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1. OP0109 EXPRESSION QUANTITATIVE TRAIT LOCI IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS

Author: K. Goldmann, E. Vigorito, C. Wallace, M. Barnes, A. Barton, C. Pitzalis, and M. Lewis
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundTo date more than 100 genetic loci have been associated with rheumatoid arthritis (RA), particularly in the human leukocyte antigen (HLA) region. Our understanding of the functional consequences of genetic variation in RA causality, however, is limited and it has been shown that a substantial portion of complex disease risk alleles modify gene expression in a cell-specific manner [1]. The Pathobiology of Early Arthritis Cohort (PEAC) is a longitudinal study looking at treatment-naiv̈e RA patients with genotyped data as well as both synovial and blood RNA-sequenced biopsies prior to treatment with disease modifying anti-rheumatic drugs (DMARDs).ObjectivesTo explore expression quantitative trait loci (eQTL) in synovium and blood within PEAC and characterise the effects of genetic variation on gene expression measured by RNA-sequencing. A further goal was to investigate the role of these variants in RA disease severity and response variables.MethodsGenotypes were generated by Illumina Human CoreExome-24 version 1-0 array in 118 RA patients. Single nucleotide polymorphisms (SNPs) in the HLA region were imputed using HLA-TAPAS. A candidate gene study was performed on variants within the HLA region using Plink v2.0. Synovial (n=85) and blood (n=51) RNA-sequenced samples then underwent cis-eQTL analysis (loci within ±5x105Mb of the variant) based on linear regression models with the matrixeQTL R package using PEER [2] and PCA eigenvectors as covariates. Differences in eQTL between tissues were determined using a linear interaction term.ResultsThe candidate gene study determined several amino acids around HLA-DRB1 acting as markers for seropositivity, which replicated findings by Raychaudhuri et. al. [3]. Using eQTL analysis, around 33,000 synovial SNPs were found with genome-wide significance (p ≤ 5x10-8) and around 29,000 in blood. This corresponded to 279 unique significant genes in synovium and 417 in blood (Figure 1). There were 100 genes common to both synovium and blood, including PSORS1C3, HLA-DRB9 and ERAP2, which have known associations with autoimmune diseases and inflammatory arthritis. Notably, 92 genes showed significantly different patterns of QTL expression between synovial tissue and blood (p ≤ 5x10-8). eQTL data also confirmed the triad of genetic variants significantly driving tissue gene expression of HLA-DPB2, while both HLA-DPB2 SNPs and HLA-DPB2 RNA-sequencing synovial expression correlated highly with erythrocyte sedimentation rate (ESR).Figure 1.Manhattan plots for cis-expression quantitative trait loci (eQTL) analysis performed on 85 synovial samples (top) and 51 blood samples (middle). Tissue interaction eQTL (bottom) show significant differences between tissues (p ≤ 5x10-8).ConclusionThe high significance of genes in the HLA region in both tissues is in-keeping with the strong association between HLA and susceptibility to RA, as well as other autoimmune diseases. Most notably variants linked to HLA-DPB2 synovial expression were found to be a marker for disease severity through ESR association. Additionally, the significant differences between eQTL in blood and synovium highlight the need to explore functional consequences of genetic associations in the diseased tissue directly.References[1]Thalayasingam et. al. (2018). CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in patients with untreated early arthritis: implications for causal gene identification. Arthritis & Rheumatology, 70(3), 361-370.[2]Stegle et al. (2012). Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses. Nature protocols, 7(3), 500-507.[3]Raychaudhuri et al. (2012). Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nature genetics, 44(3), 291-296.Disclosure of InterestsNone declared
Published: 2022
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2. Primäre intakte omentale Bauchhöhlenschwangerschaft – ein seltenes Ereignis

Author: K Goldmann, S Grüßner, A Gabsi, M El-Sendiony, B Holmer, G Fischer, and M Schmitt
Published: 2020
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3. POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME

Author: E. Pontarini, F. Chowdhury, E. Sciacca, S. Grigoriadou, W. Murray-Brown, F. Rivellese, D. Lucchesi, K. Goldmann, L. Fossati-Jimack, E. Jaworska, G. M. Ghirardi, A. Nerviani, P. Emery, W. F. Ng, N. Sutcliffe, A. Tappuni, M. Lewis, S. Arends, L. De Wolff, H. Bootsma, C. Pitzalis, S. J. Bowman, and M. Bombardieri
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundThe TRial for Anti-B-Cell Therapy In patients with pSS (TRACTISS) is the largest multi-centre, placebo-controlled, phase-III trial with the administration of 2 cycles of Rituximab (RTX) or placebo at week 0 and 24, with trial clinical endpoints at week 48. Despite the primary endpoints (30% reduction in fatigue or oral dryness) were not met, RTX treated patients showed an improvement in secondary endpoints, such as unstimulated whole salivary flow (UWSF), and salivary gland (SG) total ultrasound score1,2. Additionally, recent post-hoc analysis of TRACTISS using novel CRESS composite endpoints3, highlighted a significantly increased response rate in the RTX vs placebo arm.ObjectivesTo perform the first longitudinal analysis of matched transcriptomic and histological data of SG biopsies of pSS patients treated with RTX vs placebo at 3 time points, over 48 weeks, from the TRACTISS cohort, in order to identify mechanisms of response/resistance to B cell depletion.Methods29 pSS patients randomised to RTX or placebo arm consented for labial SG biopsies at week 0, 16 and 48. Patients received two 1000mg cycles of RTX or placebo at week 0 and 24. SG focus score, inflammatory aggregate area fraction, B-cells (CD20+), T-cells (CD3+), follicular dendritic cells (FDCs) (CD21+) and plasma cells (CD138+) density were assessed using quantitative digital image analysis. RNA sequencing with deconvolution and pathway analysis was performed to identify genes signatures and consensus gene modules as biomarkers of disease evolution and response/resistance to therapy.ResultsPlacebo-treated SGs showed worsening of SG inflammation highlighted by the increment of aggregate size, B-cell density, development of new FDC networks, and a higher ectopic GC prevalence over 48 weeks, compared to RTX-treated patients. No difference in focus score, total T-cell and plasma cell infiltration was observed. RTX downregulated genes involved in immune cell recruitment and inflammatory aggregate organisation (e.g. CXCL13, CCR7 and PDCD1). Gene signature-based analysis of 35 immune cell types using XCell highlighted how RTX blocked class-switched and memory-B-cells accumulation in SGs over 48 weeks. Pathway analyses confirmed the downregulation of leukocyte migration, MHC-II antigen presentation, and T-cell co-stimulation immunological pathways, such as the CD40 receptor complex pathway. Among RTX-treated patients, only CRESS-responders demonstrated prevention of worsening B cell-driven molecular pathology signatures over time and a significant improvement in UWSF, in parallel with the upregulation of molecular pathways associated to SG restoration of the glandular epithelium. None of the above effects were observed at week 16 after the first RTX cycle.ConclusionTwo RTX infusions repeated at week 24 exerted beneficial effects on labial SG inflammatory infiltration in pSS by downregulating genes involved in immune cell recruitment, activation and organisation in ectopic GCs. Conversely, all the above parameters showed significant evolution in placebo treated patients over 48 weeks demonstrating progression of SG immunopathology. Clinical responders to RTX based on CRESS response criteria were characterised by preservation of exocrine function which appear driven by SG epithelial restoration.References[1]Fisher, B. A. et al. Effect of rituximab on a salivary gland ultrasound score in primary Sjögren’s syndrome: results of the TRACTISS randomised double-blind multicentre substudy. Ann. Rheum. Dis.77, 412–416 (2018).[2]Bowman, S. J. et al. Randomized Controlled Trial of Rituximab and Cost-Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren’s Syndrome. Arthritis Rheumatol.69, 1440–1450 (2017).[3]Arends, S. et al. Composite of Relevant Endpoints for Sjögren’s Syndrome (CRESS): development and validation of a novel outcome measure. Lancet Rheumatol.3, e553–e562 (2021).Disclosure of InterestsNone declared
Published: 2022
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4. POS0441 IN-DEPTH ANALYSIS OF Axl AND MerTK EXPRESSION PATTERNS AND REGULATION BY BIOLOGIC TREATMENTS IN RHEUMATOID ARTHRITIS

Author: A. Nerviani, M. A. Boutet, G. M. Ghirardi, K. Goldmann, E. Sciacca, F. Rivellese, E. Pontarini, M. Caliste, E. Prediletto, M. Bombardieri, M. Lewis, and C. Pitzalis
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundTyrosine kinases receptors MerTK and Axl have been implicated in the pathogenesis of several autoimmune diseases. Despite sharing significant structural homology and having common ligands, Axl and MerTK have distinct features and biological functions [1]. A growing body of evidence suggests that both Axl and MerTK play a crucial role in Rheumatoid Arthritis (RA) pathogenesis and progression and may be exploited as novel therapeutic targets [2]. However, numerous unanswered questions remain to be addressed.Objectives:i.To define common and distinct gene-partners of Axl/MerTK and quantify their expression in RA synovial tissue.ii.To assess the co-expression of Axl/MerTK by synovial cells.iii.To outline the longitudinal variation in Axl/MerTK expression upon treatment intervention.MethodsSynovial tissue samples were collected by US-guided synovial biopsy from: i. Patients with early (ResultsUsing STRING network analysis, we defined an Axl- and a MerTK-module composed of 31 predicted gene-partners of either Axl or MerTK. Thirteen genes were common to both modules and included the ligands Gas6 and ProteinS, and EGFR. Conversely, eighteen genes were uniquely present in the Axl-module (e.g., PIK3-family, IGF1R, IFNAR1 and STAT3) or the MerTK-module (e.g., Galectin3 and TULP, recently discovered MerTK ligands, FCGR1A/CD64, PTPN1and MEGF10). Axl/MerTK-modules quantified in the early-arthritis treatment-naïve RNAseq dataset showed a significant negative correlation with the synovitis score (Axl r=−0.33, p=0.0032; MerTK r=-0.33, p=0.003). At protein level, CD68+macrophages of the Lining showed notable heterogeneity between patients: they could express either Axl or MerTK alone, or co-express both. Axl was also present in most CD55+ Lining Fibroblast-Like-Cells (FLS) but not by CD90+ Sublining FLS while MerTK, as expected, was restricted to macrophages, including intra-aggregate tingible-body-macrophages.To define how Axl and MerTK vary depending on disease stage and treatment exposure, we quantified their gene expression in active RA patients inadequately responding to TNFi, prior and 16 weeks after starting second-line biologic (RTX or TOC) [3]. Differently from the early-arthritis cohort, MerTK was significantly up-regulated in synovia characterised by higher degree of tissue inflammation (lympho-myeloid > diffuse-myeloid > pauci-immune, pConclusionOur data further corroborate that Axl and MerTK constitute a dynamic axis influenced by the synovial tissue inflammatory features, the disease stage, the exposure and the response to targeted treatment and the blockade of critical inflammatory pathways over time. A better understanding of the individual features of these tyrosine kinases as well as their interaction would be beneficial to define novel treatment approaches.References[1]Zagórska A, et al. Nat Immunol. 2014 Oct;15(10):920-8[2]Kemble S, Croft AP. Front Immunol. 2021 Sep 3;12:715894[3]Humby F et al. Lancet. 2021 Jan 23;397(10271):305-317AcknowledgementsVersus Arthritis.Disclosure of InterestsNone declared.
Published: 2022
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5. OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS

Author: A. Surace, E. Sciacca, K. Goldmann, F. Rivellese, C. Cubuk, G. Giorli, L. Fossati-Jimack, M. Ahmed, E. Prediletto, M. Bombardieri, M. Lewis, and C. Pitzalis
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundAlthough up to 5-20% of rheumatoid arthritis (RA) patients do not respond to all current medications including biologic therapies, relatively little is known about the underlying pathogenic mechanisms driving non-response. In the first biopsy-driven randomized clinical trial in RA (R4RA)1, patients, in whom synthetic-DMARDs and at least one anti-TNF drug were not effective, were randomised 1:1 to rituximab (RTX) or tocilizumab (TOC) with a balanced stratification based on their synovial B-cell rich/poor signature, and response was assessed at 16 weeks. Non-responders were subsequently allowed to switch to the alternative drug with 48-week follow-up.ObjectivesInvestigate mechanisms of response and non-response to RTX and TOC through deep molecular (RNA-Sequencing) profiling of synovial tissue.MethodsRNA-Seq from baseline synovial tissue biopsies of patients who received RTX (n=88) or TOC (n=94) at any point in the trial was analysed for differentially expressed genes and associated modules between responders and non-responders. Response was defined as 50% improvement in clinical disease activity index (CDAI) score. Patients who had received both drugs during the trial were subdivided into RTX only responders (pro-RTX, n=9), TOC only responders (pro-TOC, n=12) and refractory patients (no response to both RTX & TOC, n=32) and analysed for differential gene expression and performed gene module analysis.Results6625 genes were significantly differentially expressed between RTX responders compared to non-responders, with a predominance of antigen presentation as well as T- and B-cell genes being associated with response, while non-response was linked to fibroblast associated genes. Comparison between TOC responders and non-responders identified fewer (85) differentially expressed genes, however lymphocyte and immunoglobulin genes were also high in the synovial tissue of TOC responders similar to RTX responders, while non-responder genes and modules also included a fibroblast signature.The cross-over study design enabled comparison of rituximab-specific responders (pro-RTX), tocilizumab-specific responders (pro-TOC) and refractory patients (non-responders to both RTX & TOC, n=32) in a 3-way analysis (see Figure 1). This identified 1980 genes upregulated both in pro-RTX and pro-TOC patients, 175 genes exclusive to the pro-RTX group and 306 to the pro-TOC group, while 1277 genes were exclusive to the refractory group. While leukocyte modules and genes dominated RTX & TOC response, the refractory state was strongly associated with fibroblast genes and modules. We confirmed the observed expansion of fibroblasts from the RNA-Seq data by immunohistochemistry showing the presence of DKK3+ sublining fibroblasts in refractory rather than responder patients.ConclusionWe provide novel insights into the cellular and molecular pathways underpinning multi-biologic resistance that define a refractory RA phenotype, characterised by a stromal/fibroblast signature.References[1]Humby, F., et al. Lancet (2021)AcknowledgementsWe would like to thank all patients and the R4RA recruiting centres and principal investigators http://www.r4ra-nihr.whri.qmul.ac.uk/recruiting_centres.php We would also like to acknowledge the UK National Institute of Health Research for funding the R4RA trial (grant reference: 11/100/76) and Versus Arthritis for providing infrastructure support through the Experimental Arthritis Treatment Centre (grant number: 20022).Disclosure of InterestsNone declared.
Published: 2022
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6. SAT0024 Il-36 axis is an emerging therapeutic target in psoriatic arthritis synovial tissue

Author: M.-A. Boutet, A. Nerviani, G. Lliso-Ribera, K. Goldmann, M. Lewis, and C. Pitzalis
Published: 2018
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7. Delayed therapy with clopidogrel and everolimus prevents progression of transplant arteriosclerosis and impairs humoral alloimmunity in murine aortic allografts

Author: Bernd M. Spriewald, S. Eckl, K Goldmann, Michael Weyand, Martina Ramsperger-Gleixner, Stephan M. Ensminger, N. Koch, Raimund H.M. Preidl, and Christian Heim
Subjects: Pulmonary and Respiratory Medicine, Neointima, medicine.medical_specialty, Ticlopidine, Arteriosclerosis, medicine.medical_treatment, Urology, Mice, Isoantibodies, medicine, Animals, Platelet, Everolimus, cardiovascular diseases, Aorta, Sirolimus, Heart transplantation, business.industry, Alloimmunity, General Medicine, Allografts, Clopidogrel, medicine.disease, Immunity, Humoral, Surgery, Mice, Inbred C57BL, Transplantation, Disease Progression, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: OBJECTIVES: It was previously shown that the combination of clopidogrel and everolimus reduced the development of transplant arteriosclerosis. The aim of this study was to investigate whether delayed onset of treatment, similar to the clinical situation after heart transplantation, inhibits progression of transplant arteriosclerosis. METHODS: Fully allogeneic C57BL/6 (H2-b) donor aortas were transplanted into CBA.J (H2-k) recipients treated with clopidogrel and everolimus alone or in combination starting on Days 1, 7 or 14. Grafts were analysed by histology and alloantibodies were detected by fluorescence activated cell sorting after transplantation. RESULTS: Delayed platelet inhibition with clopidogrel reduced the development of transplant arteriosclerosis [neointima formation (Day 14): 50 ± 4 vs 84 ± 9% (control)]. The combination of clopidogrel and everolimus almost abolished formation of transplant arteriosclerosis when therapy was started on Day 1 [neointima formation (Day 1): 14 ± 5 vs 84 ± 9% (control)] and also showed a remarkable reduction in both delayed treatment groups [neointima formation (Day 7): 24 ± 7 vs 84 ± 9% (control); neointima formation (Day 14): 28 ± 11 vs 84 ± 9% (control)]. Platelet inhibition alone and in combination with everolimus resulted in reduced alloantibody production. CONCLUSIONS: These results demonstrate that delayed treatment with clopidogrel and everolimus—representative of a clinical setting— prevents the progression of transplant arteriosclerosis and impairs humoral immunity in this experimental model.
Published: 2014
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8. Attenuation of transplant arteriosclerosis by oral feeding of major histocompatibility complex encoding chitosan-DNA nanoparticles

Author: Stephan M. Ensminger, K Goldmann, J. Hoffmann, Bernd M. Spriewald, and S. Eckl
Subjects: Graft Rejection, Isoantigens, Intimal hyperplasia, medicine.medical_treatment, Immunology, Administration, Oral, Major histocompatibility complex, Major Histocompatibility Complex, Mice, Postoperative Complications, Immune system, Antigen, Animals, Immunology and Allergy, Medicine, Benzofurans, Heart transplantation, Chitosan, Mice, Inbred BALB C, Transplantation, biology, business.industry, Histology, Arteriosclerosis Obliterans, DNA, medicine.disease, Ovalbumin, Treatment Outcome, surgical procedures, operative, Chronic Disease, Mice, Inbred CBA, Quinolines, biology.protein, Heart Transplantation, Nanoparticles, Transplantation Tolerance, business
Abstract: One promising approach for the induction of transplant tolerance is the pre-treatment of transplant recipients with donor MHC-alloantigen. Our study focuses on the oral delivery of MHC-antigen encoding genes via chitosan-DNA nanoparticles to modulate the alloimmune response in order to reduce the development of transplant arteriosclerosis, the hallmark feature of chronic rejection after heart transplantation. Therefore, we performed fully allogeneic mouse abdominal aortic transplants using C57BL/6 (H2(b)) mice as donors and CBA.J (H2(k)) mice as recipients. Aortic grafts were analyzed by histology and morphometry on day 30 after transplantation, levels of circulating alloantibodies were detected by FACS analysis. Pre-treatment of recipient mice with chitosan-DNA nanoparticles encoding for K(b), one of the MHC-I molecules of the donor, resulted in a significant reduction of intimal proliferation compared to untreated controls. When Ovalbumin was fed instead of K(b) encoding nanoparticles (K(b)-NP) or Balb/c (H2(d)) grafts were used instead of C57BL/6 (H2(b)) grafts as antigen controls, both groups showed no reduction of intimal thickness indicating an antigen-specific mechanism. In addition, analysis of peripheral blood of the transplanted mice showed significant suppression of alloantibody formation in the K(b)-NP fed group compared to all other allogeneic transplanted groups suggesting modulation of the humoral immune response. These results demonstrate the potential of chitosan-DNA nanoparticles to induce K(b)-specific tolerance and to reduce the development of transplant arteriosclerosis.
Published: 2013
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9. The upgraded DO detector

Author: Vipin Bhatnagar, E. De La Cruz-Burelo, Laurent Chevalier, N. A. Kuchinsky, L. S. Vertogradov, Stephen Wimpenny, A. Bross, Y. Jacquier, Adam L. Lyon, Tiefu Zhao, N. Lahrichi, X. Zhang, T. Wlodek, B. Baumbaugh, Martin Grunewald, K. Genser, Ulrike Blumenschein, P. L.M. Podesta-Lerma, T. Marshall, Milos Lokajicek, Jean-Laurent Agram, Christian Autermann, A. Kostritski, Y. Arnoud, S. Lager, O. Dvornikov, M. Anastasoaie, U. Bassler, P. K. Mal, Darien Wood, Brad Abbott, Pierre Petroff, Sergey Denisov, D. Tompkins, P. Sheahan, S. E.K. Mattingly, M. Markus, V. Mikhailov, Chris Hays, K. J. Rani, A. Alton, V. V. Shary, L.V. Reddy, Vivek Jain, S. J. Hong, Paul Telford, Robert Hirosky, V. L. Malyshev, J. Rha, Alexander Khanov, F. Fleuret, Daniel R Claes, Yann Coadou, Nicholas John Hadley, C. P. Buszello, W. Kahl, S. Robinson, I. Churin, Regina Demina, R. Van Kooten, N. Jouravlev, Arnulf Quadt, Raimund Ströhmer, Michael A. Strauss, Michael Martens, R. Jayanti, B. Thooris, Marco Verzocchi, C. Magass, A. Besson, M. D. Corcoran, N. P. Kravchuk, V. A. Bezzubov, Elemer Nagy, G. Graham, Abdenour Lounis, A. Zieminski, Dugan O'Neil, E. G. Zverev, Joshua Thompson, R.J. Yarema, Arnaud Duperrin, H. S. Mao, V. Simak, Ted Zmuda, S. Blessing, Scott Snyder, V. S. Narasimhan, M. Abolins, J. P. Negret, D. Casey, E. Thomas, J. Huang, M. Vigneault, P. A. Rapidis, J. Lizarazo, A. M. Kalinin, V. M. Korablev, N. Spartana, Thomas Trefzger, E. J. Ramberg, S. N. Fatakia, Jaebeom Park, R. A. Sidwell, Suyong Choi, Rapson Gomez, A. Patwa, P. Padley, Denis Gelé, J. F. Bartlett, T. Moulik, R. P. Smith, Sophie Trincaz-Duvoid, M. Juarez, F. Borcherding, W. Pritchard, V. M. Podstavkov, Armen Vartapetian, R. J. Madaras, N. M. Cason, A. Goussiou, J. Steinberg, N. Gollub, R. F. Rodrigues, P. Lebrun, E. Machado, E. Hazen, R. Angstadt, D. Graham, S. N. Ahmed, B. Clement, Mitchell Wayne, D. Bonifas, Alberto Santoro, Yu. A. Gornushkin, David Colling, N. W. Reay, C. Rotolo, Christos Leonidopoulos, D. Beutel, J. Kasper, G. Sajot, J. Kozminski, Michael Shupe, Michael Hildreth, Dmitri Tsybychev, R. L. McCarthy, B. M. Sabirov, Y. Hu, C. Boswell, L. Lobo, Sascha Caron, H. Schellman, J. M. Kohli, R. DeMaat, G. Alkhazov, O. Boeriu, Marcia Begalli, J. G.R. Lima, Lorenzo Feligioni, Y. Kulik, L. Bagby, A. Yurkewicz, D. Kau, Kevin Black, Jovan Mitrevski, D. Toback, G. D. Alexeev, G. Martin-Chassard, A. Harel, Markus Klute, Sergio F Novaes, Norbert Wermes, K. Stevenson, Chris P. Barnes, B. Lavigne, Flera Rizatdinova, Ron Lipton, B. Olivier, S. Greder, Miguel Mostafa, Douglas Smith, Meenakshi Narain, Sherry Towers, Sarah Catherine Eno, Horst Severini, Ph Gris, A. Kryemadhi, Karel Smolek, J. P. Konrath, P. Schieferdecker, D. K. Cho, A. Stone, Wendy W. Davis, R. Zitoun, V. I. Rud, S. Söldner-Rembold, S. R. Hou, Alexandre Zabi, S. Uzunyan, Tobias Golling, Yonggang Huang, J. M. Hauptman, T. Scanlon, S. Kermiche, H. T. Diehl, T. A. Bolton, P. Verdier, Shuichi Kunori, Y. Pogorelov, J. Krane, P. Houben, R. Flores, K. M. Chan, Christian Zeitnitz, Cecilia Elena Gerber, Dhiman Chakraborty, V. Anosov, M. Roco, J. Womersley, Hyun-Chul Kim, John Parsons, Yurii Maravin, Junjie Zhu, F. Nang, Andrew White, R. Rechenmacher, Nikola Makovec, Mossadek Talby, B. Gómez, Yi Jiang, Suman Bala Beri, P. Laurens, M. Michaut, Gordon Watts, A. V. Kotwal, Harrison Prosper, Y. Xie, G. Ginther, D. Butler, J. Linnemann, Vivian O'Dell, H. Weerts, H. Dong, P. Ermolov, María Teresa Martín, M. Cooke, H. da Motta, D. Zieminska, M. Diesburg, D. Gillberg, A. A. Shishkin, A. Evdokimov, S. Desai, S. Grünendahl, J. Wittlin, Kristian Harder, V. Sirotenko, A. C. Le Bihan, Rupert Leitner, S. Fuess, M. Cristetiu, B. Davies, M. Wobisch, O. V. Eroshin, Y. Song, Md. Naimuddin, E. Chi, S.D. Kalmani, Shashikant Dugad, M. Merkin, Jianming Qian, J. Ellison, A. Juste, A. Melnitchouk, Steve Reucroft, Pm Tuts, P. Bonamy, Todd Adams, B. Gobbi, C. Tolian, M. Petteni, J. D. Degenhardt, S. W. Youn, E. Von Toerne, Wagner Carvalho, P. Demine, M.A. Baturitsky, J. M. Heinmiller, Hal Evans, Thomas Ferbel, A. K.A. Maciel, M. Ahsan, Sa. Jain, Dan Green, Emmanuel Busato, Alexander Leflat, V. M. Abazov, J. Raskowski, F. Touze, Nikos Varelas, L. Groer, A. M. Magnan, Thomas G Trippe, Karl Jakobs, A. Pompoš, T. Gadfort, A. S. Turcot, Phillip Gutierrez, Greg Landsberg, Sw. Banerjee, V. Hynek, Mark Raymond Adams, D. Karmanov, Q. Xu, T. Wijnen, M. Strovink, B. Connolly, L. Christofek, H. Zheng, D. Buchholz, Bing Zhou, Luis Mendoza, Lars Sonnenschein, G. Briskin, R. Hooper, D. Mendoza, T. Kurca, Pushpalatha C Bhat, S. Zviagintsev, A. Narayanan, M. B. Przybycien, Anurag Gupta, J. Lazoflores, A. Jonckheere, Marc Weber, S. Porokhovoy, P. Hanlet, Pedrame Bargassa, M. Utes, Pierre-Antoine Delsart, A. Jenkins, Helena Malbouisson, D. Chapin, Christophe Royon, Iain Alexander Bertram, V. V. Lipaev, K. Soustruznik, Kenneth Johns, M. Kopal, R. Chiche, Sudhir Malik, N. J. Buchanan, I. Ripp-Baudot, A. Meyer, P. Nagaraj, Jonas Strandberg, N. Parua, Ia Iashvili, J. Krider, R. K. Shivpuri, D. A. Stoyanova, K. Gounder, J. R. Kalk, Reiner Hauser, V. Buescher, Andrei Nomerotski, Michael Rijssenbeek, O. Atramentov, Sissel Hansen, A. Stefanik, W. D. Shephard, M. McKenna, Sharon Hagopian, K. Papageorgiou, V. Stolin, P. Skubic, Jean-Roch Vlimant, D. Skow, M. Vaz, Rodney Walker, Brajesh C Choudhary, M. Eads, M. Jaffré, M. A.C. Cummings, Raymond Brock, N. Wilcer, M. Larwill, V. Manakov, P. Tamburello, D. Coppage, G. Geurkov, J. N. Butler, R. Rucinski, Gavin Davies, Boaz Klima, P. van Gemmeren, S. Doulas, R. McCroskey, Andre Sznajder, J. Anderson, M. Doidge, L. Coney, T. Regan, Yuri Gershtein, F. Badaud, I. Katsanos, R. Beuselinck, P. D. Grannis, H. D. Wahl, T. Yasuda, V. White, S. N. Gurzhiev, A. Nurczyk, D. Wicke, Emmanuelle Perez, A. Baden, G. C. Blazey, Y. Yen, B. Zhang, Jean-Francois Grivaz, Y. A. Yatsunenko, S. H. Ahn, Arnaud Lucotte, B. Hoeneisen, Z. Ke, Alexander Kupco, J. Steele, N. A. Naumann, P.R. Vishwanath, H. J. Willutzki, J. Olsen, Y. Scheglov, Kaushik De, P. Russo, S. Baffioni, J. D. Hobbs, I. Hall, M. J. Ferreira, J. Warchol, A. Chandra, P. de Jong, Ricardo Piegaia, Florian Beaudette, M. Arov, R. Partridge, Gilvan Alves, J. Barreto, F. Yoffe, B. Satyanarayana, I.K. Prokhorov, K. Goldmann, B. Andrieu, P. Jonsson, E. Bockenthien, G. Bernardi, Freya Blekman, R. T. Neuenschwander, R. Hance, S. Tentindo-Repond, Carl Lindenmeyer, Heriberto Castilla-Valdez, D. Bauer, L. Canal, M. Bhattacharjee, F. Charles, G. Savage, I. Blackler, M. Bowden, Emanuela Barberis, Li Jingyuan, Kazunori Hanagaki, Dongliang Zhang, X. Meng, Marcel Vreeswijk, B. Spurlock, Thomas Hebbeker, M. Mulders, E.V. Komissarov, S. Chakrabarti, Peter Love, P. Johnson, P. Rubinov, T. Nunnemann, B. Baldin, A. Koubarovsky, C. Luo, Randy Ruchti, Manas Maity, M. A. Strang, J. Molina, C. Noeding, Reinhard Schwienhorst, M. H.G. Souza, Jan Stark, P. Polosov, Seo Won Lee, Henry Lubatti, Ashok Kumar, Charles Leggett, Juan Estrada, M. C. Cousinou, Julia S. Meyer, Zeno Dixon Greenwood, D. Käfer, A. Bellavance, M. Litmaath, A. A. Mayorov, K. W. Merritt, T. Vu Anh, M. Wegner, Mansoora Shamim, Carlos Avila, S. Sumowidagdo, S.A. Kahn, H. Greenlee, Sabine Crépé-Renaudin, J. Cammin, V. Oguri, C. Schwanenberger, W. M. Van Leeuwen, O. Peters, Marumi Kado, E. Galyaev, Liyuan Han, James C. Green, M. Zdrazil, Tulika Bose, S. Yacoob, C. Franklin, D. Huffman, W. M. Lee, N. Kirsch, P. Banerjee, M. Demarteau, A. Kharchilava, Z. M. Wang, David Miller, Carmen García, H. Haggerty, J. Dyer, A.A. Nozdrin, Gregory R Snow, G. Steinbrück, Andrew Brandt, S. Rapisarda, Andre Sopczak, M. Agelou, M. Binder, A. C.S. Assis Jesus, Guennadi Borissov, L. Sawyer, Philip Baringer, George Alverson, H. E. Fisk, Sergey Kuleshov, S. Protopopescu, Lev Dudko, C. Biscarat, E. Haggard, Aran Garcia-Bellido, P. Lewis, D. Hedin, M. Zanabria, Cristina Galea, Christophe Clement, D. Denisov, Elliott Cheu, S. Fu, W. C. Fisher, S. Moua, G. Gutierrez, Hwi Dong Yoo, S. Sengupta, A. S. Ito, Kirti Ranjan, H.E. Miettinen, Carsten Hensel, S. Kesisoglou, A. A. Vorobyov, A. V. Kozelov, D. Edmunds, M. Yan, S. Jabeen, Victor Daniel Elvira, S. Burke, W. E. Cooper, J. Hays, Xiuping Li, Q. Z. Li, V. V. Tokmenin, Neeti Parashar, S. Dean, Stephan Linn, A. Lobodenko, V. A. Bodyagin, Tae Jeong Kim, R. Bernhard, D. A. Wijngaarden, M. Gao, A. Cothenet, G. Hesketh, N. Oshima, M. P. Sanders, M. Zielinski, Daniel Bloch, J. Fast, Nikolay Terentyev, N. Wallace, M. Sosebee, Gustaaf Brooijmans, Sergey Burdin, A. Sanchez-Hernandez, Robert Kehoe, J. Lu, P. J. Van Den Berg, Jessica Levêque, K. Bos, Marc Besancon, J. Temple, T. Christiansen, Bobby Samir Acharya, H. A. Neal, Sung Keun Park, D. Meder, H. C. Shankar, V. Sorín, T. R. Wyatt, V. Zutshi, V. Vysotsky, B. G. Pope, M. A. Kubantsev, B. O. Oshinowo, W. Barg, Marvin Johnson, A. A. Schukin, M. R. Krishnaswamy, Sebastian Grinstein, O. Kouznetsov, E. Flattum, R. Yamada, M. Warsinsky, O. Bardon, T. Edwards, K. Yip, N. Xuan, L. Stutte, R. D. Schamberger, Timothy Andeen, R. E. Ray, L. Lueking, K. Krempetz, C. Miao, W. L. Prado Da Silva, S. Chopra, Andrew Askew, Zhengguo Zhao, Brigitte Vachon, D. Evans, Gregory J Pawloski, A.S. Dyshkant, M. Buehler, Jiri Kvita, V.V. Teterin, M. Lynker, J. Yu, X. F. Song, M. V. S. Rao, N. R. Stanton, J. Torborg, N. K. Mondal, Lev Uvarov, G. Le Meur, D. Shpakov, R. Jesik, S. Beauceron, Ariel Schwartzman, Melissa Ridel, Dorothee Schaile, G. Cisko, T. C. Bacon, Alexey Ferapontov, M. Wetstein, J. Bystricky, Zhenbin Wu, J. Foglesong, J. Fagan, Robert Harrington, A. Mendes, T. Fitzpatrick, Christian Schmitt, S. Nelson, R. Gelhaus, H. E. Montgomery, C. De La Taille, P. Mättig, K. Gray, E. Popkov, M. Hohlfeld, K. Del Signore, R. Illingworth, C. Han, D. Mihalcea, C. De Oliveira Martins, Victor Golovtsov, P. N. Ratoff, Emily Nurse, Elizabeth Gallas, T. McMahon, Maksym Titov, V. E. Kuznetsov, V. Gavrilov, D. Olis, Wendy Taylor, Allan G Clark, Roger Moore, R. Goodwin, Johannes Elmsheuser, J. T. Eltzroth, P. Neustroev, Laurent Duflot, David Cutts, R. Ramirez-Gomez, R. Kwarciany, Rupinder Kaur, Daniel Whiteson, Bradley Cox, S. J. De Jong, B. Kothari, J. Coss, D. Markley, A. A. Shchukin, L. Babukhadia, Frank Fiedler, E. Kajfasz, A. Magerkurth, A. Zatserklyaniy, N.A. Russakovich, M. Das, V. N. Evdokimov, Gervasio Gomez, Michael Begel, Eduardo De Moraes Gregores, G. A. Davis, Boris Tuchming, Luiz Mundim, J. F. Renardy, Limin Wang, Marc-Andre Pleier, M. Doets, N.V. Mokhov, B. Åsman, A. P. Heinson, T. H. Burnett, G. S. Muanza, R. E. Hall, D. Fein, M. Fortner, Don Lincoln, Erich Varnes, P. W. Balm, C. Hebert, Ulrich Heintz, M. Matulik, A. Bishoff, H. Jöstlein, S. Krzywdzinski, J. Green, A. Zylberstejn, Frank Filthaut, R. Kubinski, F. Lehner, D. M. Strom, B. C.K. Casey, Y. P. Merekov, E. Shabalina, J. Guglielmo, Kyoung-Ho Kim, Andy Haas, L. Phaf, G. W. Wilson, Frederic Deliot, Christopher George Tully, Y. M. Kharzheev, Patrick Slattery, G. J. Otero y Garzón, T. Toole, S. Uvarov, A. Boehnlein, H. L. Melanson, Ivor Fleck, J. Snow, B. Quinn, J. H. Christenson, Makoto Tomoto, David H. Adams, Alice Bean, F. Canelli, N. Oliveira, Maria Elena Pol, W. Gu, A. P. Kaan, J. Gardner, R. Choate, Walter Freeman, J. Kotcher, S. Anderson, Harald Fox, M. Vaupel, Y. D. Mutaf, I. A. Vasilyev, P. M. Perea, and F. Villeneuve-Seguier
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Tevatron, 01 natural sciences, Particle detector, law.invention, Nuclear physics, Data acquisition, law, 0103 physical sciences, Fermilab, 010306 general physics, Collider, Instrumentation, Physics, 010308 nuclear & particles physics, business.industry, Detector, Electrical engineering, Particle accelerator, D0 experiment, Experimental High Energy Physics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Physics::Accelerator Physics, High Energy Physics::Experiment, business
Abstract: The DØ experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid-argon calorimeters and central muon detector, remaining from Run I, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to DØ. © 2006 Elsevier B.V. All rights reserved.
Published: 2016

10. Oral Gene Application Using Chitosan-DNA Nanoparticles Induces Transferable Tolerance

Author: Bernd M. Spriewald, K Goldmann, and Stephan M. Ensminger
Subjects: CD4-Positive T-Lymphocytes, Microbiology (medical), Adoptive cell transfer, Ovalbumin, Clinical Biochemistry, Immunology, T-Lymphocytes, Regulatory, Antibodies, Immune tolerance, Mice, Immune system, Antigen, Immune Tolerance, medicine, Animals, Immunologic Factors, Immunology and Allergy, IL-2 receptor, Cell Proliferation, Autoimmune disease, Chitosan, Drug Carriers, Mice, Inbred BALB C, Vaccines, biology, Gene Transfer Techniques, DNA, respiratory system, medicine.disease, Adoptive Transfer, biology.protein, Cytokines, Nanoparticles, Antibody
Abstract: Oral tolerance is a promising approach to induce unresponsiveness to various antigens. The development of tolerogenic vaccines could be exploited in modulating the immune response in autoimmune disease and allograft rejection. In this study, we investigated a nonviral gene transfer strategy for inducing oral tolerance via antigen-encoding chitosan-DNA nanoparticles (NP). Oral application of ovalbumin (OVA)-encoding chitosan-DNA NP (OVA-NP) suppressed the OVA-specific delayed-type hypersensitivity (DTH) response and anti-OVA antibody formation, as well as spleen cell proliferation following OVA stimulation. Cytokine expression patterns following OVA stimulationin vitroshowed a shift from a Th1 toward a Th2/Th3 response. The OVA-NP-induced tolerance was transferable from donor to naïve recipient mice via adoptive spleen cell transfer and was mediated by CD4+CD25+T cells. These findings indicate that nonviral oral gene transfer can induce regulatory T cells for antigen-specific immune modulation.
Published: 2012
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11. Geplante Entfernung der Kehlkopfmaske im Aufwachraum

Author: K. Goldmann, C. Bornträger, S. Kuhlmann, and M. Gerlach
Subjects: medicine.medical_specialty, business.industry, Pain medicine, General Medicine, Sevoflurane, Fentanyl, Anesthesiology and Pain Medicine, Anesthesia, Anesthesiology, Medicine, Consciousness monitors, Anesthesia Recovery Period, business, medicine.drug
Abstract: Hintergrund Die Entfernung der Kehlkopfmaske im Aufwachraum (AWR) konnte moglicherweise zu einer Beschleunigung der Uberleitung von einer Operation auf die folgende beitragen. Mithilfe der vorgestellten Untersuchung sollten daher Erkenntnisse uber die mogliche Zeitersparnis und Patientensicherheit bei einer geplanten Entfernung der ProSeal®-Kehlkopfmaske (PLMA) im AWR gewonnen werden.
Published: 2011
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12. ProSeal®-Kehlkopfmaske in normalgewichtigen und adipösen Patienten

Author: K. Goldmann, M. Gerlach, and C. Bornträger
Subjects: Gynecology, medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, medicine, General Medicine, respiratory system, business
Published: 2011
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13. Klinischer Einsatz der ProSeal®-Kehlkopfmaske bei Säuglingen, Kindern und Jugendlichen

Author: C. Hechtfischer, K. Goldmann, and A. Malik
Subjects: Gynecology, medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, medicine, General Medicine, business
Abstract: Im Gegensatz zu Erwachsenen sind die wissenschaftlichen Daten uber den Einsatz der ProSeal®-Kehlkopfmaske (PLMA) bei Sauglingen, Kindern und Jugendlichen bisher eher begrenzt und stammen uberwiegend aus kontrollierten Studien, die an einer geringen Zahl von Probanden durchgefuhrt wurden. Mithilfe der vorgestellten Untersuchung sollten Erkenntnisse uber Art, Effektivitat und Sicherheit der Routineanwendung der PLMA bei einer groseren Zahl von nichterwachsenen Patienten im Routinebetrieb einer Universitatsklinik gewonnen werden. Im Rahmen einer prospektiven Anwendungsbeobachtung wurden mithilfe eines standardisierten Dokumentationsbogens folgende Informationen uber den Einsatz der PLMA bei Patienten bis zu einem Alter von 18 Jahren erhoben: Anwendercharakteristika, Patientencharakteristika, Art und Dauer der Operation, Details des Atemwegsmanagements, Details des Anasthesieverfahrens, PLMA anwendungsassoziierte Anasthesieverlaufsbeobachtungen und postoperativer Status der Patienten. Insgesamt 61 Anasthesisten (32% Facharzte, 68% Assistenzarzte) dokumentierten 512 Anwendungen. Eine erfolgreiche Platzierung gelang bei 99% der Patienten mit maximal 3 Platzierungsversuchen. Der initiale Leckagedruck betrug dabei 27 cm H2O (Variationsbreite 12–40 cm H2O). Bei 96% der Patienten wurde ein kontrolliertes Beatmungsverfahren eingesetzt. Klinisch relevante Anasthesieverlaufsbeobachtungen wurden in 3,3% der Patienten dokumentiert; hiervon wurden 0,6% als schwerwiegend klassifiziert. In 1,6% der Anwendungen wurde die PLMA durch einen Endotrachealtubus ersetzt. Bei 2 Patienten wurde die PLMA nach gescheiterter endotrachealer Intubation erfolgreich eingesetzt. Bei 6 Patienten wurde die Drainage von Magensekret durch den Drainageschlauch der PLMA dokumentiert. Die PLMA kann bei Sauglingen, Kindern und Jugendlichen erfolgreich im Routinebetrieb einer Universitatsklinik verwendet werden. Die Ergebnisse unterstutzen die Annahme, dass bei der PLMA regurgitiertes Magensekret durch den Drainageschlauch am Kehlkopf vorbei abgeleitet werden kann.
Published: 2011
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14. Leckagedruck der ProSeal®-Kehlkopfmaske

Author: K Goldmann and C Freisburger
Subjects: Leak, business.industry, medicine.medical_treatment, Remifentanil, General Medicine, Laryngeal Masks, Anesthesiology and Pain Medicine, Laryngeal mask airway, Anesthesia, Medicine, Intubation, Tube (fluid conveyance), business, Airway, Propofol, medicine.drug
Abstract: Background The ProSeal laryngeal mask airway (PLMA) has been studied in numerous investigations and the airway leak pressure (P(leak)) is often used as a primary end-point, particularly in comparative studies with other supraglottic airway devices. The PLMA offers the opportunity to place a gastric tube through the drain-tube and P(leak) measurement can take place both with and without a gastric tube. With this study we tested the hypothesis that the use of a gastric tube influences the P(leak). Methods The P(leak) of the PLMA was studied in 98 patients under total intravenous anaesthesia with propofol (0.1-0.15 mg*kgBW-1*min-1) and remifentanil (0.1-0.3 microg*kgBW-1*min-1) before and after placement of a gastric tube through the drain-tube of the PLMA. Results There was no significant difference between the mean baseline P(leak) without a gastric tube in place (25+/-6.3 cm H(2)O) and the mean P(leak) after placement of a gastric tube (25+/-6.7 cm H2O; p=0.6). Conclusion Placement of a gastric tube through the drain-tube of the PLMA does not influence the P(leak). Providing the same method of measurement has been used, P(leak) values from different studies obtained with or without a gastric tube in place are comparable.
Published: 2006
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15. Airway management practices at German university and university-affiliated teaching hospitals - equipment, techniques and training: results of a nationwide survey

Author: Ulrich Braun and K. Goldmann
Subjects: medicine.medical_specialty, medicine.medical_treatment, education, Endotracheal intubation, Nationwide survey, Laryngeal Masks, Fibreoptic intubation, Hospitals, University, German, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology, 030202 anesthesiology, Intubation, Intratracheal, medicine, Fiber Optic Technology, Humans, Hospitals, Teaching, Intensive care medicine, Difficult airway, Laryngoscopy, business.industry, 030208 emergency & critical care medicine, General Medicine, respiratory system, medicine.disease, Expert group, humanities, language.human_language, 3. Good health, Anesthesiology and Pain Medicine, language, Airway management, Medical emergency, Airway, business
Abstract: Background: Until recently, Germany did not have national airway management guidelines. This survey collected comprehensive data on departmental airway management practices from German teaching institutions to identify weaknesses, and the results are presented here. German national airway guidelines were formulated by an expert group on the basis of these data and the current evidence in the literature. Methods: Questionnaires were mailed to the directors of 452 university and university-affiliated anaesthesia departments. They were asked to respond to 39 questions on the use of particular equipment and techniques, management of the difficult airway and training in airway management. Results: Two hundred and twelve questionnaires were returned. Many alternative devices for endotracheal intubation, such as the Bullard® laryngoscope, the Bonfils® laryngoscope and the Trachlight®, are not used in the majority (80%) of departments. Thirty-six per cent of departments do not have difficult airway carts. No departmental difficult airway management plan is used in 22% of departments. Patients are not provided with written information on their personal airway management difficulties in 14% of departments. Structured training in the form of block rotation is offered in only 29–40% of departments. Although trainees perform fibreoptic intubation (FOI) in most departments, appropriate training in FOI is not available in some departments (8%). Conclusion: There are deficits in various areas of airway management, in particular training and the use of algorithms. International guidelines and recommendations are not followed by a large number of German teaching institutions. The provision of German national airway guidelines should improve this situation.
Published: 2006
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16. Einsatz der Kehlkopfmaske in der anästhesiologischen Praxis deutscher Universitäts- und Lehrkrankenhäuser - Ergebnisse einer bundesweiten Umfrage

Author: K. Goldmann and U. Braun
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, General surgery, Frequency of use, General Medicine, Controlled ventilation, Critical Care and Intensive Care Medicine, humanities, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Laryngeal mask airway, Anesthesia, Throat, Emergency Medicine, Medicine, General anaesthesia, Airway management, Eye surgery, business, Nose
Abstract: AIM OF THE STUDY The aim of this study was to collect comprehensive data on the use of the laryngeal mask airway (LMA) under general anaesthesia at German university and university-affiliated hospitals. METHODS Questionnaires were mailed to the directors of 452 German university and university-affiliated anaesthesia departments. Twenty-three questions related to the way and frequency of use of the LMA were asked. RESULTS Data from 212 departments (47 %) could be included into the analysis. The LMA is used in all departments. Depending on the size of the department the LMA is used in 1 - 60 % of all anaesthetics. The LMA is used significantly more often (p > 0.001) in smaller departments providing up to 10 000 anaesthetics per year compared to larger departments providing up to, or more than, 20 000 anaesthetics per year. Controlled ventilation is the preferred mode of ventilation in more than 75 % of all departments. The LMA is used "routinely" or "always" for operations lasting more than 1 hour in more than 75 % of all departments. The LMA is used in the areas of ear, nose, and throat, maxillofacial, and eye surgery "routinely" or "always" only in 11 - 26 % of all departments. CONCLUSION The role of the LMA in routine anaesthesia practice has clearly increased. Controversial aspects of use are reflected in the practice patterns of LMA use in different departments. The LMA has not been disseminated widely in the areas of ear, nose and throat-, maxillofacial- and eye surgery.
Published: 2005
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17. Atemwegssicherung mit der Kehlkopfmaske in der Kinderanästhesie - Allgemeine Aspekte und Neuerungen der ProSeal®-LMA

Author: K. Goldmann
Subjects: Anesthesiology and Pain Medicine, Emergency Medicine, General Medicine, Critical Care and Intensive Care Medicine
Published: 2004
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18. Monitoring of Hematopoietic Chimerism by Real-Time Quantitative PCR of Micro Insertions/Deletions in Samples with Low DNA Quantities

Author: Wolf Roesler, Julia Winkler, Christian Bach, Andreas Mackensen, K Goldmann, Volker Weisbach, Elmira Tomova, and Bernd M. Spriewald
Subjects: medicine.medical_treatment, Hematology, Hematopoietic stem cell transplantation, Biology, Molecular biology, Donor lymphocyte infusion, law.invention, chemistry.chemical_compound, Real-time polymerase chain reaction, chemistry, law, Medizinische Fakultät, medicine, Immunology and Allergy, Original Article, Typing, ddc:610, Primer (molecular biology), Indel, Polymerase chain reaction, DNA
Abstract: Background: Sensitive and accurate methods to detect hematopoietic chimerism after hematopoietic stem cell transplantation (HSCT) are essential to evaluate engraftment and to monitor response to therapeutic procedures such as donor lymphocyte infusion. Continuous long-term follow up, however, requires large amounts of pre-HSCT samples limiting the application of many widely used techniques for sensitive chimerism monitoring. Methods: DNAs from 42 normal healthy donors and 16 HSCT donor/recipient pairs were employed to validate the use of allele-specific insertion/deletion (indel) quantitative real-time polymerase chain reaction (qPCR) to quantify chimerism in samples with low amounts of DNA. Consequently, indel-qPCR analyses of samples from 16 HSCT patients were compared to short-tandem repeat (STR) specific PCR analyses. Results: Typing with reduced amounts of input DNA (15 vs. 60 ng) allowed for the reliable distinction of positive (mean threshold cycle (ct) 28.05) and negative (ct >36) signals. The high informativity of primer/probe sets, with 12 out of 19 markers exceeding 20% informativity, was confirmed in our cohort (n = 74). Importantly, a fourfold reduction of input DNA compared to published protocols did not alter PCR efficiencies and allowed for a more sensitive detection of chimerism in 7 of 16 HSCT patients compared to results obtained by STR-PCR. Conclusions: Our data suggest that indel-qPCR is a more sensitive technique for the detection of hematopoietic chimerism compared to STR-PCR and works efficiently for samples with low amounts of DNA.
Published: 2015

19. A multi channel dosimeter based on scintillating fibers for medical applications

Author: K Goldmann, I. M. Gregor, K. H. Becks, M Heintz, and J. Drees
Subjects: Physics, Nuclear and High Energy Physics, Scintillation, Photomultiplier, Dosimeter, business.industry, Image intensifier, Scintillator, law.invention, Optics, law, Absorbed dose, Dosimetry, Electric current, business, Instrumentation
Abstract: Dosimetry with plastic scintillators is an interesting alternative for the measurement of the absorbed dose. A scintillator does barely disturb the radiation field due to its mass absorption coefficients which is water-equivalent in a wide range of energies. Furthermore, plastic scintillation dosimeters provide a fast and direct reading of the measured value combined with a high-spatial resolution. In the set-up described so far, the light produced by the scintillators was transported via light-guides to single-channel or multi-channel photomultipliers to be transformed into an electric current read out by pico-amperemeters. The use of photomultipliers becomes expensive and complicated for a dosimeter system with many parallel channels. For such applications, an image intensifier coupled to a CCD is a simpler approach which can read out some 80 fibers in parallel [M. Garg, Konzeption, Aufbau and Test eines Vielkanal-Dosimeters mit szintillierenden Fasern, WUB–DIS 96–17, Universitat Wuppertal, 1996 and I.M. Gregor, Ein Vielkanaldosimeter mit szintillierenden Fasern–Klinische Messungen bei Energien oberhalb 1 MeV, WU D 98–14, Universitat Wuppertal, 1998]. In this note, the design and the first successful measurements of a prototype set-up are described.
Published: 2000
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20. Kann Sevofluran im klinischen Alltag den zeitlichen Ablauf beschleunigen?

Author: Ulrich Braun, K. Hahnenkamp, O. Thomas, and K. Goldmann
Subjects: Gynecology, medicine.medical_specialty, Anesthesiology and Pain Medicine, Spontaneous ventilation, business.industry, medicine, General Medicine, business
Abstract: Fragestellung: Das Narkosegas Sevofluran zeigt ein rasches Aufwachverhalten. Wir uberpruften, ob Sevofluran in der Ausleitungsphase bei Kindernarkosen in der klinischen Routine zu einem Zeitgewinn gegenuber Halothan fuhren kann. Methodik: Die Patienten im Alter zwischen 4–14 Jahren (ASA I) wurden randomisiert der Halothan- oder der Sevoflurangruppe zugeteilt. Alle Patienten wurden uber eine flexible Larynxmaske kontrolliert beatmet (pCO2 zwischen 38 und 42 mm Hg). Die Narkosegase wurden nach der Spektralen Eckfrequenz 90 (SEF 90) des pEEG dosiert. Jede Narkose war zum Zeitpunkt des Mesbeginns vergleichbar tief (SEF 90 zwischen 8 und 12 Hz). Ermittelt wurden die Zeitintervalle: Beendigung der Narkotikazufuhr – Einsetzen der Spontanatmung (Phase 1); Einsetzen der Spontanatmung – Entfernung der Kehlkopfmaske (Phase 2); SEF 90 Intervall. Ergebnisse: 18 Patientendaten wurden ausgewertet (Halothan n=8; Sevofluran n=10). Zwischen Narkoseende und Entfernung der Larynxmaske bestand ein Zeitgewinn fur die Sevoflurangruppe von 6,8 min (Median) (p 0,05). Diskussion: Sevofluran verkurzt die Uberleitungszeiten in der Kinderanasthesie. Auswirkungen ergeben sich besonders in Operationsbereichen mit hohem Patientenumsatz.
Published: 1998
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21. Identification of the novel HLA-C*07:315 allele

Author: K, Goldmann, B, Lauer, and B M, Spriewald
Subjects: Base Sequence, Molecular Sequence Data, Humans, Exons, HLA-C Antigens, Sequence Alignment, Alleles
Abstract: The HLA-C*07:315 allele is mostly identical to HLA-C*07:09 but has a non-synonymous substitution of C to G in exon 2.
Published: 2013

22. Attenuation of transplant arteriosclerosis by oral feeding of MHC encoding chitosan-DNA nanoparticles is mediated by humoral immunity

Author: Stephan M. Ensminger, S. Eckl, Bernd M. Spriewald, Christian Heim, K Goldmann, and M. Weyand
Subjects: Pulmonary and Respiratory Medicine, biology, business.industry, Dna nanoparticles, Transplant arteriosclerosis, Major histocompatibility complex, Chitosan, chemistry.chemical_compound, chemistry, Humoral immunity, Immunology, biology.protein, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Oral feeding
Published: 2013
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23. Oral gene application using chitosan-DNA nanoparticles induces transferable tolerance

Author: Stephan M. Ensminger, Christian Heim, Bernd M. Spriewald, and K Goldmann
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Dna nanoparticles, Surgery, Chitosan, chemistry.chemical_compound, Biochemistry, chemistry, Medicine, Cardiology and Cardiovascular Medicine, business, Gene
Published: 2013
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24. [ProSeal™laryngeal mask in normal weight and obese patients : oxygenation under pressure-controlled ventilation and different end-expiratory pressures]

Author: K, Goldmann, M, Gerlach, and C, Bornträger
Subjects: Adult, Male, Air Pressure, Adolescent, Body Weight, Middle Aged, Respiration, Artificial, Laryngeal Masks, Body Mass Index, Intermittent Positive-Pressure Ventilation, Oxygen, Positive-Pressure Respiration, Young Adult, Humans, Female, Obesity, Blood Gas Analysis, Aged
Abstract: Most of the data on combining pressure-controlled ventilation (PCV) with positive end-expiratory pressure (PEEP) come from studies with an endotracheal tube (ETT) whereas data on utilization of PEEP with a laryngeal mask airway (LMA) are limited. The LMA-ProSeal® (PLMA) forms a more effective seal of the airway than the LMA-Classic™ (CLMA). The application of PEEP when PCV is used with the PLMA could have an impact on oxygenation in adult patients.For this study 148 patients with an mean age of 44 years (range18-65 years) and mean weight of 86 kg (range 49-120 kg) were recruited in 2 groups: group N ((Normal)): body-mass index (BMI)30 kg/m(2) and group O ((Obesity)) BMI ≥30 and36 kg/m(2). Cardiovascular and pulmonary disease and a history of smoking were exclusion criteria in addition to the usual LMA contraindications. The bispectral index-guided (BIS) anesthesia technique was used with propofol, fentanyl, and remifentanil without muscle relaxants. Measurement of PLMA seal pressure served as recruitment maneuver and PCV was randomly combined with 0 cmH(2)O, 5 cmH(2)O or 8 cmH(2)O PEEP. An arterial blood gas sample was taken 50 min after induction of anesthesia under an inspiratory oxygen fraction (F(I)O(2)) of 0.3. In the first part partial oxygen pressure (p(a)O(2)) under 0 cmH(2)O was compared with p(a)O(2) under 5 cmH(2)O and in the second part p(a)O(2) under 5 cmH(2)O was compared with p(a)O(2) under 8 cmH(2)O. A significant difference was set as p0.025.The PLMA could be placed after 3 attempts in 147 patients. The mean seal pressure was in the range of 24-30 cm H(2)O. Application of randomized PEEP was possible in all patients and ventilation was comparable between corresponding groups. In group N no differences were found in part 1 (139±28 vs. 141±28 mmHg, p=0.88) or part 2 (127±24 vs. 134±26 mmHg, p=0.35). In group O there was a significant difference in p(a)O(2) in part 1 (75±12 vs. 94±18 mmHg, p=0.02) but not in part 2 (92±21 vs. 103±18 mmHg, p=0.04).The application of PEEP when PCV is used with the PLMA results in improved oxygenation in obese patients with a BMI ≥30 and36 kg/m(2) but not in normal weight patients. Alveolar recruitment produced by seal pressure measurements below 30 cm H(2)O was sufficient to produce a clinically significant improvement in oxygenation in most obese patients and there was a significant improvement of oxygenation with PEEP=5 cmH(2)O. Both findings are in contrast to findings of studies using an ETT which suggests that higher pressures (40 cmH(2)O) are needed for recruitment of collapsed alveoli and higher PEEP (10 cmH(2)O) is needed to produce a clinically significant improvement in oxygenation in obese patients. The results of this study support data showing that the consequences of bronchopulmonary airway reactions known to occur with an ETT are less pronounced or absent when an LMA is used.
Published: 2011

25. [Removal of the laryngeal mask airway in the post-anesthesia care unit. A means of process optimization?]

Author: K, Goldmann, S, Kuhlmann, M, Gerlach, and C, Bornträger
Subjects: Adult, Male, Methyl Ethers, Adolescent, Anesthesia, General, Laryngeal Masks, Sevoflurane, Young Adult, Consciousness Monitors, Postoperative Complications, Physicians, Task Performance and Analysis, Humans, Anesthesia, Oximetry, Prospective Studies, Aged, Aged, 80 and over, Middle Aged, Fentanyl, Oxygen, Anesthesia Recovery Period, Anesthetics, Inhalation, Female, Patient Safety, Anesthetics, Intravenous, Recovery Room
Abstract: Removal of the laryngeal mask airway in the post-anesthesia care unit could potentially contribute to a faster turnover from one operation to the next. The aim of this study was, therefore, to obtain an insight into the potential time saving and the safety of planned removal of the ProSeal™-LMA (PLMA) in the post-anesthesia care unit.In this study 120 adult patients with American Society of Anesthesiologists (ASA) classification I-II, age range 18-85 years, undergoing a surgical procedure under general anesthesia in which the PLMA was used were randomly assigned to one of two groups. In group I, the PLMA was removed in the awake patient in the operating room close to the end of the procedure. In group II, the anesthetised but spontaneously breathing patients were moved to the recovery room and the PLMA removed when the patient was awake. The anesthesia technique was standardized [balanced, sevoflurane, fentanyl, bispectral index-guided (BIS) target value=35±5] and identical in both groups until randomization. Patients were breathing room air during transport to the recovery room. Different time intervals as well as the incidence of critical incidents were compared between groups. An oxygen saturation (S(p)O(2)) value95% was considered a clinically relevant and S(p)O(2) values90% as clinically critical O(2)-desaturation.Removal of the PLMA took place after an average of 4.9±5.1 min in group I and after 19.5±9.6 min in group II. There was no difference in the availability of the anesthetist in the operating room for the following procedure between groups (group I: 12±5.6 min vs. group II: 10.7±4.2 min, p0.05) despite the fact that patients of group II left the operating room faster (4.9±3.9 min) than patients of group I (7.1±5.1 min, p0.01). In group II patients were ready for discharge (White score=12) from the recovery room later (13.2±8.2 min) than in group I (3.6±4.8 min, p0.01). There were no significant differences in other process related time intervals between group I and group II: duration of the operation (113.2±45.9 min vs. 105.3±42.6 min), duration of dressing (5.1±3.7 min vs. 4.6±2.8 min), duration of transport to the recovery room (3.9±1.3 min vs. 3.6±1.3 min) and information at end of surgery by the surgeon (22.5±9.3 min vs. 22.4±10.5 min). The incidence of clinically relevant as well as clinically critical O(2) desaturation at the time of recovery room arrival (S(p)O(2)≤90%) was increased in group II with 33.3% vs. 56.6% and 13.3% vs. 6.7%, p0.01, respectively.Planned PLMA removal in the recovery room after BIS-guided balanced anesthesia did not enable the anesthetist to be available earlier for induction of anesthesia in the following patient. Hence the anesthetist could not contribute to a faster turnover of cases. Obviously, with the type of close communication between surgeon and anesthetist dictated by the study protocol (announcement of expected end of surgery by the surgeon 20 min before end of surgery) it is possible for the patient to regain consciousness within a very small time window following the end of surgery. Following this kind of protocol, postponement of removal of the LMA in the recovery room does not seem to be attractive neither from a clinical nor an economic point of view. In contrast, removal of LMA in the recovery room should be restricted to occasional cases with an abrupt end of the operation or prolonged emergence from anesthesia. The obvious risk of hypoxemia necessitates continuous O(2) application and S(p)O(2) monitoring during transport to the recovery room.
Published: 2011

26. Delayed therapy with Clopidogrel and Everolimus substantially inhibits the development of transplant arteriosclerosis

Author: S. Abele-Ohl, Christian Heim, S. Eckl, M. Weyand, Martina Ramsperger-Gleixner, Stephan M. Ensminger, and K Goldmann
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Everolimus, business.industry, Internal medicine, Transplant arteriosclerosis, medicine, Cardiology, Surgery, Cardiology and Cardiovascular Medicine, Clopidogrel, business, medicine.drug
Published: 2011
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27. Reduced humoral immunity after treatment with Clopidogrel and Everolimus in a murine aortic allograft model

Author: Stephan M. Ensminger, Christian Heim, Martina Ramsperger-Gleixner, S. Abele-Ohl, S. Eckl, K Goldmann, and M. Weyand
Subjects: Pulmonary and Respiratory Medicine, Everolimus, business.industry, Immunology, Humoral immunity, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Clopidogrel, After treatment, medicine.drug
Published: 2011
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28. [Clinical use of the ProSeal™ laryngeal mask in infants, children and adolescents : prospective observational survey]

Author: K, Goldmann, A, Malik, and C, Hechtfischer
Subjects: Male, Adolescent, Infant, Newborn, Masks, Infant, Documentation, Anesthesia, General, Laryngeal Masks, Child, Preschool, Task Performance and Analysis, Anesthesia, Intravenous, Intubation, Intratracheal, Humans, Female, Prospective Studies, Treatment Failure, Anesthesia, Inhalation, Child
Abstract: In contrast to the adult population scientific data on ProSeal™-LMA (PLMA) usage in infants, children, and adolescents are rather limited. Most data have been generated by expert users in studies on small numbers of patients. The aim of this study was to gather comprehensive data about the characteristics, efficacy and safety of its routine use in children at a teaching institution.Using a standardized reporting form the following data were collected in the course of a prospective survey on PLMA usage in patients aged up to 18 years: user characteristics, patient characteristics, type and duration of operation, details of airway management and anesthetic technique, details of PLMA usage-related critical incidents and postoperative status of the patient.Use of the PLMA was documented in 512 patients by 61 anesthesiologists (32% staff grade, 68% trainees). The average age, height and weight of the patients was 8 years (range 0-17 years), 130 cm (range 54-193 cm) and 29 kgBW (range 5-130 kgBW), respectively. Anesthesia was induced intravenously in 458 patients (89.5%) and by inhalation in 54 patients. Maintenance of anesthesia was by total intravenous anesthesia (propofol) in 184 patients (36.5%) and by an inhalational agent (sevoflurane or desflurane) in 320 patients (63.7%). Neuromuscular blocking agents were used in 7 patients (1.4%). The patients were anesthetized for an average of 80 min (range 15-270 min) and insertion success rate was 99% with a maximum of 3 attempts. The average initial airway leak pressure was 27cm H(2)O (range 12-40 cm H(2)O); however, lower pressures were recorded for smaller size masks (size 1.5-2.5) without a dorsal cuff than for larger size masks (size 3-5; p0.01). Ventilation was controlled in 96% and combined with PEEP in 39% of cases. Critical incidents associated with PLMA were documented in a total of 8.4% of cases, the majority being minor trauma, evidenced by blood on the PLMA on removal, followed by some form of airway obstruction. In 3.3% of cases these incidents were judged as clinically relevant of which 0.6% were classified as serious. Twice as many problems occurred during induction of anesthesia as in the maintenance phase and emergence phase of anesthesia (p=0.037). In 1.6% the PLMA was abandoned in favor of the endotracheal tube. In 7 patients the PLMA was exchanged in the induction room whereas in 1 patient this took place intraoperatively. Failure of ProSeal™ laryngeal mask use correlated with the level of PLMA use experience with 75% of failures caused by users with an experience of less than 50 uses and no failure in users with an experience of more than 100 uses. Failure did not correlate with the size of the mask. In 2 cases the PLMA was successfully used after failed endotracheal intubation. In 6 patients drainage of regurgitated gastric fluid through the drain tube was documented. No long-term adverse sequelae resulted in any patient.This survey demonstrates that the PLMA can be used effectively in infants, children and adolescents in the routine university clinical practice setting. However, this study does not confirm the extremely high success and low complication rates reported in controlled studies. The results support the assumption that with the PLMA regurgitated gastric fluid can be drained away from the larynx through the drain tube.
Published: 2010

29. [Airway leak pressure of the ProSeal laryngeal mask airway. Comparison with and without a gastric tube placed through the drain-tube]

Author: C, Freisburger and K, Goldmann
Subjects: Adult, Male, Air Pressure, Middle Aged, Laryngeal Masks, Body Mass Index, Remifentanil, Piperidines, Anesthesia, Intravenous, Humans, Female, Intubation, Gastrointestinal, Propofol, Anesthetics, Intravenous, Aged
Abstract: The ProSeal laryngeal mask airway (PLMA) has been studied in numerous investigations and the airway leak pressure (P(leak)) is often used as a primary end-point, particularly in comparative studies with other supraglottic airway devices. The PLMA offers the opportunity to place a gastric tube through the drain-tube and P(leak) measurement can take place both with and without a gastric tube. With this study we tested the hypothesis that the use of a gastric tube influences the P(leak).The P(leak) of the PLMA was studied in 98 patients under total intravenous anaesthesia with propofol (0.1-0.15 mg*kgBW-1*min-1) and remifentanil (0.1-0.3 microg*kgBW-1*min-1) before and after placement of a gastric tube through the drain-tube of the PLMA.There was no significant difference between the mean baseline P(leak) without a gastric tube in place (25+/-6.3 cm H(2)O) and the mean P(leak) after placement of a gastric tube (25+/-6.7 cm H2O; p=0.6).Placement of a gastric tube through the drain-tube of the PLMA does not influence the P(leak). Providing the same method of measurement has been used, P(leak) values from different studies obtained with or without a gastric tube in place are comparable.
Published: 2006

30. [Influence of neuromuscular blockade on the airway leak pressure of the ProSeal laryngeal mask airway]

Author: K, Goldmann, N, Hoch, and H, Wulf
Subjects: Adult, Air Pressure, Muscle Relaxation, Middle Aged, Laryngeal Masks, Remifentanil, Piperidines, Neck Muscles, Anesthesia, Intravenous, Neuromuscular Blockade, Humans, Female, Androstanols, Rocuronium, Propofol, Anesthetics, Intravenous, Aged, Neuromuscular Nondepolarizing Agents
Abstract: The ProSeal laryngeal mask airway (PLMA) is increasingly used for surgical procedures that might require the intraoperative use of neuromuscular blocking agents. The airway seal of the PLMA depends on the interplay of the surrounding soft tissue of the neck and the cuff of the mask. An intraoperative neuromuscular blockade could lead to a decrease of the airway leak pressure (P (leak)) secondary to the relaxation of the muscles of the neck. With this study we tested the hypothesis that a neuromuscular blockade can result in a decreased P (leak) of the PLMA.The P (leak) of the PLMA was studied in 73 female patients under total intravenous anaesthesia with propofol (0.1 - 0.15 mg kg (-1) min (-1)) and remifentanil (0.1 - 0.3 microg kg (-1) min (-1)) before and after a complete neuromuscular blockade produced by intravenous injection of 0.6 mg kg (-1) Rocuronium.The P (leak) decreased by more than 10 % of the baseline P (leak) in 8 out of 73 patients (11 %); however, in the entire study population there was no significant difference between the mean baseline P (leak) (28.5 +/- 7.3 cm H(2)O) and the mean P (leak) after complete neuromuscular blockade (29.1 +/- 7.0 cm H(2)O); (p = 0.128).No general correlation between application of a neuromuscular blocking agent and a decrease of the mean P (leak) was found. However, the decrease of the P (leak) by more than 10 % in 11 % of the patients shows that in certain patients the application of neuromuscular blocking agents can result in a decreased P (leak) of the PLMA and indicates the necessity to control the P (leak) of the PLMA under complete muscle paralysis preoperatively when neuromuscular blocking agents are used.
Published: 2006

31. [Anaesthesia education at german university hospitals: the teachers' perspective -- results of a nationwide survey]

Author: K, Goldmann, T, Steinfeldt, and H, Wulf
Subjects: Anesthesiology, Data Collection, Germany, Surveys and Questionnaires, Teaching, Internship and Residency, Workload, Hospitals, Teaching
Abstract: The principle purpose of this study was to collect data on the conditions and practice of anaesthesia education as well as the teaching qualification of consultants at German university hospitals. Based upon the collected data, areas of weakness and strength as well as measures required to improve anaesthesia training are described.A questionnaire containing 26 items was mailed to 607 consultants employed at 41 German university hospitals in June 2003.A total of 255 questionnaires was analysed (response rate: 43 %). Genuine training activities account for 14 % of the working hours of the participating consultants. On average, at the institutions of participating consultants, novices work for a duration of 1 month together with a consultant anaesthetist before they give anaesthetics without direct and constant supervision. When asked to describe the predominant method of training at their institution 71 % indicated "case-oriented teaching"; however, 53 % chose "see one, do one, teach one" and 49 % "learning by doing" as method of training as well (multiple choice). According to 63 % of respondents, departmental educational activities usually happen after their regular working hours. "Daily workload" (96 %), "time pressure" (96 %), "lack of time" (96 %) and "lack of personnel" (90 %) were indicated as the main obstacles of teaching. According to 80 % of respondents, a dedicated financial budget for education does not exist; instead, financial resources of third parties (industry) (58 %), of the state (for research und undergraduate education) (60 %) and of patients service (66 %) are used to ensure training of anaesthesia residents.Due to a lack of a dedicated financial budget for resident training and an increasing economic pressure, "lack of time" and "lack of personnel" are the main factors leading to the situation at German university hospitals that consultants can only spend 14 % of their working hours for teaching purposes despite of sufficient qualification and motivation. As a consequence, novice anaesthetists are faced with the situation to be working without direct and constant supervision after 1 month of training.
Published: 2006

32. 1 molares Gadobutrol als alternatives Kontrastmittel für die Computertomographie – Evaluierung von Nierenfunktionsparametern in einer tierexperimentellen Studie im Schwein

Author: Martin Gotthardt, Klaus-Jochen Klose, K Goldmann, Hans-Joachim Wagner, and M. K. Kalinowski
Subjects: Radiology, Nuclear Medicine and imaging
Published: 2006
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33. [Use of the size 3 ProSeal laryngeal mask airway in children. Results of a randomized crossover investigation with the Classic laryngeal mask airway]

Author: K, Goldmann, C, Roettger, and H, Wulf
Subjects: Male, Air Pressure, Cross-Over Studies, Adolescent, Laryngoscopy, Stomach, Insufflation, Respiration, Artificial, Laryngeal Masks, Tidal Volume, Fiber Optic Technology, Humans, Female, Anesthesia, Inhalation, Child, Intubation, Gastrointestinal
Abstract: The low-pressure airway seal of the Classic laryngeal mask airway (CLMA) can be inadequate for positive pressure ventilation (PPV) in children. The ProSeal laryngeal mask airway (PLMA) forms a more effective seal of the airway than the CLMA and facilitates gastric tube placement in adults. The size 3 PLMA can be used in adults and children.The CLMA and PLMA were studied in random order -- crossover -- in 30 anaesthetized, non-paralysed children (average age 10.6 years, average body weight 39 kg). Airway leak pressure, maximum tidal volume, ease of insertion, quality of initial airway and fiberoptic position were determined. Gastric tube placement was assessed for the PLMA.The mean airway leak pressure in neutral head position (27.0 vs. 16.8 cm H(2)O), maximum flexion (38.3 vs. 26.2 cm H(2)O) and maximum extension (21.1 vs. 14.2 cm H(2)O) as well as the mean maximum tidal volume (1432 vs. 1062 ml) were significantly higher (p0.001) for the PLMA. Air insufflation into the stomach occurred with the CLMA but not with the PLMA. Gastric tube placement was possible in all patients.The high reliability of g-tube placement and the significantly increased airway leak pressure seem to make the size 3 PLMA a more suitable device for PPV in children than the same size CLMA.
Published: 2005

34. [Use of the laryngeal mask airway at german university and university-affiliated hospitals -- results of a nationwide survey]

Author: K, Goldmann and U, Braun
Subjects: Hospitals, University, Data Collection, Germany, Surveys and Questionnaires, Respiration, Artificial, Laryngeal Masks
Abstract: The aim of this study was to collect comprehensive data on the use of the laryngeal mask airway (LMA) under general anaesthesia at German university and university-affiliated hospitals.Questionnaires were mailed to the directors of 452 German university and university-affiliated anaesthesia departments. Twenty-three questions related to the way and frequency of use of the LMA were asked.Data from 212 departments (47 %) could be included into the analysis. The LMA is used in all departments. Depending on the size of the department the LMA is used in 1 - 60 % of all anaesthetics. The LMA is used significantly more often (p0.001) in smaller departments providing up to 10 000 anaesthetics per year compared to larger departments providing up to, or more than, 20 000 anaesthetics per year. Controlled ventilation is the preferred mode of ventilation in more than 75 % of all departments. The LMA is used "routinely" or "always" for operations lasting more than 1 hour in more than 75 % of all departments. The LMA is used in the areas of ear, nose, and throat, maxillofacial, and eye surgery "routinely" or "always" only in 11 - 26 % of all departments.The role of the LMA in routine anaesthesia practice has clearly increased. Controversial aspects of use are reflected in the practice patterns of LMA use in different departments. The LMA has not been disseminated widely in the areas of ear, nose and throat-, maxillofacial- and eye surgery.
Published: 2005

35. Measurement of Dijet Azimuthal Decorrelations at Central Rapidities inpp¯Collisions ats=1.96 TeV

Author: Karel Smolek, Marvin Johnson, M. Warsinsky, Adam L. Lyon, H. Dong, D. Buchholz, G. Bernardi, Emanuela Barberis, A. V. Kozelov, S. E.K. Mattingly, D. Skow, P. Tamburello, D. Fein, D. Chakraborty, Kazunori Hanagaki, Dongliang Zhang, Cris W. Barnes, Charles Leggett, Florian Beaudette, Anna Goussiou, L. Christofek, M. Anastasoaie, Arnulf Quadt, J. Dyer, D. Chapin, Elemer Nagy, Y. Jiang, B. Connolly, M. C. Cousinou, Gregory R Snow, Vivek Jain, Q. Xu, Don Lincoln, Erich Varnes, P. W. Balm, Jonas Strandberg, N. Parua, M. Eads, M. Jaffré, Tulika Bose, M. Verzocchi, D. A. Stoyanova, A. S. Turcot, J. N. Butler, P. D. Grannis, J. Steele, P.F. Ermolov, S. Fu, B. Thooris, M. Strovink, Guennadi Borissov, G. Alkhazov, Thomas Trefzger, B. Clément, H. Haggerty, W. C. Fisher, L. S. Vertogradov, Michael Martens, Paul Telford, C. Hebert, Arnaud Lucotte, Yu-tin Huang, R. Bernhard, D. A. Wijngaarden, G. Hesketh, J. Kasper, Markus Klute, Neeti Parashar, Alexander Kupco, Sung Keun Park, L. Lobo, Lorenzo Feligioni, T. C. Bacon, Robert Harrington, A. Leflat, G. D. Alexeev, Flera Rizatdinova, C. Noeding, R. Zitoun, Alexander Khanov, F. Fleuret, M. Zielinski, Nikos Varelas, Bing Zhou, Randy Ruchti, L. Lueking, D. K. Cho, Zhenbin Wu, S. N. Fatakia, Jaebeom Park, V. M. Podstavkov, Wendy Taylor, Michael Begel, K. Bos, Marc Besancon, J. Temple, O. Kouznetsov, M. A. Strang, S. N. Ahmed, M. Fortner, N. W. Reay, M. Kopal, Y. Arnoud, Andrew White, Jing Li, E. Popkov, R. L. McCarthy, Heriberto Castilla-Valdez, B. Olivier, S. Söldner-Rembold, Y. Hu, Ph Gris, S. Tentindo-Repond, Emmanuel Busato, J. Zhu, K. Del Signore, C. Han, P. K. Mal, W. E. Cooper, J. M. Hauptman, Cecilia Elena Gerber, M. P. Sanders, G. Ginther, Eduardo De Moraes Gregores, G. A. Davis, Boris Tuchming, P. Houben, D. Mihalcea, Christian Schmitt, S. Nelson, M. H.G. Souza, C. De Oliveira Martins, P. N. Ratoff, Jianming Qian, Andrei Nomerotski, J. F. Renardy, Philip Baringer, Arnaud Duperrin, S. Jabeen, Graham Wilson, H. da Motta, John Hobbs, A. Magerkurth, G. Briskin, H. Weerts, Z. M. Wang, V. M. Korablev, S. Banerjee, R. Gelhaus, H. E. Montgomery, P. M. Tuts, V. E. Kuznetsov, M. Binder, Michael A. Strauss, A. Zatserklyaniy, Jong-Sung Yu, A. S. Ito, A. Melnitchouk, P. Lebrun, J. Fast, M. Buehler, Sergey Burdin, A. Baden, Jeffrey F. Krane, M. Doidge, J. Barreto, C. Boswell, O. Boeriu, Robert Hirosky, S. Baffioni, G. C. Blazey, Y. Yen, B. Zhang, B. S. Acharya, Y. Kulik, A. Stone, S. P. Denisov, V. V. Lipaev, N. R. Stanton, Tobias Golling, T. Scanlon, A. M. Kalinin, R. Yamada, S. Kermiche, Suman Bala Beri, Daniel Whiteson, Jean-Francois Grivaz, Vivian O'Dell, S. H. Ahn, S. Sengupta, P. de Jong, A. Juste, P. Bonamy, Todd Adams, Jovan Mitrevski, G. Gutierrez, M. R. Krishnaswamy, Gilvan Alves, S. Beauceron, Nikola Makovec, P. Jonsson, V. S. Narasimham, L. Groer, Thomas G Trippe, W. Kahl, Karl Jakobs, Thomas Hebbeker, M. Mulders, M. Sosebee, L. Han, C. Luo, Mary Beth Adams, P. Mättig, A. A. Mayorov, Z. Ke, R. Illingworth, T. Vu Anh, E. De La Cruz-Burelo, A. C. Le Bihan, S. J. De Jong, James C. Green, P. Lewis, J. Snow, M. Zdrazil, D. Edmunds, Andrew Brandt, U. Bassler, F. Borcherding, B. Kothari, W. D. Shephard, Shuichi Kunori, D. R. Claes, H.E. Miettinen, Carsten Hensel, G. Sajot, Gavin Davies, R. McCroskey, Andre Sznajder, Regina Demina, J. Coss, Yuri Gershtein, Emmanuelle Perez, S. Doulas, S. W. Youn, E. Von Toerne, Y. Coadou, P. Demine, H. Zheng, K. Goldmann, Miguel Mostafa, Dugan O'Neil, E. G. Zverev, L. Babukhadia, A. Patwa, Kaushik De, D. Coppage, Denis Gelé, A. Cothenet, N. M. Cason, Reinhard Schwienhorst, Sarah Catherine Eno, Horst Severini, I. Blackler, David Colling, L. Phaf, Alberto Santoro, J. G.R. Lima, Frank Fiedler, F. Nang, Norbert Wermes, Meenakshi Narain, Sherry Towers, Jan Stark, Richard B. Lipton, E. Kajfasz, Kristian Harder, Pushpalatha C Bhat, A. A. Schukin, T. Edwards, C. Miao, Lev Uvarov, P. Hanlet, A. Meyer, F. Badaud, N. A. Naumann, D. Cutts, Henry Lubatti, A. Sanchez-Hernandez, J. Lu, J. Lazoflores, S. Reucroft, Marcel Vreeswijk, Wagner Carvalho, B. Spurlock, Zeno Dixon Greenwood, V. Zutshi, Seo Won Lee, Reiner Hauser, D. Käfer, A. Bellavance, Frederic Deliot, Emily Nurse, Greg Landsberg, Elizabeth Gallas, T. McMahon, P. Rubinov, Marumi Kado, Christopher George Tully, M. Cooke, W. L. Prado Da Silva, S. Chopra, M. A.C. Cummings, A. Yurkewicz, Pedrame Bargassa, K. Soustruznik, N. J. Buchanan, B. Vachon, B. Hoeneisen, Lee Sawyer, Cristina Galea, Xiuping Li, Y. M. Kharzheev, H. E. Fisk, Ariel Schwartzman, M. Abolins, Patrick Slattery, Johannes Elmsheuser, Andrew Askew, Zhengguo Zhao, M. Lynker, Melissa Ridel, J. T. Eltzroth, P. Neustroev, G. J. Otero y Garzón, Kevin Black, D. Shpakov, Q. Z. Li, N. K. Mondal, P. Schieferdecker, H. T. Diehl, T. A. Bolton, R. Kehoe, Y. Pogorelov, R. Jesik, X. F. Song, A. Boehnlein, Z. Zhou, K. A. Johns, J. Ellison, A. K.A. Maciel, Sa. Jain, S. Fuess, T. Kurca, Marc Weber, A. Lounis, Aran Garcia-Bellido, S. Krzywdzinski, R. Hooper, S.A. Kahn, J. A. Parsons, Sebastian Grinstein, M. Hohlfeld, M. Gao, A. Zylberstejn, M. Demarteau, Raimund Ströhmer, V. Simak, V. Oguri, A. Koubarovsky, F. Lehner, Carmen García, R. Van Kooten, P. Padley, B. G. Pope, H. Greenlee, J. Hays, Gustaaf Brooijmans, Mitchell Wayne, H. Schellman, J. M. Kohli, B. C.K. Casey, M. D. Corcoran, Stefan Grünendahl, S. R. Hou, A. Bross, J. Warchol, Mossadek Talby, B. Gómez, Shashikant Dugad, Serban Protopopescu, K. W. Merritt, F. Blekman, J. Bystricky, G. Graham, A. Zieminski, Kyoung-Ho Kim, Andy Haas, L. Duflot, J. F. Bartlett, V. Manankov, Elizaveta Shabalina, N.V. Mokhov, B. Åsman, F. Charles, M. Agelou, M. I. Martin, S. Greder, A. P. Heinson, T. Nunnemann, B. Baldin, M. Yan, J. Huang, G. S. Muanza, M. Merkin, R. E. Hall, Christophe Royon, R. A. Sidwell, W. M. Lee, A. Kharchilava, Andre Sopczak, Sergey Kuleshov, V. Buescher, Elliott Cheu, Victor Daniel Elvira, P. A. Rapidis, D. Evans, H. D. Wahl, D. Bauer, O. Peters, A. Jonckheere, E. Galyaev, S. Dean, Stephan Linn, A. Lobodenko, T. Yasuda, N. Oshima, Daniel Bloch, Tiefu Zhao, Daria Zieminska, R. D. Schamberger, Raymond Brock, Boaz Klima, N. Wallace, T. R. Wyatt, G. Steinbrück, T. H. Burnett, T. Wlodek, K. Genser, M. A. Kubantsev, Ulrike Blumenschein, R. Beuselinck, Ulrich Heintz, H. Jöstlein, P. L.M. Podesta-Lerma, Frank Filthaut, M. Diesburg, Jean-Laurent Agram, Brad Abbott, Christos Leonidopoulos, Pierre Petroff, J. Womersley, J. Wittlin, M. Wobisch, D. Karmanov, Sudhir Malik, Ia Iashvili, Jean-Roch Vlimant, Rodney Walker, Alexandre Zabi, P. Verdier, A. Evdokimov, M. Petteni, Suyong Choi, B. Davies, L. Sonnenschein, A. Jenkins, B. M. Sabirov, M. Bhattacharjee, A. M. Magnan, P. Skubic, A. Besson, T. Toole, Pierre-Antoine Delsart, S. Lager, Sharon Hagopian, S. Uvarov, K. Papageorgiou, Sergio F Novaes, H. L. Melanson, M. Wegner, Yurii Maravin, Vladimir Gavrilov, Gordon Watts, V. Sirotenko, M. Cristetiu, O. V. Eroshin, Y. Song, B. Quinn, Phillip Gutierrez, D. Denisov, Makoto Tomoto, David H. Adams, V. M. Abazov, V. Shary, Alice Bean, J. Torborg, T. Christiansen, H. A. Neal, Laurent Chevalier, J. M. Heinmiller, Hal Evans, Thomas Ferbel, Stephen Wimpenny, P. Johnson, D. Meder, R. Piegaia, J. T. Linnemann, Martin Grunewald, A. R. Clark, F. Canelli, N. Oliveira, V. Sorín, K. Yip, N. Xuan, V. White, T. Marshall, Milos Lokajicek, Iain Alexander Bertram, Michael Rijssenbeek, Darien Wood, L. Stutte, A.S. Dyshkant, Nicholas John Hadley, S. Blessing, Scott Snyder, D. Wicke, V. N. Evdokimov, I. Ripp-Baudot, I. Hall, A. Chandra, S. Chakrabarti, W. Gu, F. Villeneuve-Seguier, R. J. Madaras, Christophe Clement, M. B. Przybycien, J. Gardner, K. J. Rani, George Alverson, D. Casey, Walter Freeman, J. Kotcher, S. Anderson, A. Alton, Harald Fox, D. Hedin, S. N. Gurzhiev, M. Vaupel, B. Andrieu, S. Kesisoglou, Chris Hays, R. W. Moore, Viatcheslav Stolin, Manas Maity, J. Molina, Carlos Avila, S. Sumowidagdo, Sabine Crépé-Renaudin, V. A. Bezzubov, J. P. Negret, R. P. Smith, Sophie Trincaz-Duvoid, J. Kozminski, Michael Hildreth, D. Kau, Y. D. Mutaf, I. A. Vasilyev, P. M. Perea, Vipin Bhatnagar, K. Stevenson, S. Uzunyan, Y. A. Yatsunenko, K. M. Chan, Christian Zeitnitz, N. Lahrichi, R. Partridge, X. Zhang, A. V. Kotwal, Harrison Prosper, S. Desai, S. J. Hong, Christian Autermann, V. L. Malyshev, J. Rha, H. S. Mao, A. Bischoff, E. Thomas, K. Gounder, J. R. Kalk, O. Atramentov, G. Geurkov, L. Coney, G. Savage, X. Meng, Juan Estrada, and W. M. Van Leeuwen
Subjects: Physics, Quantum chromodynamics, Particle physics, Luminosity (scattering theory), 010308 nuclear & particles physics, General Physics and Astronomy, Perturbative QCD, 01 natural sciences, Azimuth, Momentum, Nuclear physics, Transverse plane, 0103 physical sciences, High Energy Physics::Experiment, Rapidity, Nuclear Experiment, 010306 general physics, Event (particle physics)
Abstract: Correlations in the azimuthal angle between the two largest transverse momentum jets have been measured using the D0 detector in p (p) over bar collisions at a center-of-mass energy root s=1.96 TeV. The analysis is based on an inclusive dijet event sample in the central rapidity region corresponding to an integrated luminosity of 150 pb(-1). Azimuthal correlations are stronger at larger transverse momenta. These are well described in perturbative QCD at next-to-leading order in the strong coupling constant, except at large azimuthal differences where contributions with low transverse momentum are significant.
Published: 2005
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36. Measurement of dijet azimuthal decorrelations at central rapidities in pp collisions at sqrt s =1.96 TeV

Author: V M, Abazov, B, Abbott, M, Abolins, B S, Acharya, D L, Adams, M, Adams, T, Adams, M, Agelou, J-L, Agram, S N, Ahmed, S H, Ahn, G D, Alexeev, G, Alkhazov, A, Alton, G, Alverson, G A, Alves, M, Anastasoaie, S, Anderson, B, Andrieu, Y, Arnoud, A, Askew, B, Asman, O, Atramentov, C, Autermann, C, Avila, L, Babukhadia, T C, Bacon, F, Badaud, A, Baden, S, Baffioni, B, Baldin, P W, Balm, S, Banerjee, E, Barberis, P, Bargassa, P, Baringer, C, Barnes, J, Barreto, J F, Bartlett, U, Bassler, D, Bauer, A, Bean, S, Beauceron, F, Beaudette, M, Begel, A, Bellavance, S B, Beri, G, Bernardi, R, Bernhard, I, Bertram, M, Besançon, A, Besson, R, Beuselinck, V A, Bezzubov, P C, Bhat, V, Bhatnagar, M, Bhattacharjee, M, Binder, A, Bischoff, K M, Black, I, Blackler, G, Blazey, F, Blekman, S, Blessing, D, Bloch, U, Blumenschein, A, Boehnlein, O, Boeriu, T A, Bolton, P, Bonamy, F, Borcherding, G, Borissov, K, Bos, T, Bose, C, Boswell, A, Brandt, G, Briskin, R, Brock, G, Brooijmans, A, Bross, N J, Buchanan, D, Buchholz, M, Buehler, V, Buescher, S, Burdin, T H, Burnett, E, Busato, J M, Butler, J, Bystricky, F, Canelli, W, Carvalho, B C K, Casey, D, Casey, N M, Cason, H, Castilla-Valdez, S, Chakrabarti, D, Chakraborty, K M, Chan, A, Chandra, D, Chapin, F, Charles, E, Cheu, L, Chevalier, D K, Cho, S, Choi, S, Chopra, T, Christiansen, L, Christofek, D, Claes, A R, Clark, B, Clément, C, Clément, Y, Coadou, D J, Colling, L, Coney, B, Connolly, M, Cooke, W E, Cooper, D, Coppage, M, Corcoran, J, Coss, A, Cothenet, M-C, Cousinou, S, Crépé-Renaudin, M, Cristetiu, M A C, Cummings, D, Cutts, H, da Motta, B, Davies, G, Davies, G A, Davis, K, De, P, de Jong, S J, de Jong, E, De La Cruz-Burelo, C De Oliveira, Martins, S, Dean, K, Del Signore, F, Déliot, P A, Delsart, M, Demarteau, R, Demina, P, Demine, D, Denisov, S P, Denisov, S, Desai, H T, Diehl, M, Diesburg, M, Doidge, H, Dong, S, Doulas, L, Duflot, S R, Dugad, A, Duperrin, J, Dyer, A, Dyshkant, M, Eads, D, Edmunds, T, Edwards, J, Ellison, J, Elmsheuser, J T, Eltzroth, V D, Elvira, S, Eno, P, Ermolov, O V, Eroshin, J, Estrada, D, Evans, H, Evans, A, Evdokimov, V N, Evdokimov, J, Fast, S N, Fatakia, D, Fein, L, Feligioni, T, Ferbel, F, Fiedler, F, Filthaut, W, Fisher, H E, Fisk, F, Fleuret, M, Fortner, H, Fox, W, Freeman, S, Fu, S, Fuess, C F, Galea, E, Gallas, E, Galyaev, M, Gao, C, Garcia, A, Garcia-Bellido, J, Gardner, V, Gavrilov, P, Gay, D, Gelé, R, Gelhaus, K, Genser, C E, Gerber, Y, Gershtein, G, Geurkov, G, Ginther, K, Goldmann, T, Golling, B, Gómez, K, Gounder, A, Goussiou, G, Graham, P D, Grannis, S, Greder, J A, Green, H, Greenlee, Z D, Greenwood, E M, Gregores, S, Grinstein, Ph, Gris, J-F, Grivaz, L, Groer, S, Grünendahl, M W, Grünewald, W, Gu, S N, Gurzhiev, G, Gutierrez, P, Gutierrez, A, Haas, N J, Hadley, H, Haggerty, S, Hagopian, I, Hall, R E, Hall, C, Han, L, Han, K, Hanagaki, P, Hanlet, K, Harder, R, Harrington, J M, Hauptman, R, Hauser, C, Hays, J, Hays, T, Hebbeker, C, Hebert, D, Hedin, J M, Heinmiller, A P, Heinson, U, Heintz, C, Hensel, G, Hesketh, M D, Hildreth, R, Hirosky, J D, Hobbs, B, Hoeneisen, M, Hohlfeld, S J, Hong, R, Hooper, S, Hou, P, Houben, Y, Hu, J, Huang, Y, Huang, I, Iashvili, R, Illingworth, A S, Ito, S, Jabeen, M, Jaffré, S, Jain, V, Jain, K, Jakobs, A, Jenkins, R, Jesik, Y, Jiang, K, Johns, M, Johnson, P, Johnson, A, Jonckheere, P, Jonsson, H, Jöstlein, A, Juste, M M, Kado, D, Käfer, W, Kahl, S, Kahn, E, Kajfasz, A M, Kalinin, J, Kalk, D, Karmanov, J, Kasper, D, Kau, Z, Ke, R, Kehoe, S, Kermiche, S, Kesisoglou, A, Khanov, A, Kharchilava, Y M, Kharzheev, K H, Kim, B, Klima, M, Klute, J M, Kohli, M, Kopal, V M, Korablev, J, Kotcher, B, Kothari, A V, Kotwal, A, Koubarovsky, O, Kouznetsov, A V, Kozelov, J, Kozminski, J, Krane, M R, Krishnaswamy, S, Krzywdzinski, M, Kubantsev, S, Kuleshov, Y, Kulik, S, Kunori, A, Kupco, T, Kurca, V E, Kuznetsov, S, Lager, N, Lahrichi, G, Landsberg, J, Lazoflores, A-C, Le Bihan, P, Lebrun, S W, Lee, W M, Lee, A, Leflat, C, Leggett, F, Lehner, C, Leonidopoulos, P, Lewis, J, Li, Q Z, Li, X, Li, J G R, Lima, D, Lincoln, S L, Linn, J, Linnemann, V V, Lipaev, R, Lipton, L, Lobo, A, Lobodenko, M, Lokajicek, A, Lounis, J, Lu, H J, Lubatti, A, Lucotte, L, Lueking, C, Luo, M, Lynker, A L, Lyon, A K A, Maciel, R J, Madaras, P, Mättig, A, Magerkurth, A-M, Magnan, M, Maity, N, Makovec, P K, Mal, S, Malik, V L, Malyshev, V, Manankov, H S, Mao, Y, Maravin, T, Marshall, M, Martens, M I, Martin, S E K, Mattingly, A A, Mayorov, R, McCarthy, R, McCroskey, T, McMahon, D, Meder, H L, Melanson, A, Melnitchouk, X, Meng, M, Merkin, K W, Merritt, A, Meyer, C, Miao, H, Miettinen, D, Mihalcea, J, Mitrevski, N, Mokhov, J, Molina, N K, Mondal, H E, Montgomery, R W, Moore, M, Mostafa, G S, Muanza, M, Mulders, Y D, Mutaf, E, Nagy, F, Nang, M, Narain, V S, Narasimham, N A, Naumann, H A, Neal, J P, Negret, S, Nelson, P, Neustroev, C, Noeding, A, Nomerotski, S F, Novaes, T, Nunnemann, E, Nurse, V, O'Dell, D C, O'Neil, V, Oguri, N, Oliveira, B, Olivier, N, Oshima, G J, Otero y Garzón, P, Padley, K, Papageorgiou, N, Parashar, J, Park, S K, Park, J, Parsons, R, Partridge, N, Parua, A, Patwa, P M, Perea, E, Perez, O, Peters, P, Pétroff, M, Petteni, L, Phaf, R, Piegaia, P L M, Podesta-Lerma, V M, Podstavkov, Y, Pogorelov, B G, Pope, E, Popkov, W L, Prado da Silva, H B, Prosper, S, Protopopescu, M B, Przybycien, J, Qian, A, Quadt, B, Quinn, K J, Rani, P A, Rapidis, P N, Ratoff, N W, Reay, J-F, Renardy, S, Reucroft, J, Rha, M, Ridel, M, Rijssenbeek, I, Ripp-Baudot, F, Rizatdinova, C, Royon, P, Rubinov, R, Ruchti, B M, Sabirov, G, Sajot, A, Sánchez-Hernández, M P, Sanders, A, Santoro, G, Savage, L, Sawyer, T, Scanlon, R D, Schamberger, H, Schellman, P, Schieferdecker, C, Schmitt, A A, Schukin, A, Schwartzman, R, Schwienhorst, S, Sengupta, H, Severini, E, Shabalina, V, Shary, W D, Shephard, D, Shpakov, R A, Sidwell, V, Simak, V, Sirotenko, D, Skow, P, Skubic, P, Slattery, R P, Smith, K, Smolek, G R, Snow, J, Snow, S, Snyder, S, Söldner-Rembold, X, Song, Y, Song, L, Sonnenschein, A, Sopczak, V, Sorín, M, Sosebee, K, Soustruznik, M, Souza, B, Spurlock, N R, Stanton, J, Stark, J, Steele, G, Steinbrück, K, Stevenson, V, Stolin, A, Stone, D A, Stoyanova, J, Strandberg, M A, Strang, M, Strauss, R, Ströhmer, M, Strovink, L, Stutte, S, Sumowidagdo, A, Sznajder, M, Talby, P, Tamburello, W, Taylor, P, Telford, J, Temple, S, Tentindo-Repond, E, Thomas, B, Thooris, M, Tomoto, T, Toole, J, Torborg, S, Towers, T, Trefzger, S, Trincaz-Duvoid, T G, Trippe, B, Tuchming, C, Tully, A S, Turcot, P M, Tuts, L, Uvarov, S, Uvarov, S, Uzunyan, B, Vachon, R, Van Kooten, W M, van Leeuwen, N, Varelas, E W, Varnes, I A, Vasilyev, M, Vaupel, P, Verdier, L S, Vertogradov, M, Verzocchi, F, Villeneuve-Seguier, J-R, Vlimant, E, Von Toerne, M, Vreeswijk, T, Vu Anh, H D, Wahl, R, Walker, N, Wallace, Z-M, Wang, J, Warchol, M, Warsinsky, G, Watts, M, Wayne, M, Weber, H, Weerts, M, Wegner, N, Wermes, A, White, V, White, D, Whiteson, D, Wicke, D A, Wijngaarden, G W, Wilson, S J, Wimpenny, J, Wittlin, T, Wlodek, M, Wobisch, J, Womersley, D R, Wood, Z, Wu, T R, Wyatt, Q, Xu, N, Xuan, R, Yamada, M, Yan, T, Yasuda, Y A, Yatsunenko, Y, Yen, K, Yip, S W, Youn, J, Yu, A, Yurkewicz, A, Zabi, A, Zatserklyaniy, M, Zdrazil, C, Zeitnitz, B, Zhang, D, Zhang, X, Zhang, T, Zhao, Z, Zhao, H, Zheng, B, Zhou, Z, Zhou, J, Zhu, M, Zielinski, D, Zieminska, A, Zieminski, R, Zitoun, V, Zutshi, E G, Zverev, and A, Zylberstejn
Subjects: High Energy Physics::Experiment, Nuclear Experiment
Abstract: Correlations in the azimuthal angle between the two largest transverse momentum jets have been measured using the D0 detector in p (-)p collisions at a center-of-mass energy sqrt[s]=1.96 TeV. The analysis is based on an inclusive dijet event sample in the central rapidity region corresponding to an integrated luminosity of 150 pb(-1). Azimuthal correlations are stronger at larger transverse momenta. These are well described in perturbative QCD at next-to-leading order in the strong coupling constant, except at large azimuthal differences where contributions with low transverse momentum are significant.
Published: 2005

37. Measurement of theBs0Lifetime in the Exclusive Decay ChannelBs0→J/ψϕ

Author: V. White, S. N. Gurzhiev, Y. A. Yatsunenko, B. Andrieu, Viatcheslav Stolin, Manas Maity, J. Molina, Carlos Avila, S. Sumowidagdo, Sabine Crépé-Renaudin, Raimund Ströhmer, Michael A. Strauss, F. Villeneuve-Seguier, V. Simak, J. M. Hauptman, Cecilia Elena Gerber, T. H. Burnett, Karel Smolek, P. Lebrun, C. Boswell, O. Boeriu, D. Fein, D. Chakraborty, H. Dong, Christophe Royon, D. R. Claes, W. M. Van Leeuwen, Y. Kulik, W. Gu, L. S. Vertogradov, P. Padley, F. Borcherding, Sung Keun Park, S. E.K. Mattingly, S. W. Youn, E. Von Toerne, P. Demine, G. Ginther, Jianming Qian, M. Abolins, Gavin Davies, V. M. Abazov, V. Shary, J. Torborg, D. Buchholz, Mitchell Wayne, H. Schellman, J. M. Kohli, H. Zheng, G. Sajot, B. M. Sabirov, H. D. Wahl, Ulrich Heintz, Pushpalatha C Bhat, Reiner Hauser, K. J. Rani, A. Alton, G. Bernardi, Emanuela Barberis, Kazunori Hanagaki, Dongliang Zhang, S. Greder, Dugan O'Neil, A. Stone, Tobias Golling, T. Scanlon, Emily Nurse, Elizabeth Gallas, T. McMahon, A. Leflat, S. Kermiche, Y. Hu, D. Bauer, Don Lincoln, Erich Varnes, Stefan Grünendahl, Cris W. Barnes, Iain Alexander Bertram, Michael Rijssenbeek, S. R. Hou, Mossadek Talby, B. Gómez, B. Tuchming, Frank Filthaut, A. Patwa, L. Lueking, Suman Bala Beri, F. Badaud, P. W. Balm, G. Alkhazov, S. Doulas, R. W. Moore, M. Diesburg, Vivek Jain, S. J. Hong, G. Briskin, D. Coppage, Kevin Black, T. Christiansen, H. A. Neal, D. Meder, V. Sorín, K. Yip, N. Xuan, H. Jostlein, Vivian O'Dell, D. K. Cho, Y. Arnoud, M. Kopal, Markus Klute, M. Cooke, Denis Gelé, N. M. Cason, F. Blekman, Charles Leggett, C. Hebert, Miguel Mostafa, M. A.C. Cummings, E. Galyaev, B. Hoeneisen, Kaushik De, A. Juste, P. Bonamy, Jean-Francois Grivaz, N. K. Mondal, Paul Telford, David Colling, L. Stutte, D. Skow, P. Schieferdecker, P. Tamburello, Todd Adams, Florian Beaudette, W. L. Prado Da Silva, H. T. Diehl, T. A. Bolton, S. Chopra, Lee Sawyer, A.S. Dyshkant, D. Wicke, B. Vachon, Sarah Catherine Eno, Horst Severini, Marvin Johnson, A. L. Lyon, M. Warsinsky, S. Tentindo-Repond, S. R. Dugad, K. M. Chan, Christian Zeitnitz, E. Popkov, P. K. Mal, Anna Goussiou, J. Gardner, V. N. Evdokimov, A. V. Kozelov, Y. Pogorelov, F. Charles, F. Nang, I. Hall, J. Krane, W. E. Cooper, K. Del Signore, A. Yurkewicz, Alexander Khanov, M. Doidge, F. Fleuret, T. Yasuda, L. Christofek, A. Chandra, J. T. Linnemann, B. Davies, M. Anastasoaie, I. Blackler, Richard B. Lipton, Emmanuel Busato, A. Baden, L. Sonnenschein, A. Boehnlein, J. Zhu, L. Phaf, R. Van Kooten, Norbert Wermes, Meenakshi Narain, Sherry Towers, D. Chapin, Heriberto Castilla-Valdez, Q. Z. Li, Johannes Elmsheuser, G. C. Blazey, Y. Yen, B. Zhang, D. Edmunds, N. A. Naumann, X. T. Meng, R. L. McCarthy, A. Besson, C. Han, M. D. Corcoran, J. T. Eltzroth, S. Chakrabarti, R. Yamada, Tulika Bose, J. Dyer, S. Baffioni, Christos Leonidopoulos, D. Casey, Walter Freeman, J. Kotcher, Philip Baringer, J. A. Parsons, W. D. Shephard, Pierre-Antoine Delsart, Z. Zhao, Jan Stark, M. Verzocchi, Frederic Deliot, Gregory R Snow, Sebastian Grinstein, S. H. Ahn, J. Ellison, P. de Jong, S. Reucroft, D. Mihalcea, Arnaud Duperrin, Ariel Schwartzman, Christopher George Tully, A. K.A. Maciel, S. Jabeen, S.A. Kahn, R. Jesik, Sergey Burdin, J. Womersley, Sharon Hagopian, R. McCroskey, Andre Sznajder, K. Papageorgiou, M. Strovink, Henry Lubatti, Arnulf Quadt, S. Anderson, P. Jonsson, Thomas Hebbeker, M. Mulders, L. Han, C. De Oliveira Martins, P. N. Ratoff, A. Bischoff, V. M. Korablev, G. Graham, A. Zieminski, J. N. Butler, S. Banerjee, Sa. Jain, P. D. Grannis, S. P. Denisov, Yuri Gershtein, Seo Won Lee, D. Käfer, J. Wittlin, A. Bellavance, S. Fuess, Emmanuelle Perez, M. Wobisch, Michael Martens, C. Luo, K. Gounder, J. R. Kalk, Jong-Sung Yu, B. Olivier, S. Söldner-Rembold, P. M. Tuts, J. Lazoflores, M. Lynker, M. Demarteau, J. Fast, Harald Fox, O. Atramentov, M. R. Krishnaswamy, G. Geurkov, D. Karmanov, Q. Xu, V. E. Kuznetsov, T. Kurca, X. F. Song, J. Huang, P. A. Rapidis, Y. M. Kharzheev, Carmen García, W. Kahl, B. G. Pope, M. Bhattacharjee, C. Noeding, Melissa Ridel, J. Steele, P. Johnson, K. Goldmann, L. Coney, Patrick Slattery, G. J. Otero y Garzón, M. Sosebee, Elemer Nagy, Marc Weber, Sudhir Malik, James C. Green, Kristian Harder, Jing Li, R. Hooper, R. A. Sidwell, E. G. Zverev, Ia Iashvili, U. Bassler, R. Piegaia, Jean-Roch Vlimant, Rodney Walker, G. Savage, Z. Ke, Robert Hirosky, M. Hohlfeld, Wendy Taylor, R. Kehoe, Y. Coadou, Graham Wilson, H. da Motta, D. A. Stoyanova, I. Ripp-Baudot, S. N. Fatakia, Jaebeom Park, V. M. Podstavkov, D. Cutts, A. M. Kalinin, L. Duflot, Wagner Carvalho, M. Vaupel, Reinhard Schwienhorst, A. Meyer, A. S. Turcot, Y. Jiang, M. C. Cousinou, Christian Schmitt, S. Nelson, M. H.G. Souza, Juan Estrada, V. Oguri, S. N. Ahmed, M. Fortner, B. Clement, A. Cothenet, A. Koubarovsky, Y. D. Mutaf, Regina Demina, N. W. Reay, A. Jonckheere, T. C. Bacon, Greg Landsberg, R. Gelhaus, H. E. Montgomery, N.V. Mokhov, Raymond Brock, Yu-tin Huang, J. Hays, M. P. Sanders, S. Dean, Stephan Linn, A. Lobodenko, Tiefu Zhao, J. Kasper, T. Wlodek, I. A. Vasilyev, P. M. Perea, Jovan Mitrevski, J. Bystricky, Elizaveta Shabalina, B. Åsman, Vipin Bhatnagar, M. I. Martin, G. Gutierrez, Boaz Klima, A. S. Ito, A. Melnitchouk, K. W. Merritt, B. Connolly, J. Lu, Gustaaf Brooijmans, T. Vu Anh, E. De La Cruz-Burelo, M. Wegner, S. Fu, M. Zdrazil, L. Babukhadia, K. Genser, Ulrike Blumenschein, Ph Gris, V. Zutshi, P. L.M. Podesta-Lerma, Gilvan Alves, Pedrame Bargassa, Abdenour Lounis, P. Houben, R. Beuselinck, J. F. Bartlett, Nikola Makovec, N. Lahrichi, R. Partridge, X. Zhang, A. P. Heinson, Michael Begel, J. Warchol, G. Steinbrück, V. Manankov, A. Magerkurth, A. Zatserklyaniy, R. Bernhard, N. Oshima, Shuichi Kunori, Jean-Laurent Agram, Daniel Bloch, M. Agelou, Eduardo De Moraes Gregores, Robert Harrington, Alberto Santoro, K. Soustruznik, G. S. Muanza, Nikos Varelas, J. G.R. Lima, Andrew Brandt, N. J. Buchanan, Bing Zhou, L. Lobo, Andrew White, Daniel Whiteson, V. S. Narasimham, K. A. Johns, B. S. Acharya, Laurent Chevalier, D. A. Wijngaarden, Daria Zieminska, A. M. Magnan, L. Groer, Brad Abbott, M. Yan, G. A. Davis, G. Hesketh, R. D. Schamberger, Thomas G Trippe, Karl Jakobs, H. Haggerty, D. Evans, Marcel Vreeswijk, Lorenzo Feligioni, Alexandre Zabi, H.E. Miettinen, Carsten Hensel, S. J. De Jong, Christian Autermann, Stephen Wimpenny, Pierre Petroff, K. Bos, Marc Besancon, J. Temple, P.F. Ermolov, M. Buehler, P. Rubinov, A. A. Mayorov, Andrew Askew, J. F. Renardy, D. Shpakov, R. E. Hall, N. Wallace, P. Verdier, Martin Grunewald, A. R. Clark, B. Spurlock, Zeno Dixon Greenwood, M. A. Kubantsev, V. L. Malyshev, J. Rha, A. Saénchez-Hernaéndez, Terry Richard Wyatt, M. B. Przybycien, V. V. Lipaev, N. R. Stanton, B. Kothari, T. Marshall, Milos Lokajicek, J. Coss, P. Lewis, H. S. Mao, Marumi Kado, E. Thomas, V. Buescher, H. E. Fisk, J. Snow, Christophe Clement, T. Nunnemann, B. Baldin, B. Thooris, Thomas Trefzger, Darien Wood, Z. Zhou, A. Evdokimov, Andrei Nomerotski, S. Beauceron, Nicholas John Hadley, Aran Garcia-Bellido, Frank Fiedler, John Hobbs, E. Kajfasz, M. Petteni, S. Krzywdzinski, S. Blessing, Zhenbin Wu, J. Barreto, T. Toole, P. Mättig, M. R. Adams, W. M. Lee, Scott Snyder, Cristina Galea, A. Kharchilava, M. Merkin, Xiuping Li, M. Gao, R. Illingworth, S. Lager, A. Jenkins, Andre Sopczak, S. Uvarov, Sergey Kuleshov, H. L. Melanson, G. D. Alexeev, Flera Rizatdinova, A. Zylberstejn, P. Skubic, Elliott Cheu, Victor Daniel Elvira, B. Quinn, R. Zitoun, Makoto Tomoto, David H. Adams, Alice Bean, F. Lehner, H. Greenlee, F. Canelli, A. A. Schukin, T. Edwards, N. Oliveira, B. C.K. Casey, C. Miao, A. Bross, O. Peters, Serban Protopopescu, Lev Uvarov, P. Hanlet, Kyoung-Ho Kim, Andy Haas, Suyong Choi, D. Denisov, J. M. Heinmiller, Hal Evans, Thomas Ferbel, Guennadi Borissov, W. C. Fisher, Neeti Parashar, M. Zielinski, M. A. Strang, H. Weerts, Z. M. Wang, O. Kouznetsov, M. Binder, S. Sengupta, Sergio F Novaes, Yurii Maravin, Vladimir Gavrilov, Gordon Watts, V. Sirotenko, A. C. Le Bihan, M. Cristetiu, O. V. Eroshin, Y. Song, Phillip Gutierrez, P. Neustroev, Jonas Strandberg, N. Parua, M. Eads, M. Jaffré, Arnaud Lucotte, Alexander Kupco, Randy Ruchti, R. J. Madaras, George Alverson, D. Hedin, S. Kesisoglou, Chris Hays, V. A. Bezzubov, J. P. Negret, R. P. Smith, Sophie Trincaz-Duvoid, J. Kozminski, Michael Hildreth, D. Kau, K. Stevenson, S. Uzunyan, A. V. Kotwal, Harrison Prosper, and S. Desai
Subjects: Physics, Meson, 010308 nuclear & particles physics, Single measurement, Tevatron, General Physics and Astronomy, 01 natural sciences, Luminosity, law.invention, Nuclear physics, Particle decay, law, 0103 physical sciences, 010306 general physics, Collider
Abstract: Using the exclusive decay B-s(0)-->J/psi(mu(+)mu(-))phi(K+K-), we report the most precise single measurement of the B-s(0) lifetime. The data sample corresponds to an integrated luminosity of approximately 220 pb(-1) collected with the D0 detector at the Fermilab Tevatron Collider in 2002-2004. We reconstruct 337 signal candidates, from which we extract the B-s(0) lifetime, tau(B-s(0))=1.444(-0.090)(+0.098)(stat)+/-0.020(sys) ps. We also report a measurement for the lifetime of the B-0 meson using the exclusive decay B-0-->J/psi(mu(+)mu(-))K-*0(892)(K(+)pi(-)). We reconstruct 1370 signal candidates, obtaining tau(B-0)=1.473(-0.050)(+0.052)(stat)+/-0.023(sys) ps, and the ratio of lifetimes, tau(B-s(0))/tau(B-0)=0.980(-0.071)(+0.076)(stat)+/-0.003(sys).
Published: 2005
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38. Search for supersymmetry with gauge-mediated breaking in diphoton events at D0

Author: A. M. Kalinin, Emily Nurse, U. Bassler, Jovan Mitrevski, G. Gutierrez, Elizabeth Gallas, T. McMahon, A. A. Schukin, Regina Demina, T. Edwards, F. Borcherding, V. S. Narasimham, C. Miao, L. Groer, Thomas G Trippe, Karl Jakobs, G. Sajot, A. A. Mayorov, Lev Uvarov, P. Hanlet, Alberto Santoro, Christian Schmitt, S. Nelson, M. H.G. Souza, B. Vachon, Alexandre Zabi, J. G.R. Lima, Sergey Burdin, S. P. Denisov, Miguel Mostafa, P. Lewis, J. Snow, Christophe Clement, S. Krzywdzinski, P. Rubinov, R. Gelhaus, H. E. Montgomery, M. Abolins, Sarah Catherine Eno, A. Kouchner, J. Kasper, Kevin Black, N. K. Mondal, P. Schieferdecker, H. T. Diehl, T. A. Bolton, A. Boehnlein, J. Ellison, A. K.A. Maciel, Johannes Elmsheuser, J. T. Eltzroth, P. Neustroev, Sa. Jain, R. Jesik, S. Fuess, P. Verdier, T. Kurca, Horst Severini, Marc Weber, A. Lounis, T. H. Burnett, L. Christofek, Emanuela Barberis, Kazunori Hanagaki, Dongliang Zhang, A. Zylberstejn, K. A. Johns, Chris P. Barnes, R. Hooper, D. Chapin, F. Lehner, François Fleuret, F. Nang, T. C. Bacon, M. R. Krishnaswamy, Sung Keun Park, Chris Hays, A. Evdokimov, H. Greenlee, Daniel Whiteson, Richard B. Lipton, B. C.K. Casey, R. L. McCarthy, Andrew White, M. Merkin, A. Bross, J. M. Hauptman, Cecilia Elena Gerber, M. Petteni, J. N. Butler, P. D. Grannis, Raimund Ströhmer, V. Simak, Charles Leggett, L. Lueking, O. Peters, V. A. Bezzubov, B. Spurlock, G. Ginther, Zeno Dixon Greenwood, J. P. Negret, Karel Smolek, A. Baden, F. Villeneuve-Seguier, F. Charles, H. Dong, Marumi Kado, D. Buchholz, P. Padley, G. C. Blazey, Y. Yen, B. Zhang, Raymond Brock, Boaz Klima, Christos Leonidopoulos, G. A. Davis, Serban Protopopescu, R. P. Smith, Sophie Trincaz-Duvoid, M. Sosebee, Jianming Qian, J. Steele, Cristina Galea, A. Jenkins, Suyong Choi, Xiuping Li, G. Briskin, R. Beuselinck, Y. Coadou, Christophe Royon, Y. Arnoud, Tulika Bose, Kyoung-Ho Kim, Andy Haas, B. M. Sabirov, D. Skow, V. Oguri, R. Yamada, P. Tamburello, E. Popkov, M. Verzocchi, K. Del Signore, J. Kozminski, Michael Hildreth, Jean-Francois Grivaz, Mitchell Wayne, Florian Beaudette, H. Schellman, J. M. Kohli, Anna Goussiou, Robert Harrington, Andrei Nomerotski, S. Söldner-Rembold, P. Skubic, A. Koubarovsky, S. H. Ahn, P. de Jong, D. Kau, Ulrich Heintz, J. Womersley, H. Jöstlein, A. Cothenet, Z. Ke, C. Han, John Hobbs, A. Melnitchouk, P. Jonsson, Jeffrey F. Krane, M. Doidge, Marcel Vreeswijk, J. Wittlin, K. Stevenson, S. Baffioni, J. Hays, H. Haggerty, L. Duflot, Stefan Grünendahl, S. R. Hou, P. A. Rapidis, M. Wobisch, M. Buehler, Gustaaf Brooijmans, D. Mihalcea, C. De Oliveira Martins, Michael Martens, W. Gu, Freya Blekman, J. Barreto, Adam L. Lyon, Frank Filthaut, M. Diesburg, M. Kopal, Stephanie Beauceron, Mark Raymond Adams, D. Karmanov, A. Jonckheere, S. Dean, Sergio F Novaes, H. D. Wahl, P. N. Ratoff, Thomas Hebbeker, S. Uzunyan, M. Mulders, L. Han, C. Luo, Mossadek Talby, B. Gómez, Y. A. Yatsunenko, A. V. Kotwal, Harrison Prosper, S. Desai, S. N. Fatakia, L. S. Vertogradov, P. M. Tuts, V. E. Kuznetsov, D. Bauer, A. Sanchez-Hernandez, J. Lu, V. Zutshi, A. Besson, K. W. Merritt, B. Andrieu, N. R. Stanton, J. F. Bartlett, Stephan Linn, A. Lobodenko, J. Warchol, S. J. De Jong, B. Kothari, K. J. Rani, A. Alton, Shashikant Dugad, D. A. Stoyanova, A. S. Turcot, Heriberto Castilla-Valdez, S. J. Hong, J. Dyer, Gregory R Snow, P.F. Ermolov, Andrew Askew, Zhengguo Zhao, D. K. Cho, Sudhir Malik, Ia Iashvili, Jean-Roch Vlimant, Rodney Walker, N.V. Mokhov, B. Åsman, M. I. Martin, S. Greder, A. P. Heinson, Jaebeom Park, G. S. Muanza, V. M. Podstavkov, S. N. Ahmed, M. Fortner, N. W. Reay, J. Coss, N. Oshima, Arnulf Quadt, Elemer Nagy, R. W. Moore, James C. Green, Kristian Harder, D. Cutts, Tiefu Zhao, G. Steinbrück, T. Wlodek, Wagner Carvalho, Yurii Maravin, Vladimir Gavrilov, Gordon Watts, P. K. Mal, S. Chakrabarti, E. De La Cruz-Burelo, M. Zdrazil, Andrew Brandt, E. Galyaev, W. E. Cooper, W. Kahl, K. Genser, Gregorio Bernardi, D. Denisov, D. Shpakov, M. Cooke, W. L. Prado Da Silva, S. Chopra, A. Yurkewicz, J. M. Heinmiller, Michael Begel, R. E. Hall, Terry Richard Wyatt, V. Manankov, M. Agelou, A. M. Magnan, B. Olivier, Y. Hu, L. Lobo, Greg Landsberg, V. Sirotenko, Frank Fiedler, M. Cristetiu, Hal Evans, Sw. Banerjee, O. V. Eroshin, Y. Song, Thomas Ferbel, Daniel Bloch, Daria Zieminska, R. D. Schamberger, Eduardo De Moraes Gregores, E. Kajfasz, J. Gardner, Lorenzo Feligioni, H.E. Miettinen, Carsten Hensel, H. E. Fisk, Z. Zhou, Ariel Schwartzman, R. J. Madaras, P. Mättig, Arnaud Duperrin, V. M. Korablev, D. Fein, Melissa Ridel, Marvin Johnson, M. Warsinsky, Ulrike Blumenschein, R. Kehoe, D. Chakraborty, N. Wallace, Yu. Gershtein, K. M. Chan, Christian Zeitnitz, Phillip Gutierrez, Zhenbin Wu, Aran Garcia-Bellido, P. L.M. Podesta-Lerma, Boris Tuchming, T. Yasuda, D. Casey, Q. Z. Li, Walter Freeman, J. Kotcher, Jong-Sung Yu, R. Illingworth, A. V. Kozelov, J. F. Renardy, Don Lincoln, Erich Varnes, P. W. Balm, B. Davies, Pedrame Bargassa, Dugan O'Neil, E. G. Zverev, K. Soustruznik, N. J. Buchanan, M. A. Kubantsev, L. Sonnenschein, B. Thooris, T. Nunnemann, B. Baldin, Jean-Laurent Agram, G. Alkhazov, M. Bhattacharjee, George Alverson, S. Anderson, M. A. Strang, C. Hebert, C. S. Mishra, Markus Klute, A. Patwa, Thomas Trefzger, S. Tentindo-Repond, J. A. Parsons, Sebastian Grinstein, Denis Gelé, N. M. Cason, Pierre-Antoine Delsart, M. Gao, L. Phaf, D. Hedin, Brad Abbott, B. Clément, Philip Baringer, S. Jabeen, Sharon Hagopian, K. Papageorgiou, Alexander Leflat, David Colling, M. Strovink, H. Weerts, Z. M. Wang, S. Kesisoglou, V. M. Abazov, A. Bischoff, Pierre Petroff, Christopher George Tully, Harald Fox, J. Fast, K. Gounder, J. R. Kalk, B. G. Pope, A. B. Meyer, T. Christiansen, H. A. Neal, Emmanuel Busato, J. Zhu, W. M. Lee, A. Kharchilava, O. Kouznetsov, M. Binder, Jing Li, D. Meder, O. Atramentov, J. T. Linnemann, Norbert Wermes, Guennadi Borissov, Meenakshi Narain, Shuichi Kunori, Sherry Towers, G. Geurkov, V. Sorín, K. Yip, N. Xuan, R. Van Kooten, G. D. Alexeev, Flera Rizatdinova, J. Torborg, Elizaveta Shabalina, Y. M. Kharzheev, S. Sengupta, Patrick Slattery, Gilvan Alves, L. Coney, M. D. Corcoran, G. J. Otero y Garzón, L. Stutte, P. Johnson, R. Zitoun, M. Lynker, R. Piegaia, Andre Sopczak, Sergey Kuleshov, M. Vaupel, Jonas Strandberg, C. Noeding, N. Parua, M. B. Przybycien, A.S. Dyshkant, Frederic Deliot, G. Savage, Iain Alexander Bertram, J. Lazoflores, X. F. Song, D. Evans, M. Eads, M. Jaffré, X. Meng, Pushpalatha C Bhat, Juan Estrada, J. Bystricky, G. Graham, Reiner Hauser, W. C. Fisher, Elliott Cheu, A. Zieminski, Michael Rijssenbeek, M. A.C. Cummings, Arnaud Lucotte, B. Hoeneisen, Lee Sawyer, Alexander Kupco, J. Huang, Victor Daniel Elvira, Randy Ruchti, R. A. Sidwell, S. W. Youn, E. Von Toerne, S.A. Kahn, Y. D. Mutaf, P. Demine, I. A. Vasilyev, P. M. Perea, T. Toole, V. Buescher, M. Demarteau, S. E.K. Mattingly, Carmen García, M. Hohlfeld, Wendy Taylor, D. Wicke, V. V. Shary, Vivek Jain, Q. Xu, H. Zheng, D. Coppage, Paul Telford, Neeti Parashar, Alexander Khanov, V. N. Evdokimov, I. Ripp-Baudot, I. Hall, A. Chandra, M. P. Sanders, N. A. Naumann, S. Lager, S. Reucroft, Seo Won Lee, D. Käfer, A. Bellavance, A. Magerkurth, A. Zatserklyaniy, B. S. Acharya, S. Uvarov, H. L. Melanson, M. Wegner, M. Zielinski, B. Quinn, Makoto Tomoto, David H. Adams, Alice Bean, S. N. Gurzhiev, F. Canelli, N. Oliveira, Vipin Bhatnagar, Viatcheslav Stolin, N. Lahrichi, R. Partridge, X. Zhang, Christian Autermann, Manas Maity, J. Molina, V. L. Malyshev, J. Rha, H. S. Mao, E. Thomas, Carlos Avila, Sabine Crépé-Renaudin, Graham Wilson, H. da Motta, A. S. Ito, V. V. Lipaev, Yu-tin Huang, Nikos Varelas, Bing Zhou, Laurent Chevalier, Stephen Wimpenny, Martin Grunewald, A. R. Clark, V. White, T. Marshall, Milos Lokajicek, Darien Wood, Nicholas John Hadley, Scott Snyder, D. R. Claes, Gavin Davies, S. Doulas, Kaushik De, I. Blackler, Jan Stark, Henry Lubatti, Michael A. Strauss, P. Lebrun, C. Boswell, O. Boeriu, Y. Kulik, A. Stone, Tobias Golling, T. Scanlon, S. Kermiche, Suman Bala Beri, Vivian O'Dell, A. Juste, P. Bonamy, Todd Adams, A. C. Le Bihan, Tuan Vu Anh, D. Edmunds, W. D. Shephard, R. McCroskey, Andre Sznajder, Emmanuelle Perez, K. Goldmann, L. Babukhadia, Reinhard Schwienhorst, Y. Jiang, B. Connolly, M. C. Cousinou, W. M. Van Leeuwen, S. Fu, R. Bernhard, D. A. Wijngaarden, G. Hesketh, K. Bos, Marc Besancon, J. Temple, Robert Hirosky, Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), D0, Universidad de Buenos Aires, Centro Brasileiro de Pesquisas Físicas, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Estadual Paulista (UNESP), University of Alberta, Simon Fraser University, Institute of High Energy Physics, Universidad de los Andes, Charles University, Czech Technical University, Center for Particle Physics, Universidad San Francisco de Quito, IN2P3-CNRS, Université de la Méditerranée, Universités Paris VI and VII, CEA, Université Louis Pasteur Strasbourg, Université de Haute Alsace, Université Claude Bernard, III. Physikalisches Institut A, Universität Bonn, Universität Freiburg, Universität Mainz, Ludwig-Maximilians-Universität München, University of Wuppertal, Panjab University, Tata Institute of Fundamental Research, University College Dublin, Korea University, CINVESTAV, FOM-Institute NIKHEF and University of Amsterdam/NIKHEF, University of Nijmegen/NIKHEF, Joint Institute for Nuclear Research, Institute for Theoretical and Experimental Physics, Moscow State University, Institute for High Energy Physics, Petersburg Nuclear Physics Institute, Lund University, Stockholm University, Uppsala University, Lancaster University, Imperial College, University of Manchester, University of Arizona, University of California, California State University, Florida State University, Fermi National Accelerator Laboratory, University of Illinois at Chicago, Northern Illinois University, Northwestern University, Indiana University, University of Notre Dame, Iowa State University, University of Kansas, Kansas State University, Louisiana Tech University, University of Maryland, Boston University, Northeastern University, University of Michigan, Michigan State University, University of Mississippi, University of Nebraska, Princeton University, Columbia University, University of Rochester, State University of New York, Brookhaven National Laboratory, Langston University, University of Oklahoma, Brown University, University of Texas, Rice University, University of Virginia, University of Washington, University of Zurich, Institute of Nuclear Physics, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)
Subjects: Particle physics, standard model, Tevatron, General Physics and Astronomy, FOS: Physical sciences, sparticles, 01 natural sciences, Standard Model, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics::Theory, Chargino, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Grand Unified Theory, 14.80.Ly, 12.60.Jv, 13.85.Rm, Symmetry breaking, 010306 general physics, Physics, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Superpartner, spontaneous symmetry breaking, Supersymmetry, Neutralino, High Energy Physics::Experiment, supersymmetry
Abstract: We report the results of a search for supersymmetry (SUSY) with gauge-mediated breaking in the missing transverse energy distribution of inclusive diphoton events using 263 pb$^{-1}$ of data collected by the D0 experiment at the Fermilab Tevatron Collider in 2002--2004. No excess is observed above the background expected from standard model processes, and lower limits on the masses of the lightest neutralino and chargino of about 108 and 195 GeV, respectively, are set at the 95% confidence level. These are the most stringent limits to date for models with gauge-mediated SUSY breaking with a short-lived neutralino as the next-lightest SUSY particle., Comment: 7 pages, 2 figures
Published: 2005
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39. Identification of the novelHLA-C*07:315allele

Author: Birgit Lauer, K Goldmann, and Bernd M. Spriewald
Subjects: Genetics, Immunology, Substitution (logic), General Medicine, Human leukocyte antigen, Biology, Biochemistry, Null allele, HLA-C, Exon, Immunology and Allergy, Identification (biology), Allele
Abstract: The HLA-C*07:315 allele is mostly identical to HLA-C*07:09 but has a non-synonymous substitution of C to G in exon 2.
Published: 2013
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40. Attenuation of Transplant Arteriosclerosis by Oral Feeding of MHC Encoding Chitosan-DNA Nanoparticles Is Mediated by Humoral Immunity

Author: S. Eckl, Christian Heim, K Goldmann, Stephan M. Ensminger, and Bernd M. Spriewald
Subjects: Pulmonary and Respiratory Medicine, Heart transplantation, Transplantation, Intimal hyperplasia, biology, business.industry, medicine.medical_treatment, medicine.disease, Major histocompatibility complex, Ovalbumin, Immune system, Antigen, Humoral immunity, Immunology, medicine, biology.protein, Surgery, Cardiology and Cardiovascular Medicine, business
Abstract: Purpose One promising approach for the induction of transplant tolerance is the pre-treatment of transplant recipients with donor MHC-alloantigen. Our study focuses on the oral delivery of MHC-antigen encoding genes via chitosan-DNA nanoparticles to modulate the allo-immune response in order to reduce the development of transplant arteriosclerosis, the hallmark feature of chronic rejection after heart transplantation. Methods and Materials We performed fully allogeneic mouse abdominal aortic transplantats using C57BL/6 (H2 b ) mice as donors and CBA.J (H2 k ) mice as recipients Aortic grafts were analyzed by histology and morphometry on day 30 after transplantation, levels of circulating alloantibodies were detected by FACS analysis. Results Pre-treatment of recipient mice with chitosan-DNA nanoparticles encoding for K b , one of the MHC-I molecules of the donor, resulted in a significant reduction of intimal proliferation compared to untreated controls. When Ovalbumin was fed instead of K b encoding nanoparticles (K b -NP) or Balb/c (H2 d ) grafts were used instead of C57BL/6 (H2 b ) grafts as antigen controls, both groups showed no reduction of intimal thickness indicating an antigen-specific mechanism. In addition, analysis of peripheral blood of the transplanted mice showed significant suppression of alloantibody formation in the K b -NP fed group compared to all other allogeneic transplanted groups suggesting modulation of the humoral immune response. Conclusions These results demonstrate the potential of chitosan-DNA nanoparticles to induce K b -specific tolerance and to reduce the development of transplant arteriosclerosis.
Published: 2013
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41. Observation and Properties of theX(3872)Decaying toJ/ψπ+π−inpp¯Collisions ats=1.96 TeV

Author: Kristian Harder, A. Cothenet, D. Cutts, J. Lu, V. Zutshi, R. L. McCarthy, Ulrich Heintz, L. Christofek, Wagner Carvalho, Greg Landsberg, Laurent Chevalier, Raimund Ströhmer, M. Abolins, Andrew Askew, Zhengguo Zhao, L. S. Vertogradov, Sergey Burdin, D. Shpakov, Stephen Wimpenny, P. K. Mai, Martin Grunewald, A. R. Clark, S. Söldner-Rembold, S. P. Denisov, H. Jöstlein, Frank Filthaut, M. Diesburg, F. Villeneuve-Seguier, Sung Keun Park, V. White, T. Marshall, Milos Lokajicek, Pedrame Bargassa, V. Simak, P.F. Ermolov, M. R. Krishnaswamy, P. Padley, D. K. Cho, Y. Arnoud, K. Soustruznik, M. Buehler, Y. Jiang, B. Connolly, M. C. Cousinou, S. Chakrabarti, Vipin Bhatnagar, N. Lahrichi, R. Partridge, X. Zhang, Christian Autermann, Darien Wood, V. L. Malyshev, J. Rha, H. S. Mao, D. A. Stoyanova, E. Thomas, Emily Nurse, Pushpalatha C Bhat, A. S. Turcot, Elizabeth Gallas, T. McMahon, N. R. Stanton, L. Lueking, A. Besson, Kevin Black, T. Toole, Nicholas John Hadley, W. E. Cooper, Mitchell Wayne, H. Schellman, J. M. Kohli, S. Lager, F. Borcherding, S. Uvarov, N. K. Mondal, H. L. Melanson, M. Wegner, P. Schieferdecker, H. T. Diehl, T. A. Bolton, Jonas Strandberg, G. Alkhazov, B. Quinn, R. J. Madaras, Reiner Hauser, Stefan Grünendahl, Makoto Tomoto, David H. Adams, E. Popkov, Alice Bean, K. Del Signore, Dugan O'Neil, E. G. Zverev, A. Patwa, N. Parua, G. Sajot, S. R. Hou, Mossadek Talby, B. Gómez, J. Kasper, K. J. Rani, F. Canelli, N. Oliveira, A. Alton, Arnaud Duperrin, Emanuela Barberis, Kazunori Hanagaki, Dongliang Zhang, Adam L. Lyon, S. E.K. Mattingly, W. Gu, A. Boehnlein, Scott Snyder, M. A.C. Cummings, Denis Gelé, B. Vachon, V. M. Korablev, Markus Klute, J. N. Butler, P. D. Grannis, Michael Begel, J. Gardner, George Alverson, C. Han, D. Casey, Wendy Taylor, Eduardo De Moraes Gregores, W. M. Van Leeuwen, N. M. Cason, Boris Tuchming, B. Hoeneisen, Lee Sawyer, Walter Freeman, J. Kotcher, S. Anderson, D. Mihalcea, C. De Oliveira Martins, M. Eads, Harald Fox, P. Mättig, David Colling, J. Ellison, R. Hooper, M. Vaupel, Y. D. Mutaf, I. A. Vasilyev, P. M. Perea, P. N. Ratoff, R. Illingworth, Miguel Mostafa, D. Hedin, Cris W. Barnes, R. W. Moore, Charles Leggett, M. Jaffré, Johannes Elmsheuser, S. Kesisoglou, Chris Hays, V. A. Bezzubov, P. M. Tuts, V. E. Kuznetsov, Zhenbin Wu, Sarah Catherine Eno, Meenakshi Narain, Sherry Towers, Shashikant Dugad, Jong-Sung Yu, M. Merkin, Robert Hirosky, Arnulf Quadt, J. P. Negret, J. T. Eltzroth, P. Neustroev, Elemer Nagy, Graham Wilson, D. Chapin, H. da Motta, A. K.A. Maciel, Sa. Jain, S. Fuess, T. Kurca, Marc Weber, D. A. Wijngaarden, R. P. Smith, Sophie Trincaz-Duvoid, Emmanuel Busato, J. Zhu, S.A. Kahn, F. Charles, R. Jesik, F. Blekman, D. Fein, D. Chakraborty, J. Kozminski, Michael Hildreth, A. M. Kalinin, S. Tentindo-Repond, D. Kau, M. Demarteau, Marvin Johnson, M. Warsinsky, A. V. Kozelov, François Fleuret, F. Nang, Andrew White, Tulika Bose, M. Verzocchi, J. Lazoflores, K. M. Chan, Christian Zeitnitz, Jovan Mitrevski, G. Gutierrez, K. A. Johns, G. Hesketh, Philip Baringer, Arnaud Lucotte, A. S. Ito, L. Phaf, Richard B. Lipton, I. Ripp-Baudot, Alexander Kupco, A. Baden, A. Meyer, K. Stevenson, S. W. Youn, S. Uzunyan, Christian Schmitt, S. Nelson, M. H.G. Souza, B. Davies, Don Lincoln, Erich Varnes, Carmen García, Guennadi Borissov, S. Jabeen, H. Haggerty, D. Wicke, Gilvan Alves, B. Olivier, S. Banerjee, B. Thooris, R. Gelhaus, H. E. Montgomery, V. S. Narasimham, Thomas Trefzger, G. C. Blazey, Y. Yen, B. Zhang, T. C. Bacon, M. Sosebee, Q. Z. Li, Raymond Brock, Boaz Klima, K. Bos, Marc Besancon, J. Temple, L. Lobo, M. P. Sanders, P. Bonamy, B. G. Pope, Lorenzo Feligioni, Alexandre Zabi, A. Kouchner, D. R. Claes, Gavin Davies, R. Yamada, S. J. De Jong, T. Nunnemann, Jean-Francois Grivaz, S. H. Ahn, B. Baldin, P. de Jong, R. Beuselinck, Z. Ke, P. W. Balm, Y. A. Yatsunenko, P. Verdier, A. V. Kotwal, Harrison Prosper, S. Desai, S. J. Hong, V. M. Abazov, V. Shary, W. Kahl, Abdenour Lounis, Frederic Deliot, Christopher George Tully, L. Sonnenschein, M. Bhattacharjee, A. M. Magnan, Neeti Parashar, Y. M. Kharzheev, Patrick Slattery, S. Doulas, C. Hebert, B. Kothari, P. Jonsson, J. Coss, M. Mulders, L. Han, C. Luo, Mary Beth Adams, Pierre-Antoine Delsart, Sharon Hagopian, M. Kopal, J. Torborg, S. Greder, Iain Alexander Bertram, Kaushik De, Daniel Whiteson, G. D. Alexeev, Flera Rizatdinova, Andrei Nomerotski, Randy Ruchti, M. B. Przybycien, L. Groer, Thomas G Trippe, Karl Jakobs, A. A. Mayorov, P. Lewis, J. Snow, Christophe Clement, W. M. Lee, A. Kharchilava, Michael Rijssenbeek, G. J. Otero y Garzón, M. Zielinski, E. De La Cruz-Burelo, M. Zdrazil, J. A. Parsons, Sebastian Grinstein, A. Evdokimov, M. Petteni, K. Papageorgiou, Marcel Vreeswijk, Zeno Dixon Greenwood, Marumi Kado, Alexander Leflat, Elizaveta Shabalina, A. Zatserklyaniy, R. Zitoun, M. Strovink, Sergio F Novaes, John Hobbs, G. S. Muanza, D. Evans, James C. Green, Frank Fiedler, I. Blackler, Karel Smolek, H. Dong, Andrew Brandt, Jf Renardy, V. N. Evdokimov, I. Hall, E. Kajfasz, K. W. Merritt, V. Buescher, J. Barreto, D. Buchholz, A. Chandra, H.E. Miettinen, Carsten Hensel, A. Jenkins, B. M. Sabirov, J. Steele, O. Kouznetsov, Heriberto Castilla-Valdez, S. N. Gurzhiev, D. Skow, C. Noeding, J. F. Bartlett, Yurii Maravin, Cristina Galea, Vladimir Gavrilov, Andre Sopczak, Sergey Kuleshov, P. Johnson, B. Andrieu, Elliott Cheu, V. Manankov, A. Bischoff, Jing Li, P. A. Rapidis, T. V. Anh, Xiuping Li, P. Tamburello, Christophe Royon, Jan Stark, Henry Lubatti, R. Piegaia, L. Duflot, Florian Beaudette, Anna Goussiou, A. Melnitchouk, Viatcheslav Stolin, M. Agelou, Gordon Watts, V. Oguri, A. Koubarovsky, K. Gounder, J. R. Kalk, V. Sirotenko, A. C. Le Bihan, G. Geurkov, M. Cristetiu, Manas Maity, A. Jonckheere, S. Dean, D. Edmunds, J. Molina, Stephan Linn, A. Lobodenko, J. Hays, N.V. Mokhov, Carlos Avila, J. Dyer, Gregory R Snow, Sabine Crépé-Renaudin, Gustaaf Brooijmans, O. V. Eroshin, Y. Song, L. Coney, H. D. Wahl, D. Bauer, B. Åsman, M. I. Martin, Suyong Choi, Phillip Gutierrez, N. Oshima, Victor Daniel Elvira, Daniel Bloch, Daria Zieminska, A. P. Heinson, A. A. Schukin, J. Warchol, T. Edwards, Michael Martens, R. D. Schamberger, N. Wallace, Shuichi Kunori, Gregorio Bernardi, J. Fast, D. Denisov, C. Miao, O. Peters, G. Savage, X. Meng, T. R. Wyatt, M. A. Kubantsev, J. M. Heinmiller, R. E. Hall, E. Galyaev, Hal Evans, Thomas Ferbel, M. A. Strang, Juan Estrada, W. L. Prado Da Silva, C. S. Mishra, S. Chopra, A. Yurkewicz, W. D. Shephard, Yu-tin Huang, Lev Uvarov, P. Hanlet, S. Krzywdzinski, Ariel Schwartzman, Nikos Varelas, T. Yasuda, Bing Zhou, Melissa Ridel, R. Kehoe, A. Zylberstejn, F. Lehner, H. Greenlee, B. C.K. Casey, A. Bross, H. Weerts, G. A. Davis, Z. M. Wang, Serban Protopopescu, M. Binder, Kyoung-Ho Kim, Andy Haas, R. McCroskey, Andre Sznajder, M. Lynker, A. Sénchez-Hernández, X. F. Song, S. N. Fatakia, Jaebeom Park, V. M. Podstavkov, S. Sengupta, E. Von Toerne, P. Demine, M. Hohlfeld, H. Zheng, S. N. Ahmed, M. Fortner, N. W. Reay, D. Coppage, Yuri Gershtein, Y. Hu, Emmanuelle Perez, N. A. Naumann, S. Reucroft, K. Goldmann, Seo Won Lee, D. Käfer, L. Babukhadia, Reinhard Schwienhorst, Michael A. Strauss, P. Lebrun, C. Boswell, Y. Kulik, A. Stone, Tobias Golling, T. Scanlon, S. Kermiche, Suman Bala Beri, Vivian O'Dell, A. Juste, Todd Adams, J. M. Hauptman, Cecilia Elena Gerber, Christos Leonidopoulos, G. Ginther, J. Womersley, Jianming Qian, T. H. Burnett, J. Wittlin, M. Wobisch, Stephanie Beauceron, D. Karmanov, G. Briskin, Sudhir Malik, Ia Iashvili, Jeffrey F. Krane, M. Doidge, Jean-Roch Vlimant, Rodney Walker, S. Baffioni, U. Bassler, T. Christiansen, Bobby Samir Acharya, H. A. Neal, D. Meder, Regina Demina, Alberto Santoro, J. G.R. Lima, P. Rubinov, J. T. Linnemann, V. Sorín, K. Yip, N. Xuan, H. E. Fisk, Z. Zhou, Aran Garcia-Bellido, M. Gao, L. Stutte, A.S. Dyshkant, Tiefu Zhao, G. Steinbrück, T. Wlodek, K. Genser, Ulrike Blumenschein, P. L.M. Podesta-Lerma, Jean-Laurent Agram, Brad Abbott, Pierre Petroff, S. Fu, Vivek Jain, Q. Xu, Paul Telford, Alexander Khanov, R. Van Kooten, M. D. Corcoran, J. Bystricky, G. Graham, A. Zieminski, J. Huang, R. A. Sidwell, and Y. Coadou
Subjects: Physics, Nuclear physics, Particle decay, Meson, 010308 nuclear & particles physics, 0103 physical sciences, General Physics and Astronomy, High Energy Physics::Experiment, B meson, 010306 general physics, 01 natural sciences, X(3872), Bar (unit)
Abstract: We report the observation of the X(3872) in the J/psipi(+)pi(-) channel, with J/psi decaying to mu(+)mu(-), in p (p) over bar collisions at roots=1.96 TeV. Using approximately 230 pb(-1) of data collected with the Run II D0 detector, we observe 522+/-100 X(3872) candidates. The mass difference between the X(3872) state and the J/psi is measured to be 774.9+/-3.1(stat)+/-3.0(syst) MeV/c(2). We have investigated the production and decay characteristics of the X(3872) and find them to be similar to those of the psi(2S) state.
Published: 2004
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42. Observation and properties of the X(3872) decaying to J/psipi(+)pi(-) in pp collisions at sqrt[s]=1.96 TeV

Author: V M, Abazov, B, Abbott, M, Abolins, B S, Acharya, D L, Adams, M, Adams, T, Adams, M, Agelou, J-L, Agram, S N, Ahmed, S H, Ahn, G D, Alexeev, G, Alkhazov, A, Alton, G, Alverson, G A, Alves, S, Anderson, B, Andrieu, Y, Arnoud, A, Askew, B, Asman, C, Autermann, C, Avila, L, Babukhadia, T C, Bacon, A, Baden, S, Baffioni, B, Baldin, P W, Balm, S, Banerjee, E, Barberis, P, Bargassa, P, Baringer, C, Barnes, J, Barreto, J F, Bartlett, U, Bassler, D, Bauer, A, Bean, S, Beauceron, F, Beaudette, M, Begel, S B, Beri, G, Bernardi, I, Bertram, M, Besançon, A, Besson, R, Beuselinck, V A, Bezzubov, P C, Bhat, V, Bhatnagar, M, Bhattacharjee, M, Binder, A, Bischoff, K M, Black, I, Blackler, G, Blazey, F, Blekman, D, Bloch, U, Blumenschein, A, Boehnlein, T A, Bolton, P, Bonamy, F, Borcherding, G, Borissov, K, Bos, T, Bose, C, Boswell, A, Brandt, G, Briskin, R, Brock, G, Brooijmans, A, Bross, D, Buchholz, M, Buehler, V, Buescher, S, Burdin, T H, Burnett, E, Busato, J M, Butler, J, Bystricky, F, Canelli, W, Carvalho, B C K, Casey, D, Casey, N M, Cason, H, Castilla-Valdez, S, Chakrabarti, D, Chakraborty, K M, Chan, A, Chandra, D, Chapin, F, Charles, E, Cheu, L, Chevalier, D K, Cho, S, Choi, S, Chopra, T, Christiansen, L, Christofek, D, Claes, A R, Clark, C, Clément, Y, Coadou, D J, Colling, L, Coney, B, Connolly, W E, Cooper, D, Coppage, M, Corcoran, J, Coss, A, Cothenet, M-C, Cousinou, S, Crépé-Renaudin, M, Cristetiu, M A C, Cummings, D, Cutts, H, da Motta, B, Davies, G, Davies, G A, Davis, K, De, P, de Jong, S J, de Jong, E, De La Cruz-Burelo, C, De Oliveira Martins, S, Dean, K, Del Signore, F, Déliot, P A, Delsart, M, Demarteau, R, Demina, P, Demine, D, Denisov, S P, Denisov, S, Desai, H T, Diehl, M, Diesburg, M, Doidge, H, Dong, S, Doulas, L, Duflot, S R, Dugad, A, Duperrin, J, Dyer, A, Dyshkant, M, Eads, D, Edmunds, T, Edwards, J, Ellison, J, Elmsheuser, J T, Eltzroth, V D, Elvira, S, Eno, P, Ermolov, O V, Eroshin, J, Estrada, D, Evans, H, Evans, A, Evdokimov, V N, Evdokimov, J, Fast, S N, Fatakia, D, Fein, L, Feligioni, T, Ferbel, F, Fiedler, F, Filthaut, H E, Fisk, F, Fleuret, M, Fortner, H, Fox, W, Freeman, S, Fu, S, Fuess, C F, Galea, E, Gallas, E, Galyaev, M, Gao, C, Garcia, A, Garcia-Bellido, J, Gardner, V, Gavrilov, D, Gelé, R, Gelhaus, K, Genser, C E, Gerber, Y, Gershtein, G, Geurkov, G, Ginther, K, Goldmann, T, Golling, B, Gómez, K, Gounder, A, Goussiou, G, Graham, P D, Grannis, S, Greder, J A, Green, H, Greenlee, Z D, Greenwood, E M, Gregores, S, Grinstein, J-F, Grivaz, L, Groer, S, Grünendahl, M W, Grünewald, W, Gu, S N, Gurzhiev, G, Gutierrez, P, Gutierrez, A, Haas, N J, Hadley, H, Haggerty, S, Hagopian, I, Hall, R E, Hall, C, Han, L, Han, K, Hanagaki, P, Hanlet, K, Harder, J M, Hauptman, R, Hauser, C, Hays, J, Hays, C, Hebert, D, Hedin, J M, Heinmiller, A P, Heinson, U, Heintz, C, Hensel, G, Hesketh, M D, Hildreth, R, Hirosky, J D, Hobbs, B, Hoeneisen, M, Hohlfeld, S J, Hong, R, Hooper, S, Hou, Y, Hu, J, Huang, Y, Huang, I, Iashvili, R, Illingworth, A S, Ito, S, Jabeen, M, Jaffré, S, Jain, V, Jain, K, Jakobs, A, Jenkins, R, Jesik, Y, Jiang, K, Johns, M, Johnson, P, Johnson, A, Jonckheere, P, Jonsson, H, Jöstlein, A, Juste, M M, Kado, D, Käfer, W, Kahl, S, Kahn, E, Kajfasz, A M, Kalinin, J, Kalk, D, Karmanov, J, Kasper, D, Kau, Z, Ke, R, Kehoe, S, Kermiche, S, Kesisoglou, A, Khanov, A, Kharchilava, Y M, Kharzheev, K H, Kim, B, Klima, M, Klute, J M, Kohli, M, Kopal, V, Korablev, J, Kotcher, B, Kothari, A V, Kotwal, A, Koubarovsky, A, Kouchner, O, Kouznetsov, A V, Kozelov, J, Kozminski, J, Krane, M R, Krishnaswamy, S, Krzywdzinski, M, Kubantsev, S, Kuleshov, Y, Kulik, S, Kunori, A, Kupco, T, Kurca, V E, Kuznetsov, S, Lager, N, Lahrichi, G, Landsberg, J, Lazoflores, A-C, Le Bihan, P, Lebrun, S W, Lee, W M, Lee, A, Leflat, C, Leggett, F, Lehner, C, Leonidopoulos, P, Lewis, J, Li, Q Z, Li, X, Li, J G R, Lima, D, Lincoln, S L, Linn, J, Linnemann, R, Lipton, L, Lobo, A, Lobodenko, M, Lokajicek, A, Lounis, J, Lu, H J, Lubatti, A, Lucotte, L, Lueking, C, Luo, M, Lynker, A L, Lyon, A K A, Maciel, R J, Madaras, P, Mättig, A-M, Magnan, M, Maity, P K, Mal, S, Malik, V L, Malyshev, V, Manankov, H S, Mao, Y, Maravin, T, Marshall, M, Martens, M I, Martin, S E K, Mattingly, A A, Mayorov, R, McCarthy, R, McCroskey, T, McMahon, D, Meder, H L, Melanson, A, Melnitchouk, X, Meng, M, Merkin, K W, Merritt, A, Meyer, C, Miao, H, Miettinen, D, Mihalcea, C S, Mishra, J, Mitrevski, N, Mokhov, J, Molina, N K, Mondal, H E, Montgomery, R W, Moore, M, Mostafa, G S, Muanza, M, Mulders, Y D, Mutaf, E, Nagy, F, Nang, M, Narain, V S, Narasimham, N A, Naumann, H A, Neal, J P, Negret, S, Nelson, P, Neustroev, C, Noeding, A, Nomerotski, S F, Novaes, T, Nunnemann, E, Nurse, V, O'Dell, D C, O'Neil, V, Oguri, N, Oliveira, B, Olivier, N, Oshima, G J, Otero y Garzón, P, Padley, K, Papageorgiou, N, Parashar, J, Park, S K, Park, J, Parsons, R, Partridge, N, Parua, A, Patwa, P M, Perea, E, Perez, O, Peters, P, Pétroff, M, Petteni, L, Phaf, R, Piegaia, P L M, Podesta-Lerma, V M, Podstavkov, B G, Pope, E, Popkov, W L, Prado da Silva, H B, Prosper, S, Protopopescu, M B, Przybycien, J, Qian, A, Quadt, B, Quinn, K J, Rani, P A, Rapidis, P N, Ratoff, N W, Reay, J-F, Renardy, S, Reucroft, J, Rha, M, Ridel, M, Rijssenbeek, I, Ripp-Baudot, F, Rizatdinova, C, Royon, P, Rubinov, R, Ruchti, B M, Sabirov, G, Sajot, A, Sánchez-Hernández, M P, Sanders, A, Santoro, G, Savage, L, Sawyer, T, Scanlon, R D, Schamberger, H, Schellman, P, Schieferdecker, C, Schmitt, A, Schukin, A, Schwartzman, R, Schwienhorst, S, Sengupta, E, Shabalina, V, Shary, W D, Shephard, D, Shpakov, R A, Sidwell, V, Simak, V, Sirotenko, D, Skow, P, Slattery, R P, Smith, K, Smolek, G R, Snow, J, Snow, S, Snyder, S, Söldner-Rembold, X, Song, Y, Song, L, Sonnenschein, A, Sopczak, V, Sorín, M, Sosebee, K, Soustruznik, M, Souza, N R, Stanton, J, Stark, J, Steele, G, Steinbrück, K, Stevenson, V, Stolin, A, Stone, D A, Stoyanova, J, Strandberg, M A, Strang, M, Strauss, R, Ströhmer, M, Strovink, L, Stutte, A, Sznajder, M, Talby, P, Tamburello, W, Taylor, P, Telford, J, Temple, S, Tentindo-Repond, E, Thomas, B, Thooris, M, Tomoto, T, Toole, J, Torborg, S, Towers, T, Trefzger, S, Trincaz-Duvoid, T G, Trippe, B, Tuchming, C, Tully, A S, Turcot, P M, Tuts, L, Uvarov, S, Uvarov, S, Uzunyan, B, Vachon, R, Van Kooten, W M, van Leeuwen, N, Varelas, E W, Varnes, I, Vasilyev, M, Vaupel, P, Verdier, L S, Vertogradov, M, Verzocchi, F, Villeneuve-Seguier, J-R, Vlimant, E, Von Toerne, M, Vreeswijk, T, Vu Anh, H D, Wahl, R, Walker, N, Wallace, Z-M, Wang, J, Warchol, M, Warsinsky, G, Watts, M, Wayne, M, Weber, H, Weerts, M, Wegner, A, White, V, White, D, Whiteson, D, Wicke, D A, Wijngaarden, G W, Wilson, S J, Wimpenny, J, Wittlin, T, Wlodek, M, Wobisch, J, Womersley, D R, Wood, Z, Wu, T R, Wyatt, Q, Xu, N, Xuan, R, Yamada, T, Yasuda, Y A, Yatsunenko, Y, Yen, K, Yip, S W, Youn, J, Yu, A, Yurkewicz, A, Zabi, A, Zatserklyaniy, M, Zdrazil, C, Zeitnitz, B, Zhang, D, Zhang, X, Zhang, T, Zhao, Z, Zhao, H, Zheng, B, Zhou, Z, Zhou, J, Zhu, M, Zielinski, D, Zieminska, A, Zieminski, R, Zitoun, V, Zutshi, E G, Zverev, and A, Zylberstejn
Subjects: High Energy Physics::Experiment, Nuclear Experiment
Abstract: We report the observation of the X(3872) in the J/psipi(+)pi(-) channel, with J/psi decaying to mu(+)mu(-), in pp collisions at sqrt[s]=1.96 TeV. Using approximately 230 pb(-1) of data collected with the Run II D0 detector, we observe 522+/-100 X(3872) candidates. The mass difference between the X(3872) state and the J/psi is measured to be 774.9+/-3.1(stat)+/-3.0(syst) MeV/c(2). We have investigated the production and decay characteristics of the X(3872) and find them to be similar to those of the psi(2S) state.
Published: 2004

43. Search for Doubly Charged Higgs Boson Pair Production in the Decay toμ+μ+μ−μ−inpp¯Collisions ats=1.96 TeV

Author: Suyong Choi, A. Cothenet, Robert Hirosky, A. M. Kalinin, Jovan Mitrevski, A. Sanchez-Hernandez, Michael A. Strauss, G. Gutierrez, Gilvan Alves, M. Sosebee, Raimund Ströhmer, V. Simak, P. Lebrun, J. Lu, V. Zutshi, Chris Hays, A. A. Schukin, P. Padley, C. Boswell, S. Kesisoglou, V. S. Narasimham, L. Groer, Thomas G Trippe, Karl Jakobs, Z. Ke, Gregorio Bernardi, J. Fast, D. Denisov, B. Davies, E. Von Toerne, P. Demine, L. Christofek, V. A. Bezzubov, Y. Kulik, L. Sonnenschein, J. P. Negret, R. P. Smith, T. Edwards, A. Stone, M. Bhattacharjee, J. M. Heinmiller, A. M. Magnan, Hal Evans, Thomas Ferbel, A. A. Mayorov, Mitchell Wayne, H. Schellman, J. M. Kohli, H. Zheng, C. Miao, Tobias Golling, T. Scanlon, S. Kermiche, Andrew Askew, Zhengguo Zhao, D. Shpakov, Pierre-Antoine Delsart, Sharon Hagopian, K. Papageorgiou, Stefan Grünendahl, E. De La Cruz-Burelo, Adam L. Lyon, P. Lewis, J. Snow, Christophe Clement, D. Coppage, S. Fu, J. Kasper, Sophie Trincaz-Duvoid, Suman Bala Beri, J. Kozminski, Michael Hildreth, M. Strovink, Vivian O'Dell, S. R. Hou, D. Kau, A. Juste, M. Zdrazil, Andrew Brandt, Mossadek Talby, B. Gómez, Arnulf Quadt, Christophe Royon, Lev Uvarov, P. Hanlet, R. Hooper, Todd Adams, P. Johnson, Elemer Nagy, K. Stevenson, Andrew White, Shashikant Dugad, Vivek Jain, Q. Xu, Alexandre Zabi, P. Verdier, S. N. Gurzhiev, A. Evdokimov, N. A. Naumann, M. Petteni, M. Kopal, Paul Telford, R. Piegaia, D. Wicke, B. Olivier, A. Jenkins, S. Uzunyan, Y. A. Yatsunenko, B. M. Sabirov, J. Steele, D. Edmunds, A. Melnitchouk, W. D. Shephard, H.E. Miettinen, Carsten Hensel, L. Lobo, Lorenzo Feligioni, A. V. Kotwal, Harrison Prosper, M. Abolins, J. M. Hauptman, Alexander Khanov, Cecilia Elena Gerber, P. A. Rapidis, R. McCroskey, Andre Sznajder, F. Blekman, S. Desai, Andrei Nomerotski, Viatcheslav Stolin, Jonas Strandberg, H. D. Wahl, D. Bauer, S. J. Hong, B. G. Pope, Yuri Gershtein, Emmanuelle Perez, C. Noeding, Kevin Black, T. V. Anh, John Hobbs, Manas Maity, A. Besson, J. Molina, Sung Keun Park, F. Villeneuve-Seguier, S. Reucroft, Seo Won Lee, D. Käfer, A. Jonckheere, S. Dean, J. Barreto, G. Ginther, Carlos Avila, N. K. Mondal, Sabine Crépé-Renaudin, K. Goldmann, Stephan Linn, A. Lobodenko, O. Peters, E. Galyaev, L. Babukhadia, P. Schieferdecker, H. T. Diehl, T. A. Bolton, Ulrich Heintz, Heriberto Castilla-Valdez, W. Gu, N. Parua, K. J. Rani, A. Alton, L. Lueking, M. Eads, Guennadi Borissov, Jianming Qian, V. M. Abazov, V. Shary, Karel Smolek, Reinhard Schwienhorst, H. Jöstlein, N. Oshima, Daniel Bloch, Dugan O'Neil, E. G. Zverev, T. Yasuda, Elizaveta Shabalina, Emily Nurse, Elizabeth Gallas, T. McMahon, A. Boehnlein, A. Patwa, Denis Gelé, J. N. Butler, N. M. Cason, R. W. Moore, E. Popkov, Daria Zieminska, R. D. Schamberger, H. Dong, L. S. Vertogradov, Frank Filthaut, M. B. Przybycien, J. Ellison, A. K.A. Maciel, P. D. Grannis, Neeti Parashar, T. C. Bacon, K. Del Signore, M. Diesburg, J. Torborg, Y. Jiang, B. Connolly, M. C. Cousinou, M. Jaffré, G. Briskin, David Colling, Sa. Jain, S. Fuess, M. Zielinski, K. M. Chan, Christian Zeitnitz, W. Kahl, C. Han, N. Wallace, T. R. Wyatt, M. A. Kubantsev, T. Kurca, W. L. Prado Da Silva, S. Chopra, Marc Weber, A. Yurkewicz, V. Buescher, J. Gardner, Q. Z. Li, D. K. Cho, Y. Arnoud, I. Ripp-Baudot, S. Greder, Iain Alexander Bertram, Pushpalatha C Bhat, D. Evans, D. Buchholz, D. Casey, Walter Freeman, Meenakshi Narain, Sherry Towers, Jeffrey F. Krane, M. Doidge, A. Meyer, S. W. Youn, Michael Rijssenbeek, D. Mihalcea, C. De Oliveira Martins, P. N. Ratoff, Abdenour Lounis, Ariel Schwartzman, Reiner Hauser, Arnaud Lucotte, M. A.C. Cummings, Melissa Ridel, J. Kotcher, S. Anderson, P. Bonamy, S. Baffioni, A. Kouchner, Harald Fox, D. A. Stoyanova, Alexander Kupco, W. E. Cooper, A. Leflat, B. Hoeneisen, Lee Sawyer, D. Skow, T. Nunnemann, B. Baldin, A. S. Turcot, R. L. McCarthy, M. Lynker, X. F. Song, Christos Leonidopoulos, B. Vachon, P. M. Tuts, V. E. Kuznetsov, R. Kehoe, D. R. Claes, Gavin Davies, W. M. Van Leeuwen, J. A. Parsons, Sebastian Grinstein, Marcel Vreeswijk, Zeno Dixon Greenwood, S. Tentindo-Repond, P. Tamburello, D. A. Wijngaarden, Johannes Elmsheuser, J. Lazoflores, Florian Beaudette, Y. D. Mutaf, I. A. Vasilyev, P. M. Perea, T. Toole, Marumi Kado, J. T. Eltzroth, P. Neustroev, S. Doulas, Emanuela Barberis, Kazunori Hanagaki, Dongliang Zhang, S.A. Kahn, H. E. Fisk, Anna Goussiou, Michael Begel, V. N. Evdokimov, Eduardo De Moraes Gregores, Shuichi Kunori, I. Hall, A. Chandra, Arnaud Duperrin, M. Hohlfeld, J. Womersley, Wendy Taylor, G. Hesketh, Philip Baringer, K. Bos, Marc Besancon, J. Temple, W. M. Lee, A. Kharchilava, Randy Ruchti, R. Jesik, V. M. Korablev, S. Jabeen, Cris W. Barnes, S. Banerjee, S. Lager, T. H. Burnett, Z. Zhou, M. Demarteau, K. A. Johns, A. Bischoff, Carmen García, J. Wittlin, K. Gounder, J. R. Kalk, M. Wobisch, Sergio F Novaes, Boris Tuchming, Cristina Galea, Aran Garcia-Bellido, S. Uvarov, H. L. Melanson, M. P. Sanders, M. Wegner, O. Kouznetsov, Andre Sopczak, M. Buehler, S. Söldner-Rembold, Charles Leggett, S. Chakrabarti, Xiuping Li, N. R. Stanton, Kaushik De, J. Dyer, S. J. De Jong, F. Charles, G. Geurkov, Sergey Kuleshov, B. Andrieu, Jong-Sung Yu, Marvin Johnson, M. Warsinsky, Yurii Maravin, A. V. Kozelov, B. Quinn, Gregory R Snow, Elliott Cheu, Victor Daniel Elvira, Vladimir Gavrilov, Stephanie Beauceron, D. Karmanov, A. Zatserklyaniy, Gordon Watts, B. Kothari, Tulika Bose, K. W. Merritt, V. Sirotenko, M. Gao, Makoto Tomoto, B. Thooris, L. Coney, M. Verzocchi, Thomas Trefzger, R. J. Madaras, A. C. Le Bihan, M. Cristetiu, David H. Adams, Alice Bean, I. Blackler, Jf Renardy, S. E.K. Mattingly, Graham Wilson, D. Chapin, O. V. Eroshin, Y. Song, H. Haggerty, J. Coss, G. Savage, X. Meng, L. Phaf, Phillip Gutierrez, F. Canelli, N. Oliveira, Vipin Bhatnagar, H. da Motta, G. D. Alexeev, Flera Rizatdinova, George Alverson, Sudhir Malik, Ia Iashvili, Michael Martens, N. Lahrichi, Frederic Deliot, Juan Estrada, U. Bassler, R. Zitoun, D. Hedin, R. Illingworth, R. Partridge, X. Zhang, Christian Autermann, M. A. Strang, A. S. Ito, Jean-Roch Vlimant, Jan Stark, Rodney Walker, Regina Demina, Y. M. Kharzheev, Frank Fiedler, S. N. Fatakia, Jaebeom Park, V. M. Podstavkov, Patrick Slattery, M. Merkin, C. S. Mishra, D. Fein, V. L. Malyshev, J. Rha, D. Chakraborty, G. J. Otero y Garzón, Henry Lubatti, Christian Schmitt, S. Nelson, M. H.G. Souza, H. S. Mao, S. N. Ahmed, M. Fortner, N. W. Reay, E. Thomas, E. Kajfasz, H. Weerts, Z. M. Wang, R. Gelhaus, H. E. Montgomery, Alberto Santoro, J. G.R. Lima, T. Christiansen, Bobby Samir Acharya, H. A. Neal, D. Meder, Y. Hu, M. Binder, Don Lincoln, Erich Varnes, P. W. Balm, P. Rubinov, J. T. Linnemann, V. Sorín, Laurent Chevalier, Raymond Brock, Boaz Klima, K. Yip, N. Xuan, S. Sengupta, L. Stutte, Daniel Whiteson, A.S. Dyshkant, Stephen Wimpenny, C. Hebert, J. F. Bartlett, P.F. Ermolov, R. Beuselinck, Martin Grunewald, A. R. Clark, V. White, V. Oguri, A. Koubarovsky, G. S. Muanza, T. Marshall, Milos Lokajicek, J. Hays, Darien Wood, Gustaaf Brooijmans, Zhenbin Wu, Nicholas John Hadley, V. Manankov, J. Warchol, Scott Snyder, M. Agelou, Jing Li, Yu-tin Huang, L. Duflot, Nikos Varelas, Bing Zhou, N.V. Mokhov, B. Åsman, M. I. Martin, A. P. Heinson, R. E. Hall, S. Krzywdzinski, A. Zylberstejn, F. Lehner, H. Greenlee, B. C.K. Casey, Sergey Burdin, A. Bross, G. A. Davis, Serban Protopopescu, S. P. Denisov, Kyoung-Ho Kim, Andy Haas, M. R. Krishnaswamy, G. Alkhazov, Markus Klute, Emmanuel Busato, J. Zhu, Kristian Harder, D. Cutts, Wagner Carvalho, Greg Landsberg, P. K. Mai, Pedrame Bargassa, K. Soustruznik, F. Borcherding, G. Sajot, Miguel Mostafa, Sarah Catherine Eno, François Fleuret, F. Nang, Richard B. Lipton, A. Baden, G. C. Blazey, Y. Yen, B. Zhang, R. Yamada, Jean-Francois Grivaz, S. H. Ahn, P. de Jong, P. Jonsson, M. Mulders, L. Han, C. Luo, Mary Beth Adams, James C. Green, R. Van Kooten, M. D. Corcoran, J. Bystricky, G. Graham, A. Zieminski, J. Huang, R. A. Sidwell, Tiefu Zhao, G. Steinbrück, T. Wlodek, K. Genser, Ulrike Blumenschein, P. L.M. Podesta-Lerma, Jean-Laurent Agram, Brad Abbott, Pierre Petroff, and Y. Coadou
Subjects: Physics, Particle physics, Muon, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Tevatron, General Physics and Astronomy, 7. Clean energy, 01 natural sciences, Lepton number, Lower limit, Nuclear physics, Pair production, 0103 physical sciences, Higgs boson, High Energy Physics::Experiment, Fermilab, 010306 general physics, Boson
Abstract: A search for pair production of doubly charged Higgs bosons in the process p (p) over bar -->H++H---->mu(+)mu(+)mu(-)mu(-) is performed with the D0 run II detector at the Fermilab Tevatron. The analysis is based on a sample of inclusive dimuon data collected at an energy of roots=1.96 TeV, corresponding to an integrated luminosity of 113 pb(-1). In the absence of a signal, 95% confidence level mass limits of M(H-L(+/-+/-))>118.4 GeV/c(2) and M(H-R(+/-+/-))>98.2 GeV/c(2) are set for left-handed and right-handed doubly charged Higgs bosons, respectively, assuming 100% branching into muon pairs.
Published: 2004
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44. [Safeguarding the respiratory tract with the laryngeal mask in pediatric anesthesia--general aspects and new features of the Proseal laryngeal mask airway]

Author: K, Goldmann
Subjects: Respiratory System, Humans, Anesthesia, Inhalation, Child, Laryngeal Masks
Published: 2004

45. [Can sevoflurane save time in routine clincal use? A comparison with halothane in pediatric anesthesia]

Author: K, Hahnenkamp, K, Goldmann, O, Thomas, and U, Braun
Subjects: Methyl Ethers, Sevoflurane, Time Factors, Adolescent, Monitoring, Intraoperative, Anesthetics, Inhalation, Humans, Electroencephalography, Anesthesia, Inhalation, Child, Halothane, Laryngeal Masks
Abstract: The volatile agent sevoflurane enables a rapid emergence from anaesthesia. The aim of this study was to investigate the possibility of increasing turnover in pediatric anaesthetic cases by use of sevoflurane in comparison with halothane. Often short cases or day cases need rapid turnover.The pediatric patients aged 4-14 years (ASA I) presenting for elective ophthalmic surgery were randomised to either the halothane or the sevoflurane group. Standard monitoring was applied to all patients, in addition the pEEG was used to determine comparable anaesthetic depth. Sevoflurane or halothane were titrated to a SEF 90 of 8-12 Hz. Management of the airway was done with the RLMA (reinforced laryngeal mask). All patients were under controlled ventilation. At the end of surgery and anaesthesia 3 time intervals were measured: phase I) end of anaesthetic application--start of spontaneous respiration; phase II) start of spontaneous respiration--removal of RLMA. The SEF 90 interval was also assessed.18 cases were included (halo n = 8/sevo n = 10, no significant differences concerning weight, age, anaesthesia time). There is a significant advantage for the Sevoflurane group in phase II of 6.8 minutes. No differences were seen in phase I and SEF 90 interval.Sevoflurane offers the potential for shortening turnover in pediatric anaesthesia.
Published: 1998

46. Monitoring of Hematopoietic Chimerism by Real-Time Quantitative PCR of Single Nucleotide Polymorphisms In Samples with Low DNA Quantities

Author: Elmira Tomova, Julia Winkler, Wolf Roesler, Andreas Mackensen, Bernd M. Spriewald, K Goldmann, Birgit Lauer, and Christian Bach
Subjects: education.field_of_study, medicine.medical_treatment, Immunology, Population, Single-nucleotide polymorphism, Cell Biology, Hematology, Hematopoietic stem cell transplantation, Biology, Biochemistry, Molecular biology, law.invention, chemistry.chemical_compound, Real-time polymerase chain reaction, chemistry, law, medicine, Microsatellite, SNP, education, Polymerase chain reaction, DNA
Abstract: Abstract 3491 Novel methods to quantify chimerism after allogeneic hematopoietic stem cell transplantation (HSCT) based on single-nucleotide polymorphism (SNP) specific real-time quantitative polymerase chain reaction (qPCR) require high amounts of input DNA. The applicability of these methods in cases where DNA quantity is limiting, however, is currently unclear. Here, we demonstrate that SNP typing performed with just 5ng of input DNA still allowed for the distinction of positive (mean ct 28.05) and negative (ct > 36) signals. In addition, we confirm the high informative value of a set of 19 SNP markers, with 12 markers exceeding 20% informativity in our population (n=74). Of interest, a four-fold reduction of input DNA for qPCR standard curves did not alter PCR efficiencies. Most importantly, in 7 out of 16 allogeneic HSCT patients who experienced disease relapse, a retrospective analysis using the SNP-qPCR method revealed re-appearance of recipient chimerism earlier (mean 95 days) compared to previous results obtained by a short tandem repeat (STR) specific PCR. Taken together our data clearly demonstrate that SNP-qPCR is more sensitive compared to the widely used STR-PCR even with reduced amounts of input DNA. We therefore recommend that SNP-qPCR is preferable to STR-PCR for chimerism analysis in cases where DNA quantity is a limiting factor. Disclosures: No relevant conflicts of interest to declare.
Published: 2010
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47. MODULATION OF ACUTE AND CHRONIC ALLOGRAFT REJECTION VIA ORAL APPLICATION OF ALLOANTIGEN CODING DNA

Author: Bernd M. Spriewald, K Goldmann, A. Bushell, Michael Weyand, and S.M. Ensminger
Subjects: Transplantation, chemistry.chemical_compound, chemistry, business.industry, Modulation, Allograft rejection, Immunology, Medicine, Oral application, business, DNA, Coding (social sciences)
Published: 2008
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48. 420: Modulation of Acute and Chronic Allograft Rejection Via Oral Application of Alloantigen Coding DNA

Author: M. Wollin, Michael Weyand, A. Bushell, K Goldmann, Stephan M. Ensminger, and Bernd M. Spriewald
Subjects: Pulmonary and Respiratory Medicine, Heart transplantation, Transplantation, medicine.diagnostic_test, business.industry, medicine.medical_treatment, hemic and immune systems, chemical and pharmacologic phenomena, Context (language use), Tissue Graft, Flow cytometry, Immune system, Immunology, medicine, Cytotoxic T cell, Surgery, IL-2 receptor, Cardiology and Cardiovascular Medicine, business, Pravastatin, medicine.drug
Abstract: Purpose: Post transplant hyperlipidaemia is associated with the development of coronary graft vasculopathy (CGV). Statins are frequently used in this context, with evidence showing that they reduce the burden of CGV. In addition to lipid lowering properties, statins also have pleiotropic properties including anti inflammatory effects and beneficial immunomodulatory effects on cytotoxic T cells. However, their effect on T regulatory cells (Tregs) which induce transplant tolerance, has yet to be elucidated. Methods and Materials: 96 stable heart transplant patients undergoing routine venesection were prospectively studied. Pravastatin use in each patient was determined by clinical necessity as judged by the caring physician. Flow cytometry and software generated gating strategies were used to identify subdivisions of circulating lymphocytes. Results: 45 patients received Pravastatin, with the remaining 51 patients used as controls. There were no differences in clinical or demographic characteristics between the two groups. For patients taking Pravastatin, the numbers of Tregs were significantly reduced in comparison to controls. These included CD25 cells (P 0.004), CD4 CD25 cells (P 0.002) and CTLA-4CD25 cells (P 0.002). The number of circulating CD4 cells without regulatory markers did not differ between groups. As the dose of Pravastatin increased, the number of Treg cells decreased (CD25; P 0.046, CD4 CD25; P 0.04, CTLA-4 CD25; P 0.04). Conclusions: Pravastatin was associated with lower numbers of circulating Treg cells in patients following heart transplantation. This might alter recipient immune responses to graft tissue, as Treg cells suppress allospecific CD4 T cell responses.
Published: 2008
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49. Endotracheal intubation through the intubating laryngeal mask in children: video-endosocopic findings and guidance

Author: C. Dillier, U. Schwarz, Markus Weiss, K. Goldmann, and Andreas C. Gerber
Subjects: Anesthesiology and Pain Medicine, business.industry, Anesthesia, Medicine, Endotracheal intubation, business
Published: 2000
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50. Videolaryngoskopie zur modifizierten „Rapid-sequence-Narkoseeinleitung“.

Author: K. Goldmann, G. Kalmus, T. Steinfeldt, I. Friedrich, and H. Wulf
Published: 2006

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164 results on '"K. Goldmann"'

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