Search

Your search keyword '"K. Lung"' showing total 114 results
Start Over Author "K. Lung"
114 results on '"K. Lung"'

1. B03 CARFILZOMIB AND LENALIDOMIDE FOR PRIMARY PLASMA CELL LEUKEMIA: FINAL RESULTS OF THE PROSPECTIVE PHASE 2 EMN12/HOVON-129 STUDY FOR PATIENTS AGED ≥66 YEARS

Author

P. Musto, M.C. Minnema, W.W.H. Roeloffzen, A. Capra, B. van der Holt, A. Juul Vangsted, A. Broyl, F. Schjesvold, T. Lund, T. Silkjaer, R. Benjamin, M. Grasso, K. Lung Wu, J. Caers, M. Cavo, R. Hájek, B. Bruno, A. Gadisseur, G. Pietrantuono, M. Offidani, L. Pour, P. Sonneveld, M. Boccadoro, and N. van de Donk

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
Full Text
View/download PDF

2. Enhancing the Physical, Antimicrobial, and Osteo/Odontogenic Properties of a Sol–Gel-Derived Tricalcium Silicate by Graphene Oxide for Vital Pulp Therapies

Author

Mohamed Mahmoud Abdalla, Mohammed Zahedul Islam Nizami, Vidhyashree Rajasekar, Mohammed Basabrain, Christie Y. K. Lung, and Cynthia Kar Yung Yiu

Subjects
sol–gel, tricalcium silicate, graphene oxide, vital pulp therapy, human dental pulp stem cells, Biotechnology, TP248.13-248.65, Medicine (General), R5-920
Abstract

Objectives: This study developed a sol–gel tricalcium silicate/graphene oxide (TCS-GO) composite and examined its physicochemical properties, antimicrobial activity, and osteo/odontogenic effect on dental pulp stem cells. Methods: Tricalcium silicate was synthesized and combined with graphene oxide at three different concentrations, namely 0.02%, 0.04%, and 0.08% w/w, while tricalcium silicate and mineral trioxide aggregate served as controls. The setting time, compressive strength, pH, and calcium ion release of the composites were evaluated, as well as antimicrobial properties against Streptococcus mutans and Lactobacillus acidophilus. Additionally, the viability of dental pulp stem cells; apatite forming ability; and the gene expression of Alkaline phosphatase, Dentin sialophosphoprotein, and Runt-related transcription factor 2 were assessed. Results: TCS-GO (0.08%) showed a significantly shorter setting time and higher compressive strength when compared to MTA (p < 0.05). Additionally, tricalcium silicate and TCS-GO groups showed a higher release of Ca ions than MTA, with no significant difference in pH values among the different groups. TCS-GO (0.08%) also demonstrated a significantly stronger antimicrobial effect against Lactobacillus acidophilus compared to MTA (p < 0.05). ALP expression was higher in TCS-GO (0.08%) than MTA on days 3 and 7, while DSPP expression was higher in TCS-GO (0.08%) than MTA on day 3 but reversed on day 7. There was no significant difference in RUNX2 expression between TCS-GO (0.08%) and MTA on days 3 and 7. Conclusions: The TCS-GO (0.08%) composite demonstrated superior physicochemical characteristics and antimicrobial properties compared to MTA. Moreover, the early upregulation of ALP and DSPP markers in TCS-GO (0.08%) indicates that it has the potential to promote and enhance the osteo/odontogenic differentiation of DPSCs.

Published
2024
Full Text
View/download PDF

3. Physicochemical Properties and Inductive Effect of Calcium Strontium Silicate on the Differentiation of Human Dental Pulp Stem Cells for Vital Pulp Therapies: An In Vitro Study

Author

Mohamed Mahmoud Abdalla, Christie Y. K. Lung, Mohammed Nadeem Bijle, and Cynthia Kar Yung Yiu

Subjects
calcium strontium silicate, setting time, bioactivity, dental pulp stem cells, sol–gel, differentiation, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract

The development of biomaterials that exhibit profound bioactivity and stimulate stem cell differentiation is imperative for the success and prognosis of vital pulp therapies. The objectives were to (1) synthesize calcium strontium silicate (CSR) ceramic through the sol–gel process (2) investigate its physicochemical properties, bioactivity, cytocompatibility, and its stimulatory effect on the differentiation of human dental pulp stem cells (HDPSC). Calcium silicate (CS) and calcium strontium silicate (CSR) were synthesized by the sol–gel method and characterized by x-ray diffraction (XRD). Setting time, compressive strength, and pH were measured. The in vitro apatite formation was evaluated by SEM-EDX and FTIR. The NIH/3T3 cell viability was assessed using an MTT assay. The differentiation of HDPSC was evaluated using alkaline phosphatase activity (ALP), and Alizarin red staining (ARS). Ion release of Ca, Sr, and Si was measured using inductive coupled plasma optical emission spectroscopy (ICP-OES). XRD showed the synthesis of (CaSrSiO4). The initial and final setting times were significantly shorter in CSR (5 ± 0.75 min, 29 ± 1.9 min) than in CS (8 ± 0.77 min, 31 ± 1.39 min), respectively (p < 0.05). No significant difference in compressive strength was found between CS and CSR (p > 0.05). CSR demonstrated higher apatite formation and cell viability than CS. The ALP activity was significantly higher in CSR 1.16 ± 0.12 than CS 0.92 ± 0.15 after 14 d of culture (p < 0.05). ARS showed higher mineralization in CSR than CS after 14 and 21 d culture times. CSR revealed enhanced differentiation of HDPSC, physicochemical properties, and bioactivity compared to CS.

Published
2022
Full Text
View/download PDF

4. Krüppel-like factor 2 is required for normal mouse cardiac development.

Author

Aditi R Chiplunkar, Tina K Lung, Yousef Alhashem, Benjamin A Koppenhaver, Fadi N Salloum, Rakesh C Kukreja, Jack L Haar, and Joyce A Lloyd

Subjects
Medicine, Science
Abstract

Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death by mouse embryonic day 14.5 (E14.5) in a mixed genetic background. This work identifies an earlier and more fundamental role for KLF2 in mouse cardiac development in FVB/N mice. FVB/N KLF2-/- embryos die earlier, by E11.5. E9.5 FVB/N KLF2-/- hearts have multiple, disorganized cell layers lining the AV cushions, the primordia of the AV valves, rather than the normal single layer. By E10.5, traditional and endothelial-specific FVB/N KLF2-/- AV cushions are hypocellular, suggesting that the cells accumulating at the AV canal have a defect in endothelial to mesenchymal transformation (EMT). E10.5 FVB/N KLF2-/- hearts have reduced glycosaminoglycans in the cardiac jelly, correlating with the reduced EMT. However, the number of mesenchymal cells migrating from FVB/N KLF2-/- AV explants into a collagen matrix is reduced considerably compared to wild-type, suggesting that the EMT defect is not due solely to abnormal cardiac jelly. Echocardiography of E10.5 FVB/N KLF2-/- embryos indicates that they have abnormal heart function compared to wild-type. E10.5 C57BL/6 KLF2-/- hearts have largely normal AV cushions. However, E10.5 FVB/N and C57BL/6 KLF2-/- embryos have a delay in the formation of the atrial septum that is not observed in a defined mixed background. KLF2 ablation results in reduced Sox9, UDP-glucose dehydrogenase (Ugdh), Gata4 and Tbx5 mRNA in FVB/N AV canals. KLF2 binds to the Gata4, Tbx5 and Ugdh promoters in chromatin immunoprecipitation assays, indicating that KLF2 could directly regulate these genes. In conclusion, KLF2-/- heart phenotypes are genetic background-dependent. KLF2 plays a role in EMT through its regulation of important cardiovascular genes.

Published
2013
Full Text
View/download PDF

5. Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1

Author

Rebecca Reese, David K. Lung, and Elaine T. Alarid

Subjects
0301 basic medicine, Male, Cancer Research, Endocrinology, Diabetes and Metabolism, Systems biology, Estrogen receptor, Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Gene expression, Transcriptional regulation, Humans, Transcription factor, Cell Proliferation, Endocrine and Autonomic Systems, Estrogen Receptor alpha, Chromatin, Cell biology, body regions, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, Signal transduction, Estrogen receptor alpha
Abstract

Transcriptional regulation of ESR1, the gene that encodes for estrogen receptor α (ER), is critical for regulating the downstream effects of the estrogen signaling pathway in breast cancer such as cell growth. ESR1 is a large and complex gene that is regulated by multiple regulatory elements, which has complicated our understanding of how ESR1 expression is controlled in the context of breast cancer. Early studies characterized the genomic structure of ESR1 with subsequent studies focused on identifying intrinsic (chromatin environment, transcription factors, signaling pathways) and extrinsic (tumor microenvironment, secreted factors) mechanisms that impact ESR1 gene expression. Currently, the introduction of genomic sequencing platforms and additional genome-wide technologies has provided additional insight on how chromatin structures may coordinate with these intrinsic and extrinsic mechanisms to regulate ESR1 expression. Understanding these interactions will allow us to have a clearer understanding of how ESR1 expression is regulated and eventually provide clues on how to influence its regulation with potential treatments. In this review, we highlight key studies concerning the genomic structure of ESR1, mechanisms that affect the dynamics of ESR1 expression, and considerations towards affecting ESR1 expression and hormone responsiveness in breast cancer.

Published
2020

6. Influenza vaccination status and outcomes among influenza-associated hospitalizations in Columbus, Ohio (2012–2015)

Author

Claire E. Bollinger, L. Tatham, Julie K. Bower, Joseph H. Tien, Paul N. Zivich, and K. Lung

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Adolescent, Epidemiology, Influenza vaccination status, Influenza vaccine, 030106 microbiology, Severe influenza, Logistic regression, Virus, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Influenza, Human, medicine, Humans, 030212 general & internal medicine, Child, Intensive care medicine, Aged, Ohio, Retrospective Studies, business.industry, Infant, virus diseases, Pneumonia, Middle Aged, medicine.disease, Original Papers, Hospitalization, Vaccination, Logistic Models, Treatment Outcome, Infectious Diseases, Influenza Vaccines, Human mortality from H5N1, Female, Seasons, business
Abstract

SUMMARYPrior studies suggest that the influenza vaccine is protective against some outcomes in hospitalized patients infected with influenza despite vaccination. We utilized surveillance data from Columbus, Ohio to investigate this association over multiple influenza seasons and age groups. Data on laboratory-confirmed influenza-associated hospitalizations were collected as a part of the Influenza Hospitalization Surveillance Project for the 2012–2013, 2013–2014, and 2014–2015 influenza seasons. The association between influenza vaccination status was examined in relation to the outcomes of severe influenza and diagnosis of pneumonia among patients receiving antiviral treatment. Data were analyzed using multivariable logistic regression. We observed no overall association between influenza vaccination status and severe influenza among hospitalized patients. During the 2013–2014 season, those who were vaccinated were 41% less likely to be diagnosed with pneumonia compared with those who were unvaccinated (OR = 0·59 95% CI 0·41–0·86). The influenza vaccine may provide a secondary preventive function against pneumonia among influenza cases requiring hospitalization. However, a protective effect was only observed in 2013–2014, an influenza H1N1 dominant year. Differences in circulating influenza virus strains and vaccine matching to the circulating strains during influenza seasons may impact this association.

Published
2017

7. Bone Marrow Stromal Cells Transcriptionally Repress ESR1 but Cannot Overcome Constitutive ESR1 Mutant Activity

Author

Shigeki Miyamoto, Christina J Mark, Peiman Hematti, Elaine T. Alarid, Natalie S. Callander, Jay W. Warrick, and David K. Lung

Subjects
0301 basic medicine, MAPK/ERK pathway, Cell type, medicine.medical_specialty, Stromal cell, Transcription, Genetic, Estrogen receptor, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Downregulation and upregulation, Internal medicine, medicine, Humans, RNA, Messenger, Research Articles, Regulation of gene expression, Mitogen-Activated Protein Kinase Kinases, Chemistry, Estrogen Receptor alpha, Mesenchymal Stem Cells, Cell biology, body regions, 030104 developmental biology, Gene Expression Regulation, Cell culture, 030220 oncology & carcinogenesis, Mutation, MCF-7 Cells, Estrogen receptor alpha, Protein Processing, Post-Translational
Abstract

Estrogen receptor α (ER) is the target of endocrine therapies in ER-positive breast cancer (BC), but their therapeutic effectiveness diminishes with disease progression. Most metastatic BCs retain an ER-positive status, but ER expression levels are reduced. We asked how the bone tumor microenvironment (TME) regulates ER expression. We observed ESR1 mRNA and ER protein downregulation in BC cells treated with conditioned media (CM) from patient-derived, cancer-activated bone marrow stromal cells (BMSCs) and the BMSC cell line HS5. Decreases in ESR1 mRNA were attributed to decreases in nascent transcripts as well as decreased RNA polymerase II occupancy and H3K27Ac levels on the ESR1 promoter and/or distal enhancer (ENH1). Repression extended to neighboring genes of ESR1, including ARMT1 and SYNE1. Although ERK/MAPK signaling pathway can repress ER expression by other TME cell types, MAPK inhibition did not reverse decreases in ER expression by BMSC-CM. ESR1 mRNA and ER protein half-lives in MCF7 cells were unchanged by BMSC-CM treatment. Whereas ER phosphorylation was induced, ER activity was repressed by BMSC-CM as neither ER occupancy at known binding sites nor estrogen response element–luciferase activity was detected. BMSC-CM also repressed expression of ER target genes. In cells expressing the Y537S and D538G ESR1 mutations, BMSC-CM reduced ESR1, but expression of target genes PGR and TFF1 remained significantly elevated compared with that of control wild-type cells. These studies demonstrate that BMSCs can transcriptionally corepress ESR1 with neighboring genes and inhibit receptor activity, but the functional consequences of the BMSC TME can be limited by metastasis-associated ESR1 mutations.

Published
2019

8. Effect of temperatures and loading rates on direct shear strength of asphaltic concrete using layer-parallel direct shear test

Author

Sharvin Poovaneshvaran, P. J. Ramadhansyah, Meor Othman Hamzah, Ashiru Sani, C. K. Lung, and Mohd Rosli Mohd Hasan

Subjects
Materials science, Public work, 0211 other engineering and technologies, Resilient modulus, Stiffness, 020101 civil engineering, 02 engineering and technology, 0201 civil engineering, Asphalt, 021105 building & construction, medicine, Loading rate, Shear strength, Direct shear test, medicine.symptom, Composite material, Layer (electronics)
Abstract

This paper evaluates the influence of temperatures and loading rates on the shear strength of dense asphalt (AC14) prepared based on the Malaysian Public Works Department specification. In this study, different specimen conditioning temperatures, 10°C, 20°C, 30°C, and loading rates of 20.88mm/min, 40.88mm/min, 50.88mm/min, and 60.8mm/min were used to assess the performance of specimens by using Layer-Parallel Direct Shear (LPDS) test. Based on the results, both parameters have significant effects on the shear strength of the asphalt specimens. The results indicate that the loading rate is directly proportional to the shear strength of asphalt specimens. It is because the stiffness of the asphalt mix increases as the loading rate increases. Hence, it enhanced the shear strength of asphalt specimens. On the other hand, the temperature is inversely proportional to the shear strength of asphalt mixes. As the temperature increases, the stiffness of the asphalt mixture reduces due to the lower resilient modulus; therefore, it reduces the shear strength of the specimen.

Published
2020

9. Canadian Surgery Forum 2018: St. John’s, NL Sept. 13–15, 2018

Author

S, Jayaraman, L, Lee, J, Mata, R, Droeser, P, Kaneva, S, Liberman, P, Charlebois, B, Stein, G, Fried, L, Feldman, M, Schellenberg, K, Inaba, V, Cheng, J, Bardes, L, Lam, E, Benjamin, K, Matsushima, D, Demetriades, J, Cho, A, Strumwasser, D, Grabo, C, Bir, A, Eastman, N, Orozco, J, Chen, C, Park, T, Kang, J, Jung, J, Elfassy, T, Grantcharov, J, Taylor, M, Stem, D, Yu, S, Chen, S, Fang, S, Gearhart, B, Safar, J, Efron, P, Serrano, S, Parpia, D, McCarty, N, Solis, M, Valencia, S, Jibrael, A, Wei, S, Gallinger, M, Simunovic, A, Hummadi, M, Rabie, M, Al Skaini, H, Shamshad, S, Shah, K, Verhoeff, P, Glen, A, Taheri, B, Min, B, Tsang, V, Fawcett, S, Widder, M, Yang, K, Wanis, O, Gilani, K, Vogt, M, Ott, J, VanKoughnett, C, Vinden, S, Balvardi, E, St Louis, Y, Yousef, A, Toobaie, E, Guadagno, R, Baird, D, Poenaru, A, Kleiman, B, Mador, C, Moulton, E, Lee, C, Li, K, Beyfuss, H, Solomon, N, Sela, V, McAlister, A, Ritter, J, Hallet, M, Tsang, G, Martel, D, Jalink, M, Husien, C, Gu, M, Levine, S, Otiti, J, Nginyangi, C, Yeo, J, Ring, M, Holden, T, Ungi, G, Fichtinger, B, Zevin, B, Fang, J, Dang, S, Karmali, M, Kim, B, Zhang, E, Duceppe, S, Rieder, A, Maeda, A, Okrainec, T, Jackson, F, Kegel, S, Lachance, T, Landry, C, Mueller, S, Joharifard, E, Nyiemah, C, Howe, C, Dobboh, L Gizzie, Kortimai, A, Kabeto, J, Beste, N, Garraway, R, Riviello, S, Hameed, S, Shinde, G, Marcil, S, Prasad, J, Arminan, E, Debru, N, Church, R, Gill, P, Mitchell, M, Delisle, C, Chernos, J, Park, K, Hardy, A, Vergis, M, Guez, D, Hong, J, Koichopolos, R, Hilsden, D, Thompson, F, Myslik, J, Vandeline, R, Leeper, A, Doumouras, S, Govind, S, Valanci, N, Alhassan, T, Wong, N, Nadkarni, S, Chia, D, Seow, D, Carter, L, Ruo, O, Levine, L, Allen, P, Murphy, R, van Heest, F, Saleh, S, Minor, P, Engels, E, Joos, C, Wang, R, Nenshi, M, Meschino, C, Laane, N, Parry, M, Hameed, A, Lacoul, C, Chrystoja, J, Ramjist, R, Sutradhar, L, Lix, N, Baxter, D, Urbach, J, Ahlin, S, Patel, S, Nanji, S, Merchant, K, Lajkosz, S, Brogly, P, Groome, J, Sutherland, G, Liu, T, Crump, M, Bair, A, Karimuddin, A, Peterson, J, Hawel, E, Shlomovitz, I, Habaz, A, Elnahas, N, Alkhamesi, C, Schlachta, G, Akhtar-Danesh, T, Daodu, V, Nguyen, R, Dearden, I, Datta, L, Hampton, A, Kirkpatrick, J, McKee, J, Regehr, P, Brindley, D, Martin, A, LaPorta, L, Gillman, K, DeGirolamo, K, D'Souza, L, Hartford, D, Gray, C, Clarke, R, Wigen, C, Garcia-Ochoa, S, Gray, A, Maciver, J, Van Koughnett, K, Leslie, T, Zwiep, S, Ahn, J, Greenberg, F, Balaa, D, McIsaac, R, Musselman, I, Raiche, L, Williams, H, Moloo, M, Nguyen, D, Naidu, P, Karanicolas, A, Nadler, R, Raskin, V, Khokhotva, R, Poirier, C, Plourde, A, Paré, M, Marchand, M, Leclair, J, Deshaies, P, Hebbard, I, Ratnayake, K, Decker, E, MacIntosh, Z, Najarali, A, Alhusaini, A, McClure, M, Dakouo, R, Behman, A, Nathens, N Look, Hong, P, Pechlivanoglou, K, Lung, P, Simone, E, Schemitsch, L, Chen, L, Rosenkrantz, N, Schuurman, R, George, E, Shavit, A, Pawliwec, Z, Rana, D, Evans, P, Dawe, R, Brown, G, Lefebvre, K, Devenny, D, Héroux, C, Bowman, R, Mimeault, L, Calder, L, Baker, R, Winter, C, Cahill, D, Fergusson, T, Schroeder, K, Kahnamoui, S, Elkheir, F, Farrokhyar, B, Wainman, O, Hershorn, S, Lim, A, Arora, F, Wright, J, Escallon, L, Gotlib, M, Allen, N, Gawad, I, Raîche, G, Jeyakumar, D, Li, M, Aarts, A, Giles, T, Dumitra, R, Alam, J, Fiore, M, Vassiliou, O, Al Busaidi, A, Brobbey, T, Stelfox, T, Chowdhury, J, Kortbeek, C, Ball, N, AlShahwan, S, Fraser, A, Tran, A, Martel, N, Manhas, D, Mannina, A, Behman, B, Haas, A, Fowler, L, Findlay-Shirras, H, Singh, N, Biswanger, A, Gosselin-Tardif, M Abou, Khalil, J Mata, Gutierrez, A, Guigui, L, Ferri, D, Roberts, L, Moore, J, Holcomb, J, Harvin, J, Sadek, P, Belanger, K, Nadeau, K, Mullen, D, Aitkens, K, Foss, D, MacIsaac, S, Zhang, M, Methot, L, Hookey, J, Yates, I, Perelman, E, Saidenberg, S, Khair, J, Lampron, A, Tinmouth, S, Hammond, D, Hochman, M, Lê, R, Rabbani, A, Abou-Setta, R, Zarychanski, B, Elsoh, B, Goldacre, G, Nash, M, Trepanier, N, Wong-Chong, C, Sabapathy, P, Chaudhury, N, Bradley, C, Dakin, N, Holm, W, Henderson, M, Roche, A, Sawka, E, Tang, B, Huang, T, Gimon, R, Rochon, M, Lipson, W, Buie, A, MacLean, E, Lau, V, Mocanu, I, Tavakoli, N, Switzer, C, Tian, C, de Gara, D, Birch, P, Young, C, Chiu, A, Meneghetti, G, Warnock, M, Meloche, O, Panton, A, Istl, A, Gan, P, Colquhoun, R, Habashi, S, Stogryn, J, Metcalfe, K, Clouston, N, Zondervan, K, McLaughlin, J, Springer, J, Lee, N, Amin, M, Caddedu, C, Eskicioglu, A, Warraich, D, Keren, N, Kloos, S, Gregg, R, Mohamed, E, Dixon, R, Rochan, A, Domouras, S, Kelly, I, Yang, S, Forbes, R, Garfinkle, S, Bhatnagar, G, Ghitulescu, C, Vasilevsky, N, Morin, M, Boutros, A, Petrucci, P, Sylla, S, Wexner, G, Sigler, J, Faria, P, Gordon, L, Azoulay, A, Liberman, S, Khorasani, A, de Buck van Overstraeten, E, Kennedy, N, Pecorelli, D, Mouldoveanu, A, Gosselin-Tardiff, J, Chau, F Rouleau, Fournier, P, Bouchard, J Abou, Khalil, J, Motter, J, Mottl, G, Hwang, J, Kelly, G, Nassif, M, Albert, J, Monson, J, McLeod, J, Cha, M, Raval, T, Phang, C, Brown, R, Robertson, F, Letarte, A, Antoun, V, Pelsser, E, Hyun, K, Clouston-Chambers, R, Helewa, S, Candy, Z, Mir, N, Hanna, A, Azin, D, Hirpara, F, Quereshy, C, O'Brien, S, Chadi, S, Punnen, H, Yoon, W, Xiong, H, Stuart, J, Andrews, R, Selvam, S, Wong, W, Hopman, P, MacDonald, F, Dossa, B, Medeiros, C, Keng, S, Acuna, J, Hamid, A, Ghuman, N, Kasteel, D, Buie, T, McMullen, A, Elwi, T, MacLean, H, Wang, F, Coutinho, Q, Le, L, Shack, H, Roy, R, Kennedy, J, Bunn, W, Chung, M, Elmi, E, Wakeam, R, Presutti, S, Keshavjee, T, Cil, D, McCready, V, Cheung, C, Schieman, J, Bailey, G, Nelson, T, Batchelor, S, Grondin, A, Graham, N, Safieddine, S, Johnson, W, Hanna, D, Low, A, Seely, E, Bedard, C, Finley, R, Nayak, D, Lougheed, D, Petsikas, A, Kinio, V Ferreira, Resende, C, Anstee, D, Maziak, S, Gilbert, F, Shamji, S, Sundaresan, P, Villeneuve, J, Ojah, A, Ashrafi, A, Najjar, I, Yamani, S, Sersar, A, Batouk, D, Parente, A, Laliberte, M, McInnis, C, McDonald, Y, Hasnain, K, Yasufuku, T, Waddell, N, Chopra, C, Nicholson-Smith, R, Malthaner, R, Patel, M, Doubova, H, Robaidi, E, Delic, A, Fazekas, K, Hughes, P, Pinkney, Y, Lopez-Hernandez, M, Coret, L, Schneider, J, Agzarian, Y, Shargall, M, Mehta, K, Pearce, V, Gupta, N, Coburn, B, Kidane, K, Hess, C, Compton, J, Ringash, G, Darling, A, Mahar, P, Thomas, J, Vernon, J, Spicer, S, Renaud, J, Seitlinger, Y, Al Lawati, F, Guerrera, P, Falcoz, G, Massard, D, Hylton, J, Huang, S, Turner, D, French, C, Wen, J, Masters, C, Fahim, D, St-Pierre, E, Ruffini, M, Inra, Z, Abdelsattar, S, Cassivi, F, Nichols, D, Wigle, S, Blackmon, K, Shen, S, Gowing, F Sadegh, Beigee, K, Sheikhy, A Abbasi, Dezfouli, T, Schnurr, L, Linkins, M, Crowther, M, de Perrot, S, Uddin, J, Douketis, L, Angka, A, Jeong, M, Sadiq, M, Kilgour, C Tanese, de Souza, M, Kennedy, R, Auer, R, Adam, R, Memeo, D, Goéré, T, Piardi, E, Lermite, O, Turrini, M, Lemke, J, Li, M, Tun-Abraham, R, Hernandez-Alejandro, S, Bennett, F, Navarro, A, Sa Cunha, P, Pessaux, E, Isenberg-Grzeda, J, Kazdan, S, Myrehaug, S, Singh, D, Chan, C, Law, C, Nessim, G, Paull, A, Ibrahim, E, Sabri, S, Rodriguez-Qizilbash, D, Berger-Richardson, R, Younan, J, Hétu, S, Johnson-Obaseki, F, Angarita, Y, Zhang, A, Govindarajan, E, Taylor, Z, Bayat, D, Bischof, A, McCart, S, Sequeira, S, Samman, S, Cornacchi, G, Foster, L, Thabane, S, Thomson, O, Lovrics, S, Martin, P, Lovrics, N, Latchana, L, Davis, Y, Liu, A, Hammad, D, Kagedan, C, Earle, G, Pang, S, Kupper, M, Quan, R, Hsiao, P, Bongers, M, Lustgarten, D, Goldstein, P, Dhar, L, Rotstein, J, Pasternak, J, Nostedt, L, Gibson-Brokop, M, McCall, D, Schiller, S, Mukhi, L, Mack, N, Singh, M, Chanco, A, Hilchie-Pye, C, Kenyon, A, Mathieson, J, Burke, R, Nason, J, Austin, M, Brar, S, Hurton, S, Kong, Y, Xu, M, Thibedeau, W, Cheung, J, Dort, S, Karim, A, Bouchard-Fortier, Y, Jeong, Q, Li, L, Bubis, C, O'Rourke, N, Dharampal, K, Smith, A, Harvey, R, Pashcke, L, Rudmik, S, Chandarana, S, Buac, S, Latosinsky, N, Shahvary, M, Gervais, G, Leblanc, M, Brackstone, K, Guidolin, B, Yaremko, S, Gaede, K, Lynn, A, Kornecki, G, Muscedere, O, Shmuilovich, I, BenNachum, M, Mouawad, N, Gelman, M, Lock, J, Daza, M, Horkoff, F, Sutherland, O, Bathe, M, Moser, J, Shaw, G, Beck, Y, Luo, S, Ahmed, C, Wall, T, Domes, K, Jana, E, Waugh, J, Baird, P, Newell, P, Hansen, M, Gough, E, McArthur, A, Skaro, G, Gauvin, N, Goel, D, Mutabdzic, F, Lambreton, M, Kilcoyne, K, Ang, A, Karachristos, H, Cooper, J, Hoffman, S, Reddy, L, Park, R, Gilbert, R, Shorr, A, Workneh, K, Bertens, J, Abou-Khalil, H, Smith, J, Levy, J, Ellis, B, Bakanisi, M, Sadeghi, S, Michaelson, V, Tandan, M, Marcaccio, D, Dath, M, Connell, A, Bennett, N, Wasey, R, Sorial, S, Macdonald, D, Johnson, D, Klassen, C, Leung, C, Botkin, M, Bahasadri, S, MacLellan, J, Tan, H, Jun, H, Cheah, K, Wong, N, Harvey, A, Smith, S, Cassie, S, Sun, J, Vallis, L, Twells, K, Lester, D, Gregory, W, Sun, F, Raghavji, M, Laffin, J, Bourget-Murray, A, Reso, A, Jarrar, N, Eipe, A, Budiansky, C, Walsh, J, Mamazza, and M, Rashid

Subjects
Abstracts
Published
2018

10. 2015 Canadian Surgery Forum02 The usefulness and costs of routine contrast studies after laparoscopic sleeve gastrectomy for detecting staple line leaks03 The association of change in body mass index and health-related quality of life in severely obese patients04 Inpatient cost of bariatric surgery within a regionalized centre of excellence system05 Regional variations in the public delivery of bariatric surgery: an evaluation of the centre of excellence model06 The effect of distance on short-term outcomes after bariatric surgery07 The role of preoperative upper endoscopy in bariatric surgery: a systematic review08 Outcomes of a dedicated bariatric revision surgery clinic10 Quality of follow-up: a systematic review of the research in bariatric surgery14 Bariatric surgery improves weight loss and cardiovascular disease compared with medical management alone: an Alberta multi-institutional early outcomes study16 Diabetic control after laparoscopic gastric bypass and sleeve gastrectomy: a short-term prospective study17 Knowledge and perception of bariatric surgery among primary care physicians: a survey of family doctors in Ontario19 Is early discharge of patients post laparoscopic sleeve gastrectomy safe?22 A comparison of outcomes between bariatric centres of excellence within Ontario02 Closure methods for laparotomy incisions: a cochrane review03 Closing the audit cycle: Are we consenting correctly now?05 Regional variation in the use of surgery in Ontario06 Quitting general surgery residency: attitudes and factors in Canada07 Nipple-sparing mastectomy: utility of intraoperative frozen section analysis of retroareolar tissue08 Withdrawn09 Reliable assessment of operative performance10 Video assessment as a method of assessing surgical competence: the difference in video-rating skills after 4 years of residency11 Burnout among academic surgeons13 Increased health services use by severely obese patients undergoing emergency surgery: a retrospective cohort study14 Novel models for advanced laparoscopic suturing: taking it to the next level16 Pectoral nerve block in breast and axillary surgery17 Predictors for positive resection margins in gastric adenocarcinoma: a population-based analysis18 Predictors of malignancy in thyroid nodules19 Safety and efficacy of POEM for treatment of achalasia: a systematic review of the literature20 Informed consent for surgery21 Meconium ileus: 20 years of experience22 Paraesophageal hernia repair in the elderly: outcomes in a 10-year retrospective study23 The changing face of breast cancer: younger age and aggressive disease in Filipino Canadians24 A systematic review of intraoperative blood loss estimation methods for major noncardiac surgery: a 50-year perspective25 The AVATAR trial: applying vacuum to accomplish reduced wound infections in laparoscopic pediatric surgery27 Indications for use of damage control surgery in civilian trauma patients: a content analysis and expert appropriateness rating study28 Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients: a content analysis and expert appropriateness rating study29 The impact of health care contact and invasive procedures on Staphylococcus aureus bacteremia: a 5-year retrospective cohort study30 Acute care surgery — positive impact on gallstone pancreatitis31 Safety and efficacy of a step-up approach to management of severe, refractory Clostridium difficile infection32 Clinical and operative outcome of patients with acute cholecystitis who are treated initially with image-guided cholecystostomy34 Assessment of preoperative carbohydrate loading and blood glucose concentration in patients with diabetes35 Impact of pre-emptive lidocaine infiltration at trocar sites (PLITS) and intraoperative ketorolac administration on postoperative pain and narcotics consumption after endocholecystectomy: a randomized-controlled trial36 Expert intraoperative judgment and decision-making: defining the cognitive competencies for safe laparoscopic cholecystectomy37 Teaching clinical anatomy to postgraduate surgical trainees38 Investigating the role of TNFR1 in gastric adenocarcinoma peritoneal metastasis39 Selective outcome reporting and publication biases in surgical randomized controlled trials40 Definitive percutaneous management of symptomatic cholelithiasis41 Peer-based coaching: an innovative method to teach faculty an advanced laparoscopic technique42 Improving teaching and learning in the operating room: Does the surgical procedure feedback rubric support learning?43 Withdrawn44 Mislabelling study designs as case–control in surgical literature45 Measured resting energy expenditure in patients with open abdomens: preliminary data of a prospective pilot study46 Open abdomen management and primary abdominal closure in a surgical abdominal sepsis cohort: a retrospective review47 The effect of early mobilization protocols on postoperative outcomes following abdominal and thoracic surgery: a systematic review49 Program directors and trainees attitudes toward the introduction of multi-source feedback as part of surgical residents’ formative assessment process at the University of Calgary: a qualitative study50 Outcomes associated with alternate blunt cerebrovascular injury detection strategies in major trauma patients: a systematic review and meta-analysis51 Assessing the effect of preoperative nutrition on the surgical recovery of elderly patients53 Why is the percentage of medical students selecting a general surgery career different between Canadian medical schools?54 Colorectal cancer patient perspectives of preoperative repeat endoscopy: a qualitative study55 Staphylococcus aureus bacteremia in a pediatric population: a retrospective study in a tertiary-care referral centre56 The impact of postoperative complications on the recovery of elderly surgical patients57 Withdrawn58 The economics of recovery after pancreatic surgery: detailed cost minimization analysis of a postoperative clinical pathway for patients undergoing pancreaticoduodenectomy59 2015 CJS Editor’s Choice Award Recipient: Achalasia-specific quality of life after pneumatic dilation and laparoscopic Heller myotomy with partial fundoplication: a randomized clinical trial60 NSAID use is associated with an increased risk of anastomotic leak after colorectal surgery: results of a frequentist and Bayesian meta-analysis61 Miracles for babies with abnormal lungs: the story of miR-10a and lung development62 Investigating hospital readmissions and unplanned ED visits following general surgical procedures at a tertiary care centre63 Remote FLS testing: ready for prime time64 Contrast blush (CB) significance on computed tomography (CT) and correlation with noninterventional management (NIM) failure for blunt splenic injury (BSI) in children65 Bridging the gap on the surgical ward: enhancing resident–nurse communication through a CUSP pilot project66 A prospective interim analysis of microbiological gene expression profile of Staphyloccocus aureus bacteremia and its clinical implications67 Outcomes of selective nonoperative management of civilian abdominal gunshot wounds: a systematic review and meta-analysis68 Does rater training improve the reliability of surgical skill assessments? A randomized control trial69 Parallel or divergent? The evolution of emergency general surgery service delivery at 3 Canadian teaching hospitals70 Surgeon satisfaction in the era of dedicated emergency general surgery services: a multicentre study74 Withdrawn76 Timing of cholecystectomy after gallstone pancreatitis: Are we meeting the standards?77 Management of traumatic occult hemothorax, a survey of trauma providers in Canada78 Withdrawn01 Extent of lymph node involvement after esophagectomy with extended lymphadenectomy for esophageal adenocarcinoma predicts recurrence: a large North American cohort study02 A randomized comparison of electronic versus handwritten daily notes in thoracic surgery03 Is tissue still the issue? Lobectomy for suspected lung nodules without preoperative or intraoperative confirmation of malignancy04 Incidence of pulmonary embolism and deep vein thrombosis following major lung resection: a prospective multicentre incidence study05 Venous thromboembolism (VTE) prophylaxis in thoracic surgery: a Canadian national delphi consensus survey06 Preoperative chemoradiation therapy v. chemotherapy in patients undergoing modified en bloc esophagectomy for locally advanced esohageal adenocarcinoma: Does radiation add value?07 Comparative outcomes following tracheal resection for benign versus malignant conditions08 Combined clinical staging for resectable lung cancer: clinicopathological correlations and the role of brain MRI10 A retrospective cohort evaluation of non–small cell lung cancer recurrence detection11 Health-related quality of life measure distinguishes between low and high T stages in esophageal cancer12 Transition from multiport to single-port anatomic lung resection is feasible13 Survival rates in patients with N3 esophageal adenocarcinoma treated with neoadjuvant chemotherapy and esophagectomy with en-bloc lymphadenectomy14 Impact of a dedicated outpatient clinic on the management of malignant pleural effusions16 Has the quality of reporting of randomized controlled trials in thoracic surgery improved?17 Clinical features distinguishing malignant from benign esophageal diagnoses in patients referred to an esophageal diagnostic assessment program18 Concordance with invasive mediastinal staging guidelines19 Current lung-protective ventilation strategies may not be protective during one-lung ventilation surgery20 National practice variation in pneumonectomy perioperative care — results from a survey of the Canadian Association of Thoracic Surgeons21 Outcomes after multimodal treatment of esophagogastric neuroendocrine carcinoma: Is there a role for resection?22 Clinical results of treatment for isolated axillary and plantar hyperhidrosis: a single centre experience23 The role of pneumonectomy after neoadjuvant chemotherapy for N2 non–small cell lung cancer24 Time delays in the management of non–small cell lung cancer: a comparison between high-volume designated and low-volume community hospitals25 Regionalization and outcomes of lung cancer surgery in Ontario, Canada26 Robotic pulmonary resection for lung cancer: the first Canadian series01 The effect of early postoperative nonsteroidal anti-inflammatory drugs on pancreatic fistula following pancreaticoduodenectomy02 Laparoscopic ultrasound still has a role in the staging of pancreatic cancer: a systematic review of the literature03 Impact of portal vein embolization on morbidity and mortality of major liver resection in patients with colorectal metastases: experience of a small single tertiary care centre04 A decision model and cost analysis of intraoperative cell salvage during hepatic resection05 The impact of portal pedicle clamping on survival from colorectal liver metastases in the contemporary era of liver resection: a matched cohort study06 Clinical and pathological features of intraductal papillary neoplasms of the biliary tract and gallbladder07 International practice patterns among ALPPS surgeons: Do we need a consensus?08 Omental flaps to protect pancreaticojejunostomy in pancreatoduodenectomy11 Preoperative diagnostic angiogram and endovascular aortic stent placement for appleby resection candidates: a novel surgical technique in the management of locally advanced pancreatic cancer12 Recurrence following initial hepatectomy for colorectal liver metastases: a multi-institutional analysis of patterns, prognostic factors and impact on survival13 The influence of the multidisciplinary cancer conference era on the management of colorectal liver metastases14 Monosegment ALPPS hepatectomy: extending resectability by rapid hypertrophy15 How does simultaneous resection of colorectal liver metastases impact chemotherapy administration?16 Preoperative liver volumetry for surgical planning: a systematic review and evaluation of current modalities17 Surgical planning of hepatic metastasectomy using radiologist performed intraoperative ultrasound21 Surgical resection and perioperative chemotherapy for colorectal cancer liver metastases: a population-based study22 Management and outcome of colorectal cancer (CRC) liver metastases in the elderly: a population-based study23 Outcomes following repeat hepatic resection for recurrent metastatic colorectal cancer: a population-based study24 A clinical pathway after pancreaticoduodenectomy standardizes postoperative care and may decrease postoperative complications25 Significance of regional lymph node involvement in patients undergoing liver resection and lymphadenectomy for colorectal cancer metastases26 NSAID use and risk of postoperative pancreatic fistulas following pancreaticoduodenectomy: a retrospective cohort study27 Minimally invasive HPB surgery in Canada: What are we doing and do we want to do more?28 2015 CJS Editor’s Choice Award Recipient: Predictors of actual survival in resected pancreatic adenocarcinoma: a population-level analysis29 Predictors of receipt of adjuvant therapy following pancreatic adenocarcinoma resection: a population-based analysis30 Effect of surgical wait time on oncological outcomes in periampullary cancer31 Does surgical assist expertise affect resectability in periampullary malignancies?32 The impact of tranexamic acid on fibrinolytic activity during major liver resection33 Colorectal cancer with synchronous hepatic metastases: a national survey of opinions on treatment sequencing and multidisciplinary cooperation34 Outcomes associated with a matched series of patients undergoing sequential resections of colorectal cancer and hepatic metastases compared with synchronous surgical therapy of the primary and hepatic metastases35 The impact of anesthetic inhalational agent on short-term outcomes after liver resection38 The impact of perioperative blood transfusions on posthepatectomy short-term outcomes: an analysis from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)39 Associations between pancreatic cancer quality indicators and outcomes in Nova Scotia40 Developing a national quality agenda in hepato-pancreato-biliary surgery: key priority areas for study02 Withdrawn03 Histological features and clinical implications of polypropylene degradation04 A rare case of primary hernia of the perineum05 Migration of polypropylene mesh in the development of late complications06 Laparoscopic hernia repair — Has this procedure run its course?07 Mesh materials used for hernia repair: Why do they shrink?08 The role of pure tissue repairs in a tailored concept for inguinal hernia repair09 Recurrent inguinal hernias a persistent problem in hernia surgery: analysis of 14 640 recurrent cases in the German hernia database, Herniamed10 Open circular intra-abdominal ventral herniorrhaphy: a new technique in ventral hernia repair01 Misrepresentation or 'spin' is common in robotic colorectal surgical studies02 Postoperative pelvic sepsis rates following complete pathologic response to neoadjuvant therapy in rectal cancer03 Understanding the complexities of shared decision-making in cancer: a qualitative study of the perspectives of patients undergoing colorectal surgery04 Impact of hospital volume on quality indices for rectal cancer surgery in British Columbia, Canada07 The effect of laparoscopy on inpatient cost after elective colectomy for colon cancer08 Predictors of variation in neighbourhood access to laparoscopic colectomy for colon cancer09 Predictors of 30-day readmission after elective colectomy for colon cancer10 Neutrophil-to-lymphocyte ratio predicts major perioperative complications in patients with colorectal cancer12 Sessile serrated adenoma (SSA) detection-predictive factors13 Diverticular abscess managed with long-term definitive nonoperative intent is safe14 Long-term outcomes of conservative management following successful nonoperative treatment of acute diverticulitis with abscess: a systematic review15 Incidence of ischemic colitis after abdominal aortic aneurysm repair: results from the national surgical quality improvement program database16 Sigmoid colectomy for acute diverticulitis in immunosuppressed v. immunocompetent patients: outcomes from the ACS-NSQIP database17 A cross-sectional survey of health and quality of life of patients awaiting colorectal surgery in Canada19 Self-expanding metal stents versus emergent surgery in acute malignant large bowel obstruction20 Combined laparoscopic and TAMIS LAR in a morbidly obese patient after open right hepatectomy21 Safety and feasibility of laparoscopic rectal cancer resection in morbidly obese patients22 Factors associated with morbidity following sacral neurostimulation for fecal incontinence: beware of the high risk groups23 Hyperglycemia increases surgical site infections following colorectal resections for malignancy in a standardized patient cohort24 Implementing an enhanced recovery program after colorectal surgery in elderly patients: Is it feasible?25 From laparoscopic-assisted to total laparoscopic right colectomy with intracorporeal anastomosis: Is the shift in technique justified?26 Surgical site infection rates following implementation of a 'colorectal closure bundle' in elective colorectal surgeries27 Quality of life and anorectal function of rectal cancer patients in long-term recovery28 Combined laparoscopic/transanal endoscopic microsurgery approach to radical resection for rectal tumours29 Transanal endoscopic microsurgery resection of rectal neuroendocrine tumours: a single centre Canadian experience30 Abdominoperineal reconstruction with a myocutaneous flap32 Comparison of robotic and laparoscopic colorectal surgery with respect to 30-day perioperative morbidity33 Definitive management of fistula-in-ano using draining setons35 Oncologic outcomes following complete pathologic response to neoadjuvant therapy in rectal cancer36 Laparoscopic total mesorectal excision in obese patients with rectal cancer: What is the oncological impact?38 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer39 Fistulae related to colonic diverticular disease: a single institution experience41 Laparoscopic colectomy for malignancy provides similar pathologic outcomes and improved survival outcomes compared with open approaches42 MRI utilization and completeness of reporting in rectal cancer: a population-based study43 Supporting quality assurance initiatives for rectal cancer: Is the CAP protocol enough?44 Accuracy and predictive ability of preoperative MRI for rectal adenocarcinoma: room for improvement47 A population-based study of colorectal cancer in patients ≤ 40: Does the extent of resection affect outcomes?48 Transanal minimally invasive surgery (TAMIS) for rectal neoplasms01 The impact of blood transfusion on perioperative outcomes following resection of gastric cancer: an analysis of the ACS-NSQIP02 Association of wait time to surgical management with overall survival in Ontarians with melanoma04 General surgeons’ attitudes toward breast reconstruction in the province of Quebec06 Neoadjuvant chemotherapy for breast cancer: Is practice changing? A population-based review of current surgical trends07 Robotic versus laparoscopic versus open gastrectomy for gastric adenocarcinoma15 Influence of preoperative MRI on the surgical management of breast cancer patients17 Adverse events related to lymph node dissection for cutaneous melanoma: a systematic review and meta-analysis19 Regional variations in survival, case volume and intraoperative margin assessment in resected gastric cancer20 Comparison of clinical and economic outcomes between robotic, laparoscopic and open rectal cancer surgery: early experience at a tertiary care centre21 Outcomes and clinicopathologic features of patients with Angiosarcoma of the breast23 Postmastectomy radiation: Should subtype factor in to the decision?24 Omission of axillary staging in elderly patients with early stage breast cancer impacts regional control but not survival: a systematic review and meta-analysis25 Objective pathological assessment of CRCLM by MALDI26 Identification of predictive tumour markers in breast cancer tissue — a pilot study research plan27 Reframing women’s risk: counselling on contralateral prophylactic mastectomy in non–high risk women with early breast cancer28 Withdrawn30 Comparison of different methods of immediate breast reconstructions for breast cancer patients: Is 'single stage' really better?32 Is lymph node ratio a more accurate prognostic factor in stage III colon cancer than standard nodal staging?33 Costs associated with reoperation in the setting of attempted breast-conserving surgery: a decision analysis34 Polo-like kinase 4 (Plk4) activates Cdc42, stimulates cell invasion and enhances cancer progression in vivo35 Negative predictive value of preoperative abdominal CT in determining gastric cancer resectability on a population level36 2015 CJS Editor’s Choice Award Recipient: (18)F-fluoroazomycin arabinoside positron emission tomography (FAZA-PET) imaging predicts response to chemoradiation and evofosfamide (TH-302) in a preclinical xenograft model of rectal cancer37 Impact of a regional guideline on the surgical treatment of the axilla in patients with breast cancer: a population-based study39 Recent trends in port-site metastasis following laparoscopic resection of gallbladder cancer: a systematic review40 Real-time electromagnetic navigation for breast tumour resection: pilot study on palpable tumours41 Neoadjuvant imatinib for primary gastrointestinal stromal tumour (GIST): mutational status and timing of resection42 Adherence to osteoporosis screening guidelines in seniors with breast cancer treated with anti-estrogen therapy: a population-based study43 Automated robot interventions for enhanced clinical outcomes in breast biopsy44 Preoperative pregabalin or gabapentin for postoperative acute and chronic pain among patients undergoing breast cancer surgery: a systematic review and meta-analysis of randomized controlled trials46 Uptake and impact of synoptic reporting on breast cancer operative reports in a community care setting47 Withdrawn

Author

J. Eng, A.S. Rai, M. Anvari, D. Henault, D.A. Bischof, G. Gauvin, D. Berger-Richardson, M. Tsao, A. Haller, D.J. Kagedan, K. Kazazian, C.R. Baliski, A.J. MacNeill, Y. Zhang, A.M. Covelli, A.E. Schellenberg, B. Alabdulkarim, S. Liang, A.S. Scheer, M.K. Gervais, K.M. Ramji, T.D. Hamilton, H.H. Alabbas, A. Parsyan, E. Kakiashvili, P. Graham, E. Karam, A.B. Crawford, M. Elmi, U. Hameed, R. Daigle, C.A. MacPherson, D. Mihalicz, S.A. Chadi, A.S. Jastaniah, C. Peeples, F. Letarte, O. Daodu, A.E. Feinberg, A-M. Dufresne, C. Jonker, C.J. Brown, X. Wang, A. Ghuman, C. Antczak, A. Brind’Amour, C. Morin, I.L. Browne, A. Karimuddin, A. Al-Khamis, M. Abou Khalil, A. Kugler, R. Garfinkle, J.M. Josse, A.G. Doumouras, R.J. McColl, D.H. Hirpara, S.V. Patel, S. Yeretsian, R. Lorenz, A. Koch, R. Guidoin, J.A. Morrison, V. Iakovlev, R. Krouchev, V.V. Iakovlev, A.C. Wei, S. Hurton, J. Hallet, R. Habashi, C. Howard, T.W. Clements, P.J. Karanicolas, M. Meschino, E. Lau, R. Jrearz, M.S. Rashid, S. Nanji, S. Tung, L. O’Malley, K.M. Eltawil, K. Pineda-Solis, M.E. Tun-Abraham, N. Trabulsi, V.K. Kapoor, S. Buac, S. Bennett, M.E. Tsang, M. Lemke, P. Cyr, J. Levy, R. Behman, W.C. Hanna, A. Bendzsak, P. Dibajnia, J. Spicer, L. Donahoe, S. Gowing, B. Kidane, D. Cornejo-Palma, A.M. Bendzsak, C.K. Wen, N. Dharampal, R. El-Safty, J. Cools-Lartigue, D. French, I.C. Yeung, J. Vernon, J. Agzarian, S. Kaaki, S. Najmeh, R. Rae, A. Banmann, S. Khorasani, B. Anderson, R.L. Maniar, A.N. Al-Rawahi, D.L. Pepe, S.Y.S. Yeh, A. Bougie, A. Okrainec, R.P. Musselman, R. Visser, L. Sandhu, C.C. Chrystoja, M. Tahiri, R.V. Anantha, W.J. Choi, J. Hollett, T. Sikder, M. Lipson, A. Reso, T. Castelino, M.S. Bleszynski, M.E. Hassan, S. Knowles, A. Toprak, V.N. Palter, S. Sun, P. Glen, M. Alzahrani, M. Ernjakovic, A. Madani, M. Qiabi, M. Laffin, I. Molavi, P. Murphy, D.J. Roberts, A. Tran, K. Briggs, N. Ahmadi, D. Kinnear, M. Hanson, O.M. Crespin, B. Catton, Y. Watanabe, S. Küpper, A. Nassar, N. Gawad, E. Bilgic, S. Lyew, D.N. Ginther, M. Mak, F. Saleh, K. Karol, M. Auspitz, S. Elkassem, N.J. Switzer, C. Fulton, E. Lester, P. Leung, D. Terterov, C. Smith, D. Pace, L. Twells, R. Murphy, K. Lester, D. Gregory, D. Boone, R. Padwal, F. Ye, D. Birch, S. Karmali, A.M. Sharma, S. Klarenbach, J.-E. Tarride, D. Hong, S. Gmora, M. Gostimir, F. Haggar, J.-D. Yelle, J. Mamazza, A. Neville, C.E. Sheppard, D.W. Birch, C.J. de Gara, S. Merani, null Skubleny, J.-S. Pelletier, R.S. Gill, R. Kanji, X. Shi, C. de Gara, S.E. Jelinski, N. McGuire, R.S. Padwal, S. Crawford, R. Lewancuzk, M.C. Cleghorn, A. Azin, S. Sockalingam, F.A. Quereshy, T.D. Jackson, R. Talboys, S. Garg, J. Porter, R. Saskin, J. Rangrej, D.R. Urbach, P. Hayes, A. Ayoub, M. Musgrave, H. Faragalla, R. George, K.M. McKendy, A. Munshi, G.M. Fried, L.S. Feldman, M.C. Vassiliou, G. Martel, I. Raiche, F.K. Balaa, S. Reid, K. Kahnamoui, M. McConnell, C.J. Karvellas, R.G. Khadaroo, S. Widder, G. Enani, N.L. Hong, D. Kagedan, J.C. Correa, A. El-Sedfy, M. Dixon, A. Mahar, C. Roswell, L. Helyer, J. Vasilevska-Ristovska, C. Law, D. Cortinovis, B. Zagorski, N. Coburn, F. Christian, G. Caspar-Bell, A. Parmar, L.W.C. Liu, E. Shlomovitz, D.M. Pitt, P. Prasil, J. Simpson, J. Heuser, D. Fergusson, K. Milbrandt, S. Lum Min, N. Wiseman, B.J. Hancock, M. Morris, R. Keijzer, N. Bobrovitz, D.A. Zygun, C.G. Ball, A.W. Kirkpatrick, P.D. Faris, K. Brohi, S. D’Amours, T.C. Fabian, K. Inaba, A.K. Leppäniemi, E.E. Moore, P.H. Navsaria, A.J. Nicol, N. Parry, H.T. Stelfox, D. Pepe, R. Anantha, F. Priestap, J. McCormick, T. Mele, J. Koichopolos, D. Paskar, K. Leslie, K. Lung, G. McCreery, M. Ott, C. Vinden, R. Hernandez-Alejandro, D. Gray, P. Quigley, R. Brisebois, P. Senior, H. Wang, A. Paré, A. Dudemaine, S.K. Mayer, R. Aggarwal, J.S. Barkun, T. Wood, M.T. Hincke, C. Seabrook, C. Ramnanan, F. Balaa, R. Kayano, B. Giannias, F. Bourdeau, L. Ferri, R. Wu, H. Moloo, R. Breau, W. Harris, A. Kavanagh, A. Jokhio, K. Beyfuss, A. Ryzynski, S.A. Ashamalla, U. Luhanga, S. Jones, A. Winthrop, L. McEwen, V. DeMelo, H. Yan, S. Iqbal, N. Fong, J. Grushka, D. Deckelbaum, L. St. Laurent, E. Eckert, T. Razek, K. Khwaja, T. Chan, A.K. Buczkowski, J.F. Fiore, P. Niculiseanu, B. Augustin, K. Dalrymple, A. Harvey, E. Jost, G. Maimon, D. Teasdale, N. Sourial, S. Demyttenaere, S. Fraser, S. Bergman, T. Scott, A. Bateman, J. Delport, S.M.M. Haeryfar, J.K. McCormick, J. Guralnick, S.A. Fraser, A. Ramjaun, A. Tremblay-St. Germain, K.S. Devitt, S.P. Cleary, G.E. Darling, N.E. Diamant, P.P. Kortan, G.A. Tomlinson, W. Deitel, A. Laporte, J. Takata, F. Angarita, G. Tomlinson, R.S. McLeod, A. Govindarajan, C. Fraser, D. Mulhall, F. Zhu, B. Iwasiow, T. Mahood, T. Jackson, M. Aupitz, F. Quereshy, A. Tse, A. Okrainee, R. McLeod, M. Vassiliou, M.C. Jimenez, O. Henao, P. Kaneva, M. Ritter, F.C. Malo, N. McFadden, A. Ouimet, J.M. Aubin, A. Berg, D. Carver, K. Lacelle, M. McGrath, J. Rekman, B. Skinner, K.K. McCormick, F.A. Al-Hinai, C.J. Doig, J.B. Kortbeek, A. Vergis, L. Gillman, K. Hardy, J. Park, J.M. Sutherland, S.M. Hameed, N. Switzer, J. Shum, J. Lampron, H. Jiang, M.L. Leimanis, P. Mossallanejad, L.E. Ferri, C. Anstee, S. Gilbert, D. Maziak, F. Shamji, S. Sundarean, J. Villeneuve, A. Seely, S. Srinathan, L. Tan, G. Buduhan, L. Schneider, C. Finley, C. Schieman, L.A. Linkins, M. Crowther, M. De Perrot, T. Waddell, Y. Shargall, B. Stiles, M. Sudarshan, A. Correa, N. Altorki, W. Hofstetter, R. Rice, J. Shewale, B. Sepesi, M. Antonoff, G. Walsh, S. Swisher, T. Estrera, H. Safi, K. Khalil, N. Andruszkiewicz, C.J. Finley, C. Fahim, F. Farrokhyar, H. Yakubu, R. Addas, D.E. Maziak, P.J. Villeneuve, S. Sundaresan, J. Sulman, W. Xu, Q.Q. Kong, R. Wong, J.J. Knox, C. Thompson, L. Baker, A. Behzadi, J.P. Edwards, W. Chung, M.S. Brar, J. Seto, S.C. Grondin, S. Demay, E. Reynolds, J. Morton, T.K. Waddell, K. Yasufuku, S. Keshavjee, M. Cypel, A. Pierre, M. Hamilton, D. Fortin, E. Frechette, R. Inculet, N. Badner, R. Malthaner, R.A. Malthaner, G. Darling, D. Jones, C. Mueller, M. Leimanis, K. Wanzel, B. Lychacz, C. Compeau, D. Rice, A. Vaporciyan, R. Mehran, J. Roth, J. Lee, N. Baxter, P. Austin, P. Patel, S.S. Hanna, N.G. Coburn, C.H.L. Law, T. Vanounou, V. Falk, P. Collingwood, M. Hogan, A. Mathieson, G. Eeson, Y. Lin, J. Tarshis, S. Hanna, P. Karanicolas, E. Cheng, E.C. Marginean, M. Paquin-Gobeil, J. Wasserman, J. Weaver, R. Mimeault, E. Schadde, A.A. Schnitzbauer, K. Vogt, A. Behari, N. Gupta, R.K. Singh, J.S. Pelletier, C. Abraham, A. Sa Cunha, R. Adam, D. Goére, P. Bachelier, D. Azoulay, A. Ayav, E. Grégoire, F. Navarro, P. Pessaux, H.A. Cano, D. Quan, E. De-Santibañez, M. Tun-Abraham, D. Mirsattari, H.A. Cano-Gonzalez, A. Menard, S. Wong, D. Jalink, W.J. Mackillop, X. Wei, C.M. Booth, A.T. St-Germain, S. Gallinger, D. Dath, Y. Essaji, H. Kaka, M.J. Marcaccio, V. Tandan, T. Tang, F. Yuan, L. Ruo, P. Serrano, R. Raju, M.E. Dixon, E. Shin, Q. Li, N. Liu, C. Earle, N. Mittmann, K. Bertens, J. Hawel, B. Buck, M. Hamel-Smith, S. McCluskey, W.D. Buie, E. Dixon, A.R. MacLean, A. Gomes, S. Jayaraman, J. Khan, Y. LeManach, A.L. Mahar, J. Callum, G. Porter, A. Levy, M. Molinari, K. Devitt, S.A. Guelcher, R. Bendavid, J. Labrecque, G. Brochu, L. Miao, L. Wang, F. Köckerling, J.A. Van Koughnett, B. Howe, S.D. Wexner, I. Datta, C. MacPherson, H. Huang, B. O’Connor, S. Schmocker, E. Kennedy, J.A. Heine, C.E. McGahan, E. Cai, M.J. Raval, P.T. Phang, A.A. Karimuddin, J. Heine, M. Brar, R.J. Hilsden, V. Pelsser, P.H. Gordon, N. Morin, C.A. Vasilevsky, J. Faria, G. Ghitulescu, L. Feldman, M. Boutros, C. Vasilevsky, M. Demian, J. Abou Khalil, P. Gordon, D. Obrand, C.-A. Vasilevsky, C. Brown, M. Raval, P. Phang, G. Liu, R. Crump, J. Sutherland, S. Drolet, T. MacLean, A. Bouchard, P. Bouchard, C. Thibault, R.C. Grégoire, J. Gagné, A.J. Cracco, F.G. Rodrigues, M. Zutshi, B. Gurland, G. da Silva, N.M. Saur, D. Bekele, H. Amer, E.G. Weiss, Y. Bendavid, M. Poirier, F. Heyen, J.F. Latulippe, M. Henri, P.K. Stotland, L.V. Klein, M.A. Aarts, S. Ashamalla, C. Richard, R. Loungnarath, E. Debroux, J. Pelletier, S. Nicholaidis, J-P. Brutus, A. Elnahas, S. Bashir, J. O’Keefe, R. Gregoire, J.P. Gagne, R. Akiba, C. Reategui, G. DaSilva, S. Wexner, E. Weiss, M. Berho, M. Taylor, T. McMullen, H. Singh, F.A. Angarita, C. Nessim, C. van Walraven, M. Guez, M. Beniey, R. Younan, J. Bou-Merhi, A.M. Danino, E. Patocskai, T. Foster, M. McCall, A. Bouchard-Fortier, W. Temple, M.L. Quan, E. Brauner, O. Ben Yshai, R. Almog, A. Beny, Y. Kluger, A.M. Rodriguez-Rivera, S. Krotneva, S. Chang, L. Patakfalvi, T. Landry, A. Meguerditchian, H. Adamson, H. Lim, H. Kennecke, W. Cheung, C. Speers, A.F. McFadden, Y.J. McConnell, A. MacNeill, C. O’Brien, D. Urbach, S.M. Burtenshaw, J. Maxwell, B. Dickson, M. Blackstein, J.M. Escallon, R. Gladdy, F. Zih, E. Maki, C.A. Koch, D.R. McCready, J.S. Simpson, A.C. Tricco, H. Patterson, A. Lazaris, P. Chaurand, P. Metrakos, T.A. Harkness, G. Groot, G.F. Davies, T. Arnason, N.N. Baxter, F.C. Wright, A. Arnaout, M. Cleghorn, W. Jin, H. Yang, R. Pataky, R. Xu, O. Brashavitskaya, H. Wu, C. Go, C.J. Swallow, F. Frankul, C. McGregor, C. Rowsell, C.H. Law, T. Mckee, Y. Wang, E. Lima-Fernandes, B. Wouters, M. Smith, D. Jaffrey, S.D. Cornacchi, N. Hodgson, M. Simunovic, L. Thabane, M.A. O’Brien, B. Strang, S.D. Mukherjee, D. Bhatia, P.J. Lovrics, T. Chesney, M. Englesakis, T. Ungi, C.T. Yeo, G. Fichtinger, R. Walker, J. Rudan, C.J. Engel, J. Swett-Cosentino, A.J. Cannell, S. Burtenshaw, M.E. Blackstein, S. Dumitra, S.-L. Chang, R. Kramer, N. Mayo, A.N. Meguerditchian, N. Duchesne, K.G. Chan, T. Chapman, H. Clarke, J. Dhaliwal, S. Choi, J.W. Busse, P.J. Devereaux, and C. Baliski

Subjects
Surgery
Published
2015

11. Erratum: First axion results from the XENON100 experiment [Phys. Rev. D 90 , 062009 (2014)]

Author

H. Landsman, Daniel Lellouch, F. Piastra, S. Schindler, B. Miguez, L. Scotto Lavina, M. Selvi, M. Auger, Hardy Simgen, A. D. Ferella, Hulin Wang, C. Levy, Kaixuan Ni, D. Mayani Paras, M. Messina, K. Arisaka, G. Kessler, P. Shagin, N. Priel, A. Kish, J. Naganoma, F. Arneodo, H. Contreras, J.A.M. Lopes, C. Balan, Marc Schumann, Y. Meng, Ethan Brown, S. Reichard, W. Fulgione, M. P. Decowski, U. Oberlack, Manfred Lindner, O. Vitells, C. Geis, A. Rizzo, C. Grignon, A. Tiseni, A. Molinario, Giacomo Bruno, S. Macmullin, Florian Kaether, T. Marrodán Undagoitia, S. Bruenner, Gabriella Sartorelli, R. F. Lang, C. Weinheimer, A. P. Colijn, D. Thers, M. Weber, Guillaume Plante, Boris Bauermeister, W. Hampel, M. Garbini, April S. Brown, R. Itay, Jochen Schreiner, F. V. Massoli, M. Le Calloch, C. Reuter, S. E. A. Orrigo, Elena Aprile, João Cardoso, F. Gao, S. Rosendahl, J.M.F. dos Santos, F. Agostini, Sebastian Lindemann, E. Pantic, R. Budnik, Luke Goetzke, S. Fattori, G. C. Trinchero, A. J. Melgarejo Fernandez, M. Murra, Jean-Pierre Cussonneau, M. Alfonsi, K. Lung, Laura Baudis, J. Pienaar, P. Beltrame, Ehud Duchovni, A. Behrens, A. Lyashenko, A. Teymourian, P. Barrow, K. Bokeloh, E. K. U. Gross, R. Persiani, Julien Masbou, Aprile, E., Agostini, F., Alfonsi, M., Arisaka, K., Arneodo, F., Auger, M., Balan, C., Barrow, P., Baudis, L., Bauermeister, B., Behrens, A., Beltrame, P., Bokeloh, K., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Cardoso, J. m. r., Colijn, A. p., Contreras, H., Cussonneau, J. p., Decowski, M. p., Duchovni, E., Fattori, S., Ferella, A. d., Fulgione, W., Gao, F., Garbini, M., Geis, C., Goetzke, L. w., Grignon, C., Gross, E., Hampel, W., Itay, R., Kaether, F., Kessler, G., Kish, A., Landsman, H., Lang, R. f., Le Calloch, M., Lellouch, D., Levy, C., Lindemann, S., Lindner, M., Lopes, J. a. m., Lung, K., Lyashenko, A., Macmullin, S., Marrodán Undagoitia, T., Masbou, J., Massoli, F. v., Mayani Paras, D., Melgarejo Fernandez, A. j., Meng, Y., Messina, M., Miguez, B., Molinario, A., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Orrigo, S. e. a., Pantic, E., Persiani, R., Piastra, F., Pienaar, J., Plante, G., Priel, N., Reichard, S., Reuter, C., Rizzo, A., Rosendahl, S., dos Santos, J. m. f., Sartorelli, G., Schindler, S., Schreiner, J., Schumann, M., Scotto Lavina, L., Selvi, M., Shagin, P., Simgen, H., Teymourian, A., Thers, D., Tiseni, A., Trinchero, G., Vitells, O., Wang, H., Weber, M., and Weinheimer, C.

Subjects
Physics, Particle physics, XENON DARK MATTER AXION, 010308 nuclear & particles physics, 0103 physical sciences, Limit (mathematics), 010306 general physics, Coupling (probability), 01 natural sciences, Axion
Abstract

n our paper, we presented searches for solar axions and galactic axionlike particles (ALPs) in the data collected by the XENON100 experiment (with an exposure of 224.6 days). We recently found a bug in the code to calculate the exclusion limit for galactic ALPs. This resulted in an underestimation of the ALP expected rate, which in turn led to an overly conservative limit, compared to what it should really be. We corrected the code, and the result of the XENON100 90% C.L. exclusion limit on galactic ALPs (shown in Fig. 1) was reevaluated. The corrected limit is stronger than the one previously published by approximately a factor of 5 across all masses and sets the best published limit on the axion-electron coupling, $g_{Ae}$, in the (1–40) keV/$c^2$ mass range.

Published
2017

12. Analysis of the XENON100 dark matter search data

Author

S. E. A. Orrigo, Marc Schumann, P. Shagin, J. A. M. Lopes, A. Kish, Luke Goetzke, Jean-Pierre Cussonneau, K. E. Lim, Elena Aprile, E. Nativ, W. Hampel, M. Selvi, Ehud Duchovni, K. Bokeloh, E. K. U. Gross, João Cardoso, Hui Wang, Uwe Oberlack, Jochen Schreiner, M. Weber, F. Gao, A. Behrens, T. Marrodán Undagoitia, F. V. Massoli, Qing Lin, M. Le Calloch, J.M.F. dos Santos, O. Vitells, Ch. Weinheimer, A. Rizzo, P. Beltrame, W. Fulgione, N. Priel, C. Grignon, A. J. Melgarejo Fernandez, A. Teymourian, M. Garbini, K. Arisaka, S. Rosendahl, Sebastian Lindemann, M. Alfonsi, F. Arneodo, W. T. Chen, Ran Budnik, Kaixuan Ni, R. Persiani, Karl Giboni, David B. Cline, G. Sartorelli, Laura Baudis, C. Balan, Giacomo Bruno, Hardy Simgen, A. D. Ferella, H. Contreras, E. Pantic, K. Lung, Ethan Brown, M. P. Decowski, Manfred Lindner, Y. Mei, P. R. Scovell, Guillaume Plante, Y. Meng, A. Molinario, S. Fattori, C. Levy, B. Choi, D. Thers, R. F. Lang, J. Lamblin, H. Landsman, L. Scotto Lavina, The XENON100 Collaboration, Astroparticle Physics (IHEF, IoP, FNWI), Aprile, E., Alfonsi, M., Arisaka, K., Arneodo, F., Balan, C., Baudis, L., Behrens, A., Beltrame, P., Bokeloh, K., Brown, E., Bruno, G., Budnik, R., Cardoso, J.M.R., Chen, W.-T., Choi, B., Cline, D.B., Contreras, H., Cussonneau, J.P., Decowski, M.P., Duchovni, E., Fattori, S., Ferella, A.D., Fulgione, W., Gao, F., Garbini, M., Giboni, K.-L., Goetzke, L.W., Grignon, C., Gross, E., Hampel, W., Kish, A., Lamblin, J., Landsman, H., Lang, R.F., Le Calloch, M., Levy, C., Lim, K.E., Lin, Q., Lindemann, S., Lindner, M., Lopes, J.A.M., Lung, K., Marrodán Undagoitia, T., Massoli, F.V., Mei, Y., Melgarejo Fernandez, A.J., Meng, Y., Molinario, A., Nativ, E., Ni, K., Oberlack, U., Orrigo, S.E.A., Pantic, E., Persiani, R., Plante, G., Priel, N., Rizzo, A., Rosendahl, S., Dos Santos, J.M.F., Sartorelli, G., Schreiner, J., Schumann, M., Scotto Lavina, L., Scovell, P.R., Selvi, M., Shagin, P., Simgen, H., Teymourian, A., Thers, D., Vitells, O., Wang, H., Weber, M., and Weinheimer, C.

Subjects
Large Underground Xenon experiment, Physics - Instrumentation and Detectors, Xenon, WIMP, Physics::Instrumentation and Detectors, Direct detection, Dark matter, chemistry.chemical_element, FOS: Physical sciences, DarkSide, WIMP Argon Programme, Nuclear physics, Statistical analysis, Nuclear Experiment, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Time projection chamber, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), WIMPs, chemistry, Weakly interacting massive particles, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The XENON100 experiment, situated in the Laboratori Nazionali del Gran Sasso, aims at the direct detection of dark matter in the form of weakly interacting massive particles (WIMPs), based on their interactions with xenon nuclei in an ultra low background dual-phase time projection chamber. This paper describes the general methods developed for the analysis of the XENON100 data. These methods have been used in the 100.9 and 224.6 live days science runs from which results on spin-independent elastic, spin-dependent elastic and inelastic WIMP-nucleon cross-sections have already been reported., Comment: 18 pages, 17 figures, information for the 224.6 live days run included

Published
2014

13. Expected sensitivity to galactic/solar axions and bosonic super-WIMPs based on the axio-electric effect in liquid xenon dark matter detectors

Author

K. Arisaka, P. Beltrame, C. Ghag, P.F. Smith, R.D. Peccei, Justin Kaidi, A. Lyashenko, Ke Ye, and K. Lung

Subjects
Particle physics, Physics - Instrumentation and Detectors, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, chemistry.chemical_element, Astrophysics, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Xenon, WIMP, Sensitivity (control systems), Instrumentation and Methods for Astrophysics (astro-ph.IM), Axion, Physics, Detector, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), Photoelectric effect, High Energy Physics - Phenomenology, chemistry, Scintillation counter, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present systematic case studies to investigate the sensitivity of axion searches by liquid xenon detectors, using the axio-electric effect (analogue of the photoelectric effect) on xenon atoms. Liquid xenon is widely considered to be one of the best target media for detection of WIMPs (Weakly Interacting Massive Particles which may form the galactic dark matter) using nuclear recoils. Since these detectors also provide an extremely low radioactivity environment for electron recoils, very weakly-interacting low-mass particles (< 100 keV/c^2), such as the hypothetical axion, could be detected as well - in this case using the axio-electric effect. Future ton-scale liquid Xe detectors will be limited in sensitivity only by irreducible neutrino background (pp-chain solar neutrino and the double beta decay of 136Xe) in the mass range between 1 and 100 keV/c^2. Assuming one ton-year of exposure, galactic axions (as non-relativistic dark matter) could be detected if the axio-electric coupling g_Ae is greater than 10^-14 at 1 keV/c^2 (or $10^-13 at 100 keV/c^2). Below a few keV/c^2, and independent of the mass, a solar axion search would be sensitive to a coupling g_Ae ~ 10^-12. This limit will set a stringent upper bound on axion mass for the DFSV and KSVZ models for the mass ranges m_A < 0.1 eV/c^2 and < 10 eV/c^2, respectively. Vector-boson dark matter could also be detected for a coupling constant alpha'/alpha > 10^-33 (for mass 1 keV/c^2) or > 10^-27 (for mass 100 keV/c^2)., 17 pages, 10 figures

Published
2013

14. Status of Qupid, a novel photosensor for noble liquid detectors

Author

Y. Meng, A. Teymourian, Daniel Aharoni, K. Lung, Shinichi Muramatsu, E. Pantic, Motohiro Suyama, Ethan Brown, P. Beltrame, David B. Cline, T. Lim, Hui Wang, C. W. Lam, C. Ghag, K. Arisaka, P. R. Scovell, and Atsuhito Fukasawa

Subjects
Physics, Nuclear and High Energy Physics, Photomultiplier, Scintillation, Photon, business.industry, Dark matter, Detector, chemistry.chemical_element, Photodetector, medicine.disease_cause, Xenon, Optics, chemistry, medicine, Optoelectronics, business, Instrumentation, Ultraviolet
Abstract

The discovery potential of experiments searching for rare events, such as dark matter interaction, relies heavily upon achieving a very low background environment. The current generation of noble liquid dark matter detectors is limited by the radioactivity in the detector materials, mostly from the photomultiplier tubes. Quartz Photon Intensifying Detector (Q upid ) is a novel photosensor based upon hybrid APD technology and with intrinsic radioactivity at least an order of magnitude lower than the presently employed phototubes. The basic concept as well as the status and the prospect of the Q upid are reviewed. The performance of the Q upid as photosensor for the ultraviolet scintillation light of liquid xenon is presented.

Published
2012

15. Non-technical skills of surgeons and anaesthetists in simulated operating theatre crises

Author

K Lung, Steven Yule, Douglas S. Smink, John W. Scott, Aristithes G. Doumouras, M W Tsao, M Hamidi, and Christopher L. Tarola

Subjects
Inservice Training, Interprofessional Relations, Clinical Decision-Making, Blood Loss, Surgical, Theatre environment, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Clinical decision making, Blood loss, Rating scale, Medicine, Humans, 030212 general & internal medicine, Technical skills, Difficult airway, Simulation Training, Surgeons, business.industry, Communication, Awareness, medicine.disease, Airway Obstruction, Leadership, Anesthetists, Surgery, Observational study, Medical emergency, Clinical Competence, business
Abstract

Background Deficiencies in non-technical skills (NTS) have been increasingly implicated in avoidable operating theatre errors. Accordingly, this study sought to characterize the impact of surgeon and anaesthetist non-technical skills on time to crisis resolution in a simulated operating theatre. Methods Non-technical skills were assessed during 26 simulated crises (haemorrhage and airway emergency) performed by surgical teams. Teams consisted of surgeons, anaesthetists and nurses. Behaviour was assessed by four trained raters using the Non-Technical Skills for Surgeons (NOTSS) and Anaesthetists' Non-Technical Skills (ANTS) rating scales before and during the crisis phase of each scenario. The primary endpoint was time to crisis resolution; secondary endpoints included NTS scores before and during the crisis. A cross-classified linear mixed-effects model was used for the final analysis. Results Thirteen different surgical teams were assessed. Higher NTS ratings resulted in significantly faster crisis resolution. For anaesthetists, every 1-point increase in ANTS score was associated with a decrease of 53·50 (95 per cent c.i. 31·13 to 75·87) s in time to crisis resolution (P < 0·001). Similarly, for surgeons, every 1-point increase in NOTSS score was associated with a decrease of 64·81 (26·01 to 103·60) s in time to crisis resolution in the haemorrhage scenario (P = 0·001); however, this did not apply to the difficult airway scenario. Non-technical skills scores were lower during the crisis phase of the scenarios than those measured before the crisis for both surgeons and anaesthetists. Conclusion A higher level of NTS of surgeons and anaesthetists led to quicker crisis resolution in a simulated operating theatre environment.

Published
2016

16. XAX: A multi-ton, multi-target detection system for dark matter, double beta decay and pp solar neutrinos

Author

Haiyan Wang, C.W. Lam, P.F. Smith, K. Lung, A. Teymourian, Daniel Aharoni, S. Davies, Ethan Brown, W. Ooi, K. Arisaka, M. Price, and D. Cline

Subjects
Physics, Particle physics, Scintillation, 010308 nuclear & particles physics, Solar neutrino, Astrophysics (astro-ph), Dark matter, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Nuclear physics, MAJORANA, WIMP, Double beta decay, 0103 physical sciences, Scintillation counter, Neutrino, 010306 general physics
Abstract

A multi-target detection system XAX, comprising concentric 10 ton targets of 136Xe and 129/131Xe, together with a geometrically similar or larger target of liquid Ar, is described. Each is configured as a two-phase scintillation/ionization TPC detector, enhanced by a full 4pi array of ultra-low radioactivity Quartz Photon Intensifying Detectors (QUPIDs) replacing the conventional photomultipliers for detection of scintillation light. It is shown that background levels in XAX can be reduced to the level required for dark matter particle (WIMP) mass measurement at a 10^-10 pb WIMP-nucleon cross section, with single-event sensitivity below 10^-11 pb. The use of multiple target elements allows for confirmation of the A^2 dependence of a coherent cross section, and the different Xe isotopes provide information on the spin-dependence of the dark matter interaction. The event rates observed by Xe and Ar would modulate annually with opposite phases from each other for WIMP mass >~100 GeV/c^2. The large target mass of 136Xe and high degree of background reduction allow neutrinoless double beta decay to be observed with lifetimes of 10^27-10^28 years, corresponding to the Majorana neutrino mass range 0.01-0.1 eV, the most likely range from observed neutrino mass differences. The use of a 136Xe-depleted 129/131Xe target will also allow measurement of the pp solar neutrino spectrum to a precision of 1-2%., 16 pages with 17 figures

Published
2009

17. EKLF and KLF2 have compensatory roles in embryonic β-globin gene expression and primitive erythropoiesis

Author

Mohua Basu, Thanh Giang Sargent, Latasha C. Redmond, David C. Williams, Priyadarshi Basu, Tina K. Lung, Jack L. Haar, Joyce A. Lloyd, Jerry B. Lingrel, and Wafaa Lemsaddek

Subjects
Male, Erythrocytes, Red Cells, Immunology, Kruppel-Like Transcription Factors, KLF1, Biology, Biochemistry, Mice, Pregnancy, Gene expression, Animals, Erythropoiesis, RNA, Messenger, Globin, Yolk Sac, Mice, Knockout, Zinc finger, Genetics, Gene Expression Regulation, Developmental, Anemia, Cell Biology, Hematology, Embryo, Mammalian, Fetal Blood, Embryonic stem cell, Globins, Cell biology, Haematopoiesis, embryonic structures, KLF2, Female
Abstract

The Krüppel-like C2/H2 zinc finger transcription factors (KLFs) control development and differentiation. Erythroid Krüppel-like factor (EKLF or KLF1) regulates adult β-globin gene expression and is necessary for normal definitive erythropoiesis. KLF2 is required for normal embryonic Ey- and βh1-, but not adult βglobin, gene expression in mice. Both EKLF and KLF2 play roles in primitive erythroid cell development. To investigate potential interactions between these genes, EKLF/KLF2 double-mutant embryos were analyzed. EKLF−/−KLF2−/− mice appear anemic at embryonic day 10.5 (E10.5) and die before E11.5, whereas single-knockout EKLF−/− or KLF2−/− embryos are grossly normal at E10.5 and die later than EKLF−/−KLF2−/− embryos. At E10.5, Ey- and βh1-globin mRNA is greatly reduced in EKLF−/−KLF2−/−, compared with EKLF−/− or KLF2−/− embryos, consistent with the observed anemia. Light and electron microscopic analyses of E9.5 EKLF−/−KLF2−/− yolk sacs, and cytospins, indicate that erythroid and endothelial cells are morphologically more abnormal than in either single knockout. EKLF−/−KLF2−/− erythroid cells are markedly irregularly shaped, suggesting membrane abnormalities. EKLF and KLF2 may have coordinate roles in a common progenitor to erythroid and endothelial cells. The data indicate that EKLF and KLF2 have redundant functions in embryonic β-like globin gene expression, primitive erythropoiesis, and endothelial development.

Published
2007

18. DarkSide search for dark matter

Author

I. N. Machulin, R. Klemmer, Marco Pallavicini, N. Rossi, G. Forster, K. Fomenko, W. Sands, G. Di Pietro, H. Cao, D. D'Angelo, M. Komor, A. Razeto, N. N. Nurakhov, R. Saldanha, S. Parmeggiano, A. Nemtzow, E. Shields, F. Perfetto, Min-Xin Guan, M. Gromov, K. Randle, E. V. Unzhakov, S. Bussino, M. Orsini, M. Montuschi, E. Meroni, G. Korga, Austin P. Lund, Marc S. Seigar, A. Tonazzo, E. de Haas, G. Testera, L. Lukyanchenko, S. Gazzana, M. D. Skorokhvatov, B. Rossi, M. De Vincenzi, J. Maricic, L. Grandi, G. Zuzel, Laura Cadonati, M. E. Monzani, Yanhui Ma, D. Durben, M. Zehfus, B. J. Mount, Chung-Yao Yang, Augusto Brigatti, Lawrence Pinsky, A. Kayunov, R. B. Vogelaar, A. Meregaglia, S. Chidzik, C. Joliet, C. Condon, C. Ghiano, A. Pocar, N. Pelliccia, C. L. Kendziora, P. Saggese, A. Nelson, Sandra Zavatarelli, P. X. Li, O. Smirnov, S. Westerdale, Livia Ludhova, A. M. Goretti, A. S. Chepurnov, Thomas Alexander, S. Pordes, E. V. Hungerford, G. Koh, G. Guray, A. Sotnikov, Fausto Ortica, C. Guo, D. A. Semenov, R. Tartaglia, E. Pantic, K. Arisaka, G. Fiorillo, D. Korablev, I. Dratchnev, C. J. Martoff, Frank Calaprice, J. Brodsky, J. Tatarowicz, K. Keeter, Gioacchino Ranucci, Marcin Wójcik, D. Franco, W. Zhong, P. Cavalcante, Henning O. Back, G. Bonfini, P. Beltrame, P. D. Meyers, J. Thompson, An. Ianni, V. N. Muratova, L. Perasso, D. Alton, C. Salvo, S. Perasso, A.V. Etenko, R. Parsells, S. Davini, A. G. Cocco, Al. Ianni, Stefano Maria Mari, S. Luitz, Han Wang, P. J. Mosteiro, F. Gabriele, Jingke Xu, Cristiano Galbiati, D. Montanari, A. Fan, A. Empl, S. Kidner, S. V. Sukhotin, A. Wright, V. V. Kobychev, K. Lung, C. Love, T. Mohayai, A. Candela, S. D. Rountree, Paolo Lombardi, Aldo Romani, B Loer, A. V. Derbin, Y Suvarov, Jay Burton Benziger, T., Alexander, D., Alton, K., Arisaka, H. O., Back, P., Beltrame, J., Benziger, G., Bonfini, A., Brigatti, J., Brodsky, S., Bussino, L., Cadonati, F., Calaprice, A., Candela, H., Cao, P., Cavalcante, A., Chepurnov, S., Chidzik, A. G., Cocco, C., Condon, D., D'Angelo, S., Davini, M. D., Vincenzi, E. D., Haa, A., Derbin, G. D., Pietro, I., Dratchnev, D., Durben, A., Empl, A., Etenko, A., Fan, Fiorillo, Giuliana, D., Franco, K., Fomenko, G., Forster, F., Gabriele, C., Galbiati, S., Gazzana, C., Ghiano, A., Goretti, L., Grandi, M., Gromov, M., Guan, C., Guo, G., Guray, E. V., Hungerford, A., Ianni, C., Joliet, A., Kayunov, K., Keeter, C., Kendziora, S., Kidner, R., Klemmer, V., Kobychev, G., Koh, M., Komor, D., Korablev, G., Korga, P., Li, B., Loer, P., Lombardi, C., Love, L., Ludhova, S., Luitz, L., Lukyanchenko, A., Lund, K., Lung, Y., Ma, I., Machulin, S., Mari, J., Maricic, C. J., Martoff, A., Meregaglia, E., Meroni, P., Meyer, T., Mohayai, D., Montanari, M., Montuschi, M. E., Monzani, P., Mosteiro, B., Mount, V., Muratova, A., Nelson, A., Nemtzow, N., Nurakhov, M., Orsini, F., Ortica, M., Pallavicini, E., Pantic, S., Parmeggiano, R., Parsell, N., Pelliccia, L., Perasso, S., Perasso, Perfetto, Francesco, L., Pinsky, A., Pocar, S., Porde, K., Randle, G., Ranucci, A., Razeto, A., Romani, B., Rossi, N., Rossi, S. D., Rountree, P., Saggese, R., Saldanha, C., Salvo, W., Sand, M., Seigar, D., Semenov, E., Shield, M., Skorokhvatov, O., Smirnov, A., Sotnikov, S., Sukhotin, Y., Suvarov, R., Tartaglia, J., Tatarowicz, G., Testera, J., Thompson, A., Tonazzo, E., Unzhakov, R. B., Vogelaar, H., Wang, S., Westerdale, M., Wojcik, A., Wright, J., Xu, C., Yang, S., Zavatarelli, M., Zehfu, W., Zhong, G., Zuzel, Physics Department, Amherst U., University of Massachusetts System (UMASS), Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Régulation de l'expression génétique chez les microorganismes (REGCM), Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Kastler Brossel (LKB (Jussieu)), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), departement de physique, Albert-Ludwigs-Universität Freiburg, SLAC National Accelerator Laboratory (SLAC), Stanford University, Anhui University [Hefei], Physics Department, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Department of Geological Sciences, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kavli Institute for Particle Astrophysics and Cosmology (KIPAC), Università degli studi di Genova = University of Genoa (UniGe), Departamento de Engenharia Elétrica [Minas Gerais] (DEE - UFMG), Universidade Federal de Minas Gerais, Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Rhodes University, Grahamstown, EAST CHINA UNIVERSITY, KEY LAB, Institute of Physics, Polish Academy of Sciences, Polska Akademia Nauk = Polish Academy of Sciences (PAN), International Iberian Nanotechnology Laboratory (INL), Centre de Recherche en Information Biomédicale sino-français (CRIBS), Université de Rennes (UR)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Européen des membranes (IEM), Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Alexander, T, Alton, D, Arisaka, K, Back, Ho, Beltrame, P, Benziger, J, Bonfini, G, Brigatti, A, Brodsky, J, Bussino, Severino Angelo Maria, Cadonati, L, Calaprice, F, Candela, A, Cao, H, Cavalcante, P, Chepurnov, A, Chidzik, S, Cocco, Ag, Condon, C, D'Angelo, D, Davini, S, DE VINCENZI, Mario, De Haas, E, Derbin, A, Di Pietro, G, Dratchnev, I, Durben, D, Empl, A, Etenko, A, Fan, A, Fiorillo, G, Franco, D, Fomenko, K, Forster, G, Gabriele, F, Galbiati, C, Gazzana, S, Ghiano, C, Goretti, A, Grandi, L, Gromov, M, Guan, M, Guo, C, Guray, G, Hungerford, Ev, Ianni, Al, Ianni, An, Joliet, C, Kayunov, A, Keeter, K, Kendziora, C, Kidner, S, Klemmer, R, Kobychev, V, Koh, G, Komor, M, Korablev, D, Korga, G, Li, P, Loer, B, Lombardi, P, Love, C, Ludhova, L, Luitz, S, Lukyanchenko, L, Lund, A, Lung, K, Ma, Y, Machulin, I, Mari, Stefano Maria, Maricic, J, Martoff, Cj, Meregaglia, A, Meroni, E, Meyers, P, Mohayai, T, Montanari, D, Montuschi, M, Monzani, Me, Mosteiro, P, Mount, B, Muratova, V, Nelson, A, Nemtzow, A, Nurakhov, N, Orsini, M, Ortica, F, Pallavicini, M, Pantic, E, Parmeggiano, S, Parsells, R, Pelliccia, N, Perasso, L, Perasso, S, Perfetto, F, Pinsky, L, Pocar, A, Pordes, S, Randle, K, Ranucci, G, Razeto, A, Romani, A, Rossi, B, Rossi, N, Rountree, Sd, Saggese, P, Saldanha, R, Salvo, C, Sands, W, Seigar, M, Semenov, D, Shields, E, Skorokhvatov, M, Smirnov, O, Sotnikov, A, Sukhotin, S, Suvarov, Y, Tartaglia, R, Tatarowicz, J, Testera, G, Thompson, J, Tonazzo, A, Unzhakov, E, Vogelaar, Rb, Wang, H, Westerdale, S, Wojcik, M, Wright, A, Xu, J, Yang, C, Zavatarelli, S, Zehfus, M, Zhong, W, Zuzel, G., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Dip. di Fisica dell'Università di Genova - Italy, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)

Subjects
Physics::Instrumentation and Detectors, Dark matter, chemistry.chemical_element, 7. Clean energy, 01 natural sciences, Nuclear physics, 0103 physical sciences, Neutron, Dark Matter detector, 010306 general physics, Instrumentation, Mathematical Physics, ComputingMilieux_MISCELLANEOUS, Event reconstruction, Physics, [PHYS]Physics [physics], Scintillation, Argon, Time projection chamber, 010308 nuclear & particles physics, Detector, chemistry, Scintillation counter, High Energy Physics::Experiment, Noble liquid detector, DarkSide detector, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

"The DarkSide staged program utilizes a two-phase time projection chamber (TPC) with liquid argon as the target material for the scattering of dark matter particles. Efficient background reduction is achieved using low radioactivity underground argon as well as several experimental handles such as pulse shape, ratio of ionization over scintillation signal, 3D event reconstruction, and active neutron and muon vetos. The DarkSide-10 prototype detector has proven high scintillation light yield, which is a particularly important parameter as it sets the energy threshold for the pulse shape discrimination technique. The DarkSide-50 detector system, currently in commissioning phase at the Gran Sasso Underground Laboratory, will reach a sensitivity to dark matter spin-independent scattering cross section of 10(-45) cm(2) within 3 years of operation."

Published
2013

19. Limits on spin-dependent WIMP-nucleon cross sections from 225 live days of XENON100 data

Author

Marc Schumann, P. Shagin, A. Behrens, Ehud Duchovni, E. Pantic, M. Messina, J. A. M. Lopes, A. Kish, M. Garbini, K. Arisaka, Jean-Pierre Cussonneau, Hardy Simgen, A. D. Ferella, D. Thers, Boris Bauermeister, R. F. Lang, João Cardoso, K. Lung, A. P. Colijn, T. Marrodán Undagoitia, Ch. Weinheimer, Laura Baudis, Hui Wang, F. Gao, M. P. Decowski, Manfred Lindner, C. Ghag, C. Levy, M. Selvi, W. T. Chen, J. Lamblin, H. Landsman, Daniel Lellouch, P. R. Scovell, H. Contreras, P. Beltrame, Florian Kaether, Kaixuan Ni, Ran Budnik, F. V. Massoli, A. Molinario, Qing Lin, B. Choi, J.M.F. dos Santos, L. Scotto Lavina, Sebastian Lindemann, S. Rosendahl, S. Fattori, A. Teymourian, N. Priel, C. Balan, W. Hampel, Karl Giboni, W. Fulgione, Ethan Brown, Elena Aprile, F. Arneodo, April S. Brown, Uwe Oberlack, K. E. Lim, Jochen Schreiner, C. Grignon, A. J. Melgarejo Fernandez, M. Le Calloch, M. Alfonsi, O. Vitells, A. Rizzo, S. E. A. Orrigo, Y. Meng, Giacomo Bruno, G. Sartorelli, M. Weber, G. Plante, Luke Goetzke, K. Bokeloh, E. K. U. Gross, R. Persiani, Astroparticle Physics (IHEF, IoP, FNWI), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), XENON100, E. Aprile, M. Alfonsi, K. Arisaka, F. Arneodo, C. Balan, L. Baudi, B. Bauermeister, A. Behren, P. Beltrame, K. Bokeloh, A. Brown, E. Brown, G. Bruno, R. Budnik, J. M. R. Cardoso, W.-T. Chen, B. Choi, A. P. Colijn, H. Contrera, J. P. Cussonneau, M. P. Decowski, E. Duchovni, S. Fattori, A. D. Ferella, W. Fulgione, F. Gao, M. Garbini, C. Ghag, K.-L. Giboni, L. W. Goetzke, C. Grignon, E. Gro, W. Hampel, F. Kaether, A. Kish, J. Lamblin, H. Landsman, R. F. Lang, M. Le Calloch, D. Lellouch, C. Levy, K. E. Lim, Q. Lin, S. Lindemann, M. Lindner, J. A. M. Lope, K. Lung, T. Marrodán Undagoitia, F. V. Massoli, A. J. Melgarejo Fernandez, Y. Meng, M. Messina, A. Molinario, K. Ni, U. Oberlack, S. E. A. Orrigo, E. Pantic, R. Persiani, G. Plante, N. Priel, A. Rizzo, S. Rosendahl, J. M. F. dos Santo, G. Sartorelli, J. Schreiner, M. Schumann, L. Scotto Lavina, P. R. Scovell, M. Selvi, P. Shagin, H. Simgen, A. Teymourian, D. Ther, O. Vitell, H. Wang, M. Weber, C. Weinheimer, and XENON100 collaboration

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Dark matter, General Physics and Astronomy, FOS: Physical sciences, 01 natural sciences, dark matter, Particle detector, High Energy Physics - Experiment, Nuclear physics, Cross section (physics), High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), WIMP, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 010306 general physics, Pseudovector, Instrumentation and Methods for Astrophysics (astro-ph.IM), Spin-½, Physics, 010308 nuclear & particles physics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], High Energy Physics - Phenomenology, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], Astrophysics - Instrumentation and Methods for Astrophysics, Nucleon, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present new experimental constraints on the elastic, spin-dependent WIMP-nucleon cross section using recent data from the XENON100 experiment, operated in the Laboratori Nazionali del Gran Sasso in Italy. An analysis of 224.6 live days x 34 kg of exposure acquired during 2011 and 2012 revealed no excess signal due to axial-vector WIMP interactions with 129-Xe and 131-Xe nuclei. This leads to the most stringent upper limits on WIMP-neutron cross sections for WIMP masses above 6 GeV, with a minimum cross section of 3.5 x 10^{-40} cm^2 at a WIMP mass of 45 GeV, at 90% confidence level., Comment: 5 pages, 3 figures; corrected caption of figure 3

Published
2013

20. The distributed Slow Control System of the XENON100 experiment

Author

Y. Mei, E. Pantic, Jean-Pierre Cussonneau, F. V. Massoli, Qing Lin, A. Manzur, K. E. Lim, O. Vitells, A. C. C. Ribeiro, Giacomo Bruno, W. Fulgione, A. Rizzo, B. Choi, J. A. M. Lopes, L. Scotto Lavina, A. Kish, Ethan Brown, Gabriella Sartorelli, E. Duchovni, Laura Baudis, W. Hampel, A. D. Ferella, M. Weber, S. E. A. Orrigo, João Cardoso, M. Selvi, F. Gao, G. Plante, T. Marrodán Undagoitia, Kaixuan Ni, Ch. Weinheimer, P. Beltrame, R. Persiani, Hui Wang, W. T. Chen, S. Rosendahl, Marc Schumann, P. Shagin, A. Molinario, A. Teymourian, K. Arisaka, H. Simgen, Uwe Oberlack, P. R. Scovell, S. Fattori, Daniel McKinsey, H. Contreras, F. Arneodo, M. Garbini, Eilam Gross, Luke Goetzke, A. Behrens, K. Bokeloh, Y. Meng, Elena Aprile, E. Nativ, Ran Budnik, A. J. Melgarejo Fernandez, K. Lung, C. Levy, M. Alfonsi, J.M.F. dos Santos, R. F. Lang, M. Le Calloch, Stefan Lindemann, J. Lamblin, J. Schreiner, M. P. Decowski, Manfred Lindner, C. Balan, N. Priel, D. Thers, C. Grignon, K. L. Giboni, J. V. Patricio, E Aprile, M Alfonsi, K Arisaka, F Arneodo, C Balan, L Baudi, A Behren, P Beltrame, K Bokeloh, E Brown, G M Bruno, R Budnik, M Le Calloch, J M Cardoso, W -T Chen, B Choi, H Contrera, J -P Cussonneau, M P Decowski, E Duchovni, S Fattori, A D Ferella, W Fulgione, F Gao, M Garbini, K -L Giboni, L W Goetzke, C Grignon, E Gro, W Hampel, D N McKinsey, A Kish, J Lamblin, R F Lang, C Levy, K E Lim, Q Lin, S Lindemann, M Lindner, J A M Lope, K Lung, A Manzur, T Marrodán Undagoitia, F V Massoli, Y Mei, A J Melgarejo Fernandez, Y Meng, A Molinario, E Nativ, K Ni, U Oberlack, S E A Orrigo, E Pantic, J V Patricio, R Persiani, G Plante, N Priel, A C C Ribeiro, A Rizzo, S Rosendahl, J M F dos Santo, G Sartorelli, J Schreiner, M Schumann, L Scotto Lavina, P R Scovell, M Selvi, P Shagin, H Simgen, A Teymourian, D Ther, O Vitell, H Wang, M Weber, C Weinheimer, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), XENON100, IoP (FNWI), Gravitation and Astroparticle Physics Amsterdam, GRAPPA (ITFA, IoP, FNWI), Faculty of Science, and Other Research IHEF (IoP, FNWI)

Subjects
Physics - Instrumentation and Detectors, architecture, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Java, Computer science, Real-time computing, FOS: Physical sciences, chemistry.chemical_element, Control and monitor systems online, Control systems, Detector control systems (detector and experiment monitoring and slow-control systems, architecture, hardware, algorithms, databases), algorithms, 01 natural sciences, Xenon, 0103 physical sciences, hardware, DETECTOR CONTROL SYSTEMS, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], CONTROL SYSTEMS, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, Mathematical Physics, computer.programming_language, Time projection chamber, 010308 nuclear & particles physics, business.industry, Detector control systems (detector and experiment monitoring and slow-control systems, Emphasis (telecommunications), Volume (computing), Instrumentation and Detectors (physics.ins-det), Modular design, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], chemistry, Control system, Astrophysics - Instrumentation and Methods for Astrophysics, databases), business, computer, System software
Abstract

The XENON100 experiment, in operation at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, was designed to search for evidence of dark matter interactions inside a volume of liquid xenon using a dual-phase time projection chamber. This paper describes the Slow Control System (SCS) of the experiment with emphasis on the distributed architecture as well as on its modular and expandable nature. The system software was designed according to the rules of Object-Oriented Programming and coded in Java, thus promoting code reusability and maximum flexibility during commissioning of the experiment. The SCS has been continuously monitoring the XENON100 detector since mid 2008, remotely recording hundreds of parameters on a few dozen instruments in real time, and setting emergency alarms for the most important variables., Comment: 12 pages, 4 figures

Published
2012

21. Dark Matter Results from 100 Live Days of XENON100 Data

Author

K. Arisaka, Marc Schumann, P. Shagin, F. Arneodo, J. A. M. Lopes, A. Kish, G. Sartorelli, K. E. Lim, R. Santorelli, Manfred Lindner, C. W. Lam, K. Bokeloh, S. Fattori, A. Behrens, M. Selvi, J. Lamblin, Eilam Gross, Elena Aprile, David B. Cline, D. Thers, Y. Mei, E. Pantic, R. F. Lang, A. Teymourian, R. Persiani, Ethan Brown, T. Bruch, K. L. Giboni, Hardy Simgen, A. D. Ferella, Hongwei Wang, M. Weber, T. Marrodán Undagoitia, C. Levy, Ch. Weinheimer, B. Choi, G. Plante, K. Lung, Laura Baudis, J.M.F. dos Santos, Sebastian Lindemann, Kaixuan Ni, A. J. Melgarejo Fernandez, S. E. A. Orrigo, A. C. C. Ribeiro, Giacomo Bruno, O. Vitells, Uwe Oberlack, Qing Lin, Ehud Duchovni, A. Askin, João Cardoso, F. Gao, W. T. Chen, E. Aprile, K. Arisaka, F. Arneodo, A. Askin, L. Baudi, A. Behren, K. Bokeloh, E. Brown, T. Bruch, G. Bruno, J. M. R. Cardoso, W.-T. Chen, B. Choi, D. Cline, E. Duchovni, S. Fattori, A. D. Ferella, F. Gao, K.-L. Giboni, E. Gro, A. Kish, C. W. Lam, J. Lamblin, R. F. Lang, C. Levy, K. E. Lim, Q. Lin, S. Lindemann, M. Lindner, J. A. M. Lope, K. Lung, T. Marrodan Undagoitia, Y. Mei, A. J. Melgarejo Fernandez, K. Ni| U. Oberlack, S. E. A. Orrigo, E. Pantic, R. Persiani, G. Plante, A. C. C. Ribeiro, R. Santorelli, J. M. F. dos Santo, G. Sartorelli, M. Schumann, M. Selvi, P. Shagin, H. Simgen, A. Teymourian, D. Ther, O. Vitell, H. Wang, M. Weber, C. Weinheimer, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and XENON100

Subjects
Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Large Underground Xenon experiment, 010308 nuclear & particles physics, DARK MATTER, Dark matter, Hadron, FOS: Physical sciences, General Physics and Astronomy, Elementary particle, Fermion, 01 natural sciences, Particle detector, High Energy Physics - Experiment, WIMPS, Nuclear physics, High Energy Physics - Experiment (hep-ex), XENON, WIMP, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], TPC, 010306 general physics, Nucleon, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present results from the direct search for dark matter with the XENON100 detector, installed underground at the Laboratori Nazionali del Gran Sasso of INFN, Italy. XENON100 is a two-phase time projection chamber with a 62 kg liquid xenon target. Interaction vertex reconstruction in three dimensions with millimeter precision allows to select only the innermost 48 kg as ultra-low background fiducial target. In 100.9 live days of data, acquired between January and June 2010, no evidence for dark matter is found. Three candidate events were observed in a pre-defined signal region with an expected background of 1.8 +/- 0.6 events. This leads to the most stringent limit on dark matter interactions today, excluding spin-independent elastic WIMP-nucleon scattering cross-sections above 7.0x10^-45 cm^2 for a WIMP mass of 50 GeV/c^2 at 90% confidence level., 5 pages, 5 figures; matches accepted version

Published
2011

22. Implications on inelastic dark matter from 100 live days of XENON100 data

Author

E. Pantic, Ethan Brown, M. Selvi, David B. Cline, Y. Mei, J.M.F. dos Santos, Hui Wang, T. Marrodán Undagoitia, Manfred Lindner, Ch. Weinheimer, B. Choi, A. Behrens, Sebastian Lindemann, Karl Giboni, K. Arisaka, R. Santorelli, F. Arneodo, M. Weber, G. Plante, Hardy Simgen, A. D. Ferella, S. Fattori, J. A. M. Lopes, K. Lung, A. Kish, Laura Baudis, A. Teymourian, C. W. Lam, D. Thers, R. F. Lang, A. C. C. Ribeiro, Giacomo Bruno, Elena Aprile, C. Levy, T. Bruch, Kaixuan Ni, K. E. Lim, S. E. A. Orrigo, J. Lamblin, Uwe Oberlack, O. Vitells, Ehud Duchovni, A. J. Melgarejo Fernandez, Qing Lin, A. Askin, João Cardoso, F. Gao, W. T. Chen, Marc Schumann, P. Shagin, G. Sartorelli, R. Persiani, K. Bokeloh, E. K. U. Gross, E. Aprile, K. Arisaka, F. Arneodo, A. Askin, L. Baudi, A. Behren, K. Bokeloh, E. Brown, T. Bruch, G. Bruno, J. M. R. Cardoso, W.-T. Chen, B. Choi, D. Cline, E. Duchovni, S. Fattori, A. D. Ferella, F. Gao, K.-L. Giboni, E. Gro, A. Kish, C. W. Lam, J. Lamblin, R. F. Lang, C. Levy, K. E. Lim, Q. Lin, S. Lindemann, M. Lindner, J. A. M. Lope, K. Lung, T. Marrodán Undagoitia, Y. Mei, A. J. Melgarejo Fernandez, K. Ni, U. Oberlack, S. E. A. Orrigo, E. Pantic, R. Persiani, G. Plante, A. C. C. Ribeiro, R. Santorelli, J. M. F. dos Santo, G Sartorelli, M. Schumann, M. Selvi, P. Shagin, H. Simgen, A. Teymourian, D. Ther, O. Vitell, H. Wang, M. Weber, C. Weinheimer, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and XENON100

Subjects
Physics, Nuclear and High Energy Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), 010308 nuclear & particles physics, Scattering, DARK MATTER, Signal region, Dark matter, FOS: Physical sciences, 01 natural sciences, WIMPS, Nuclear physics, XENON, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], TPC, 010306 general physics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The XENON100 experiment has recently completed a dark matter run with 100.9 live-days of data, taken from January to June 2010. Events in a 48kg fiducial volume in the energy range between 8.4 and 44.6 keVnr have been analyzed. A total of three events have been found in the predefined signal region, compatible with the background prediction of (1.8 \pm 0.6) events. Based on this analysis we present limits on the WIMP-nucleon cross section for inelastic dark matter. With the present data we are able to rule out the explanation for the observed DAMA/LIBRA modulation as being due to inelastic dark matter scattering off iodine at a 90% confidence level., Comment: 3 pages, 3 figures

Published
2011

24. Light yield in DarkSide-10 : a prototype two-phase argon TPC for dark matter searches

Author

M. D. Skorokhvatov, L. Grandi, Marc S. Seigar, A. G. Cocco, A. Fan, Aldo Romani, S. Kidner, I. N. Machulin, C. Salvo, E. de Haas, D. Semenov, A. Nelson, N. Rossi, Marco Pallavicini, K. Arisaka, D. D'Angelo, E. V. Hungerford, E. V. Unzhakov, G. Fiorillo, Y. Meng, C. Ghag, G. Guray, A. Sotnikov, J. Thompson, G. Bonfini, C. L. Kendziora, W. Sands, F. Gabriele, R. B. Vogelaar, J. Brodsky, P. Saggese, C. Condon, P. Beltrame, S. Davini, B. J. Mount, C. Ghiano, M. Guan, A. Candela, P. J. Mosteiro, David B. Cline, R. Tartaglia, E. Meroni, H. O. Back, K. Keeter, S. Gazzana, M. Zehfus, Peter Daniel Meyers, An. Ianni, Laura Cadonati, F. Perfetto, A. Nemtzow, D. Korablev, Y. Suvorov, S. Westerdale, Hui Wang, A. V. Derbin, A. Brigatti, G. Koh, M. Montuschi, Livia Ludhova, V. N. Muratova, Thomas Alexander, I. Dratchnev, Y. Q. Ma, A. M. Goretti, A. Razeto, N. N. Nurakhov, R. Saldanha, A. S. Chepurnov, C. J. Martoff, J. Tatarowicz, G. Testera, Frank Calaprice, A. E. Chavarria, Cristiano Galbiati, L. Lukyanchenko, G. Zuzel, Fausto Ortica, M. Orsini, C. Guo, Al. Ianni, A. Teymourian, L. Perasso, H. Cao, Gioacchino Ranucci, W. Zhong, Sandra Zavatarelli, G. Korga, P. X. Li, D. Alton, A.V. Etenko, E. Pantic, Austin P. Lund, M. Gromov, R. Parsells, P. Cavalcante, G. Di Pietro, A. Empl, N. Pelliccia, J. Maricic, E. Shields, C. Love, T. Mohayai, Paolo Lombardi, S. V. Sukhotin, A. Wright, V. V. Kobychev, K. Lung, B. Loer, Jay Burton Benziger, Chung-Yao Yang, Lawrence Pinsky, A. Kayunov, D. Montanari, D. Durben, A. Pocar, Jilei Xu, O. Smirnov, S. Parmeggiano, Marcin Wójcik, S. Pordes, K. Fomenko, Alexander, T., Alton, D., Arisaka, K., Back, H. O., Beltrame, P., Benziger, J., Bonfini, G., Brigatti, A., Brodsky, J., Cadonati, L., Calaprice, F., Candela, A., Cao, H., Cavalcante, P., Chavarria, A., Chepurnov, A., Cline, D., Cocco, A. G., Condon, C., D'Angelo, D., Davini, S., Haas, E. D., Derbin, A., Pietro, G. D., Dratchnev, I., Durben, D., Empl, A., Etenko, A., Fan, A., Fiorillo, Giuliana, Fomenko, K., Gabriele, F., Galbiati, C., Gazzana, S., Ghag, C., Ghiano, C., Goretti, A., Grandi, L., Gromov, M., Guan, M., Guo, C., Guray, G., Hungerford, E. V., Ianni, A., Kayunov, A., Keeter, K., Kendziora, C., Kidner, S., Kobychev, V., Koh, G., Korablev, D., Korga, G., Shields, E., Li, P., Loer, B., Lombardi, P., Love, C., Ludhova, L., Lukyanchenko, L., Lund, A., Lung, K., Ma, Y., Machulin, I., Maricic, J., Martoff, C. J., Meng, Y., Meroni, E., Meyers, P. D., Mohayai, T., Montanari, D., Montuschi, M., Mosteiro, P., Mount, B., Muratova, V., Nelson, A., Nemtzow, A., Nurakhov, N., Orsini, M., Ortica, F., Pallavicini, M., Pantic, E., Parmeggiano, S., Parsells, R., Pelliccia, N., Perasso, L., Perfetto, F., Pinsky, L., Pocar, A., Pordes, S., Ranucci, G., Razeto, A., Romani, A., Rossi, N., Saggese, P., Saldanha, R., Salvo, C., Sands, W., Seigar, M., Semenov, D., Skorokhvatov, M., Smirnov, O., Sotnikov, A., Sukhotin, S., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Teymourian, A., Thompson, J., Unzhakov, E., Vogelaar, R. B., Wang, H., Westerdale, S., Wojcik, M., Wright, A., Xu, J., Yang, C., Zavatarelli, S., Zehfus, M., Zhong, W., and Zuzel, G.

Subjects
Physics::Instrumentation and Detectors, Dark matter, light yield, FOS: Physical sciences, chemistry.chemical_element, dark matter, law.invention, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), XENON, law, DEPENDENCE, LIQUID ARGON, PARTICLES, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Scintillation, Time projection chamber, Argon, Gamma ray, Astronomy and Astrophysics, Laser, time projection chamber, chemistry, Yield (chemistry), Scintillation counter, argon, High Energy Physics::Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, photoelectron yield
Abstract

As part of the DarkSide program of direct dark matter searches using liquid argon TPCs, a prototype detector with an active volume containing 10 kg of liquid argon, DarkSide-10, was built and operated underground in the Gran Sasso National Laboratory in Italy. A critically important parameter for such devices is the scintillation light yield, as photon statistics limits the rejection of electron-recoil backgrounds by pulse shape discrimination. We have measured the light yield of DarkSide-10 using the readily-identifiable full-absorption peaks from gamma ray sources combined with single-photoelectron calibrations using low-occupancy laser pulses. For gamma lines of energies in the range 122-1275 keV, we get consistent light yields averaging 8.887+-0.003(stat)+-0.444(sys) p.e./keVee. With additional purification, the light yield measured at 511 keV increased to 9.142+-0.006(stat) p.e./keVee., 10 pages, 7 figures, Accepted for publication in Astroparticle Physics

Published
2013

25. The neutron background of the XENON100 dark matter search experiment

Author

A. J. Melgarejo Fernandez, M. Alfonsi, Laura Baudis, P. Beltrame, Ehud Duchovni, S. E. A. Orrigo, João Cardoso, F. Gao, M. Garbini, M. Selvi, Luke Goetzke, E. Tziaferi, Kaixuan Ni, B. Choi, H. Contreras, P. Shagin, Elena Aprile, M. Weber, J. A. M. Lopes, A. Kish, Gabriella Sartorelli, H. Landsman, S. Rosendahl, L. Scotto Lavina, M. Le Calloch, K. E. Lim, P. R. Scovell, A. Molinario, M. P. Decowski, C. Levy, Manfred Lindner, W. Hampel, K. Lung, A. P. Colijn, S. Fattori, O. Vitells, J.M.F. dos Santos, Hui Wang, Ethan Brown, A. Rizzo, J. Lamblin, M. Messina, Uwe Oberlack, K. Arisaka, Sebastian Lindemann, April S. Brown, Karl Giboni, Guillaume Plante, Florian Kaether, F. V. Massoli, Jochen Schreiner, Qing Lin, Boris Bauermeister, Y. Meng, A. Behrens, Giacomo Bruno, W. Fulgione, E. Pantic, Jean-Pierre Cussonneau, Ran Budnik, C. Balan, Marc Schumann, N. Priel, A. Teymourian, D. Thers, R. F. Lang, Hardy Simgen, A. D. Ferella, F. Arneodo, T. Marrodán Undagoitia, Ch. Weinheimer, C. Ghag, W. T. Chen, C. Grignon, R. Persiani, K. Bokeloh, E. K. U. Gross, National Science Foundation (US), German Research Foundation, Aprile, E., Alfonsi, M., Arisaka, K., Arneodo, F., Balan, C., Baudis, L., Bauermeister, B., Behrens, A., Beltrame, P., Bokeloh, K., Brown, A., Brown, E., Bruno, G., Budnik, R., Cardoso, J.M.R., Chen, W.-T., Choi, B., Colijn, A.P., Contreras, H., Cussonneau, J.P., Decowski, M.P., Duchovni, E., Fattori, S., Ferella, A.D., Fulgione, W., Gao, F., Garbini, M., Ghag, C., Giboni, K.-L., Goetzke, L.W., Grignon, C., Gross, E., Hampel, W., Kaether, F., Kish, A., Lamblin, J., Landsman, H., Lang, R.F., Le Calloch, M., Levy, C., Lim, K.E., Lin, Q., Lindemann, S., Lindner, M., Lopes, J.A.M., Lung, K., Undagoitia, T. Marrodán, Massoli, F.V., Fernandez, A. J. Melgarejo, Meng, Y., Messina, M., Molinario, A., Ni, K., Oberlack, U., Orrigo, S.E.A., Pantic, E., Persiani, R., Plante, G., Priel, N., Rizzo, A., Rosendahl, S., Santos, J. M. F. Do, Sartorelli, G., Schreiner, J., Schumann, M., Lavina, L Scotto, Scovell, P.R., Selvi, M., Shagin, P., Simgen, H., Teymourian, A., Thers, D., Tziaferi, E., Vitells, O., Wang, H., Weber, M., Weinheimer, C., Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), IHEF (IoP, FNWI), Faculty of Science, Other Research IHEF (IoP, FNWI), Gravitation and Astroparticle Physics Amsterdam, IoP (FNWI), and GRAPPA (ITFA, IoP, FNWI)

Subjects
Nuclear and High Energy Physics, Particle physics, Large Underground Xenon experiment, Physics::Instrumentation and Detectors, Dark matter, Geant4, Astrophysics::Cosmology and Extragalactic Astrophysics, WIMP Argon Programme, 01 natural sciences, Nuclear physics, WIMP, Nuclear and High Energy Physics Neutron Background Dark Matter Search XENON TPC, 0103 physical sciences, Neutron, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Nuclear Experiment, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), ComputingMilieux_MISCELLANEOUS, Spontaneous fission, Physics, Elastic scattering, Flux, Muons, 010308 nuclear & particles physics, Astrophysics::Instrumentation and Methods for Astrophysics, Detectors, Weakly interacting massive particles, High Energy Physics::Experiment, Simulation
Abstract

TheXENON100 experiment, installed underground at the LaboratoriNazionali del Gran Sasso, aims to directly detect dark matter in the form of weakly interacting massive particles (WIMPs) via their elastic scattering off xenon nuclei. This paper presents a study on the nuclear recoil background of the experiment, taking into account neutron backgrounds from (alpha, n) reactions and spontaneous fission due to natural radioactivity in the detector and shield materials, as well as muon-induced neutrons. Based on MonteCarlo simulations and using measured radioactive contaminations of all detector components, we predict the nuclear recoil backgrounds for the WIMP search results published by theXENON100 experiment in 2011 and 2012, 0.11(-0.04)(+0.08) events and 0.17(-0.07)(+0.12) events, respectively, and conclude that they do not limit the sensitivity of the experiment., We gratefully acknowledge support from NSF, DOE, SNF, UZH, FCT, Region des Pays de la Loire, STCSM, NSFC, DFG, Stichting voor Fundamenteel Onderzoek der Materie (FOM), the Max Planck Society and the Weizmann Institute of Science. We are grateful to LNGS for hosting and supporting XENON100.

Published
2013

26. Krüppel-like factor 2 is required for normal mouse cardiac development

Author

Tina K. Lung, Rakesh C. Kukreja, Joyce A. Lloyd, Fadi N Salloum, Yousef N. Alhashem, Benjamin A. Koppenhaver, Aditi R. Chiplunkar, and Jack L. Haar

Subjects
Male, Embryology, Mouse, Gene Expression, lcsh:Medicine, Matrix (biology), Cardiovascular, Mice, Molecular Cell Biology, Morphogenesis, lcsh:Science, reproductive and urinary physiology, Glycosaminoglycans, Mice, Knockout, 0303 health sciences, Multidisciplinary, Cardiac Jelly, Heart development, GATA4, 030302 biochemistry & molecular biology, Gene Expression Regulation, Developmental, Embryo, Cell Differentiation, Heart, Animal Models, KLF2, embryonic structures, Heart Development, Medicine, Female, Cellular Types, Research Article, Heart Defects, Congenital, endocrine system, Kruppel-Like Transcription Factors, Mice, Transgenic, SOX9, Biology, 03 medical and health sciences, Model Organisms, Genetics, Animals, 030304 developmental biology, Myocardium, Mesenchymal stem cell, lcsh:R, Endothelial Cells, Embryo, Mammalian, Molecular biology, GATA4 Transcription Factor, Mice, Inbred C57BL, Immunology, lcsh:Q, Gene Function, T-Box Domain Proteins, Developmental Biology
Abstract

Kruppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death by mouse embryonic day 14.5 (E14.5) in a mixed genetic background. This work identifies an earlier and more fundamental role for KLF2 in mouse cardiac development in FVB/N mice. FVB/N KLF2−/− embryos die earlier, by E11.5. E9.5 FVB/N KLF2−/− hearts have multiple, disorganized cell layers lining the AV cushions, the primordia of the AV valves, rather than the normal single layer. By E10.5, traditional and endothelial-specific FVB/N KLF2−/− AV cushions are hypocellular, suggesting that the cells accumulating at the AV canal have a defect in endothelial to mesenchymal transformation (EMT). E10.5 FVB/N KLF2−/− hearts have reduced glycosaminoglycans in the cardiac jelly, correlating with the reduced EMT. However, the number of mesenchymal cells migrating from FVB/N KLF2−/− AV explants into a collagen matrix is reduced considerably compared to wild-type, suggesting that the EMT defect is not due solely to abnormal cardiac jelly. Echocardiography of E10.5 FVB/N KLF2−/− embryos indicates that they have abnormal heart function compared to wild-type. E10.5 C57BL/6 KLF2−/− hearts have largely normal AV cushions. However, E10.5 FVB/N and C57BL/6 KLF2−/− embryos have a delay in the formation of the atrial septum that is not observed in a defined mixed background. KLF2 ablation results in reduced Sox9, UDP-glucose dehydrogenase (Ugdh), Gata4 and Tbx5 mRNA in FVB/N AV canals. KLF2 binds to the Gata4, Tbx5 and Ugdh promoters in chromatin immunoprecipitation assays, indicating that KLF2 could directly regulate these genes. In conclusion, KLF2−/− heart phenotypes are genetic background-dependent. KLF2 plays a role in EMT through its regulation of important cardiovascular genes.

Published
2013

27. Observation and applications of single-electron charge signals in the XENON100 experiment

Author

F. V. Massoli, Qing Lin, W. Fulgione, Y. Meng, H. Landsman, Uwe Oberlack, M. Garbini, João Cardoso, B. Choi, F. Gao, W. T. Chen, S. E. A. Orrigo, M. Messina, K. Arisaka, A. Behrens, M. Weber, Auke-Pieter Colijn, K. E. Lim, F. Piastra, S. Fattori, Abbe Brown, G. Kessler, G. Plante, W. Hampel, O. Vitells, R. Persiani, R. Itay, J. Naganoma, F. Arneodo, M. Selvi, A. J. Melgarejo Fernandez, Kaixuan Ni, Hui Wang, E. Pantic, H. Simgen, M. Le Calloch, M. Alfonsi, C. Grignon, K. L. Giboni, Florian Kaether, Boris Bauermeister, C. Balan, J. A. M. Lopes, A. Kish, Elena Aprile, Eilam Gross, Giacomo Bruno, T. Marrodán Undagoitia, Luke Goetzke, S. Bruenner, Ch. Weinheimer, C. Ghag, K. Bokeloh, C. Levy, J. Schreiner, M. P. Decowski, H. Contreras, Manfred Lindner, R. F. Lang, A. Molinario, N. Priel, Jean-Pierre Cussonneau, P. Beltrame, S. Rosendahl, A. Teymourian, A. Rizzo, Ethan Brown, Marc Schumann, P. Shagin, J. Lamblin, D. Thers, E. Duchovni, Laura Baudis, Ran Budnik, Gabriella Sartorelli, L. Scotto Lavina, K. Lung, A. D. Ferella, J.M.F. dos Santos, Sebastian Lindemann, E Aprile, M Alfonsi, K Arisaka, F Arneodo, C Balan, L Baudi, B Bauermeister, A Behren, P Beltrame, K Bokeloh, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, J M R Cardoso, W-T Chen, B Choi, A P Colijn, H Contrera, J P Cussonneau, M P Decowski, E Duchovni, S Fattori, A D Ferella, W Fulgione, F Gao, M Garbini, C Ghag, K-L Giboni, L W Goetzke, C Grignon, E Gro, W Hampel, R Itay, F Kaether, G Kessler, A Kish, J Lamblin, H Landsman, R F Lang, M Le Calloch, C Levy, K E Lim, Q Lin, S Lindemann, M Lindner, J A M Lope, K Lung, T Marrodán Undagoitia, F V Massoli, A J Melgarejo Fernandez, Y Meng, M Messina, A Molinario, J Naganoma, K Ni, U Oberlack, S E A Orrigo, E Pantic, R Persiani, F Piastra, G Plante, N Priel, A Rizzo, S Rosendahl, J M F dos Santo, G Sartorelli, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, H Simgen, A Teymourian, D Ther, O Vitell, H Wang, M Weber, C Weinheimer, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), XENON100, Astroparticle Physics (IHEF, IoP, FNWI), and The XENON100 collaboration

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Drift velocity, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Physics::Instrumentation and Detectors, Dark matter, chemistry.chemical_element, FOS: Physical sciences, double phase TPC, 01 natural sciences, dark matter, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Xenon, WIMP, photoionization, single electron, xenon, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Time projection chamber, 010308 nuclear & particles physics, Scattering, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), 3. Good health, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], chemistry, Weakly interacting massive particles, Atomic physics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The XENON100 dark matter experiment uses liquid xenon in a time projection chamber (TPC) to measure xenon nuclear recoils resulting from the scattering of dark matter Weakly Interacting Massive Particles (WIMPs). In this paper, we report the observation of single-electron charge signals which are not related to WIMP interactions. These signals, which show the excellent sensitivity of the detector to small charge signals, are explained as being due to the photoionization of impurities in the liquid xenon and of the metal components inside the TPC. They are used as a unique calibration source to characterize the detector. We explain how we can infer crucial parameters for the XENON100 experiment: the secondary-scintillation gain, the extraction yield from the liquid to the gas phase and the electron drift velocity., Comment: 16 pages, 8 figures. Accepted for publication in Journal of Physics G: Nuclear and Particle Physics

Published
2014
Full Text
View/download PDF

28. Conceptual design and simulation of a water Cherenkov muon veto for the XENON1T experiment

Author

Y. Meng, M. Murra, N. Priel, Jean-Pierre Cussonneau, M. Messina, Florian Kaether, M. Selvi, K. Arisaka, Gian Carlo Trinchero, Eilam Gross, A. Rizzo, A. Behrens, C. Reuter, S. Schindler, Luke Goetzke, S. E. A. Orrigo, J. A. M. Lopes, J. Naganoma, Auke-Pieter Colijn, A. Kish, D. Mayani Paras, Gabriella Sartorelli, A. Lyashenko, R. Persiani, S. Reichard, A. Molinario, L. Levinson, B. Miguez, F. Arneodo, P. Barrow, Giacomo Bruno, F. V. Massoli, A. Teymourian, S. Fattori, W. Hampel, Amos Breskin, Boris Bauermeister, R. F. Lang, E. Pantic, K. Bokeloh, D. Lellouch, Ethan Brown, João Cardoso, L. Scotto Lavina, W. Fulgione, J. Schreiner, M. Weber, S. MacMullin, M. P. Decowski, Manfred Lindner, Ran Budnik, A. D. Ferella, G. Kessler, K. Lung, D. Thers, G. Plante, A. Tiseni, Hongwei Wang, C. Grignon, F. Piastra, J.M.F. dos Santos, Marc Schumann, P. Shagin, Julien Masbou, H. Simgen, J. Pienaar, F. Agostini, A. J. Melgarejo Fernandez, M. Auger, M. Alfonsi, P. Beltrame, S. Rosendahl, Sebastian Lindemann, C. Balan, G. Morana, Elena Aprile, T. Marrodán Undagoitia, Ch. Weinheimer, Uwe Oberlack, April S. Brown, R. Itay, M. Garbini, E. Duchovni, Laura Baudis, M. Le Calloch, S. Bruenner, C. Levy, O. Vitells, C. Geis, H. Contreras, H. Landsman, E. Aprile, F. Agostini, M. Alfonsi, K. Arisaka, F. Arneodo, M. Auger, C. Balan, P. Barrow, L. Baudi, B. Bauermeister, A. Behren, P. Beltrame, K. Bokeloh, A. Breskin, A. Brown, E. Brown, S. Bruenner, G. Bruno, R. Budnik, J.M.R. Cardoso, A.P. Colijn, H. Contrera, J.P. Cussonneau, M.P. Decowski, E. Duchovni, S. Fattori, A.D. Ferella, W. Fulgione, M. Garbini, C. Gei, L.W. Goetzke, C. Grignon, E. Gro, W. Hampel, R. Itay, F. Kaether, G. Kessler, A. Kish, H. Landsman, R.F. Lang, M. Le Calloch, D. Lellouch, L. Levinson, C. Levy, S. Lindemann, M. Lindner, J.A.M. Lope, K. Lung, A. Lyashenko, S. MacMullin, T. Marrodán Undagoitia, J. Masbou, F.V. Massoli, D. Mayani Para, A.J. Melgarejo Fernandez, Y. Meng, M. Messina, B. Miguez, A. Molinario, G. Morana, M. Murra, J. Naganoma, U. Oberlack, S.E.A. Orrigo, E. Pantic, R. Persiani, F. Piastra, J. Pienaar, G. Plante, N. Priel, S. Reichard, C. Reuter, A. Rizzo, S. Rosendahl, J.M.F. dos Santo, G. Sartorelli, S. Schindler, J. Schreiner, M. Schumann, L. Scotto Lavina, M. Selvi, P. Shagin, H. Simgen, A. Teymourian, D. Ther, A. Tiseni, G. Trinchero, O. Vitell, H. Wang, M. Weber, C. Weinheimer, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), XENON100, Gravitation and Astroparticle Physics Amsterdam, IHEF (IoP, FNWI), IoP (FNWI), Faculty of Science, Other Research IHEF (IoP, FNWI), GRAPPA (ITFA, IoP, FNWI), and The XENON100 Collabration

Subjects
axions, Physics - Instrumentation and Detectors, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Cherenkov and transition radiation, Cherenkov detector, Physics::Instrumentation and Detectors, Dark matter, Detector modelling and simulations I (interaction of radiation with matter, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, law.invention, Nuclear physics, Xenon, WIMP, law, Cherenkov and transition radiation, Detector modelling and simulations, Cherenkov detectors, Dark Matter detectors, etc.), 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Dark Matter detectors (WIMPs, Mathematical Physics, Cherenkov radiation, etc), Physics, Muon, Time projection chamber, 010308 nuclear & particles physics, Cherenkov detectors, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, interaction of photons with matter, Instrumentation and Detectors (physics.ins-det), Dark Matter detectors (WIMPs, axions, etc.), interaction of hadrons with matter, etc), [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], interaction of hadrons with matter, chemistry, High Energy Physics::Experiment, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

XENON is a direct detection dark matter project, consisting of a time projection chamber (TPC) that uses xenon in double phase as a sensitive detection medium. XENON100, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, is one of the most sensitive experiments of its field. During the operation of XENON100, the design and construction of the next generation detector (of ton-scale mass) of the XENON project, XENON1T, is taking place. XENON1T is being installed at LNGS as well. It has the goal to reduce the background by two orders of magnitude compared to XENON100, aiming at a sensitivity of $2 \cdot 10^{-47} \mathrm{cm}^{\mathrm{2}}$ for a WIMP mass of 50 GeV/c$^{2}$. With this goal, an active system that is able to tag muons and their induced backgrounds is crucial. This active system will consist of a water Cherenkov detector realized with a water volume $\sim$10 m high and $\sim$10 m in diameter, equipped with photomultipliers of 8 inches diameter and a reflective foil. In this paper we present the design and optimization study for this muon veto water Cherenkov detector, which has been carried out with a series of Monte Carlo simulations, based on the GEANT4 toolkit. This study showed the possibility to reach very high detection efficiencies in tagging the passage of both the muon and the shower of secondary particles coming from the interaction of the muon in the rock: >99.5% for the former type of events (which represent $\sim$ 1/3 of all the cases) and >70% for the latter type of events (which represent $\sim$ 2/3 of all the cases). In view of the upgrade of XENON1T, that will aim to an improvement in sensitivity of one order of magnitude with a rather easy doubling of the xenon mass, the results of this study have been verified in the upgraded geometry, obtaining the same conclusions.

Published
2014
Full Text
View/download PDF

29. Erratum: Study of the electromagnetic background in the XENON100 experiment [Phys. Rev. D 83, 082001 (2011)]

Author

Hui Wang, K. Arisaka, E. Tziaferi, A. Behrens, Qing Lin, S. Fattori, Y. Mei, A. Askin, João Cardoso, A. C. C. Ribeiro, M. Weber, K. Lung, A. Teymourian, J.M.F. dos Santos, C. W. Lam, Ethan Brown, Hardy Simgen, A. D. Ferella, R.F. Lang, K. E. Lim, P. Shagin, K. Bokeloh, Sebastian Lindemann, J. A. M. Lopes, A. Kish, T. Marrodán Undagoitia, Karl Giboni, Laura Baudis, Uwe Oberlack, C. Weinheimer, David B. Cline, E. Pantic, Manfred Lindner, J. Lamblin, Kaixuan Ni, R. Santorelli, F. Arneodo, Guillaume Plante, S. E. A. Orrigo, A. J. Melgarejo Fernandez, Marc Schumann, B. Choi, D. Thers, and Elena Aprile

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Dark matter, Particle detector
Published
2012

30. Characterization of the Hamamatsu R11410-10 3-Inch Photomultiplier Tube for Liquid Xenon Dark Matter Direct Detection Experiments

Author

A. Bargetzi, A. Teymourian, P. Beltrame, T. Genma, A. Cahill, K. Arisaka, C. Ghag, J. Sainz, Y. Yoshizawa, K. Lung, and Daniel Gordon

Subjects
Nuclear and High Energy Physics, Photomultiplier, Physics - Instrumentation and Detectors, Dark matter, Phase (waves), chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, Noise (electronics), High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Optics, Xenon, 0103 physical sciences, 010306 general physics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astroparticle physics, Physics, 010308 nuclear & particles physics, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), 3. Good health, Characterization (materials science), chemistry, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract

To satisfy the requirements of the next generation of dark matter detectors based on the dual phase TPC, Hamamatsu, in close collaboration with UCLA, has developed the R11410-10 photomultipler tube. In this work, we present the detailed tests performed on this device. High QE (>30%) accompanied by a low dark count rate (50 Hz at 0.3 PE) and high gain (10^7) with good single PE resolution have been observed. A comprehensive screening measurement campaign is ongoing while the manufacturer quotes a radioactivity of 20 mBq/PMT. These characteristics show the R11410-10 to be particularly suitable for the forthcoming zero background liquid xenon detectors., 19 pages, 18 figures

Published
2012
Full Text
View/download PDF

31. Study of the electromagnetic background in the XENON100 experiment

Author

Ethan Brown, R. Santorelli, A. Askin, S. Fattori, João Cardoso, F. Arneodo, E. Pantic, S. E. A. Orrigo, J. Lamblin, Marc Schumann, P. Shagin, K. Arisaka, Hardy Simgen, A. D. Ferella, Y. Mei, A. C. C. Ribeiro, Kaixuan Ni, E. Tziaferi, Laura Baudis, D. Thers, Manfred Lindner, Hongwei Wang, R. F. Lang, A. J. Melgarejo Fernandez, David B. Cline, J. A. M. Lopes, K. E. Lim, A. Kish, Qing Lin, B. Choi, J.M.F. dos Santos, K. Bokeloh, Sebastian Lindemann, Elena Aprile, T. Marrodán Undagoitia, Ch. Weinheimer, K. L. Giboni, C. W. Lam, Uwe Oberlack, K. Lung, M. Weber, G. Plante, A. Teymourian, A. Behrens, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and XENON100

Subjects
Nuclear and High Energy Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Physics::Instrumentation and Detectors, Monte Carlo method, Dark matter, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, 7. Clean energy, Particle detector, Nuclear physics, Xenon, Recoil, 0103 physical sciences, 010306 general physics, Nuclear Experiment, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Elastic scattering, 010308 nuclear & particles physics, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], chemistry, High Energy Physics::Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Radioactive decay, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The XENON100 experiment, located at the Laboratori Nazionali del Gran Sasso (LNGS), aims to directly detect dark matter in the form of Weakly Interacting Massive Particles (WIMPs) via their elastic scattering off xenon nuclei. We present a comprehensive study of the predicted electronic recoil background coming from radioactive decays inside the detector and shield materials, and intrinsic contamination. Based on GEANT4 Monte Carlo simulations using a detailed geometry together with the measured radioactivity of all detector components, we predict an electronic recoil background in the WIMP-search energy range (0-100 keV) in the 30 kg fiducial mass of less than 10e-2 events/(kg-day-keV), consistent with the experiment's design goal. The predicted background spectrum is in very good agreement with the data taken during the commissioning of the detector, in Fall 2009., 10 pages, 12 figures The updated version of the paper takes into account the new measurement of $^{136}$Xe 2$\nu$ $\beta\beta$ decay by EXO-200, with a half-life of (2.11$\pm0.04\pm$0.021)$\times10^{21}$ years

Published
2011

32. Characterization of the QUartz Photon Intensifying Detector (QUPID) for Noble Liquid Detectors

Author

David B. Cline, Shinichi Muramatsu, Ethan Brown, C. W. Lam, T. Lim, Motohiro Suyama, Laura Baudis, K. Arisaka, Daniel Aharoni, E. Pantic, P. Beltrame, A. D. Ferella, Y. Meng, K. Lung, Atsuhito Fukasawa, Hui Wang, A. Teymourian, University of Zurich, and Teymourian, A

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, 530 Physics, Photodetector, chemistry.chemical_element, FOS: Physical sciences, 10192 Physics Institute, 01 natural sciences, 7. Clean energy, Photocathode, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Optics, Xenon, 0103 physical sciences, 3106 Nuclear and High Energy Physics, 010306 general physics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Scintillation, 010308 nuclear & particles physics, business.industry, 3105 Instrumentation, Detector, Instrumentation and Detectors (physics.ins-det), Avalanche photodiode, Photon counting, 3. Good health, chemistry, 13. Climate action, Quantum efficiency, business, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Dark Matter and Double Beta Decay experiments require extremely low radioactivity within the detector materials. For this purpose, the University of California, Los Angeles and Hamamatsu Photonics have developed the QUartz Photon Intensifying Detector (QUPID), an ultra-low background photodetector based on the Hybrid Avalanche Photo Diode (HAPD) and entirely made of ultraclean synthetic fused silica. In this work we present the basic concept of the QUPID and the testing measurements on QUPIDs from the first production line. Screening of radioactivity at the Gator facility in the Laboratori Nazionali del Gran Sasso has shown that the QUPIDs safely fulfill the low radioactive contamination requirements for the next generation zero background experiments set by Monte Carlo simulations. The quantum efficiency of the QUPID at room temperature is > 30% at the xenon scintillation wavelength. At low temperatures, the QUPID shows a leakage current less than 1 nA and a global gain of 10^5. In these conditions, the photocathode and the anode show > 95% linearity up to 1 uA for the cathode and 3 mA for the anode. The photocathode and collection efficiency are uniform to 80% over the entire surface. In parallel with single photon counting capabilities, the QUPIDs have a good timing response: 1.8 +/- 0.1 ns rise time, 2.5 +/- 0.2 ns fall time, 4.20 +/- 0.05 ns pulse width, and 160 +/- 30 ps transit time spread. The QUPIDs have also been tested in a liquid xenon environment, and scintillation light from 57Co and 210Po radioactive sources were observed., 15 pages, 22 figures

Published
2011
Full Text
View/download PDF

33. Role of KLF2 in endocardial cushion development in mice

Author

Joyce A. Lloyd, Tina K. Lung, Aditi R. Chiplunkar, and Jack L. Haar

Subjects
business.industry, Genetics, Medicine, Anatomy, Atrioventricular cushions, business, Molecular Biology, Biochemistry, Biotechnology
Published
2010

34. Role of KLF2 in atrioventricular cushion development

Author

Joyce A. Lloyd, Jack L. Haar, Tina K. Lung, and Aditi R. Chiplunkar

Subjects
business.industry, Cushion, Genetics, Medicine, Anatomy, business, Molecular Biology, Biochemistry, Biotechnology
Published
2009

35. Erythropoietin-Induced Phosphorylation/Degradation of BIM Contributes to Survival of Erythroid Cells

Author

Stephen T. Sawyer, Joyce A. Lloyd, Jingchun Chen, Tina K. Lung, Randolph M. Abutin, and Hisashi Harada

Subjects
MAPK/ERK pathway, Cancer Research, Programmed cell death, Cell Survival, MAP Kinase Signaling System, cells, Apoptosis, Biology, Article, Cell Line, Small hairpin RNA, Mice, Erythroid Cells, hemic and lymphatic diseases, Proto-Oncogene Proteins, Genetics, medicine, Animals, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, neoplasms, Molecular Biology, Erythropoietin, Mice, Knockout, Bcl-2-Like Protein 11, Kinase, Membrane Proteins, hemic and immune systems, Cell Biology, Hematology, Cancer research, Proteasome inhibitor, biological phenomena, cell phenomena, and immunity, Apoptosis Regulatory Proteins, medicine.drug
Abstract

Objective A proapoptotic BH3-only protein BIM (BCL-2 interacting mediator of cell death) can link cytokine receptor signaling with the apoptotic machinery in hematopoietic cells. We investigated here the role of BIM in erythropoietin (EPO)-mediated survival in erythroid cells. Materials and Methods We downregulated BIM in EPO-dependent HCD57 erythroid cells with short hairpin RNA (shRNA), and used real-time polymerase chain reaction, Western blots, and flow cytometry to characterize BIM expression and apoptosis. Hematologic analyses of BIM-deficient ( Bim –/– ) mice were conducted. Results BIM expression increases in primary murine erythroid cells and HCD57 cells deprived of EPO. Whereas Bim mRNA increased less than twofold, BIM protein increased more than 10-fold after EPO withdrawal, suggesting posttranscriptional regulation of BIM. EPO treatment resulted in rapid phosphorylation of BIM at Serine 65 and phosphorylation correlated with degradation of BIM. Inhibition of extracellular signal-regulated kinase (ERK) by a MEK/ERK inhibitor, U0126, blocked both phosphorylation and degradation of BIM, resulting in apoptosis. Treatment with a proteasome inhibitor, MG-132, also blocked degradation of phosphorylated BIM. Downregulation of BIM with the shRNA resulted in HCD57 cells more resistant to apoptosis induced by either EPO withdrawal or ERK inhibition. Although we observed no significant changes in the number of erythrocytes or reticulocytes in the circulation of Bim –/– mice, erythroid progenitors from bone marrow in Bim –/– mice were reduced in number and more resistant to apoptosis induced by U0126 MEK/ERK inhibitor. Conclusion EPO protects erythroid cells from apoptosis in part through ERK-mediated phosphorylation followed by proteasomal degradation of BIM.

Published
2008

36. Dark matter results from 225 live days of XENON100 data

Author

W. Hampel, M. Garbini, J.M.F. dos Santos, J. Lamblin, K. Bokeloh, Jean-Pierre Cussonneau, S. Rosendahl, Ethan Brown, M. Selvi, Sebastian Lindemann, Eilam Gross, Boris Bauermeister, P. Beltrame, Jochen Schreiner, Luke Goetzke, Hardy Simgen, A. D. Ferella, G. Sartorelli, A. Teymourian, F. Arneodo, Laura Baudis, H. Landsman, M. Le Calloch, J. A. M. Lopes, S. Fattori, Y. Meng, O. Vitells, A. Rizzo, David B. Cline, S. E. A. Orrigo, A. Kish, João Cardoso, K. Arisaka, R. Persiani, L. Scotto Lavina, C. Grignon, K. L. Giboni, H. Contreras, F. Gao, A. Behrens, E. Pantic, C. Balan, D. Thers, Ehud Duchovni, W. T. Chen, K. E. Lim, M. Weber, Auke-Pieter Colijn, R. F. Lang, Uwe Oberlack, Elena Aprile, Kaixuan Ni, E. Nativ, T. Marrodán Undagoitia, G. Plante, B. Choi, Ch. Weinheimer, A. J. Melgarejo Fernandez, P. R. Scovell, C. Ghag, F. V. Massoli, Qing Lin, M. Alfonsi, K. Lung, A. Molinario, W. Fulgione, Giacomo Bruno, C. Levy, N. Priel, Hui Wang, Florian Kaether, M. P. Decowski, Manfred Lindner, Marc Schumann, P. Shagin, Ran Budnik, Astroparticle Physics (IHEF, IoP, FNWI), E. Aprile, M. Alfonsi, K. Arisaka, F. Arneodo, C. Balan, L. Baudi, B. Bauermeister, A. Behren, P. Beltrame, K. Bokeloh, E. Brown, G. Bruno, R. Budnik, J. M. R. Cardoso, W.-T. Chen, B. Choi, D. Cline, A. P. Colijn, H. Contrera, J. P. Cussonneau, M. P. Decowski, E. Duchovni, S. Fattori, A. D. Ferella, W. Fulgione, F. Gao, M. Garbini, C. Ghag, K.-L. Giboni, L. W. Goetzke, C. Grignon, E. Gro, W. Hampel, F. Kaether, A. Kish, J. Lamblin, H. Landsman, R. F. Lang, M. Le Calloch, C. Levy, K. E. Lim, Q. Lin, S. Lindemann, M. Lindner, J. A. M. Lope, K. Lung, T. Marrodán Undagoitia, F. V. Massoli, A. J. Melgarejo Fernandez, Y. Meng, A. Molinario, E. Nativ, K. Ni, U. Oberlack, S. E. A. Orrigo, E. Pantic, R. Persiani, G. Plante, N. Priel, A. Rizzo, S. Rosendahl, J. M. F. dos Santo, G. Sartorelli, J. Schreiner, M. Schumann, L. Scotto Lavina, P. R. Scovell, M. Selvi, P. Shagin, H. Simgen, A. Teymourian, D. Ther, O. Vitell, H. Wang, M. Weber, C. Weinheimer, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), and XENON100

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics - Instrumentation and Detectors, Large Underground Xenon experiment, Dark matter, FOS: Physical sciences, General Physics and Astronomy, WIMP Argon Programme, 01 natural sciences, 7. Clean energy, Particle detector, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), WIMP, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Liquid Xenon, Physics, Range (particle radiation), 010308 nuclear & particles physics, DARK MATTER, Instrumentation and Detectors (physics.ins-det), High Energy Physics - Phenomenology, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], DAMA/NaI, TPC, PandaX, Direct search for Dark Matter, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We report on a search for particle dark matter with the XENON100 experiment, operated at the Laboratori Nazionali del Gran Sasso (LNGS) for 13 months during 2011 and 2012. XENON100 features an ultra-low electromagnetic background of (5.3 \pm 0.6) \times 10^-3 events (kg day keVee)^-1 in the energy region of interest. A blind analysis of 224.6 live days \times 34 kg exposure has yielded no evidence for dark matter interactions. The two candidate events observed in the pre-defined nuclear recoil energy range of 6.6-30.5 keVnr are consistent with the background expectation of (1.0 \pm 0.2) events. A Profile Likelihood analysis using a 6.6-43.3 keVnr energy range sets the most stringent limit on the spin-independent elastic WIMP-nucleon scattering cross section for WIMP masses above 8 GeV/c^2, with a minimum of 2 \times 10^-45 cm^2 at 55 GeV/c^2 and 90% confidence level., 6 pages, 5 figures. Matches version accepted by PRL. Includes limits up to 10 TeV/c^2, published as supplementary material: http://prl.aps.org/supplemental/PRL/v109/i18/e181301 Please cite high mass limits as "Phys. Rev. Lett. 109, 181301 (2012), online supplementary material."

Published
2012

37. Survey on health status of heavy vehicle drivers in Klang valley

Author

P, Krishnan, N, Hashim, U, Rani, and J K, Lung

Subjects
Automobile Driving, Motor Vehicles, Health Status, Malaysia, Automobile Driver Examination, Humans, Health Surveys
Abstract

A survey was carried out using a medical examination format that was prepared by the Malaysian Medical Association. The findings of the survey show that of the 266 cases surveyed, 64 drivers (24% of cases surveyed) are either totally unfit to drive or temporarily unfit to drive heavy goods and passenger vehicles. This is clear indication that the current format that is being used by the Road Transport Department is inadequate and needs to be reviewed. It must also be stressed that all the above 64 drivers have been certified fit using the existing Road Transport Department format and are currently driving in our highways and roads. Heavy vehicle goods and passenger vehicle drivers if not properly examined and medically certified are not only be endangering their own lives but also that of others. It is therefore recommended that based on the data available from this survey, the Road Transport Department should seriously consider adopting the medical examination format that was formalised by the Malaysian Medical Association and used in this survey.

Published
2000

38. Pseudoaneurysm after high tibial osteotomy and limb lengthening

Author

T. K. Lung, James F. Griffith, Michael Chan, and Jack C. Y. Cheng

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Postoperative Hemorrhage, Osteotomy, Pseudoaneurysm, Cicatrix, Aneurysm, High tibial osteotomy, Bone Lengthening, medicine.artery, medicine, Humans, Orthopedics and Sports Medicine, Tibia, Embolization, Rupture, business.industry, General Medicine, medicine.disease, Embolization, Therapeutic, Surgery, Leg Length Inequality, Tibial Arteries, Tibial Fractures, Anterior tibial artery, Orthopedic surgery, Radiology, business, Femoral Fractures, Aneurysm, False, Follow-Up Studies
Abstract

A case of a young man with anterior tibial artery rupture and pseudoaneurysm formation that occurred during lengthening of a scarred limb is presented. Leg length discrepancy occurred because of previous distal femoral and proximal tibial fractures. Two corrective operations were performed 11 and 2 years earlier at another hospital. As limb deformity persisted, distal femoral and proximal tibial osteotomies combined with limb lengthening were performed. The aim was to achieve 120 mm (70 mm femoral, 50 mm tibial) lengthening. The operative and early postoperative course was uneventful. Twenty-six days after surgery (when femoral and tibial lengthening was 13.5 mm and 5.5 mm, respectively), blood began oozing from the operative scar during limb distraction. At 70 days after surgery (when femoral and tibia lengthening was 41.5 mm and 14 mm, respectively), a rupture and pseudoaneurysm of the anterior tibial artery became apparent. Documentation of a normal pulses in the foot after surgery, the late presentation of pseudoaneurysm, and the initiation of bleeding by limb distraction indicate that limb lengthening either aggravated an unrecognized arterial injury or precipitated de novo rupture of the anterior tibial artery scarred from previous trauma. The pseudoaneurysm was treated successfully by transarterial embolization.

Published
1998

39. SAT0435 A1G T-Type Calcium Channel is Expressed in Human Fetal Hearts and Has an Extracellular Epitope Bound by Autoantibodies from Congenital Heart Block Maternal Sera

Author

Charles M. Deber, J. Y. Yan, X. Liu, M. Capecchi, Linn S. Strandberg, Arianna Rath, Earl D. Silverman, Edgar Jaeggi, L. Biavati, Robert M. Hamilton, Vinayakumar Siragam, W. Yuen, A. Accorroni, Xuezhi Cui, Filippo Quattrone, B. B. Su, K. Lung, and Cameron Ackerley

Subjects
Fetus, biology, medicine.diagnostic_test, business.industry, Immunology, Autoantibody, Immunofluorescence, General Biochemistry, Genetics and Molecular Biology, Epitope, Andrology, Rheumatology, Western blot, CACNA1H, biology.protein, medicine, Extracellular, Immunology and Allergy, Antibody, business
Abstract

Background Background: Congenital heart block (CHB) is a transplacentally acquired autoimmune disease associated with anti-Ro/La maternal autoantibodies and is characterized primarily by atrioventricular (AV) block of the fetal heart. Since the Ro/La autoantigens are intracellular proteins, they are not likely the targets of these maternal autoantibodies and likely cross-react with other proteins on the surface of cardiomyocytes. Objectives Objectives: This study aims to investigate whether the α 1G T-type calcium channel is expressed in human fetal hearts, and if maternal serum antibodies from CHB affected pregnancies bind to the α 1G T-type calcium channel subunit in human fetal hearts. Methods Methods: Expression of α 1G was demonstratedin human fetal hearts by RT-PCR, and by Western Blot analysis of human fetal heart lysates. Immunological methods such as Western blot, ELISA, immunofluorescence and flow cytometry were utilized to demonstrate the binding of antibodies in serum from CHB affected pregnancies to the α 1G protein on the surface of human fetal cardiomyocytes. Results Results: We demonstrate differential mRNA expression of CACNA1G (α 1G gene) and CACNA1H (α 1H gene) in the AV junction of human fetal hearts compared to the apex (18-22.6 weeks gestation). Immunoprecipitation and Western blot analysis of α 1G from human fetal hearts (20-22 wks gestation) demonstrates reactivity of maternal serum from CHB affected pregnancies but not from controls. Immunofluorescence (IF) staining and flow cytometry analysis also demonstrates expression of T-type Ca 2+ channel subunits in cardiomyocytes from 20-22 week old human fetal hearts. ELISA was used to assay the reactivity of sera from mothers with pregnancies affected by CHB and from controls to a series of peptides derived from the amino acid sequences of extracellular regions of α 1G . Antibody reactivity to a peptide designated as p305 [corresponding to aa305-319 of the extracellular loop linking transmembrane segments S5-S6 in α 1G repeat I], was significantly higher in the CHB maternal sera compared to controls (p 1H by all CHB sera that were reactive to the α 1G peptide (7/15 amino acids conserved). Conclusions Conclusions: These results taken together indicate that α 1G and possibly α 1H are bound in extracellular regions by autoantibodies found in CHB maternal serum. Autoantibodies involved in CHB may thus cross-react and bind several fetal targets. Disclosure of Interest None Declared

Published
2013

40. Early secondary alveolar bone grafts

Author

K. Lung, David S. Precious, and C.G. Robertson

Subjects
Pathology, medicine.medical_specialty, Otorhinolaryngology, business.industry, Medicine, Surgery, Bone healing, Oral Surgery, business, Dental alveolus
Published
2003

41. Flame initiation in lean, quiescent and turbulent mixtures with various igniters

Author

P.M. Boston, I.M. Vince, D. Bradley, F.J. Weinberg, and F.K-K. Lung

Subjects
Premixed flame, Torch, Laminar flame speed, Chemistry, Turbulence, Diffusion flame, Analytical chemistry, Mechanics, Flame speed, law.invention, Physics::Fluid Dynamics, Ignition system, Volume (thermodynamics), Physics::Plasma Physics, law, Physics::Chemical Physics
Abstract

High speed flame photographs have been taken, following ignition, in an explosion bomb, equipped with four high speed fans to create turbulence. The different igniters studied, under quiescent and turbulent conditions of the the lean methane-air mixture, comprised o (i) a conventional two electrode spark system (ii) a surface discarge spark (iii) a plasma jet (iv) a plasma jet with wetted cavity (v) a torch from a pre-chamber Hot kernel volume, flame front wrinkling and flame speed were measured during the early stages of flame development. Systems (ii) to (v) were potentially superior to (i) in their ability to create a larger igniting volume of hot, reactive gas. The flame speeds for systems (iii) to (v) were enhanced by jet-generated turbulence and, additionally, by active species in the case of the plasma jet. In turbulent mixtures, after a few milliseconds the flame speed is predominantly a function of the turbulence. Ignition limits have been measured over a range of r.m.s. turbulent velocities and different igniters compared. With limit mixtures, the ratio of chemical to eddy lifetime is a useful correlating parameter. Ignition limits for the different igniters fall within an upper bound for flame propagation defined by a fixed value of this ratio.

Published
1985

42. Combustion regimes and the straining of turbulent premixed flames

Author

F.K.-K. Lung, R.G. Abdel-Gayed, and Derek Bradley

Subjects
Fuel Technology, Materials science, Turbulence, General Chemical Engineering, General Physics and Astronomy, Energy Engineering and Power Technology, General Chemistry, Mechanics, Combustion
Published
1989

43. Internal and Atmospheric Leakage Assessment and Intergate Overpressurization of Isolation Valves

Author

D R Airey, F K K Lung, S Salter, and M J Metcalf

Subjects
Leak, Materials science, business.industry, General Engineering, Isolation valve, Mechanics, Structural engineering, Cracking, Bellows, Cavitation, Friction reduction, Stress corrosion cracking, business, human activities, Leakage (electronics)
Abstract

Some problem areas which would lead to internal and atmospheric leakage in valves, specifically for pressurized water reactors, are identified. Frequent thermal transients can induce thermal stresses and promote the propagation of surface faults into the valve body and cause eventual cracking of the seat. Trapping of hard debris around the seat causes seat and disc damage as well as providing leak paths. Cavitation can also produce seat and disc damage, particularly in high-speed flows. Atmospheric leakage is caused mainly by the deficiencies in gland packings and by overpressurization problems in valves. In the case of bellows and diaphragm sealed valves, metal fatigue, stress corrosion cracking and punctures are the usual cause. The overpressurization problem in valves can increase the rate of gland deterioration. The problem is discussed in some detail in this paper. Analysis of theoretical gland packing results suggest that stem friction reduction and discarding lantern rings in stuffing boxes can improve the sealing performance of the packings. Ideally the sealing material should have a low coefficient of friction and a high Poisson ratio.

Published
1988

44. Spark ignition and the early stages of turbulent flame propagation

Author

F.K-K. Lung and Derek Bradley

Subjects
Shock wave, Explosive material, Wave propagation, Turbulence, Chemistry, General Chemical Engineering, General Physics and Astronomy, Energy Engineering and Power Technology, General Chemistry, Mechanics, law.invention, Ignition system, Minimum ignition energy, Fuel Technology, Physics::Plasma Physics, law, Spark (mathematics), Fluid dynamics, Physics::Chemical Physics
Abstract

A hydrodynamic mathematical model is presented, without chemical kinetics, for the ignition of gaseous mixtures. Solution schemes are discussed and computed results presented for the initial shock wave propagation and the slower spreading of the thermal wave from the narrow spark discharge channel. Different spark power-time profiles are analyzed and it is clear that a central problem is the slow spread of energy from the discharge channel to ignite a critical volume. An initial high energy input aids this process. Ignition delay times are presented, based upon thermal ignition criteria. Minimum ignition energy is increased for turbulent mixtures because of the effects of flame straining. Ignition experiments are reported for a fan-stirred bomb. Spark power profiles and turbulent velocities were controlled and CH emission intensities measured. Ignition and flame development were traced from high speed schieren photographs. Three regimes are delineated: localized ignition, spark assisted flame propagation, and normal propagation.

Published
1987

45. Rhodium(II) complexes as hydrosilylation and hydrogenation catalysts

Author

Terence A. Nile, J.P. Howe, and K. Lung

Subjects
Inorganic Chemistry, chemistry.chemical_compound, chemistry, Hydrosilylation, Organic Chemistry, Materials Chemistry, chemistry.chemical_element, Organic chemistry, Physical and Theoretical Chemistry, Biochemistry, Rhodium, Catalysis
Abstract

Two phosphine-rhodium(II) complexes, bis(tris-o-tolylphosphine)dichlororhodium(II) and bis(tricyclohexyl-phosphine)dichlororhodium(II), have been found to be active catalysts for the hydrosilylation of a variety of organic substrates, and, in conjunction with triethylaluminum, to be hydrogenation catalysts.

Published
1981

46. On Müntz-Jackson's theorem

Author

K. Lung and P. Szüsz

Subjects
Combinatorics, Factor theorem, Fundamental theorem, General Mathematics, Compactness theorem, Danskin's theorem, Brouwer fixed-point theorem, Muntz metal, Squeeze theorem, Mathematics, Carlson's theorem
Published
1973

48. A One Dimensional Quasi-Steady Model for Prediction of Safety Valve Lift Characteristics

Author

F. K. K. Lung

Subjects
Subcooling, Materials science, Back pressure, Lift (data mining), Mass flow, Quasi steady, Mass flow rate, Mechanics, Boiler blowdown, Safety valve
Abstract

A one dimensional quasi-steady model is presented for predicting spring loaded safety valve characteristics. To extend the applicability of the model to two-phase and subcooled water operation, the thermodynamic properties are determined from steam tables directly. Based on the information published in the literature, valve characteristics for a 6 inch spring loaded safety relief are constructed. Numerical experiments are carried out to study the valve behaviour under different operating conditions. The effects of pressure ramps and ring settings on the mass flow rates, percentage blowdown and reseat pressure are discussed in some detail. Design parameters such as the maximum amount of lift allowed, seat area and back pressure on the valve disc are shown to be important for satisfactory valve performance.

Published
1988

Catalog

Books, media, physical & digital resources
See catalog results