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International wild Atlantic salmon management priorities have moved from exploitation to conservation since the 1990s, recognizing the need to protect diversity and abundance at individual river levels amid widespread declines. Here we review international salmon-stock assessments and describe a simple, transferable catch-advice framework, established for management of fisheries that conforms to international obligations. The risk assessment approach, applied at the river scale, jointly incorporates uncertainty in estimated and forecasted returning salmon numbers with the level of uncertainty around spawning requirements (Conservation Limits). Outputs include quantification of risk of stocks not attaining conservation limits (CL) and surpluses above CL on stocks able to support sustainable exploitation via total allowable catches (TAC), with monitoring by rod catch or fish counter. Since management implementation and cessation of at-sea mixed-stock fisheries, there has been a deterioration in the performance of many individual stocks, without any sustained increase in fisheries open to harvest. Given declines in mid-latitude Atlantic salmon populations over 30 years, the novel framework presented provides an approach to protect stocks failing to meet spawning thresholds while supporting sustainable exploitation of those achieving them. On-going management policy of adopting scientific advice and allowing exploitation only on stocks exceeding CLs is central to the objective of protecting salmon stocks.

This article examines the effectiveness of private dispute resolution arrangements (PDRAs) established voluntarily by employers and unions in private- and public-sector firms and agencies in Ireland. PDRAs comprise three-person panels or sole adjudicators and combine binding or non-binding adjudication with internal mediation. PDRAs seek to rewrite the established rules and conventions governing dispute resolution within workplaces and to change the ways in which internal dispute resolution is aligned with external dispute resolution by state agencies. The majority of the eleven PDRAs examined are shown to be effective. One is described as ‘semi-dormant’ and two are shown to be less effective. Variations in the effectiveness of PDRAs are attributed to features of the internal and external contexts of the firms and agencies in which they have been established: the persistence of significant commercial and industrial relations challenges; the absence of disjunctures in organisations or industrial relations; the presence of champions; and the effects of industrial relations legacies. The paper contributes to the literature by systematically accounting for variations in the effectiveness of adjudication and arbitrations arrangements and concludes by considering whether the incidence of PDRAs is likely to continue rising.

This article examines the genesis of private dispute resolution arrangements introduced by employers and unions in Ireland. These forms of collective alternative dispute resolution (ADR) comprise three‐person panels or sole adjudicators, who mediate and issue findings on collective disputes. Findings may be non‐binding or binding. Using data and interviews covering 11 private dispute resolution arrangements in 10 organisations, the paper identifies the circumstances in which they have emerged and a series of influences that lead employers and unions make path‐breaking changes in dispute resolution procedures.

This paper reviews human resource management (HRM) reforms in the Irish public service over the past twenty-five years. The narrative is based around five HRM themes which have been the main focus of public service reform efforts: performance management, public service careers, leadership, strategic HRM and employment relations. The paper examines all available independent empirical research as well as internal and external reviews commissioned by the public service. The paper contributes to the empirical literature on HRM in the public service and in Ireland, and locates the pattern of HRM reform in the public service in Ireland in comparative context. The paper concludes by noting that while progress has been made, further energy is required in respect of HRM reform.

The paleogeographic position of the central Dodecanese Islands at the transition between the Aegean and Anatolian plates plays a considerable role in understanding the link between both geologically unique domains. In this study, we investigate the tectonic history of the central Dodecanese Islands and the general correlation with the Aegean and western Anatolian and focus on the poorly studied islands of Kalymnos and Telendos. Three different major tectonic units were mapped on both islands from bottom to top: (1) The Kefala Unit consists of late Paleozoic, fossil-rich limestones, which have been deformed into a SE-vergent fold-and-thrust belt sealed by an up to 200-m-thick wildflysch-type olistostrome with marble and ultramafic blocks on a scale of tens of meters. (2) The Marina Basement Unit consists of a Variscan amphibolite facies basement with garnet mica schists, quartzites, and amphibolites. (3) Verrucano-type formation violet shales and Mesozoic unmetamorphosed limestones form the Marina Cover Unit. Correlation of these units with other units in the Aegean suggests that Kalymnos is paleogeo-graphically located at the southern margin of the Pelagonian domain, and therefore it was in a structurally upper tectonic position during the Paleogene Alpine orogeny. New white mica 40Ar/39Ar ages confirm the Carboniferous deformation of the Marina Basement Unit followed by a weak Triassic thermal event. Single-grain white mica 40Ar/39Ar ages from pressure solution cleavage of the newly defined Telendos Thrust suggest that the Marina Basement Unit was thrusted toward the north on top of the Kefala Unit in the Paleocene. Located at a tectonically upper position, the units exposed in the central Dodecanese escaped subduction and the syn-orogenic, high-pressure metamorphism. However, these units were affected by post-orogenic extension, and the contact between the Marina Basement Unit and the non-metamorphic Marina Cover Unit has been reactivated by the cataclastic top-to-SSW, low-angle Kalymnos Detachment. Zircon (U-Th)/He ages from the Kefala and Marina Basement Units are ca. 30 Ma, which indicates that exhumation and cooling below the Kalymnos Detachment started in the Oligocene. Conjugate brittle high-angle normal fault systems, which resulted in the formation of four major WNW-ESE-trend-ing graben systems on Kalymnos, localized mainly in the Marina Cover Unit and probably rooted in the mechanically linked Kalymnos Detachment. Since Oligo-Miocene deformation in the northern Dodecanese records top-to-NNE extension and the Kalym-nos Detachment accommodated top-to-SSW extension, we suggest that back-arc extension in the whole Aegean realm and transition to the Anatolian plate is bivergent. © 2022 Geological Society of America. All Rights Reserved.

Patterns of feeding and growth of Atlantic salmon Salmo salar L. in the marine environment are critical to understanding how observed declines in recruitment may reflect warming or other oceanic drivers. The isotopic composition of scales can provide insight into differences in marine feeding location and possibly temperature regime. The authors used archived scale samples to measure δ

Human gut microbial dynamics are highly individualized, making it challenging to link microbiota to health and to design universal microbiome therapies. This individuality is typically attributed to variation in host genetics, diets, environments and medications but it could also emerge from fundamental ecological forces that shape microbiota more generally. Here, we leverage extensive gut microbial time series from wild baboons-hosts who experience little interindividual dietary and environmental heterogeneity-to test whether gut microbial dynamics are synchronized across hosts or largely idiosyncratic. Despite their shared lifestyles, baboon microbiota were only weakly synchronized. The strongest synchrony occurred among baboons living in the same social group, probably because group members range over the same habitat and simultaneously encounter the same sources of food and water. However, this synchrony was modest compared to each host's personalized dynamics. In support, host-specific factors, especially host identity, explained, on average, more than three times the deviance in longitudinal dynamics compared to factors shared with social group members and ten times the deviance of factors shared across the host population. These results contribute to mounting evidence that highly idiosyncratic gut microbiomes are not an artefact of modern human environments and that synchronizing forces in the gut microbiome (for example, shared environments, diets and microbial dispersal) are not strong enough to overwhelm key drivers of microbiome personalization, such as host genetics, priority effects, horizontal gene transfer and functional redundancy.

Este artículo contiene 15 páginas, 3 tablas, 2 figuras., A comprehensive set of measurements and calculated metrics describing physical, chemical, and biological conditions in the river corridor is presented. These data were collected in a catchment-wide, synoptic campaign in the H. J. Andrews Experimental Forest (Cascade Mountains, Oregon, USA) in summer 2016 during low-discharge conditions. Extensive characterization of 62 sites including surface water, hyporheic water, and streambed sediment was conducted spanning 1st- through 5th-order reaches in the river network. The objective of the sample design and data acquisition was to generate a novel data set to support scaling of river corridor processes across varying flows and morphologic forms present in a river network., This research has been supported by the Leverhulme Trust (“Where rivers, groundwater and disciplines meet: a hyporheic research network”), the UK Natural Environment Research Council (grant no. NE/L003872/1), the U.S. Department of Energy (Pacific Northwest National Laboratory, grant no. DESC0019377), the National Science Foundation (grant nos. DEB- 1440409, EAR-1652293, EAR-1417603, and EAR-1446328), the University of Birmingham (grant no. Institute of Advanced Studies), and the European Commission (HiFreq, grant no. 734317).

The Rudall Province in Western Australia is a key crustal component in the amalgamation of the Rodinia supercontinent. New field observations, U–Pb zircon geochronology and geochemistry identify three previously unrecognised Mesoproterozoic magmatic events in the eastern Rudall Province. The Kayilirra Suite formed at ca. 1500 Ma and is a magnesian, calc-alkalic to alkali-calcic and weakly peraluminous suite with a limited SiO2 range of 69–70 wt%. The suite is interpreted to have formed in either a post-tectonic or rift-related setting. The Kalyukuyarra Suite formed at ca. 1185–1165 Ma and was synchronous with a peak in magmatic activity in the along-strike Musgrave Province. The suite is magnesian to ferroan, alkali-calcic and calc-alkalic, high K and peraluminous. Abundant inherited zircon grains indicate a dominantly crustal origin for the suite with only minor interpreted mantle input. Newly identified mafic and felsic magmatism was associated with the ca. 1380–1275 Ma Parnngurr Orogeny and further establishes correlations with the Mount West Orogeny in the Musgrave Province and “Stage 1” of the Albany-Fraser Orogeny. The new data support the progressive, final amalgamation of the Australian-Antarctic crustal fragments during the period ca. 1380–1250 Ma through consumption of oceanic crust below the over-riding West Australian Craton. Refereed/Peer-reviewed

This article examines the features and effectiveness of 11 ‘private dispute resolution arrangements’ (PDRAs) established by employers and unions in Ireland since the early 2000s to resolve collective disputes within organizations. These PDRAs are groundbreaking in redrawing the rules aligning internal dispute resolution with services provided by external state agencies. The article extends the boundaries of our knowledge of alternative dispute resolution (ADR) by highlighting the features of PDRAs and by identifying the conditions contributing to their evenhandedness, fairness and independence.

Drawing on the international literature on pattern bargaining in Europe and other countries, the article examines the recent advent of pattern bargaining in Irish industrial relations. Qualitative and quantitative data are deployed to explore the genesis, features, institutional and economic context and future of pattern bargaining in Ireland.

This paper examines the development of procedures for conflict resolution in workplaces in Ireland and the more recent emergence of alternative dispute resolution (ADR) practices. Based on a synthesis of data from a series of studies and on a review of reports of conflict resolution innovations, the paper shows how conventional procedures for resolving collective disputes and individual employment grievances had become almost standard by the 1980s, while a series of ADR practices became features of conflict resolution from the 1990s. The changing character of conflict resolution procedures and practices is attributed to a series of influences that include the professionalisation of personnel and human resource management, the changing pattern and context of workplace conflict, the growing importance of multinational firms, and the emergence of professional training and expertise in the provision of ADR support services. The paper projects a continuing rise in the incidence and use of ADR practices but questions the extent to which organisations in Ireland are likely to adopt conflict management systems based on integrated sets of conflict resolution practices.

This article examines whether organizations in Ireland are following their counterparts in the United States and adopting advanced conflict management innovations inspired by alternative dispute resolution. The authors find that the general pattern in Ireland is for organizations to change conflict management practices in a reactive, piecemeal manner that seldom involves any proactive or strategic action. They also identify a small group of organizations that adopt an incremental and evolutionary approach to workplace conflict management innovation that involves changing tried-and-tested conflict management practices pragmatically over time. The article suggests that apart from the United States, all other Anglo-American countries for the most part follow the pattern of workplace conflict change occurring in Ireland.

Este artículo contiene 28 páginas, 6 figuras, 4 tablas., Although most field and modeling studies of river corridor exchange have been conducted at scales ranging from tens to hundreds of meters, results of these studies are used to predict their ecological and hydrological influences at the scale of river networks. Further complicating prediction, exchanges are expected to vary with hydrologic forcing and the local geomorphic setting. While we desire predictive power, we lack a complete spatiotemporal relationship relating discharge to the variation in geologic setting and hydrologic forcing that is expected across a river basin. Indeed, the conceptual model of Wondzell (2011) predicts systematic variation in river corridor exchange as a function of (1) variation in baseflow over time at a fixed location, (2) variation in discharge with location in the river network, and (3) local geomorphic setting. To test this conceptual model we conducted more than 60 solute tracer studies including a synoptic campaign in the 5th-order river network of the H. J. Andrews Experimental Forest (Oregon, USA) and replicate-intime experiments in four watersheds. We interpret the data using a series of metrics describing river corridor exchange and solute transport, testing for consistent direction and magnitude of relationships relating these metrics to discharge and local geomorphic setting. We confirmed systematic decrease in river corridor exchange space through the river networks, from headwaters to the larger main stem. However, we did not find systematic variation with changes in discharge through time or with local geomorphic setting. While interpretation of our results is complicated by problems with the analytical methods, the results are sufficiently robust for us to conclude that space-for-time and time-for-space substitutions are not appropriate in our study system. Finally, we suggest two strategies that will improve the interpretability of tracer test results and help the hyporheic community develop robust datasets that will enable comparisons across multiple sites and/or discharge conditions., This research has been supported by the Leverhulme Trust (Where rivers, groundwater and disciplines meet: a hyporheic research network), the UK Natural Environment Research Council (grant no. NE/L003872/1), the European Commission, H2020 Marie Skłodowska-Curie Actions (HiFreq (grant no. 734317)), the U.S. Department of Energy (Pacific Northwest National Lab and DE-SC0019377), the National Science Foundation (grant nos. DEB-1440409, EAR-1652293, EAR-1417603, and EAR-1446328), and the University of Birmingham (Institute of Advanced Studies).

Background: Development of targeted therapies for high-grade serous ovarian cancer (HGSC) remains challenging, as contributing molecular pathways are poorly defined or expressed heterogeneously. CUB-domain containing protein 1 (CDCP1) is a cell-surface protein elevated in lung, colorectal, pancreas, renal and clear cell ovarian cancer. Methods: CUB-domain containing protein 1 was examined by immunohistochemistry in HGSC and fallopian tube. The impact of targeting CDCP1 on cell growth and migration in vitro, and intraperitoneal xenograft growth in mice was examined. Three patient-derived xenograft (PDX) mouse models were developed and characterised for CDCP1 expression. The effect of a monoclonal anti-CDCP1 antibody on PDX growth was examined. Src activation was assessed by western blot analysis. Results: Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo. Expression of CDCP1 in patient samples was maintained in PDX models. Antibody blockade of CDCP1 significantly reduced growth of an HGSC PDX. The CDCP1-mediated activation of Src was observed in cultured cells and mouse xenografts. Conclusions: CUB-domain containing protein 1 is over-expressed by the majority of HGSCs. In vitro and mouse model data indicate that CDCP1 has a role in HGSC and that it can be targeted to inhibit progression of this cancer.

Light, scanning, and transmission electron microscopy are used to examine the morphology and ultrastructure of the peculiar digestive tract of the turtle ant, Zacryptocerus rohweri. The proventriculus is heavily sclerotized and covered with clusters of small spines. Narrow spine-lined channels converging at the opening to the midgut act as a fine filter of food; particles12.5 μm are unable to pass through the proventriculus. In the midgut, ultrastructural study reveals bacteria among the microvilli of midgut epithelial cells. The hindgut of Z. rohweri consists of an enlarged, dark-colored pouch filled with masses of bacteria of three major morphotypes. A thick layer of circular muscle and deep infoldings of the epithelium greatly increase surface area for absorption. Newly emerged individuals appear to acquire these microorganisms by soliciting material from the abdomen tip of other older workers in the colony. Whether or not the hindgut bacteria are true symbionts is unknown; their acquisition and presence suggest that they may supplement the ants' limited, liquid diet by supplying essential amino acids and other nutrients. J. Morphol. 234:253-262, 1997. © 1997 Wiley-Liss, Inc.

[Departement_IRSTEA]Territoires [TR1_IRSTEA]SEDYVIN [ADD1_IRSTEA]Dynamique et fonctionnement des écosystèmes; International audience; The concept of ecosystem disservices (EDS) has received much less attention than the concept of ecosystem services (ES). Using an expert-based matrix approach, we assessed the capacity of ecosystem types of the Scarpe-Escaut Regional Natural Park (France) to both provide ES and generate EDS. The matrix is a look-up table that provide for each ecosystem types a score expressing its ES capacity. Our results point to a lower capacity of the considered ecosystems to provide EDS than ES. On average the EDS scores were 60% lower than the ES scores. Of EDS, those linked to human health are the most critical, with higher capacity scores and higher expert' confidence scores than other EDS than those linked with economic or ecological impacts. We analysed correlations between ES and EDS, the presence of strong and significant positive correlations suggests that the same ecosystem characteristics, ecological functions or species groups may generate both ES and EDS. We emphasise that it is important to evaluate both EDS and ES to implement management of the ecosystems, while respecting the functioning of the ecosystems, to develop positive effects while limiting negative ones.

This article examines the practice of private facilitation in Irish industrial relations, drawing on interviews with key practitioners and on case studies. It explores antecedents of private facilitation, examines the multiple processes involved, identifies influences on the growth of private facilitation and locates the Irish case in comparative context.

The cause of schizophrenia (SZ) is unknown and no single region of the brain can be pinpointed as an area of primary pathology. Rather, SZ results from dysfunction of multiple neurotransmitter systems and miswiring between brain regions. It is necessary to elucidate how communication between regions is disrupted to advance our understanding of SZ pathology. The nucleus accumbens (NAcc) is a prime region of interest, where inputs from numerous brain areas altered in SZ are integrated. Aberrant signaling in the NAcc is hypothesized to cause symptoms of SZ, but it is unknown if these abnormalities are actually present. Electron microscopy was used to study the morphology of synaptic connections in SZ. The NAcc core and shell of 6 SZ subjects and 8 matched controls were compared in this pilot study. SZ subjects had a 19% increase in the density of asymmetric axospinous synapses (characteristic of excitatory inputs) in the core, but not the shell. Both groups had similar densities of symmetric synapses (characteristic of inhibitory inputs). The postsynaptic densities of asymmetric synapses had 22% smaller areas in the core, but not the shell. These results indicate that the core receives increased excitatory input in SZ, potentially leading to dysfunctional dopamine neurotransmission and cortico-striatal-thalamic stimulus processing. The reduced postsynaptic density size of asymmetric synapses suggests impaired signaling at these synapses. These findings enhance our understanding of the role the NAcc might play in SZ and the interaction of glutamatergic and dopaminergic abnormalities in SZ.

Schizophrenia is a severe mental illness affecting approximately 1% of the population worldwide. Despite its prevalence, the cause remains unknown, and treatment is not effective in all patients. Dopamine is thought to play a role in schizophrenia pathology, yet the substantia nigra (SN), the origin of dopaminergic pathways, has not been studied extensively in schizophrenia. In this study, electron microscopy was used to examine neurons, oligodendrocytes, and myelinated axons in the SN of normal controls (NCs, n=9) and schizophrenia subjects with varying response to antipsychotic drugs [SZ, n=14; treatment resistant (TR)=6, treatment responsive (RESP)=6, unknown=2]. Postmortem tissue was analyzed for qualitative and quantitative markers of ultrastuctural integrity. A significantly higher percentage of axons in the schizophrenia group had inclusions in the myelin sheath compared to NCs (SZ: 3.9±1.7, NC: 2.6±2.0). When considering treatment response, a significantly higher percentage of axons lacked cytoplasm (TR: 9.7±5.5, NC: 3.5±2.3), contained cellular debris (TR: 7.5±3.2, NC: 2.3±1.3) or had protrusions in the myelin sheath (TR: 0.4±0.5, NC: 0.2±0.3). The G-ratio, a measure of myelin thickness, was significantly different between treatment response groups and was greater in TR (0.72±0.02) as compared to NCs (0.68±0.03), indicating decreased myelination in TR. These findings, which suggest myelin pathology in the SN in schizophrenia, are consistent with findings elsewhere in the brain. In addition, our results suggest cytoskeletal abnormalities, which may or may not be associated with myelin pathology.

The issue of concession bargaining between employers and unions during the Great Recession has received little attention in the research literature. This article presents a systematic analysis of the conduct of concession bargaining during the recession in Ireland in the context of three forms of concession bargaining identified in the international literature: integrative concession bargaining, distributive concession bargaining and ultra concession bargaining – each with different but overlapping sets of institutional foundations and implications for employers and trade unions. Drawing on focus groups of managers and union officials and a representative survey of employers, the article shows that distributive concession bargaining has been the predominant form in the Irish recession. This form of concession bargaining is likely to have few lasting direct effects on employer or union roles in collective bargaining but nevertheless appears to have significant indirect implications for the silent marginalization of unions in workplaces.

The process of glutamate release, activity, and reuptake involves the astrocyte, the presynaptic and postsynaptic neuron. Glutamate is released into the synapse and may occupy and activate receptors on both neurons and astrocytes. Glutamate is rapidly removed from the synapse by a family of plasma membrane excitatory amino acid transporters (EAATs), also localized to neurons and astrocytes. The purpose of the present study was to examine EAAT labeling in postmortem human cortex at the light and electron microscopic levels. Postmortem prefrontal cortex was processed for EAAT1 and EAAT2 immunohistochemistry. At the light microscopic level, EAAT1 and EAAT2 labeling was found in both grey and white matter. Most cellular labeling was in small cells which were morphologically similar to glia. In addition, EAAT1 labeled neurons were scattered throughout, some of which were pyramidal in shape. At the electron microscopic level, EAAT1 and EAAT2 labeling was found in astrocytic soma and processes surrounding capillaries. EAAT labeling was also found in small astocytic processes adjacent to axon terminals forming asymmetric (glutamatergic) synapses. While EAAT2 labeling was most prevalent in astrocytic processes, EAAT1 labeling was also present in neuronal processes including the soma, axons, and dendritic spines. Expression of EAAT1 protein on neurons may be due to the hypoxia associated with the postmortem interval, and requires further confirmation. The localization of EAATs on the astrocytic plasma membrane and adjacent to excitatory synapses is consistent with the function of facilitating glutamate reuptake and limiting glutamate spillover. Establishment that EAAT1 and EAAT2 can be measured at the EM level in human postmortem tissues will permit testing of hypotheses related to these molecules in diseases lacking analogous animal models.

In international commentary and debate on the effects of the Great Recession and austerity, Ireland has been hailed as the poster child for economic recovery and regeneration out of deep economic and fiscal contraction. While the genesis of Ireland's financial, economic and fiscal crisis has been covered in the literature, no systematic analysis has yet been devoted to the period of austerity, to the impact of austerity on institutions and people, or to the roots of economic recovery. In this book a group of Ireland's leading social scientists present a multi-disciplinary analysis of recession and austerity and their effects on economic, business, political and social life. Individual chapters discuss the fiscal and economic policies implemented, the role of international, and, in particular, of EU institutions, and the effects on businesses, consumption, work, the labour market, migration, political and financial institutions, social inequality and cohesion, housing and cultural expression. The book shows that Ireland cannot be viewed uncritically as a poster child for austerity. While fiscal contraction provided a basis for stabilizing the perilous finances of the State, economic recovery was due in the main to the long-established structure of Irish economic and business activity, to the importance of foreign direct investment and the dynamic export sector, and to recovery in the international economy. The restructuring and recovery of the financial system was aided by favourable international developments, including historically low interest rates and quantitative easing. Migration flows, nominal wage stability, the protection of social transfer payments and the involvement of trade unions in severe public sector retrenchment - long-established features of Irish political economy - were of critical importance in the maintenance of social cohesion. Contributors to this volume - Frank Barry, Trinity College Dublin Adele Bergin, ESRI Donald Taylor Black, documentary filmmaker, writer, and educator Richard Boyle, Institute of Public Administration, Ireland Sara Cantillon, Glasgow Caledonian University Blanaid Clarke, Trinity College Dublin Marius Claudy, University College Dublin Gregory Connor, Maynooth University Margaret Crean, University College Dublin David Farrell, University College Dublin Thomas Flavin, Maynooth University Irial Glynn, Leiden University Rory Hearne, TASC Andrew Keating, University College Dublin Stephen Kinsella, University of Limerick Rob Kitchin, Maynooth University Brigid Laffan, European University Institute, Florence Kathleen Lynch, University College Dublin Cian O'Callaghan, Trinity College Dublin Philip J O'Connell, University College Dublin Brian O'Kelly, Dublin City University Sean O Riain, National University of Ireland Maynooth Andrea Prothero, University College Dublin William K Roche, University College Dublin Paul Teague, Queen's University, Belfast