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The long-term development of the mining industry in the Komsomolsky, Kavalerovsky and Dalnegorsky districts of the Far East of Russia caused origination of large-scale mining technogenic systems. During the period of socalled “perestroika”, mining production in the region was suspended, while mine workings (pits, adits) and tailings dumps were not subjected to any kind of preservation or reclamation. Only the boron and lead-zinc mining sectors in the Dalnegorsk district are currently in operation. The purpose of this paper is to assess the composition of mine waters, reveal the conditions of their formation, the presence of various aqueous species (coordination compounds and ions) of different elements and establish the parameters of precipitation of a number of hypergenic natural and technogenic minerals from these waters. This paper provides the hydrochemical characteristics of mine waters in the mining technogenic systems of tin-sulfide, copper-tin, tin-polymetallic, and polymetallic deposits, indicates the conditions of their formation and describes the adverse impact on the hydrosphere, as well as on human health in these districts. The studies of sulfide oxidation and mine water formation processes were carried out by the method of physicochemical simulation involving the use of the Selektor software package. The Eh–pH parameters of solutions, their composition with respect to stable aqueous species (complex compounds and simple ions), paragenetic associations (paragenesis) of precipitating hypergenic minerals with respect to the primary composition of ores and host rocks were established in a wide temperature range (from −25 to +45 °С). It has been established that the simulated micropore solutions participating in the formation of mine waters exhibit a wide range of Eh–pH parameters: Eh from 0.55 to 1.24 V and pH from 0.3 to 13.8. The technogenic minerals Fe, Cu, Zn, Pb and Sb belonging to oxide and hydroxide, sulphate, and arsenate classes are precipitated from them. Mine waters of high concentration, prior to and after the precipitation of technogenic minerals (weight of which reaches the hundreds of grams), are released into the hydrosphere. The simulated solutions contain all the elements of sulfide ores: Cu, Zn, Pb, Fe, Ag, As, Sb and S, whereas their concentrations in the form of aqueous species reach the tens of grams, while under cryogenic conditions the concentrations are by one or two orders of magnitude higher as a result of ice formation. The forms of migration of the elements depend on the temperature conditions. The negative impact of mine waters on the region hydrosphere and human health was demonstrated. In the districts under consideration, obvious trend of increasing morbidity (for almost all types of diseases) by 2 times both in adults and in children as compared to other Far Eastern regions was revealed. In addition, the morbidity of the child population for almost all the diseases under consideration proved much higher than in adults.

Introduction. The article analyzes the structure of the epistemology of knowledge of weak artificial intelligence in comparison with the structure of human knowledge. The article was written within the framework of one of the most demanded branch sections of philosophy – the philosophy of artificial intelligence. The novelty of the research is based on the idea of applying the analysis of knowledge developed within the framework of analytical epistemology to the field of artificial intelligence.Methodology and sources. The article is written in the framework of analytical tradition in philosophy. We use conceptual analysis to analyze the most crucial aspects of knowledge. This method assumes that in order to explain a complex phenomenon, it is necessary to analyze its components. This method formed the basis of an analytical discussion about knowledge in the second half of the 20th century. The article also uses comparative analysis.Results and discussion. People's knowledge is characterized by three essential characteristics – the presence of information-bearing mental states, their reliability, and factuality. We analyzed to what extent the information-carrying internal states of a weak AI correspond to these qualities. The authors concluded that internal states can be considered beliefs if they are weakly interpreted, they can have a high degree of reliability under certain conditions, and they can have factuality if we accept that a weak AI has beliefs.Conclusion. A weak interpretation of the concept of belief allows us to argue that neural networks are capable of having beliefs. A more rigorous interpretation of the concept of belief also includes the requirement to understand the meaning. However, we do not have at our disposal a satisfactory theory of understanding meaning. In this case, the condition of reliability is the only criterion of knowledge to which the functional states of machines can correspond in the case of certain tasks, in connection with which the problem of generality arises especially acutely.

Introduction. Empirical studies of recent years convincingly show that the character of sensory perception can be influenced by non-cognitive mental states of the agent, such as her desires. The aim of the paper is to analyze how this causal connection between agent's wishes and her sensations can affect the epistemological status of dependent sensations.Methodology and sources. The author examines S. Siegel's argument on this issue. S. Siegel argues that the empirically proven dependence of sensations on desires (wishful seeing) should lead to a decrease of the epistemological status of sensations to the same extent as the dependence of beliefs on desires (wishful thinking) leads to a decrease of the epistemological status of these beliefs. Thus Siegel's argument concludes that the phenomenon of wishful seeing deprives us of any reason to accept sensations as credible evidence of the states of the world. So, this is an argument in favor of skepticism.Results and discussion. The article discusses two main strategies for rejecting Siegel's argument. According to the first strategy proposed by R. Long, sensations are not so similar to beliefs that one can conclude that their epistemological status should be decreased on the basis of their dependence on desires. According to another strategy for refuting Siegel's argument, proposed by A. Raftopoulos, the influence of desires on perception does not extend to early vision. Early vision is free from the influence of higher order conscious mental states. The dependence of the results of sensory perception on other mental states is reduced to the influence of these states on the agent's attention. At the same time, attention can be volitionally controlled and can be trained. Therefore dependent perception under certain conditions can be rationally accepted.Conclusion. Thus, the article shows that, even though perception is dependent on other non-cognitive mental states, such as desires, this dependence does not necessarily lead to a decrease in the epistemological status of sensations, so sensations can be rationally accepted under certain conditions. This means that Siegel's argument for skepticism is not compelling.

A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pain test. Some the tested compounds showed an antinociceptive effect, superior to that of the reference drug (metamizole sodium).

Condensation of benzaldehyde with malononitrile and malononitrile dimer (2-aminopropene-1,1,3-tricarbonitrile) in the presence of an excess of morpholine in ethanol afforded the morpholinium salt of 6-amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile. The latter, under the Mannich reaction conditions with the participation of primary amines and formaldehyde, gives 6-amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile, 2-(dicyanomethylene)-6-(hydroxymethylamino)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile or zwitterionic aminomethylation products, 6-(ammoniomethylamino)-3,5-dicyano-4-phenylpyridin-2-yl)dicyanomethanides. Structure of the obtained compounds was established using 2D NMR spectroscopy and single crystal X-ray diffraction analysis. In silico predictive analysis of the biological activity of new compounds was carried out.

Sequential reaction of cyclohexanone with malononitrile and 2-aminopropene-1,1,3-tricarbonitrile in the presence of potassium hydroxide or sodium ethylate in ethanol gave 4-imino-2-(dicyanomethylene)-3-azaspiro[5.5]undecane-1,5-dicarbonitrile. The latter reacted with primary amines and an excess of formaldehyde to form new 2-(dicyanomethylene)-3,7-diazaspiro[bicyclo[3.3.1]non-3-ene-9,1′-cyclohexane]-1.5-dicarbonitrile derivatives. Contrary to the literature data, the reaction of cyclohexanone with 2-aminopropene-1,1,3-tricarbonitrile in benzene in the presence of piperidine and glacial acetic acid led to the formation of 2,4-diamino-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitrile.

The reaction of (2E,4E)-5-phenyl-2-cyano-2,4-pentadienethioamide or (E)-3-(2-nitrophenyl)acrolein and cyanothioacetamide with α-bromoketones afforded new (2E,4E)-5-aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitriles. Direct bromination of the latter by the action of bromine in DMF proceeded regiospecifically at the C5 position of the thiazole ring without affecting the diene system and leads to the formation of new series of (2E,4E)-5-aryl-2-(5-bromo-4-arylthiazol-2-yl)penta-2,4-dienenitriles.

The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics.

Nowadays the search of new high-efficiency and safe drugs for the pharmacotherapy of diseases accompanied by pain syndrome is an active area of modern pharmacological research. 170 new derivatives of di- and tetrahydropyridines synthesized on the basis of the Chemex Research Laboratory, Vladimir Dahl Lugansk State University were exposed to the virtual bioscreening using the Swiss Target Prediction software. The paper describes screening studies in vivo of 5 samples of sulfur-containing di- and tetrahydropyridines (laboratory codes d02-138, as-262, f02-079, cv-074, cv-143) in the standard hot plate test in comparison with the reference drug — metamizole sodium. The compounds in the dose of 5 mg/kg were given intragastrically 1 hour and a half before placing the rats on the hot plate, the reference drug in the dose of 7 mg/kg also was given intragastrically 1 hour and a half before placing the rats on the hot plate. The compounds with laboratory codes as-262 (allyl 6-({2-[(4-acetylphenyl)amino]-2-oxoethyl}thio)-5-cyano-4-(2-furyl)-2-methyl-1,4-dihydropyridine-3-carboxylate) and d02-138 (ethyl 4-[({[3-cyano-5-{[(2,4-dichlorophenyl)amino]carbonyl}-4-(2-furyl)-6-methyl-1,4-dihydropyridinе-2-yl]thio}acetyl)amino]benzoate) possess the most pronounced analgesic activity in the dose of 5 mg/kg, they demonstrated 2.03 and 1.9-fold efficiency in comparison to metamizole sodium respectively. The rest three specimens demonstrated metamizole sodium-like analgesic activity.

1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5-a]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried out.

Nanowires have been formed from FeNi and FeCo alloys by the template synthesis method based on galvanic filling of pores of track membranes. A change in the nanowire elemental composition with a change in the electrolyte composition and with a change in the deposition potential has been studied. FeNi nanowires exhibit the effect of anomalous Fe codeposition: the iron content in the nanowires is much higher than that in the electrolyte. The difference increases with an increase in the initial concentration and with a decrease in the growth potential. It has also been found that the iron concentration increases in nanowire vertices. For FeCo nanowires, their composition corresponds to the electrolyte composition and changes only slightly with a change in the potential. An analysis of the X-ray diffraction data has determined the character of change in the spectra under varying growth conditions. The X-ray spectra of FeNi are found to depend on the growth potential (the intensity of phase peaks changes). Mossbauer measurements have revealed spontaneous magnetization for all samples of arrays of nanowires along their axes. The dependence of hyperfine magnetic field strength Bhf at 57Fe nuclei on the composition of nanowires of FexCo1 – x and FexNi1 – x solid solutions is obtained for the first time. It is found that the Bhf value decreases with an increase in the electrodeposition rate (or with an increase in deposition potential U).

In present medical practice adaptogens and antihypoxants are a promising, but still insufficiently studied group of medicines. The largest evidence base among plant adaptogens was developed for ginseng, aralia, eleutherococcus, lemongrass, rhodiola, leuzea, sterculia. Antihypoxants, like trimetazidine, meldonium, succinic and -aminobutyric acid medications are included in the clinical guidelines. They have the most pronounced antihypoxic effects in a variety of diseases and pathological conditions, accompanied by impaired energy metabolism in the tissues. But their effect is not always high due to the variety of etiological factors causing hypoxia. Tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives characterized by various pharmacodynamic effects with low toxicity which opens up prospects for a detailed further study. In animal experiments, the most pronounced adaptogenic and antidepressant effects is exerted by compounds TD-0348 and TD-0479, superior in strength to the antihypoxants used in modern clinical practice, the classic plant adaptogen ginseng.

Thorium dioxide represents a future of the world market of nuclear fuel for fourth generation nuclear reactors. In this regard, the problems of technologies for thorium separation from irradiated fuel, its conversion into fuel raw materials, and fabrication of required quality fuel products need effective solutions. In this work the synthesis of microcrystalline mesoporous ThO2 powders through the deposition of the oxalate complex from nitrate solutions, and its consolidation by spark plasma sintering (SPS) technology has been studied. The influence of the SPS temperature ranging within 1000–1600°С on the ThO2 powder shrinkage dynamics, phase composition, microstructure, and density of pelletized ceramic products has been studied. Vickers microhardness parameters of samples have been determined. The results show that high-speed (minutes-taking) SPS consolidation of powders at 1600°C and 80 MPa can provide ThO2 ceramics with 92.5% theoretical density. Microcrystalline powders with particle sizes averaging 3-4 µm can be used as raw materials instead of less accessible nanoscale materials. The study shows the expediency and prospects of further studies with the view of SPS technology adaptation for the needs of the nuclear industry.

An accurate single-crystal X-ray diffraction study of bismuth-containing HoFe3(BO3)4between 11 and 500 K has revealed structural phase transition atTstr= 365 K. The Bi atoms enter the composition from Bi2Mo3O12-based flux during crystal growth and significantly affectTstr. The content of Bi was estimated by two independent methods, establishing the composition as (Ho0.96Bi0.04)Fe3(BO3)4. In the low-temperature (LT) phase belowTstrthe (Ho0.96Bi0.04)Fe3(BO3)4crystal symmetry is trigonal, of space groupP3121, whereas at high temperature (HT) above 365 K the symmetry increases to space groupR32. There is a sharp jump of oxygen O1 (LT) and O2 (LT) atomic displacement parameters (ADP) atTstr. O1 and O2 ADP ellipsoids are the most elongated over 90–500 K. In space groupR32 specific distances decrease steadily or do not change with decreasing temperature. In space groupP3121 the distortion of the polyhedra Ho(Bi)O6, Fe1O6and Fe2O6, B2O3and B3O3increases with decreasing temperature, whereas the triangles B1O3remain almost equilateral. All BO3triangles deviate from theabplane with decreasing temperature. Fe–Fe distances in Fe1 chains decrease, while distances in Fe2 chains increase with decreasing temperature. The Mössbauer study confirms that the FeO6octahedra undergo complex dynamic distortions. However, all observed distortions are rather small, and the general change in symmetry during the structural phase transition has very little influence on the local environment of iron in oxygen octahedra. The Mössbauer spectra do not distinguish two structurally different Fe1 and Fe2 positions in the LT phase. The characteristic temperatures of cation thermal vibrations were calculated using X-ray diffraction and Mössbauer data.

Introduction. In the modern world people are exposed to the influence of adverse psychological and physical factors, escalating in intensity. The search for new pharmacodynamic effects of [1,3,5]-thiadiazine derivatives designated by significant biological activity of these compounds is an essential issue.Aim. To research adaptogenic activity of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives using a modified Porsolt Forced Swim Test.Materials and methods. Four substances from the group of 3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6Hpyrido[2,1-b][1,3,5]thiadiazine-9-carbonitriles were selected for the research. Rats were divided into a control group, 5 reference groups (amitriptyline, caffeine, thiotriazolin, thiocetam, ginseng) and 4 experimental groups according to the number of the studied original tetrahydropyrido[2,1-b][1,3,5] thiadiazine derivatives.Results. Intragastric injection of substance 2 for 5 days in the modified forced swim test (forced swimming with freight) increased work capacity and endurance of the rats by 103.42% as opposed to the initial results. The detected adaptogenic activity of this tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivative six times exceeds adaptogenic activity of ginseng and seven times that of amitriptyline. The rats in the control group were active for a bit longer time. Ginseng raised the time of activity by 17% at day 5. Caffeine essentially reduced work capacity and endurance. Amitriptyline showed adaptogenic activity at day 3 of the research (increase by 10.4%). Thiotriazolin also showed adaptogenic activity on day 3 of the research (increase by 30.17%). Thiocetam increased the time of activity by 78.55%. Substance 4 had adaptogenic activity too; it increased the time of activity in aversive conditions by 58.25%, which three times exceeds this parameter for ginseng and four times for amitriptyline.

Mossbauer spectra of single crystals of sulfur-doped iron selenide FeSe0.91S0.09 are studied in a wide temperature range, including the vicinity of structural and superconducting transitions. It is found that iron atoms exhibit a nonmagnetic state even in the range of helium temperatures, which can be attributed to the low-spin state of Fe2+ (3d6, S = 0) ions. It is shown that this state remains nearly unchanged at temperatures close to the superconducting transition temperature. This means that the low-spin state of iron ions most probably results from some structural features and is not directly related to superconductivity. The temperature dependence of the parameters characterizing the hyperfine interaction exhibits several anomalies in the ranges of structural and electronic transitions. The Debye temperature ΘM = 478 K determined for the iron sublattice turns out to be much higher than the value ΘM = 285 K for the undoped FeSe1 - δ compound.

The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2-a][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N-, S,N-, and Se,N-containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic activities.

Актуальність. Анемічний синдром, який супроводжує розвиток патології у хворих з колоректальним раком, може стати причиною серйозних ранніх післяопераційних ускладнень. Є актуальним питання про те, як впливають заходи передопераційної підготовки на стан структур кишечника і клінічну ситуацію в цілому. Особливе значення в цій ситуації набуває корекція анемічного синдрому ще до проведення оперативного втручання за допомогою стимуляторів гемопоезу. Мета дослідження – аналіз динаміки еритропоезу і змін тканинної і клітинної ультраструктури в інтраопераційних біоптатах товстої кишки після стимуляції еритропоезу в передопераційній підготовці при хірургічному лікуванні хворих з колоректальним раком. Методи . Проведено вивчення червоного кісткового мозку і стінки товстого кишечника за допомогою трансмісійної електронної мікроскопії. Результати . Для більшості хворих з колоректальним раком характерний розвиток ознак неефективного еритропоезу з помірним уповільненням диференціювання еритробластів і затримкою виходу зрілих еритроцитів у системну циркуляцію. Стимуляція еритропоезу за допомогою епоетину призводить до підвищення функціональної активності центральних макрофагів еритропоетичних острівців червоного кісткового мозку і посилення їх міжклітинної асоціації з дозріваючими еритроїдними клітинами. Це супроводжується формуванням великої кількості повноцінних еритроцитів, збільшенням чисельної щільності клітин еритроїдного ряду і нормалізацією їх ультраструктури. Підсумок. Стимуляція еритропоезу за допомогою епоетину в передопераційному періоді обумовлює стримування ендотеліальної дисфункції за рахунок обмеження дистрофічних і деструктивних змін органел ендотеліальних клітин, стабілізації їх мембран, запобігання спазму артеріол, явищ стазу і сладжа еритроцитів. Як наслідок, явища інфільтрації, периваскулярного й інтерстиційного набряку в складі оболонок кишкової стінки виражені набагато меншою мірою, ніж у групі хворих без передопераційної активації еритропоезу.

The paper presents the analysis of the structure and electromagnetic properties of magnetodielectric composite material polymerized under the influence of the external magnetic field. The structure, phase composition and magnetic properties are determined for Z-type barium ferrite employed as a filling material in the production of test specimens. It is shown that the external magnetic field has an effect on the structure of this composite material. The proposed treatment technique allows fabricating test specimens with both magnetic and dielectric anisotropy parameters.

The paper considers an approach to monitoring the condition of the treated surface in real time based on the laser-induced breakdown spectroscopy technique. As a result of the study, the aluminum alloy was cleaned from the plimer coating, spectral analysis was carried out, the relationship between the processing modes and the thickness of the coating being removed was experimentally established, which allows removing the paint coating in one pass without damaging the underlying layers. The optimal spectral range for the control operation, the contrasting spectral lines of the elements that make up the coating, the optimal parameters of laser exposure are determined based on the monitoring data of the spectral signal recorded during laser processing

A method of strengthening reinforced concrete structures by external reinforcement systems based on carbon fiber is widely used. Significant experience is accumulated in industrial and civil construction; there is also a certain experience of strengthening reinforced concrete structures of hydraulic structures. It was necessary to conduct experimental studies to justify technical solutions for strengthening the reinforced concrete structures of hydraulic structures. A characteristic feature of reinforced concrete structures of hydraulic structures is the mandatory availability of inter-block construction joints, which are caused by the need to build massive hydraulic structures with tiers and blocks with interruptions in concreting. Previously studies of reinforced concrete structures strengthened by composite materials were conducted without taking into account the block structure. The results of experimental studies of reinforced concrete beam structures of hydraulic structures reinforced with carbon strips having horizontal and vertical inter-block building seams are presented in the article. Experimental studies of a series of reinforced concrete beam-type models made of concrete of class B15 with longitudinal reinforcement from two bars. Their diameter is 10 mm and class is A500C (percentage of reinforcement 0.39%). The used concrete class is B25 with longitudinal reinforcement of three bars of diameter 12 mm and class A500C (percentage of reinforcement 0.84%). Their inter-block construction joints is before their strengthening and after reinforcement by longitudinal and transverse carbon composite tapes. In this case, a special type of cracking was recorded, in which cracks propagate along vertical and horizontal inter-block building seams. Due to the strengthening of reinforced concrete structures with carbon composite strips, the strength of the structures has increased, on average, by 1.78 times.

2,4-Dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile reacted with primary amines and formaldehyde on heating in boiling ethanol to give mixtures of 7-alkyl-2,4-dioxo-3,7-diazaspiro[bicyclo[3.3.1]nonane- 9,1′-cyclohexane]-1,5-dicarbonitriles and their ammonium salts. The former were isolated in 26–71% after acidification of the reaction mixture.

Aerobic reactions of iron(III), nickel(II), and manganese(II) chlorides with formaldoxime cyclotrimer (tfoH3) and 1,4,7-triazacyclononane (tacn) produce indefinitely stable complexes of general formula [M(tacn)(tfo)]Cl. Although the formation of formaldoxime complexes has been known since the end of 19th century and applied in spectrophotometric determination of d-metals (formaldoxime method), the structure of these coordination compounds remained elusive until now. According to the X-ray analysis, [M(tacn)(tfo)]+ cation has a distorted adamantane-like structure with the metal ion being coordinated by three oxygen atoms of deprotonated tfoH3 ligand. The metal has a formal +4 oxidation state, which is atypical for organic complexes of iron and nickel. Electronic structure of [M(tacn)(tfo)]+ cations was studied by XPS, NMR, cyclic (CV) and differential pulse (DPV) voltammetries, Mossbauer spectroscopy, and DFT calculations. Unusual stabilization of high-valent metal ion by tfo3- ligand was explained by the donation of electron density from the nitrogen atom to the antibonding orbital of the metal-oxygen bond via hyperconjugation as confirmed by the NBO analysis. All complexes [M(tacn)(tfo)]Cl exhibited high catalytic activity in the aerobic dehydrogenative dimerization of p-thiocresol under ambient conditions.

The article outlines the potential for the development of predictive systems for the drilling operations, as well as the main criteria that will determine technical requirements for research and development in these areas. Operational drilling efficiency improvements would include a whole range of options from developing solutions to decrease non-productive time (NPT) (e.g. by selecting optimum drilling parameters) to equipment performance analysis in order to predict equipment failures. The key areas where digital prediction systems could be implemented are the following: remote monitoring of drilling operations; predictive rig maintenance and repair system; predictive NPT recording and analysis system; geosteering, geomechanics, and petrophysics soft-ware; drilling failures prediction and prevention during drilling oil and gas wells; automated drilling system; and well-targeting technology system. The standalone software packages are to be combined into one automated and adaptive decision-making system based on physical and mathematical models of well construction and rock conditions. The presented study summarized a minimum number of models necessary for the operation of a predictive drilling system. The practical implementation of digital solutions in drilling is analyzed through the main approaches used in the development of predictive analytics algorithms. The basic assumptions for all algorithms are formulated to ensure the limitations of the developed model. Also, technical requirements are formulated for a uniform data collection and storage system that is the foundation of the predictive analytics block.

We report on the structural phase transitions in the S doped FeSe superconductor by powder synchrotron X ray diffraction at high pressures up to 18.5 GPa under compression and decompression modes. In order to create high quasi hydrostatic pressures, diamond anvil cells filled with helium as a pressure transmitting medium were used. It was found that at ambient pressure and room temperature, S doped FeSe has a tetragonal structure. Under compression, in the region of 10 GPa, a phase transition from the tetragonal into the orthorhombic structure is observed, which persists up to 18.5 GPa. Our results strongly suggest that, at decompression, as the applied pressure decreases to 6 GPa and then is completely removed, most of the sample recrystallizes into the hexagonal phase of the structural type NiAs. However, the other part of the sample remains in the high pressure orthorhombic phase, while the tetragonal phase is not restored. These observations illustrate a strong hysteresis of the structural properties of S doped FeSe during a phase transition under pressure., 13 pages, 10 figures

Since the advent of the first prototypes of power transformers with an amorphous core, of particular interest has been the prototyping and calculation of models of power transformers with the possibility of studying the influence of various factors on the properties of the finished product. However, an attempt to use HTSC windings in power transformers led not only to a significant improvement in the electrophysical properties of such transformers, but also to a significant complication of the modeling process of such a transformer, due to the appearance of additional external factors, such as a change in the electrical properties of the HTSC conductor depending on the nature of the load and operating modes of such a transformer. Based on this, the article highlights the methods of accounting for such effects during the construction of a mathematical model of a power transformer with HTSC windings.