Search

We have measured the cosmic ray spectrum at energies above $10^{17}$ eV using the two air fluorescence detectors of the High Resolution Fly's Eye experiment operating in monocular mode. We describe the detector, PMT and atmospheric calibrations, and the analysis techniques for the two detectors. We fit the spectrum to models describing galactic and extragalactic sources. Our measured spectrum gives an observation of a feature known as the ``ankle'' near $3\times 10^{18}$ eV, and strong evidence for a suppression near $6\times 10^{19}$ eV., Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted version

We present the results of a search for cosmic ray point sources at energies above 40 EeV in the combined data sets recorded by the AGASA and HiRes stereo experiments. The analysis is based on a maximum likelihood ratio test using the probability density function for each event rather than requiring an a priori choice of a fixed angular bin size. No statistically significant clustering of events consistent with a point source is found.

The composition of Ultra High Energy Cosmic Rays (UHECR) is measured with the High Resolution Fly's Eye cosmic ray observatory (HiRes) data using the Xmax technique. Data were collected in stereo between 1999 November and 2001 September. The data are reconstructed with well-determined geometry. Measurements of the atmospheric transmission are incorporated in the reconstruction. The detector resolution is found to be 30 g cm^-2 in Xmax and 13% in Energy. The Xmax elongation rate between 10^18.0 eV and 10^19.4 eV is measured to be 54.5 +/- 6.5 (stat) +/- 4.5 (sys) g cm^-2 per decade. This is compared to predictions using the QGSJet01 and SIBYLL 2.1 hadronic interaction models for both protons and iron nuclei. CORSIKA-generated Extensive Air Showers (EAS) are incorporated directly into a detailed detector Monte Carlo program. The elongation rate and the Xmax distribution widths are consistent with a constant or slowly changing and predominantly light composition. A simple model containing only protons and iron nuclei is compared to QGSJet and SIBYLL. The best agreement between the model and the data is at 80% protons for QGSJet and 60% protons for SIBYLL., Comment: 52 pages, 27 figures. Revised Fig. 10 caption, improved Fig. 23, resubmitted to ApJ. (Previously revised to address referee's comments.) (Originally 37 pages, 13 figures. Submitted to ApJ)

In the past few years, small scale anisotropy has become a primary focus in the search for source of Ultra-High Energy Cosmic Rays (UHECRs). The Akeno Giant Air Shower Array (AGASA) has reported the presence of clusters of event arrival directions in their highest energy data set. The High Resolution Fly's Eye (HiRes) has accumulated an exposure in one of its monocular eyes at energies above 10^(19.5) eV comparable to that of AGASA. However, monocular events observed with an air fluorescence detector are characterized by highly asymmetric angular resolution. A method is developed for measuring autocorrelation with asymmetric angular resolution. It is concluded that HiRes-I observations are consistent with no autocorrelation and that the sensitivity to clustering of the HiRes-I detector is comparable to that of the reported AGASA data set. Furthermore, we state with a 90% confidence level that no more than 13% of the observed HiRes-I events above 10^(19.5) eV could be sharing common arrival directions. However, because a measure of autocorrelation makes no assumption of the underlying astrophysical mechanism that results in clustering phenomena, we cannot claim that the HiRes monocular analysis and the AGASA analysis are inconsistent beyond a specified confidence level., Comment: 16 pages, 23 figures

The High Resolution Fly's Eye (HiRes) experiment is an air fluorescence detector which, operating in stereo mode, has a typical angular resolution of 06 and is sensitive to cosmic rays with energies above 1018 eV. The HiRes cosmic-ray detector is thus an excellent instrument for the study of the arrival directions of ultra-high-energy cosmic rays. We present the results of a search for anisotropies in the distribution of arrival directions on small scales ( 1019 eV). The search is based on data recorded between 1999 December and 2004 January, with a total of 271 events above 1019 eV. No small-scale anisotropy is found, and the strongest clustering found in the HiRes stereo data is consistent at the 52% level with the null hypothesis of isotropically distributed arrival directions.

The high resolution Fly’s Eye (HiRes) detector in Dugway, Utah, is an air fluorescence detector designed for the measurement of the energy and arrival direction of cosmic ray particles with energy E >10 18 eV. HiRes monitors the night sky for fluorescence light from air shower cascades induced by cosmic ray primaries. The light is collected by mirrors and projected onto arrays of photomultiplier tubes that provide an image of the air shower. HiRes is an astronomical instrument, and the accuracy of the mirror pointing and understanding of the optical properties of the mirror–camera units is crucial. We present a method to cross-check and monitor the mirror pointing by using star light. A star crossing the field of view of a photomultiplier tube causes a temporary increase in the total light detected by the tube. Using UV bright stars, we analyze the pointing accuracy of the HiRes 2 detector, and evaluate the shape of a point-like object as a function of distance to the mirror axis.

We study the spectrum and average mass composition of cosmic rays with primary energies between 10^{17} eV and 10^{18} eV using a hybrid detector consisting of the High Resolution Fly's Eye (HiRes) prototype and the MIA muon array. Measurements have been made of the change in the depth of shower maximum as a function of energy. A complete Monte Carlo simulation of the detector response and comparisons with shower simulations leads to the conclusion that the cosmic ray intensity is changing f rom a heavier to a lighter composition in this energy range. The spectrum is consistent with earlier Fly's Eye measurements and supports the previously found steepening near 4 \times 10^{17} eV .

The High-Resolution Fly's Eye (HiRes) is an observatory for the highest energy cosmic rays. It detects the nitrogen fluorescence light induced by the passage of giant cosmic ray extensive air showers through the atmosphere. A two-site prototype of the observatory was operated from September 1994 to November 1996. In this paper we describe the components of that detector, and the procedures used to calibrate the detector and characterise the atmosphere. Data collected by the HiRes prototype are being used for physics studies, including an analysis of the cosmic ray mass composition in the energy range from 1017 to 10 18 eV .

The average mass composition of cosmic rays with primary energies between ${10}^{17}$ and ${10}^{18}\mathrm{eV}$ has been studied using a hybrid detector consisting of the High Resolution Fly's Eye (HiRes) prototype and the MIA muon array. Measurements have been made of the change in the depth of shower maximum and the muon density as a function of energy. The results show that the composition is changing from a heavy to lighter mix as the energy increases.

The High Resolution Fly's Eye EHE cosmic ray detector (HiRes) was operated for over two years (prior to November 1996) in a two-site prototype configuration. This paper describes the development and testing of an event reconstruction method for extensive air showers (EAS) viewed in coincidence by both sites (stereo viewing). The reconstruction accuracy was directly measured through the use of a UV laser mounted on a telescope that generated airshower-like events with known geometries. For events observed with stereo opening angles greater than about 10° (most events) the median error in the reconstructed laser direction was 0.4° with 95% of events being reconstructed with errors of less than 0.9° (which degrade to 0.8° and 1.8°, respectively, for smaller opening angles). A limited investigation of the likely performance of the HiRes Stage 1.0 detector was undertaken. Reconstruction accuracy is likely to be only slightly degraded compared with the prototype results.

Stable, robust ultraviolet light sources for atmospheric monitoring and calibration pose a challenge for experiments that measure air #uorescence from cosmic ray air showers. One type of light source in use at the High Resolution Fly’s Eye (HiRes) cosmic ray observatory features a xenon #ashbulb at the focal point of a spherical mirror to produce a 1 ls pulse of collimated light that includes a strong UV component. A computer-controlled touch tone radio system provides remote operation of bulb triggering and window heating. These devices, dubbed ‘#ashersa, feature stand-alone operation, $5% shot-to-shot stability, weather proof construction and are well suited for long-term"eld use. This paper describes the #ashers, the radio control system, and a 12-unit array in operation at the HiRes cosmic ray observatory ( 1999 Elsevier Science B.V. All rights reserved.

In recent years the Fly's Eye and Akeno groups have presented analyses of the cosmic ray mass composition at energies above 10^17 eV. While the analysis of the Fly's Eye group points to a likely change in mass composition from heavy to light at energies above 10^18 eV, the Akeno analysis favours an unchanging composition. However, the two groups base their conclusions on simulations using quite different hadronic models. Here we present a comparison of the experiments using the same hadronic model and find that the agreement between the experiments is much improved. Under this model, both experiments measure a composition rich in iron around 10^17 eV which becomes lighter at higher energies. However, the agreement is not complete, which indicates scope for improvement of the interaction model, or perhaps the need for a re-examination of the experimental results., 15 pages, uses epsfig.sty with 6 figures. Submitted to Astroparticle Physics, 25th January 1998. This is a revised version (21st May 1998) which addresses some referee comments, and which clarifies discussions of our results

Patients with hepatitis C viral (HCV) may perceive barriers to accessing speciality care for HCV, and these barriers may be related to depressive symptoms.To evaluate the relationship between barriers to care, demographics, and depressive symptoms.A cross-sectional analysis of 126 patients referred for HCV at two speciality HCV clinics. Barriers to care, depressive symptoms and sociodemographics were measured using standardized instruments. A retrospective chart review was conducted to collect clinical outcome data.Depressive symptoms were reported in 26%. Common barriers included lack of personal financial resources; lack of HCV knowledge in the community; lack of professionals competent in HCV care; stigmatization of HCV; and long distances to clinics offering care. After we controlled for sociodemographics, depression accounted for an additional 7-18% of variability in all barriers (all p values0.01). Lower depression, marital and employment status were associated with subsequent receipt of HCV treatment in 38% (45/120) of patients; perceived barriers were not.Depression is independently associated with perceived barriers to care. Higher depressive scores, but not perceived barriers, were associated with nontreatment. Healthcare providers who diagnose HCV need to be cognizant of numerous perceived barriers to accessing HCV care, and the impact that depression may have on these perceptions and receipt of treatment.

Aliment Pharmacol Ther 2010; 32: 1163–1173 Summary Background Patients with hepatitis C viral (HCV) may perceive barriers to accessing speciality care for HCV, and these barriers may be related to depressive symptoms. Aim To evaluate the relationship between barriers to care, demographics, and depressive symptoms. Methods A cross-sectional analysis of 126 patients referred for HCV at two speciality HCV clinics. Barriers to care, depressive symptoms and sociodemographics were measured using standardized instruments. A retrospective chart review was conducted to collect clinical outcome data. Results Depressive symptoms were reported in 26%. Common barriers included lack of personal financial resources; lack of HCV knowledge in the community; lack of professionals competent in HCV care; stigmatization of HCV; and long distances to clinics offering care. After we controlled for sociodemographics, depression accounted for an additional 7–18% of variability in all barriers (all p values

Magnetic resonance (MR) imaging was performed in seven asymptomatic volunteers and 17 patients with clinical and radiologic evidence of sacroiliitis. MR imaging findings were compared with those at computed tomography (CT) to determine the MR imaging appearance of the sacroiliac joint when normal and in sacroiliitis. The normal articulation was well depicted with MR imaging. Findings of sacroiliitis were identified in 20 sacroiliac joints (12 patients). MR imaging findings characteristic of sacroiliitis included abnormal cartilage signal intensity (95% of joints) and erosions (75% of joints) on T1-weighted images. Areas of increased intensity in the articulation (80% of joints) or in erosions (60% of joints) were seen on T2-weighted images. MR imaging was superior to CT for evaluation of cartilage and detection of erosions. Four sacroiliac joints (20%) and two patients (17%) with MR imaging findings of sacroiliitis were negative at CT. The authors conclude that MR imaging is a valuable method for detecting sacroiliitis, particularly when results of other imaging techniques are inconclusive.

Peptides such as parathyroid hormone (PTH), somatostatin, and gastrin have been reported to stimulate mast cell mediator release. Preincubation of rat serosal mast cells with synthetic 1-34 bovine parathyroid hormone (1-34bPTH) significantly enhanced antigen-induced 5-hydroxytryptamine (5-HT) release. Enhancement of 5-HT release by 1-34bPTH was dose dependent between 5 and 2000 nM. In the absence of antigen, mean net 5-HT release was less than 1% when naive or passively sensitized mast cells were incubated with 1000 nM 1-34bPTH for time intervals up to 90 min. These findings indicate that 1-34bPTH, at relatively low concentration, potentiates antigen-induced 5-HT release from mast cells.

Summary Background Most research on the psychiatric symptoms of peginterferon/ribavirin for the treatment of hepatitis C comes from VA centres and clinical trials with rigid entry criteria that often excluded patients with markers of mental health and substance use disturbance (MH/SUD). The findings from these lines of research may not be generalizable to patients treated under standard of care in a tertiary care setting. Aim To investigate the incidence and outcomes of psychiatric symptoms in patients treated under standard of care protocol, not enrolled in clinical trials. Methods This is a retrospective analysis of 215 patients who underwent therapy from 2002 to 2006 at a university-based tertiary care centre. Survival curves explored the relationship between history of MH/SUD and the development of psychiatric symptoms on treatment. Results The cumulative history of MH/SUD was 67%. Of these, 39% had taken psychotropic medications previously, and 80% continued on them during therapy. On therapy, 46% developed depressive symptoms, 19% and 46% endorsed anxiety and irritability respectively. Cumulatively, 64% of patients indicated mood disturbance on therapy. Most symptoms developed between weeks 2 and 18, and rarely after week 20. Of those who developed mood symptoms, 66% required an intervention. Treatment discontinuation was infrequent. Conclusions This large observational study provides important insights into the incidence and course of psychiatric symptoms in an unselected sample of patients treated in a tertiary care setting. Patients had higher rates of MH/SUD comorbidity, psychotropic medication use and exhibit higher rates of mood disturbance on therapy compared with previous reports, although a majority completed the prescribed treatment regimen.

Several proposed source models for Ultra-High Energy Cosmic Rays (UHECRs) consist of dipole distributions oriented towards major astrophysical landmarks such as the galactic center, M87, or Centaurus A. We use a comparison between real data and simulated data to show that the HiRes-I monocular data for energies above 10^{18.5} eV is, in fact, consistent with an isotropic source model. We then explore methods to quantify our sensitivity to dipole source models oriented towards the Galactic Center, M87, and Centaurus A., Comment: 17 pages, 31 figures

We have measured the cosmic ray spectrum above 10^17.2 eV using the two air fluorescence detectors of the High Resolution Fly's Eye observatory operating in monocular mode. We describe the detector, photo-tube and atmospheric calibrations, as well as the analysis techniques for the two detectors. We fit the spectrum to a model consisting of galactic and extra-galactic sources., Comment: 4 pages, 4 figures. Uses 10pt.rtx, amsmath.sty, aps.rtx, revsymb.sty, revtex4.cls

We apply the perturbation theory integral representation (PTIR) to solve for the bound state Bethe-Salpeter (BS) vertex for an arbitrary scattering kernel, without the need for any Wick rotation. The results derived are applicable to any scalar field theory (without derivative coupling). It is shown that solving directly for the BS vertex, rather than the BS amplitude, has several major advantages, notably its relative simplicity and superior numerical accuracy. In order to illustrate the generality of the approach we obtain numerical solutions using this formalism for a number of scattering kernels, including cases where the Wick rotation is not possible., 28 pages of LaTeX, uses psfig.sty with 5 figures. Also available via WWW at http://www.physics.adelaide.edu.au/theory/papers/ADP-97-10.T248-abs.html or via anonymous ftp at ftp://bragg.physics.adelaide.edu.au/pub/theory/ADP-97-10.T248.ps A number of (crucial) typographical errors in Appendix C corrected. To be published in Phys. Rev. D, October 1997

The Bethe-Salpeter equation (BSE) for bound states in scalar theories is reformulated and solved in terms of a generalized spectral representation directly in Minkowski space. This differs from the conventional approach, where the BSE is solved in Euclidean space after a Wick rotation. For all but the lowest-order (i.e., ladder) approximation to the scattering kernel, the {\it naive} Wick rotation is invalid. Our approach generates the vertex function and Bethe-Salpeter amplitude for the entire allowed range of momenta, whereas these cannot be directly obtained from the Euclidean space solution. Our method is quite general and can be applied even in cases where the Wick rotation is not possible., Comment: 16 pages of LaTeX, uses epsfig.sty with 2 figures. Entire manuscript available as a ps file at http://www.physics.adelaide.edu.au/theory/home.html or ftp://adelphi.adelaide.edu.au/pub/theory/ADP-96-1.T206.ps

Recent studies have shown that the serum transferrin receptor is a sensitive, quantitative measure of tissue iron deficiency. This study was undertaken to determine the serum transferrin receptor's ability to distinguish iron-deficiency anemia from the anemia of chronic inflammation and to identify iron deficiency in patients with liver disease. The mean transferrin receptor level in 17 normal controls was 5.36 +/- 0.82 mg/L compared with 13.91 +/- 4.63 mg/L in 17 patients with iron-deficiency anemia (p less than 0.001). The mean serum receptor level was normal in all 20 patients with acute infection, including five with acute hepatitis, and was also normal in 8 of 10 anemic patients with chronic liver disease. Receptor levels were in the normal range in all but 4 of 41 patients with anemia of chronic disease. We conclude that unlike serum ferritin levels, which are disproportionately elevated in relation to iron stores in patients with inflammation or liver disease, the serum transferrin receptor level is not affected by these disorders and is therefore a reliable laboratory index of iron deficiency anemia.

A case of malignant mastocytosis with peripheral blood involvement is presented. The course of the patient's illness was complicated by recurrent hypotensive episodes, presumed to have been caused by mast cell degranulation. Treatment with hydroxyurea was associated with persistent hypotension which resulted in death. It has been proposed that the diagnosis of mast cell leukemia be given to patients presenting with greater than 10% atypical mast cells in the blood. However, review of 16 published cases of malignant mastocytosis with circulating mast cells reveals that the clinical manifestations, complications, and survival do not vary significantly with the percentage of peripheral blood mast cells. Patients with malignant mastocytosis with significant involvement by atypical mast cells in the bone marrow and peripheral blood should be considered as having an aggressive disease, regardless of the percentage of circulating mast cells.

The level of assimilation of dietary iron is believed to have an important influence on iron status. To examine the effect of enhancing the availability of dietary iron on iron balance, 17 adult volunteer subjects were given 2 g of ascorbic acid daily with meals for 16 weeks. Serum ferritin levels before and after the study averaged 46 and 43 micrograms/L, respectively, indicating a negligible effect on iron stores. When vitamin C supplementation was continued for an additional 20 months in five iron-replete and four iron-deficient subjects, serum ferritin determinations again failed to indicate any significant effect of the vitamin C on iron reserves. These findings were not explained by intestinal adaptation to the enhancing effect of the vitamin, because radioisotopic measurements of nonheme iron absorption showed no reduction in the enhancing effect of 1 g of ascorbic acid after four months of megadoses of vitamin C. It is concluded that altering the availability of nonheme dietary iron has little effect on iron status when the diet contains substantial amounts of meat.

Numerous η5-cyclopentadienyl derivatives of most of the transition metals are known.1 Over the past decade attention has been directed to transition metal complexes containing peralkylated η5-cyclopentadienyl groups, particularly those involving the pentamethylcyclopentadienyl ligand.2–6 Such complexes usually possess, when compared to the relevant cyclopentadienyl analogs, properties reflecting their increased bulk and steric character, e.g., enhanced oxidative, reductive and thermal stability, coupled with reduced volatility. These peralkylated complexes have proved to be more easily isolable and their chemical reactivity and catalytic activity more amenable to study.

A patient with rheumatoid arthritis presented with pancytopenia 3 weeks after initiation of low-dose methotrexate administered orally. She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently. Bone marrow recovery occurred within 3 weeks. Patients receiving low-dose methotrexate therapy for rheumatoid arthritis require early monitoring for bone marrow injury, especially those who have risk factors for possible methotrexate toxicity.

The osteopetrotic, microphthalmic (mi/mi) mouse lacks functional osteoclasts and has also been reported to be deficient in mast cells and natural-killer (NK) cells. The later deficiencies could be secondary to the osteopetrotic marrow, or a direct result of the mi allele. Therefore, heterozygotes were examined for these cell types, since these mice do not exhibit osteopetrosis. Adult +/mi animals have approximately 50%, and mi/mi animals examined by histologic techniques or tissue histamine levels have 0-10%, of the peritoneal, dermal, and intestinal mast cells compared with that of +/+ animals. Leukocyte histamine, indicative of the number of basophils, demonstrates the same pattern. Histamine content per mast cell in +/+ and +/mi animals is identical. The number of large granular lymphocytes (LGL) in splenic leukocyte preparations from +/mi animals is 50% that of +/+ animals, and these cells are undetectable in preparations from mi/mi mice. NK activity against YAC-1 cells paralleled the number of LGL present. The resorptive response of neonatal calvaria to parathyroid hormone was delayed in the case of cultured +/mi bone compared with that of +/+ bone, but the final rate of calcium release was identical. These data indicate that 1) the presence of one mi allele can affect the development of four distinct cell types, and 2) osteopetrosis alone does not account for the lack of mast cells, basophils, and NK cells in mi/mi mice.

The effect of mast cells and mast cell granules on macrophage O2- release as determined by cytochrome c reduction was studied. In vitro activation of mast cells before macrophage activation caused a decrease in O2- -mediated cytochrome c reduction. This decrease was proportional to mast cell activation and reached 80% to 100% when mast cell mediator release was 40% to 50%. Incubation of isolated mast cell granules with macrophages before activation also inhibited O2- -mediated cytochrome c reduction in a dose-dependent manner. Mast cell granule-mediated inhibition of cytochrome c reduction was not caused by histamine, serotonin, or any other dialyzable components but was found to be caused by the scavenging of O2- by mast cell granule-bound superoxide dismutase. Macrophage uptake of sulfur 35-labeled mast cell granules, electron microscopic localization of mast cell granules in the macrophage phagosomes, and the abrogation of mast cell granule effect when the cells were preincubated at 0 degree C indicate that the effect was associated with the adherence or phagocytosis (or both) of mast cell granules. These results suggest that mast cell granules interact with macrophages and that granule superoxide dismutase scavenges O2- generated by the phagocytes.

The successful application of the principle of phase stability 12 to a cyclotron has been reported from this Laboratory3. The satisfactory results of these experiments, performed on the 37-inch cyclotron, led to the decision to complete the 184-inch cyclotron then under construction as a frequency modulated machine. It ia the purpose of this note to describe briefly the equipment and experiments by which deuteron and alpha-particle beams of approximately 200 and 400 Mev, respectively, have been produced. The angular velocity of such ions in a magnetic field decreases by 11 percent because of the relativistic increase in mass during acceleration. In addition, a radial decrease of magnetic field, essentially linear from the center of a value of 95.4 percent of the central field at a radius of 80 inches, is provided to focus the ion beam properly. This field shape is produced by shims inside the vacuum chamber with contours empirically determined through measurements on a scale model. Thus a total minimum frequency variation of 16 percent is required; in practice it is desirable to provide a substantially greater frequency variation to insure that a satisfactory shape of the frequency vs. time curve is obtainable and to make adjustments less critical. E.M. McMillan, Phys. Rev. 68, 143 (1945). V. Veksler, J. Phys. U.S.S.R. 9, 153 (1945). J.R. Richardson, K.R. MacKenzie, E.J. Lofgren, and B.T. Wright, Phys. Rev. 69, 669 (1946).