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2. Estrogen upregulates renal angiotensin II A[T.sub.2] receptors

Author

Armando, Ines, Jezova, Miroslava, Juorio, Augusto V., Terron, Jose A., Falcon-Neri, Alicia, Semino-Mora, Cristina, Imboden, Hans, and Saavedra, Juan M.

Subjects
Estrogen -- Research, Angiotensin -- Research, Nucleotides -- Research, Prostaglandins -- Research, Biological sciences
Abstract

A[T.sub.2] receptors may act in opposition to and in balance with A[T.sub.1] receptors, their stimulation having beneficial effects. We found renal A[T.sub.2] receptor expression in female mice higher than in male mice. We asked the question of whether such expression might be estrogen dependent. In male, female, ovariectomized, and estrogentreated ovariectomized mice, we studied renal A[T.sub.1] and A[T.sub.2] receptors by immunocytochemistry and autoradiography, A[T.sub.2] receptor mRNA by RT-PCR, and cAMP, cGMP, and PG[E.sub.2] by RIA. A[T.sub.1] receptors predominated. A[T.sub.2] receptors were present in glomeruli, medullary rays, and inner medulla, and in female kidney capsule. A[T.sub.1] and A[T.sub.2] receptors colocalized in glomeruli. Female mice expressed fewer glomerular A[T.sub.1] receptors. Ovariectomy decreased A[T.sub.1] receptors in medullary rays and capsular A[T.sub.2] receptors. Estrogen administration normalized A[T.sub.1] receptors in medullary rays and increased A[T.sub.2] receptors predominantly in capsule and inner medulla, and also in glomeruli, medullary rays, and inner stripe of outer medulla. In medullas of estrogen-treated ovariectomized mice there was higher A[T.sub.2] receptor mRNA, decreased cGMP, and increased PG[E.sub.2] content. We propose that the protective effects of estrogen may be partially mediated through enhancement of A[T.sub.2] receptor stimulation. renin-angiotensin system; reproductive hormones; kidney function; cyclic nucleotides; prostaglandins

Published
2002

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