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3. Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics

Author

Kananen, Laura, Hurme, Mikko, Bürkle, Alexander, Moreno-Villanueva, Maria, Bernhardt, Jürgen, Debacq-Chainiaux, Florence, Grubeck-Loebenstein, Beatrix, Malavolta, Marco, Basso, Andrea, Piacenza, Francesco, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Jansen, Eugene H. J. M., Dollé, Martijn E. T., Salmon, Michel, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Capri, Miriam, Franceschi, Claudio, Slagboom, Eline, Talbot, Duncan, Libert, Claude, Raitanen, Jani, Koskinen, Seppo, Härkänen, Tommi, Stenholm, Sari, Ala-Korpela, Mika, Lehtimäki, Terho, Raitakari, Olli T., Ukkola, Olavi, Kähönen, Mika, Jylhä, Marja, and Jylhävä, Juulia

Published
2023
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6. A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Author

Deelen, Joris, Evans, Daniel S, Arking, Dan E, Tesi, Niccolò, Nygaard, Marianne, Liu, Xiaomin, Wojczynski, Mary K, Biggs, Mary L, van der Spek, Ashley, Atzmon, Gil, Ware, Erin B, Sarnowski, Chloé, Smith, Albert V, Seppälä, Ilkka, Cordell, Heather J, Dose, Janina, Amin, Najaf, Arnold, Alice M, Ayers, Kristin L, Barzilai, Nir, Becker, Elizabeth J, Beekman, Marian, Blanché, Hélène, Christensen, Kaare, Christiansen, Lene, Collerton, Joanna C, Cubaynes, Sarah, Cummings, Steven R, Davies, Karen, Debrabant, Birgit, Deleuze, Jean-François, Duncan, Rachel, Faul, Jessica D, Franceschi, Claudio, Galan, Pilar, Gudnason, Vilmundur, Harris, Tamara B, Huisman, Martijn, Hurme, Mikko A, Jagger, Carol, Jansen, Iris, Jylhä, Marja, Kähönen, Mika, Karasik, David, Kardia, Sharon LR, Kingston, Andrew, Kirkwood, Thomas BL, Launer, Lenore J, Lehtimäki, Terho, Lieb, Wolfgang, Lyytikäinen, Leo-Pekka, Martin-Ruiz, Carmen, Min, Junxia, Nebel, Almut, Newman, Anne B, Nie, Chao, Nohr, Ellen A, Orwoll, Eric S, Perls, Thomas T, Province, Michael A, Psaty, Bruce M, Raitakari, Olli T, Reinders, Marcel JT, Robine, Jean-Marie, Rotter, Jerome I, Sebastiani, Paola, Smith, Jennifer, Sørensen, Thorkild IA, Taylor, Kent D, Uitterlinden, André G, van der Flier, Wiesje, van der Lee, Sven J, van Duijn, Cornelia M, van Heemst, Diana, Vaupel, James W, Weir, David, Ye, Kenny, Zeng, Yi, Zheng, Wanlin, Holstege, Henne, Kiel, Douglas P, Lunetta, Kathryn L, Slagboom, P Eline, and Murabito, Joanne M

Subjects
Humans, Heat-Shock Proteins, Longevity, Apolipoprotein E2, Apolipoprotein E4, Genome-Wide Association Study
Abstract

Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.

Published
2019

12. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Author

Deelen, Joris, Evans, Daniel S., Arking, Dan E., Tesi, Niccolò, Nygaard, Marianne, Liu, Xiaomin, Wojczynski, Mary K., Biggs, Mary L., van der Spek, Ashley, Atzmon, Gil, Ware, Erin B., Sarnowski, Chloé, Smith, Albert V., Seppälä, Ilkka, Cordell, Heather J., Dose, Janina, Amin, Najaf, Arnold, Alice M., Ayers, Kristin L., Barzilai, Nir, Becker, Elizabeth J., Beekman, Marian, Blanché, Hélène, Christensen, Kaare, Christiansen, Lene, Collerton, Joanna C., Cubaynes, Sarah, Cummings, Steven R., Davies, Karen, Debrabant, Birgit, Deleuze, Jean-François, Duncan, Rachel, Faul, Jessica D., Franceschi, Claudio, Galan, Pilar, Gudnason, Vilmundur, Harris, Tamara B., Huisman, Martijn, Hurme, Mikko A., Jagger, Carol, Jansen, Iris, Jylhä, Marja, Kähönen, Mika, Karasik, David, Kardia, Sharon L. R., Kingston, Andrew, Kirkwood, Thomas B. L., Launer, Lenore J., Lehtimäki, Terho, Lieb, Wolfgang, Lyytikäinen, Leo-Pekka, Martin-Ruiz, Carmen, Min, Junxia, Nebel, Almut, Newman, Anne B., Nie, Chao, Nohr, Ellen A., Orwoll, Eric S., Perls, Thomas T., Province, Michael A., Psaty, Bruce M., Raitakari, Olli T., Reinders, Marcel J. T., Robine, Jean-Marie, Rotter, Jerome I., Sebastiani, Paola, Smith, Jennifer, Sørensen, Thorkild I. A., Taylor, Kent D., Uitterlinden, André G., van der Flier, Wiesje, van der Lee, Sven J., van Duijn, Cornelia M., van Heemst, Diana, Vaupel, James W., Weir, David, Ye, Kenny, Zeng, Yi, Zheng, Wanlin, Holstege, Henne, Kiel, Douglas P., Lunetta, Kathryn L., Slagboom, P. Eline, and Murabito, Joanne M.

Published
2021
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33. Dementia and Related Comorbidities in the Population Aged 90 and Over in the Vitality 90+ Study, Finland: Patterns and Trends From 2001 to 2018.

Author

Halonen, Pauliina, Enroth, Linda, Jämsen, Esa, Vargese, Saritha, and Jylhä, Marja

Subjects
HYPERTENSION epidemiology, NONAGENARIANS, DIABETES, DEMENTIA, DESCRIPTIVE statistics, DISEASE prevalence, OSTEOARTHRITIS, MENTAL depression, RESEARCH funding, LOGISTIC regression analysis, COMORBIDITY, SECONDARY analysis, OLD age
Abstract

Objectives: To examine trends in the prevalence of dementia and related comorbidities among the oldest old. Methods: Six repeated cross-sectional surveys were conducted between 2001 and 2018, each including all inhabitants aged over 90 in Tampere, Finland (n = 5386). Co-occurring conditions and their time trends among participants with dementia were examined using logistic regression and generalized estimating equations. Results: The prevalence of dementia decreased from 47% in 2007 to 41% in 2018. Throughout the study period, depression was more common among people with dementia compared to those without. The prevalence of hypertension, diabetes, and osteoarthritis increased and the prevalence of depression decreased among people with dementia. The mean number of comorbidities increased from 2.0 in 2001 to 2.3 in 2018. Discussion: Dementia remains highly prevalent among the oldest old and it is accompanied by an increasing burden of comorbidities, posing a challenge to people with dementia, their caregivers, and care systems. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics

Author

Kananen, Laura, primary, Hurme, Mikko, additional, Bürkle, Alexander, additional, Moreno-Villanueva, Maria, additional, Bernhardt, Jürgen, additional, Debacq-Chainiaux, Florence, additional, Grubeck-Loebenstein, Beatrix, additional, Malavolta, Marco, additional, Basso, Andrea, additional, Piacenza, Francesco, additional, Collino, Sebastiano, additional, Gonos, Efstathios S., additional, Sikora, Ewa, additional, Gradinaru, Daniela, additional, Jansen, Eugene H. J. M., additional, Dollé, Martijn E. T., additional, Salmon, Michel, additional, Stuetz, Wolfgang, additional, Weber, Daniela, additional, Grune, Tilman, additional, Breusing, Nicolle, additional, Simm, Andreas, additional, Capri, Miriam, additional, Franceschi, Claudio, additional, Slagboom, Eline, additional, Talbot, Duncan, additional, Libert, Claude, additional, Raitanen, Jani, additional, Koskinen, Seppo, additional, Härkänen, Tommi, additional, Stenholm, Sari, additional, Ala-Korpela, Mika, additional, Lehtimäki, Terho, additional, Raitakari, Olli T., additional, Ukkola, Olavi, additional, Kähönen, Mika, additional, Jylhä, Marja, additional, and Jylhävä, Juulia, additional

Published
2022
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46. Supplemental Material - Dementia and Related Comorbidities in the Population Aged 90 and Over in the Vitality 90+ Study, Finland: Patterns and Trends From 2001 to 2018

Author

Halonen, Pauliina, Enroth, Linda, Jämsen, Esa, Vargese, Saritha, and Jylhä, Marja

Subjects
FOS: Clinical medicine, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology
Abstract

Supplemental Material for Dementia and Related Comorbidities in the Population Aged 90 and Over in the Vitality 90+ Study, Finland: Patterns and Trends From 2001 to 2018 by Pauliina Halonen, Linda Enroth, Esa Jämsen, Saritha Vargese, and Marja Jylhä in Journal of Aging and Health

Published
2022
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47. Family's role in long‐term care : A qualitative study of Finnish family members' experiences on supporting the functional ability of an older relative

Author

Lehto-Niskala, Vilhelmiina, Jolanki, Outi, Jylhä, Marja, Tampere University, and Health Sciences

Subjects
functional ability, perheenjäsenet, pitkäaikaishoito, residential care, nursing homes, 3142 Public health care science, environmental and occupational health, 3141 Health care science, family care, older people, toimintakyky, perhesuhteet, long-term care, hoitokodit, ikääntyneet
Abstract

Family members are important providers of care for older people. In residential long-term care, however, their role is not always simple and straightforward: responsibility for care provision rests officially with staff members, but in practice family members often contribute to providing care. The main reason for admission to long-term care is functional decline. At the same time, the maintenance of functional ability is a central goal in long-term care. It is therefore reasonable to assume that functional ability is also an important factor in the relationship between family members and long-term care residents. This study aims to explore how family members experience their role in supporting the functional ability of older relatives in residential long-term care. With the approval of the local hospital district's ethics committee, we conducted semi-structured interviews with family members (n = 16) in Finland in 2016. Thematic data analysis showed that family members supported the functional ability of their older parent or spouse by organising and monitoring care and by bringing forth their relative's personal needs and wishes. They often saw their role alongside staff members as ambiguous, and their understanding of the scope of support for functioning extended beyond physical everyday tasks. In their talk, family members broadened the concept of functional ability from daily chores and independence to meaningful social relations and acknowledgement of person's individual background and preferences. Family members’ views offer valuable insights into residents’ personal needs, values and preferences and in doing so help care workers to support their functional ability with a person-centred care approach. publishedVersion

Published
2022

48. Mikä muuttui vai muuttuiko mikään? : Yli 65-vuotiaiden arki korona-aikana

Author

Ahosola, Päivi, Tuominen, Katariina, Tiainen, Kristina, Jylhä, Marja, Jolanki, Outi, Tampere University, and Terveystieteet

Subjects
3141 Terveystiede
Abstract

The COVID-19 pandemic has proved to be most dangerous for older people, and therefore the restrictions and recommendations to avoid social contact have concerned them more than other age groups. In this article, we examine how the pandemic has affected older people’s lives and well-being. Our data come from telephone interviews with 31 people (aged 64–96) conducted during summer 2020. The data were analysed using content analysis. Our results show that the period of restrictions imposed during the pandemic affected the lives of older people in many different ways. Many felt that their everyday lives had remained the same or changed only a little. Some felt that their lives had become worse, and some that they had become better. For many interviewees, life before the pandemic had been so challenging, and social contact so rare, that the pandemic restrictions did not make their situation any worse. Many had developed innovative new ways to behave safely, and this enabled them to continue their everyday lives almost unchanged. The built environment, such as walkways and green spaces, had become more important for well-being. Connecting with other people by telephone was also important for well-being. However, new technologies to support meetings online played no significant role, except for the few interviewees who were familiar with them. Older people were fairly adaptive and flexible in their everyday lives, and their life experience influenced their ability to face various challenges during the pandemic. publishedVersion

Published
2021

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