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1. LongITools:dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author

Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), Sebert, S. (Sylvain), Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), and Sebert, S. (Sylvain)

Abstract

The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our ”modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.

Published
2022

2. Psychiatric research in the Northern Finland Birth Cohort 1986:a systematic review

Author

Miettunen, J. (Jouko), Haapea, M. (Marianne), Björnholm, L. (Lassi), Huhtaniska, S. (Sanna), Juola, T. (Teija), Kinnunen, L. (Lotta), Lehtiniemi, H. (Heli), Lieslehto, J. (Johannes), Rautio, N. (Nina), and Nordström, T. (Tanja)

Subjects
systematic review, psychosis risk, emotional problems, ADHD, birth cohort, behavioural problems
Abstract

The Northern Finland Birth Cohort 1986 is a large population-based birth cohort, which aims to promote health and wellbeing of the population. In this paper, we systematically review the psychiatric research performed in the cohort until today, i.e. at the age of 32 years of the cohort (2018). We conducted a systematic literature search using the databases of PubMed and Scopus and complemented it with a manual search. We found a total of 94 articles, which were classified as examining ADHD, emotional and behavioural problems, psychosis risk or other studies relating to psychiatric subjects. The articles are mainly based on two large comprehensive follow-up studies of the cohort and several substudies. The studies have often used also nationwide register data. The studies have found several early predictors for the aforementioned psychiatric outcomes, such as problems at pregnancy and birth, family factors in childhood, physical inactivity and substance use in adolescence. There are also novel findings relating to brain imaging and cognition, for instance regarding familial risk of psychosis in relation to resting state functional MRI. The Northern Finland Birth Cohort 1986 has been utilised frequently in psychiatric research and future data collections are likely to lead to new scientifically important findings.

Published
2019

3. Cohort Profile: The DynaHEALTH consortium - A European consortium for a life-course bio-psychosocial model of healthy ageing of glucose homeostasis

Author

Sebert, S. (Sylvain), Lowry, E. (Estelle), Aumüller, N. (Nicole), Bermúdez, M.G. (Mercedes G.), Bjerregaard, L.G. (Lise G.), Rooij, S.R. (Susanne) de, De Silva, M. (Maneka), El Marroun, H. (Hanan), Hummel, N. (Nadine), Juola, T. (Teija), Mason, G. (Giacomo), Much, D. (D), Oliveros, E. (Elena), Poupakis, S. (Stavros), Rautio, N. (Nina), Schwarzfischer, P. (Phillipp), Tzala, E. (Evangelia), Uhl, O. (Olaf), Van De Beek, C. (Cornelieke), Vehmeijer, F.O.L. (Florianne O.L.), Verdejo-Román, J. (Juan), Wasenius, N. (Niko), Webster, C. (Claire), Ala-Mursula, L. (Leena), Herzig, K.H., Keinanen-Kiukaanniemi, S. (Sirkka), Miettunen, J. (Jouko), Baker, J.L. (Jennifer L.), Campoy, C. (Cristina), Conti, G. (Gabriella), Hagen, K. (Knut), Hummel, S. (Sandra), Jaddoe, V.W.V. (Vincent), Koletzko, B. (Berthold), Lewin, A. (Alex), Rodriguez-Palermo, M. (Maria), Roseboom, T.J. (Tessa), Rueda, R. (Ricardo), Evans, J. (Jonathan Mark), Felix, J.F. (Janine), Prokopenko, I. (Inga), Sørensen, T.I.A. (Thorkild I. A.), Järvelin, M.-R. (Marjo-Riitta), Sebert, S. (Sylvain), Lowry, E. (Estelle), Aumüller, N. (Nicole), Bermúdez, M.G. (Mercedes G.), Bjerregaard, L.G. (Lise G.), Rooij, S.R. (Susanne) de, De Silva, M. (Maneka), El Marroun, H. (Hanan), Hummel, N. (Nadine), Juola, T. (Teija), Mason, G. (Giacomo), Much, D. (D), Oliveros, E. (Elena), Poupakis, S. (Stavros), Rautio, N. (Nina), Schwarzfischer, P. (Phillipp), Tzala, E. (Evangelia), Uhl, O. (Olaf), Van De Beek, C. (Cornelieke), Vehmeijer, F.O.L. (Florianne O.L.), Verdejo-Román, J. (Juan), Wasenius, N. (Niko), Webster, C. (Claire), Ala-Mursula, L. (Leena), Herzig, K.H., Keinanen-Kiukaanniemi, S. (Sirkka), Miettunen, J. (Jouko), Baker, J.L. (Jennifer L.), Campoy, C. (Cristina), Conti, G. (Gabriella), Hagen, K. (Knut), Hummel, S. (Sandra), Jaddoe, V.W.V. (Vincent), Koletzko, B. (Berthold), Lewin, A. (Alex), Rodriguez-Palermo, M. (Maria), Roseboom, T.J. (Tessa), Rueda, R. (Ricardo), Evans, J. (Jonathan Mark), Felix, J.F. (Janine), Prokopenko, I. (Inga), Sørensen, T.I.A. (Thorkild I. A.), and Järvelin, M.-R. (Marjo-Riitta)

Published
2019
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4. Cohort profile:the DynaHEALTH consortium – a European consortium for a life-course bio-psychosocial model of healthy ageing of glucose homeostasis

Author

Sebert, S. (Sylvain), Lowry, E. (Estelle), Aumüller, N. (Nicole), Bermúdez, M. G. (Mercedes G), Bjerregaard, L. G. (Lise G), de Rooij, S. R. (Susanne R), De Silva, M. (Maneka), El Marroun, H. (Hanan), Hummel, N. (Nadine), Juola, T. (Teija), Mason, G. (Giacomo), Much, D. (Daniela), Oliveros, E. (Elena), Poupakis, S. (Stavros), Rautio, N. (Nina), Schwarzfischer, P. (Phillipp), Tzala, E. (Evangelia), Uhl, O. (Olaf), van de Beek, C. (Cornelieke), Vehmeijer, F. (Florianne), Verdejo-Román, J. (Juan), Wasenius, N. (Niko), Webster, C. (Claire), Ala-Mursula, L. (Leena), Herzig, K.-H. (Karl-Heinz), Keinänen-Kiukaanniemi, S. (Sirkka), Miettunen, J. (Jouko), Baker, J. L. (Jennifer L), Campoy, C. (Cristina), Conti, G. (Gabriella), Eriksson, J. G. (Johan G), Hummel, S. (Sandra), Jaddoe, V. (Vincent), Koletzko, B. (Berthold), Lewin, A. (Alex), Rodriguez-Palermo, M. (Maria), Roseboom, T. (Tessa), Rueda, R. (Ricardo), Evans, J. (Jayne), Felix, J. F. (Janine F), Prokopenko, I. (Inga), Sørensen, T. I. (Thorkild IA), Järvelin, M.-R. (Marjo-Riitta), Sebert, S. (Sylvain), Lowry, E. (Estelle), Aumüller, N. (Nicole), Bermúdez, M. G. (Mercedes G), Bjerregaard, L. G. (Lise G), de Rooij, S. R. (Susanne R), De Silva, M. (Maneka), El Marroun, H. (Hanan), Hummel, N. (Nadine), Juola, T. (Teija), Mason, G. (Giacomo), Much, D. (Daniela), Oliveros, E. (Elena), Poupakis, S. (Stavros), Rautio, N. (Nina), Schwarzfischer, P. (Phillipp), Tzala, E. (Evangelia), Uhl, O. (Olaf), van de Beek, C. (Cornelieke), Vehmeijer, F. (Florianne), Verdejo-Román, J. (Juan), Wasenius, N. (Niko), Webster, C. (Claire), Ala-Mursula, L. (Leena), Herzig, K.-H. (Karl-Heinz), Keinänen-Kiukaanniemi, S. (Sirkka), Miettunen, J. (Jouko), Baker, J. L. (Jennifer L), Campoy, C. (Cristina), Conti, G. (Gabriella), Eriksson, J. G. (Johan G), Hummel, S. (Sandra), Jaddoe, V. (Vincent), Koletzko, B. (Berthold), Lewin, A. (Alex), Rodriguez-Palermo, M. (Maria), Roseboom, T. (Tessa), Rueda, R. (Ricardo), Evans, J. (Jayne), Felix, J. F. (Janine F), Prokopenko, I. (Inga), Sørensen, T. I. (Thorkild IA), and Järvelin, M.-R. (Marjo-Riitta)

Published
2019

5. Epidemiology of psychotic depression:systematic review and meta-analysis

Author

Jääskeläinen, E. (E.), Juola, T. (T.), Korpela, H. (H.), Lehtiniemi, H. (H.), Nietola, M. (M.), Korkeila, J. (J.), and Miettunen, J. (J.)

Abstract

Large amount of data have been published on non-psychotic depression (NPD), schizophrenia (SZ), and bipolar disorder, while psychotic depression (PD) as an own entity has received much smaller attention. We performed a systematic review and meta-analyses on epidemiology, especially incidence and prevalence, risk factors, and outcomes of PD. A systematic search to identify potentially relevant studies was conducted using four electronic databases and a manual search. The search identified 1764 unique potentially relevant articles, the final study included 99 articles. We found that the lifetime prevalence of PD varies between 0.35% and 1%, with higher rates in older age. Onset age of PD was earlier than that of NPD in younger samples, but later in older samples. There were no differences in gender distribution in PD v. NPD, but higher proportion of females was found in PD than in SZ or in psychotic bipolar disorder (PBD). Risk factors have rarely been studied, the main finding being that family history of psychosis and bipolar disorder increases the risk of PD. Outcomes of PD were mostly worse when compared with NPD, but better compared with SZ and schizoaffective disorder. The outcome compared with PBD was relatively similar, and somewhat varied depending on the measure of the outcome. Based on this review, the amount of research on PD is far from that of NPD, SZ, and bipolar disorder. Based on our findings, PD seems distinguishable from related disorders and needs more scientific attention.

Published
2018

7. Epidemiology of psychotic depression – systematic review and meta-analysis.

Author

Jääskeläinen, E., Juola, T., Korpela, H., Lehtiniemi, H., Nietola, M., Korkeila, J., and Miettunen, J.

Subjects
*MENTAL depression risk factors, *AGE distribution, *AGE factors in disease, *BIPOLAR disorder, *MENTAL depression, *META-analysis, *PSYCHOSES, *SCHIZOPHRENIA, *SEX distribution, *SYSTEMATIC reviews, *FAMILY history (Medicine), *PROGNOSIS, PSYCHOSES risk factors
Abstract

Large amount of data have been published on non-psychotic depression (NPD), schizophrenia (SZ), and bipolar disorder, while psychotic depression (PD) as an own entity has received much smaller attention. We performed a systematic review and meta-analyses on epidemiology, especially incidence and prevalence, risk factors, and outcomes of PD. A systematic search to identify potentially relevant studies was conducted using four electronic databases and a manual search. The search identified 1764 unique potentially relevant articles, the final study included 99 articles. We found that the lifetime prevalence of PD varies between 0.35% and 1%, with higher rates in older age. Onset age of PD was earlier than that of NPD in younger samples, but later in older samples. There were no differences in gender distribution in PD v. NPD, but higher proportion of females was found in PD than in SZ or in psychotic bipolar disorder (PBD). Risk factors have rarely been studied, the main finding being that family history of psychosis and bipolar disorder increases the risk of PD. Outcomes of PD were mostly worse when compared with NPD, but better compared with SZ and schizoaffective disorder. The outcome compared with PBD was relatively similar, and somewhat varied depending on the measure of the outcome. Based on this review, the amount of research on PD is far from that of NPD, SZ, and bipolar disorder. Based on our findings, PD seems distinguishable from related disorders and needs more scientific attention. [ABSTRACT FROM AUTHOR]

Published
2018
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8. LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases.

Author

Ronkainen J, Nedelec R, Atehortua A, Balkhiyarova Z, Cascarano A, Ngoc Dang V, Elhakeem A, van Enckevort E, Goncalves Soares A, Haakma S, Halonen M, Heil KF, Heiskala A, Hyde E, Jacquemin B, Keikkala E, Kerckhoffs J, Klåvus A, Kopinska JA, Lepeule J, Marazzi F, Motoc I, Näätänen M, Ribbenstedt A, Rundblad A, Savolainen O, Simonetti V, de Toro Eadie N, Tzala E, Ulrich A, Wright T, Zarei I, d'Amico E, Belotti F, Brunius C, Castleton C, Charles MA, Gaillard R, Hanhineva K, Hoek G, Holven KB, Jaddoe VWV, Kaakinen MA, Kajantie E, Kavousi M, Lakka T, Matthews J, Piano Mortari A, Vääräsmäki M, Voortman T, Webster C, Zins M, Atella V, Bulgheroni M, Chadeau-Hyam M, Conti G, Evans J, Felix JF, Heude B, Järvelin MR, Kolehmainen M, Landberg R, Lekadir K, Parusso S, Prokopenko I, de Rooij SR, Roseboom T, Swertz M, Timpson N, Ulven SM, Vermeulen R, Juola T, and Sebert S

Abstract

The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our "modern" postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases., Competing Interests: The authors declare no conflict of interest.The authors declare that they have no conflicts of interest with regard to the content of this report., (Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.)

Published
2021
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9. Psychiatric research in the Northern Finland Birth Cohort 1986 - a systematic review.

Author

Miettunen J, Haapea M, Björnholm L, Huhtaniska S, Juola T, Kinnunen L, Lehtiniemi H, Lieslehto J, Rautio N, and Nordström T

Subjects
Adolescent, Adolescent Behavior, Adult, Arctic Regions epidemiology, Attention Deficit Disorder with Hyperactivity epidemiology, Child, Child Behavior Disorders epidemiology, Child, Preschool, Finland epidemiology, Humans, Infant, Mental Disorders diagnostic imaging, Risk Factors, Socioeconomic Factors, Substance-Related Disorders epidemiology, Young Adult, Mental Disorders epidemiology, Mental Health statistics & numerical data
Abstract

The Northern Finland Birth Cohort 1986 is a large population-based birth cohort, which aims to promote health and wellbeing of the population. In this paper, we systematically review the psychiatric research performed in the cohort until today, i.e. at the age of 32 years of the cohort (2018). We conducted a systematic literature search using the databases of PubMed and Scopus and complemented it with a manual search. We found a total of 94 articles, which were classified as examining ADHD, emotional and behavioural problems, psychosis risk or other studies relating to psychiatric subjects. The articles are mainly based on two large comprehensive follow-up studies of the cohort and several substudies. The studies have often used also nationwide register data. The studies have found several early predictors for the aforementioned psychiatric outcomes, such as problems at pregnancy and birth, family factors in childhood, physical inactivity and substance use in adolescence. There are also novel findings relating to brain imaging and cognition, for instance regarding familial risk of psychosis in relation to resting state functional MRI. The Northern Finland Birth Cohort 1986 has been utilised frequently in psychiatric research and future data collections are likely to lead to new scientifically important findings. Abbreviations: attention deficit hyperactivity disorder (ADHD); magnetic resonance imaging (MRI).

Published
2019
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10. Cohort Profile: The DynaHEALTH consortium - a European consortium for a life-course bio-psychosocial model of healthy ageing of glucose homeostasis.

Author

Sebert S, Lowry E, Aumüller N, Bermúdez MG, Bjerregaard LG, de Rooij SR, De Silva M, El Marroun H, Hummel N, Juola T, Mason G, Much D, Oliveros E, Poupakis S, Rautio N, Schwarzfischer P, Tzala E, Uhl O, van de Beek C, Vehmeijer F, Verdejo-Román J, Wasenius N, Webster C, Ala-Mursula L, Herzig KH, Keinänen-Kiukaanniemi S, Miettunen J, Baker JL, Campoy C, Conti G, Eriksson JG, Hummel S, Jaddoe V, Koletzko B, Lewin A, Rodriguez-Palermo M, Roseboom T, Rueda R, Evans J, Felix JF, Prokopenko I, Sørensen TIA, and Järvelin MR

Subjects
Blood Glucose physiology, Cardiovascular Diseases genetics, Cardiovascular Diseases prevention & control, Causality, Dementia epidemiology, Dementia genetics, Diabetes Mellitus, Type 2 genetics, Diabetes Mellitus, Type 2 prevention & control, Europe epidemiology, Health Status, Humans, Life Style, Longitudinal Studies, Mental Health, Obesity genetics, Obesity prevention & control, Socioeconomic Factors, Aging physiology, Cardiovascular Diseases epidemiology, Diabetes Mellitus, Type 2 epidemiology, Health Behavior, Healthy Aging psychology, Obesity epidemiology
Published
2019
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