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This study aims to evaluate the protective efficacy of remifentanil against testicular ischemia-reperfusion injury.The study included 24 male rats. The rats were randomized into three groups: Group 1 was the control group. Group 2 was subjected to a testicular torsion/detorsion model. Group 3 underwent similar procedures and additionally received remifentanil (0.6 μg/kg/min) intravenously for the first 20 min of reperfusion. Blood samples were taken for biochemical analyses, and orchiectomy was performed for histopathologic examination.Biochemical analysis of blood samples showed a significant increase in antioxidant enzyme activity, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in Group 3 compared to Group 2 (p:0.004 and p:0.002, respectively). There was a dramatic decrease in the levels of proinflammatory cytokines, including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:0.001, p:0.046, and p:0.004, respectively). Similarly, malondialdehyde (MDA) levels decreased in Group 3 compared to Group 2 (p:0.004). Histopathologic examination of Group 3 rats showed positive changes in inflammation, hemorrhage, edema, and congestion levels compared to Group 2 (p<0.001). Similarly, there was a positive effect on the Johnsen and Cosentino score in Group 3 compared to Group 2 (p:0.001 and p<0.001, respectively).In our study, it has been documented that remifentanil protects against testicular ischemia-reperfusion injury. [ABSTRACT FROM AUTHOR]

BACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury. METHODS: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflammatory cytokine levels, and antioxidant enzyme activity.Furthermore, histopathological scoring was performed to evaluate tissue damage in the ovaries. RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p<0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p<0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased in Group 3 compared to Group 2 (p=0.031 and p=0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p<0.001, p<0.001, p<0.001, and p=0.001, respectively). CONCLUSION: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histopathological and biochemical outcomes. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of International Journal of Current Medical & Biological Sciences is the property of International Journal of Current Medical & Biological Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Postoperative edema and ecchymosis are frequently observed in rhinoplasty patients. Total intravenous anesthesia and inhalation anesthesia are 2 of the common types of general anesthesia used for rhinoplasty surgery and affect circulation and coagulation. The aim of this study was to investigate the edema and ecchymosis effects of total intravenous anesthesia and inhalation anesthesia in patients undergoing rhinoplasty. Methods: A total of 52 patients undergoing rhinoplasty surgery were enrolled. The patients were divided into 2 groups: total intravenous anesthesia (group T, n = 26) and inhalation anesthesia (group S, n = 26). All patients were photographed by a blinded observer on postoperative days 1, 2, and 7 and were evaluated on a scale ranging from 0 to 4 by 3 independent observers for periorbital edema and ecchymosis. Blood samples were taken from the patients preoperatively and at the second postoperative hour. At the end of the study, edema and ecchymosis of the patients, coagulation, and blood parameters were compared according to the anesthesia type. Results: When rhinoplasty patients in group T and group S were evaluated according to edema and ecchymosis on postoperative days 1, 2, and 7, no statistically significant difference was found (P > .05). There was no difference between the groups in terms of coagulation and blood parameters (P > .05). Conclusion: No difference between total intravenous anesthesia or inhalation anesthesia according to edema and ecchymosis can be seen in the postoperative period in rhinoplasty patients. [ABSTRACT FROM AUTHOR]

Amaç: Akut pankreatit, pankreasın akut enflamasyonudur, lokal ve sistemik komplikasyonlarla seyredebilir. Akut pankreatit ciddi morbidite ve organ yetmezlikleriyle birlikte yüksek mortaliteyle seyreden ciddi bir durumdur, insidansı 300/1 milyon/1 yıldır. Hastane ölümleri genellikle ilk hafta %35-50 oranında gerçekleşir, sebep genellikle tek veya çoklu organ yetmezliğidir. Akut pankreatite bağlı ölümlerin 1/3’ü hastaneye gelmeden kaybedilmekte, bunların hemen hepsine ALI-ARDS eşlik etmektedir. ALI, proteinden zengin eksüdanın alveolar ve interstisyel boşluğa sızmasıyla oksijenasyonun ve gaz değişimin bozulmasına yol açar. ALI’nın ilerlemesiyle ARDS gelişebilir. Pankreatitin sistemik etkisiyle oluşan enflamatuvar yanıtın büyüklüğü klinik seyri ve ALI’nın şiddetini belirler. Akut pankreatitle birlikte gelişen ALI-ARDS, sıklıkla solunum desteğine ihtiyaç gösteren multipl organ disfonksiyon sendromunun (MODS) önemli bir bileşenidir. Olgu: Hastamız 64 yaşında kadın hastaydı. Bilinen hipertansiyonu mevcuttu. Hasta acil servise karın ağrısı, bulantı-kusmayla başvurdu. Hastada hipotansiyon, bilinç bozulması gerçekleşince yoğun bakıma alındı. Yoğun bakıma geldiğinde nöradrenalin (0,16 mcg/kg/dk) desteğiyle tansiyonu: 53/28 mmHg, taşikardik (nabız: 109/dk), takipneik (ss: 36/dk), PO2 /FiO2 (oksijenasyon indeksi): 202 mmHg, nazal 4 lt/dk O2 desteğiyle puls oksimetrede saturasyonu 92 idi. KCFT (ALT-AST) ve BFT (Üre-Kreatinin) değerleri yükselmişti, kan gazı asidotik (Ph: 7,1 LAC: 11 HCO3 : 11,3), APACHE skoru: 35, idrar çıkışı yoktu. Hastada MODS mevcuttu ve hipotansif şoktaydı. Hastaya sağlanan sıvı replasman hızı ve inotrop desteği artırıldı. Kültürleri (kan-idrar) alındı, ampirik antibiyotik (meropenem) başlandı. Hastaya triflo başlandı. İdrar çıkışı 15 saat sonra gözlenmeye başlandı, idrar çıkışı olmasına rağmen 6. gününe kadar BFT yükselmeye devam etti ve 6 günden sonra BFT gerilemeye başladı. Hastanın 4. gün O2 (oksijen) ihtiyacı arttı, 5. gün akciğer grafisinde bilateral infiltrasyon gözlendi, Toraks BT’de buzlu cam alanları mevcut, PaO2 /FiO2 : 60 mmHg idi. Hastanın ARDS tablosu mevcuttu. Hasta izole edildi, COVID ekartasyonu amacıyla günaşırı COVID testi yapıldı. Hastanın oksijen ihtiyacı 7 günden sonra azalmaya başladı, inotrop desteği azaltılarak 7. günde stoplandı. Akciğer grafisinde infiltrasyonun gerilemesi, COVID testlerinin negatif gelmesiyle beraber hasta yoğun bakım yatışının 9. günü servise sağlıkla eksterne edildi. Sonuç: Bu olguda COVID pandemisinde akciğerlerdeki buzlu cam manzarası ilk planda COVID pnömonisi düşündürse de pankreatite sekonder olarak ARDS olabileceğini ve primer hastalığın gerilemesiyle akciğer infiltrasyonunun düzeldiğini gözlemledik. [ABSTRACT FROM AUTHOR]

Background: This experimental study aimed to evaluate the potential protective effects of lidocaine on ischemia-reperfusion injury resulting from testicular torsion/detorsion in rats., Methods: A total of 18 male rats were randomized into three groups. Group 1 served as the control group. Group 2 was designed to evaluate testicular ischemia-reperfusion injury using a torsion/detorsion model. In Group 3, the treatment group, a similar ischemia-reperfusion model was used as in Group 2. Additionally, lidocaine at a dose of 15 mg/kg was administered intraperitoneally five minutes before reperfusion. Blood biochemical analyses and testicular histopathological evaluations were conducted., Results: Blood biochemical analysis showed that malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly higher in Group 2 compared to the other groups (p<0.001 and p=0.008, respectively). Proinflammatory cytokine levels, including interleu-kin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), were lower in Group 3 than in Group 2 (p<0.001, p=0.007, and p=0.026, respectively). Antioxidant enzyme activities, including glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.005 and p=0.025, respectively). Histopathological evaluations revealed significant improvements in all testicular damage scores, including hemorrhage, edema, vasocongestion, and inflammation in Group 3 compared to Group 2 (p=0.015, p=0.035, p=0.015, and p=0.034, respectively). Additionally, there was a notable improvement in the Johnsen score in Group 3 compared to Group 2 (p=0.034)., Conclusion: Lidocaine, an effective local anesthetic, significantly alleviates the effects of testicular ischemia-reperfusion injury.

Background: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury., Methods: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflammatory cytokine levels, and antioxidant enzyme activity RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p<0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p<0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased in Group 3 compared to Group 2 (p=0.031 and p=0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p<0.001, p<0.001, p<0.001, and p=0.001, respectively)., Conclusion: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histopathological and biochemical outcomes.

Background: This study aimed to evaluate the histopathological and biochemical effects of ketamine on penile tissues following ischemia-reperfusion injury induced by priapism., Methods: Twenty-four male rats were randomized into three groups. Group 1 served as the control group. Group 2 underwent the priapism model to induce ischemia-reperfusion injury. Group 3, the treatment group, experienced a similar ischemia-reperfusion model as Group 2; additionally, 50 mg/kg of ketamine was administered intraperitoneally just before reperfusion. Blood biochemical analyses and penile histopathological evaluations were performed., Results: In Group 3, significant improvements were observed in all histopathological scores, including desquamation, edema, inflammation, and vasocongestion compared to Group 2 (p<0.001). Blood biochemical analyses showed that the malondialdehyde (MDA) levels were recorded as 10 in Group 2, with a significant decrease in Group 3 (p=0.013). Similarly, proinflammatory cytokine levels, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were found to be suppressed in Group 3 compared to Group 2 (p=0.003, p=0.022, and p=0.028, respectively). Antioxidant enzyme activities, such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.016 and p=0.024, respec-tively)., Conclusion: Ketamine is an effective anesthetic agent in alleviating the effects of penile ischemia-reperfusion injury.