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3 results on '"K Patel, Sonal"'

1. Clinical Management of Oral Lichen Planus: A Systematic Review

Author

J Dickmann, Leslie, K Patel, Sonal, C Wienkers, Larry, Slatter, J Greg, Lucchese, Alberta, Petruzzi, Massimo, Carinci, Francesco, Oberti, Luca, Lauritano, Dorina, J Dickmann, L, K Patel, S, C Wienkers, L, Slatter, J, Lucchese, A, Petruzzi, M, Carinci, F, Oberti, L, and Lauritano, D

Subjects
Administration, Topical, Psychological intervention, OLP treatment, Cytochrome P450, law.invention, 030207 dermatology & venereal diseases, 0302 clinical medicine, Randomized controlled trial, Calcineurin inhibitor, law, Drug Discovery, Randomized Controlled Trials as Topic, media_common, Calcineurin, Lichen Planus, MED/28 - MALATTIE ODONTOSTOMATOLOGICHE, General Medicine, Photo-dynamic therapy, Oral lichen planu, Topical, Oral lichen planus, Administration, Steroids, Active treatment, OLP randomized controlled trial, Oral, Drug, medicine.medical_specialty, OLP randomized controlled trials, media_common.quotation_subject, Calcineurin Inhibitors, Placebo, NO, 03 medical and health sciences, stomatognathic system, medicine, Humans, Steroid, Cytokine, Non pharmacological, Inflammation, Pharmacology, Interleukin-6, business.industry, 030206 dentistry, medicine.disease, Dermatology, Gene regulation, stomatognathic diseases, Photochemotherapy, Calcineurin inhibitors, Lichen Planus, Oral, business
Abstract

Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials & Methods: We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results: A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion: Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations.

Published
2019

2. Clinical management of oral lichen planus: A systematic review

Author

J Dickmann, L, K Patel, S, C Wienkers, L, Slatter, J, Lucchese, A, Petruzzi, M, Carinci, F, Oberti, L, Lauritano, D, J Dickmann, Leslie, K Patel, Sonal, C Wienkers, Larry, Slatter, J Greg, Lucchese, Alberta, Petruzzi, Massimo, Carinci, Francesco, Oberti, Luca, Lauritano, Dorina, J Dickmann, L, K Patel, S, C Wienkers, L, Slatter, J, Lucchese, A, Petruzzi, M, Carinci, F, Oberti, L, Lauritano, D, J Dickmann, Leslie, K Patel, Sonal, C Wienkers, Larry, Slatter, J Greg, Lucchese, Alberta, Petruzzi, Massimo, Carinci, Francesco, Oberti, Luca, and Lauritano, Dorina

Abstract

Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials and Methods: We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results: A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion: Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations.

Published
2019

3. Effects of Interleukin 1 (IL-1) and IL-1/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture

Author

J. Dickmann, Leslie, K. Patel, Sonal, C. Wienkers, Larry, and Greg Slatter, J.

Abstract

Exposure to cytokines can down-regulate hepatic cytochrome P450 enzymes. Accordingly, relief of inflammation by cytokinetargeted drug therapy has the potential to up-regulate cytochrome P450s and thereby increase clearance of co-administered drugs. This study examined the effects of the inflammatory cytokine, interleukin 1 (IL-1), and IL-1/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture. Treatment of hepatocytes with IL-1 revealed suppression of mRNA expression of several clinically important cytochrome P450 isoenzymes, with EC50 values that differed by isoenzyme. Suppression of CYP1A2 activity by IL-1 could not be measured in 3 of 5 donors due to lack of response, and in the two remaining donors the average EC50 was 450 pg/mL. CYP3A activity had an EC50 of suppression of 416 ± 454 pg/mL. Measurable EC50s were obtained for all 5 donors for CYP2C8, 3A4, 3A5, 4A11 and IL-6R mRNA with fold differences which varied between 9.5-fold (CYP2C8) to 109-fold (CYP4A11). When hepatocytes were treated with IL-1 and IL-6 in combination at concentrations which ranged from 1-100 pg/mL, IL-6 was the main determinant of increases in acute phase response marker mRNA and of decreases in CYP3A4 mRNA. There was no synergy between IL-1 and IL-6 in the regulation of cytochrome P450 mRNA when dosed in combination, although the effects of the two cytokines in combination were additive in certain instances. These data indicate that IL-1 and IL-6 both suppress cytochrome P450 mRNA and enzyme levels in vitro and that, at similar physiologically-relevant concentrations in vitro, IL-6 is more potent than IL-1.

Published
2012

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