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Fecal specimens obtained from 505 rats, 317 mice, 128 rabbits and 52 guinea pigs were examined for helminth infections. In general, 38.02% of rats and 83.59% of mice were infected with one or more helminth species. The percentage of Syphacia muris and Syphacia obvelata were 32.48% and 12.67%, respectively, in rats, and the percentage of Aspiculuris tetraptera, S. obvelata and Hymenolepis nana were 79.18%, 10.72% and 15.45%, respectively, in mice. Passalurus ambiguus was found only in one rabbit (0.78 %). No helminth infections were detected in guinea pigs.

Purpose: To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of topotecan-related myeloid suppression., Methods: No medication was given to 21 rats in group 1; 1.5 mg/m2/day topotecan was administered intraperitoneally for five days every three weeks to 21 rats in group II; a single dose of 5 microg/kg filgrastim was injected intraperitoneally 24 hours before the intraperitoneal administration of the same dose of topotecan to 21 rats in group III. After completion of six cycles of chemotherapy. the rats were decapitated and blood samples were immediately collected into citrated tubes for complete blood counts., Results: White blood cell and lymphocyte counts in the control and the filgrastim + topotecan groups were similar (p > 0.05) and significantly higher than the counts in the topotecan group (p < 0.05). There was no difference in means of neutrophil, monocyte, eosinophil, basophil and erythrocyte counts among the groups (p > 0.05)., Conclusion: Filgrastim administration prior to chemotherapy seems to be beneficial and further investigations are needed.