Author: "Küpers, Leanne K." - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Küpers, Leanne K."' showing total 216 results

Start Over Author "Küpers, Leanne K."

216 results on '"Küpers, Leanne K."'

1. A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Author: Monasso, Giulietta S, Hoang, Thanh T, Mancano, Giulia, Fernández-Barrés, Sílvia, Dou, John, Jaddoe, Vincent WV, Page, Christian M, Johnson, Laura, Bustamante, Mariona, Bakulski, Kelly M, Håberg, Siri E, Ueland, Per M, Battram, Thomas, Merid, Simon K, Melén, Erik, Caramaschi, Doretta, Küpers, Leanne K, Sunyer, Jordi, Nystad, Wenche, Heil, Sandra G, Schmidt, Rebecca J, Vrijheid, Martine, Sharp, Gemma C, London, Stephanie J, and Felix, Janine F
Subjects: Biological Sciences, Genetics, Pediatric, Prevention, Nutrition, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, Infant, Newborn, Pregnancy, Child, Female, Humans, DNA Methylation, Epigenome, Birth Weight, Vitamin B 12, Epigenesis, Genetic, Fetal Blood, Vitamin B12, DNA methylation, epidemiology, cohort study, meta-analysis, PACE consortium, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Developmental Biology, Biochemistry and cell biology
Abstract: Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value
Published: 2023

2. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.

Author: Solomon, Olivia, Huen, Karen, Yousefi, Paul, Küpers, Leanne K, González, Juan R, Suderman, Matthew, Reese, Sarah E, Page, Christian M, Gruzieva, Olena, Rzehak, Peter, Gao, Lu, Bakulski, Kelly M, Novoloaca, Alexei, Allard, Catherine, Pappa, Irene, Llambrich, Maria, Vives, Marta, Jima, Dereje D, Kvist, Tuomas, Baccarelli, Andrea, White, Cory, Rezwan, Faisal I, Sharp, Gemma C, Tindula, Gwen, Bergström, Anna, Grote, Veit, Dou, John F, Isaevska, Elena, Magnus, Maria C, Corpeleijn, Eva, Perron, Patrice, Jaddoe, Vincent WV, Nohr, Ellen A, Maitre, Lea, Foraster, Maria, Hoyo, Cathrine, Håberg, Siri E, Lahti, Jari, DeMeo, Dawn L, Zhang, Hongmei, Karmaus, Wilfried, Kull, Inger, Koletzko, Berthold, Feinberg, Jason I, Gagliardi, Luigi, Bouchard, Luigi, Ramlau-Hansen, Cecilia Høst, Tiemeier, Henning, Santorelli, Gillian, Maguire, Rachel L, Czamara, Darina, Litonjua, Augusto A, Langhendries, Jean-Paul, Plusquin, Michelle, Lepeule, Johanna, Binder, Elisabeth B, Verduci, Elvira, Dwyer, Terence, Carracedo, Ángel, Ferre, Natalia, Eskenazi, Brenda, Kogevinas, Manolis, Nawrot, Tim S, Munthe-Kaas, Monica C, Herceg, Zdenko, Relton, Caroline, Melén, Erik, Gruszfeld, Dariusz, Breton, Carrie, Fallin, MD, Ghantous, Akram, Nystad, Wenche, Heude, Barbara, Snieder, Harold, Hivert, Marie-France, Felix, Janine F, Sørensen, Thorkild IA, Bustamante, Mariona, Murphy, Susan K, Raikkönen, Katri, Oken, Emily, Holloway, John W, Arshad, Syed Hasan, London, Stephanie J, and Holland, Nina
Subjects: Humans, DNA Methylation, Epigenesis, Genetic, Pregnancy, Sex Characteristics, Adolescent, Child, Infant, Newborn, Female, Male, Epigenomics, Epigenome, Children, Cord blood, DNA methylation, EWAS, Sex, Digestive Diseases, Human Genome, Genetics, Prevention, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Toxicology
Abstract: BackgroundAmong children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.MethodsWe performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5-10 years from 8 cohorts (n = 4268).ResultsIn newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p
Published: 2022

3. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Author: Vehmeijer, Florianne OL, Küpers, Leanne K, Sharp, Gemma C, Salas, Lucas A, Lent, Samantha, Jima, Dereje D, Tindula, Gwen, Reese, Sarah, Qi, Cancan, Gruzieva, Olena, Page, Christian, Rezwan, Faisal I, Melton, Philip E, Nohr, Ellen, Escaramís, Geòrgia, Rzehak, Peter, Heiskala, Anni, Gong, Tong, Tuominen, Samuli T, Gao, Lu, Ross, Jason P, Starling, Anne P, Holloway, John W, Yousefi, Paul, Aasvang, Gunn Marit, Beilin, Lawrence J, Bergström, Anna, Binder, Elisabeth, Chatzi, Leda, Corpeleijn, Eva, Czamara, Darina, Eskenazi, Brenda, Ewart, Susan, Ferre, Natalia, Grote, Veit, Gruszfeld, Dariusz, Håberg, Siri E, Hoyo, Cathrine, Huen, Karen, Karlsson, Robert, Kull, Inger, Langhendries, Jean-Paul, Lepeule, Johanna, Magnus, Maria C, Maguire, Rachel L, Molloy, Peter L, Monnereau, Claire, Mori, Trevor A, Oken, Emily, Räikkönen, Katri, Rifas-Shiman, Sheryl, Ruiz-Arenas, Carlos, Sebert, Sylvain, Ullemar, Vilhelmina, Verduci, Elvira, Vonk, Judith M, Xu, Cheng-jian, Yang, Ivana V, Zhang, Hongmei, Zhang, Weiming, Karmaus, Wilfried, Dabelea, Dana, Muhlhausler, Beverly S, Breton, Carrie V, Lahti, Jari, Almqvist, Catarina, Jarvelin, Marjo-Riitta, Koletzko, Berthold, Vrijheid, Martine, Sørensen, Thorkild IA, Huang, Rae-Chi, Arshad, Syed Hasan, Nystad, Wenche, Melén, Erik, Koppelman, Gerard H, London, Stephanie J, Holland, Nina, Bustamante, Mariona, Murphy, Susan K, Hivert, Marie-France, Baccarelli, Andrea, Relton, Caroline L, Snieder, Harold, Jaddoe, Vincent WV, and Felix, Janine F
Subjects: Biological Sciences, Genetics, Pediatric, Nutrition, Prevention, Human Genome, Obesity, 2.3 Psychological, social and economic factors, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Cardiovascular, Cancer, Stroke, Oral and gastrointestinal, Adolescent, Body Mass Index, Child, Child, Preschool, CpG Islands, Cross-Sectional Studies, DNA Methylation, Epigenesis, Genetic, Epigenome, Female, Fetal Blood, Humans, Male, Parturition, Pediatric Obesity, Pregnancy, Body mass index, Childhood obesity, DNA methylation, Epigenetics, Clinical Sciences
Abstract: BackgroundDNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits.MethodsWe examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment.ResultsDNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P
Published: 2020

4. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Author: Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C, Küpers, Leanne K, Kho, Alvin T, Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O, Kazmi, Nabila, Salas, Lucas A, Rezwan, Faisal I, Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L, Melton, Phillip E, Lawlor, Debbie A, Pershagen, Göran, Breton, Carrie V, Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S, Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L, Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M, Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A, Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L, Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W, Sørensen, Thorkild IA, Vrijheid, Martine, Arshad, S Hasan, Holloway, John W, Håberg, Siri E, Magnus, Per, Dwyer, Terence, Binder, Elisabeth B, DeMeo, Dawn L, Vonk, Judith M, Newnham, John, Tantisira, Kelan G, Kull, Inger, Wiemels, Joseph L, Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C, Räikkönen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T, Antó, Josep Maria, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E, Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F, Koppelman, Gerard H, London, Stephanie J, and Melén, Erik
Subjects: Humans, Premature Birth, DNA, DNA Methylation, Fetal Development, Adolescent, Child, Child, Preschool, Infant, Newborn, Infant, Premature, Female, Male, Genetic Loci, Epigenome, Development, Epigenetics, Gestational age, Preterm birth, Transcriptomics, Preschool, Infant, Newborn, Premature, Genetics, Clinical Sciences
Abstract: BackgroundPreterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children.MethodsWe performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung.ResultsWe identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P
Published: 2020

5. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Author: Küpers, Leanne K, Monnereau, Claire, Sharp, Gemma C, Yousefi, Paul, Salas, Lucas A, Ghantous, Akram, Page, Christian M, Reese, Sarah E, Wilcox, Allen J, Czamara, Darina, Starling, Anne P, Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie V, Allard, Catherine, Just, Allan C, Bakulski, Kelly M, Holloway, John W, Everson, Todd M, Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A, Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine AS, Richardson, Tom G, Magnus, Maria C, Nohr, Ellen A, Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L, Solomon, Olivia, Heimovaara, Joosje H, Jima, Dereje D, Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O, Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R, Gehring, Ulrike, Marsit, Carmen J, Beilin, Lawrence J, Vonk, Judith M, Jarvelin, Marjo-Riitta, Bergström, Anna, Örtqvist, Anne K, Ewart, Susan, Villa, Pia M, Moore, Sophie E, Willemsen, Gonneke, Standaert, Arnout RL, Håberg, Siri E, Sørensen, Thorkild IA, Taylor, Jack A, Räikkönen, Katri, Yang, Ivana V, Kechris, Katerina, Nawrot, Tim S, Silver, Matt J, Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A, Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L, Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A, Croen, Lisa A, Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hämäläinen, Esa, Routledge, Michael N, Boomsma, Dorret I, Feinberg, Andrew P, Newschaffer, Craig J, Govarts, Eva, Moisse, Matthieu, Fallin, M Daniele, Melén, Erik, and Prentice, Andrew M
Subjects: Fetus, Humans, Prenatal Exposure Delayed Effects, Birth Weight, Folic Acid, DNA, Body Mass Index, Smoking, DNA Methylation, Epigenesis, Genetic, CpG Islands, Fetal Development, Pregnancy, Genome, Human, Adolescent, Adult, Child, Infant, Newborn, Female, Male, Genome-Wide Association Study, Epigenesis, Genetic, Genome, Human, Infant, Newborn
Abstract: Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni
Published: 2019

6. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

Author: Voerman, Ellis, Santos, Susana, Golab, Bernadeta Patro, Amiano, Pilar, Ballester, Ferran, Barros, Henrique, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M, Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Iszatt, Nina, Karvonen, Anne M, Kenny, Louise C, Koletzko, Berthold, Küpers, Leanne K, Lagström, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McAuliffe, Fionnuala M, McDonald, Sheila W, Mehegan, John, Mommers, Monique, Morgen, Camilla S, Mori, Trevor A, Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nohr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte JJM, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Ronfani, Luca, Santos, Ana C, Standl, Marie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C, Trnovec, Tomas, Turner, Steve, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja GM, West, Jane, Wijga, Alet, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild IA, Lawlor, Debbie A, Gaillard, Romy, and Jaddoe, Vincent WV
Subjects: Biomedical and Clinical Sciences, Public Health, Health Sciences, Nutrition and Dietetics, Reproductive Medicine, Nutrition, Prevention, Pediatric, Clinical Research, Obesity, Oral and gastrointestinal, Stroke, Reproductive health and childbirth, Cardiovascular, Generic health relevance, Metabolic and endocrine, Cancer, Australia, Body Mass Index, Cohort Studies, Data Analysis, Europe, Female, Gestational Weight Gain, Humans, North America, Overweight, Pediatric Obesity, Pregnancy, Risk Factors, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract: BackgroundMaternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact.Methods and findingsWe conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, North America, and Australia. We assessed the individual and combined associations of maternal pre-pregnancy BMI and gestational weight gain, both in clinical categories and across their full ranges, with the risks of overweight/obesity in early (2.0-5.0 years), mid (5.0-10.0 years) and late childhood (10.0-18.0 years), using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal sociodemographic and lifestyle-related characteristics. We observed that higher maternal pre-pregnancy BMI and gestational weight gain both in clinical categories and across their full ranges were associated with higher risks of childhood overweight/obesity, with the strongest effects in late childhood (odds ratios [ORs] for overweight/obesity in early, mid, and late childhood, respectively: OR 1.66 [95% CI: 1.56, 1.78], OR 1.91 [95% CI: 1.85, 1.98], and OR 2.28 [95% CI: 2.08, 2.50] for maternal overweight; OR 2.43 [95% CI: 2.24, 2.64], OR 3.12 [95% CI: 2.98, 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1.55 [95% CI: 1.49, 1.60], and OR 1.72 [95% CI: 1.56, 1.91] for excessive gestational weight gain). The proportions of childhood overweight/obesity prevalence attributable to maternal overweight, maternal obesity, and excessive gestational weight gain ranged from 10.2% to 21.6%. Relative to the effect of maternal BMI, excessive gestational weight gain only slightly increased the risk of childhood overweight/obesity within each clinical BMI category (p-values for interactions of maternal BMI with gestational weight gain: p = 0.038, p < 0.001, and p = 0.637 in early, mid, and late childhood, respectively). Limitations of this study include the self-report of maternal BMI and gestational weight gain for some of the cohorts, and the potential of residual confounding. Also, as this study only included participants from Europe, North America, and Australia, results need to be interpreted with caution with respect to other populations.ConclusionsIn this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy.
Published: 2019

7. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author: Santos, Susana, Eekhout, Iris, Voerman, Ellis, Gaillard, Romy, Barros, Henrique, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Doyon, Myriam, Eggesbø, Merete, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Gagliardi, Luigi, Georgiu, Vagelis, Godfrey, Keith M, Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hivert, Marie-France, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Jusko, Todd A, Karvonen, Anne M, Koletzko, Berthold, Küpers, Leanne K, Lagström, Hanna, Lawlor, Debbie A, Lehmann, Irina, Lopez-Espinosa, Maria-Jose, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McDonald, Sheila W, Mommers, Monique, Morgen, Camilla S, Moschonis, George, Murínová, Ľubica, Newnham, John, Nohr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte JJM, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Roeleveld, Nel, Santa-Marina, Loreto, Santos, Ana C, Smit, Henriette A, Sørensen, Thorkild IA, Standl, Marie, Stanislawski, Maggie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C, Trnovec, Tomas, van Gelder, Marleen MHJ, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja GM, Zvinchuk, Oleksandr, van Buuren, Stef, and Jaddoe, Vincent WV
Subjects: Reproductive Medicine, Biomedical and Clinical Sciences, Health Sciences, Conditions Affecting the Embryonic and Fetal Periods, Pediatric, Nutrition, Obesity, Clinical Research, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Metabolic and endocrine, Reproductive health and childbirth, Good Health and Well Being, Adult, Body Mass Index, Europe, Female, Gestational Weight Gain, Humans, North America, Oceania, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Weight gain, Charts, References, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract: BackgroundGestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies.MethodsWe used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape.ResultsWe observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications.ConclusionsGestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice.
Published: 2018

8. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis

Author: Golab, Bernadeta Patro, Santos, Susana, Voerman, Ellis, Lawlor, Debbie A, Jaddoe, Vincent WV, Gaillard, Romy, Authors, MOCO Study Group, Barros, Henrique, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria P, Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M, Gori, Davide, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Inskip, Hazel, Ibarluzea, Jesus, Kenny, Louise C, Küpers, Leanne K, Lagström, Hanna, Lehmann, Irina, Lenters, Virissa, Llop, Sabrina Llop, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McAuliffe, Fionnuala M, McDonald, Sheila W, Mehegan, John, Mommers, Monique, Morgen, Camilla S, Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nøhr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte JJM, Pac, Agnieszka, Papadopoulou, Eleni, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Rusconi, Franca, Santos, Ana C, Smit, Henriette A, Sørensen, Thorkild IA, Standl, Marie, Stoltenberg, Camilla, Sunyer, Jordi, Taylor, Michelle, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C, Trnovec, Tomas, Turner, Steve, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja, West, Jane, Wright, John, and Zvinchuk, Oleksandr
Subjects: Nutrition, Contraception/Reproduction, Pediatric, Obesity, Prevention, Clinical Research, Cardiovascular, Perinatal Period - Conditions Originating in Perinatal Period, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Reproductive health and childbirth, Adolescent, Animals, Body Mass Index, Child, Child, Preschool, Diabetes, Gestational, Europe, Female, Humans, Hypertension, Pregnancy-Induced, Life Style, North America, Pediatric Obesity, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Risk Factors, MOCO Study Group Authors
Abstract: BackgroundGestational diabetes and gestational hypertensive disorders are associated with offspring obesity, but the role of maternal adiposity in these associations remains unclear. We aimed to investigate whether these pregnancy complications affect the odds of offspring obesity independently of maternal obesity.MethodsWe did an individual participant data (IPD) meta-analysis of mother-offspring pairs from prospective birth cohort studies that had IPD on mothers with singleton liveborn children born from 1989 onwards and had information available about maternal gestational diabetes, gestational hypertension or pre-eclampsia, and childhood body-mass index (BMI). We applied multilevel mixed-effects models to assess associations of gestational diabetes, gestational hypertension, and pre-eclampsia with BMI SD scores and the odds of overweight and obesity throughout childhood, adjusting for lifestyle characteristics (offspring's sex, maternal age, educational level, ethnicity, parity, and smoking during pregnancy). We then explored the extent to which any association was explained by maternal pre-pregnancy or early-pregnancy BMI.Findings160 757 mother-offspring pairs from 34 European or North American cohorts were analysed. Compared with uncomplicated pregnancies, gestational diabetes was associated with increased odds of overweight or obesity throughout childhood (odds ratio [OR] 1·59 [95% CI 1·36 to 1·86] for early childhood [age 2·0-4·9 years], 1·41 [1·26 to 1·57] for mid childhood [5·0-9·9 years], and 1·32 [0·97 to 1·78] for late childhood [10·0-17·9 years]); however, these associations attenuated towards the null following adjustment for maternal BMI (OR 1·35 [95% CI 1·15 to 1·58] for early childhood, 1·12 [1·00 to 1·25] for mid childhood, and 0·96 [0·71 to 1·31] for late childhood). Likewise, gestational hypertension was associated with increased odds of overweight throughout childhood (OR 1·19 [95% CI 1·01 to 1·39] for early childhood, 1·23 [1·15 to 1·32] for mid childhood, and 1·49 [1·30 to 1·70] for late childhood), but additional adjustment for maternal BMI largely explained these associations (1·01 [95% CI 0·86 to 1·19] for early childhood, 1·02 [0·95 to 1·10] for mid childhood, and 1·18 [1·03 to 1·36] for late childhood). Pre-eclampsia was associated with decreased BMI in early childhood only (difference in BMI SD score -0·05 SD score [95% CI -0·09 to -0·01]), and this association strengthened following additional adjustment for maternal BMI.InterpretationAlthough lowering maternal risk of gestational diabetes, gestational hypertension, and pre-eclampsia is important in relation to maternal and fetal pregnancy outcomes, such interventions are unlikely to have a direct impact on childhood obesity. Preventive strategies for reducing childhood obesity should focus on maternal BMI rather than on pregnancy complications.FundingEU's Horizon 2020 research and innovation programme (LifeCycle Project).
Published: 2018

9. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author: Felix, Janine F, Joubert, Bonnie R, Baccarelli, Andrea A, Sharp, Gemma C, Almqvist, Catarina, Annesi-Maesano, Isabella, Arshad, Hasan, Baïz, Nour, Bakermans-Kranenburg, Marian J, Bakulski, Kelly M, Binder, Elisabeth B, Bouchard, Luigi, Breton, Carrie V, Brunekreef, Bert, Brunst, Kelly J, Burchard, Esteban G, Bustamante, Mariona, Chatzi, Leda, Munthe-Kaas, Monica Cheng, Corpeleijn, Eva, Czamara, Darina, Dabelea, Dana, Smith, George Davey, De Boever, Patrick, Duijts, Liesbeth, Dwyer, Terence, Eng, Celeste, Eskenazi, Brenda, Everson, Todd M, Falahi, Fahimeh, Fallin, M Daniele, Farchi, Sara, Fernandez, Mariana F, Gao, Lu, Gaunt, Tom R, Ghantous, Akram, Gillman, Matthew W, Gonseth, Semira, Grote, Veit, Gruzieva, Olena, Håberg, Siri E, Herceg, Zdenko, Hivert, Marie-France, Holland, Nina, Holloway, John W, Hoyo, Cathrine, Hu, Donglei, Huang, Rae-Chi, Huen, Karen, Järvelin, Marjo-Riitta, Jima, Dereje D, Just, Allan C, Karagas, Margaret R, Karlsson, Robert, Karmaus, Wilfried, Kechris, Katerina J, Kere, Juha, Kogevinas, Manolis, Koletzko, Berthold, Koppelman, Gerard H, Küpers, Leanne K, Ladd-Acosta, Christine, Lahti, Jari, Lambrechts, Nathalie, Langie, Sabine AS, Lie, Rolv T, Liu, Andrew H, Magnus, Maria C, Magnus, Per, Maguire, Rachel L, Marsit, Carmen J, McArdle, Wendy, Melén, Erik, Melton, Phillip, Murphy, Susan K, Nawrot, Tim S, Nisticò, Lorenza, Nohr, Ellen A, Nordlund, Björn, Nystad, Wenche, Oh, Sam S, Oken, Emily, Page, Christian M, Perron, Patrice, Pershagen, Göran, Pizzi, Costanza, Plusquin, Michelle, Raikkonen, Katri, Reese, Sarah E, Reischl, Eva, Richiardi, Lorenzo, Ring, Susan, Roy, Ritu P, Rzehak, Peter, Schoeters, Greet, Schwartz, David A, Sebert, Sylvain, Snieder, Harold, Sørensen, Thorkild IA, and Starling, Anne P
Subjects: Epidemiology, Public Health, Health Sciences, Statistics, Mathematical Sciences, Child Health, Cohort Studies, DNA Methylation, Environmental Pollution, Epigenesis, Genetic, Female, Folic Acid, Humans, Infant, Newborn, Maternal Exposure, Maternal Health, Pregnancy, Prenatal Exposure Delayed Effects, Public Health and Health Services, Public health
Published: 2018

10. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Author: Sharp, Gemma C, Salas, Lucas A, Monnereau, Claire, Allard, Catherine, Yousefi, Paul, Everson, Todd M, Bohlin, Jon, Xu, Zongli, Huang, Rae-Chi, Reese, Sarah E, Xu, Cheng-Jian, Baïz, Nour, Hoyo, Cathrine, Agha, Golareh, Roy, Ritu, Holloway, John W, Ghantous, Akram, Merid, Simon K, Bakulski, Kelly M, Küpers, Leanne K, Zhang, Hongmei, Richmond, Rebecca C, Page, Christian M, Duijts, Liesbeth, Lie, Rolv T, Melton, Phillip E, Vonk, Judith M, Nohr, Ellen A, Williams-DeVane, ClarLynda, Huen, Karen, Rifas-Shiman, Sheryl L, Ruiz-Arenas, Carlos, Gonseth, Semira, Rezwan, Faisal I, Herceg, Zdenko, Ekström, Sandra, Croen, Lisa, Falahi, Fahimeh, Perron, Patrice, Karagas, Margaret R, Quraishi, Bilal M, Suderman, Matthew, Magnus, Maria C, Jaddoe, Vincent WV, Taylor, Jack A, Anderson, Denise, Zhao, Shanshan, Smit, Henriette A, Josey, Michele J, Bradman, Asa, Baccarelli, Andrea A, Bustamante, Mariona, Håberg, Siri E, Pershagen, Göran, Hertz-Picciotto, Irva, Newschaffer, Craig, Corpeleijn, Eva, Bouchard, Luigi, Lawlor, Debbie A, Maguire, Rachel L, Barcellos, Lisa F, Smith, George Davey, Eskenazi, Brenda, Karmaus, Wilfried, Marsit, Carmen J, Hivert, Marie-France, Snieder, Harold, Fallin, M Daniele, Melén, Erik, Munthe-Kaas, Monica C, Arshad, Hasan, Wiemels, Joseph L, Annesi-Maesano, Isabella, Vrijheid, Martine, Oken, Emily, Holland, Nina, Murphy, Susan K, Sørensen, Thorkild IA, Koppelman, Gerard H, Newnham, John P, Wilcox, Allen J, Nystad, Wenche, London, Stephanie J, Felix, Janine F, and Relton, Caroline L
Subjects: Biological Sciences, Genetics, Perinatal Period - Conditions Originating in Perinatal Period, Contraception/Reproduction, Pediatric, Human Genome, Obesity, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Adult, Body Mass Index, Cohort Studies, DNA Methylation, Epigenesis, Genetic, Epigenomics, Female, Humans, Infant, Newborn, Male, Maternal Inheritance, Mothers, Pregnancy, Pregnancy Outcome, Prenatal Exposure Delayed Effects, Medical and Health Sciences, Genetics & Heredity
Abstract: Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (
Published: 2017

11. Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium

Author: El Sharkawy, Mohammed, primary, Felix, Janine F., additional, Grote, Veit, additional, Voortman, Trudy, additional, Jaddoe, Vincent W. V., additional, Koletzko, Berthold, additional, and Küpers, Leanne K., additional
Published: 2024
Full Text: View/download PDF

12. Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort

Author: van Westing, Anniek C., Eckl, Marion R., Küpers, Leanne K., Pertiwi, Kamalita, Hoogeveen, Ellen K., and Geleijnse, Johanna.M.
Published: 2021
Full Text: View/download PDF

13. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author: Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Neelon, Sara E Benjamin, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, and Nystad, Wenche
Subjects: Genetics, Pediatric, Human Genome, Tobacco, Tobacco Smoke and Health, Prevention, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Respiratory, Reproductive health and childbirth, Good Health and Well Being, Asthma, Child, Child, Preschool, Chromosome Mapping, Cleft Lip, Cleft Palate, DNA Methylation, Epigenesis, Genetic, Female, Genetic Association Studies, Humans, Infant, Infant, Newborn, Pregnancy, Smoking, White People, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract: Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Published: 2016

14. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Author: Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djoussé, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Küpers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cécilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush
Published: 2021
Full Text: View/download PDF

15. Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study

Author: Monasso, Giulietta S., Küpers, Leanne K., Jaddoe, Vincent W. V., Heil, Sandra G., and Felix, Janine F.
Published: 2021
Full Text: View/download PDF

16. Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study

Author: Monasso, Giulietta S., Jaddoe, Vincent W. V., Küpers, Leanne K., and Felix, Janine F.
Published: 2021
Full Text: View/download PDF

17. Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Author: Reese, Sarah E., Xu, Cheng-Jian, den Dekker, Herman T., Lee, Mi Kyeong, Sikdar, Sinjini, Ruiz-Arenas, Carlos, Merid, Simon K., Rezwan, Faisal I., Page, Christian M., Ullemar, Vilhelmina, Melton, Phillip E., Oh, Sam S., Yang, Ivana V., Burrows, Kimberley, Söderhäll, Cilla, Jima, Dereje D., Gao, Lu, Arathimos, Ryan, Küpers, Leanne K., Wielscher, Matthias, Rzehak, Peter, Lahti, Jari, Laprise, Catherine, Madore, Anne-Marie, Ward, James, Bennett, Brian D., Wang, Tianyuan, Bell, Douglas A., Vonk, Judith M., Håberg, Siri E., Zhao, Shanshan, Karlsson, Robert, Hollams, Elysia, Hu, Donglei, Richards, Adam J., Bergström, Anna, Sharp, Gemma C., Felix, Janine F., Bustamante, Mariona, Gruzieva, Olena, Maguire, Rachel L., Gilliland, Frank, Baïz, Nour, Nohr, Ellen A., Corpeleijn, Eva, Sebert, Sylvain, Karmaus, Wilfried, Grote, Veit, Kajantie, Eero, Magnus, Maria C., Örtqvist, Anne K., Eng, Celeste, Liu, Andrew H., Kull, Inger, Jaddoe, Vincent W.V., Sunyer, Jordi, Kere, Juha, Hoyo, Cathrine, Annesi-Maesano, Isabella, Arshad, Syed Hasan, Koletzko, Berthold, Brunekreef, Bert, Binder, Elisabeth B., Räikkönen, Katri, Reischl, Eva, Holloway, John W., Jarvelin, Marjo-Riitta, Snieder, Harold, Kazmi, Nabila, Breton, Carrie V., Murphy, Susan K., Pershagen, Göran, Anto, Josep Maria, Relton, Caroline L., Schwartz, David A., Burchard, Esteban G., Huang, Rae-Chi, Nystad, Wenche, Almqvist, Catarina, Henderson, A. John, Melén, Erik, Duijts, Liesbeth, Koppelman, Gerard H., and London, Stephanie J.
Published: 2019
Full Text: View/download PDF

18. Epigenome–wide Meta–Analysis Reveals Associations between Dietary Glycemic Index and Glycemic Load and DNA methylation in Children and Adolescents with Different Body Size

Author: Ott, Raffael, primary, Stein, Robert, primary, H. Hauta–alus, Helena, primary, Ronkainen, Justiina, primary, Fernández-Barrés, Sílvia, primary, Spielau, Ulrike, primary, Kirsten, Holger, primary, Poulain, Tanja, primary, Melton, Phillip E., primary, Küpers, Leanne K., primary, Azaryah, Hatim, primary, Colombo, Marco, primary, Landgraf, Kathrin, primary, W. Tob, Elmar, primary, O’Sullivan, Therese, primary, Huang, Rae-Chi, primary, Campoy, Cristina, primary, Winkler, Christiane, primary, Vioque, Jesus, primary, Vrijheid, Martine, primary, Kiess, Wieland, primary, Körner, Antje, primary, Sebert, Sylvain, primary, Jarvelin, Marjo-Riitta, primary, Ziegler, Anette G., primary, and Hummel, Sandra, primary
Published: 2023
Full Text: View/download PDF

19. Epigenome-Wide Meta-Analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes

Author: Ott, Raffael, primary, Stein, Robert, additional, Hauta–alus, Helena H., additional, Ronkainen, Justiina, additional, Fernández–Barrés, Sílvia, additional, Spielau, Ulrike, additional, Kirsten, Holger, additional, Poulain, Tanja, additional, Melton, Phillip E., additional, Küpers, Leanne K., additional, Azaryah, Hatim, additional, Colombo, Marco, additional, Landgraf, Kathrin, additional, Tobi, Elmar W., additional, O’Sullivan, Therese, additional, Huang, Rae-Chi, additional, Campoy, Cristina, additional, Winkler, Christiane, additional, Vioque, Jesus, additional, Vrijheid, Martine, additional, Kiess, Wieland, additional, Körner, Antje, additional, Sebert, Sylvain, additional, Jarvelin, Marjo-Riitta, additional, Ziegler, Anette–G., additional, and Hummel, Sandra, additional
Published: 2023
Full Text: View/download PDF

20. Maternal Diet Quality During Pregnancy and Offspring Hepatic Fat in Early Childhood: The Healthy Start Study

Author: Cohen, Catherine C., primary, Perng, Wei, additional, Sauder, Katherine A., additional, Shapiro, Allison L.B., additional, Starling, Anne P., additional, Friedman, Chloe, additional, Felix, Janine F., additional, Küpers, Leanne K., additional, Moore, Brianna F., additional, Hébert, James R., additional, Shivappa, Nitin, additional, Scherzinger, Ann, additional, Sundaram, Shikha S., additional, Shankar, Kartik, additional, and Dabelea, Dana, additional
Published: 2023
Full Text: View/download PDF

21. Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults

Author: Pertiwi, Kamalita, Küpers, Leanne K., Geleijnse, Johanna M., Zock, Peter L., Wanders, Anne J., Kruger, Herculina S., van Zyl, Tertia, Kruger, Iolanthé M., and Smuts, Cornelius M.
Published: 2020
Full Text: View/download PDF

22. Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

Author: Magnus, Maria C., Guyatt, Anna L., Lawn, Rebecca B., Wyss, Annah B., Trajanoska, Katerina, Küpers, Leanne K., Rivadeneira, Fernando, Tobin, Martin D., London, Stephanie J., Lawlor, Debbie A., Millard, Louise A. C., and Fraser, Abigail
Published: 2020
Full Text: View/download PDF

23. Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients

Author: Pertiwi, Kamalita, Küpers, Leanne K., Wanders, Anne J., de Goede, Janette, Zock, Peter L., and Geleijnse, Johanna M.
Published: 2019
Full Text: View/download PDF

24. Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation

Author: Küpers, Leanne K., primary, Fernández-Barrés, Sílvia, additional, Mancano, Giulia, additional, Johnson, Laura, additional, Ott, Raffael, additional, Vioque, Jesus, additional, Colombo, Marco, additional, Landgraf, Kathrin, additional, Tobi, Elmar W., additional, Körner, Antje, additional, Gaillard, Romy, additional, de Vries, Jeanne H.M., additional, Jaddoe, Vincent W.V., additional, Vrijheid, Martine, additional, Sharp, Gemma C., additional, and Felix, Janine F., additional
Published: 2022
Full Text: View/download PDF

25. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author: Sonnenschein-van der Voort, Agnes M.M., Arends, Lidia R., de Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne-Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W.V., and Duijts, Liesbeth
Published: 2014
Full Text: View/download PDF

26. Parental physical activity is associated with objectively measured physical activity in young children in a sex-specific manner: the GECKO Drenthe cohort

Author: Brouwer, Silvia I., Küpers, Leanne K., Kors, Lotte, Sijtsma, Anna, Sauer, Pieter J. J., Renders, Carry M., and Corpeleijn, Eva
Published: 2018
Full Text: View/download PDF

27. Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium

Author: Küpers, Leanne K., primary, Fernández-Barrés, Sílvia, additional, Nounu, Aayah, additional, Friedman, Chloe, additional, Fore, Ruby, additional, Mancano, Giulia, additional, Dabelea, Dana, additional, Rifas-Shiman, Sheryl L., additional, Mulder, Rosa H., additional, Oken, Emily, additional, Johnson, Laura, additional, Bustamante, Mariona, additional, Jaddoe, Vincent W.V., additional, Hivert, Marie-France, additional, Starling, Anne P., additional, de Vries, Jeanne H.M., additional, Sharp, Gemma C., additional, Vrijheid, Martine, additional, and Felix, Janine F., additional
Published: 2022
Full Text: View/download PDF

28. Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Author: Tobi, Elmar W., primary, Juvinao-Quintero, Diana L., additional, Ronkainen, Justiina, additional, Ott, Raffael, additional, Alfano, Rossella, additional, Canouil, Mickaël, additional, Geurtsen, Madelon L., additional, Khamis, Amna, additional, Küpers, Leanne K., additional, Lim, Ives Y., additional, Perron, Patrice, additional, Pesce, Giancarlo, additional, Tuhkanen, Johanna, additional, Starling, Anne P., additional, Andrew, Toby, additional, Binder, Elisabeth, additional, Caiazzo, Robert, additional, Chan, Jerry K.Y., additional, Gaillard, Romy, additional, Gluckman, Peter D., additional, Keikkala, Elina, additional, Karnani, Neerja, additional, Mustaniemi, Sanna, additional, Nawrot, Tim S., additional, Pattou, François, additional, Plusquin, Michelle, additional, Raverdy, Violeta, additional, Tan, Kok Hian, additional, Tzala, Evangelia, additional, Raikkonen, Katri, additional, Winkler, Christiane, additional, Ziegler, Anette-G., additional, Annesi-Maesano, Isabella, additional, Bouchard, Luigi, additional, Chong, Yap Seng, additional, Dabelea, Dana, additional, Felix, Janine F., additional, Heude, Barbara, additional, Jaddoe, Vincent W.V., additional, Lahti, Jari, additional, Reimann, Brigitte, additional, Vääräsmäki, Marja, additional, Bonnefond, Amélie, additional, Froguel, Philippe, additional, Hummel, Sandra, additional, Kajantie, Eero, additional, Jarvelin, Marjo-Riita, additional, Steegers-Theunissen, Regine P.M., additional, Howe, Caitlin G., additional, Hivert, Marie-France, additional, and Sebert, Sylvain, additional
Published: 2022
Full Text: View/download PDF

29. Alcohol intake and long-term mortality risk after myocardial infarction in the Alpha Omega Cohort

Author: Cruijsen, Esther, primary, de Ruiter, Anne J, additional, Küpers, Leanne K, additional, Busstra, Maria C, additional, and Geleijnse, Johanna M, additional
Published: 2022
Full Text: View/download PDF

30. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Author: Solomon, Olivia, primary, Huen, Karen, additional, Yousefi, Paul, additional, Küpers, Leanne K., additional, González, Juan R., additional, Suderman, Matthew, additional, Reese, Sarah E., additional, Page, Christian M., additional, Gruzieva, Olena, additional, Rzehak, Peter, additional, Gao, Lu, additional, Bakulski, Kelly M., additional, Novoloaca, Alexei, additional, Allard, Catherine, additional, Pappa, Irene, additional, Llambrich, Maria, additional, Vives, Marta, additional, Jima, Dereje D., additional, Kvist, Tuomas, additional, Baccarelli, Andrea, additional, White, Cory, additional, Rezwan, Faisal I., additional, Sharp, Gemma C., additional, Tindula, Gwen, additional, Bergström, Anna, additional, Grote, Veit, additional, Dou, John F., additional, Isaevska, Elena, additional, Magnus, Maria C., additional, Corpeleijn, Eva, additional, Perron, Patrice, additional, Jaddoe, Vincent W.V., additional, Nohr, Ellen A., additional, Maitre, Lea, additional, Foraster, Maria, additional, Hoyo, Cathrine, additional, Håberg, Siri E., additional, Lahti, Jari, additional, DeMeo, Dawn L., additional, Zhang, Hongmei, additional, Karmaus, Wilfried, additional, Kull, Inger, additional, Koletzko, Berthold, additional, Feinberg, Jason I., additional, Gagliardi, Luigi, additional, Bouchard, Luigi, additional, Ramlau-Hansen, Cecilia Høst, additional, Tiemeier, Henning, additional, Santorelli, Gillian, additional, Maguire, Rachel L., additional, Czamara, Darina, additional, Litonjua, Augusto A., additional, Langhendries, Jean-Paul, additional, Plusquin, Michelle, additional, Lepeule, Johanna, additional, Binder, Elisabeth B., additional, Verduci, Elvira, additional, Dwyer, Terence, additional, Carracedo, Ángel, additional, Ferre, Natalia, additional, Eskenazi, Brenda, additional, Kogevinas, Manolis, additional, Nawrot, Tim S., additional, Munthe-Kaas, Monica C., additional, Herceg, Zdenko, additional, Relton, Caroline, additional, Melén, Erik, additional, Gruszfeld, Dariusz, additional, Breton, Carrie, additional, Fallin, M.D., additional, Ghantous, Akram, additional, Nystad, Wenche, additional, Heude, Barbara, additional, Snieder, Harold, additional, Hivert, Marie-France, additional, Felix, Janine F., additional, Sørensen, Thorkild I.A., additional, Bustamante, Mariona, additional, Murphy, Susan K., additional, Raikkönen, Katri, additional, Oken, Emily, additional, Holloway, John W., additional, Arshad, Syed Hasan, additional, London, Stephanie J., additional, and Holland, Nina, additional
Published: 2022
Full Text: View/download PDF

31. Dietary and Circulating Long‐Chain Omega‐3 Polyunsaturated Fatty Acids and Mortality Risk After Myocardial Infarction: A Long‐Term Follow‐Up of the Alpha Omega Cohort

Author: Pertiwi, Kamalita, primary, Küpers, Leanne K., additional, de Goede, Janette, additional, Zock, Peter L., additional, Kromhout, Daan, additional, and Geleijnse, Johanna M., additional
Published: 2021
Full Text: View/download PDF

32. Dairy consumption and mortality after myocardial infarction: a prospective analysis in the Alpha Omega Cohort

Author: Cruijsen, Esther, primary, Jacobo Cejudo, Maria G, additional, Küpers, Leanne K, additional, Busstra, Maria C, additional, and Geleijnse, Johanna M, additional
Published: 2021
Full Text: View/download PDF

33. DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Author: van Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David L., Poulton, Richie, Mill, Jonathan, Hannon, Eilis, Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine F., Bakermans-Kranenburg, Marian J., Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Gonzalez, Juan R., Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, van der Meer, Dennis, Ligthart, Lannie, Heijmans, Bastiaan T., ’t Hoen, Peter A. C., van Meurs, Joyce, Franke, Lude, Boomsma, Dorret I., Pool, René, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., ’t Hoen, Peter-Bram, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Järvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernández-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimäki, Terho, Vermeiren, Robert, Strandberg, Timo, Räikkönen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hägg, Sara, Sunyer, Jordi, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, van IJzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., McIntosh, Andrew M., Bartels, Meike, Child and Adolescent Psychiatry / Psychology, Pediatrics, Internal Medicine, Urology, Epidemiology, Orthopedics and Sports Medicine, Clinical Child and Family Studies, van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Franke, Lude, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., van Meurs, Joyce, Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., Jansen, Rick, van 't Hof, Peter, Deelen, Patrick, Nooren, Irene, 't Hoen, Peter A. C., Heijmans, Bastiaan T., Moed, Matthijs, Vermaat, Martijn, Luijk, René, Jan Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik W., 't Hoen, Peter-Bram, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., Institute for Molecular Medicine Finland, University of Helsinki, Doctoral Programme in Cognition, Learning, Instruction and Communication, Department of Psychology and Logopedics, Faculty of Medicine, Tellervo Korhonen / Principal Investigator, Genetic Epidemiology, Faculty Common Matters (Faculty of Medicine), Cognitive and Brain Aging, Helsinki Inequality Initiative (INEQ), Psychosocial factors and health, Faculty Common Matters (Faculty of Education), Medicum, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, Geriatrian yksikkö, Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Pediatric surgery, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Tampere University, Health Sciences, Department of Clinical Chemistry, Clinical Medicine, RS: MHeNs - R2 - Mental Health, and Psychiatrie & Neuropsychologie
Subjects: 0301 basic medicine, Molecular biology, ADN, Physiology, CHILDREN, 3124 Neurology and psychiatry, Epigenesis, Genetic, Epigenome, 0302 clinical medicine, Child, RISK, ASSOCIATION, Middle Aged, Justice and Strong Institutions, Aggression, Psychiatry and Mental health, Schizophrenia, TWINS, Meta-analysis, Cord blood, Child, Preschool, DNA methylation, HEALTH, medicine.symptom, SMOKING, Adult, SDG 16 - Peace, Adolescent, 515 Psychology, Longevity, Biology, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Young Adult, SDG 3 - Good Health and Well-being, Genetic variation, medicine, Genetics, Humans, ddc:610, EXPOSURE, ABUSE, Genetic association, Aged, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], SDG 16 - Peace, Justice and Strong Institutions, 3112 Neurosciences, GENOME-WIDE, DNA Methylation, Epigenètica, medicine.disease, 3141 Health care science, 030104 developmental biology, COHORT PROFILE, 1182 Biochemistry, cell and molecular biology, CpG Islands, 3111 Biomedicine, Metaanàlisi, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract: Molecular psychiatry 26(6), 2148-2162 (2021). doi:10.1038/s41380-020-00987-x, Published by Macmillan, London
Published: 2021

34. Additional file 1 of Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study

Author: Monasso, Giulietta S., Küpers, Leanne K., Jaddoe, Vincent W. V., Heil, Sandra G., and Felix, Janine F.
Abstract: Additional file 1: Figure S1. Flowchart of the study population. Figure S2. Correlation between clinical and DNA methylation gestational age.
Published: 2021
Full Text: View/download PDF

35. Maternal Adherence to the Mediterranean Diet during Pregnancy: A Review of Commonly Used a priori Indexes

Author: Eckl, Marion R., primary, Brouwer-Brolsma, Elske M., additional, and Küpers, Leanne K., additional
Published: 2021
Full Text: View/download PDF

36. Additional file 4 of Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study

Author: Magnus, Maria C., Guyatt, Anna L., Lawn, Rebecca B., Annah B. Wyss, Trajanoska, Katerina, Küpers, Leanne K., Rivadeneira, Fernando, Tobin, Martin D., London, Stephanie J., Lawlor, Debbie A., Millard, Louise A. C., and Fraser, Abigail
Abstract: Additional file 4:Figure S1. Estimates of the potential causal effect of age at menarche on bone-mineral density in UK Biobank. Figure S2. Estimates of the potential causal effect of age at menarche on adult lung function in UK Biobank.
Published: 2020
Full Text: View/download PDF

37. Additional file 1 of Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults

Author: Pertiwi, Kamalita, Küpers, Leanne K., Geleijnse, Johanna M., Zock, Peter L., Wanders, Anne J., Herculina S. Kruger, Tertia Van Zyl, Iolanthé M. Kruger, and Smuts, Cornelius M.
Abstract: Additional file 1 Table S1. Characteristics of patients in the subsample of participants with available liver enzyme values. Table S2. Baseline characteristics of participants by locality. Table S3. Spearman’s correlations of selected food groups and circulating linoleic acid. Table S4. Results from stratified analyses for associations of circulating LA with markers of liver function. Table S5. Sensitivity analyses for the cross-sectional association of dietary and circulating LA with outcomes, including only participants without high alcohol intake (n = 533). Table S6. Sensitivity analyses for the cross-sectional association of dietary and circulating LA with outcomes, including only participants without indication of alcohol abuse (n = 540). Table S7. Sensitivity analyses for the cross-sectional association of dietary and circulating LA with outcomes, including only participants with normal plasma glucose (n = 577). Figure S1. Flow chart of selection of participants. Figure S2. Circulating LA across tertiles of LA intake in total sample (A) and in subgroups of sex (B), age (C), obesity (D), fasting plasma glucose (E) and alcohol intake (F).
Published: 2020
Full Text: View/download PDF

38. Abstract P522: Alcohol Consumption and Cardiovascular Mortality After Myocardial Infarction

Author: Küpers, Leanne K, primary, de Ruiter, Anne J, additional, Busstra, Maria C, additional, and Geleijnse, Johanna M, additional
Published: 2020
Full Text: View/download PDF

39. Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort

Author: Pertiwi, Kamalita, primary, Wanders, Anne J., additional, Harbers, Marjolein C., additional, Küpers, Leanne K., additional, Soedamah-Muthu, Sabita S., additional, de Goede, Janette, additional, Zock, Peter L., additional, and Geleijnse, Johanna M., additional
Published: 2019
Full Text: View/download PDF

40. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Author: Sikdar, Sinjini, primary, Joehanes, Roby, additional, Joubert, Bonnie R, additional, Xu, Cheng-Jian, additional, Vives-Usano, Marta, additional, Rezwan, Faisal I, additional, Felix, Janine F, additional, Ward, James M, additional, Guan, Weihua, additional, Richmond, Rebecca C, additional, Brody, Jennifer A, additional, Küpers, Leanne K, additional, Baïz, Nour, additional, Håberg, Siri E, additional, Smith, Jennifer A, additional, Reese, Sarah E, additional, Aslibekyan, Stella, additional, Hoyo, Cathrine, additional, Dhingra, Radhika, additional, Markunas, Christina A, additional, Xu, Tao, additional, Reynolds, Lindsay M, additional, Just, Allan C, additional, Mandaviya, Pooja R, additional, Ghantous, Akram, additional, Bennett, Brian D, additional, Wang, Tianyuan, additional, Consortium, The BIOS, additional, Bakulski, Kelly M, additional, Melen, Erik, additional, Zhao, Shanshan, additional, Jin, Jianping, additional, Herceg, Zdenko, additional, Meurs, Joyce van, additional, Taylor, Jack A, additional, Baccarelli, Andrea A, additional, Murphy, Susan K, additional, Liu, Yongmei, additional, Munthe-Kaas, Monica Cheng, additional, Deary, Ian J, additional, Nystad, Wenche, additional, Waldenberger, Melanie, additional, Annesi-Maesano, Isabella, additional, Conneely, Karen, additional, Jaddoe, Vincent WV, additional, Arnett, Donna, additional, Snieder, Harold, additional, Kardia, Sharon LR, additional, Relton, Caroline L, additional, Ong, Ken K, additional, Ewart, Susan, additional, Moreno-Macias, Hortensia, additional, Romieu, Isabelle, additional, Sotoodehnia, Nona, additional, Fornage, Myriam, additional, Motsinger-Reif, Alison, additional, Koppelman, Gerard H, additional, Bustamante, Mariona, additional, Levy, Daniel, additional, and London, Stephanie J, additional
Published: 2019
Full Text: View/download PDF

41. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity : an individual participant data meta-analysis

Author: Patro Golab, Bernadeta, Santos, Susana, Voerman, Ellis, Lawlor, Debbie A., Jaddoe, Vincent W.V., Gaillard, Romy, Barros, Henrique, Bergström, Anna, Charles, Marie Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P., Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria P., Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M., Gori, Davide, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Inskip, Hazel, Ibarluzea, Jesus, Kenny, Louise C., Küpers, Leanne K., Lagström, Hanna, Lehmann, Irina, Lenters, Virissa, Llop, Sabrina Llop, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McAuliffe, Fionnuala M., McDonald, Sheila W., Mehegan, John, Mommers, Monique, Morgen, Camilla S., Smit, Henriette A., van Rossem, Lenie, and MOCO Study Group Authors
Subjects: Developmental and Educational Psychology, Pediatrics, Perinatology, and Child Health
Abstract: Background: Gestational diabetes and gestational hypertensive disorders are associated with offspring obesity, but the role of maternal adiposity in these associations remains unclear. We aimed to investigate whether these pregnancy complications affect the odds of offspring obesity independently of maternal obesity. Methods: We did an individual participant data (IPD) meta-analysis of mother–offspring pairs from prospective birth cohort studies that had IPD on mothers with singleton liveborn children born from 1989 onwards and had information available about maternal gestational diabetes, gestational hypertension or pre-eclampsia, and childhood body-mass index (BMI). We applied multilevel mixed-effects models to assess associations of gestational diabetes, gestational hypertension, and pre-eclampsia with BMI SD scores and the odds of overweight and obesity throughout childhood, adjusting for lifestyle characteristics (offspring's sex, maternal age, educational level, ethnicity, parity, and smoking during pregnancy). We then explored the extent to which any association was explained by maternal pre-pregnancy or early-pregnancy BMI. Findings: 160 757 mother–offspring pairs from 34 European or North American cohorts were analysed. Compared with uncomplicated pregnancies, gestational diabetes was associated with increased odds of overweight or obesity throughout childhood (odds ratio [OR] 1·59 [95% CI 1·36 to 1·86] for early childhood [age 2·0–4·9 years], 1·41 [1·26 to 1·57] for mid childhood [5·0–9·9 years], and 1·32 [0·97 to 1·78] for late childhood [10·0–17·9 years]); however, these associations attenuated towards the null following adjustment for maternal BMI (OR 1·35 [95% CI 1·15 to 1·58] for early childhood, 1·12 [1·00 to 1·25] for mid childhood, and 0·96 [0·71 to 1·31] for late childhood). Likewise, gestational hypertension was associated with increased odds of overweight throughout childhood (OR 1·19 [95% CI 1·01 to 1·39] for early childhood, 1·23 [1·15 to 1·32] for mid childhood, and 1·49 [1·30 to 1·70] for late childhood), but additional adjustment for maternal BMI largely explained these associations (1·01 [95% CI 0·86 to 1·19] for early childhood, 1·02 [0·95 to 1·10] for mid childhood, and 1·18 [1·03 to 1·36] for late childhood). Pre-eclampsia was associated with decreased BMI in early childhood only (difference in BMI SD score −0·05 SD score [95% CI −0·09 to −0·01]), and this association strengthened following additional adjustment for maternal BMI. Interpretation: Although lowering maternal risk of gestational diabetes, gestational hypertension, and pre-eclampsia is important in relation to maternal and fetal pregnancy outcomes, such interventions are unlikely to have a direct impact on childhood obesity. Preventive strategies for reducing childhood obesity should focus on maternal BMI rather than on pregnancy complications. Funding: EU's Horizon 2020 research and innovation programme (LifeCycle Project).
Published: 2018

42. Abstract P034: Circulating Odd-Chain Fatty Acids in Relation to Intake of Dairy and Fiber in Post-Myocardial Infarction Patients

Author: Pertiwi, Kamalita, primary, Küpers, Leanne K, additional, Wanders, Anne J, additional, Zock, Peter L, additional, and Geleijnse, Johanna M, additional
Published: 2019
Full Text: View/download PDF

43. EPIGENOME-WIDE ASSOCIATION STUDY META-ANALYSIS OF AGGRESSIVE BEHAVIOR

Author: van Dongen, Jenny, primary, Suderman, Matthew, additional, Sugden, Karen, additional, Chiocchetti, Andreas G., additional, Mulder, Rosa H., additional, Lahti, Jari, additional, Küpers, Leanne K., additional, Bustamante, Mariona, additional, Alemany, Silvia, additional, Bonder, Marc Jan, additional, Parmar, Priyanka, additional, Lowry, Estelle, additional, Jansen, Rick, additional, M. L. Baselmans, Bart, additional, and G. Nivard, Michel, additional
Published: 2019
Full Text: View/download PDF

44. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis

Author: Patro Golab, Bernadeta, primary, Santos, Susana, additional, Voerman, Ellis, additional, Lawlor, Debbie A, additional, Jaddoe, Vincent W V, additional, Gaillard, Romy, additional, Patro Golab, Bernadeta, additional, Barros, Henrique, additional, Bergström, Anna, additional, Charles, Marie-Aline, additional, Chatzi, Leda, additional, Chevrier, Cécile, additional, Chrousos, George P, additional, Corpeleijn, Eva, additional, Costet, Nathalie, additional, Crozier, Sarah, additional, Devereux, Graham, additional, Eggesbø, Merete, additional, Ekström, Sandra, additional, Fantini, Maria P, additional, Farchi, Sara, additional, Forastiere, Francesco, additional, Georgiu, Vagelis, additional, Godfrey, Keith M, additional, Gori, Davide, additional, Hanke, Wojciech, additional, Hertz-Picciotto, Irva, additional, Heude, Barbara, additional, Hryhorczuk, Daniel, additional, Inskip, Hazel, additional, Ibarluzea, Jesus, additional, Kenny, Louise C, additional, Küpers, Leanne K, additional, Lagström, Hanna, additional, Lehmann, Irina, additional, Lenters, Virissa, additional, Llop, Sabrina Llop, additional, Magnus, Per, additional, Majewska, Renata, additional, Mäkelä, Johanna, additional, Manios, Yannis, additional, McAuliffe, Fionnuala M, additional, McDonald, Sheila W, additional, Mehegan, John, additional, Mommers, Monique, additional, Morgen, Camilla S, additional, Moschonis, George, additional, Murray, Deirdre, additional, Ní Chaoimh, Carol, additional, Nøhr, Ellen A, additional, Nybo Andersen, Anne-Marie, additional, Oken, Emily, additional, Oostvogels, Adriëtte JJM, additional, Pac, Agnieszka, additional, Papadopoulou, Eleni, additional, Pizzi, Costanza, additional, Polanska, Kinga, additional, Porta, Daniela, additional, Richiardi, Lorenzo, additional, Rifas-Shiman, Sheryl L, additional, Rusconi, Franca, additional, Santos, Ana C, additional, Smit, Henriette A, additional, Sørensen, Thorkild IA, additional, Standl, Marie, additional, Stoltenberg, Camilla, additional, Sunyer, Jordi, additional, Taylor, Michelle, additional, Thiering, Elisabeth, additional, Thijs, Carel, additional, Torrent, Maties, additional, Tough, Suzanne C, additional, Trnovec, Tomas, additional, Turner, Steve, additional, van Rossem, Lenie, additional, von Berg, Andrea, additional, Vrijheid, Martine, additional, Vrijkotte, Tanja, additional, West, Jane, additional, Wright, John, additional, Zvinchuk, Oleksandr, additional, and Jaddoe, Vincent WV, additional
Published: 2018
Full Text: View/download PDF

45. Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort.

Author: Pertiwi, Kamalita, Wanders, Anne J., Harbers, Marjolein C., Küpers, Leanne K., Soedamah-Muthu, Sabita S., de Goede, Janette, Zock, Peter L., and Geleijnse, Johanna M.
Subjects: TYPE 2 diabetes, LINOLEIC acid, MYOCARDIAL infarction, TRANS fatty acids, MYOCARDIAL infarction complications, RESEARCH, FAT content of food, RESEARCH methodology, DIET, EVALUATION research, MEDICAL cooperation, SURVEYS, COMPARATIVE studies, QUESTIONNAIRES, LONGITUDINAL method
Abstract: Objective: To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post-myocardial infarction (MI) patients.Research Design and Methods: We included 3,257 patients aged 60-80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002-2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and trans fatty acids (TFA).Results: Mean ± SD circulating and dietary LA was 50.1 ± 4.9% and 5.9 ± 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman r = 0.13, P < 0.001). During a median follow-up of 41 months, 171 patients developed type 2 diabetes. Plasma LA was inversely associated with type 2 diabetes risk (quintile [Q]5 vs. Q1: 0.44 [0.26, 0.75]; per 5%: 0.73 [0.62, 0.86]). Substitution of dietary LA for SFA+TFA showed no association with type 2 diabetes risk (Q5 vs. Q1: 0.78 [0.36, 1.72]; per 5% energy: 1.18 [0.59, 2.35]). Adjustment for markers of de novo lipogenesis attenuated plasma LA associations.Conclusions: In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients. [ABSTRACT FROM AUTHOR]
Published: 2020
Full Text: View/download PDF

46. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author: Felix, Janine F, primary, Joubert, Bonnie R, additional, Baccarelli, Andrea A, additional, Sharp, Gemma C, additional, Almqvist, Catarina, additional, Annesi-Maesano, Isabella, additional, Arshad, Hasan, additional, Baïz, Nour, additional, Bakermans-Kranenburg, Marian J, additional, Bakulski, Kelly M, additional, Binder, Elisabeth B, additional, Bouchard, Luigi, additional, Breton, Carrie V, additional, Brunekreef, Bert, additional, Brunst, Kelly J, additional, Burchard, Esteban G, additional, Bustamante, Mariona, additional, Chatzi, Leda, additional, Cheng Munthe-Kaas, Monica, additional, Corpeleijn, Eva, additional, Czamara, Darina, additional, Dabelea, Dana, additional, Davey Smith, George, additional, De Boever, Patrick, additional, Duijts, Liesbeth, additional, Dwyer, Terence, additional, Eng, Celeste, additional, Eskenazi, Brenda, additional, Everson, Todd M, additional, Falahi, Fahimeh, additional, Fallin, M Daniele, additional, Farchi, Sara, additional, Fernandez, Mariana F, additional, Gao, Lu, additional, Gaunt, Tom R, additional, Ghantous, Akram, additional, Gillman, Matthew W, additional, Gonseth, Semira, additional, Grote, Veit, additional, Gruzieva, Olena, additional, Håberg, Siri E, additional, Herceg, Zdenko, additional, Hivert, Marie-France, additional, Holland, Nina, additional, Holloway, John W, additional, Hoyo, Cathrine, additional, Hu, Donglei, additional, Huang, Rae-Chi, additional, Huen, Karen, additional, Järvelin, Marjo-Riitta, additional, Jima, Dereje D, additional, Just, Allan C, additional, Karagas, Margaret R, additional, Karlsson, Robert, additional, Karmaus, Wilfried, additional, Kechris, Katerina J, additional, Kere, Juha, additional, Kogevinas, Manolis, additional, Koletzko, Berthold, additional, Koppelman, Gerard H, additional, Küpers, Leanne K, additional, Ladd-Acosta, Christine, additional, Lahti, Jari, additional, Lambrechts, Nathalie, additional, Langie, Sabine AS, additional, Lie, Rolv T, additional, Liu, Andrew H, additional, Magnus, Maria C, additional, Magnus, Per, additional, Maguire, Rachel L, additional, Marsit, Carmen J, additional, McArdle, Wendy, additional, Melén, Erik, additional, Melton, Phillip, additional, Murphy, Susan K, additional, Nawrot, Tim S, additional, Nisticò, Lorenza, additional, Nohr, Ellen A, additional, Nordlund, Björn, additional, Nystad, Wenche, additional, Oh, Sam S, additional, Oken, Emily, additional, Page, Christian M, additional, Perron, Patrice, additional, Pershagen, Göran, additional, Pizzi, Costanza, additional, Plusquin, Michelle, additional, Raikkonen, Katri, additional, Reese, Sarah E, additional, Reischl, Eva, additional, Richiardi, Lorenzo, additional, Ring, Susan, additional, Roy, Ritu P, additional, Rzehak, Peter, additional, Schoeters, Greet, additional, Schwartz, David A, additional, Sebert, Sylvain, additional, Snieder, Harold, additional, Sørensen, Thorkild IA, additional, Starling, Anne P, additional, Sunyer, Jordi, additional, Taylor, Jack A, additional, Tiemeier, Henning, additional, Ullemar, Vilhelmina, additional, Vafeiadi, Marina, additional, Van Ijzendoorn, Marinus H, additional, Vonk, Judith M, additional, Vriens, Annette, additional, Vrijheid, Martine, additional, Wang, Pei, additional, Wiemels, Joseph L, additional, Wilcox, Allen J, additional, Wright, Rosalind J, additional, Xu, Cheng-Jian, additional, Xu, Zongli, additional, Yang, Ivana V, additional, Yousefi, Paul, additional, Zhang, Hongmei, additional, Zhang, Weiming, additional, Zhao, Shanshan, additional, Agha, Golareh, additional, Relton, Caroline L, additional, Jaddoe, Vincent WV, additional, and London, Stephanie J, additional
Published: 2017
Full Text: View/download PDF

47. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the Pregnancy and Childhood Epigenetics (PACE) consortium

Author: Sharp, Gemma C, primary, Salas, Lucas A, additional, Monnereau, Claire, additional, Allard, Catherine, additional, Yousefi, Paul, additional, Everson, Todd M, additional, Bohlin, Jon, additional, Xu, Zongli, additional, Huang, Rae-Chi, additional, Reese, Sarah E, additional, Xu, Cheng-Jian, additional, Baïz, Nour, additional, Hoyo, Cathrine, additional, Agha, Golareh, additional, Roy, Ritu, additional, Holloway, John W, additional, Ghantous, Akram, additional, Merid, Simon Kebede, additional, Bakulski, Kelly M, additional, Küpers, Leanne K, additional, Zhang, Hongmei, additional, Richmond, Rebecca C, additional, Page, Christian M, additional, Duijts, Liesbeth, additional, Lie, Rolv T, additional, Melton, Phillip E, additional, Vonk, Judith M, additional, Nohr, Ellen A, additional, Williams-DeVane, CharLynda, additional, Huen, Karen, additional, Rifas-Shiman, Sheryl L, additional, Ruiz-Arenas, Carlos, additional, Gonseth, Semira, additional, Rezwan, Faisal I, additional, Herceg, Zdenko, additional, Ekström, Sandra, additional, Croen, Lisa, additional, Falahi, Fahimeh, additional, Perron, Patrice, additional, Karagas, Margaret R, additional, Quraishi, Bilal Mohammed, additional, Suderman, Matthew, additional, Magnus, Maria C, additional, Jaddoe, Vincent WV, additional, Taylor, Jack A, additional, Anderson, Denise, additional, Zhao, Shanshan, additional, Smit, Henriette A, additional, Josey, Michele J, additional, Bradman, Asa, additional, Baccarelli, Andrea A, additional, Bustamante, Mariona, additional, Håberg, Siri E, additional, Pershagen, Göran, additional, Hertz-Picciotto, Irva, additional, Newschaffer, Craig, additional, Corpeleijn, Eva, additional, Bouchard, Luigi, additional, Lawlor, Debbie A, additional, Maguire, Rachel L, additional, Barcellos, Lisa F, additional, Smith, George Davey, additional, Eskenazi, Brenda, additional, Karmaus, Wilfried, additional, Marsit, Carmen J, additional, Hivert, Marie-France, additional, Snieder, Harold, additional, Fallin, M Daniele, additional, Melén, Erik, additional, Munthe-Kaas, Monica C, additional, Arshad, Hasan, additional, Wiemels, Joseph L, additional, Annesi-Maesano, Isabella, additional, Vrijheid, Martine, additional, Oken, Emily, additional, Holland, Nina, additional, Murphy, Susan K, additional, Sørensen, Thorkild IA, additional, Koppelman, Gerard H, additional, Newnham, John P, additional, Wilcox, Allen J, additional, Nystad, Wenche, additional, London, Stephanie J, additional, Felix, Janine F, additional, and Relton, Caroline L, additional
Published: 2017
Full Text: View/download PDF

48. QCEWAS: automated quality control of results of epigenome-wide association studies

Author: Van der Most, Peter J, primary, Küpers, Leanne K, additional, Snieder, Harold, additional, and Nolte, Ilja, additional
Published: 2017
Full Text: View/download PDF

49. DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

Author: Küpers, Leanne K, Xu, Xiaojing, Jankipersadsing, Soesma A, Vaez, Ahmad, la Bastide-van Gemert, Sacha, Scholtens, Salome, Nolte, Ilja M, Richmond, Rebecca C, Relton, Caroline L, Felix, Janine F, Duijts, Liesbeth, van Meurs, Joyce B, Tiemeier, Henning, Jaddoe, Vincent W, Wang, Xiaoling, Corpeleijn, Eva, Snieder, Harold, Public Health, Erasmus MC other, Pediatrics, Internal Medicine, Epidemiology, Life Course Epidemiology (LCE), Reproductive Origins of Adult Health and Disease (ROAHD), and Lifestyle Medicine (LM)
Subjects: Adult, Male, TOBACCO-SMOKE, PRESCHOOL-CHILDREN, AUTOIMMUNITY, Epigenesis, Genetic, Cohort Studies, Pregnancy, Risk Factors, GECKO, Birth Weight, Humans, COHORT, CORD BLOOD, EXPOSURE, GENE-EXPRESSION, RISK, Early Life Environment, Generation R, IDENTIFICATION, Epigenetic epidemiology, Smoking, DOHaD, Infant, Newborn, ASSOCIATION, DNA Methylation, ALSPAC, Fetal Blood, epigenome-wide association study, DNA-Binding Proteins, fetal programming, Maternal Exposure, Prenatal Exposure Delayed Effects, Linear Models, Female, Genome-Wide Association Study, Transcription Factors
Abstract: Background: We examined whether the effect of maternal smoking during pregnancy on birthweight of the offspring was mediated by smoking-induced changes to DNA methylation in cord blood. Methods: First, we used cord blood of 129 Dutch children exposed to maternal smoking vs 126 unexposed to maternal and paternal smoking (53% male) participating in the GECKO Drenthe birth cohort. DNA methylation was measured using the Illumina HumanMethylation450 Beadchip. We performed an epigenome-wide association study for the association between maternal smoking and methylation followed by a mediation analysis of the top signals [false-discovery rate (FDR)
Published: 2015

50. Prevalence and distribution of (micro)albuminuria in toddlers

Author: Gracchi, Valentina, primary, van den Belt, Sophie M., additional, Küpers, Leanne K., additional, Corpeleijn, Eva, additional, de Zeeuw, Dick, additional, and Heerspink, Hiddo J.L., additional
Published: 2015
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

216 results on '"Küpers, Leanne K."'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources