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3. Comparison of Cryoballoon vs. Pulsed Field Ablation in Patients with Symptomatic Paroxysmal Atrial Fibrillation (SINGLE SHOT CHAMPION): Study protocol for a randomized controlled trial

Author

Maurhofer, Jens, Kueffer, Thomas, Knecht, Sven, Thalmann, Gregor, Badertscher, Patrick, Kozhuharov, Nikola, Krisai, Philipp, Jufer, Corinne, Iqbal, Salik ur Rehman, Heg, Dik, Servatius, Helge, Tanner, Hildegard, Kühne, Michael, Roten, Laurent, Sticherling, Christian, and Reichlin, Tobias

Published
2024
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4. Safety and Effectiveness of Pulsed Field Ablation for Atrial Fibrillation in Patients With Heart Failure

Author

Turagam, Mohit K., Neuzil, Petr, Schmidt, Boris, Reichlin, Tobias, Neven, Kars, Metzner, Andreas, Hansen, Jim, Blaauw, Yuri, Maury, Philippe, Arentz, Thomas, Sommer, Philipp, Anic, Ante, Anselme, Frederic, Boveda, Serge, Deneke, Tom, Willems, Stephan, van der Voort, Pepijn, Tilz, Roland, Funasako, Moritoshi, Scherr, Daniel, Wakili, Reza, Steven, Daniel, Kautzner, Josef, Vijgen, Johan, Jais, Pierre, Petru, Jan, Chun, Julian, Roten, Laurent, Füting, Anna, Lemoine, Marc D., Ruwald, Martin, Mulder, Bart A., Rollin, Anne, Lehrmann, Heiko, Fink, Thomas, Jurisic, Zrinka, Chaumont, Corentin, Adelino, Raquel, Nentwich, Karin, Gunawardene, Melanie, Ouss, Alexandre, Heeger, Christian-Hendrik, Manninger, Martin, Bohnen, Jan-Eric, Sultan, Arian, Peichl, Petr, Koopman, Pieter, Derval, Nicolas, Kueffer, Thomas, Reinsch, Nico, and Reddy, Vivek Y.

Published
2024
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7. Impact of Left Atrial Posterior Wall Ablation During Pulsed-Field Ablation for Persistent Atrial Fibrillation

Author

Turagam, Mohit K., Neuzil, Petr, Schmidt, Boris, Reichlin, Tobias, Neven, Kars, Metzner, Andreas, Hansen, Jim, Blaauw, Yuri, Maury, Philippe, Arentz, Thomas, Sommer, Philipp, Anic, Ante, Anselme, Frederic, Boveda, Serge, Deneke, Tom, Willems, Stephan, van der Voort, Pepijn, Tilz, Roland, Funasako, Moritoshi, Scherr, Daniel, Wakili, Reza, Steven, Daniel, Kautzner, Josef, Vijgen, Johan, Jais, Pierre, Petru, Jan, Chun, Julian, Roten, Laurent, Füting, Anna, Lemoine, Marc D., Ruwald, Martin, Mulder, Bart A., Rollin, Anne, Lehrmann, Heiko, Fink, Thomas, Jurisic, Zrinka, Chaumont, Corentin, Adelino, Raquel, Nentwich, Karin, Gunawardene, Melanie, Ouss, Alexandre, Heeger, Christian-Hendrik, Manninger, Martin, Bohnen, Jan-Eric, Sultan, Arian, Peichl, Petr, Koopman, Pieter, Derval, Nicolas, Kueffer, Thomas, Reinsch, Nico, and Reddy, Vivek Y.

Published
2024
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8. Durability of Pulmonary Vein Isolation Using Pulsed-Field Ablation: Results From the Multicenter EU-PORIA Registry

Author

Kueffer, Thomas, Bordignon, Stefano, Neven, Kars, Blaauw, Yuri, Hansen, Jim, Adelino, Raquel, Ouss, Alexandre, Füting, Anna, Roten, Laurent, Mulder, Bart A., Ruwald, Martin H., Mené, Roberto, van der Voort, Pepijn, Reinsch, Nico, Boveda, Serge, Albrecht, Elizabeth M., Schneider, Christopher W., Chun, K.R. Julian, Schmidt, Boris, and Reichlin, Tobias

Published
2024
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9. Comparison of the PolarX and the Arctic Front cryoballoon for pulmonary vein isolation in patients with symptomatic paroxysmal atrial fibrillation (COMPARE CRYO) – Study protocol for a randomized controlled trial

Author

Maurhofer, Jens, Kueffer, Thomas, Knecht, Sven, Madaffari, Antonio, Badertscher, Patrick, Seiler, Jens, Krisai, Philipp, Jufer, Corinne, Asatryan, Babken, Heg, Dik, Servatius, Helge, Tanner, Hildegard, Kühne, Michael, Roten, Laurent, Sticherling, Christian, and Reichlin, Tobias

Published
2023
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11. Dexmedetomidine versus propofol for operator-directed nurse-administered procedural sedation during catheter ablation of atrial fibrillation: A randomized controlled study

Author

Servatius, Helge, Küffer, Thomas, Baldinger, Samuel H., Asatryan, Babken, Seiler, Jens, Tanner, Hildegard, Novak, Jan, Lam, Anna, Noti, Fabian, Haeberlin, Andreas, Madaffari, Antonio, Sweda, Romy, Mühl, Aline, Branca, Mattia, Dütschler, Sophie, Erdoes, Gabor, Stüber, Frank, Theiler, Lorenz, Reichlin, Tobias, and Roten, Laurent

Published
2022
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12. Impact of atrial fibrillation phenotype and left atrial volume on outcome after pulmonary vein isolation

Author

Chollet, Laurève, primary, Iqbal, Salik ur Rehman, additional, Wittmer, Severin, additional, Thalmann, Gregor, additional, Madaffari, Antonio, additional, Kozhuharov, Nikola, additional, Galuszka, Oskar, additional, Küffer, Thomas, additional, Gräni, Christoph, additional, Brugger, Nicolas, additional, Servatius, Helge, additional, Noti, Fabian, additional, Haeberlin, Andreas, additional, Roten, Laurent, additional, Tanner, Hildegard, additional, and Reichlin, Tobias, additional

Published
2024
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14. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Author

Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian-Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S. S. G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.

Published
2024
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16. Atrial substrate characterization based on bipolar voltage electrograms acquired with multipolar, focal and mini-electrode catheters

Author

Knecht, Sven, primary, Schlageter, Vincent, additional, Badertscher, Patrick, additional, Krisai, Philipp, additional, Jousset, Florian, additional, Küffer, Thomas, additional, Madaffari, Antonio, additional, Schaer, Beat, additional, Osswald, Stefan, additional, Sticherling, Christian, additional, and Kühne, Michael, additional

Published
2023
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18. Validation of a clinical model for predicting left versus right ventricular outflow tract origin of idiopathic ventricular arrhythmias.

Author

Bourquin, Luc, Küffer, Thomas, Asatryan, Babken, Badertscher, Patrick, Baldinger, Samuel H., Knecht, Sven, Seiler, Jens, Spies, Florian, Servatius, Helge, Kühne, Michael, Noti, Fabian, Osswald, Stefan, Haeberlin, Andreas, Tanner, Hildegard, Roten, Laurent, Reichlin, Tobias, and Sticherling, Christian

Subjects
*ARRHYTHMIA treatment, *HYPERTENSION, *AGE distribution, *RETROSPECTIVE studies, *CATHETER ablation, *VENTRICULAR tachycardia, *RISK assessment, *SEX distribution, *VENTRICULAR arrhythmia, *THEORY, *DESCRIPTIVE statistics, *ELECTROCARDIOGRAPHY, *ARRHYTHMIA, *PREDICTION models, *SENSITIVITY & specificity (Statistics), *LONGITUDINAL method, *ALGORITHMS, *DISEASE risk factors
Abstract

Background: Prediction of the chamber of origin in patients with outflow tract ventricular arrhythmias (OTVA) remains challenging. A clinical risk score based on age, sex and presence of hypertension was associated with a left ventricular outflow tract (LVOT) origin. We aimed to validate this clinical score to predict an LVOT origin in patients with OTVA. Methods: In a two‐center observational cohort study, unselected patients undergoing catheter ablation (CA) for OTVA were enrolled. All procedures were performed using an electroanatomical mapping system. Successful ablation was defined as a ≥80% reduction of the initial overall PVC burden after 3 months of follow‐up. Patients with unsuccessful ablation were excluded from this analysis. Results: We included 187 consecutive patients with successful CA of idiopathic OTVA. Mean age was 52 ± 15 years, 102 patients (55%) were female, and 74 (40%) suffered from hypertension. A LVOT origin was found in 64 patients (34%). A score incorporating age, sex and presence of hypertension reached 73% sensitivity and 67% specificity for a low (0–1) and high (2–3) score, to predict an LVOT origin. The combination of one ECG algorithm (V2S/V3R‐index) with the clinical score resulted in a sensitivity and specificity of 81% and 70% for PVCs with R/S transition at V3. Conclusion: The published clinical score yielded a lower sensitivity and specificity in our cohort. However, for PVCs with R/S transition at V3, the combination with an existing ECG algorithm can improve the predictability of LVOT origin. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Left atrial substrate characterization based on bipolar voltage electrograms acquired with multipolar, focal and mini-electrode catheters– the CHAZE-Substrate study

Author

Knecht, Sven, primary, Schlageter, Vincent, additional, Badertscher, Patrick, additional, Krisai, Philipp, additional, Jousset, Florian, additional, Spies, Florian, additional, Küffer, Thomas, additional, Madaffari, Antonio, additional, Schaer, Beat, additional, Osswald, Stefan, additional, Sticherling, Christian, additional, and Kühne, Michael, additional

Published
2023
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20. Pulsed-Field-Ablation for the Treatment of Atrial Fibrillation in Patients with Congenital Anomalies of Cardiac Veins

Author

Castiglione, Alessandro, Küffer, Thomas, Gräni, Christoph, Servatius, Helge, Reichlin, Tobias, and Roten, Laurent

Subjects
610 Medicine & health
Abstract

INTRODUCTION Anomalous cardiac veins are not rare and pulmonary vein (PV) isolation for atrial fibrillation (AF) treatment should include these veins. Pulsed-field ablation (PFA) is a novel technology for AF ablation with excellent efficacy and safety profile. In this case series, we describe our first experience of isolation of anomalous cardiac veins using PFA in patients with AF. METHODS We report a series of patients with congenital anomalies of the cardiac veins and AF, treated with PFA. All patients underwent cardiac computed tomography for procedural planning. RESULTS We included five patients (4 males). Anomalous cardiac veins included a connection of a left common ostium to the coronary sinus, a partial and a complete drainage of the right superior PV into the superior vena cava (SVC) with and without additional atrial septal defect, a persistent left SVC and an anomalous posterior PV. All anomalous PVs were isolated using PFA. No phrenic nerve palsy or other complications occurred. PFA of an abnormal right superior PV draining into the distal SVC was possible without affecting the sinus node. After a median of four months, four patients were free of recurrence. One patient had recurrent AF and perimitral reentry tachycardia, probably facilitated by PFA in the mitral isthmus region during isolation of an anomalous connection of the left common ostium to the coronary sinus. CONCLUSIONS Using systematic pre-procedural imaging and 3D-electroanatomic mapping, the currently available PFA system seems well suited, efficient and versatile for the treatment of AF in patients with anomalous cardiac veins. This article is protected by copyright. All rights reserved.

Published
2023
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21. Pulsed-field ablation for the treatment of left atrial reentry tachycardia

Author

Küffer, Thomas, primary, Seiler, Jens, additional, Madaffari, Antonio, additional, Mühl, Aline, additional, Asatryan, Babken, additional, Stettler, Robin, additional, Haeberlin, Andreas, additional, Noti, Fabian, additional, Servatius, Helge, additional, Tanner, Hildegard, additional, Baldinger, Samuel, additional, Reichlin, Tobias, additional, and Roten, Laurent, additional

Published
2022
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23. Efficacy and safety of a novel cryoballoon ablation system: multicentre comparison of 1-year outcome

Author

Knecht, Sven, primary, Sticherling, Christian, additional, Roten, Laurent, additional, Badertscher, Patrick, additional, Krisai, Philipp, additional, Chollet, Laurève, additional, Küffer, Thomas, additional, Spies, Florian, additional, Völlmin, Gian, additional, Madaffari, Antonio, additional, Mühl, Aline, additional, Baldinger, Samuel H, additional, Servatius, Helge, additional, Tanner, Hildegard, additional, Osswald, Stefan, additional, Reichlin, Tobias, additional, and Kühne, Michael, additional

Published
2022
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24. LB-469809-04 SAFETY AND EFFECTIVENESS OF PULSED FIELD ABLATION FOR ATRIAL FIBRILLATION IN PATIENTS WITH HEART FAILURE: A MANIFEST-PF REGISTRY SUB-ANALYSIS

Author

Turagam, Mohit K., Neuzil, Petr, Schmidt, Boris, Reichlin, Tobias, Neven, Kars, Metzner, Andreas, Hansen, Jim, Blaauw, Yuri, Maury, Philippe, Arentz, Thomas, Sommer, Philipp, Anic, Ante, Anselme, Frederic, Boveda, Serge, Deneke, Tom, Willems, Stephan, van der Voort, Pepijn, Tilz, Roland, Funasako, Moritoshi, Scherr, Daniel, Wakili, Reza, Steven, Daniel, Kautzner, Josef, Vijgen, Johan, Jais, Pierre, Petru, Jan, Chun, Julian, Roten, Laurent, Füting, Anna, Lemoine, Marc D., Ruwald, Martin, Mulder, Bart A., Rollin, Anne, Lehrmann, Heiko, Fink, Thomas, Jurisic, Zrinka, Chaumont, Corentin, Adelino, Raquel, Nentwich, Karin, Gunawardene, Melanie, Ouss, Alexandre, Heeger, Christian-Hendrik, Manninger, Martin, Bohnen, Jan-Eric, Sultan, Arian, Peichl, Petr, Koopman, Pieter, Derval, Nicolas, Kueffer, Thomas, Reinsch, Nico, and Reddy, Vivek Y.

Published
2024
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25. PO-03-108 PULSED FIELD ABLATION AS A FIRST-LINE THERAPY FOR PAROXYSMAL ATRIAL FIBRILLATION – SUB-STUDY OF THE EU-PORIA REGISTRY

Author

Neven, Kars, Schmidt, Boris, Bordignon, Stefano, Reichlin, Tobias, Blaauw, Yuri, Hansen, Jim, Adelino, Raquel, Ouss, Alexandre, Füting, Anna, Roten, Laurent, Mulder, Bart A., Ruwald, Martin H., Menè, Roberto, Van Der Voort, Pepijn H., Reinsch, Nico, Kueffer, Thomas, BOVEDA, SERGE, Schneider, Christopher, Albrecht, Elizabeth, and Chun, Julian K.

Published
2024
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26. PO-03-107 PULSED FIELD ABLATION AS A FIRST-LINE THERAPY FOR PERSISTENT ATRIAL FIBRILLATION – SUB-STUDY OF THE EU-PORIA REGISTRY

Author

Schmidt, Boris, Bordignon, Stefano, Neven, Kars, Reichlin, Tobias, Blaauw, Yuri, Hansen, Jim, Adelino, Raquel, Ouss, Alexandre, Füting, Anna, Roten, Laurent, Mulder, Bart A., Ruwald, Martin H., Menè, Roberto, Van Der Voort, Pepijn H., Reinsch, Nico, Kueffer, Thomas, BOVEDA, SERGE, Schneider, Christopher, Albrecht, Elizabeth, and Chun, Julian K.

Published
2024
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28. MP-483498-004 IMPACT OF THE NUMBER OF EARLY RECURRENCE EPISODES DURING THE BLANKING PERIOD IN PATIENTS AFTER CRYOBALLOON ABLATION – INSIGHTS FROM THE COMPARE-CRYO STUDY USING CONTINUOUS RHYTHM MONITORING

Author

Iqbal, Salik ur, Kueffer, Thomas, Knecht, Sven, Madaffari, Antonio, Badertscher, Patrick, Maurhofer, Jens, Krisai, Philip, Jufer, Corinne, Thalmann, Gregor, Heg, Dik, Servatius, Helge, Tanner, Hildegard, Kuhne, Michael, Roten, Laurent, Sticherling, Christian, and Reichlin, Tobias

Published
2024
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29. Technical and procedural comparison of two different cryoballoon ablation systems in patients with atrial fibrillation

Author

Knecht, Sven, primary, Sticherling, Christian, additional, Roten, Laurent, additional, Badertscher, Patrick, additional, Chollet, Laurève, additional, Küffer, Thomas, additional, Spies, Florian, additional, Madaffari, Antonio, additional, Mühl, Aline, additional, Baldinger, Samuel H., additional, Servatius, Helge, additional, Osswald, Stefan, additional, Reichlin, Tobias, additional, and Kühne, Michael, additional

Published
2021
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31. Efficacy and safety of ethanol infusion into the vein of Marshall for mitral isthmus ablation

Author

Lam, Anna, primary, Küffer, Thomas, additional, Hunziker, Lukas, additional, Nozica, Nikolas, additional, Asatryan, Babken, additional, Franzeck, Florian, additional, Madaffari, Antonio, additional, Haeberlin, Andreas, additional, Mühl, Aline, additional, Servatius, Helge, additional, Seiler, Jens, additional, Noti, Fabian, additional, Baldinger, Samuel H., additional, Tanner, Hildegard, additional, Windecker, Stephan, additional, Reichlin, Tobias, additional, and Roten, Laurent, additional

Published
2021
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32. Pre‐procedural arrhythmia burden and the outcome of catheter ablation of idiopathic premature ventricular complexes

Author

Asatryan, Babken, primary, Seiler, Jens, additional, Bourquin, Luc, additional, Knecht, Sven, additional, Servatius, Helge, additional, Madaffari, Antonio, additional, Baldinger, Samuel H., additional, Badertscher, Patrick, additional, Küffer, Thomas, additional, Spies, Florian, additional, Tanner, Hildegard, additional, Kühne, Michael, additional, Osswald, Stefan, additional, Roten, Laurent, additional, Sticherling, Christian, additional, and Reichlin, Tobias, additional

Published
2021
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33. LB-456091-3 EUROPEAN REAL WORLD OUTCOMES WITH PULSED FIELD ABLATION IN PATIENTS WITH SYMPTOMATIC ATRIAL FIBRILLATION - LESSONS FROM THE MULTICENTER EU-PORIA REGISTRY

Author

Schmidt, Boris, Bordignon, Stefano, Neven, Kars, Reichlin, Tobias, Blaauw, Yuri, Hansen, Jim, Adelino, Raquel, Ouss, Alexandre, Füting, Anna, Roten, Laurent, Mulder, Bart A., Ruwald, Martin H., Menè, Roberto, Van Der Voort, Pepijn H., Reinsch, Nico, Kueffer, Thomas, Boveda, Serge, and Chun, Julian K.

Published
2023
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35. Efficacy and safety of a novel cryoballoon ablation system: multicentre comparison of 1-year outcome.

Author

Knecht S, Sticherling C, Roten L, Badertscher P, Krisai P, Chollet L, Küffer T, Spies F, Völlmin G, Madaffari A, Mühl A, Baldinger SH, Servatius H, Tanner H, Osswald S, Reichlin T, and Kühne M

Subjects
Humans, Middle Aged, Aged, Treatment Outcome, Cryosurgery adverse effects, Cryosurgery methods, Pulmonary Veins surgery, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Catheter Ablation methods
Abstract

Aims: The aim of the study was to compare the 1-year efficacy and safety of a novel cryoballoon (NCB) ablation system (POLARx; Boston Scientific) for pulmonary vein isolation (PVI) compared with the standard cryoballoon (SCB) system (Arctic Front, Medtronic)., Methods and Results: Consecutive patients with atrial fibrillation (AF) undergoing PVI using the NCB and the SCB at two centres were included. We report 1-year efficacy after 12 months, short-term safety and hospitalizations within the blanking period, and predictors for AF recurrence. In case of repeat procedures, pulmonary vein (PV) reconnection patterns were characterized. Eighty patients (age 66 ± 10 years, ejection fraction 57 ± 10%, left atrial volume index 39 ± 13 mL/m2, paroxysmal AF in 64%) were studied. After a single procedure and a follow-up of 12 months, 68% in the NCB group and 70% in the SCB group showed no recurrence of AF/atrial tachycardias (P = 0.422). One patient in the NCB group suffered a periprocedural stroke with full recovery. There were no differences regarding hospitalizations during follow-up between the groups. PV reconnection observed during 12 repeat procedures (4 NCB, 8 SCB) pattern was comparable between the groups with more reconnections in the right-sided compared with the left-sided PVs., Conclusion: In this multicentre study comparing two currently available cryoballoon ablation systems for PVI, no differences were observed in the efficacy and safety during a follow-up of 12 months., Competing Interests: Conflict of interest: T.R. has received speaker/consulting honoraria or travel support from Abbott/SJM, Astra Zeneca, Brahms, Bayer, Biosense-Webster, Biotronik, Boston-Scientific, Daiichi Sankyo, Medtronic, Pfizer-BMS, and Roche, all for work outside the submitted study. He has received research grants from the Goldschmidt-Jacobson Foundation, the Swiss National Science Foundation, the Swiss Heart Foundation, the European Union (Eurostars 9799–ALVALE), the Professor Max Cloëtta Foundation, the Cardiovascular Research Foundation Basel, the University of Basel, and the University Hospital Basel. He has received support for his institution’s fellowship program from Abbott/SJM, Biosense-Webster, Biotronik, Boston-Scientific, and Medtronic for work outside the submitted study. S.H.B. has received research support from Biosense-Webster and travel grants from Biosense Webster and Boston-Scientific all for work outside the submitted study. L.R. has received speaker/consulting honoraria from Abbott/SJM and Medtronic. M.K. reports grants from the Swiss National Science Foundation, Swiss Heart Foundation, Bayer, Pfizer BMS, Boston Scientific, personal fees from Bayer, Böhringer Ingelheim, Pfizer BMS, Daiichi Sankyo, Medtronic, Biotronik, Boston Scientific, Johnson & Johnson all outside the submitted work. C.S. reports grants from the European Union’s FP7 program, Biosense-Webster and lecture and consulting fees from Abbott, Medtronic, Biosense-Webster, Boston Scientific, Microport, and Biotronik. S.K. reports grant from the Stiftung Kardiovaskuläre Forschung. The rest of the authors report no conflicts of interest. No commercial entities participated in this study., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2022
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