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3. S3-Leitlinie – Diagnostik und Therapie biliärer Karzinome

Author

Bitzer, M., Voesch, S., Albert, J., Bartenstein, P., Bechstein, W., Blödt, S., Brunner, T., Dombrowski, F., Evert, M., Follmann, M., La Fougère, C., Freudenberger, P., Geier, A., Gkika, E., Götz, M., Hammes, E., Helmberger, T., Hoffmann, R.T., Hofmann, W.P., Huppert, P., Kautz, A., Knötgen, G., Körber, J., Krug, D., Lammert, F., Lang, H., Langer, T., Lenz, P., Mahnken, A., Meining, A., Micke, O., Nadalin, S., Nguyen, H.P., Ockenga, J., Oldhafer, K., Paprottka, P., Paradies, K., Pereira, P., Persigehl, T., Plauth, M., Plentz, R., Pohl, J., Riemer, J., Reimer, P., Ringwald, J., Ritterbusch, Ulrike, Roeb, E., Schellhaas, B., Schirmacher, P., Schmid, I., Schuler, A., von Schweinitz, D., Seehofer, D., Sinn, M., Stein, A., Stengel, A., Steubesand, N., Stoll, C., Tannapfel, A., Taubert, A., Trojan, J., van Thiel, I., Tholen, R., Vogel, A., Vogl, T., Vorwerk, H., Wacker, F., Waidmann, O., Wedemeyer, H., Wege, H., Wildner, D., Wittekind, C., Wörns, M.A., Galle, P., and Malek, N.

Subjects
Medizin
Published
2022

4. S3-Leitlinie – Diagnostik und Therapie biliärer Karzinome

Author

Bitzer, M., additional, Voesch, S., additional, Albert, J., additional, Bartenstein, P., additional, Bechstein, W., additional, Blödt, S., additional, Brunner, T., additional, Dombrowski, F., additional, Evert, M., additional, Follmann, M., additional, La Fougère, C., additional, Freudenberger, P., additional, Geier, A., additional, Gkika, E., additional, Götz, M., additional, Hammes, E., additional, Helmberger, T., additional, Hoffmann, R. T., additional, Hofmann, W. P., additional, Huppert, P., additional, Kautz, A., additional, Knötgen, G., additional, Körber, J., additional, Krug, D., additional, Lammert, F., additional, Lang, H., additional, Langer, T., additional, Lenz, P., additional, Mahnken, A., additional, Meining, A., additional, Micke, O., additional, Nadalin, S., additional, Nguyen, H. P., additional, Ockenga, J., additional, Oldhafer, K., additional, Paprottka, P., additional, Paradies, K., additional, Pereira, P., additional, Persigehl, T., additional, Plauth, M., additional, Plentz, R., additional, Pohl, J., additional, Riemer, J., additional, Reimer, P., additional, Ringwald, J., additional, Ritterbusch, U., additional, Roeb, E., additional, Schellhaas, B., additional, Schirmacher, P., additional, Schmid, I., additional, Schuler, A., additional, von Schweinitz, D., additional, Seehofer, D., additional, Sinn, M., additional, Stein, A., additional, Stengel, A., additional, Steubesand, N., additional, Stoll, C., additional, Tannapfel, A., additional, Taubert, A., additional, Trojan, J., additional, van Thiel, I., additional, Tholen, R., additional, Vogel, A., additional, Vogl, T., additional, Vorwerk, H., additional, Wacker, F., additional, Waidmann, O., additional, Wedemeyer, H., additional, Wege, H., additional, Wildner, D., additional, Wittekind, C., additional, Wörns, M. A., additional, Galle, P., additional, and Malek, N., additional

Published
2022
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20. Seasonal methane accumulation and release from a gas emission site in the central North Sea

Author

Mau, S., Gentz, T., Körber, J.-H., Torres, M. E., Römer, M., Sahling, H., Wintersteller, P., Martinez, R., Schlüter, M., Helmke, E., Mau, S., Gentz, T., Körber, J.-H., Torres, M. E., Römer, M., Sahling, H., Wintersteller, P., Martinez, R., Schlüter, M., and Helmke, E.

Abstract

We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the seasonal thermocline in summer with a median concentration of 390 nM, whereas during winter, methane concentrations were typically much lower (median concentration of 22 nM). High-resolution methane analysis using an underwater mass-spectrometer confirmed our summer results and was used to document prevailing stratification over the tidal cycle. We contrast estimates of methane oxidation rates (from 0.1 to 4.0 nM day−1) using the traditional approach scaled to methane concentrations with microbial turnover time values and suggest that the scaling to concentration may obscure the ecosystem microbial activity when comparing systems with different methane concentrations. Our measured and averaged rate constants (k') were on the order of 0.01 day−1, equivalent to a turnover time of 100 days, even when summer stratification led to enhanced methane concentrations in the bottom water. Consistent with these observations, we could not detect known methanotrophs and pmoA genes in water samples collected during both seasons. Estimated methane fluxes indicate that horizontal transport is the dominant process dispersing the methane plume. During periods of high wind speed (winter), more methane is lost to the atmosphere than oxidized in the water. Microbial oxidation seems of minor importance throughout the year.

Published
2015

22. S3-Leitlinie 'Magenkarzinom' – Diagnostik und Therapie der Adenokarzinome des Magens und ösophagogastralen Übergangs

Author

Moehler, M., Al-Batran, S. E., Andus, T., Anthuber, M., Arends, J., Arnold, D., Aust, D., Baier, P., Baretton, G., Bernhardt, J., Boeing, H., Böhle, E., Bokemeyer, C., Bornschein, J., Budach, W., Burmester, E., Caca, K., Diemer, W. A., Dietrich, C. F., Ebert, M., Eickhoff, A., Ell, C., Fahlke, J., Feussner, H., Fietkau, R., Fischbach, W., Fleig, W., Flentje, M., Gabbert, H. E., Galle, P. R., Geissler, M., Gockel, I., Graeven, U., Grenacher, L., Gross, S., Hartmann, J. T., Heike, M., Heinemann, V., Herbst, B., Herrmann, T., Höcht, S., Hofheinz, R. D., Höfler, H., Höhler, T., Hölscher, A. H., Horneber, M., Hübner, J., Izbicki, J. R., Jakobs, R., Jenssen, C., Kanzler, S., Keller, M., Kiesslich, R., Klautke, G., Körber, J., Krause, B. J., Kuhn, C., Kullmann, F., Lang, H., Link, H., Lordick, F., Ludwig, K., Lutz, M., Mahlberg, R., Malfertheiner, P., Merkel, S., Messmann, H., Meyer, H. J., Mönig, S., Piso, P., Pistorius, S., Porschen, R., Rabenstein, T., Reichardt, P., Ridwelski, K., Röcken, C., Roetzer, I., Rohr, P., Schepp, W., Schlag, P. M., Schmid, R. M., Schmidberger, H., Schmiegel, W. H., Schmoll, H. J., Schuch, G., Schuhmacher, C., Schütte, K., Schwenk, W., Selgrad, M., Sendler, A., Seraphin, J., Seufferlein, T., Stahl, Michael, Stein, H., Stoll, C., Stuschke, Martin, Tannapfel, A., Tholen, R., Thuss-Patience, P., Treml, K., Vanhoefer, Udo Joachim, Vieth, M., Vogelsang, H., Wagner, D., Wedding, U., Weimann, A., Wilke, Hansjochen, Wittekind, C., AWMF, and Bockisch, Andreas (Beitragende*r)

Subjects
Medizin
Published
2011

23. S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des Ösophagus (Langversion 1.0 – September 2015, AWMF-Registernummer: 021/023OL)

Author

Porschen, R., additional, Buck, A., additional, Fischbach, W., additional, Gockel, I., additional, Görling, U., additional, Grenacher, L., additional, Hollerbach, S., additional, Hölscher, A., additional, Körber, J., additional, Messmann, H., additional, Meyer, H., additional, Miehlke, S., additional, Möhler, M., additional, Nöthlings, U., additional, Pech, U., additional, Schmidberger, H., additional, Schmidt, M., additional, Stahl, M., additional, Stuschke, M., additional, Thuss-Patience, P., additional, Trojan, J., additional, Vanhoefer, U., additional, Weimann, A., additional, Wenz, F., additional, and Wullstein, C., additional

Published
2015
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26. 'Far Cortical Locking' (FCL) verbessert die Heilung von mit winkelstabilen Implantaten versorgten Frakturen – ein Tibiafrakturmodel am Schaf

Author

Lesser, M, Körber, J, Klein, K, Augat, P, von Rechenberg, B, and Bottlang, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Die Heilung von Frakturen, die mit winkelstabilen, nicht komprimierenden Implantaten versorgt wurden, beruht auf sekundärer Knochenheilung. Zu steife Implantate können die interfragmentäre Bewegung reduzieren und könnten somit zu minderwertiger Kallusbildung und verzögerter[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2010
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31. Diagnostik und Therapie des hepatozellulären Karzinoms

Author

Greten, T., additional, Malek, N., additional, Schmidt, S., additional, Arends, J., additional, Bartenstein, P., additional, Bechstein, W., additional, Bernatik, T., additional, Bitzer, M., additional, Chavan, A., additional, Dollinger, M., additional, Domagk, D., additional, Drognitz, O., additional, Düx, M., additional, Farkas, S., additional, Folprecht, G., additional, Galle, P., additional, Geißler, M., additional, Gerken, G., additional, Habermehl, D., additional, Helmberger, T., additional, Herfarth, K., additional, Hoffmann, R., additional, Holtmann, M., additional, Huppert, P., additional, Jakobs, T., additional, Keller, M., additional, Klempnauer, J., additional, Kolligs, F., additional, Körber, J., additional, Lang, H., additional, Lehner, F., additional, Lordick, F., additional, Lubienski, A., additional, Manns, M., additional, Mahnken, A., additional, Möhler, M., additional, Mönch, C., additional, Neuhaus, P., additional, Niederau, C., additional, Ocker, M., additional, Otto, G., additional, Pereira, P., additional, Pott, G., additional, Riemer, J., additional, Ringe, K., additional, Ritterbusch, U., additional, Rummeny, E., additional, Schirmacher, P., additional, Schlitt, H., additional, Schlottmann, K., additional, Schmitz, V., additional, Schuler, A., additional, Schulze-Bergkamen, H., additional, von Schweinitz, D., additional, Seehofer, D., additional, Sitter, H., additional, Straßburg, C., additional, Stroszczynski, C., additional, Strobel, D., additional, Tannapfel, A., additional, Trojan, J., additional, van Thiel, I., additional, Vogel, A., additional, Wacker, F., additional, Wedemeyer, H., additional, Wege, H., additional, Weinmann, A., additional, Wittekind, C., additional, Wörmann, B., additional, and Zech, C., additional

Published
2013
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34. S3-Leitlinie „Magenkarzinom” -

Author

Moehler, M., primary, Al-Batran, S.-E., additional, Andus, T., additional, Anthuber, M., additional, Arends, J., additional, Arnold, D., additional, Aust, D., additional, Baier, P., additional, Baretton, G., additional, Bernhardt, J., additional, Boeing, H., additional, Böhle, E., additional, Bokemeyer, C., additional, Bornschein, J., additional, Budach, W., additional, Burmester, E., additional, Caca, K., additional, Diemer, W., additional, Dietrich, C., additional, Ebert, M., additional, Eickhoff, A., additional, Ell, C., additional, Fahlke, J., additional, Feußner, H., additional, Fietkau, R., additional, Fischbach, W., additional, Fleig, W., additional, Flentje, M., additional, Gabbert, H., additional, Galle, P., additional, Geissler, M., additional, Gockel, I., additional, Graeven, U., additional, Grenacher, L., additional, Groß, S., additional, Hartmann, J., additional, Heike, M., additional, Heinemann, V., additional, Herbst, B., additional, Herrmann, T., additional, Höcht, S., additional, Hofheinz, R., additional, Höfler, H., additional, Höhler, T., additional, Hölscher, A., additional, Horneber, M., additional, Hübner, J., additional, Izbicki, J., additional, Jakobs, R., additional, Jenssen, C., additional, Kanzler, S., additional, Keller, M., additional, Kiesslich, R., additional, Klautke, G., additional, Körber, J., additional, Krause, B., additional, Kuhn, C., additional, Kullmann, F., additional, Lang, H., additional, Link, H., additional, Lordick, F., additional, Ludwig, K., additional, Lutz, M., additional, Mahlberg, R., additional, Malfertheiner, P., additional, Merkel, S., additional, Messmann, H., additional, Meyer, H.-J., additional, Mönig, S., additional, Piso, P., additional, Pistorius, S., additional, Porschen, R., additional, Rabenstein, T., additional, Reichardt, P., additional, Ridwelski, K., additional, Röcken, C., additional, Roetzer, I., additional, Rohr, P., additional, Schepp, W., additional, Schlag, P., additional, Schmid, R., additional, Schmidberger, H., additional, Schmiegel, W.-H., additional, Schmoll, H.-J., additional, Schuch, G., additional, Schuhmacher, C., additional, Schütte, K., additional, Schwenk, W., additional, Selgrad, M., additional, Sendler, A., additional, Seraphin, J., additional, Seufferlein, T., additional, Stahl, M., additional, Stein, H., additional, Stoll, C., additional, Stuschke, M., additional, Tannapfel, A., additional, Tholen, R., additional, Thuss-Patience, P., additional, Treml, K., additional, Vanhoefer, U., additional, Vieth, M., additional, Vogelsang, H., additional, Wagner, D., additional, Wedding, U., additional, Weimann, A., additional, Wilke, H., additional, and Wittekind, C., additional

Published
2011
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39. Seasonal methane accumulation and release from a gas emission site in the central North Sea.

Author

Mau, S., Gentz, T., Körber, J. H., Torres, M., Römer, M., Sahling, H., Wintersteller, P., Martinez, R., Schlüter, M., and Helmke, E.

Subjects
UNDERWATER acoustics, METHANE, CLIMATE change, MASS spectrometers, DATA analysis
Abstract

Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect crossing this seep site during a period of seasonal summer stratification (July 2013) and a period of well mixed winter water column (January 2014). Dissolved methane accumulated below the seasonal thermocline in summer with a median concentration of 390 nM, whereas during winter, methane concentrations were much lower (median concentration of nM) and punctually elevated due to bubble transport. High resolution methane analysis by an underwater mass-spectrometer confirmed our summer results and were used to document prevailing stratification over the tidal cycle. Although sufficient methane was available, microbial methane oxidation was limited during both seasons. Measured and averaged rate constants (k') using Michaelis Menten kinetics were on the order of 0.01 days-1, equivalent to a turnover time of 100 days. Time series measurements indicated an uptake of only 5-6% of the gas after 4 days, and no known methanotrophs and pmoA-genes were detected. Estimated methane fluxes indicate that horizontal eddy transport rapidly disperses dissolved methane, vertical transport becomes dominant during phases of high wind speeds, and relative to these processes, microbial methane oxidation appears to be comparably low. To bridge the discrete field data we developed a 1-D seasonal model using available yearlong records of wind speed, surface temperature and thermocline depth. The model simulations show a peak release of methane at the beginning of fall when the water column becomes mixed. Consistent with our field data, inclusion of microbial methane oxidation does not change the model results significantly, thus microbial oxidation appears to be not sufficient to notably reduce methane during summer stratification before the peak release in fall. [ABSTRACT FROM AUTHOR]

Published
2014
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49. A Case of Crohn's Disease with Increased CD8 T-Cell Activation and Remission during Therapy with Intravenous Immunoglobulins.

Author

Körber, J., Köttgen, E., and Renz, H.

Subjects
*CROHN'S disease, *T cells
Abstract

Background: Crohn's disease (CD) represents a chronic inflammatory bowel disease with abnormal CD8 T-cell function in a subgroup of patients. Methods: A 55-year-old woman presented with CD on the basis of clinical, endoscopic, radiologic, histologic, and sonographic examination. Since the disease could not be controlled with conventional anti-inflammatory therapy, a detailed analysis of cellular and humoral immune functions was performed and showed a dysbalanced T-cell activation pattern with an inverse CD4/CD8 ratio due to an increased number of CD8 T cells. Additionally, high IgM and low IgG2 antibody levels were detected. Treatment with intravenous immunoglobulin (IVIG) was started as immunomodulatory therapy. During this therapy the condition improved markedly. CD8 T-cell levels returned to normal, and IgM decreased as well. Conclusion: This case shows that selected cases of CD may be associated with abnormal functions and that such patients may benefit from IVIG treatment. [ABSTRACT FROM AUTHOR]

Published
1998
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50. Ileal and colonic fatty acid profiles in patients with active Crohn's disease.

Author

Bühner, S, Nagel, E, Körber, J, Vogelsang, H, Linn, T, and Pichlmayr, R

Abstract

In patients with active Crohn's disease and in a control group the fatty acid profiles in the whole lipid fraction of ileal and colonic mucosal biopsy specimens were determined by capillary gas chromatography. The biopsy specimens in Crohn's disease patients were taken from the inflamed terminal ileum as well as from the inflamed and macroscopically normal colon. Compared with controls the fatty acid distribution in the inflamed ileal mucosa was significantly characterised by (a) a decrease of 18:2 n6 and 18:3 n3 accompanied by a substantial increase of the highly polyunsaturated fatty acids 20:4 n6, 22:4 n6, and 22:6 n3 and (b) a higher unsaturation index of total fatty acids compared with controls. These changes were similar in the inflamed colon. Additionally, both the inflamed and the macroscopically normal colonic mucosa showed an increase of saturated (18:0) and a decrease of monounsaturated fatty acids (18:1 n9). Fatty acid profiles of ileum and colon showed side variations in controls, but not in the Crohn's disease group. These data suggest that in Crohn's disease changes in the distribution of polyunsaturated fatty acids seem to be the general feature of inflamed mucosa in small and large intestine. Results further suggest that colonic fatty acid metabolism in Crohn's disease is altered by degrees, showing changes in saturated and monounsaturated fatty acids as an additional, primary event. [ABSTRACT FROM PUBLISHER]

Published
1994

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