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Background amd Objective: Periodontitis is a multifactorial disease in which environmental and genetic determinant factors contribute to individual subject’s susceptibility. A DNA polymorphism in the regulating region of adhesion molecule genes is suggested to modulate the molecule’s physiological effects. The aim of this study was to investigate the genetic association between the E-selectin Ser128Arg and L-selectin Phe206Leu polymorphisms and periodontitis. Material and Methods: DNA was isolated from the whole blood of 88 patients with periodontitis and 139 healthy individuals. All samples were genotyped for the E-selectin Ser128Arg and L-selectin Phe206Leu polymorphisms using the polymerase chain reaction with sequence specific primers. Results: Our findings revealed a significant difference in the Ser128Arg polymorphism of E-selectin, but not in the L-selectin polymorphism, between periodontal patients and controls. The 128Arg allele was present more frequently in patients than in healthy individuals (31.25% vs. 12.2%, p

Background and Objective: Periodontitis is a multifactorial disease and immunologic and genetic factors have an important role in its pathogenesis. Mutation in the promoter regions of the interleukin-4 and interferon-γ genes has been reported to modify the protein expression. The objective of this study was to evaluate the possible role of interleukin-4 (C-590T) and interferon-γ (G5644A) polymorphisms in the susceptibility to periodontitis. Material and Methods: In this case–control study, 53 patients (36 women and 17 men), comprising 27 patients with aggressive periodontitis and 26 patients with chronic periodontitis, and 56 healthy volunteers, were enrolled. DNA was isolated from all subjects, and the polymerase chain reaction-sequence specific primer method was used to study the interleukin-4 (C-590T) and interferon-γ (G5644A) gene polymorphisms. Results: Our results showed no significant difference in the allele and genotype frequencies of interleukin-4 (C-590T) and interferon-γ (G5644A) gene polymorphisms between patients with periodontal disease and controls. Conclusion: The results suggest that the interleukin-4 (C-590T) and interferon-γ (G5644A) gene polymorphisms may not be associated with the susceptibility of Iranian individuals to periodontitis.