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1. Chlamydia pneumoniae antibodies are associated with an atherogenic lipid profile

Author

G. M. L. Ong, Dermot O'Reilly, Liam J. Murray, Alun Evans, K. B. Bamford, and Ciaran O'Neill

Subjects
Adult, Male, Population, Myocardial Ischemia, Physiology, World Health Organization, chemistry.chemical_compound, High-density lipoprotein, Humans, Medicine, Risk factor, education, education.field_of_study, Chlamydia, medicine.diagnostic_test, business.industry, Cholesterol, Incidence, Incidence (epidemiology), Cholesterol, HDL, Chlamydophila pneumoniae, Middle Aged, medicine.disease, Antibodies, Bacterial, Lipids, Cross-Sectional Studies, chemistry, Immunoglobulin G, Chronic Disease, Papers, Immunology, Female, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, business, Lipid profile, Body mass index, Biomarkers
Abstract

OBJECTIVE—To determine, within a representative population group of men and women, whether alteration of the lipid profile might underlie the reported association between Chlamydia pneumoniae and ischaemic heart disease. DESIGN AND SETTING—Cross sectional survey in an area with a high incidence of ischaemic heart disease. SUBJECTS—400 randomly selected participants in the World Health Organisation MONICA project's third population survey in Northern Ireland. MAIN OUTCOME MEASURES—Stored sera were examined by microimmunofluorescence for IgG antibodies to C pneumoniae at a dilution of 1 in 64. Mean total and high density lipoprotein (HDL) cholesterol were compared between seropositive and seronegative individuals with adjustment for age, measures of socioeconomic status, smoking habit, alcohol consumption, body mass index, and the season during which blood had been taken. RESULTS—In seropositive men, adjusted mean serum total cholesterol and HDL cholesterol were 0.5 mmol/l (9.2%) higher and 0.11 mmol/l (9.3%) lower, respectively, than in seronegative men. Differences in women did not achieve statistical significance, but both total cholesterol and HDL cholesterol were higher (3.6% and 5.8%, respectively) in seropositive than in seronegative individuals. CONCLUSIONS—There is serological evidence that C pneumoniae infection is associated with an atherogenic lipid profile in men. Altered lipid levels may underlie the association between C pneumoniae and ischaemic heart disease. Keywords: epidemiology; lipids; cholesterol; ischaemic heart disease

Published
1999
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2. Irish society of gastroenterology

Author

B. M. Ryan, S. McKiernan, P. W. N. Keeling, P. J. Byrne, R. Quill, K. McCallion, R. M. S. Mitchell, R. G. P. Watson, J. S. A. Collins, K. R. Gardiner, D. C. Winter, G. C. O’Sullivan, C. T. Taylor, N. F. Fanning, H. P. Redmond, D. P. O’Donoghue, A. W. Baird, B. J. Harvey, A. E. Brannigan, P. R. O’Connell, M. C. Regan, J. M. Fitzpatrick, R. W. G. Watson, H. Lemass, E. Ryan, P. MacMathuna, J. Crowe, J. C. O’Keane, J. Goh, A. Baird, L. Maher, C. Godson, H. R. Brady, N. A. Petasis, V. V. Fokin, M. K. Barry, D. C. Grant, K. Sheahan, J. M. P. Hyland, K. M. Sheehan, D. J. Fitzgerald, F. E. Murray, A. Heaney, K. B. Bamford, R. J. McFarland, T. C. K. Tham, D. McNamara, S. Franelli, H. Whelan, H. Hamilton, S. Beattie, C. O’Morain, E. G. Brennan, N. O’Hare, R. McDermott, N. I. McDougall, C. M. Gieeson, S. E. H. Russell, J. M. Sloan, D. Morrisey, L. Murphy, B. Kiely, G. Fitzgerald, C. Daly, G. O’Sullivan, F. Shanahan, J. K. Collins, P. Marteau, S. D. Johnston, C. Coates, C. Feighery, J. O’Keeffe, A. Whelan, S. Lynch, D. G. Weir, M. Abuzakouk, L. Barnes, N. O’Gorman, M. McKenna, R. Freaney, M. Young, S. Gaines, D. Brady, D. Drudy, C. O’Farrelly, A. Gilleece, L. Fenelon, J. McPartlin, A. M. Hopkins, A. Myers, P. Moynagh, J. M. Kirby, M. J. Allen, B. Best, H. Calvert, S. Kirk, S. T. D. McKelvey, R. J. Moorehead, J. C. Varghese, S. Sookhai, T. Walsh, H. Osborne, P. Broe, M. J. Lee, D. Moriarty, R. Coffey, E. Murphy, A. A. Shah, E. Murray, B. Thjodleifsson, I. Bjarnason, S. Montague, C. Forkin, G. C. O’Toole, C. M. Gallagher, P. Connell, O. Traynor, T. C. Ling, B. Johnston, M. F. Byrne, M. A. Farrell, C. A. Goulding, S. S. Albloushi, P. O’Connell, L. E. Graham, T. J. Robinson, T. Jabeen, B. Cannon, D. Jenkins, M. J. Whelton, S. Bohra, C. Keohane, M. Duggan, R. K. Siddheshwar, R. G. Wilson, P. J. Hainsworth, F. C. Campbell, S. B. Kelly, B. M. Egan, C. Simutowe, D. A. McNamara, N. Collins, T. N. Walsh, A. Mukherjee, M. Scott, C. Pohl, E. Duggan, M. Wasi, A. Sarkar, L. O. Donnell, P. W. Eustace, J. G. Johnston, R. Waldron, S. Barrett, G. Callagy, J. C. O. Keane, B. Coughlan, J. Sheehan, A. Hickey, A. Carr, M. R. Kell, M. Lynch, D. Ryan, P. Rajpal, W. O. Kirwan, C. J. Larkin, J. E. S. Ardill, K. D. Buchanan, P. L. Lim, M. Gibbons, E. J. Crawford, B. T. Johnston, C. Rodgers, S. Johnston, B. M. Crone, A. H. G. Love, L. Feighery, J. Jackson, M. M. I. Yassin, D. W. Harkin, A. A. B. Barros D’sa, T. G. Parks, M. P. Curry, J. E. Hegarty, L. Golden-Mason, E. Hannigan, and N. Parfrey

Subjects
medicine.medical_specialty, Pediatrics, Irish, business.industry, Family medicine, medicine, language, General Medicine, business, language.human_language
Published
1998
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3. Irish society of gastroenterology

Author

G. Clarke, E. Ryan, J. C. O’Keane, J. Crowe, P. McMathuna, D. Moriarty, R. Ettarh, K. Sheahan, J. Hyland, D. P. O’Donoghue, A. W. Baird, G. Gormley, J. C. O. Keane, P. MacMathuna, J. H. Wang, Q. D. Wu, H. P. Redmond, C. Condron, D. Bouchier-Hayes, K. Nally, F. Newton, J. O’Connell, G. C. O’Sullivan, J. Morgan, J. K. Collins, F. Shanahan, C. Goode, D. C. Winter, C. T. Taylor, M. M. Skelly, B. J. Harvey, J. C. Varghese, M. A. Farrell, F. P. McGrath, F. E. Murray, H. Osborne, M. J. Lee, A. Sullivan, A. E. Ryan, A. N. Donovan, P. A. McCormick, B. Kenny, S. Somers, A. Bohan, R. G. Gibney, M. Marcaccio, D. E. Malone, M. Doyle, C. P. Delaney, T. F. Gorey, G. P. McEntee, A. Clarke, R. Stuart, J. Kelly, M. D. Kiely, M. O’Sullivan, E. Lovett, N. Mahmud, D. Kelleher, C. A. O’Morain, C. J. Larkin, R. G. P. Watson, J. M. Sloan, J. E. S. Ardill, C. F. Johnston, K. D. Buchanan, A. Heaney, J. S. A. Collins, G. R. P. Watson, R. M. Kalin, T. C. K. Tham, R. J. McFarland, K. B. Bamford, T. Ó Cróinín, M. Clyne, B. Drumm, M. Rowland, D. Kumar, P. O’Connor, L. E. Daly, D. L. O’Toole, A. Long, A. M. Murphy, L. O’Neill, D. G. Weir, A. M. Hopkins, P. Moynagh, C. Brennan, J. Harmey, P. P. Stapleton, A. M. Rasheed, G. Chen, C. Kelly, D. J. Bouchier-Hayes, A. Leahy, M. Gallagher, A. Grace, Y. Xin, M. Leader, E. Kay, A. Whelan, U. Pattison, R. Willoughby, E. Wallace, D. Weir, C. Feighery, M. W. Bennett, C. Brady, D. Roche, A. Molloy, J. McPartlin, J. M. Scott, A. G. Acheson, J. Lee, K. Khosraviani, S. T. Irwin, J. McDaid, J. R. Docherty, A. O’Grady, M. Mabruk, C. Johnston, W. Curry, J. Ardill, R. Cunningham, N. I. McDougall, P. V. Coyle, M. E. Callender, A. M. Ouinn, R. Warner, F. M. Stevens, P. I. S. Chakravarthi, M. Kearns, M. Bourke, A. Hassan, J. McWeeney, C. F. McCarthy, M. Casey, J. O’Donoghue, A. M. Eustace-Ryan, P. O’Regan, L. Feighery, J. Jackson, N. Cronin, K. Quane, E. D. Mulligan, T. Purcell, B. Dunne, M. Griffin, N. Noonan, D. Hollywood, N. Keeling, J. V. Reynolds, T. P. J. Hennessy, M. O’Sulhvan, I. Harman, N. P. Breslin, N. Clayton, S. Hogan, B. Donovan, D. Hayes, M. Kiely, C. A. Goulding, S. S. Albloushi, J. O’Connor, M. G. Courtney, D. Royston, A. G. Shattock, A. Stack, M. Carmody, S. Barrett, A. Hennigan, L. Young, C. J. Shields, C. O’Keane, J. M. Fitzpatrick, M. M. Doyle, R. B. Stephens, P. A. Daly, G. M. Briggs, D. McCrory, S. O’Neill, H. O’Grady, D. C. Grant, K. Barry, O. Traynor, J. M. P. Hyland, G. C. O’Toole, M. K. Barry, S. D. Johnston, C. M. Ritchie, T. J. Robinson, J. M. Kirby, E. M. Mackle, N. Haider, N. Aherne, F. McNichol, D. Hamilton, P. Neary, S. Hegarty, J. O. Connor, R. G. K. Watson, D. Drudy, A. Alwan, L. Fenelon, C. O’Farrelly, B. Byrne, L. Madrigal, J. Carton, C. Collins, D. O’Donoghue, N. Gannon, A. Hickey, C. A. O’Boyle, R. Byrne, S. Albloushi, and F. Murray

Subjects
medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Library science, Medicine, General Medicine, business, language.human_language
Published
1998
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4. Epidemiology of Helicobacter pylori infection among 4742 randomly selected subjects from Northern Ireland

Author

E E McCrum, K. B. Bamford, Alun Evans, and Liam J. Murray

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Alcohol Drinking, Epidemiology, Population, Northern Ireland, Body Mass Index, Helicobacter Infections, Serology, Random Allocation, Sex Factors, Risk Factors, Internal medicine, Prevalence, Humans, Medicine, Serologic Tests, Risk factor, Child, education, education.field_of_study, Helicobacter pylori, biology, business.industry, Smoking, Age Factors, General Medicine, Odds ratio, Middle Aged, biology.organism_classification, Health Surveys, Body Height, Confidence interval, Social Class, Immunology, Female, business, Body mass index
Abstract

Background. Despite the widespread prevalence and serious clinical sequelae of infection with Helicobacter pylori, there have been few large population-based studies, using randomly selected subjects, examining the epidemiology of this infection. Aim. To examine the distribution and determinants of H. pylon infection in a developed country. Subjects and Setting. Overall 4742 subjects, aged 12-64, from Northern ireland were randomly selected. Methods. Helicobacter pylori specific IgG antibodies were measured by enzyme linked immunosorbent assay, using an acid-glycine extract antigen, in stored serum from subjects who had participated in three linked population-based surveys of cardiovascular risk factors performed in 1986 and 1987. Results. The overall prevalence of H. pylori infection was 50.5%. Prevalence increased with age from 23.4% in 12-14 year olds to 72.7% in 60-64 year olds: chi(2) for trend 518, P < 10(-4). In subjects aged greater than or equal to 25, infection was more common in males (60.9%) than females (55.2%):;chi(2) = 9.53, P < 0.01. This relation remained significant after adjusting for age, and measures of socioeconomic class: odds ratio (OR) for infection, male versus female was 1.19 (95% confidence interval [CI] : 1.02-1.40). infection was associated with social class: the adjusted OR of infection in subjects from manual social classes relative to those from non-manual classes was 1.7 (95% Ci : 1.47-1.98). Infection was significantly more common in current smokers and ex-smokers than in subjects who had never smoked: adjusted OR for infection, ex-smokers versus never smoked was 1.22 (95% CI : 1.01-1.49); for smokers of greater than or equal to 20/day versus never smoked OR = 1.33 (95% CI:1.05-1.67). Infection was not associated with height in adult males but mean height in infected women was lower than in uninfected women after adjusting for age and socioeconomic status: difference in mean height (SE), -0.85 cm (0.32), P < 0.01. There was no demonstrable relationship between H. pylori infection and current alcohol intake. Conclusions. This study demonstrated a high prevalence of infection in a population from a developed country. Previously reported associations between H. pylori infection, age, sex, social class, and reduced height in females were confirmed and smoking was identified asa possible risk factor for H. pylori infection.

Published
1997
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5. Irish Society of Gastroenterology

Author

D. F. Smith, N. Leonard, Michael J. Kerin, Brian J. Harvey, M. Duggan, Jiang Huai Wang, S. McDonald, J. S. A. Collins, Malachi J. McKenna, Frank B. V. Keane, Cormac T. Taylor, E. Mulligan, C. Kelly, N. Fanning, M. G. Goggins, David Bouchier-Hayes, W. A. Tanner, T. Hogan, F. Barker, S. Keating, B. T. Johnston, W. R.F. Ferguson, G. Thornton, Oliver J. McAnena, Colm O'Morain, G. P. McEntee, U. Srinivasan, K. B. Bamford, Alan W. Baird, Éanna J Ryan, O. Crosbie, A. Whelan, J. Crowe, Simon Keely, Terry Boyle, A. Pryde, J. Carton, Derek Moriarty, F. O’Brien, Niall Breslin, M. O’Riordain, S. Montague C. O'Morain, B. Crowley, N. McCallion, K. Synnott, D. P. O'Donoghoe, N. A. Parfrey, P. McEneaney, P. MacMathuna, Claire Condron, M. K. Barry, D. P. O’Donoghue, S. Doyle, T. P. J. Hennessy, Henry Paul Redmond, S. Beattie, J. M. Sloan, T. N. Walsh, J. K. Collins, M. Casey, R. B. Mooney, O. P. Clinton, M. A. Stokes, Cliona O'Farrelly, John M. Fitzpatrick, Dermot Kelleher, K. F. McGeeney, S. Duggan, I. Frazer, C. Feighery, H. Hamilton, A. G. Shattock, C. McCormick, Diarmuid O'Donoghue, P. McGurgan, G. O'Sullivan, K. C. Trimble, X. J. Fan, Thomas F. Gorey, P. R. O'Connell, D. Carroll, N. Mahmud, Margaret O'Mahony, G. Kelly, N. I. McDougall, T. C. K. Tham, L. Madrigal, Javed Yakoob, Peter J. Kelly, S. Douglas, R. C. Heading, J. Quinn, Gerald C. O'Sullivan, P. Lawlor, J. P. O'Donoghue, D. Maguire, Andrew H.G. Love, D. Booth, D. J. Reen, M. M. Skelly, D. Graham, E. M. Murray, Paul G. Horgan, F. Campbell, J. F. Fielding, X. G. Fan, K. Mealy, Donald G. Weir, R. Merriman, A. Long, R. C. Stuart, A. Keaveny, M. G. O'Sullivan, A. E. Brannigan, J. M. O≿donoghue, C. Morrison, A. Conroy, R. J. McFarland, S. Sachithanandan, Rosemarie Freaney, J. Lennon, Patrick J. Byrne, S. Al-Bloushi, P. Gillen, J. P. McGrath, G. S. A. McDonald, A. Weerkamp, R. G. P. Watson, C. Scanlon, P. W. N. Keeling, J. Hegarty, Maria M. Buckley, J. Mathias, M. C. Regan, Fergus Shanahan, R. W. G. Watson, K. Barry, M. G. Courtney, and Suzanne Norris

Subjects
medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Medicine, Library science, General Medicine, business, language.human_language
Published
1994
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6. Irish society of gastroenterology

Author

M. C. Prabhaker, D. Coll, J. S. A. Collins, M. T. P. Caldwell, Madeleine Ennis, W. P. Joyce, A. M. O’Mahony, J. A. O’Donnell, H. E. Mulcahy, R. A. Smallwood, W. Lamort, J. Fitzpatrick, J. Dias, R. Gibney, K. O’Sullivan, P. W. Angus, A. D K Hill, C. Kelly, J. J. Crosbie, T. Gorey, J. O’Connell, J. M. P. Hyland, N. McLaughlin, E. Kay, C. Boreham, P. Kent, M. Madden, C. Hardiman, D. McCrory, J. Dolan, Marguerite Clyne, J. Burke, T. Corrigan, Paul E. Burke, C. Barry Walsh, P. D. Carey, S. Sant, P. Broe, M. Duggan, Kevin O'Malley, J. Crowe, M. J. Ryan, Henry Paul Redmond, C. A. Bannon, W. O. Kirwan, R. H. Wilson, J. Gilvarry, Mohamed Abuzakouk, S. Jazrawi, M. M. Skelly, D. Gillmore, Patrick J. Byrne, R. Alvi, James O'Donnell, A. Chong, M. G. Goggins, C. F. Johnston, S. Kee, M. O’Brien, Davina Fillmore, H. Hamilton, C. F. McCarthy, Colm O'Morain, P. W. N. Keeling, J. Jackson, T. N. Walsh, C. N. Shahi, G. T. McGreal, H. Y. Browne, P. Keeling, J. F. Fielding, David Bouchier-Hayes, H. Li, B. T. Johnston, C. McElearney, G. Lynch, N. Duckham, O. Traynor, E. Casey, C. Maguire, M. McNicholas, C. Feighery, C. H V Hoyle, Martin J. O’Sullivan, K. Williaon, S. M. Norris, R. J. Moorehead, A. Qureshi, S. Beattie, R. J. McFarland, R. G P Watson, G. R. Campbell, Hugh Mulcahy, M. P. Brady, E. Beausang, B. Lane, N. Menzies-Gow, Frank E. Murray, D. Bouchier-Hayes, R. B. Sewell, L. J D O’Donnell, T. Diamond, Donald G. Weir, R. J. Cahill, N. Swan, D. J. Hehir, B. Curran, R. F. McLoughlin, B. Goss, Dermot Kelleher, S. Namnyak, Peter J. Kelly, Pierce A. Grace, J. C. McLoughlin, D. Phelan, T. P. J. Hennessy, C. Hanvajanawong, A. M. O’Connor, N. Willia, Awad El Magbri, K. J. Cronin, C. Prendergast, Fiona M. Stevens, Joy Ardill, M. Buckley, Cliona O'Farrelly, J. K. Collins, K. Mealy, C. M. Reardon, M. Cyne, B. J. Rowlands, L. Joyce, S. Lynch, S. D. O’Broin, J. S. Doyle, R. O’Connell, D. P. MacErlean, J. Carr, E. W. Kay, F. H. Mourad, E. Ogutu, Éanna J Ryan, G. O'Sullivan, K. B. Bamford, H. Osborne, M. I. Halliday, J. E. Hegarty, A. L. Leahy, B. Kelleher, Robert G. Gibney, F. A. O’Connor, Brendan Drumm, S. Mulvey, M. G. Courtney, W. D. B. Clements, M. J G Farthing, B. O’Loughlin, W. S. Monkhouse, J. R T Monson, A. M. Forde, Keith D. Buchanan, John Hyland, Joseph Deasy, G. Thornton, M. Ferguson, S. M. Pender, S. Sheehan, D. D. Weir, Marina A. Lynch, D. P. O’Donoghue, John M. Fitzpatrick, M. Leader, J. Lennon, E. Clarke, George W. Johnston, Diarmuid O'Donoghue, John M. Scott, R. W. Parks, W. Stack, Andrew H.G. Love, Gerald C. O'Sullivan, T. G. Denesh, Nezam H. Afdhal, D. Stafford-Johnson, Thomas F. Gorey, T. C K Tham, D. A. Lutton, H. M. Fenlon, X. J. Fan, D. F. Hughes, M. Goggin, W. A. Stack, A. Chua, E. Mooney, P. MacMathuna, S. T. O’Sullivan, A. Darzi, Conor Patrick Delaney, D. O’Donovan, and M. M J McNicholas

Subjects
medicine.medical_specialty, Irish, business.industry, Family medicine, language, medicine, Optometry, General Medicine, business, language.human_language
Published
1993
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7. Irish Society of Gastroenterology

Author

J. Coleman, D. Bouchier Hayes, M. A. Daw, R. O’More, C. T. Keane, C. O’Morain, G. W. Johnson, E. F. A. Spencer, A. J. Wilkinson, T. L. Kennedy, J. S. A. Collins, K. B. Bamford, B. J. Collins, J. M. Sloan, R. J. Moorehead, A. H. G. Love, C. McCarthy, R. Collins, S. Beattie, J. McDevitt, C. Feighery, C. O’Farrelly, D. G. Weir, D. Kelleher, A. Whelan, Y. Williams, D. Kellegher, D. Weir, M. C. Prabhakar, M. Daw, F. Keane, E. W. M. McDermott, B. Duduric, M. F. Brennan, R. Gaffney, J. O’Leary, T. Doyle, A. Gaffney, D. B. Gough, K. C. H. Fearon, P. Winstanley, D. C. Carter, O. J. McAnena, F. A. Moore, E. E. Moore, R. Pogetti, V. M. Peterson, C. M. Abemathy, P. Parsons, N. N. Williams, J. M. Daly, M. Herlyn, D. Bouchier-Hayes, N. F. Course, P. G. Horgan, A. Fahy, C. Delaney, J. M. Fitzpatrick, T. F. Gorey, S. Jazrawl, T. N. Walsh, P. J. Byrne, P. Lawlor, T. P. J. Hennessy, K. R. O’Sullivan, P. M. Mathias, M. McNicholas, M. Logan, J. Masterson, P. Gillen, J. Hyland, E. Beausang, W. P. Joyce, N. Williams, W. Maxwell, I. Reid, I. Sharpe, J. G. Geraghty, W. A. Tanner, S. Patchett, H. Mulcahy, N. Afdhal, D. O’Donoghue, A. Lohan, A. Darzi, F. B. V. Keane, P. W. N. Keeling, R. C. Gibney, R. Keane, J. Drumm, T. J. Egan, P. V. Delaney, G. O’Sullivan, P. Harte, P. A. Grace, A. Qureshi, H. Osbome, D. J. Bouchier-Hayes, S. L. Bamford, J. Geraghty, F. B. Keane, J. E. Coleman, A. Gleeson, K. Mealy, M. Barry, O. Traynor, J. J. Keating, A. Chua, S. Ah-Kion, J. McNulty, L. G. Heaney, P. Murphy, J. H. Connolly, M. E. Callender, P. MacMathuna, M. Farrant, D. O. B. Hourihane, P. Donaldson, M. Lombard, D. Westaby, Roger Williams, N. F. Couse, J. Burke, G. Lennon, C. P. Delaneyc, S. O’Brien, A. O’Brien, M. X. Fitzgerald, J. E. Hegarty, N. Noonan, M. Healy, R. O’Moore, O. I. Corrigan, P. W. N. Keating, H. U. I. Li, R. C. Stuart, S. Jazrawi, D. Wai, H. Jaeger, A. M. Jackson, C. J. Mitchell, J. MacFie, C. P. Delaney, K. McGeeney, M. T. P. Caldwell, D. P. O’Donoghue, J. Connolly, E. Kay, T. Gorey, P. McKiernan, J. F. T. Glasgow, B. T. Johnson, R. Ferguson, I. Davidson, J. Hurley, P. Keeling, T. Crowley, A. A. Long, D. P. O’Brien, R. P. Waldron, M. J. Shearer, H. F. Given, G. McEntee, J. Monson, J. Donohue, D. Nagomey, K. C. Trimble, A. M. Molloy, J. M. Scott, J. McKeever, and T. P. J. Hennessey

Subjects
Irish, business.industry, language, Medicine, Library science, General Medicine, business, language.human_language
Published
1993
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8. Abstract form for the Irish Journal of Medical Science v workshop on gastroduodenal pathology and Helicobacter pylori July 5th — 7th 1992 — Dublin, Ireland

Author

R. P. H. Logan, P. A. Gummett, M. M. Walker, Q. N. Karim, J. H. Baron, J. J. Misiewicz, G. Trieber, S. Walker, U. Klotz, A. Lozniewski, M. Weber, J. D. de Korwin, J. Floquet, M. C. Conroy, J. C. Burdin, G. A. Mannes, E. Bayerdörffer, W. Höchter, J. Weingart, W. Heldwein, A. Sommer, S. Müller-Lissner, W. Bomschein, S. Miehlke, M. Weinzierl, G. Ruckdeschel, H. von Wulffen, W. Köpcke, M. Stolte, S. J. Rune, T. Justesen, J. M. Hansen, T. G. Jensen, J. Eriksen, O. ø. Thomsen, J. Scheibel, O. Bonnevie, A. Bremmelgaard, M. Vilien, S. Knuhtsen, L. Elsborg, J. Hansen, K. Lauritsen, H. R. Wulff, D. Boixeda, S. Ballestero, R. Cantón, L. De Rafael, C. Martinm de Argila, M. J. Pozuelo, J. Sampedro, F. Baquero, P. Ya. Grigoriev, V. A. Isakov, E. P. Iakovenko, A. M. Hirschl, G. Brandstätter, B. Dragosics, E. Hentschel, M. Kundi, M. L. Rotter, K. Schütze, M. Taufer, M Neri, D Susi, I Bovani, R Pindo, F. Cuccurullo, L. G. V. Coelho, M. C. F. Passos, Y. Chausson, W. L. S. Vieira, F. J. Castro, J. M. M. Franco, M. L. M. Fernandes, L. P. Castro, C. Jonas, E. De Koster, M. Van Gossum, M. Depierreux, M. Cheval, M. Deltenre, E. Schütz, B. Bethke, A. Lee, E. Hegedus, J. O’Rourke, H. Larsson, S. Sjöstedt, B. Veress, C. E. Nord, G. M. Sobala, R. George, D. Tompkins, J. Finlay, A. Manning, S. Sant, H. X. Xia, M. Daw, J. Gilvarry, C. T. Keane, C. O’Morain, M. A. Rubio, B. Hegarty, A. L. Blum, E. Sulser, O. Stadelmann, N. Munoz, E. Buiatti, J. Vivas, W. Oliver, E. Cano, S. Peraza, D. Castro, V. Sanchez, O. Andrade, M. Benz, G. L. Mendz, S. L. Hazell, K. S. Salmela, R. P. Roire, J. Hook-Nikanne, T. U. Kosunen, M. Salaspur, C. J. Luke, D. D. J. Reynolds, C. W. Penn, G. Bode, F. Mauch, H. Ditschuneit, P. Malfertheiner, Richard L. Ferrero, Labigne Agnes, K. A. Eaton, S. Krakowka, H. L. T. Mobley, Li-Tai Hu, P. A. Foxall, A. P. Moran, I. M. Helander, C. Altman, I. Sobhani, C. Vissugaire, M. Migrant, J. P. Etienne, P. Sommi, V. Ricci, R. Fiocca, E. Cova, N. Figura, M. Romano, K. J. Ivey, E. Solcia, U. Ventura, M. Nilius, S. Schieffer, K. J. Hengels, H. Jablonowski, G. Strohmeyer, M. D. Cabrai, A. J. A. Barbosa, G. F. Lima Hr., C. A. Oliveira, J. M. Polak, G. Oderda, L. Villani, F. Altare, I. Morra, L. Miserendino, N. Ansaldi, M. F. Dixon, J. I. Wyatt, A. T. R. Axon, S. Beattie, H. Hamilton, S. Shabib, E. Cutz, B. Drumm, P. Sherman, L. A. Noach, T. Rolf, N. B. Bosma, M. P. Schwartz, J. Oosting, E. A. J. Rauws, G. N. J. Tytgat, A. Andrew, G. Nardone, F. d’Ormiento, M. Pontillo, A. J. Lobo, J. S. Uff, C. N. M. McNulty, S. P. Wilkinson, R. Suriani, C. Pallante, M. Ravizza, D. Galliano, D. Sallio, M. Malandrino, R. Oneglio, M. Colozza, D. Mazzucco, E. Gaia, S. Eidt, P. Vincent, F. Gottrand, D. Turck, M. Lecomte-Houcke, H. Leclerc, F. Bonvicini, S. Pretolani, M. Baraldini, D. Cilla, S. Baldinelli, E. Bazocchi, P. Acampora, N. Careddu, E. Brocchi, G. Gasbarrini, M. Joubert, N. Bazin, D. Thiaucourt, E. Protte, C. Gissler, A. Duprez, P. Merlin, S. Forestier, J. Labenz, E. Gyenes, G. H. Rühl, G. Börsch, G. Daskalopoulos, J. Carrick, R. Lian, S. Wagner, J. Bleck, M. Gebel, W. Bär, M. Manns, H. Lamouliatte, P. H. Bernard, R. Cayla, G. Vialette, A. Quinton, F. Mégraud, M. Lemaire, A. Quinten, A. De Mascarel, P. Webb, D. Forman, T. Knight, A. Wilson, S. Graves, D. Newell, J. Elder, E. Tonelli, M. R. A. Gatte, G. C. Ghironzi, G. Giulianelli, K. B. Bamford, J. S. A. Collins, J. Bickley, B. T. Johnston, S. Potts, V. Boston, R. J. Owen, J. Sloan, L. Basso, S. Lawlor, J. Clune, H. Szelényi, G. Stohmeyer, G. Macedo, I. Iglésias, A. P. Chaves, A. Loureiro, P. H. Katelaris, F. Seow, B. Lin, J. Napoli, D. B. Hones, M. C. Ngu, Natalia S. Akopyantz, Nikolay O. Bukanov, T. Ulf Westblom, Douglas E. Berg, J. F. Nyst, P. Denis, M. Buset, M. De Reuck, H. Nielsen, L. P. Andersen, Sabine Birkholz, Ulrich Knipp, Claudia Nietzki, Wolfgang Opferkuch, J. E. Crabtree, P. Peichl, I. J. D. Lindly, K. Deusch, C. Seifirth, A. Funk, I. Dahie, K. Reut, M. Classen, P. Gionchetti, D. Vaira, M. Campieri, E. Bertinelli, M. Menegatti, A. Belluzzi, C. Briognola, M. Miglioli, L. Barbara, A. Di Tommaso, M. T. De Magistris, M. Bugnoli, R. Petracca, A. Covacci, S. Censini, R. Rappuoli, S. Abrignani, M. C. Territo, K. L. Smela, J. R. Reeve, T. D. Lee, J. H. Walsh, D. Armellini, Z. Y. Xiang, H. M. Mitchell, P. J. Hu, Y. Y. Li, Z. J. Wang, S. M. Zhao, Q. Liu, M. Chen, G. G. Du, M. I. Filipe, P. I. Reed, M. E. Craanen, P. Blok, W. Dekker, E. Colombo, D. Redaelli, M. Santangelo, M. Spinelli, F. Farinati, F. Valiante, G. Delia Libera, B. Germanà, R. Baffa, M. Rugge, F. Vianelo, F. Di Mario, Pentti Sipponen, T. Rokkas, G. Popotheodorou, N. Kaldgeropoulos, C. Deprez, P. Galand, J. G. Fox, P. Wishnok, J. C. Murphy, S. Tannenbaum, P. Correa, Julie Parsonnet, C. Macor, G. L. Da Broi, C. Avellinio, R. Reifen, I. Rasooly, M. E. Millson, K. Murphy, J. E. Thomas, E. J. Eastham, E. Malorgio, D. Dell’Olio, T. P. Kemmer, J. E. Dominguez-Munoz, H. Klingel, M. R. A. Gatto, R. Olivieri, R. F. Bayeli, L. Abate, L. De Gregorio, J. Aziz, E. Esposito, C. Basagni, R. Guilluy, M. Rousseau-Tsangaris, J. L. Brazier, Torkel Wadstiöm, Tadeusz Tyszkiewicz, Per Bergenzaun, Karin Olsson, C. Birac, F. Tall, M. Albenque, A. Labigne, F. Megraud, R. A. Feldman, J. Deeks, Y. Glupczynski, A. Burette, H. Goossens, C. Van den Boore, J. P. Butzler, S. Veldhuyzen van Zanten, L. Best, G. Benzanson, D. Haldane, S. Hazell, N. P. Mapstone, D. A. F. Lynch, P. Quirke, D. E. Taylor, N. Chang, M. Eaton, E. Stockdale, S. M. Salama, L. Thompson, A. Cockayne, R. C. Spiller, E. Leen, E. Sweeney, H. Klann, R. Hatz, W. Bornschein, T. Simon, A. Eimiller, F. Bolle, C. Schweikert, W. Köpeke, S. F. Moss, A. E. Bishop, J. Calam, R. J. Cahill, H. Xia, J. Solnick, and L. Tompkins

Subjects
0303 health sciences, medicine.medical_specialty, biology, 030306 microbiology, business.industry, General surgery, General Medicine, Helicobacter pylori, biology.organism_classification, language.human_language, Duodenal ulcer, 03 medical and health sciences, Irish, language, Medicine, Optometry, Gastritis, medicine.symptom, business, Medical science, 030304 developmental biology
Published
1992
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9. Irish society of gastroenterlogy

Author

R. G. P. Watson, B. M. Bhatt, K. G. Porter, C. Doherty, C. McCaughey, T. S. Wilson, D. F. Hughes, J. D. Biggart, C. L. Little, G. C. Corbett-Feeney, M. P. G. Little, C. F. McCarthy, G. Kavanagh, S. Kee, J. McNulty, J. F. Fielding, J. Huang, C. Smyth, J. P. Arbuthnott, N. P. Kennedy, A. Chua, P. W. N. Keeling, J. Lappin, P. Gillen, P. Burke, J. Hyland, A. D. Hill, D. P. O’Donoghue, S. J. McGrath, K. D. Buchanan, C. F. Johnston, K. Barry, D. J. Waldron, P. G. Horgan, M. McGuire, H. F. Given, K. B. Bamford, J. S. A. Collins, T. S. Wilson., S. Patchett, T. O’Riordan, E. Leen, C. Keane, C. O’Morain, D. G. Gilroy, E. J. Mackle, R. A. J. Spence, G. W. Johnson, K. R. O’Sullivan, P. M. Mathias, A. Tobin, C. A. O’Morain, M. E. Carson, F. M. Stevens, M. Bourke, M. Kearns, F. Gannon, D. P. O’Donoghue., S. Ah-Kion, M. O’Driscoll, E. Lee, C. Bolger, P. Kelleher, M. McDonald, P. J. Byrne, T. Gorey, T. P. Hennessy, E. B. Casey, M. MacMahon, B. Hogan, M. O’Sullivan, M. G. Courtney, J. S. Doyle, D. Hamilton, T. Dinan, Fiona M. Stevens, D. Nugent, P. F. Fottrell, J. L. Templeton, M. Madden, M. Elliot, A. Ah Kion, L. N. Yatham, S. Barry, T. Boyle, D. J. Veale, O. Fitzgerald, G. S. A. McDonald, S. R. McCann, D. G. Weir, H. Saleh, and D. Waldron

Subjects
City hospital, Irish, business.industry, language, Medicine, Library science, Optometry, General Medicine, business, language.human_language
Published
1990
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10. Helicobacter pylori, hypergastrinaemia, and recurrent abdominal pain in children

Author

A. G. Bailie, J. E. S. Ardill, W. A. McCallion, K. B. Bamford, V.E. Boston, and S R Potts

Subjects
Male, medicine.medical_specialty, Abdominal pain, Cross-sectional study, Enzyme-Linked Immunosorbent Assay, Gastroenterology, Immunoglobulin G, Helicobacter Infections, Recurrence, Seroepidemiologic Studies, Internal medicine, Gastrins, Prevalence, Humans, Medicine, Child, Gastrin, Helicobacter pylori, biology, business.industry, Case-control study, General Medicine, biology.organism_classification, Recurrent abdominal pain, Abdominal Pain, Cross-Sectional Studies, Case-Control Studies, Gastritis, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, Female, Surgery, medicine.symptom, business
Abstract

The association between Helicobacter pylori and recurrent abdominal pain (RAP) is controversial. In this cross-sectional study, the authors aim to determine whether hypergastrinaemia causes RAP in children with H pylori gastritis. In 439 children age 4 to 13 years (mean 7.3 years) attending for nongastrointestinal day-case surgery, anti-Helicobacter immunoglobulin G (IgG) was identified in serum by an enzyme-linked immunosorbent assay (ELISA) method validated in children and fasting plasma gastrin was measured. A history of RAP was sought. One hundred twenty-seven children (29%) tested seropositive for H pylori. Fifty-one seronegative children (16.3%) and 22 seropositive children (17.3%) gave a history of RAP. The mean fasting gastrin in seronegative children was 52 ng/L compared with 117 ng/L in seropositive children (P < .001). The mean fasting gastrin in seropositive children with RAP (124 ng/L) was not significantly different from that of seropositive children without RAP (115 ng/L). The high prevalence of H pylori seropositivity in this study is at variance with other reported paediatric data from the developed world. No association between childhood H pylori gastritis, hypergastrinaemia, and RAP was found. In children with H pylori gastritis, the increase in circulating gastrin (mean 140% increase) is greater than that seen in adults (50% increase).

Published
1995
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11. Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection

Author

J. Bickley, V. E. Boston, S. R. Potts, Brian T. Johnston, James M. Sloan, John S. A. Collins, K. B. Bamford, and R. J. Owen

Subjects
Adult, DNA, Bacterial, Male, Adolescent, Spirillaceae, HindIII, Helicobacter Infections, Microbiology, Ribotyping, 23S ribosomal RNA, Humans, Family, Typing, Child, Cross Infection, Helicobacter pylori, biology, Gastroenterology, biology.organism_classification, DNA Fingerprinting, Restriction enzyme, DNA profiling, biology.protein, Female, Research Article
Abstract

Although a high prevalence of antibodies to Helicobacter pylori has been documented within families, culture and DNA typing of strains from infected children and their parents has not been evaluated. This study aimed to analyse H pylori infection within family groups. Endoscopy, gastric biopsy, and H pylori culture were performed on all eight parents of four children who presented with dyspepsia and who had a positive H pylori culture. All biopsy specimens were cultured on Columbia based blood agar under microaerophilic conditions for four days. The DNA from each strain was extracted and electrophoretic patterns were compared after digestion with restriction endonucleases Hae III or Hind III. Ribotyping using a biotinylated cDNA probe prepared from 16S and 23S rRNA of H pylori NCTC 11638 was also used. Seven of the parents were positive for H pylori on urease testing, histology, and on culture. DNA typing showed the same or a similar strain to be present in at least two family members in three of the four family groups. In family 1, the mother, father, and child all had an identical strain; in family 2, father and son had a similar related strain; father and mother had the same strain in family 3; and all strains were unique in family 4. These data provide evidence for either intrafamilial cross infection or a common source of infection within family groups.

Published
1993
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12. A prospective randomised trial of a 'test and treat' policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic

Author

T. C. K. Tham, K. B. Bamford, R. G. P. Watson, John S. A. Collins, R. J. McFarland, and A. Heaney

Subjects
Adult, Male, medicine.medical_specialty, Urea breath test, macromolecular substances, Gastroenterology, Article, Helicobacter Infections, Quality of life, Ambulatory care, Internal medicine, Ambulatory Care, medicine, Humans, Endoscopy, Digestive System, Prospective Studies, Young adult, Dyspepsia, Prospective cohort study, Referral and Consultation, Intention-to-treat analysis, medicine.diagnostic_test, biology, Helicobacter pylori, business.industry, biology.organism_classification, Clinical trial, Treatment Outcome, Quality of Life, Commentary, Female, business
Abstract

BACKGROUNDManagement of dyspepsia remains a controversial area. Although the EuropeanHelicobacter pylori study group has advised empirical eradication therapy without oesophagogastroduodenoscopy (OGD) in young H pylori positive dyspeptic patients who do not exhibit alarm symptoms, this strategy has not been subjected to clinical trial.AIMSTo compare a “test and treat” eradication policy against management by OGD.PATIENTSConsecutive subjects were prospectively recruited from open access OGD and outpatient referrals.METHODSH pylori status was assessed using the carbon-13 urea breath test.H pylori positive patients were randomised to either empirical eradication or OGD. Symptoms and quality of life scores were assessed at baseline and subsequent reviews over a 12 month period.RESULTSA total of 104H pylori positive patients aged under 45 years were recruited. Fifty two were randomised to receive empirical eradication therapy and 52 to OGD. Results were analysed using an intention to treat policy. Dyspepsia scores significantly improved in both groups over 12 months compared with baseline; however, dyspepsia scores were significantly better in the empirical eradication group. Quality of life showed significant improvements in both groups at 12 months; however, physical role functioning was significantly improved in the empirical eradication group. Fourteen (27%) in the empirical eradication group subsequently proceeded to OGD because of no improvement in dyspepsia.CONCLUSIONSThis randomised study strongly supports the use of empirical H pylori eradication in patients referred to secondary practice; it is estimated that 73% of OGDs in this group would have been avoided with no detriment to clinical outcome.

Published
1999

13. Regulation of the mucosal immune response

Author

K. B. Bamford, Gang Ye, Victor E. Reyes, Gary R. Klimpel, Fei Song, Peter B. Ernst, Helene A. Haeberle, and Sheila E. Crowe

Subjects
Inflammation, Antigen Presentation, Mucosal Immune Responses, animal diseases, Immune regulation, chemical and pharmacologic phenomena, T-Lymphocytes, Helper-Inducer, biochemical phenomena, metabolism, and nutrition, Biology, T-Lymphocytes, Regulatory, Infectious Diseases, Immune system, Virology, Immunology, medicine, bacteria, Animals, Humans, Parasitology, medicine.symptom, Mucosal immunity, Immunity, Mucosal
Abstract

Infectious diseases continue to exact an extensive toll on populations living closest to the equatorial regions of the globe. A substantial proportion of these infections gain access to the host via the mucosal tissues. Thus, the development of new vaccines that enhance mucosal immunity is considered to be of paramount importance in order to prevent or limit the impact of these infections. Mucosal immune responses must discriminate between commensal flora within the lumen and potential pathogens. These responses are highly adapted to induce protection without excessive amounts of inflammation. The balances that regulate mucosal immune and inflammatory responses have to be understood if effective mucosal immunity is to be induced through local immunization. This review will summarize some of the unique properties of mucosal immune responses and focus on recent advances that have significantly influenced our understanding of the regulation of immune and inflammatory responses following infection.

Published
1999

14. Rapid serological diagnosis of Helicobacter pylori: a need for caution and re-evaluation

Author

K. B. Bamford, A. Heaney, J. S. A. Collins, R. J. McFarland, and R. G. P. Watson

Subjects
Adult, Male, medicine.medical_specialty, Screening test, Adolescent, Gastroenterology, Sensitivity and Specificity, Serology, Helicobacter Infections, Local evaluation, Internal medicine, Gastroscopy, medicine, Humans, Serologic Tests, Dyspepsia, biology, Helicobacter pylori, business.industry, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Peptic ulcer, Female, business
Abstract

Screening for Helicobacter pylori in dyspeptic patients may improve selectivity for gastroscopy. Rapid serological tests based on ELISA technique are cheap, readily available and simple to use in the clinical setting. However local evaluation is essential in order to validate these techniques. Fifty-six dyspeptic patients (aged less than 45 yr) had a rapid serological test (Helisal) performed prior to gastroscopy. At gastroscopy H. pylori status was assessed using culture and histology. The Helisal sensitivity was 80 per cent, specificity 82 per cent. Screening patients with the Helisal test would have missed 6 patients with peptic ulcer disease and 2 with oesophagitis. The Helisal test did not perform satisfactorily as a screening test in selection of patients for gastroscopy.

Published
1998

15. Community-acquired lower respiratory tract infection: implementation of an antibiotic protocol

Author

I B, Menown, J A, Archbold, K B, Bamford, P M, Bell, and M E, Callender

Subjects
Community-Acquired Infections, Lung Diseases, Clinical Protocols, Humans, Bacterial Infections, Prospective Studies, Anti-Bacterial Agents
Abstract

Enthusiastic formulation of clinical guidelines continues to increase but although theoretical difficulties in guideline implementation have been recognised, little attention has been paid to their effectiveness in everyday clinical practice. The introduction of a protocol for empirical treatment of lower respiratory tract infection (PETRI) to an acute medical take-in unit in Belfast is described. Early involvement of all relevant staff, preparation of user-friendly flow charts, and imaginative publicity, resulted in an initial implementation rate of 75%. The role of implementation as a significant rate-limiting step in the audit cycle is emphasised.

Published
1997

16. Randomised controlled trial of ranitidine versus omeprazole in combination with antibiotics for eradication of Helicobacter pylori

Author

T C, Tham, J S, Collins, C, Molloy, J M, Sloan, K B, Bamford, and R G, Watson

Subjects
Adult, Aged, 80 and over, Male, Peptic Ulcer, Adolescent, Helicobacter pylori, Drug Resistance, Microbial, Middle Aged, Anti-Ulcer Agents, Ranitidine, Anti-Bacterial Agents, Helicobacter Infections, Humans, Drug Therapy, Combination, Female, Single-Blind Method, Omeprazole, Aged, Research Article
Abstract

This study compared high dose ranitidine versus low dose omeprazole with antibiotics for the eradication of H pylori. 80 patients (mean age 48 years, range 18-75) who had H pylori infection were randomised in an investigator-blind manner to either a two-week regime of omeprazole 20 mg daily, amoxycillin 500 mg tid and metronidazole 400 mg tid (OAM), or ranitidine 600 mg bd, amoxycillin 500 mg tid and metronidazole 400 mg tid (RAM), or omeprazole 20 mg daily and clarithromycin 500 mg tid (OC), or omeprazole 20 mg daily and placebo (OP). H pylori was eradicated in 6 of 19 patients in the OAM group (32%); 8 of 18 in the RAM group (44%), 4 of 15 in the OC group (27%); none of 18 in the OP group (0%). [< P0.005 for OAM, RAM, OC vs OP; P = N.S. between OAM, RAM, OC]. Overall metronidazole resistance was unexpectedly high at 58%. Eradication rates in metronidazole sensitive patients were 71% (5/7) and 100% (3/3) for OAM and RAM respectively. In conclusion, H pylori eradication rates using high dose ranitidine plus amoxycillin and metronidazole may be similar to that of low dose omeprazole in combination with the same antibiotics for omeprazole with clarithromycin. Overall eradication rates were low due to a high incidence of metronidazole resistance but were higher in metronidazole-sensitive patients. Even high dose ranitidine with two antibiotics achieves a relatively low eradication rate. These metronidazole-based regimens cannot be recommended in areas with a high incidence of metronidazole resistance.

Published
1996

17. Helicobacter pylori infection in children: relation with current household living conditions

Author

A. M. Dalzell, W. A. McCallion, A. G. Bailie, L. J. Murray, K. B. Bamford, and Dermot O'Reilly

Subjects
medicine.medical_specialty, Adolescent, Enzyme-Linked Immunosorbent Assay, Northern Ireland, Helicobacter Infections, Risk Factors, Epidemiology, medicine, Odds Ratio, Humans, Risk factor, Child, biology, Helicobacter pylori, business.industry, Public health, Gastroenterology, Overcrowding, Odds ratio, biology.organism_classification, Crowding, El Niño, Social Class, Socioeconomic Factors, Child, Preschool, Immunology, Housing, business, Breast feeding, Demography, Research Article
Abstract

BACKGROUND: Studies demonstrating that deprived household living conditions during childhood are risk factors for acquisition of Helicobacter pylori infection have been performed mainly in adults, who probably acquired the infection several decades ago. This study investigates whether deprived household living conditions remain important risk factors for infection in subjects (children) with recently acquired infection. AIMS: To examine the relation between current household living conditions and acquisition of H pylori infection in childhood. SUBJECTS/SETTING: Opportunistically recruited group of 367 children, aged 3 to 15 years, undergoing routine non-gastrointestinal day surgery. METHODS: Anti-H pylori IgG antibodies measured by a commercial enzyme linked immunosorbent assay validated for use in children. Postal questionnaire collecting sociodemographic data and data on household living conditions. RESULTS: Infection was associated with social class and overcrowding in the household. After adjustment for age, social class, and household density, a positive association remained between infection with H pylori and bed-sharing between children and parents on one or two nights per week, odds ratio for infection (95% CI), 2.29 (1.21, 4.32) or more frequently, odds ratio for infection (95% CI), 2.95 (1.35, 6.45). CONCLUSIONS: The continuing importance of household living conditions in the acquisition of H pylori infection is confirmed and household crowding and sharing a bed with a parent are identified as risk factors for infection.

Published
1996

18. Is the Th1/Th2 lymphocyte balance upset by Helicobacter pylori infection?

Author

W. R. Gourley, V. E. Reyes, K. B. Bamford, Peter B. Ernst, and H. Häberle

Subjects
business.industry, medicine.drug_class, Lymphocyte, Incidence (epidemiology), Antibiotics, Inflammation, Disease, medicine.anatomical_structure, Immunity, Immunology, Gastric mucosa, Medicine, medicine.symptom, business, Pathogen
Abstract

Since H. pylori became recognized as a gastric pathogen, many people have felt that antibiotics would expedite the eradication of, or at least the decrease in, gastric diseases associated with this infection. However, history reminds us that antibiotics have been relatively ineffective at eradicating other bacterial infections. In the case of H. pylori the infection is widespread on a global basis. Although the rate of infection with H. pylori is slow, our understanding of the epidemiology of the spread of this pathogen is incomplete, thereby limiting the success of interventions to decrease the incidence of infection. Furthermore, antibiotic regimens may be too expensive for some individuals or societies, and resistance to antibiotics is emerging. Thus, it is essential to understand the immuno-pathogenesis of gastric disease associated with H. pylori infection and to counter these processes through vaccines that may shift the host response away from chronic inflammation and tissue destruction towards effective immunity. This review will summarize the means by which mucosal immune responses can confer protection to luminal flora without inducing disease. In addition, the current understanding of T-cell biology in H. pylori infection will be examined and contrasted with the T-cell responses that may be induced by the vaccines for H. pylori that are currently in the development stage.

Published
1996
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19. Age dependent hypergastrinaemia in children with Helicobacter pylori gastritis--evidence of early acquisition of infection

Author

S. R. Potts, J. E. S. Ardill, V. E. Boston, W. A. McCallion, and K. B. Bamford

Subjects
medicine.medical_specialty, Adolescent, Spirillaceae, Enzyme-Linked Immunosorbent Assay, Achlorhydria, Gastroenterology, Helicobacter Infections, Internal medicine, Gastrins, medicine, Humans, Child, Gastrin, biology, Helicobacter pylori, business.industry, digestive, oral, and skin physiology, Age Factors, biology.organism_classification, medicine.disease, Gastrointestinal disorder, El Niño, Socioeconomic Factors, Child, Preschool, Gastritis, biology.protein, medicine.symptom, Antibody, business, hormones, hormone substitutes, and hormone antagonists, Research Article
Abstract

Acute Helicobacter pylori associated gastritis causes achlorhydria, a powerful stimulus to gastrin secretion. If H pylori infection is acquired primarily in early childhood, then the degree of hypergastrinaemia in seropositive children should be age dependent. Anti-Helicobacter antibodies and fasting gastrin concentrations were measured in 439 children aged 4 to 13 years attending hospital for routine day case surgery not connected with any gastrointestinal disorder. Thirty per cent were seropositive for H pylori. There was an inverse relationship between the fasting gastrin concentration and age; the mean fasting gastrin in children aged 4-5 years, 155 ng/l, was significantly higher than that seen in children aged 12-13 years, 90 ng/l. The more noticeable hypergastrinaemia seen in young children with H pylori associated gastritis may reflect achlorhydria associated with acute H pylori infection and suggests that this is primarily acquired in early childhood.

Published
1995

20. Low incidence of campylobacter enteritis in Northern Ireland

Author

K. B. Bamford and A. C. Lafong

Subjects
Diarrhea, Veterinary medicine, medicine.medical_specialty, Immunology, Northern Ireland, Northern ireland, Campylobacter jejuni, Enteritis, Feces, Campylobacter fetus, Epidemiology, Campylobacter Infections, medicine, Humans, Prospective Studies, biology, business.industry, Incidence (epidemiology), Public Health, Environmental and Occupational Health, medicine.disease, biology.organism_classification, humanities, medicine.symptom, business, Demography, Research Article
Abstract

SUMMARYIn a prospective survey carried out over 9 months in 1984 in the Department of Bacteriology, Belfast City Hospital, Campylobacter jejuni was isolated from 24 out of 1200 faecal specimens (2%) from patients with acute diarrhoea. This isolation rate is much lower than that from other parts of mainland Britain which report an isolation rate of between 8 and 15%. It is difficult to explain this large discrepancy but the limited availability of unpasteurized milk and the generally worse summer here (fewer barbecues, picnics) may be some reasons to explain this low incidence in N. Ireland.

Published
1986

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