1. Early-life exposure to lipopolysaccharide reduces the severity of experimental autoimmune encephalomyelitis in adulthood and correlated with increased urine corticosterone and apoptotic CD4+ T cells
- Author
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Z.-W. Wang, F.-H. Lin, Li Xiaokun, Rong-yuan Zheng, K. Thomas O'Byrne, P. Wang, Xiao Feng Li, and Sheng T. Hou
- Subjects
CD4-Positive T-Lymphocytes ,Lipopolysaccharides ,Time Factors ,Lipopolysaccharide ,CD3+ T lymphocyte ,correlation analysis ,urinalysis ,Encephalomyelitis ,Freund's Adjuvant ,Apoptosis ,animal cell ,Severity of Illness Index ,immune response ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,allergic encephalomyelitis ,regulatory T lymphocyte ,Corticosterone ,Medicine ,rat ,Annexin A5 ,biology ,General Neuroscience ,lipopolysaccharide ,Experimental autoimmune encephalomyelitis ,Flow Cytometry ,Spinal Cord ,immunohistochemistry ,disease severity ,neuroprotection ,Glucocorticoid ,medicine.drug ,medicine.medical_specialty ,drug exposure ,Encephalomyelitis, Autoimmune, Experimental ,immunoregulation ,CD3 ,animal experiment ,lymphocyte proliferation ,immunization ,Statistics, Nonparametric ,animal tissue ,Immune system ,Antigen ,Antigens, CD ,Internal medicine ,Animals ,Cell Proliferation ,CD4+ T lymphocyte ,Analysis of Variance ,business.industry ,animal model ,disease predisposition ,Histocompatibility Antigens Class II ,medicine.disease ,Rats ,Disease Models, Animal ,Endocrinology ,chemistry ,Animals, Newborn ,antigen presenting cell ,Immunology ,biology.protein ,business ,upregulation - Abstract
Early-life exposure to bacterial endotoxins, such as lipopolysaccharides (LPS), can provide neuroprotection against experimental autoimmune encephalomyelitis (EAE) during adulthood, possibly through altering the responsiveness of the immune system. Here, we show that exposure of LPS to neonatal rats resulted in a sustained elevation of corticosterone level in urine when compared with saline-treated rats, and that the high level of urine corticosterone was maintained during the progression of EAE (P
- Published
- 2011