/download PDF
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