1. Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep
- Author
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Juliana Benavides-Lara, Rayyan Manwar, Laura S. McGuire, Md. Tarikul Islam, Anthony Shoo, Fady T. Charbel, Martha G. Menchaca, Amanda P. Siegel, De-Ann M. Pillers, Juri G. Gelovani, and Kamran Avanaki
- Subjects
Transfontanelle ,Photoacoustic imaging ,Neonates ,PVH ,IVH ,Periventricular hemorrhage ,Physics ,QC1-999 ,Acoustics. Sound ,QC221-246 ,Optics. Light ,QC350-467 - Abstract
Intraventricular (IVH) and periventricular (PVH) hemorrhages in preterm neonates are common because the periventricular blood vessels are still developing up to 36 weeks and are fragile. Currently, transfontanelle ultrasound (US) imaging is utilized for screening for IVH and PVH, largely through the anterior fontanelle. However for mild hemorrhages, inconclusive diagnoses are common, leading to failure to detect IVH/PVH or, when other clinical symptoms are present, use of second stage neuroimaging modalities requiring transport of vulnerable patients. Yet even mild IVH/PVH increases the risk of moderate-severe neurodevelopmental impairment. Here, we demonstrate the capability of transfontanelle photoacoustic imaging (TFPAI) to detect IVH and PVH in-vivo in a large animal model. TFPAI was able to detect IVH/PVH as small as 0.3 mL in volume in the brain (p
- Published
- 2023
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