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2. Appendices

Author

Oswald, Alfred, Köhler, Jens, Schmitt, Roland, Oswald, Alfred, Köhler, Jens, and Schmitt, Roland

Published
2018
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7. Drill Milling

Author

Köhler, Jens, O'Donnell, Garret, Section editor, Chatti, Sami, editor, Laperrière, Luc, editor, Reinhart, Gunther, editor, and Tolio, Tullio, editor

Published
2019
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8. Grinding Parameters

Author

Köhler, Jens, Wegener, Konrad, Section editor, Chatti, Sami, editor, Laperrière, Luc, editor, Reinhart, Gunther, editor, and Tolio, Tullio, editor

Published
2019
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9. Cutting Edge Geometry

Author

Köhler, Jens, O'Donnell, Garret, Section editor, Chatti, Sami, editor, Laperrière, Luc, editor, Reinhart, Gunther, editor, and Tolio, Tullio, editor

Published
2019
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15. Anhänge

Author

Oswald, Alfred, Köhler, Jens, Schmitt, Roland, Oswald, Alfred, Köhler, Jens, and Schmitt, Roland

Published
2017
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18. Comprehensive genomic profiles of small cell lung cancer

Author

George, Julie, Lim, Jing Shan, Jang, Se Jin, Cun, Yupeng, Ozretić, Luka, Kong, Gu, Leenders, Frauke, Lu, Xin, Fernández-Cuesta, Lynnette, Bosco, Graziella, Müller, Christian, Dahmen, Ilona, Jahchan, Nadine S, Park, Kwon-Sik, Yang, Dian, Karnezis, Anthony N, Vaka, Dedeepya, Torres, Angela, Wang, Maia Segura, Korbel, Jan O, Menon, Roopika, Chun, Sung-Min, Kim, Deokhoon, Wilkerson, Matt, Hayes, Neil, Engelmann, David, Pützer, Brigitte, Bos, Marc, Michels, Sebastian, Vlasic, Ignacija, Seidel, Danila, Pinther, Berit, Schaub, Philipp, Becker, Christian, Altmüller, Janine, Yokota, Jun, Kohno, Takashi, Iwakawa, Reika, Tsuta, Koji, Noguchi, Masayuki, Muley, Thomas, Hoffmann, Hans, Schnabel, Philipp A, Petersen, Iver, Chen, Yuan, Soltermann, Alex, Tischler, Verena, Choi, Chang-min, Kim, Yong-Hee, Massion, Pierre P, Zou, Yong, Jovanovic, Dragana, Kontic, Milica, Wright, Gavin M, Russell, Prudence A, Solomon, Benjamin, Koch, Ina, Lindner, Michael, Muscarella, Lucia A, la Torre, Annamaria, Field, John K, Jakopovic, Marko, Knezevic, Jelena, Castaños-Vélez, Esmeralda, Roz, Luca, Pastorino, Ugo, Brustugun, Odd-Terje, Lund-Iversen, Marius, Thunnissen, Erik, Köhler, Jens, Schuler, Martin, Botling, Johan, Sandelin, Martin, Sanchez-Cespedes, Montserrat, Salvesen, Helga B, Achter, Viktor, Lang, Ulrich, Bogus, Magdalena, Schneider, Peter M, Zander, Thomas, Ansén, Sascha, Hallek, Michael, Wolf, Jürgen, Vingron, Martin, Yatabe, Yasushi, Travis, William D, Nürnberg, Peter, Reinhardt, Christian, Perner, Sven, Heukamp, Lukas, Büttner, Reinhard, Haas, Stefan A, Brambilla, Elisabeth, Peifer, Martin, Sage, Julien, and Thomas, Roman K

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Human Genome, Cancer, Rare Diseases, Lung, Lung Cancer, Aetiology, 2.1 Biological and endogenous factors, Alleles, Animals, Cell Line, Tumor, Chromosome Breakpoints, Cyclin D1, DNA-Binding Proteins, Disease Models, Animal, Female, Gene Expression Profiling, Genome, Human, Genomics, Humans, Lung Neoplasms, Male, Mice, Mutation, Neurosecretory Systems, Nuclear Proteins, Receptors, Notch, Retinoblastoma Protein, Signal Transduction, Small Cell Lung Carcinoma, Tumor Protein p73, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, General Science & Technology
Abstract

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Δex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.

Published
2015

21. Anhänge

Author

Oswald, Alfred, Köhler, Jens, Schmitt, Roland, Oswald, Alfred, Köhler, Jens, and Schmitt, Roland

Published
2016
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38. Index Optimization for L-Diversified Database-as-a-Service

Author

Köhler, Jens, Hartenstein, Hannes, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Garcia-Alfaro, Joaquin, editor, Herrera-Joancomartí, Jordi, editor, Lupu, Emil, editor, Posegga, Joachim, editor, Aldini, Alessandro, editor, Martinelli, Fabio, editor, and Suri, Neeraj, editor

Published
2015
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40. Data from Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

Author

Bahcall, Magda, primary, Paweletz, Cloud P., primary, Kuang, Yanan, primary, Taus, Luke J., primary, Sim, Taebo, primary, Kim, Nam Doo, primary, Dholakia, Kshiti H., primary, Lau, Christie J., primary, Gokhale, Prafulla C., primary, Chopade, Pratik R., primary, Hong, Fangxin, primary, Wei, Zihan, primary, Köhler, Jens, primary, Kirschmeier, Paul T., primary, Guo, Jiannan, primary, Guo, Sujuan, primary, Wang, Stephen, primary, and Jänne, Pasi A., primary

Published
2023
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41. Supplementary Data from Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

Author

Bahcall, Magda, primary, Paweletz, Cloud P., primary, Kuang, Yanan, primary, Taus, Luke J., primary, Sim, Taebo, primary, Kim, Nam Doo, primary, Dholakia, Kshiti H., primary, Lau, Christie J., primary, Gokhale, Prafulla C., primary, Chopade, Pratik R., primary, Hong, Fangxin, primary, Wei, Zihan, primary, Köhler, Jens, primary, Kirschmeier, Paul T., primary, Guo, Jiannan, primary, Guo, Sujuan, primary, Wang, Stephen, primary, and Jänne, Pasi A., primary

Published
2023
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42. Supplementary Materials and Methods from Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

Author

Bahcall, Magda, primary, Paweletz, Cloud P., primary, Kuang, Yanan, primary, Taus, Luke J., primary, Sim, Taebo, primary, Kim, Nam Doo, primary, Dholakia, Kshiti H., primary, Lau, Christie J., primary, Gokhale, Prafulla C., primary, Chopade, Pratik R., primary, Hong, Fangxin, primary, Wei, Zihan, primary, Köhler, Jens, primary, Kirschmeier, Paul T., primary, Guo, Jiannan, primary, Guo, Sujuan, primary, Wang, Stephen, primary, and Jänne, Pasi A., primary

Published
2023
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43. Supplementary Table 2 from EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Author

Haikala, Heidi M., primary, Lopez, Timothy, primary, Köhler, Jens, primary, Eser, Pinar O., primary, Xu, Man, primary, Zeng, Qing, primary, Teceno, Tyler J., primary, Ngo, Kenneth, primary, Zhao, Yutong, primary, Ivanova, Elena V., primary, Bertram, Arrien A., primary, Leeper, Brittaney A., primary, Chambers, Emily S., primary, Adeni, Anika E., primary, Taus, Luke J., primary, Kuraguchi, Mari, primary, Kirschmeier, Paul T., primary, Yu, Channing, primary, Shiose, Yoshinobu, primary, Kamai, Yasuki, primary, Qiu, Yang, primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, and Jänne, Pasi A., primary

Published
2023
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44. Supplementary Table 3 from EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Author

Haikala, Heidi M., primary, Lopez, Timothy, primary, Köhler, Jens, primary, Eser, Pinar O., primary, Xu, Man, primary, Zeng, Qing, primary, Teceno, Tyler J., primary, Ngo, Kenneth, primary, Zhao, Yutong, primary, Ivanova, Elena V., primary, Bertram, Arrien A., primary, Leeper, Brittaney A., primary, Chambers, Emily S., primary, Adeni, Anika E., primary, Taus, Luke J., primary, Kuraguchi, Mari, primary, Kirschmeier, Paul T., primary, Yu, Channing, primary, Shiose, Yoshinobu, primary, Kamai, Yasuki, primary, Qiu, Yang, primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, and Jänne, Pasi A., primary

Published
2023
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45. Supplementary Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer

Author

Ricciuti, Biagio, primary, Son, Jieun, primary, Okoro, Jeffrey J., primary, Mira, Alessia, primary, Patrucco, Enrico, primary, Eum, Yoonji, primary, Wang, Xinan, primary, Paranal, Raymond, primary, Wang, Haiyun, primary, Lin, Mika, primary, Haikala, Heidi M., primary, Li, Jiaqi, primary, Xu, Yue, primary, Alessi, Joao Victor, primary, Chhoeu, Chhayheng, primary, Redig, Amanda J., primary, Köhler, Jens, primary, Dholakia, Kshiti H., primary, Chen, Yunhan, primary, Richard, Elodie, primary, Nokin, Marie-Julie, primary, Santamaria, David, primary, Gokhale, Prafulla C., primary, Awad, Mark M., primary, Jänne, Pasi A., primary, and Ambrogio, Chiara, primary

Published
2023
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46. Data from EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Author

Haikala, Heidi M., primary, Lopez, Timothy, primary, Köhler, Jens, primary, Eser, Pinar O., primary, Xu, Man, primary, Zeng, Qing, primary, Teceno, Tyler J., primary, Ngo, Kenneth, primary, Zhao, Yutong, primary, Ivanova, Elena V., primary, Bertram, Arrien A., primary, Leeper, Brittaney A., primary, Chambers, Emily S., primary, Adeni, Anika E., primary, Taus, Luke J., primary, Kuraguchi, Mari, primary, Kirschmeier, Paul T., primary, Yu, Channing, primary, Shiose, Yoshinobu, primary, Kamai, Yasuki, primary, Qiu, Yang, primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, and Jänne, Pasi A., primary

Published
2023
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47. Supplementary Table 1 from EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Author

Haikala, Heidi M., primary, Lopez, Timothy, primary, Köhler, Jens, primary, Eser, Pinar O., primary, Xu, Man, primary, Zeng, Qing, primary, Teceno, Tyler J., primary, Ngo, Kenneth, primary, Zhao, Yutong, primary, Ivanova, Elena V., primary, Bertram, Arrien A., primary, Leeper, Brittaney A., primary, Chambers, Emily S., primary, Adeni, Anika E., primary, Taus, Luke J., primary, Kuraguchi, Mari, primary, Kirschmeier, Paul T., primary, Yu, Channing, primary, Shiose, Yoshinobu, primary, Kamai, Yasuki, primary, Qiu, Yang, primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, and Jänne, Pasi A., primary

Published
2023
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48. Supplementary Data from EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Author

Haikala, Heidi M., primary, Lopez, Timothy, primary, Köhler, Jens, primary, Eser, Pinar O., primary, Xu, Man, primary, Zeng, Qing, primary, Teceno, Tyler J., primary, Ngo, Kenneth, primary, Zhao, Yutong, primary, Ivanova, Elena V., primary, Bertram, Arrien A., primary, Leeper, Brittaney A., primary, Chambers, Emily S., primary, Adeni, Anika E., primary, Taus, Luke J., primary, Kuraguchi, Mari, primary, Kirschmeier, Paul T., primary, Yu, Channing, primary, Shiose, Yoshinobu, primary, Kamai, Yasuki, primary, Qiu, Yang, primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, and Jänne, Pasi A., primary

Published
2023
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50. Abrahamitiska religioner i svenska läromedel, 1994-2020 : Hur religionerna skildras gentemot varandra

Author

Köhler, Jens, Istrefi, Drilon, Köhler, Jens, and Istrefi, Drilon

Abstract

I svenska läromedel för religionskunskap på högstadienivå är det vanligt att de “abrahamitiska religionerna” behandlas för att ge eleverna en ökad förståelse för religiös mångfald och främja interreligiös tolerans. Tyvärr finns det dock tendenser där islam och judendom framställs som "den andre" i förhållande till kristendomen. Denna framställning varierar beroende på författare och förlag, vilket kan leda till att negativa betoningar får större utrymme i böckerna då skillnader lättare uppmärksammas än likheterna mellan de tre religionerna. Som en följd kan eleverna få en förenklad och stereotypisk bild av religionernas innehåll, historia och praktik. Eftersom kristendom ofta framställs som den samhälleliga normen, blir judendom och islam ofta jämförda i omfång och innehåll, vilket leder till att de hamnar i en position som "den andre" och oftast blir offer för stereotypiseringar och förenklingar. Ibland kan islam porträtteras och tolkas som “bakåtsträvande” och “sexitiskt” då författarna medvetet fokuserar på kontroversiella aspekter som kvinnoförtryck, utan att ge en djupare bild av religionens historiska helhet. Detta kan skapa en ensidig och negativ bild av islam i klassrummet och förstärka fördomar och missuppfattningar som redan finns i samhället. På samma sätt förminskas judendom till att handla enbart om historiska händelser som Förintelsen och den israeliska staten, vilket inte rättvist representerar religionen och det judiska folket. Detta kan förstärka uppfattningen om judendomen som stagnant och gammalmodig, samtidigt som dess många nyanser ignoreras. För att undvika att porträttera islam och judendom som “den andre” i kontrast till kristendom är det viktigt att läromedel ger en rättvis och balanserad bild av de “abrahamitiska religionerna” i deras helhet. Det bör betonas att alla religioner har många olika tolkningar och utövare runt om i världen, och det är därför viktigt att undvika generaliseringar och stereotyper. Genom att presentera religionerna p

Published
2023

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