90 results on '"K W Chu"'
Search Results
2. Implementing learning analytics in wiki-supported collaborative learning in secondary education: A framework-motivated empirical study.
- Author
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Xiao Hu 0001, Tzi-Dong Jeremy Ng, and Samuel K. W. Chu
- Published
- 2022
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3. Quality Assessment for Digital Stories by Young Authors.
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Joana K. Y. Tse, Stephanie W. Y. Chan, and Samuel K. W. Chu
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- 2021
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4. Relations among participation, fairness and performance in collaborative learning with Wiki-based analytics.
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Jeremy T. D. Ng, Xiao Hu 0001, Miyu Luo, and Sam K. W. Chu
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- 2019
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5. Re-examining students' reading experience in a gamified context from a self-determination perspective: A multiple-case study.
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Xinyu Chen, Xiuhan Li, Shum Yi Cameron Lee, and Samuel K. W. Chu
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- 2018
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6. Variation by lineage in serum antibody responses to influenza B virus infections.
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Yiu Chung Lau, Ranawaka A P M Perera, Vicky J Fang, Long Hei Luk, Daniel K W Chu, Peng Wu, Ian G Barr, J S Malik Peiris, and Benjamin J Cowling
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Medicine ,Science - Abstract
Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009-2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons.
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- 2020
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7. Needs assessment of ASIS&T publications: Bridging information research and practice.
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Rong Tang 0001, Lorri Mon, Jamshid Beheshti, Yuelin Li, Danielle Pollock, Chaoqun Ni, Samuel K. W. Chu, Lu Xiao 0002, Julia Caffrey, and Steven Gentry
- Published
- 2016
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8. Implementing learning analytics in wiki-supported collaborative learning in secondary education: A framework-motivated empirical study
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Xiao Hu, Jeremy T. D. Ng, and Samuel K. W. Chu
- Subjects
Human-Computer Interaction ,Education - Published
- 2022
9. Potentially avoidable mortality after endoscopic retrograde cholangiopancreatography in Australia: an 8‐year qualitative analysis
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Samantha Jolly, Matthew K. W. Chu, Aashray K. Gupta, Jessica Mitchell, Joshua G. Kovoor, Sasha K. Stewart, Wendy J. Babidge, Justin C. Y. Chan, Markus I. Trochsler, and Guy J. Maddern
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Surgery ,General Medicine - Published
- 2023
10. Relative incidence and individual-level severity of seasonal influenza A H3N2 compared with 2009 pandemic H1N1
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Kin On Kwok, Steven Riley, Ranawaka A. P. M. Perera, Vivian W. I. Wei, Peng Wu, Lan Wei, Daniel K. W. Chu, Ian G. Barr, J. S. Malik Peiris, and Benjamin J. Cowling
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Influenza ,Seroepidemiology ,Severity ,Cohort ,Severe outcomes ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Two subtypes of influenza A currently circulate in humans: seasonal H3N2 (sH3N2, emerged in 1968) and pandemic H1N1 (pH1N1, emerged in 2009). While the epidemiological characteristics of the initial wave of pH1N1 have been studied in detail, less is known about its infection dynamics during subsequent waves or its severity relative to sH3N2. Even prior to 2009, few data was available to estimate the risk of severe outcomes following infection with one circulating influenza strain relative to another. Methods We analyzed antibodies in quadruples of sera from individuals in Hong Kong collected between July 2009 and December 2011, a period that included three distinct influenza virus epidemics. We estimated infection incidence using these assay data and then estimated rates of severe outcomes per infection using population-wide clinical data. Results Cumulative incidence of infection was high among children in the first epidemic of pH1N1. There was a change towards the older age group in the age distribution of infections for pH1N1 from the first to the second epidemic, with the age distribution of the second epidemic of pH1N1 more similar to that of sH3N2. We found no serological evidence that individuals were infected in both waves of pH1N1. The risks of excess mortality conditional on infection were higher for sH3N2 than for pH1N1, with age-standardized risk ratios of 2.6 [95% CI: 1.8, 3.7] for all causes and 1.5 [95% CI: 1.0, 2.1] for respiratory causes throughout the study period. Conclusions Overall increase in clinical incidence of pH1N1 and higher rates of severity in older adults in post pandemic waves were in line with an age-shift in infection towards the older age groups. The absence of repeated infection is good evidence that waning immunity did not cause the second wave. Despite circulating in humans since 1968, sH3N2 is substantially more severe per infection than the pH1N1 strain. Infection-based estimates of individual-level severity have a role in assessing emerging strains; updating seasonal vaccine components; and optimizing of vaccination programs.
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- 2017
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11. More than Just Fun: A Sequential Explanatory Mixed Methods Study on 21st Century Skills Development in Esports
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Yuchun Zhong, Kai Guo, and Samuel K. W. Chu
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- 2023
12. Collaborative writing with wikis: an empirical investigation.
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Helen S. Du, Sam K. W. Chu, Randolph C. H. Chan, and Wei He 0018
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- 2016
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13. Experimenting with English Collaborative Writing on Google Sites.
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Nicole J. Tavares and Samuel K. W. Chu
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- 2012
14. New features in Wikiglass, a learning analytic tool for visualizing collaborative work on wikis.
- Author
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Xiao Hu 0001, Chengrui Yang, Chen Qiao, Xiaoyu Lu, and Sam K. W. Chu
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- 2017
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15. Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma—a cost-effectiveness analysis
- Author
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Tan To Cheung, Wing Chiu Dai, Chung Mau Lo, Ka Wing Ma, Wong Hoi She, Kenneth S. H. Chok, Kevin K. W. Chu, and Albert C. Y. Chan
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medicine.medical_specialty ,PET-CT ,Multivariate analysis ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Confidence interval ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Positron emission tomography ,030220 oncology & carcinogenesis ,Relative risk ,Hepatocellular carcinoma ,Medicine ,Original Article ,030211 gastroenterology & hepatology ,Radiology ,business - Abstract
Background: We aimed to identify predictive factors for positron emission tomography (PET)-detected hepatocellular carcinoma (HCC) metastasis and a cost-effective approach to preoperative PET-computed tomography (CT) for detecting metastasis. Methods: Clinicopathological and survival data of HCC patients having PET-CT with 18F-fludeoxyglucose (FDG) and 11C-acetate (ACT) following contrast-enhanced CT/magnetic resonance imaging (MRI) for preoperative tumor staging were reviewed. Binary logistic regression was performed to identify predictive factors for PET-detected metastasis. A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was studied. Results: Totally 152 patients were analyzed. Dual-tracer PET-CT detected metastasis in 17 patients (11%). By multivariate analysis, alpha-fetoprotein (AFP) ≥400 ng/mL [relative risk (RR): 4.30, 95% confidence interval (CI): 1.41–13.15, P=0.011] and bilobar disease (RR: 3.94, 95% CI: 1.24–12.52, P=0.014) were independent predictive factors for PET-detected metastasis. PET-CT findings altered the treatment strategy for 12 patients (7.9%); three partial hepatectomies, eight episodes of transarterial chemoembolization (TACE) and one episode of ablation were avoided, with an estimated cost-saving of US $91,000, $150,000 and $10,600 respectively. Had the PET-CT been performed only for patients with AFP ≥400 ng/mL or bilobar disease (n=74), metastasis would have been confirmed in 14 patients (18.9%), and the cost-saving per patient was estimated at US $1,070. Conclusions: Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP ≥400 ng/mL or bilobar disease. Its routine use in preoperative workup for all HCC patients is not recommended. Unilobar disease with AFP
- Published
- 2021
16. Creating Intellectual Capital through a Learning-Driven Knowledge Management System in a Hong Kong School
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Alex K. W. Chu
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- 2022
17. First Integration of 10-V CMOS Logic Circuit, 20-V Gate Driver, and 600-V VDMOSFET on a 4H-SiC Single Chip
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B. Y. Tsui, C. L. Hung, T. K. Tsai, Y. C. Tsui, T. W. Wang, Y. X. Wen, C. P. Shih, J. C. Wang, L. J. Lin, C. H. Wang, K. W. Chu, and P. H. Chen
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- 2022
18. Expanding Indications for Liver Transplant: Tumor and Patient Factors
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Kenneth S. H. Chok, Kevin K. W. Chu, and Kelly Hiu Ching Wong
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medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,Review ,Milan criteria ,Living donor ,Organ transplantation ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Living Donors ,medicine ,Humans ,Intensive care medicine ,Liver transplant ,Aged ,Patient factors ,Hepatology ,business.industry ,Liver Neoplasms ,Gastroenterology ,medicine.disease ,Surgical indication ,Liver Transplantation ,Patient management ,Bile Ducts, Intrahepatic ,surgical procedures, operative ,Bile Duct Neoplasms ,Treatment modality ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Neoplasm Recurrence, Local ,business - Abstract
During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding ever since. The aim of this review is to provide an overview of such an expansion of scope. Various criteria have been proposed to expand the eligibility of patients with hepatocellular carcinoma exceeding the Milan criteria for liver transplant. Furthermore, liver transplant is increasingly performed as a treatment modality for cholangiocarcinoma, neuroendocrine liver metastasis and colorectal liver metastasis. The number of elderly patients receiving liver transplant is on the rise. Combined organ transplantation has also been adopted to treat patients with multiple organ failure. Going forward, further development of preoperative noninvasive predictors in tumor, patient and even donor factors is needed to identify patients at risk of poor outcomes and hence optimize patient management.
- Published
- 2021
19. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Dromedary Camels in Africa and Middle East
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Ahmed Kandeil, Mokhtar Gomaa, Ahmed Nageh, Mahmoud M. Shehata, Ahmed E. Kayed, Jamal S. M. Sabir, Awatef Abiadh, Jamel Jrijer, Zuhair Amr, Mounir Abi Said, Denis K. Byarugaba, Fred Wabwire-Mangen, Titus Tugume, Nadira S. Mohamed, Roba Attar, Sabah M. Hassan, Sabah Abdulaziz Linjawi, Yassmin Moatassim, Omnia Kutkat, Sara Mahmoud, Ola Bagato, Noura M. Abo Shama, Rabeh El-Shesheny, Ahmed Mostafa, Ranawaka A. P. M. Perera, Daniel K. W. Chu, Nagla Hassan, Basma Elsokary, Ahmed Saad, Heba Sobhy, Ihab El Masry, Pamela P. McKenzie, Richard J. Webby, Malik Peiris, Yilma J. Makonnen, Mohamed A. Ali, and Ghazi Kayali
- Subjects
MERS coronavirus ,surveillance ,virus infection ,epidemiology ,virus transmission ,Microbiology ,QR1-502 - Abstract
Dromedary camels are the natural reservoirs of the Middle East respiratory syndrome coronavirus (MERS-CoV). Camels are mostly bred in East African countries then exported into Africa and Middle East for consumption. To understand the distribution of MERS-CoV among camels in North Africa and the Middle East, we conducted surveillance in Egypt, Senegal, Tunisia, Uganda, Jordan, Saudi Arabia, and Iraq. We also performed longitudinal studies of three camel herds in Egypt and Jordan to elucidate MERS-CoV infection and transmission. Between 2016 and 2018, a total of 4027 nasal swabs and 3267 serum samples were collected from all countries. Real- time PCR revealed that MERS-CoV RNA was detected in nasal swab samples from Egypt, Senegal, Tunisia, and Saudi Arabia. Microneutralization assay showed that antibodies were detected in all countries. Positive PCR samples were partially sequenced, and a phylogenetic tree was built. The tree suggested that all sequences are of clade C and sequences from camels in Egypt formed a separate group from previously published sequences. Longitudinal studies showed high seroprevalence in adult camels. These results indicate the widespread distribution of the virus in camels. A systematic active surveillance and longitudinal studies for MERS-CoV are needed to understand the epidemiology of the disease and dynamics of viral infection.
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- 2019
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20. Wikiglass: a learning analytic tool for visualizing collaborative wikis of secondary school students.
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Xiao Hu 0001, Jason Ip, Koossulraj Sadaful, George Lui, and Sam K. W. Chu
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- 2016
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21. Affordances and Constraints of a Wiki for Primary-school Students? Group Projects.
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Huijuan Fu, Samuel K. W. Chu, and Wenxia Kang
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- 2013
22. Quantification of Influenza Virus RNA in Aerosols in Patient Rooms.
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Nancy H L Leung, Jie Zhou, Daniel K W Chu, Han Yu, William G Lindsley, Donald H Beezhold, Hui-Ling Yen, Yuguo Li, Wing-Hong Seto, Joseph S M Peiris, and Benjamin J Cowling
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Medicine ,Science - Abstract
The potential for human influenza viruses to spread through fine particle aerosols remains controversial. The objective of our study was to determine whether influenza viruses could be detected in fine particles in hospital rooms.We sampled the air in 2-bed patient isolation rooms for four hours, placing cyclone samplers at heights of 1.5m and 1.0m. We collected ten air samples each in the presence of at least one patient with confirmed influenza A virus infection, and tested the samples by reverse transcription polymerase chain reaction. We recovered influenza A virus RNA from 5/10 collections (50%); 4/5 were from particles>4 μm, 1/5 from 1-4 μm, and none in particles
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- 2016
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23. Vehicular fuel composition and atmospheric emissions in South China: Hong Kong, Macau, Guangzhou, and Zhuhai
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W. Y. Tsai, L. Y. Chan, D. R. Blake, and K. W. Chu
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Vehicular emission is an important source of air pollutants in urban cities in the Pearl River Delta (PRD) region of South China. In order to study the impact of evaporative loss of vehicular fuel on air quality, several commonly used fuel samples were collected in four main cities in the PRD region – Hong Kong, Guangzhou, Macau and Zhuhai, and analyzed for their volatile organic compounds (VOCs) composition. Source profiles of vapors of the vehicular fuels used in these cities were constructed and are believed to be the first reported for the PRD region. The C8-C10 hydrocarbons were the main constituents of diesel. Different from diesel, gasoline used in the PRD region was mainly comprised of lighter C4-C7 hydrocarbons, with toluene and i-pentane being the two most abundant species. The toluene content in the Hong Kong and Macau gasoline samples were higher than that in Guangzhou and Zhuhai, while the reverse was true for the benzene content. The benzene levels in Guangzhou and Zhuhai exceeded the maximum allowable benzene levels for Mainland China unleaded gasoline. Liquefied Petroleum Gas (LPG) samples were collected only in Hong Kong and were comprised mainly of n-butane, propane and i-butane. Traffic samples indicated that evaporative loss and vehicular combustion were the primary contributors to elevated VOC levels in roadside atmospheres. Significant i-pentane and toluene concentrations were observed in roadside atmospheres in all four cities. Ratio of i-pentane in gasoline vapors to that in roadside samples were calculated and this showed that the degree of evaporative loss were higher in Guangzhou and Zhuhai than that in Hong Kong and Macau. We suggest the difference is due to the better maintenance and more new cars in Hong Kong and Macau. From tunnel samples collected in Hong Kong in two different years, we found that the relative amount of propane, i-butane, and n-butane increased between 2001 to 2003, consistent with the 40% increase in LPG fueled vehicles. Propane to butanes ratios were calculated for LPG samples and tunnels samples, and the comparable ratios illustrated the LPG leakages from LPG fueled vehicles crossing the tunnel.
- Published
- 2006
24. Managing Knowledge For Global And Collaborative Innovations
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Samuel K W Chu, Waltraut Ritter, Suliman Hawamdeh and Samuel K W Chu, Waltraut Ritter, Suliman Hawamdeh
- Published
- 2009
25. Is the treatment outcome of hepatocellular carcinoma inferior in elderly patients?
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Kevin K. W. Chu and Kenneth S. H. Chok
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Oncology ,Radiofrequency ablation ,Hepatocellular carcinoma ,medicine.medical_treatment ,health care facilities, manpower, and services ,Treatment outcome ,Comorbidity ,Liver transplantation ,law.invention ,0302 clinical medicine ,law ,Molecular Targeted Therapy ,Aged, 80 and over ,Clinical outcome ,Liver Neoplasms ,Gastroenterology ,Age Factors ,Treatment options ,Minireviews ,General Medicine ,Middle Aged ,Sorafenib ,humanities ,Survival Rate ,Treatment Outcome ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,medicine.drug ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Antineoplastic Agents ,Disease-Free Survival ,03 medical and health sciences ,Internal medicine ,medicine ,Hepatectomy ,Humans ,Chemoembolization, Therapeutic ,neoplasms ,Aged ,Radiofrequency Ablation ,business.industry ,Patient Selection ,social sciences ,medicine.disease ,digestive system diseases ,Liver Transplantation ,Life expectancy ,Surgery ,business - Abstract
In view of the increasing life expectancy in different parts of the world, a larger proportion of elderly patients with hepatocellular carcinoma (HCC) requiring oncological treatment is expected. The clinicopathological characteristics of HCC in elderly patients and in younger patients are different. Elderly patients, in general, also have more comorbidities. Evaluation of the efficacy of different HCC treatment options in elderly patients is necessary to optimize treatment outcomes for them. Treatment modalities for HCC include hepatectomy, liver transplantation, radiofrequency ablation, transarterial chemoembolization, and molecular-targeted therapy with sorafenib. In this review, current evidence on the risks and outcomes of the different HCC treatments for elderly patients are discussed. According to data in the literature, elderly patients and younger patients benefited similarly from HCC treatments. More clinical data are needed for the determination of selecting criteria on elderly HCC patients to maximize their chance of getting the most appropriate and effective treatments. As such, further studies evaluating the outcomes of different HCC treatment modalities in elderly patients are warranted.
- Published
- 2019
26. Wiki-based Collaborative Writing: A Comparative Study on First and Second Language Writing among Chinese Secondary Students
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Samuel K. W. Chu, Jean H. Y. Lai, Jing Wu, and Crystal W. S. Kwan
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Collaborative writing ,Second language writing ,Computer science ,Mathematics education ,Computer Science Applications ,Education - Published
- 2019
27. Inferring influenza infection attack rate from seroprevalence data.
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Joseph T Wu, Kathy Leung, Ranawaka A P M Perera, Daniel K W Chu, Cheuk Kwong Lee, Ivan F N Hung, Che Kit Lin, Su-Vui Lo, Yu-Lung Lau, Gabriel M Leung, Benjamin J Cowling, and J S Malik Peiris
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Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,QH301-705.5 - Abstract
Seroprevalence survey is the most practical method for accurately estimating infection attack rate (IAR) in an epidemic such as influenza. These studies typically entail selecting an arbitrary titer threshold for seropositivity (e.g. microneutralization [MN] 1∶40) and assuming the probability of seropositivity given infection (infection-seropositivity probability, ISP) is 100% or similar to that among clinical cases. We hypothesize that such conventions are not necessarily robust because different thresholds may result in different IAR estimates and serologic responses of clinical cases may not be representative. To illustrate our hypothesis, we used an age-structured transmission model to fully characterize the transmission dynamics and seroprevalence rises of 2009 influenza pandemic A/H1N1 (pdmH1N1) during its first wave in Hong Kong. We estimated that while 99% of pdmH1N1 infections became MN1∶20 seropositive, only 72%, 62%, 58% and 34% of infections among age 3-12, 13-19, 20-29, 30-59 became MN1∶40 seropositive, which was much lower than the 90%-100% observed among clinical cases. The fitted model was consistent with prevailing consensus on pdmH1N1 transmission characteristics (e.g. initial reproductive number of 1.28 and mean generation time of 2.4 days which were within the consensus range), hence our ISP estimates were consistent with the transmission dynamics and temporal buildup of population-level immunity. IAR estimates in influenza seroprevalence studies are sensitive to seropositivity thresholds and ISP adjustments which in current practice are mostly chosen based on conventions instead of systematic criteria. Our results thus highlighted the need for reexamining conventional practice to develop standards for analyzing influenza serologic data (e.g. real-time assessment of bias in ISP adjustments by evaluating the consistency of IAR across multiple thresholds and with mixture models), especially in the context of pandemics when robustness and comparability of IAR estimates are most needed for informing situational awareness and risk assessment. The same principles are broadly applicable for seroprevalence studies of other infectious disease outbreaks.
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- 2014
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28. Introduction of an in-house real-time PCR assay to detect severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) in Sri Lanka: challenges and issues
- Author
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Vigeetha Withanage, Jude Jayamaha, Daniel K W Chu, and Malik Peiris
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Real-time polymerase chain reaction ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pcr assay ,Medicine ,Sri lanka ,business ,Virology - Published
- 2020
29. Author response for 'A six‐plex droplet digital RT‐PCR assay for seasonal influenza virus typing, subtyping, and lineage determination'
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null Nathaniel K. C. Leong, null Daniel K. W. Chu, null Julie T. S. Chu, null Yat H. Tam, null Dennis K. M. Ip, null Benjamin J. Cowling, and null Leo L. M. Poon
- Published
- 2020
30. Multivariate analyses of codon usage of SARS-CoV-2 and other betacoronaviruses
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Leo L.M. Poon, Malik Peiris, Haogao Gu, and Daniel K W Chu
- Subjects
Multivariate analysis ,viruses ,coronavirus ,Disease ,Biology ,medicine.disease_cause ,Microbiology ,Virus ,03 medical and health sciences ,Virology ,medicine ,Gene ,030304 developmental biology ,Coronavirus ,chemistry.chemical_classification ,Genetics ,0303 health sciences ,Phylogenetic tree ,030306 microbiology ,Host (biology) ,SARS-CoV-2 ,virus diseases ,WCA ,medicine.disease ,Amino acid ,chemistry ,Codon usage bias ,Middle East respiratory syndrome ,codon usage analysis ,Rapid Communication - Abstract
Coronavirus disease 2019 (COVID-19) is a global health concern as it continues to spread within China and beyond. The causative agent of this disease, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), belongs to the genus Betacoronavirus, which also includes severe acute respiratory syndrome-related coronavirus (SARSr-CoV) and Middle East respiratory syndrome-related coronavirus (MERSr-CoV). Codon usage of viral genes are believed to be subjected to different selection pressures in different host environments. Previous studies on codon usage of influenza A viruses helped identify viral host origins and evolution trends, however, similar studies on coronaviruses are lacking. In this study, we compared the codon usage bias using global correspondence analysis (CA), within-group CA and between-group CA. We found that the bat RaTG13 virus best matched the overall codon usage pattern of SARS-CoV-2 in orf1ab, spike and nucleocapsid genes, while the pangolin P1E virus had a more similar codon usage in membrane gene. The amino acid usage pattern of SARS-CoV-2 was generally found similar to bat and human SARSr-CoVs. However, we found greater synonymous codon usage differences between SARS-CoV-2 and its phylogenetic relatives on spike and membrane genes, suggesting these two genes of SARS-CoV-2 are subjected to different evolutionary pressures.
- Published
- 2020
31. ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection
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Asmaa, Hachim, Niloufar, Kavian, Carolyn A, Cohen, Alex W H, Chin, Daniel K W, Chu, Chris K P, Mok, Owen T Y, Tsang, Yiu Cheong, Yeung, Ranawaka A P M, Perera, Leo L M, Poon, J S Malik, Peiris, and Sophie A, Valkenburg
- Subjects
Adult ,Male ,Time Factors ,Clinical Laboratory Techniques ,SARS-CoV-2 ,Pneumonia, Viral ,COVID-19 ,Middle Aged ,Antibodies, Viral ,Sensitivity and Specificity ,Antibodies ,Betacoronavirus ,Viral Proteins ,COVID-19 Testing ,Viral infection ,Hong Kong ,Humans ,Female ,Coronavirus Infections ,Author Correction ,Antigens, Viral ,Pandemics ,Aged - Abstract
The SARS-CoV-2 virus emerged in December 2019 and has caused a worldwide pandemic due to the lack of any pre-existing immunity. Accurate serology testing is urgently needed to help diagnose infection, determine past exposure of populations and assess the response to a future vaccine. The landscape of antibody responses to SARS-CoV-2 is unknown. In this study, we utilized the luciferase immunoprecipitation system to assess the antibody responses to 15 different SARS-CoV-2 antigens in patients with COVID-19. We identified new targets of the immune response to SARS-CoV-2 and show that nucleocapsid, open reading frame (ORF)8 and ORF3b elicit the strongest specific antibody responses. ORF8 and ORF3b antibodies, taken together as a cluster of points, identified 96.5% of COVID-19 samples at early and late time points of disease with 99.5% specificity. Our findings could be used to develop second-generation diagnostic tests to improve serological assays for COVID-19 and are important in understanding pathogenicity.
- Published
- 2020
32. Respiratory virus shedding in exhaled breath and efficacy of face masks
- Author
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Nancy H L, Leung, Daniel K W, Chu, Eunice Y C, Shiu, Kwok-Hung, Chan, James J, McDevitt, Benien J P, Hau, Hui-Ling, Yen, Yuguo, Li, Dennis K M, Ip, J S Malik, Peiris, Wing-Hong, Seto, Gabriel M, Leung, Donald K, Milton, and Benjamin J, Cowling
- Subjects
Aerosols ,Epidemiology ,Pneumonia, Viral ,Masks ,COVID-19 ,Orthomyxoviridae ,Virus Shedding ,Exhalation ,Humans ,RNA, Viral ,Infectious diseases ,Coronavirus Infections ,Author Correction ,Pandemics ,Respiratory Tract Infections - Abstract
We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness. Surgical face masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols, with a trend toward reduced detection of coronavirus RNA in respiratory droplets. Our results indicate that surgical face masks could prevent transmission of human coronaviruses and influenza viruses from symptomatic individuals.
- Published
- 2020
33. A Normative Knowledge Management Model for School Development
- Author
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Eric C. K. Cheng and C. K. W. Chu
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Knowledge management ,business.industry ,Political science ,0502 economics and business ,05 social sciences ,050301 education ,Normative ,business ,0503 education ,050203 business & management ,School development - Published
- 2018
34. Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data.
- Author
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Joseph T Wu, Andrew Ho, Edward S K Ma, Cheuk Kwong Lee, Daniel K W Chu, Po-Lai Ho, Ivan F N Hung, Lai Ming Ho, Che Kit Lin, Thomas Tsang, Su-Vui Lo, Yu-Lung Lau, Gabriel M Leung, Benjamin J Cowling, and J S Malik Peiris
- Subjects
Medicine - Abstract
In an emerging influenza pandemic, estimating severity (the probability of a severe outcome, such as hospitalization, if infected) is a public health priority. As many influenza infections are subclinical, sero-surveillance is needed to allow reliable real-time estimates of infection attack rate (IAR) and severity.We tested 14,766 sera collected during the first wave of the 2009 pandemic in Hong Kong using viral microneutralization. We estimated IAR and infection-hospitalization probability (IHP) from the serial cross-sectional serologic data and hospitalization data. Had our serologic data been available weekly in real time, we would have obtained reliable IHP estimates 1 wk after, 1-2 wk before, and 3 wk after epidemic peak for individuals aged 5-14 y, 15-29 y, and 30-59 y. The ratio of IAR to pre-existing seroprevalence, which decreased with age, was a major determinant for the timeliness of reliable estimates. If we began sero-surveillance 3 wk after community transmission was confirmed, with 150, 350, and 500 specimens per week for individuals aged 5-14 y, 15-19 y, and 20-29 y, respectively, we would have obtained reliable IHP estimates for these age groups 4 wk before the peak. For 30-59 y olds, even 800 specimens per week would not have generated reliable estimates until the peak because the ratio of IAR to pre-existing seroprevalence for this age group was low. The performance of serial cross-sectional sero-surveillance substantially deteriorates if test specificity is not near 100% or pre-existing seroprevalence is not near zero. These potential limitations could be mitigated by choosing a higher titer cutoff for seropositivity. If the epidemic doubling time is longer than 6 d, then serial cross-sectional sero-surveillance with 300 specimens per week would yield reliable estimates when IAR reaches around 6%-10%.Serial cross-sectional serologic data together with clinical surveillance data can allow reliable real-time estimates of IAR and severity in an emerging pandemic. Sero-surveillance for pandemics should be considered.
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- 2011
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35. Epidemiological characteristics of 2009 (H1N1) pandemic influenza based on paired sera from a longitudinal community cohort study.
- Author
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Steven Riley, Kin O Kwok, Kendra M Wu, Danny Y Ning, Benjamin J Cowling, Joseph T Wu, Lai-Ming Ho, Thomas Tsang, Su-Vui Lo, Daniel K W Chu, Edward S K Ma, and J S Malik Peiris
- Subjects
Medicine - Abstract
BackgroundWhile patterns of incidence of clinical influenza have been well described, much uncertainty remains over patterns of incidence of infection. The 2009 pandemic provided both the motivation and opportunity to investigate patterns of mild and asymptomatic infection using serological techniques. However, to date, only broad epidemiological patterns have been defined, based on largely cross-sectional study designs with convenience sampling frameworks.Methods and findingsWe conducted a paired serological survey of a cohort of households in Hong Kong, recruited using random digit dialing, and gathered data on severe confirmed cases from the public hospital system (>90% inpatient days). Paired sera were obtained from 770 individuals, aged 3 to 103, along with detailed individual-level and household-level risk factors for infection. Also, we extrapolated beyond the period of our study using time series of severe cases and we simulated alternate study designs using epidemiological parameters obtained from our data. Rates of infection during the period of our study decreased substantially with age: for 3-19 years, the attack rate was 39% (31%-49%); 20-39 years, 8.9% (5.3%-14.7%); 40-59 years, 5.3% (3.5%-8.0%); and 60 years or older, 0.77% (0.18%-4.2%). We estimated parameters for a parsimonious model of infection in which a linear age term and the presence of a child in the household were used to predict the log odds of infection. Patterns of symptom reporting suggested that children experienced symptoms more often than adults. The overall rate of confirmed pandemic (H1N1) 2009 influenza (H1N1pdm) deaths was 7.6 (6.2-9.5) per 100,000 infections. However, there was substantial and progressive increase in deaths per 100,000 infections with increasing age from 0.66 (0.65-0.86) for 3-19 years up to 220 (50-4,000) for 60 years and older. Extrapolating beyond the period of our study using rates of severe disease, we estimated that 56% (43%-69%) of 3-19 year olds and 16% (13%-18%) of people overall were infected by the pandemic strain up to the end of January 2010. Using simulation, we found that, during 2009, larger cohorts with shorter follow-up times could have rapidly provided similar data to those presented here.ConclusionsShould H1N1pdm evolve to be more infectious in older adults, average rates of severe disease per infection could be higher in future waves: measuring such changes in severity requires studies similar to that described here. The benefit of effective vaccination against H1N1pdm infection is likely to be substantial for older individuals. Revised pandemic influenza preparedness plans should include prospective serological cohort studies. Many individuals, of all ages, remained susceptible to H1N1pdm after the main 2009 wave in Hong Kong. Please see later in the article for the Editors' Summary.
- Published
- 2011
- Full Text
- View/download PDF
36. Tailoring the Venous Outflow for a Modified Right Posterior Section Graft in Living Donor Liver Transplantation
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Nicklaus Kotewall, Jeff W.C. Dai, Albert C. Y. Chan, Brian Wong Hoi She, Kevin K. W. Chu, and Sui Ling Sin
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Liver surgery ,Transplantation ,Right hepatic vein ,medicine.medical_specialty ,Hepatology ,business.industry ,medicine.medical_treatment ,Section (typography) ,Vein graft ,Liver transplantation ,Surgery ,medicine ,Right posterior ,Living donor liver transplantation ,business - Published
- 2020
37. Fabrication of graphene from graphite by a thermal assisted vacuum arc discharge system
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Kevin K. W. Chu, Guo-Wei Cheng, Jeng Shiung Chen, and Jeff T. H. Tsai
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Fabrication ,Materials science ,business.industry ,Graphene ,Graphene foam ,Physics::Optics ,02 engineering and technology ,Chemical vapor deposition ,Vacuum arc ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,law.invention ,law ,Optoelectronics ,General Materials Science ,Graphite ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Graphene nanoribbons ,Graphene oxide paper - Abstract
In this study, graphene was fabricated on copper foils using a high temperature furnace embedded in a vacuum arc discharge method. Combining the advantages of chemical vapor deposition and vacuum arc discharge, single-layer graphene can be fabricated at 600 °C base temperature from the mini furnace embedded with a fast heating via the photon radiation from the vacuum arc to 1100 °C on the substrates' surface. The optimal fabrication condition was determined through a series of experiments on ambient pressure, processing time, arc currents, and the cooling process. Observations by scanning electron microscopy, Raman spectroscopy, and optical microscopy showed that the main products were single-layer graphene, which has a uniform thickness across the entire substrate. The results demonstrated that the combination of a vacuum arc with a thermal method that uses graphite as a carbon source provides a low-cost and straight forward method to synthesize graphene films for graphene-based applications.
- Published
- 2017
38. Graphene-edge probes for scanning tunneling microscopy
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Kevin K. W. Chu, Jeng Shiung Chen, Jeff T. H. Tsai, and Li-Der Chang
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Microscope ,Materials science ,Graphene ,Nanotechnology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electrochemical scanning tunneling microscope ,Electronic, Optical and Magnetic Materials ,law.invention ,Field electron emission ,Scanning probe microscopy ,law ,0103 physical sciences ,Microscopy ,Electrical and Electronic Engineering ,Scanning tunneling microscope ,010306 general physics ,0210 nano-technology ,Graphene nanoribbons - Abstract
Freestanding graphene-edge probes for scanning tunneling microscopy were demonstrated. Graphene was prepared on a Cu wire by thermal chemical vapor deposition (CVD) from solid carbon sources. Follow by a mechanical cutting process which was controlled by a micromanipulator and an optical microscope. The freestanding graphene probes were then fabricated. Our previous study of electron emission patterns from a field emission microscope demonstrated the layered structure of the graphene edge. We found that a single-layer of graphene emitted electrons comes from a limited number of atoms only when the graphene probe was conditioning carefully to achieve a stable emission current. In this research, we applied such activated graphene probes for use in scanning tunneling microscopes for surface morphology detection. The preconditioned, multi-layer graphene probe presented well resolution that was comparable to conventional Pt-Ir probes. Our study generated a practical method for applying individual freestanding graphene for surface probe microscopy with a cost effective process.
- Published
- 2017
39. Plasma Epstein–Barr viral DNA load at midpoint of radiotherapy course predicts outcome in advanced-stage nasopharyngeal carcinoma
- Author
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Brigette B.Y. Ma, Yuk Ming Dennis Lo, Anthony T.C. Chan, Sing Fai Leung, Frankie Kf Mo, Edwin P. Hui, Kwan Chee Chan, Linda K.S. Leung, Benny Zee, K. W. Chu, and Kathy Chow
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Male ,Oncology ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,medicine.medical_specialty ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Real-Time Polymerase Chain Reaction ,Radiation Tolerance ,Disease-Free Survival ,Internal medicine ,Biomarkers, Tumor ,medicine ,Adjuvant therapy ,Humans ,Stage (cooking) ,Proportional Hazards Models ,Nasopharyngeal Carcinoma ,business.industry ,Carcinoma ,Hazard ratio ,Nasopharyngeal Neoplasms ,Chemoradiotherapy ,Hematology ,Viral Load ,Prognosis ,medicine.disease ,Surgery ,Radiation therapy ,Treatment Outcome ,Real-time polymerase chain reaction ,Nasopharyngeal carcinoma ,DNA, Viral ,Biomarker (medicine) ,Female ,business - Abstract
BACKGROUND To test the hypothesis that prognostication of treatment outcome is feasible by biomarker response at midcourse of chemoradiotherapy (CRT)/radiotherapy (RT), with respect to the plasma load of Epstein-Barr viral (EBV) DNA in nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS One hundred seven patients with stage IIB-IV NPC were prospectively studied. Plasma EBV DNA load was measured by quantitative PCR before therapy (pre-DNA), at completion of 4 weeks of CRT/RT (mid-DNA), and within 3 months of completion of therapy (post-DNA). The end points are post-DNA load, a recognized surrogate of survival, and clinical outcome. RESULTS Ninety-three percent of patients had detectable EBV DNA before therapy (median load = 972 copies/ml). EBV DNA became undetectable in 55 (51%) patients at the end of week 4 of therapy. Detectable mid-DNA was associated with worse clinical outcome (median follow-up time, 6.2 years), for distant failure [hazard ratio (HR) 12.02, 95% confidence interval (CI) 2.78-51.93; P < 0.0001], progression-free survival (PFS; HR 4.05, 95% CI 1.89-8.67, P < 0.0001), and overall survival (OS; HR 3.29, 95% CI 1.37-7.90, P = 0.0077). Seventy-four percent of all failures were associated with detectable mid-DNA, whereas 34% of all failures were associated with detectable post-DNA. Stratification by tumor stage (IIB, III, IV) has no significant prognostic effect. CONCLUSIONS Unfavorable EBV DNA response at midcourse of RT/CRT is an adverse prognosticator for treatment outcome, is linked to majority of all failures, and discriminates outcome better than tumor stage. The data could provide a basis for trial design that addresses alteration of therapy intensity during the latter phase of CRT, and adjuvant therapy. Validation studies are awaited.
- Published
- 2014
40. Lipid profiles of donors and recipients of liver transplant: like father like son
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Chung Mau Lo, Kevin K. W. Chu, Kenneth S. H. Chok, Albert C. Y. Chan, See Ching Chan, Sui Ling Sin, and Ignatius K.P. Cheng
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Blood Glucose ,Male ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Liver transplantation ,Gastroenterology ,Body Mass Index ,chemistry.chemical_compound ,Fathers ,0302 clinical medicine ,Living Donors ,Prevalence ,Mass index ,Prospective Studies ,Child ,medicine.diagnostic_test ,Fasting ,Middle Aged ,Lipids ,Tissue Donors ,Child, Preschool ,030211 gastroenterology & hepatology ,Female ,Lipoproteins, HDL ,Immunosuppressive Agents ,Adult ,medicine.medical_specialty ,Adolescent ,03 medical and health sciences ,Young Adult ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Triglycerides ,Aged ,Dyslipidemias ,Retrospective Studies ,Hepatology ,Triglyceride ,business.industry ,medicine.disease ,Transplant Recipients ,Liver Transplantation ,Endocrinology ,chemistry ,Lipid profile ,business ,Body mass index ,Dyslipidemia ,Lipoprotein - Abstract
Dyslipidemia is common in liver transplant recipients. This retrospective study investigates whether donors play a role. Prospectively collected data of donors and recipients of deceased-donor liver transplantation (DDLT) and living-donor liver transplantation (LDLT) were reviewed. Total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein (HDL) and fasting glucose were compared between groups. HDL ≥1.6 mmol/L at 2 years after transplant was considered the marker of a favorable post-transplant lipid profile in recipients. Univariate and multivariate analyses were performed to identify predictive factors for this marker. There were 85 DDLTs and 80 LDLTs. LDLT donors were younger (30 vs. 50 years, p
- Published
- 2016
41. Special issue dedicated to Biswa Nath Datta on the occasion of his 70th birthday
- Author
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E. K-W. Chu, Lothar Reichel, and Wen-Wei Lin
- Subjects
Algebra and Number Theory ,Nath ,Applied Mathematics ,Classics ,Mathematics - Published
- 2013
42. Clinicopathologic predictors for early and late biochemical hypothyroidism after hemithyroidectomy
- Author
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Brian Hung-Hin Lang and Kevin K. W. Chu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Delayed Diagnosis ,Time Factors ,Adolescent ,Biochemical Phenomena ,medicine.medical_treatment ,Thyrotropin ,Kaplan-Meier Estimate ,Thyroid Function Tests ,Risk Assessment ,Gastroenterology ,Thyroiditis ,Cohort Studies ,Young Adult ,Postoperative Complications ,Hypothyroidism ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Thyroid Neoplasms ,Thyroid cancer ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,business.industry ,Incidence ,Incidence (epidemiology) ,Thyroidectomy ,General Medicine ,Middle Aged ,medicine.disease ,Anti-thyroid autoantibodies ,Surgery ,Early Diagnosis ,Concomitant ,Multivariate Analysis ,Female ,business ,Complication ,Follow-Up Studies - Abstract
Biochemical hypothyroidism (BH) after hemithyroidectomy is an under-recognized complication with a reported incidence of 9% to 43%. This study aimed to identify potential clinicopathologic risk factors associated with early (12 months after hemithyroidectomy) and late-onset (≥12 months after hemithyroidectomy) BH.From 2005 to 2008 there were 263 postsurgical patients who were eligible for analysis. Serum thyroid stimulating hormone (TSH) level was checked regularly after surgery. Postoperative TSH reaching a level higher than 5.5 mIU/L was defined as BH. The overall median follow-up period was 21 months (range, 3-62 mo). Any clinicopathologic factors significantly associated with BH in the univariate analysis were entered into multivariate analysis. A further analysis was performed comparing factors between early and late-onset BH.There were 38 patients who developed subsequent BH, 33 of these cases developed within 2 years. Those patients with BH were significantly older (P = .037), had a higher preoperative TSH level (P.001), longer follow-up period (P.001), more frequent thyroiditis on histology (P = .043), lighter resected tissue weight (P = .001), and were more likely to have positive antimicrosomal antibodies (P = .043) than those without BH. However, in the multivariate analysis after adjusting for different follow-up periods in the 2 groups, only lighter resected tissue weight (P = .036) and concomitant thyroiditis on histology (P = .005) turned out to be independent factors for BH. Thyroiditis on histology was also the only significant risk factor for developing early onset BH.Patients with lighter resected tissue weight and concomitant thyroiditis on histology were particularly at risk for subsequent BH. Although not all patients with thyroiditis developed BH, in those who did develop BH it occurred within the first 11 months.
- Published
- 2012
43. Freestanding graphene edge probes for scanning tunneling microscope
- Author
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Jeff T. H. Tsai and Kevin K. W. Chu
- Subjects
Microscope ,Materials science ,business.industry ,Graphene ,law.invention ,Field emission microscopy ,Optical microscope ,law ,Microscopy ,Optoelectronics ,Scanning tunneling microscope ,business ,Graphene nanoribbons ,Graphene oxide paper - Abstract
We demonstrated the fabrication of individual freestanding graphene edge probes. Graphene was prepared by thermal CVD with solid carbon sources. A Cu wire was act as the substrate for graphene growth. Follow the structure process from a micromanipulator and an optical microscope, the freestanding graphene probes was fabricated. The electron emission pattern from the graphene edge was observed, and a layered structure could be identified from field emission microscopy. The single-layer graphene emitted electrons from limited number of atoms. The graphene emitters required careful conditioning to achieve a stable emission current. Such graphene probes were applied in scanning tunneling microscopes for surface morphology detection. A preconditioned, multi-layer graphene probe presented well resolution compared with a conventional tungsten probe. Our study reveals a practical method by individual freestanding graphene in application for surface probe microscopy.
- Published
- 2015
44. Pole assignment for linear and quadratic systems with time-delay in control
- Author
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Tiexiang Li and E. K-W. Chu
- Subjects
Algebra and Number Theory ,Quadratic equation ,Robustness (computer science) ,Control theory ,Applied Mathematics ,Control system ,Linear system ,Applied mathematics ,Quadratic system ,Invariant (mathematics) ,Linear subspace ,Eigenvalues and eigenvectors ,Mathematics - Abstract
SUMMARY We consider the pole assignment problems for time-invariant linear and quadratic control systems, with time-delay in the control. Closed-loop eigenvectors in X D Œx1, x2, ��� � are chosen from their corresponding invariant subspaces, possibly optimizing some robustness measure, and explicit expressions for the feedback matrices are given in terms of X. Condition of the problems is also investigated. Our approach extends the well-known Kautsky, Nichols, and Van Dooren algorithm. Consequently, the results are similar to those for systems without time-delay, except for the presence of the ‘secondary’ eigenvalues and the condition of the problems. Simple illustrative numerical examples are given. Copyright © 2011 John Wiley & Sons, Ltd.
- Published
- 2011
45. Update in management of hepatocellular carcinoma in Eastern population
- Author
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Tan To Cheung and Kevin K. W. Chu
- Subjects
medicine.medical_specialty ,education.field_of_study ,Cirrhosis ,Hepatology ,business.industry ,medicine.medical_treatment ,Population ,Review ,Liver transplantation ,Chronic liver disease ,medicine.disease ,Gastroenterology ,digestive system diseases ,Internal medicine ,Hepatocellular carcinoma ,medicine ,Liver function ,Radiology ,Hepatectomy ,business ,Liver cancer ,education ,neoplasms - Abstract
Hepatocellular carcinoma (HCC) is one of the commonest malignant tumours in the East. Although the management of HCC in the West is mainly based on the Barcelona Clinic for Liver Cancer staging, it is considered too conservative by Asian countries where the number of HCC patients is huge. Scientific and clinical advances were made in aspects of diagnosis, staging, and treatment of HCC. HCC is well known to be associated with cirrhosis and the treatment of HCC must take into account the presence and stage of chronic liver disease. The major treatment modalities of HCC include: (1) surgical resection; (2) liver transplantation; (3) local ablation therapy; (4) transarterial locoregional treatment; and (5) systemic treatment. Among these, resection, liver transplantation and ablation therapy for small HCC are considered as curative treatment. Portal vein embolisation and the associating liver partition with portal vein ligation for staged hepatectomy may reduce dropout in patients with marginally resectable disease but the midterm and long-term results are still to be confirmed. Patient selection for the best treatment modality is the key to success of treatment of HCC. The purpose of current review is to provide a description of the current advances in diagnosis, staging, preoperative liver function assessment and treatment options for patients with HCC in the east. © 2015 Baishideng Publishing Group Inc., published_or_final_version
- Published
- 2015
46. Determination of the small-field output factor for 6 MV photon beam using EGSnrc Monte Carlo
- Author
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K W Chuah, M Z Abdul Aziz, and J Jayamani
- Subjects
collimator scatter factor ,phantom scatter factor ,linear accelerator ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Accuracy of ionization chamber (IC) to measure the scatter output factor (Scp) of a linear accelerator (linac) is crucial, especially in small field (
- Published
- 2022
- Full Text
- View/download PDF
47. A generalized structure-preserving doubling algorithm for generalized discrete-time algebraic Riccati equations
- Author
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Eric K-W Chu, Wen-Wei Lin, and T-M Hwang
- Subjects
Discrete mathematics ,Discrete time and continuous time ,Control and Systems Engineering ,Structure (category theory) ,Algebraic number ,Cayley transformation ,Algorithm ,Computer Science Applications ,Mathematics ,Symplectic geometry - Abstract
In Chu et al. (2004), an efficient structure-preserving doubling algorithm (SDA) was proposed for the solution of discrete-time algebraic Riccati equations (DAREs). In this paper, we generalize the SDA to the G-SDA, for the generalized DARE: E T XE = A T XA − (A T XB…+C TS )(R + B T XB)−1(B T XA + S TC ) + C T QC. Using Cayley transformation twice, we transform the generalized DARE to a DARE in a standard symplectic form without any explicit inversions of (possibly ill-conditioned) R and E. The SDA can then be applied. Selected numerical examples illustrate that the G-SDA is efficient, out-performing other algorithms.
- Published
- 2005
48. Structure-Preserving Algorithms for Periodic Discrete-Time Algebraic Riccati Equations
- Author
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Chern Shuh Wang, Hung Yuan Fan, Wen-Wei Lin, and Eric K-W Chu
- Subjects
Rate of convergence ,Discrete time and continuous time ,Control and Systems Engineering ,Algebraic number ,Algorithm ,Swap (computer programming) ,Symplectic matrix ,Computer Science Applications ,Symplectic geometry ,Mathematics ,Algebraic Riccati equation - Abstract
In this paper we investigate structure-preserving algorithms for computing the symmetric positive semi-definite solutions to the periodic discrete-time algebraic Riccati equations (P-DAREs). Using a structure-preserving swap and collapse procedure, a single symplectic matrix pair in standard symplectic form is obtained. The P-DAREs can then be solved via a single DARE, using a structure-preserving doubling algorithm. We develop the structure-preserving doubling algorithm from a new point of view and show its quadratic convergence under assumptions which are weaker than stabilizability and detectability. With several numerical results, the algorithm is shown to be efficient, out-performing other algorithms on a large set of benchmark problems.
- Published
- 2004
49. A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population
- Author
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C. K. Chan, B. C. Y. Wong, Whc Hu, Teresa Tong, Kam Chuen Lai, Graeme P. Young, Wai Man Wong, K. W. Chu, H. M. Tung, W. L. Law, Paul Rozen, K. L. Cheung, S. K. Lam, and J. Ho
- Subjects
medicine.medical_specialty ,Hepatology ,medicine.diagnostic_test ,Colorectal cancer ,business.industry ,Incidence (epidemiology) ,Gastroenterology ,Colonoscopy ,Rectum ,medicine.disease ,Test (assessment) ,medicine.anatomical_structure ,Internal medicine ,Epidemiology ,medicine ,Pharmacology (medical) ,Blood culture ,business ,Mass screening - Abstract
Summary Background : Colorectal cancer screening by guaiac faecal occult blood test has been shown to reduce the incidence and mortality of colorectal cancer in Western populations. The optimal faecal occult blood test, whether guaiac or immunochemical, for colorectal cancer screening in the Chinese population remains to be defined. Aim : To compare the performance characteristics of a sensitive guaiac-based faecal occult blood test (Hemoccult SENSA) and an immunochemical faecal occult blood test (FlexSure OBT) in a Chinese population referred for colonoscopy. Methods : One hundred and thirty-five consecutive patients who were referred for colonoscopy and who met the study inclusion criteria took samples for the two faecal occult blood tests simultaneously from three successive stool specimens, with no dietary restrictions. All tests were developed and interpreted by a single experienced technician who was blind to the clinical diagnosis. The sensitivity, specificity and positive predictive value for the detection of colorectal adenomas and cancers were estimated for the two tests. Results : The sensitivity, specificity and positive predictive value for the detection of significant colorectal neoplasia (adenomas ≥ 1.0 cm and cancers) were 91%, 70% and 18% for Hemoccult SENSA and 82%, 94% and 47% for FlexSure OBT. The specificity and positive predictive value were significantly higher for FlexSure OBT than for Hemoccult SENSA (P
- Published
- 2003
50. POLE ASSIGNMENT FOR SECOND-ORDER SYSTEMS
- Author
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Eric K-W Chu
- Subjects
Mechanical Engineering ,Aerospace Engineering ,Computer Science Applications ,Second order systems ,Combinatorics ,Quadratic equation ,Control and Systems Engineering ,Robustness (computer science) ,Control system ,Signal Processing ,Singular value decomposition ,Assignment problem ,Eigenvalues and eigenvectors ,Pencil (mathematics) ,Civil and Structural Engineering ,Mathematics - Abstract
This paper contains some results for pole assignment problems for the second-order system M x (t)+D x (t)+K x (t)=B u (t) . Specifically, Algorithm 0 constructs feedback matrices F1 and F2 such that the closed-loop quadratic pencil Pc(λ)=λ2M+λ (D+BF2)+(K+BF1) has a desired set of eigenvalues and the associated eigenvectors are well-conditioned. The method is a modification of the SVD-based method proposed by Juang and Maghami [1, 2] which is a second-order adaptation of the well-known robust eigenvalue assignment method by Kautsky et al. [3] for first-order systems. Robustness is achieved by minimising some not-so-well-known condition numbers of the eigenvalues of the closed-loop second-order pencil. We next consider the partial pole assignment problem. In 1997, Datta, Elhay and Ram proposed three biorthogonality relations for eigenvectors of symmetric definite quadratic pencils [4]. One of these relations was used to derive an explicit solution to the partial pole assignment problem by state feedback for the related single-input symmetric definite second-order control system. The solution shed new light on the stabilisation and control of large flexible space structures, for which only one small subset of the spectrum needs to be reassigned while retaining the complementary part of the spectrum. In this paper, the method has been generalised for multi-input and non-symmetric quadratic pencils. Finally, we discuss briefly the output feedback pole assignment problem.
- Published
- 2002
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