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1. Using graph neural networks to reconstruct charged pion showers in the CMS High Granularity Calorimeter

Author

Aamir, M., Adamov, G., Adams, T., Adloff, C., Afanasiev, S., Agrawal, C., Ahmad, A., Ahmed, H. A., Akbar, S., Akchurin, N., Akgul, B., Akgun, B., Akpinar, R. O., Aktas, E., Kadhim, A. Al, Alexakhin, V., Alimena, J., Alison, J., Alpana, A., Alshehri, W., Dominguez, P. Alvarez, Alyari, M., Amendola, C., Amir, R. B., Andersen, S. B., Andreev, Y., Antoszczuk, P. D., Aras, U., Ardila, L., Aspell, P., Avila, M., Awad, I., Aydilek, O., Azimi, Z., Pretel, A. Aznar, Bach, O. A., Bainbridge, R., Bakshi, A., Bam, B., Banerjee, S., Barney, D., Bayraktar, O., Beaudette, F., Beaujean, F., Becheva, E., Behera, P. K., Belloni, A., Bergauer, T., Besancon, M., Bylund, O. Bessidskaia, Bhatt, L., Bhattacharya, S., Bhowmil, D., Blekman, F., Blinov, P., Bloch, P., Bodek, A., Boger, a., Bonnemaison, A., Bouyjou, F., Brennan, L., Brondolin, E., Brusamolino, A., Bubanja, I., Perraguin, A. Buchot, Bunin, P., Misura, A. Burazin, Butler-nalin, A., Cakir, A., Callier, S., Campbell, S., Candemir, Y. B., Canderan, K., Cankocak, K., Cappati, A., Caregari, S., Carron, S., Carty, C., Cauchois, A., Ceard, L., Cerci, S., Chang, P. J., Chatterjee, R. M., Chatterjee, S., Chattopadhyay, P., Chatzistavrou, T., Chaudhary, M. S., Chen, J. A., Chen, J., Chen, Y., Cheng, K., Cheung, H., Chhikara, J., Chiron, A., Chiusi, M., Chokheli, D., Chudasama, R., Clement, E., Mendez, S. Coco, Coko, D., Coskun, K., Couderc, F., Crossman, B., Cui, Z., Cuisset, T., Cummings, G., Curtis, E. M., D'Alfonso, M., Döhler-Ball, J., Dadazhanova, O., Damgov, J., Das, I., Gupta, S. Das, Dauncey, P., Mendes, A. David Tinoco, Davies, G., Davignon, O., de Barbaro, P., De La Taille, C., De Silva, M., De Wit, A., Debbins, P., Defranchis, M. M., Delagnes, E., Devouge, P., Di Guglielmo, G., Diehl, L., Dilsiz, K., Dincer, G. G., Dittmann, J., Dragicevic, M., Du, D., Dubinchik, B., Dugad, S., Dulucq, F., Dumanoglu, I., Duran, B., Dutta, S., Dutta, V., Dychkant, A., Dünser, M., Edberg, T., Ehle, I. T., Berni, A. El, Elias, F., Eno, S. C., Erdogan, E. N., Erkmen, B., Ershov, Y., Ertorer, E. Y., Extier, S., Eychenne, L., Fedar, Y. E., Fedi, G., De Almeida, J. P. Figueiredo De Sá Sousa, Alves, B. A. Fontana Santos, Frahm, E., Francis, K., Freeman, J., French, T., Gaede, F., Gandhi, P. K., Ganjour, S., Garcia-Bellido, A., Gastaldi, F., Gazi, L., Gecse, Z., Gerwig, H., Gevin, O., Ghosh, S., Gill, K., Gingu, C., Gleyzer, S., Godinovic, N., Goettlicher, P., Goff, R., Gok, M., Golunov, A., Gonultas, B., Martínez, J. D. González, Gorbounov, N., Gouskos, L., Gray, A., Gray, L., Grieco, C., Groenroos, S., Groner, D., Gruber, A., Grummer, A., Grönroos, S., Guerrero, D., Guilloux, F., Guler, Y., Gungordu, A. D., Guo, J., Guo, K., Guler, E. Gurpinar, Gutti, H. K., Guvenli, A. A., Gülmez, E., Hacisahinoglu, B., Halkin, Y., Machado, G. Hamilton Ilha, Hare, H. S., Hatakeyama, K., Heering, A. H., Hegde, V., Heintz, U., Hinton, N., Hinzmann, A., Hirschauer, J., Hitlin, D., Hoff, J., Hos, İ., Hou, B., Hou, X., Howard, A., Howe, C., Hsieh, H., Hsu, T., Hua, H., Hummer, F., Imran, M., Incandela, J., Iren, E., Isildak, B., Jackson, P. S., Jackson, W. J., Jain, S., Jana, P., Jaroslavceva, J., Jena, S., Jige, A., Jordano, P. P., Joshi, U., Kaadze, K., Kachanov, V., Kafizov, A., Kalipoliti, L., Tharayil, A. Kallil, Kaluzinska, O., Kamble, S., Kaminskiy, A., Kanemura, M., Kanso, H., Kao, Y., Kapic, A., Kapsiak, C., Karjavine, V., Karmakar, S., Karneyeu, A., Kaya, M., Topaksu, A. Kayis, Kaynak, B., Kazhykarim, Y., Khan, F. A., Khudiakov, A., Kieseler, J., Kim, R. S., Klijnsma, T., Kloiber, E. G., Klute, M., Kocak, Z., Kodali, K. R., Koetz, K., Kolberg, T., Kolcu, O. B., Komaragiri, J. R., Komm, M., Kopsalis, I., Krause, H. A., Krawczyk, M. A., Vinayakam, T. R. Krishnaswamy, Kristiansen, K., Kristic, A., Krohn, M., Kronheim, B., Krüger, K., Kudtarkar, C., Kulis, S., Kumar, M., Kumar, N., Kumar, S., Verma, R. Kumar, Kunori, S., Kunts, A., Kuo, C., Kurenkov, A., Kuryatkov, V., Kyre, S., Ladenson, J., Lamichhane, K., Landsberg, G., Langford, J., Laudrain, A., Laughlin, R., Lawhorn, J., Dortz, O. Le, Lee, S. W., Lektauers, A., Lelas, D., Leon, M., Levchuk, L., Li, A. J., Li, J., Li, Y., Liang, Z., Liao, H., Lin, K., Lin, W., Lin, Z., Lincoln, D., Linssen, L., Litomin, A., Liu, G., Liu, Y., Lobanov, A., Lohezic, V., Loiseau, T., Lu, C., Lu, R., Lu, S. Y., Lukens, P., Mackenzie, M., Magnan, A., Magniette, F., Mahjoub, A., Mahon, D., Majumder, G., Makarenko, V., Malakhov, A., Malgeri, L., Mallios, S., Mandloi, C., Mankel, A., Mannelli, M., Mans, J., Mantilla, C., Martinez, G., Massa, C., Masterson, P., Matthewman, M., Matveev, V., Mayekar, S., Mazlov, I., Mehta, A., Mestvirishvili, A., Miao, Y., Milella, G., Mirza, I. R., Mitra, P., Moccia, S., Mohanty, G. B., Monti, F., Moortgat, F., Murthy, S., Music, J., Musienko, Y., Nabili, S., Nelson, J. W., Nema, A., Neutelings, I., Niedziela, J., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Obraztsov, S., Ochando, C., Ogul, H., Olsson, J., Onel, Y., Ozkorucuklu, S., Paganis, E., Palit, P., Pan, R., Pandey, S., Pantaleo, F., Papageorgakis, C., Paramesvaran, S., Paranjpe, M. M., Parolia, S., Parsons, A. G., Parygin, P., Pastika, J., Paulini, M., Paus, C., Castillo, K. Peñaló, Pedro, K., Pekic, V., Peltola, T., Peng, B., Perego, A., Perini, D., Petrilli, A., Pham, H., Podem, S. K., Popov, V., Portales, L., Potok, O., Pradeep, P. B., Pramanik, R., Prosper, H., Prvan, M., Qasim, S. R., Qu, H., Quast, T., Trivio, A. Quiroga, Rabour, L., Raicevic, N., Rao, M. A., Rapacz, K., Redjeb, W., Reinecke, M., Revering, M., Roberts, A., Rohlf, J., Rosado, P., Rose, A., Rothman, S., Rout, P. K., Rovere, M., Roy, A., Rubinov, P., Rumerio, P., Rusack, R., Rygaard, L., Ryjov, V., Sadivnycha, S., Sahin, M. Ö., Sakarya, U., Salerno, R., Saradhy, R., Saraf, M., Sarbandi, K., Sarkisla, M. A., Satyshev, I., Saud, N., Sauvan, J., Schindler, G., Schmidt, A., Schmidt, I., Schmitt, M. H., Sculac, A., Sculac, T., Sedelnikov, A., Seez, C., Sefkow, F., Selivanova, D., Selvaggi, M., Sergeychik, V., Sert, H., Shahid, M., Sharma, P., Sharma, R., Sharma, S., Shelake, M., Shenai, A., Shih, C. W., Shinde, R., Shmygol, D., Shukla, R., Sicking, E., Silva, P., Simsek, C., Simsek, E., Sirasva, B. K., Sirois, Y., Song, S., Song, Y., Soudais, G., Sriram, S., Jacques, R. R. St, Leiton, A. G. Stahl, Steen, A., Stein, J., Strait, J., Strobbe, N., Su, X., Sukhov, E., Suleiman, A., Cerci, D. Sunar, Suryadevara, P., Swain, K., Syal, C., Tali, B., Tanay, K., Tang, W., Tanvir, A., Tao, J., Tarabini, A., Tatli, T., Taylor, R., Taysi, Z. C., Teafoe, G., Tee, C. Z., Terrill, W., Thienpont, D., Thomas, P. E., Thomas, R., Titov, M., Todd, C., Todd, E., Toms, M., Tosun, A., Troska, J., Tsai, L., Tsamalaidze, Z., Tsionou, D., Tsipolitis, G., Tsirigoti, M., Tu, R., Polat, S. N. Tural, Undleeb, S., Usai, E., Uslan, E., Ustinov, V., Uzunian, A., Vernazza, E., Viahin, O., Viazlo, O., Vichoudis, P., Vijay, A., Virdee, T., Voirin, E., Vojinovic, M., Vámi, T. Á., Wade, A., Walter, D., Wang, C., Wang, F., Wang, J., Wang, K., Wang, X., Wang, Y., Wang, Z., Wanlin, E., Wayne, M., Wetzel, J., Whitbeck, A., Wickwire, R., Wilmot, D., Wilson, J., Wu, H., Xiao, M., Yang, J., Yazici, B., Ye, Y., Yerli, B., Yetkin, T., Yi, R., Yohay, R., Yu, T., Yuan, C., Yuan, X., Yuksel, O., YushmanoV, I., Yusuff, I., Zabi, A., Zareckis, D., Zehetner, P., Zghiche, A., Zhang, C., Zhang, D., Zhang, H., Zhang, J., Zhang, Z., Zhao, X., Zhong, J., Zhou, Y., and Zorbilmez, Ç.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Physics - Data Analysis, Statistics and Probability
Abstract

A novel method to reconstruct the energy of hadronic showers in the CMS High Granularity Calorimeter (HGCAL) is presented. The HGCAL is a sampling calorimeter with very fine transverse and longitudinal granularity. The active media are silicon sensors and scintillator tiles readout by SiPMs and the absorbers are a combination of lead and Cu/CuW in the electromagnetic section, and steel in the hadronic section. The shower reconstruction method is based on graph neural networks and it makes use of a dynamic reduction network architecture. It is shown that the algorithm is able to capture and mitigate the main effects that normally hinder the reconstruction of hadronic showers using classical reconstruction methods, by compensating for fluctuations in the multiplicity, energy, and spatial distributions of the shower's constituents. The performance of the algorithm is evaluated using test beam data collected in 2018 prototype of the CMS HGCAL accompanied by a section of the CALICE AHCAL prototype. The capability of the method to mitigate the impact of energy leakage from the calorimeter is also demonstrated.

Published
2024
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2. Performance of the CMS High Granularity Calorimeter prototype to charged pion beams of 20$-$300 GeV/c

Author

Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Alhusseini, M., Alison, J., de Almeida, J. P. Figueiredo de sa Sousa, de Almeida, P. G. Dias, Alpana, A., Alyari, M., Andreev, I., Aras, U., Aspell, P., Atakisi, I. O., Bach, O., Baden, A., Bakas, G., Bakshi, A., Banerjee, S., DeBarbaro, P., Bargassa, P., Barney, D., Beaudette, F., Beaujean, F., Becheva, E., Becker, A., Behera, P., Belloni, A., Bergauer, T., Berni, M. El, Besancon, M., Bhattacharya, S., Bhowmik, D., Bilki, B., Bilokin, S., Blazey, G. C., Blekman, F., Bloch, P., Bodek, A., Bonanomi, M., Bonis, J., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Bower, N., Braga, D., Brennan, L., Brianne, E., Brondolin, E., Bryant, P., Buhmann, E., Buhmann, P., Butler-Nalin, A., Bychkova, O., Callier, S., Calvet, D., Canderan, K., Cankocak, K., Cao, X., Cappati, A., Caraway, B., Caregari, S., Carty, C., Cauchois, A., Ceard, L., Cerci, D. S., Cerci, S., Cerminara, G., Chadeeva, M., Charitonidis, N., Chatterjee, R., Chen, J. A., Chen, Y. M., Cheng, H. J., Cheng, K. Y., Cheung, H., Chokheli, D., Cipriani, M., Čoko, D., Couderc, F., Cuba, E., Danilov, M., Dannheim, D., Daoud, W., Das, I., Dauncey, P., Davies, G., Davignon, O., Day, E., Debbins, P., Defranchis, M. M., Delagnes, E., Demiragli, Z., Demirbas, U., Derylo, G., Diaz, D., Diehl, L., Dinaucourt, P., Dincer, G. G., Dittmann, J., Dragicevic, M., Dugad, S., Dulucq, F., Dumanoglu, I., Dünser, M., Dutta, S., Dutta, V., Edberg, T. K., Elias, F., Emberger, L., Eno, S. C., Ershov, Yu., Extier, S., Fahim, F., Fallon, C., Fard, K. Sarbandi, Fedi, G., Ferragina, L., Forthomme, L., Frahm, E., Franzoni, G., Freeman, J., French, T., Gadow, K., Gandhi, P., Ganjour, S., Gao, X., Garcia, M. T. Ramos, Garcia-Bellido, A., Garutti, E., Gastaldi, F., Gastler, D., Gecse, Z., Germer, A., Gerwig, H., Gevin, O., Ghosh, S., Gilbert, A., Gilbert, W., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonultas, B., Gorbounov, N., Göttlicher, P., Gouskos, L., Graf, C., Gray, A. B., Grieco, C., Gr\"önroos, S., Gu, Y., Guilloux, F., Guler, E. Gurpinar, Guler, Y., Gülmez, E., Guo, J., Gutti, H., Hakimi, A., Hammer, M., Hartbrich, O., Hassanshahi, H. M., Hatakeyama, K., Hazen, E., Heering, A., Hegde, V., Heintz, U., Heuchel, D., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. S., Hou, X., Hua, H., Huck, S., Hussain, A., Incandela, J., Irles, A., Irshad, A., Isik, C., Jain, S., Jaroslavceva, J., Jheng, H. R., Joshi, U., Kaadze, K., Kachanov, V., Kalipoliti, L., Kaminskiy, A., Kanuganti, A. R., Kao, Y. W., Kapoor, A., Kara, O., Karneyeu, A., Kałuzińska, O., Kaya, M., Kaya, O., Kazhykharim, Y., Khan, F. A., Khukhunaishvili, A., Kieseler, J., Kilpatrick, M., Kim, S., Koetz, K., Kolberg, T., Komm, M., Köseyan, O. K., Kraus, V., Krawczyk, M., Kristiansen, K., Kristić, A., Krohn, M., Kronheim, B., Krüger, K., Kulis, S., Kumar, M., Kunori, S., Kuo, C. M., Kuryatkov, V., Kvasnicka, J., Kyre, S., Lai, Y., Lamichhane, K., Landsberg, G., Lange, C., Langford, J., Laurien, S., Lee, M. Y., Lee, S. W., Leiton, A. G. Stahl, Levin, A., Li, A., Li, J. H., Li, Y. Y., Liang, Z., Liao, H., Lin, Z., Lincoln, D., Linssen, L., Lipton, R., Liu, G., Liu, Y., Lobanov, A., Lohezic, V., Lomidze, D., Lu, R. S., Lu, S., Lupi, M., Lysova, I., Magnan, A. -M., Magniette, F., Mahjoub, A., Martens, S., Matysek, M., Meier, B., Malakhov, A., Mallios, S., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Martinez, G., Masterson, P., Matthewman, M., Mayekar, S. N., David, A., Coco, S., Meng, B., Menkel, A ., Mestvirishvili, A., Milella, G., Mirza, I., Moccia, S., Mohanty, G. B., Monti, F., Moortgat, F. W., Morrissey, I., Motta, J., Murthy, S., Musić, J., Musienko, Y., Nabili, S., Nguyen, M., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Nursanto, M. Wulansatiti, Ochando, C., Odell, N., Okawa, H., Onel, Y., Ortez, W., Ozegović, J., Ozkorucuklu, S., Paganis, E., Palmer, C. A., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Paranjpe, M., Parshook, J., Pastika, N., Paulini, M., Peitzmann, T., Peltola, T., Peng, N., Perraguin, A. Buchot, Petiot, P., Pierre-Emile, T., Pinto, M. Vicente Barreto, Popova, E., Pöschl, R., Prosper, H., Prvan, M., Puljak, I., Qasim, S. R., Qu, H., Quast, T., Quinn, R., Quinnan, M., Rane, A., Rao, K. K., Rapacz, K., Raux, L., Redjeb, W., Reinecke, M., Revering, M., Richard, F., Roberts, A., Sanchez, A. M., Rohlf, J., Rolph, J., Romanteau, T., Rosado, M., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Rusinov, V., Ryjov, V., Sahin, O. M., Salerno, R., Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Schuwalow, S., Scott, E., Seez, C., Sefkow, F., Selivanova, D., Sharma, S., Shelake, M., Shenai, A., Shukla, R., Sicking, E., De, M., Silva, P., Simkina, P., Simon, F., Simsek, A. E., Sirois, Y., Smirnov, V., Sobering, T. J., Spencer, E., Srimanobhas, N., Steen, A., Strait, J., Strobbe, N., Su, X. F., Sudo, Y., Suarez, C. Mantilla, Sukhov, E., Sulak, L., Sun, L., Suryadevara, P., Syal, C., de La Taille, C., Tali, B., Tan, C. L., Tao, J., Tarabini, A., Tatli, T., Thaus, R., Taylor, R. D., Tekten, S., Thiebault, A., Thienpont, D., Tiley, C., Tiras, E., Titov, M., Tlisov, D., Tok, U. G., Kayis, A., Troska, J., Tsai, L. S., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Undleeb, S., Urbanski, D., Uslan, E., Ustinov, V., Uzunian, A., Varela, J., Velasco, M., Vernazza, E., Viazlo, O., Vichoudis, P., Virdee, T., Voirin, E., Vojinovi\c, M., Vojinovic, M., Wade, A., Wang, C., Wang, C. C., Wang, D., Wang, F., Wang, X., Wang, Z., Wayne, M., Webb, S. N., Whitbeck, A., Wickwire, R., Wilson, J. S., Wu, H. Y., Wu, L., Xiao, M., Yang, J., Yeh, C. H, Yohay, R., Yu, D., Yu, S. S., Yuan, C., Miao, Y., Yumiceva, F., Yusuff, I., Zabi, A., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zehetner, P., Zerwas, D., Zhang, H., Zhang, J., Zhang, Y., Zhang, Z., and Zhao, X.

Subjects
Physics - Instrumentation and Detectors
Abstract

The upgrade of the CMS experiment for the high luminosity operation of the LHC comprises the replacement of the current endcap calorimeter by a high granularity sampling calorimeter (HGCAL). The electromagnetic section of the HGCAL is based on silicon sensors interspersed between lead and copper (or copper tungsten) absorbers. The hadronic section uses layers of stainless steel as an absorbing medium and silicon sensors as an active medium in the regions of high radiation exposure, and scintillator tiles directly readout by silicon photomultipliers in the remaining regions. As part of the development of the detector and its readout electronic components, a section of a silicon-based HGCAL prototype detector along with a section of the CALICE AHCAL prototype was exposed to muons, electrons and charged pions in beam test experiments at the H2 beamline at the CERN SPS in October 2018. The AHCAL uses the same technology as foreseen for the HGCAL but with much finer longitudinal segmentation. The performance of the calorimeters in terms of energy response and resolution, longitudinal and transverse shower profiles is studied using negatively charged pions, and is compared to GEANT4 predictions. This is the first report summarizing results of hadronic showers measured by the HGCAL prototype using beam test data., Comment: Accepted for publication by JINST

Published
2022

3. Response of a CMS HGCAL silicon-pad electromagnetic calorimeter prototype to 20-300 GeV positrons

Author

Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Khan, F. Alam, Alhusseini, M., Alison, J., Alpana, A., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Aspell, P., Atakisi, I. O., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bannerjee, S., Bargassa, P., Barney, D., Beaudette, F., Beaujean, F., Becheva, E., Becker, A., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bilki, B., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Bower, N., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Perraguin, A. Buchot, Bueghly, J., Burkle, B., Butler-Nalin, A., Bychkova, O., Callier, S., Calvet, D., Cao, X., Cappati, A., Caraway, B., Caregari, S., Cauchois, A., Ceard, L., Cekmecelioglu, Y. C., Cerci, S., Cerminara, G., Chadeeva, M., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, H. J., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Danilov, M., Dannheim, D., Daoud, W., Dauncey, P., David, A., Davies, G., Davignon, O., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Defranchis, M. M., Delagnes, E., Berrio, J. M. Deltoro, Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dulucq, F., Dumanoglu, I., Dutta, V., Dutta, S., Dünser, M., Eckdahl, J., Edberg, T. K., Berni, M. El, Elias, F., Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Fedi, G., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Gandhi, P., Ganjour, S., Gao, X., Garcia-Bellido, A., Gastaldi, F., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Ghosh, S., Gilbert, A., Gilbert, W., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gray, A. B., Gu, Y., Guilloux, F., Guler, Y., Gülmez, E., Guo, J., Guler, E. Gurpinar, Hammer, M., Hassanshahi, H. M., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. -S., Hou, X., Hua, H., Incandela, J., Irshad, A., Isik, C., Jain, S., Jheng, H. R., Joshi, U., Kachanov, V., Kalinin, A., Kalipoliti, L., Kaminskiy, A., Kapoor, A., Kara, O., Karneyeu, A., Kaya, M., Kaya, O., Topaksu, A. Kayis, Khukhunaishvili, A., Kiesler, J., Kilpatrick, M., Kim, S., Koetz, K., Kolberg, T., Köseyan, O. K., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Lai, Y., Lamichhane, K., Landsberg, G., Lange, C., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. H., Li, Y. y., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. -S., Lupi, M., Lysova, I., Magnan, A. -M., Magniette, F., Mahjoub, A., Maier, A. A., Malakhov, A., Mallios, S., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Martinez, G., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Mohanty, G. B., Monti, F., Morrissey, I., Murthy, S., Musić, J., Musienko, Y., Nabili, S., Nagar, A., Nguyen, M., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Okawa, H., Onel, Y., Ortez, W., Ozegović, J., Ozkorucuklu, S., Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pierre-Emile, T., Pitters, F., Popova, E., Prosper, H., Prvan, M., Puljak, I., Qu, H., Quast, T., Quinn, R., Quinnan, M., Garcia, M. T. Ramos, Rao, K. K., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Roberts, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Rusinov, V., Ryjov, V., Sahin, O. M., Salerno, R., Rodriguez, A. M. Sanchez, Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Silva, P., Simsek, A. E., Sirois, Y., Smirnov, V., Sozbilir, U., Spencer, E., Steen, A., Strait, J., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Cerci, D. Sunar, Syal, C., Tali, B., Tan, C. L., Tao, J., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Tiras, E., Titov, M., Tlisov, D., Tok, U. G., Troska, J., Tsai, L. -S., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., Van de Klundert, M., Varela, J., Velasco, M., Viazlo, O., Pinto, M. Vicente Barreto, Virdee, P. Vichoudis T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Vojinovic, M., Wade, A., Wang, C., Wang, F., Wang, X., Wang, Z., Wayne, M., Webb, S. N., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Winter, D., Wu, H. y., Wu, L., Nursanto, M. Wulansatiti, Yeh, C. H, Yohay, R., Yu, D., Yu, G. B., Yu, S. S., Yuan, C., Yumiceva, F., Yusuff, I., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zghiche, A., Zhang, H., Zhang, J., Zhang, Y., and Zhang, Z.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The Compact Muon Solenoid Collaboration is designing a new high-granularity endcap calorimeter, HGCAL, to be installed later this decade. As part of this development work, a prototype system was built, with an electromagnetic section consisting of 14 double-sided structures, providing 28 sampling layers. Each sampling layer has an hexagonal module, where a multipad large-area silicon sensor is glued between an electronics circuit board and a metal baseplate. The sensor pads of approximately 1 cm$^2$ are wire-bonded to the circuit board and are readout by custom integrated circuits. The prototype was extensively tested with beams at CERN's Super Proton Synchrotron in 2018. Based on the data collected with beams of positrons, with energies ranging from 20 to 300 GeV, measurements of the energy resolution and linearity, the position and angular resolutions, and the shower shapes are presented and compared to a detailed Geant4 simulation.

Published
2021
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4. Construction and commissioning of CMS CE prototype silicon modules

Author

Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Alhusseini, M., Alison, J., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Andrews, M., Aspell, P., Atakisi, I. A., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bargassa, P., Barney, D., Becheva, E., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Bueghly, J., Bilki, B., Burkle, B., Butler-Nalin, A., Callier, S., Calvet, D., Cao, X., Caraway, B., Caregari, S., Ceard, L., Cekmecelioglu, Y. C., Cerminara, G., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Dumanoglu, I., Dannheim, D., Dauncey, P., David, A., Davies, G., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Delagnes, E., Deltoro, J. M., Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dutta, V., Dutta, S., Eckdahl, J., Edberg, T. K., Berni, M. El, Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Guler, E. Gurpinar, Guler, Y., Gagnan, M., Gandhi, P., Ganjour, S., Garcia-Bellido, A., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Gilbert, W., Gilbert, A., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gu, Y., Guilloux, F., Gülmez, E., Hammer, M., Harilal, A., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinger, V., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. S., Isik, C., Incandela, J., Jain, S., Jheng, H. R., Joshi, U., Kara, O., Kachanov, V., Kalinin, A., Kameshwar, R., Kaminskiy, A., Karneyeu, A., Kaya, O., Kaya, M., Khukhunaishvili, A., Kim, S., Koetz, K., Kolberg, T., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Köseyan, O. K., Lai, Y., Lamichhane, K., Landsberg, G., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. -H., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. S., Lysova, I., Magnan, A. M., Magniette, F., Maier, A. A., Malakhov, A., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Morrissey, I., Mudholkar, T., Musić, J., Musienko, I., Nabili, S., Nagar, A., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Onel, Y., Ortez, W., Ozegović, J., Rodriguez, L. Pacheco, Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pitters, F., Prosper, H., Prvan, M., Puljak, I., Quast, T., Quinn, R., Quinnan, M., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Rodriguez, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Simsek, A. E., Sozbilir, U., Sahin, O. M., Sanchez, A., Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Sirois, Y., Smirnov, V., Spencer, E., Steen, A., Strait, J., Strebler, T., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Sun, M., Syal, C., Tali, B., Tok, U. G., Topaksu, A. Kayis, Tan, C. L., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Pierre-Emile, T., Tiras, E., Titov, M., Tlisov, D., Troska, J., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., van de Klundert, M., Varela, J., Velasco, M., Pinto, M. Vicente Barreto, da Silva, P. M., Virdee, T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Wang, Z., Wang, X., Wang, F., Wayne, M., Webb, S. N., Weinberg, M., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Wu, H. Y., Wu, L., Yeh, C. H, Yohay, R., Yu, G. B., Yu, S. S., Yu, D., Yumiceva, F., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zhang, H., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

As part of its HL-LHC upgrade program, the CMS Collaboration is developing a High Granularity Calorimeter (CE) to replace the existing endcap calorimeters. The CE is a sampling calorimeter with unprecedented transverse and longitudinal readout for both electromagnetic (CE-E) and hadronic (CE-H) compartments. The calorimeter will be built with $\sim$30,000 hexagonal silicon modules. Prototype modules have been constructed with 6-inch hexagonal silicon sensors with cell areas of 1.1~$cm^2$, and the SKIROC2-CMS readout ASIC. Beam tests of different sampling configurations were conducted with the prototype modules at DESY and CERN in 2017 and 2018. This paper describes the construction and commissioning of the CE calorimeter prototype, the silicon modules used in the construction, their basic performance, and the methods used for their calibration., Comment: 35 pages, submitted to JINST

Published
2020

5. The DAQ system of the 12,000 Channel CMS High Granularity Calorimeter Prototype

Author

Acar, B., Adamov, G., Adloff, C., Afanasiev, S., Akchurin, N., Akgün, B., Alhusseini, M., Alison, J., Altopp, G., Alyari, M., An, S., Anagul, S., Andreev, I., Andrews, M., Aspell, P., Atakisi, I. A., Bach, O., Baden, A., Bakas, G., Bakshi, A., Bargassa, P., Barney, D., Becheva, E., Behera, P., Belloni, A., Bergauer, T., Besancon, M., Bhattacharya, S., Bhowmik, D., Bloch, P., Bodek, A., Bonanomi, M., Bonnemaison, A., Bonomally, S., Borg, J., Bouyjou, F., Braga, D., Brashear, J., Brondolin, E., Bryant, P., Bueghly, J., Bilki, B., Burkle, B., Butler-Nalin, A., Callier, S., Calvet, D., Cao, X., Caraway, B., Caregari, S., Ceard, L., Cekmecelioglu, Y. C., Cerminara, G., Charitonidis, N., Chatterjee, R., Chen, Y. M., Chen, Z., Cheng, K. y., Chernichenko, S., Cheung, H., Chien, C. H., Choudhury, S., Čoko, D., Collura, G., Couderc, F., Dumanoglu, I., Dannheim, D., Dauncey, P., David, A., Davies, G., Day, E., DeBarbaro, P., De Guio, F., de La Taille, C., De Silva, M., Debbins, P., Delagnes, E., Deltoro, J. M., Derylo, G., de Almeida, P. G. Dias, Diaz, D., Dinaucourt, P., Dittmann, J., Dragicevic, M., Dugad, S., Dutta, V., Dutta, S., Eckdahl, J., Edberg, T. K., Berni, M. El, Eno, S. C., Ershov, Yu., Everaerts, P., Extier, S., Fahim, F., Fallon, C., Alves, B. A. Fontana Santos, Frahm, E., Franzoni, G., Freeman, J., French, T., Guler, E. Gurpinar, Guler, Y., Gagnan, M., Gandhi, P., Ganjour, S., Garcia-Bellido, A., Gecse, Z., Geerebaert, Y., Gerwig, H., Gevin, O., Gilbert, W., Gilbert, A., Gill, K., Gingu, C., Gninenko, S., Golunov, A., Golutvin, I., Gonzalez, T., Gorbounov, N., Gouskos, L., Gu, Y., Guilloux, F., Gülmez, E., Hammer, M., Harilal, A., Hatakeyama, K., Heering, A., Hegde, V., Heintz, U., Hinger, V., Hinton, N., Hirschauer, J., Hoff, J., Hou, W. S., Isik, C., Incandela, J., Jain, S., Jheng, H. R., Joshi, U., Kara, O., Kachanov, V., Kalinin, A., Kameshwar, R., Kaminskiy, A., Karneyeu, A., Kaya, O., Kaya, M., Khukhunaishvili, A., Kim, S., Koetz, K., Kolberg, T., Kristić, A., Krohn, M., Krüger, K., Kulagin, N., Kulis, S., Kunori, S., Kuo, C. M., Kuryatkov, V., Kyre, S., Köseyan, O. K., Lai, Y., Lamichhane, K., Landsberg, G., Langford, J., Lee, M. Y., Levin, A., Li, A., Li, B., Li, J. -H., Liao, H., Lincoln, D., Linssen, L., Lipton, R., Liu, Y., Lobanov, A., Lu, R. S., Lysova, I., Magnan, A. M., Magniette, F., Maier, A. A., Malakhov, A., Mandjavize, I., Mannelli, M., Mans, J., Marchioro, A., Martelli, A., Masterson, P., Meng, B., Mengke, T., Mestvirishvili, A., Mirza, I., Moccia, S., Morrissey, I., Mudholkar, T., Musić, J., Musienko, I., Nabili, S., Nagar, A., Nikitenko, A., Noonan, D., Noy, M., Nurdan, K., Ochando, C., Odegard, B., Odell, N., Onel, Y., Ortez, W., Ozegović, J., Rodriguez, L. Pacheco, Paganis, E., Pagenkopf, D., Palladino, V., Pandey, S., Pantaleo, F., Papageorgakis, C., Papakrivopoulos, I., Parshook, J., Pastika, N., Paulini, M., Paulitsch, P., Peltola, T., Gomes, R. Pereira, Perkins, H., Petiot, P., Pitters, F., Prosper, H., Prvan, M., Puljak, I., Quast, T., Quinn, R., Quinnan, M., Rapacz, K., Raux, L., Reichenbach, G., Reinecke, M., Revering, M., Rodriguez, A., Romanteau, T., Rose, A., Rovere, M., Roy, A., Rubinov, P., Rusack, R., Simsek, A. E., Sozbilir, U., Sahin, O. M., Sanchez, A., Saradhy, R., Sarkar, T., Sarkisla, M. A., Sauvan, J. B., Schmidt, I., Schmitt, M., Scott, E., Seez, C., Sefkow, F., Sharma, S., Shein, I., Shenai, A., Shukla, R., Sicking, E., Sieberer, P., Sirois, Y., Smirnov, V., Spencer, E., Steen, A., Strait, J., Strebler, T., Strobbe, N., Su, J. W., Sukhov, E., Sun, L., Sun, M., Syal, C., Tali, B., Tok, U. G., Topaksu, A. Kayis, Tan, C. L., Tastan, I., Tatli, T., Thaus, R., Tekten, S., Thienpont, D., Pierre-Emile, T., Tiras, E., Titov, M., Tlisov, D., Troska, J., Tsamalaidze, Z., Tsipolitis, G., Tsirou, A., Tyurin, N., Undleeb, S., Urbanski, D., Ustinov, V., Uzunian, A., van de Klundert, M., Varela, J., Velasco, M., Pinto, M. Vicente Barreto, da Silva, P. M., Virdee, T., de Oliveira, R. Vizinho, Voelker, J., Voirin, E., Wang, Z., Wang, X., Wang, F., Wayne, M., Webb, S. N., Weinberg, M., Whitbeck, A., White, D., Wickwire, R., Wilson, J. S., Wu, H. Y., Wu, L., Yeh, C. H, Yohay, R., Yu, G. B., Yu, S. S., Yu, D., Yumiceva, F., Zacharopoulou, A., Zamiatin, N., Zarubin, A., Zenz, S., Zhang, H., and Zhang, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The CMS experiment at the CERN LHC will be upgraded to accommodate the 5-fold increase in the instantaneous luminosity expected at the High-Luminosity LHC (HL-LHC). Concomitant with this increase will be an increase in the number of interactions in each bunch crossing and a significant increase in the total ionising dose and fluence. One part of this upgrade is the replacement of the current endcap calorimeters with a high granularity sampling calorimeter equipped with silicon sensors, designed to manage the high collision rates. As part of the development of this calorimeter, a series of beam tests have been conducted with different sampling configurations using prototype segmented silicon detectors. In the most recent of these tests, conducted in late 2018 at the CERN SPS, the performance of a prototype calorimeter equipped with ${\approx}12,000\rm{~channels}$ of silicon sensors was studied with beams of high-energy electrons, pions and muons. This paper describes the custom-built scalable data acquisition system that was built with readily available FPGA mezzanines and low-cost Raspberry PI computers.

Published
2020
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6. Cryotherapy in pediatric airway

Author

Schramm, D, primary, Freitag, N, additional, Kötz, K, additional, Iglesias-Serrano, I, additional, Culebras-Amigo, M, additional, Koblizek, V, additional, Pérez-Tarazona, S, additional, Cases Viedma, E, additional, Srikanta, J, additional, Durdik, P, additional, Darwiche, K, additional, Rubak, S, additional, and Stafler, P, additional

Published
2022
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10. WS4.4 Multicenter prevalence study of nontuberculous mycobacteria in patients with cystic fibrosis in Scandinavia

Author

Qvist, T., primary, Jönsson, B., additional, Gilljam, M., additional, Svahn, A., additional, Jensen-Fangel, S., additional, Kötz, K., additional, Wang, M., additional, Hansson, L., additional, Krjukova, J., additional, Hollsing, A., additional, Finstad, P.L., additional, Laerum, B.N., additional, Høiby, N., additional, Pressler, T., additional, and Katzenstein, T.L., additional

Published
2014
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14. Late clinical manifestation of cerebral tuberculomas in two children with tuberculous meningoencephalitis.

Author

Rolinck-Werninghaus, Claudia, Kötz, Karsten, Magdorf, Klaus, Bunikowski, Rita, Staab, Doris, Wahn, Ulrich, Rolinck-Werninghaus, C, Kötz, K, Magdorf, K, Bunikowski, R, Staab, D, and Wahn, U

Subjects
TUBERCULOSIS complications, DRUG therapy, BRAIN diseases, THERAPEUTICS
Abstract

Unlabelled: We report on two children with cerebral tuberculomas leading to late dramatic clinical exacerbation after appropriate antituberculous chemotherapy and high-dose corticosteroids. A 6-year-old girl with tuberculous meningoencephalitis initially fully recovered. However, after 9 months of continuous therapy she presented with acute increased intracranial pressure caused by tuberculomas requiring rapid drainage of CSF. A 16-year-old boy with miliary pulmonary tuberculosis and severe meningoencephalitis had reached a stable condition for more than 10 months although still suffering from a left-dominant spasticity and motor dysphasia. Fifteen months after initiation of therapy he presented with an acute central paralysis of the left facial nerve, progressive hemiplegia, severe ataxia and increasing lethargy caused by a cerebral tuberculoma with a perifocal oedema. Prolonged treatment with antituberculous chemotherapy and high-dose corticosteroids led to complete recovery in the younger patient and marked improvement in the older patient who remains severely handicapped.Conclusion: Patients with initially successful treatment of central nervous system tuberculosis should undergo an alert follow-up for the development of late cerebral tuberculomas. Treatment should consist of prolonged courses of antituberculous chemotherapy and high-dose corticosteroids. [ABSTRACT FROM AUTHOR]

Published
2001
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15. Cryotherapy in the paediatric airway: Indications, success and safety

Author

Dirk Schramm, Nadine Freitag, Karsten Kötz, Ignacio Iglesias‐Serrano, Mario Culebras‐Amigo, Vladimir Koblizek, Santiago Pérez‐Tarazona, Enrique Cases Viedma, JT Srikanta, Peter Durdik, Kaid Darwiche, Sune Rubak, Patrick Stafler, Institut Català de la Salut, [Schramm D, Freitag N] Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. [Kötz K] Queen Silvias Children Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden. [Iglesias-Serrano I] Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Culebras-Amigo M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Koblizek V] Department of Pneumology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University, Prague, Czechia, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Pulmonary and Respiratory Medicine, Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Respiratory System::Bronchoscopy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Medizin, Therapeutics::Cryotherapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], cryobiopsy, Bronchi, personas::Grupos de Edad::niño [DENOMINACIONES DE GRUPOS], Respiratory System::Lung::Bronchi [ANATOMY], Bronquis, Broncoscòpia, paediatric bronchoscopy, Bronchoscopy, interventional bronchoscopy, diagnóstico::técnicas y procedimientos diagnósticos::técnicas diagnósticas respiratorias::broncoscopia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Humans, Prospective Studies, Child, airway obstruction, foreign body removal, Persons::Age Groups::Child [NAMED GROUPS], Foreign Bodies, sistema respiratorio::pulmón::bronquios [ANATOMÍA], Cryotherapy, cryotherapy, Infants, Fred - Ús terapèutic, terapéutica::crioterapia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
Abstract

Airway obstruction; Cryobiopsy; Paediatric bronchoscopy Obstrucción de las vías respiratorias; Criobiopsia; Broncoscopia pediátrica Obstrucció de les vies respiratòries; Criobiòpsia; Broncoscòpia pediàtrica Background and objective Cryotherapy in interventional bronchoscopy is a new treatment modality, which has recently been made available for the paediatric airway. Lack of experience and safety concerns have led to hesitant adaptation. The aim of this study was to assess indications, success rates and complications of airway cryotherapy in children. Methods Bronchoscopists from medical centre performing cryotherapy in patients between 0 and 18 years were invited to participate in a prospective study based on an online questionnaire. Patient and participant data were collected between June 2020 and June 2021. Results A total of 69 cryotherapy procedures were performed in 57 patients a for three main indications: Biopsy (30), restoration of airway patency (23) and foreign body aspiration (16). The overall success rate was 93%, the remaining 7% were performed for foreign body removal and required a switch of technique. Restoration of airway patency was successfully applied in various pathologies, including mucus plugs, bronchial casts and post traumatic stenosis. The diagnostic yield of transbronchial biopsies was 96%. No severe complications were encountered; one pneumothorax following a cryobiopsy required a chest drain for 48 h. No child was admitted to intensive care or died from a procedural complication. Conclusion In this largest paediatric case collection to date, cryotherapy was safe and carried a high success rate. Cryobiopsy compares favourably to the widely used forceps biopsy and could replace it in the future. Paediatric bronchoscopists are encouraged to add cryotherapy to their armamentarium of airway interventions. Open Access funding enabled and organized by Projekt DEAL.

Published
2022
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16. Analyses of 1236 genotyped primary ciliary dyskinesia individuals identify regional clusters of distinct DNA variants and significant genotype-phenotype correlations.

Author

Raidt J, Riepenhausen S, Pennekamp P, Olbrich H, Amirav I, Athanazio RA, Aviram M, Balinotti JE, Bar-On O, Bode SFN, Boon M, Borrelli M, Carr SB, Crowley S, Dehlink E, Diepenhorst S, Durdik P, Dworniczak B, Emiralioğlu N, Erdem E, Fonnesu R, Gracci S, Große-Onnebrink J, Gwozdziewicz K, Haarman EG, Hansen CR, Hogg C, Holgersen MG, Kerem E, Körner RW, Kötz K, Kouis P, Loebinger MR, Lorent N, Lucas JS, Maj D, Mall MA, Marthin JK, Martinu V, Mazurek H, Mitchison HM, Nöthe-Menchen T, Özçelik U, Pifferi M, Pogorzelski A, Ringshausen FC, Roehmel JF, Rovira-Amigo S, Rumman N, Schlegtendal A, Shoemark A, Sperstad Kennelly S, Staar BO, Sutharsan S, Thomas S, Ullmann N, Varghese J, von Hardenberg S, Walker WT, Wetzke M, Witt M, Yiallouros P, Zschocke A, Ziętkiewicz E, Nielsen KG, and Omran H

Subjects
Humans, Male, Female, Adult, Child, Adolescent, Young Adult, Middle Aged, Europe, Registries, Axonemal Dyneins genetics, Forced Expiratory Volume, Child, Preschool, Kartagener Syndrome genetics, Kartagener Syndrome physiopathology, Genetic Variation, Mutation, Aged, Infant, Cytoskeletal Proteins, Proteins, Genotype, Genetic Association Studies, Phenotype
Abstract

Background: Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient ciliary airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship to diagnostic findings and clinical phenotypes., Methods: Genetic variants and clinical findings (age, sex, body mass index, laterality defects, forced expiratory volume in 1 s (FEV 1 )) were collected from 19 countries using the European Reference Network's ERN-LUNG international PCD Registry. Genetic data were evaluated according to American College of Medical Genetics and Genomics guidelines. We assessed regional distribution of implicated genes and genetic variants as well as genotype correlations with laterality defects and FEV 1 ., Results: The study included 1236 individuals carrying 908 distinct pathogenic DNA variants in 46 PCD genes. We found considerable variation in the distribution of PCD genotypes across countries due to the presence of distinct founder variants. The prevalence of PCD genotypes associated with pathognomonic ultrastructural defects (mean 72%, range 47-100%) and laterality defects (mean 42%, range 28-69%) varied widely among countries. The prevalence of laterality defects was significantly lower in PCD individuals without pathognomonic ciliary ultrastructure defects (18%). The PCD cohort had a reduced median FEV 1 z-score (-1.66). Median FEV 1 z-scores were significantly lower in CCNO (-3.26), CCDC39 (-2.49) and CCDC40 (-2.96) variant groups, while the FEV 1 z-score reductions were significantly milder in DNAH11 (-0.83) and ODAD1 (-0.85) variant groups compared to the whole PCD cohort., Conclusion: This unprecedented multinational dataset of DNA variants and information on their distribution across countries facilitates interpretation of the genetic epidemiology of PCD and indicates that the genetic variant can predict diagnostic and phenotypic features such as the course of lung function., Competing Interests: Conflict of interest: The authors have no potential conflicts of interest to disclose., (Copyright ©The authors 2024.)

Published
2024
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17. Diffuse alveolar haemorrhage in children: an international multicentre study.

Author

Ring AM, Schwerk N, Kiper N, Aslan AT, Aurora P, Ayats R, Azevedo I, Bandeira T, Carlens J, Castillo-Corullon S, Cobanoglu N, Elnazir B, Emiralioğlu N, Eyuboglu TS, Fayon M, Gursoy TR, Hogg C, Kötz K, Karadag B, Látalová V, Krenke K, Lange J, Manali ED, Osona B, Papiris S, Proesmann M, Reix P, Roditis L, Rubak S, Rumman N, Snijders D, Stehling F, Weiss L, Yalcın E, Zirek F, Bush A, Clement A, Griese M, Buchvald FF, Nathan N, and Nielsen KG

Abstract

Background: Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome., Methods: A retrospective, descriptive multicentre follow-up study initiated from the European network for translational research in children's and adult interstitial lung disease (Cost Action CA16125) and chILD-EU CRC (the European Research Collaboration for Children's Interstitial Lung Disease). Inclusion criteria were DAH of any cause diagnosed before the age of 18 years., Results: Data of 124 patients from 26 centres (15 counties) were submitted, of whom 117 patients fulfilled the inclusion criteria. Diagnoses were idiopathic pulmonary haemosiderosis (n=35), DAH associated with autoimmune features (n=20), systemic and collagen disorders (n=18), immuno-allergic conditions (n=10), other childhood interstitial lung diseases (chILD) (n=5), autoinflammatory diseases (n=3), DAH secondary to other conditions (n=21) and nonspecified DAH (n=5). Median (IQR) age at onset was 5 (2.0-12.9) years. Most frequent clinical presentations were anaemia (87%), haemoptysis (42%), dyspnoea (35%) and cough (32%). Respiratory symptoms were absent in 23%. The most frequent medical treatment was systemic corticosteroids (93%), hydroxychloroquine (35%) and azathioprine (27%). Overall mortality was 13%. Long-term data demonstrated persistent abnormal radiology and a limited improvement in lung function., Conclusions: Paediatric DAH is highly heterogeneous regarding underlying causes and clinical presentation. The high mortality rate and number of patients with ongoing treatment years after onset of disease underline that DAH is a severe and often chronic condition. This large international study paves the way for further prospective clinical trials that will in the long term allow evidence-based treatment and follow-up recommendations to be determined., Competing Interests: Conflicts of interest: T. Bandeira reports personal fees from Sanofi and other support from Boehringer Ingelheim, outside the submitted work. Conflicts of interest: E.D. Manali reports other from Boehringer Ingelheim, other from Bering, other from Hoffman la Roche, outside the submitted work. Conflicts of interest: S. Papiris reports grants and other support from Boehringer Ingelheim and Hoffman la Roche, and other support from Savara, outside the submitted work. Conflicts of interest: M. Griese reports grants, personal fees and nonfinancial support from Boehringer Ingelheim for an advisory board on nintedanib, outside the submitted work. Conflicts of interest: The remaining authors have nothing to disclose., (Copyright ©The authors 2023.)

Published
2023
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18. Cryotherapy in the paediatric airway: Indications, success and safety.

Author

Schramm D, Freitag N, Kötz K, Iglesias-Serrano I, Culebras-Amigo M, Koblizek V, Pérez-Tarazona S, Cases Viedma E, Srikanta JT, Durdik P, Darwiche K, Rubak S, and Stafler P

Subjects
Bronchi, Child, Cryotherapy adverse effects, Cryotherapy methods, Humans, Prospective Studies, Bronchoscopy adverse effects, Bronchoscopy methods, Foreign Bodies etiology, Foreign Bodies therapy
Abstract

Background and Objective: Cryotherapy in interventional bronchoscopy is a new treatment modality, which has recently been made available for the paediatric airway. Lack of experience and safety concerns have led to hesitant adaptation. The aim of this study was to assess indications, success rates and complications of airway cryotherapy in children., Methods: Bronchoscopists from medical centre performing cryotherapy in patients between 0 and 18 years were invited to participate in a prospective study based on an online questionnaire. Patient and participant data were collected between June 2020 and June 2021., Results: A total of 69 cryotherapy procedures were performed in 57 patients a for three main indications: Biopsy (30), restoration of airway patency (23) and foreign body aspiration (16). The overall success rate was 93%, the remaining 7% were performed for foreign body removal and required a switch of technique. Restoration of airway patency was successfully applied in various pathologies, including mucus plugs, bronchial casts and post traumatic stenosis. The diagnostic yield of transbronchial biopsies was 96%. No severe complications were encountered; one pneumothorax following a cryobiopsy required a chest drain for 48 h. No child was admitted to intensive care or died from a procedural complication., Conclusion: In this largest paediatric case collection to date, cryotherapy was safe and carried a high success rate. Cryobiopsy compares favourably to the widely used forceps biopsy and could replace it in the future. Paediatric bronchoscopists are encouraged to add cryotherapy to their armamentarium of airway interventions., (© 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.)

Published
2022
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19. Comparison of cine and real-time cardiac MRI in rhesus macaques.

Author

Moussavi A, Mißbach S, Serrano Ferrel C, Ghasemipour H, Kötz K, Drummer C, Behr R, Zimmermann WH, and Boretius S

Subjects
Animals, Heart physiology, Heart Function Tests, Macaca mulatta, Translational Research, Biomedical, Ventricular Function, Left, Heart diagnostic imaging, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging, Cine methods
Abstract

Cardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Real-Time (RT) cardiac MRI has been tested in a cohort of ten adult rhesus macaques using a clinical MR-system. In spite of lower tissue contrast and sharpness of RT-MRI, cardiac functions were similarly well assessed by RT-MRI compared to cine MRI (similar intra-subject repeatability). However, systematic underestimation of the end-diastolic volume (31 ± 9%), end-systolic volume (20 ± 11%), stroke volume (40 ± 12%) and ejection fraction (13 ± 9%) hamper the comparability of RT-MRI results with those of other cardiac MRI methods. Yet, the underestimations were very consistent (< 5% variability) for repetitive measurements, making RT-MRI an appropriate alternative to cine MRI for longitudinal studies. In addition, RT-MRI enabled the analysis of cardio-respiratory coupling. All functional parameters showed lower values during expiration compared to inspiration, most likely due to the pressure-controlled artificial ventilation. In conclusion, despite systematic underestimation of the functional parameters, RT-MRI allowed the assessment of left ventricular function in macaques with significantly less experimental effort, measurement time, risk and burden for the animals compared to cine MRI.

Published
2021
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20. Access to medicines for rare diseases: beating the drum for primary ciliary dyskinesia.

Author

Crowley S, Azevedo I, Boon M, Bush A, Eber E, Haarman E, Karadag B, Kötz K, Leigh M, Moreno-Galdó A, Mussaffi H, Nielsen KG, Omran H, Papon JF, Pohunek P, Priftis K, Rindlisbacher B, Santamaria F, Valiulis A, Witt M, Yiallouros P, Zivkovic Z, Kuehni CE, and Lucas JS

Abstract

Primary ciliary dyskinesia, a rare disease causing bronchiectasis, lacks a sound evidence base for treatment. @beatpcd proposes 1) forming a PCD European clinical trial network to address this situation and 2) conducting n-of-1 trials to access medication. https://bit.ly/3j5blfM., Competing Interests: Conflict of interest: S. Crowley has nothing to disclose. Conflict of interest: I. Azevedo has nothing to disclose. Conflict of interest: M. Boon reports grants from Horizon 2020 MyCyFAPP and KOOR post-doctoral funding from University Hospital Leuven, outside the submitted work. Conflict of interest: A. Bush has nothing to disclose. Conflict of interest: E. Eber has nothing to disclose. Conflict of interest: E. Haarman has nothing to disclose. Conflict of interest: B. Karadag has nothing to disclose. Conflict of interest: K. Kötz has nothing to disclose. Conflict of interest: M. Leigh reports a primary ciliary dyskinesia (PCD) research grant from the National Institutes of Health and a grant for a PCD clinical trial from Parion Sciences, outside the submitted work. Conflict of interest: A. Moreno-Galdó reports support for travel to and registration for medical conferences from Actelion, Abbvie and Novartis, outside the submitted work. Conflict of interest: H. Mussaffi has nothing to disclose. Conflict of interest: K.G. Nielsen has nothing to disclose. Conflict of interest: H. Omran has nothing to disclose Conflict of interest: J-F. Papon has nothing to disclose. Conflict of interest: P. Pohunek reports grants from the Ministry of Health, Czech Republic, during the conduct of the study. Conflict of interest: K. Priftis has nothing to disclose. Conflict of interest: B. Rindlisbacher has nothing to disclose. Conflict of interest: F. Santamaria has nothing to disclose. Conflict of interest: A. Valiulis has nothing to disclose. Conflict of interest: M. Witt has nothing to disclose. Conflict of interest: P. Yiallouros has nothing to disclose. Conflict of interest: Z. Zivkovic has nothing to disclose Conflict of interest: C.E. Kuehni reports grants from Swiss National Science Foundation during the conduct of the study. Conflict of interest: J.S. Lucas has nothing to disclose., (Copyright ©ERS 2020.)

Published
2020
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21. Relation between BCG vaccine scar and an interferon-gamma release assay in immigrant children with "positive" tuberculin skin test (≥10 mm).

Author

Gudjónsdóttir MJ, Kötz K, Nielsen RS, Wilmar P, Olausson S, Wallmyr D, and Trollfors B

Subjects
Adolescent, Child, Child, Preschool, Emigrants and Immigrants, Female, Humans, Infant, Infant, Newborn, Latent Tuberculosis diagnosis, Male, Retrospective Studies, Sweden, Tuberculin Test methods, Tuberculosis diagnosis, Tuberculosis epidemiology, Vaccination, BCG Vaccine adverse effects, Cicatrix etiology, Cicatrix pathology, Interferon-gamma Release Tests methods
Abstract

Background: Immigrants from countries with high incidence of tuberculosis (TB) are usually offered screening when they arrive to low incidence countries. The tuberculin skin test (TST) is often used. The interferon gamma release assays (IGRAs) are more specific and not affected by BCG vaccination. The aims of this study were 1. To see if there if there is a correlation between a positive IGRA (QFT) and presence of a BCG scar in children with TST ≥10 mm, 2. To compare the TST diameter with QFT result, 3. To see if chest X-ray can be omitted in QFT negative children despite TST ≥10 mm., Methods: 762 healthy children/adolescents (median age 14 years) arriving to Gothenburg and surroundings with TST ≥10 mm were tested with QFT., Results: A total of 163/492 (33 %) children with BCG scar had positive QFT, whereas 205/270 (76 %) without BCG scar had positive QFT (p < 0.0001). The median TST was 12 mm in QFT negative and 18 mm in QFT positive children (p < 0.0001) but with considerable overlap. Median TST was the same (12 mm) in QFT negative children with and without BCG scar. Among the QFT positive children 25/368 had chest X-ray changes compared to 2/393 among the QFT negative children (p < 0.0007)., Conclusions: Previous BCG vaccination had an effect on the TST diameter so an IGRA is recommended to diagnose latent TB. Using only TST for screening of latent TB would lead to overdiagnosis. The TST diameter was larger in QFT positive than in QFT negative children but could not predict QFT in the individual patient. Chest X ray contributes little to the diagnosis of TB in QFT negative children but can not be omitted because of late seroconversion of QFT in some patients., Trial Registration: Not applicable.

Published
2016
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22. Treatment and Follow-Up of Patients with Long-Gap Esophageal Atresia: 15 Years' of Experience from the Western Region of Sweden.

Author

Jönsson L, Friberg LG, Gatzinsky V, Kötz K, Sillén U, and Abrahamsson K

Subjects
Anastomosis, Surgical, Anastomotic Leak, Bronchoscopy, Child, Esophageal Atresia complications, Female, Gastroesophageal Reflux etiology, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Lung Diseases complications, Male, Proton Pump Inhibitors therapeutic use, Retrospective Studies, Spirometry, Sweden, Esophageal Atresia surgery, Esophagus surgery, Gastrostomy
Abstract

Objective: This retrospective study aims to report treatment results in patients with long-gap esophageal atresia (LGEA), gross A + B type, and discuss the value of different clinical findings and physiological tests in the follow-up., Methods: This retrospective observational study comprises all patients with LGEA admitted to our department between 1995 and 2010., Results: A total of 16 patients were included. Their mean gestational age was 35(+2) weeks and their mean birth weight was 1,945 g (-2.5 standard deviation scores). No catch-up growth in height could be seen and they remained smaller than the average population during the study period. Gastrostomy was performed as the first surgical procedure. Overall, 11 of the 16 patients had a delayed primary anastomosis. Elongation of the distal esophageal segment was required in 3 of the 16 patients and a colonic interposition in 2 of the 16 patients. The median age at definitive surgery was 150 days. All the patients had gastroesophageal reflux after their definitive surgery. Three of the 16 patients required surgery due to aspiration and all 3 had a pathological lung clearance index (LCI) at multiple-breath washout (MBW). At the age of 1 or 7 years, the LCI was pathological in 4 of the 14 patients, and spirometry showed an obstruction in 9 of the 14 patients., Conclusion: LGEA is a severe congenital malformation, with severe morbidity. No mortality was seen. MBW could be a useful tool for the early detection of progressive pulmonary damage., (Georg Thieme Verlag KG Stuttgart · New York.)

Published
2016
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23. Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia.

Author

Qvist T, Gilljam M, Jönsson B, Taylor-Robinson D, Jensen-Fangel S, Wang M, Svahn A, Kötz K, Hansson L, Hollsing A, Hansen CR, Finstad PL, Pressler T, Høiby N, and Katzenstein TL

Subjects
Adolescent, Adult, Age Distribution, Cohort Studies, Comorbidity, Female, Humans, Male, Mycobacterium Infections, Nontuberculous diagnosis, Prevalence, Retrospective Studies, Scandinavian and Nordic Countries epidemiology, Severity of Illness Index, Sex Distribution, Young Adult, Cystic Fibrosis epidemiology, Cystic Fibrosis microbiology, Mycobacterium Infections, Nontuberculous epidemiology, Nontuberculous Mycobacteria isolation & purification
Abstract

Background: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described., Methods: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics., Results: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died., Conclusion: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome., (Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2015
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24. [Prevention of folic acid-induced malformations--recommendations and reality].

Author

Rösch C, Steinbicker V, Kolbe M, Lehmann R, and Kötz K

Subjects
Congenital Abnormalities epidemiology, Female, Germany epidemiology, Humans, Infant, Newborn, Pregnancy, Prospective Studies, Congenital Abnormalities prevention & control, Folic Acid therapeutic use
Abstract

Periconceptional intake of folic acid is one of only few possibilities of preventing congenital malformations. We report on the update situation of applying folic acid and the effects on the prevalence of neural tube defects and oral clefts. The analysis is based on data of the malformation registry in Saxony-Anhalt. A common public campaign on the benefit of folic acid protection is presented.

Published
1999

25. Quantitative assessment of immediate cutaneous hypersensitivity in a model of genetic predisposition to atopy.

Author

Daser A, Bätjer N, Kölsch U, Kötz K, Schmeling H, Schou C, and Renz H

Subjects
Allergens immunology, Animals, Disease Models, Animal, Female, Genetic Predisposition to Disease immunology, Immunization, Mice, Mice, Inbred A, Mice, Inbred AKR, Mice, Inbred C57BL, Phenotype, Pollen immunology, Skin Tests methods, Dermatitis, Atopic immunology, Hypersensitivity, Immediate diagnosis, Hypersensitivity, Immediate genetics, Hypersensitivity, Immediate immunology
Abstract

Genetic predisposition and environmental factors modulate the expression of allergic phenotypes. The frequent allergic phenotype 'immediate cutaneous hypersensitivity' was established in mice as a model for atopy. Genetic dissection of this trait requires a robust procedure to assess the allergic phenotype. To this end, different mouse strains were immunized with birch pollen extract. Immediate cutaneous hypersensitivity reactions were induced through intradermal allergen exposure. Wheel formation was quantitated and expressed as a hypersensitivity score according to the bonitur method. This procedure identified A/J and C57BL/6 mice as high- and low-responder strains, respectively. Crosses of A/J and C57BL/6 mice should allow the characterization of mendelian factors responsible for the two extreme phenotypes identified here.

Published
1998
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26. Immunoglobulin G galactosylation deficiency determined by isoelectric focusing and lectin affinoblotting in differential diagnosis of rheumatoid arthritis.

Author

Kötz K, Hänsler M, Sauer H, Kaltenhäuser S, and Häntzschel H

Subjects
Arthritis, Rheumatoid immunology, Diagnosis, Differential, Follow-Up Studies, Glycosylation, Humans, Lectins, Arthritis, Rheumatoid diagnosis, Galactose metabolism, Immunoglobulin G blood, Isoelectric Focusing methods
Abstract

IgG galactosylation deficiency in patients with rheumatoid arthritis (RA) can be detected by isoelectric focusing (IEF)/lectin affinoblotting. We analyzed IgG glycosylation in patients with early arthritis (n = 50) and healthy controls in order to determine the clinical value of this parameter in differential diagnosis of RA. A significant correlation between the IgG galactosylation defect at disease onset and the diagnosis of RA during the follow-up was observed. Involvement of other clinical parameters (erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor) did not improve the predictive value of IgG galactosylation changes.

Published
1996
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27. Detection of immunoglobulin G glycosylation changes in patients with rheumatoid arthritis by means of isoelectric focusing and lectin-affinoblotting.

Author

Hänsler M, Kötz K, and Häntzschel H

Subjects
Electrophoresis, Polyacrylamide Gel methods, Glycosylation, Humans, Lectins, Ricin, Synovitis immunology, Arthritis, Rheumatoid immunology, Immunoblotting methods, Immunoglobulin G metabolism, Isoelectric Focusing methods, Plant Lectins
Abstract

Patients with rheumatoid arthritis have a reduced prevalence of immunoglobulin G (IgG) oligosaccharide chains terminating in galactose, thus exposing N-acetylglucosamine. We analyzed IgG glycosylation in patients with rheumatoid arthritis, patients with early synovitis, and in controls by means of isoelectric focusing and lectin-affinoblotting. The ratio of N-terminal N-acetylglucosamine and galactose was determined using specific biotin-labeled lectins. The IgG glycosylation state may well be of clinical value in the differential diagnosis of patients presenting with early synovitis.

Published
1995
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