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304 results on '"Kälsch, Hagen"'

1. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

Author

Malhotra, Rajeev, Mauer, Andreas C, Lino Cardenas, Christian L, Guo, Xiuqing, Yao, Jie, Zhang, Xiaoling, Wunderer, Florian, Smith, Albert V, Wong, Quenna, Pechlivanis, Sonali, Hwang, Shih-Jen, Wang, Judy, Lu, Lingyi, Nicholson, Christopher J, Shelton, Georgia, Buswell, Mary D, Barnes, Hanna J, Sigurslid, Haakon H, Slocum, Charles, Rourke, Caitlin O’, Rhee, David K, Bagchi, Aranya, Nigwekar, Sagar U, Buys, Emmanuel S, Campbell, Catherine Y, Harris, Tamara, Budoff, Matthew, Criqui, Michael H, Rotter, Jerome I, Johnson, Andrew D, Song, Ci, Franceschini, Nora, Debette, Stephanie, Hoffmann, Udo, Kälsch, Hagen, Nöthen, Markus M, Sigurdsson, Sigurdur, Freedman, Barry I, Bowden, Donald W, Jöckel, Karl-Heinz, Moebus, Susanne, Erbel, Raimund, Feitosa, Mary F, Gudnason, Vilmundur, Thanassoulis, George, Zapol, Warren M, Lindsay, Mark E, Bloch, Donald B, Post, Wendy S, and O’Donnell, Christopher J

Subjects
Biological Sciences, Genetics, Human Genome, Heart Disease - Coronary Heart Disease, Heart Disease, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Aged, Animals, Aorta, Atherosclerosis, Cohort Studies, Female, GTPase-Activating Proteins, Genetic Predisposition to Disease, Genome-Wide Association Study, Histone Deacetylases, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Muscle Contraction, Muscle, Smooth, Vascular, Phenotype, Polymorphism, Single Nucleotide, Repressor Proteins, Vascular Calcification, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P

Published
2019

3. Associations between aspirin and other non-steroidal anti-inflammatory drugs and aortic valve or coronary artery calcification: The Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study

Author

Delaney, Joseph A, Lehmann, Nils, Jöckel, Karl-Heinz, Elmariah, Sammy, Psaty, Bruce M, Mahabadi, Amir A, Budoff, Matt, Kronmal, Richard A, Nasir, Khurram, O’Brien, Kevin D, Möhlenkamp, Stefan, Moebus, Susanne, Dragano, Nico, Winterstein, Almut G, Erbel, Raimund, and Kälsch, Hagen

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular, Aging, Prevention, Clinical Research, Atherosclerosis, Heart Disease, Heart Disease - Coronary Heart Disease, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Aortic Valve Stenosis, Aspirin, Calcinosis, Cohort Studies, Coronary Artery Disease, Cyclooxygenase 2 Inhibitors, Female, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Prevalence, Regression Analysis, Risk Factors, Tomography, X-Ray Computed, Non-steroidal anti-inflammatory drugs, Aortic valve calcification, Coronary artery calcification, Multi-Ethnic Study of Atherosclerosis, Heinz Nixdorf Recall Study, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundThe association between non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence of valvular and arterial calcification is not well established despite known associations between these drugs and cardiovascular events.ObjectiveTo compare the association between the baseline use of aspirin with other NSAID class medications with the incidence and prevalence of aortic valve calcification (AVC) and coronary artery calcification (CAC).MethodsThe relationship of NSAID use to AVC and CAC detected by computed tomography was assessed in 6814 participants within the Multi-Ethnic Study of Atherosclerosis (MESA) using regression modeling. Results were adjusted for age, sex, ethnicity, study site, anti-hypertensive medication use, education, income, health insurance status, diabetes, smoking, exercise, body mass index, blood pressure, serum lipids, inflammatory markers, fasting glucose, statin medication use, and a simple diet score. Medication use was assessed by medication inventory at baseline which includes the use of non-prescription NSAIDs. MESA collects information on both incident and prevalent calcification. The 4814 participants of the Heinz Nixdorf Recall (HNR) Study, a German prospective cohort study with similar measures of calcification, were included in this analysis to enable replication.ResultsMean age of the MESA participants was 62 years (51% female). After adjustment for possible confounding factors, a possible association between aspirin use and incident AVC (Relative Risk(RR): 1.60; 95%Confidence Interval (CI): 1.19-2.15) did not replicate in the HNR cohort (RR: 1.06; 95%CI: 0.87-1.28). There was no significant association between aspirin use and incident CAC in the MESA cohort (RR 1.08; 95%CI: 0.91-1.29) or in the HNR cohort (RR 1.24; 95%CI: 0.87-1.77). Non-aspirin NSAID use was not associated with either AVC or CAC in either cohort. There were no associations between regular cardiac dose aspirin and incident calcification in either cohort.ConclusionBaseline NSAID use, as assessed by medication inventory, appears to have no protective effect regarding the onset of calcification in either coronary arteries or aortic valves.

Published
2013

7. Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

Author

Wolf, Kathrin, Stafoggia, Massimo, Cesaroni, Giulia, Andersen, Zorana Jovanovic, Beelen, Rob, Galassi, Claudia, Hennig, Frauke, Migliore, Enrica, Penell, Johanna, Ricceri, Fulvio, Sørensen, Mette, Turunen, Anu W., Hampel, Regina, Hoffmann, Barbara, Kälsch, Hagen, Laatikainen, Tiina, Pershagen, Göran, Raaschou-Nielsen, Ole, Sacerdote, Carlotta, Vineis, Paolo, Badaloni, Chiara, Cyrys, Josef, de Hoogh, Kees, Eriksen, Kirsten T., Jedynsk, Aleksandra, Keuken, Menno, Kooter, Ingeborg, Lanki, Timo, Ranzi, Andrea, Sugiri, Dorothea, Tsai, Ming-Yi, Wang, Meng, Hoek, Gerard, Brunekreef, Bert, Peters, Annette, and Forastiere, Francesco

Published
2015

9. Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events: Result of the HNR Study (Heinz Nixdorf Recall)

Author

Lehmann, Nils, Erbel, Raimund, Mahabadi, Amir A., Rauwolf, Michael, Möhlenkamp, Stefan, Moebus, Susanne, Kälsch, Hagen, Budde, Thomas, Schmermund, Axel, Stang, Andreas, Führer-Sakel, Dagmar, Weimar, Christian, Roggenbuck, Ulla, Dragano, Nico, Jöckel, Karl-Heinz, Meinertz, T., Bode, C., de Feyter, P.J., Güntert, B., Gutzwiller, F., Heinen, H., Hess, O., Klein, B., Löwel, H., Reiser, M., Schmidt, G., Schwaiger, M., Steinmüller, C., Theorell, T., Willich, S.N., Bode, C., Berger, K., Figulla, H.R., Hamm, C., Hanrath, P., Köpcke, W., Ringelstein, B., Dichgans, M., and Zeiher, A.

Published
2018
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19. Association of progressive thoracic aortic calcification with future cardiovascular events and all-cause mortality: ability to improve risk prediction? Results of the Heinz Nixdorf Recall (HNR) study

Author

Kälsch, Hagen, Mahabadi, Amir Abbas, Moebus, Susanne, Reinsch, Nico, Budde, Thomas, Hoffmann, Barbara, Stang, Andreas, Jöckel, Karl-Heinz, Erbel, Raimund, Lehmann, Nils, and on behalf of the Heinz Nixdorf Recall Study Investigators

Subjects
Male, medicine.medical_specialty, Computed Tomography Angiography, medicine.medical_treatment, Population, Aortic Diseases, Medizin, Aorta, Thoracic, Coronary Disease, 030204 cardiovascular system & hematology, Revascularization, Risk Assessment, Severity of Illness Index, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Cause of Death, Germany, medicine.artery, Internal medicine, Humans, Medicine, Thoracic aorta, Radiology, Nuclear Medicine and imaging, Prospective Studies, Myocardial infarction, Vascular Calcification, education, Aged, education.field_of_study, business.industry, Proportional hazards model, Hazard ratio, General Medicine, Middle Aged, medicine.disease, Confidence interval, Survival Rate, stomatognathic diseases, Cohort, Disease Progression, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Thoracic aortic calcification (TAC) is measured by computed tomography (CT). We investigated the association of TAC-progression with incident cardiovascular (CV) events and all-cause mortality in a population-based cohort and to determine its predictive value for these endpoints. Methods and results In 3080 participants (45-74 years, 53.6% women), risk factors and TAC via CT were measured at baseline and at a second examination after 5.1 ± 0.3 years. Hard coronary, hard CV events as well as CV events including revascularization and all-cause mortality were recorded during a follow-up time of 7.8 ± 2.2 years after the second CT scan. Cox regression analysis determined the association of TAC-progression with observed endpoints. The predictive value of TAC-progression was assessed using Harrell's C index. We observed 81 hard coronary, 154 hard CV, 231 CV events including revascularization, and 266 deaths. In the crude analysis, event rates increased continuously with the level of TAC-change over 5 years for all endpoints. After adjustment, the significant association of TAC-progression with hard CV events [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.05-1.57] and all-cause mortality (HR 1.34, 95% CI 1.14-1.58) persisted, per one standard deviation increase in TAC-progression (log(TAC + 1)). Regarding aortic segments separately, HRs were consistently higher for descending thoracic aorta. When adding TAC (baseline and progression) to the model containing classical risk factors and coronary artery calcification (CAC), Harrell's C indices did not increase for any of the observed endpoints. Conclusion TAC-progression is associated with incident hard CV events and all-cause mortality but fails to improve event prediction over CAC.

Published
2018

20. Prevalence of thoracic aortic calcification and its relationship to cardiovascular risk factors and coronary calcification in an unselected population-based cohort: the Heinz Nixdorf Recall Study

Author

Kälsch, Hagen, Lehmann, Nils, Möhlenkamp, Stefan, Hammer, Cornelia, Mahabadi, Amir A., Moebus, Susanne, Schmermund, Axel, Stang, Andreas, Bauer, Marcus, Jöckel, Karl-Heinz, Erbel, Raimund, and On behalf of the Investigator Group of the Heinz Nixdorf Recall Study

Published
2013
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22. Progression of coronary artery calcification seems to be inevitable, but predictable - results of the Heinz Nixdorf Recall (HNR) study†

Author

Erbel, Raimund, Lehmann, Nils, Churzidse, Sofia, Rauwolf, Michael, Mahabadi, Amir A., Möhlenkamp, Stefan, Moebus, Susanne, Bauer, Marcus, Kälsch, Hagen, Budde, Thomas, Montag, Michael, Schmermund, Axel, Stang, Andreas, Führer-Sakel, Dagmar, Weimar, Christian, Roggenbuck, Ulla, Dragano, Nico, and Jöckel, Karl-Heinz

Published
2014
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28. Association of exercise capacity and the heart rate profile during exercise stress testing with subclinical coronary atherosclerosis: data from the Heinz Nixdorf Recall study

Author

Möhlenkamp, Stefan, Lehmann, Nils, Schmermund, Axel, Roggenbuck, Ulla, Moebus, Susanne, Dragano, Nico, Bauer, Marcus, Kälsch, Hagen, Hoffmann, Barbara, Stang, Andreas, Bröcker-Preuss, Martina, Böhm, Michael, Mann, Klaus, Jöckel, Karl-Heinz, Erbel, Raimund, and on behalf of the Heinz Nixdorf Recall Study Investigators

Published
2009
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29. Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study

Author

Kälsch, Hagen, Hennig, Frauke, Moebus, Susanne, Möhlenkamp, Stefan, Dragano, Nico, Jakobs, Hermann, Memmesheimer, Michael, Erbel, Raimund, Jöckel, Karl-Heinz, Hoffmann, Barbara, Roggenbuck, U., Slomiany, U., Beck, E. M., Öffner, A., Münkel, S., Schrader, S., Peter, R., Hirche, H., Meinertz, T., Bode, C., deFeyter, P.J., Güntert, B., Halli, T., Gutzwiller, F., Heinen, H., Hess, O., Klein, B., Löwel, H., Reiser, M., Schmidt, G., Schwaiger, M., Steinmüller, C., Theorell, T., and Willich, S.N.

Published
2014
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32. Analyse des natürlichen Verlaufs der Koronargefäßverkalkung und Identifizierung ihrer Determinanten: Rationale des 2. Teils der Heinz Nixdorf Recall Studie

Author

Möhlenkamp, Stefan, Moebus, Susanne, Schmermund, Axel, Lehmann, Nils, Hoffmann, Barbara, Neumann, Till, Stang, Andreas, Dragano, Nico, Kerkhoff, Gert, Naber, Christoph, Kälsch, Hagen, Beck, Eva-Maria, Bröcker-Preuss, Martina, Kröger, Knut, Budde, Thomas, Siegrist, Johannes, Mann, Klaus, Jöckel, Karl-Heinz, Erbel, Raimund, and für die Studiengruppe der Heinz Nixdorf Recall Studie

Published
2007
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34. Genetic Associations with Valvular Calcification and Aortic Stenosis

Author

Thanassoulis, George, Campbell, Catherine Y., Owens, David S., Smith, J. Gustav, Smith, Albert V., Peloso, Gina M., Kerr, Kathleen F., Pechlivanis, Sonali, Budoff, Matthew J., Harris, Tamara B., Malhotra, Rajeev, OʼBrien, Kevin D., Kamstrup, Pia R., Nordestgaard, Børge G., Tybjaerg-Hansen, Anne, Allison, Matthew A., Aspelund, Thor, Criqui, Michael H., Heckbert, Susan R., Hwang, Shih-Jen, Liu, Yongmei, Sjogren, Marketa, van der Pals, Jesper, Kälsch, Hagen, Mühleisen, Thomas W., Nöthen, Markus M., Cupples, L. Adrienne, Caslake, Muriel, Di Angelantonio, Emanuele, Danesh, John, Rotter, Jerome I., Sigurdsson, Sigurdur, Wong, Quenna, Erbel, Raimund, Kathiresan, Sekar, Melander, Olle, Gudnason, Vilmundur, OʼDonnell, Christopher J., and Post, Wendy S.

Published
2013
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39. Value of progression of coronary artery calcification for risk prediction of coronary and cardiovascular events

Author

Lehmann, Nils, Erbel, Raimund, Mahabadi, Amir Abbas, Rauwolf, Michael, Möhlenkamp, Stefan, Moebus, Susanne, Kälsch, Hagen, Budde, Thomas, Schmermund, Axel, Stang, Andreas, Führer-Sakel, Dagmar, Weimar, Christian, Roggenbuck, Ulla, Dragano, Nico, Jöckel, Karl-Heinz, and Heinz Nixdorf Recall Study Investigators

Subjects
ddc:610
Abstract

Background: Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction of coronary and cardiovascular events. Methods: In 3281 participants (45–74 years of age), free from cardiovascular disease until the second visit, risk factors, and CTs at baseline (b) and after a mean of 5.1 years (5y) were measured. Hard coronary and cardiovascular events, and total cardiovascular events including revascularization, as well, were recorded during a follow-up time of 7.8±2.2 years after the second CT. The added predictive value of 10 CAC progression algorithms on top of risk factors including baseline CAC was evaluated by using survival analysis, C-statistics, net reclassification improvement, and integrated discrimination index. A subgroup analysis of risk in CAC categories was performed. Results: We observed 85 (2.6%) hard coronary, 161 (4.9%) hard cardiovascular, and 241 (7.3%) total cardiovascular events. Absolute CAC progression was higher with versus without subsequent coronary events (median, 115 [Q1–Q3, 23–360] versus 8 [0–83], P5 years after the first scan may be of additional value, except when a double-zero CT scan is present or when the subjects are already at high risk.

Published
2018

41. Value of progression of coronary artery calcification for risk prediction of coronary and cardiovascular events

Author

Heinz Nixdorf Recall Study Investigators, Lehmann, Nils, Erbel, Raimund, Mahabadi, Amir Abbas, Rauwolf, Michael, Möhlenkamp, Stefan, Moebus, Susanne, Kälsch, Hagen, Budde, Thomas, Schmermund, Axel, Stang, Andreas, Führer-Sakel, Dagmar, Weimar, Christian, Roggenbuck, Ulla, Dragano, Nico, Jöckel, Karl-Heinz, Heinz Nixdorf Recall Study Investigators, Lehmann, Nils, Erbel, Raimund, Mahabadi, Amir Abbas, Rauwolf, Michael, Möhlenkamp, Stefan, Moebus, Susanne, Kälsch, Hagen, Budde, Thomas, Schmermund, Axel, Stang, Andreas, Führer-Sakel, Dagmar, Weimar, Christian, Roggenbuck, Ulla, Dragano, Nico, and Jöckel, Karl-Heinz

Abstract

Background: Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction of coronary and cardiovascular events. Methods: In 3281 participants (45–74 years of age), free from cardiovascular disease until the second visit, risk factors, and CTs at baseline (b) and after a mean of 5.1 years (5y) were measured. Hard coronary and cardiovascular events, and total cardiovascular events including revascularization, as well, were recorded during a follow-up time of 7.8±2.2 years after the second CT. The added predictive value of 10 CAC progression algorithms on top of risk factors including baseline CAC was evaluated by using survival analysis, C-statistics, net reclassification improvement, and integrated discrimination index. A subgroup analysis of risk in CAC categories was performed. Results: We observed 85 (2.6%) hard coronary, 161 (4.9%) hard cardiovascular, and 241 (7.3%) total cardiovascular events. Absolute CAC progression was higher with versus without subsequent coronary events (median, 115 [Q1–Q3, 23–360] versus 8 [0–83], P<0.0001; similar for hard/total cardiovascular events). Some progression algorithms added to the predictive value of baseline CT and risk assessment in terms of C-statistic or integrated discrimination index, especially for total cardiovascular events. However, CAC progression did not improve models including CAC5y and 5-year risk factors. An excellent prognosis was found for 921 participants with double-zero CACb=CAC5y=0 (10-year coronary and hard/total cardiovascular risk: 1.4%, 2.0%, and 2.8%), which was for participants with incident CAC 1.8%, 3.8%, and 6.6%, respectively. When CACb progressed from 1 to 399 to CAC5y≥400, coronary and total cardiovascular risk were nearly 2-fold in comparison with subjects who remained below CAC5y=400. Participants with CACb≥400 had high rates of hard coronary and hard/total

Published
2018

43. Air Pollution and Progression of Atherosclerosis in Different Vessel Beds-Results from a Prospective Cohort Study in the Ruhr Area, Germany.

Author

Hennig, Frauke, Geisel, Marie Henrike, Kälsch, Hagen, Lucht, Sarah, Mahabadi, Amir Abbas, Moebus, Susanne, Erbel, Raimund, Lehmann, Nils, Jöckel, Karl-Heinz, Scherag, André, Hoffmann, Barbara, and Heinz Nixdorf Recall Study Investigative Group

Subjects
AIR pollution, ATHEROSCLEROSIS, DISEASE progression
Abstract

OBJECTIVES: Due to inconsistent epidemiological evidence on health effects of air pollution on progression of atherosclerosis, we investigated several air pollutants and their effects on progression of atherosclerosis, using carotid intima media thickness (cIMT), coronary calcification (CAC), and thoracic aortic calcification (TAC). METHODS: We used baseline (2000-2003) and 5-y follow-up (2006-2008) data from the German Heinz Nixdorf Recall cohort study, including 4,814 middle-aged adults. Residence-based long-term air pollution exposure, including particulate matter (PM) with aerodynamic diameter ≤2.5 μm (PM2.5), (PM10), and nitrogen dioxide (NO2) was assessed using chemistry transport and land use regression (LUR) models. cIMT was quantified as side-specific median IMT assessed from standardized ultrasound images. CAC and TAC were quantified by computed tomography using the Agatston score. Development (yes/no) and progression of atherosclerosis (change in cIMT and annual growth rate for CAC/TAC) were analyzed with logistic and linear regression models, adjusting for age, sex, lifestyle variables, socioeconomic status, and traffic noise. RESULTS: While no clear associations were observed in the full study sample (mean age 59.1 (±7:6) y; 53% female), most air pollutants were marginally associated with progression of atherosclerosis in participants with no or low baseline atherosclerotic burden. Most consistently for CAC, e.g., a 1.5 μg/m³ higher exposure to PM2.5 (LUR) yielded an estimated odds ratio of 1.19 [95% confidence interval (CI): 1.03, 1.39] for progression of CAC and an increased annual growth rate of 2% (95% CI: 1%, 4%). CONCLUSION: Our study suggests that development and progression of subclinical atherosclerosis is associated with long-term air pollution in middle-aged participants with no or minor atherosclerotic burden at baseline, while overall no consistent associations are observed. [ABSTRACT FROM AUTHOR]

Published
2020
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