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Abstract Virtual walking systems for stationary observers have been developed using multimodal stimulation such as vision, touch, and sound to overcome physical limitation. In previous studies, participants were typically positioned in either a standing or a seated position. It would be beneficial if bedridden users could have enough virtual walking experience. Thus, we aimed to investigate the effects of participants’ posture and foot vibrations on the experience of virtual walking. They were either sitting, standing, or lying during observing a virtual scene of a walking avatar in the first-person perspective, while vibrations either synchronized or asynchronized (randomized) to the avatar’s walking were applied to their feet. We found that the synchronized foot vibrations improved virtual walking experiences compared to asynchronous vibrations. The standing position consistently offered an improved virtual walking experience compared to sitting and lying positions with either the synchronous or asynchronous foot vibrations, while the difference between the siting and lying postures was small and not significant. Furthermore, subjective scores for posture matching between real and virtual postures, illusory body ownership, and sense of agency were significantly higher with the synchronous than the asynchronous vibration. These findings suggest that experiencing virtual walking with foot vibrations in a lying position is less effective than a standing position, but not much different from a sitting position.

Abstract Background Older adults are more likely to experience loneliness than younger people. Moreover, greater loneliness in older adults is associated with poor mental health and increased risk of cardiovascular disease and mortality. Physical activity is an effective intervention for reducing loneliness among older adults. Among physical activities, walking is suitable for older adults, because it is easy and safe to incorporate into daily life. We hypothesized that the association between walking and loneliness depends on the presence of others and the number of people present. The aim of this study is to investigate the association between the context of walking (the number of walkers) and loneliness among community-dwelling older adults. Methods This cross-sectional study included 173 community-dwelling older adults aged 65 or older. Context of walking was classified as non-walking, walking alone (days of walking alone > days of walking with someone), and walking with someone (days of walking alone ≤ days of walking with someone). Loneliness was measured using the Japanese version of the University of California Los Angeles Loneliness Scale. A linear regression model was used to investigate the relationship between context of walking and loneliness, adjusted for age, sex, living situation, social participation, and physical activity excluding walking. Results Data from 171 community-dwelling older adults (mean age = 78.0 years, 59.6% women) were analyzed. After adjustment, walking with someone was associated with lower loneliness than non-walking (adjusted β: -0.51, 95% confidence interval: -1.00, -0.01). Conclusions The study’s findings suggest that walking with a companion may effectively prevent or reduce loneliness among older adults.

Human locomotion is most naturally achieved through walking, which is good for both mental and physical health. To provide a virtual walking experience to seated users, a system utilizing foot vibrations and simulated optical flow was developed. The current study sought to augment this system and examine the effect of an avatar's cast shadow and foot vibrations on the virtual walking experience and cybersickness. The omnidirectional movie and the avatar's walking animation were synchronized, with the cast shadow reflecting the avatar's movement on the ground. Twenty participants were exposed to the virtual walking in six conditions (with/without foot vibrations and no/short/long shadow) and were asked to rate their sense of telepresence, walking experience, and occurrences of cybersickness. Our findings indicate that the synchronized foot vibrations enhanced telepresence as well as self-motion, walking, and leg-action sensations, while also reducing instances of nausea and disorientation sickness. The avatar's cast shadow was found to improve telepresence and leg-action sensation, but had no impact on self-motion and walking sensation. These results suggest that observation of the self-body cast shadow does not directly improve walking sensation, but is effective in enhancing telepresence and leg-action sensation, while foot vibrations are effective in improving telepresence and walking experience and reducing instances of cybersickness.

Allergic bronchopulmonary aspergillosis (ABPA) is an allergic reaction caused by the fungus Aspergillus, and it is often treated with steroids or antifungal agents. However, long-term use of these medications can lead to infections and drug interactions. We present the case of a 71-year-old woman with ABPA who was diagnosed with hepatitis B and active hepatitis C, and sputum analysis revealed the presence of bacteria. Oral steroids were initially administered, but the patient was switched to mepolizumab because of numerous infectious complications. The early introduction of mepolizumab is effective in patients with ABPA complicated by infectious diseases.

Background: The standard of care for unresectable, locally advanced non-small-cell lung cancer (LA-NSCLC) is chemoradiotherapy (CRT) followed by durvalumab, based on the PACIFIC study. Although multiple Japanese phase II studies have shown high efficacy and tolerability of CRT with cisplatin plus S-1 (SP), no prospective study using durvalumab after SP-based CRT has been reported. Objectives: We conducted a multicenter phase II study of this approach, the interim analysis of which showed a high transition rate to durvalumab consolidation therapy. Here, we report the primary analysis results. Design: In treatment-naïve LA-NSCLC, cisplatin (60 mg/m 2 , day 1) and S-1 (80–120 mg/body, days 1–14) were administered with two 4-week cycles with concurrent thoracic radiotherapy (60 Gy) followed by durvalumab (10 mg/kg) every 2 weeks for up to 1 year. Methods: The primary endpoint was 1-year progression-free survival (PFS). The expected 1-year PFS and its lower limit of the 80% confidence interval (CI) were set as 63% and 47%, respectively, based on the results of TORG1018 study. Results: In all, 59 patients were enrolled, with 51 (86.4%) proceeding to durvalumab. The objective response rate throughout the study was 72.9% (95% CI: 59.7–83.6%). After median follow-up of 21.9 months, neither median PFS nor OS was reached. The 1-year PFS was 72.5% (80% CI: 64.2–79.2%, 95% CI: 59.1–82.2%), while the 1-year overall survival was 91.5% (95% CI: 80.8–96.4%). No grade 5 adverse events were observed throughout the study. The most common adverse event during the consolidation phase was pneumonitis (any grade, 78.4%; grade ⩾3, 2.0%). Eventually, 52.5% of patients completed 1-year durvalumab consolidation therapy from CRT initiation. Conclusion: This study of durvalumab after SP-based CRT met its primary endpoint and found a 1-year PFS of 73% from CRT initiation. This study provides the first prospective data on the prognosis and tolerability of durvalumab consolidation from the initiation of CRT. Trial registration: Japan Registry of Clinical Trials, jRCTs031190127, registered 1 November, 2019, https://jrct.niph.go.jp/latest-detail/jRCTs031190127

Background: The standard of care for unresectable, locally advanced non-small cell lung cancer (LA-NSCLC) is chemoradiotherapy (CRT) followed by durvalumab, based on the PACIFIC trial. Disease progression and pneumonitis were reported as the main reasons to preclude the initiation of durvalumab in multiple retrospective studies. However, the transition rate and the reasons for failure to proceed to consolidation therapy with durvalumab after CRT were not evaluated prospectively. Although phase II studies in Japan have shown high efficacy and tolerability of CRT with cisplatin + S-1 (SP), no prospective study using durvalumab after SP-based CRT has yet been reported. We therefore conducted a phase II study to verify the efficacy and safety of durvalumab following SP-based CRT. In this interim analysis, we report the transition rate and the reasons for its failure. Methods: In treatment-naïve LA-NSCLC, cisplatin (60 mg/m 2 , day 1) and S-1 (80–120 mg/body, days 1–14) were administered with two 4-week cycles with concurrent thoracic radiotherapy (60 Gy) followed by durvalumab every 2 weeks for up to 12 months. The primary endpoint was 12 month progression-free survival rate. Results: Fifty-nine patients were enrolled, of whom 86.4% (51/59) proceeded to durvalumab. All of them initiated durvalumab within 42 days after CRT [median 18 days (range: 3–38)], including 27.5% (14/51) in

Walking is a human need. Even when physical disabilities or social situations, such as the COVID-19 pandemic, prevent people from walking, virtual reality can provide an opportunity for virtual walking or travel. In this study, a virtual walking system was developed in which users view omnidirectional movies while receiving scene-congruent vibrations to their left and right forefeet and heels. The timings of foot vibrations were generated by estimating the camera motion trajectory with visual simultaneous localization and mapping (visual SLAM) applied to four omnidirectional movies. Congruent vibration patterns were prepared for four ground scenes. Modulation of walking-related sensations and ground material perceptions by congruent and incongruent vibrations was verified using psychological measurements. The results showed that rhythmic foot vibration improved the sensations of self-motion, walking, leg action, and telepresence irrespective of scene–vibration congruency. Moreover, congruent vibrations were better than incongruent vibrations for walking-related sensations and telepresence in indoor corridors and snowy ground scenes. The perception of ground materials was enhanced by scene-congruent vibrations, whereas it was confused by scene-incongruent vibrations. These findings suggest that vibration patterns do not necessarily need to match the ground exactly to induce virtual walking sensations; however, scene-congruent or similar vibrations improve virtual walking sensations and ground material perception. By applying our methods, we can convert various public omnidirectional movies into realistic virtual walking experiences.

Walking is a fundamental physical activity in humans. Various virtual walking systems have been developed using treadmill or leg-support devices. Using optic flow, foot vibrations simulating footsteps, and a walking avatar, we propose a virtual walking system that does not require limb action for seated users. We aim to investigate whether a full-body or hands-and-feet-only walking avatar with either the first-person (experiment 1) or third-person (experiment 2) perspective can convey the sensation of walking in a virtual environment through optic flows and foot vibrations. The viewing direction of the virtual camera and the head of the full-body avatar were linked to the actual user's head motion. We discovered that the full-body avatar with the first-person perspective enhanced the sensations of walking, leg action, and telepresence, either through synchronous or asynchronous foot vibrations. Although the hands-and-feet-only avatar with the first-person perspective enhanced the walking sensation and telepresence, compared with the no-avatar condition, its effect was less prominent than that of the full-body avatar. However, the full-body avatar with the third-person perspective did not enhance the sensations of walking and leg action; rather, it impaired the sensations of self-motion and telepresence. Synchronous or rhythmic foot vibrations enhanced the sensations of self-motion, waking, leg action, and telepresence, irrespective of the avatar condition. These results suggest that the full-body or hands-and-feet avatar is effective for creating virtual walking experiences from the first-person perspective, but not the third-person perspective, and that the foot vibrations simulating footsteps are effective, regardless of the avatar condition.

Background: Based on the results of the PACIFIC study, chemoradiotherapy followed by 1-year consolidation therapy with durvalumab was established as the standard of care for unresectable, locally advanced non-small-cell lung cancer (LA-NSCLC). However, some topics not foreseen in that design can be explored, including progression-free survival (PFS) and overall survival (OS) after the start of chemoradiotherapy, the proportion of patients who proceeded to consolidation therapy with durvalumab, and the optimal chemotherapeutic regimens. In Japan, the combination regimen of S-1 + cisplatin (SP), for which the results of multiple clinical studies have suggested a good balance of efficacy and tolerability, is frequently selected in clinical settings. However, the efficacy and safety of consolidation therapy with durvalumab following this SP regimen have not been evaluated. We therefore planned a multicenter, prospective, single-arm, phase II study. Methods: In treatment-naïve LA-NSCLC, two cycles of combination chemotherapy with S-1 (80–120 mg/body, Days 1–14) + cisplatin (60 mg/m 2 , Day 1) will be administered at an interval of 4 weeks, with concurrent thoracic radiotherapy (60 Gy). Responders will then receive durvalumab every 2 weeks for up to 1 year. The primary endpoint is 1-year PFS rate. Discussion: Compared with the conventional standard regimen in Japan, the SP regimen is expected to be associated with lower incidences of pneumonitis, esophagitis, and febrile neutropenia, which complicate the initiation of consolidation therapy with durvalumab, and have higher antitumor efficacy during chemoradiotherapy. Therefore, SP-based chemoradiotherapy is expected to be successfully followed by consolidation therapy with durvalumab in more patients, resulting in prolonged PFS and OS. Toxicity and efficacy results of the SP regimen in this study will also provide information important to the future establishment of the concurrent combination of chemoradiotherapy and durvalumab. Trial registration: Japan Registry of Clinical Trials, jRCTs031190127, registered 1 November 2019, https://jrct.niph.go.jp/latest-detail/jRCTs031190127

Visual perspective taking is inferring how the world looks to another person. To clarify this process, we investigated whether employing a humanoid avatar as the viewpoint would facilitate an imagined perspective shift in a virtual environment, and which factor of the avatar is effective for the facilitation effect. We used a task that involved reporting how an object looks by a simple direction judgment, either from the avatar's position or from the position of an empty chair. We found that the humanoid avatar's presence improved task performance. Furthermore, the avatar's facilitation effect was observed only when the avatar was facing the visual stimulus to be judged; performance was worse when it faced backwards than when there was only an empty chair facing forwards. This suggests that the avatar does not simply attract spatial attention, but the posture of the avatar is crucial for the facilitation effect. In addition, when the directions of the head and the torso were opposite (i.e., an impossible posture), the avatar's facilitation effect disappeared. Thus, visual perspective taking might not be facilitated by the avatar when its posture is biomechanically impossible because we cannot embody it. Finally, even when the avatar's head of the possible posture was covered with a bucket, the facilitation effect was found with the forward-facing avatar rather than the backward-facing avatar. That is, the head/gaze direction cue, or presumably the belief that the visual stimulus to be judged can be seen by the avatar, was not required. These results suggest that explicit perspective taking is facilitated by embodiment towards humanoid avatars.

Previous research studies mostly focused on enhancing the security of radio frequency identification (RFID) protocols for various RFID applications that rely on a centralized database. However, blockchain technology is quickly emerging as a novel distributed and decentralized alternative that provides higher data protection, reliability, immutability, transparency, and lower management costs compared with a conventional centralized database. These properties make it extremely suitable for integration in a supply chain management system. In order to successfully fuse RFID and blockchain technologies together, a secure method of communication is required between the RFID tagged goods and the blockchain nodes. Therefore, this paper proposes a robust ultra-lightweight mutual authentication RFID protocol that works together with a decentralized database to create a secure blockchain-enabled supply chain management system. Detailed security analysis is performed to prove that the proposed protocol is secure from key disclosure, replay, man-in-the-middle, de-synchronization, and tracking attacks. In addition to that, a formal analysis is conducted using Gong, Needham, and Yahalom logic and automated validation of internet security protocols and applications tool to verify the security of the proposed protocol. The protocol is proven to be efficient with respect to storage, computational, and communication costs. In addition to that, a further step is taken to ensure the robustness of the protocol by analyzing the probability of data collision written to the blockchain.

Abstract The Z boson in the process pp → ZH and the W + and W − in the process pp → W ± H can be in polarised states. The polarisation density matrix of the Z (W) boson contains the complete information about a state of polarisation of the Z (W) boson, and HZZ, HZγ and HWW interactions may be studied in detail from a careful analysis of these matrices. In this paper, a systematic approach to analyse these polarisation density matrices is presented. With the aim of making maximum use of the polarisation information, all of the elements of the polarisation density matrices are related with observables, which are measurable at the environment of pp collisions. Consequences of non-standard HZZ, HZγ and HWW interactions for these observables are discussed.

A new method to measure the trilinear Higgs self-coupling λ3 in a single Higgs production process is proposed. Time-reversal-odd (T-odd) asymmetries in the process e+e−→ZH, Z→ff¯ are computed from the absorptive part of the electroweak one-loop amplitude. Since the T-odd asymmetries measure the tree-level t-channel ZH→ZH scattering, they can be direct probes of λ3. The proposed method is quite challenging; a relatively large statistics and polarized e+e− beams are demanded. However, this is probably the only approach to directly measure λ3 in e+e− collisions, when a beam energy above the ZHH production threshold is not available.

Abstract TauDecay is a library of helicity amplitudes to simulate polarized tau decays, constructed in the FeynRules and MadGraph5 framework. Together with the leptonic mode, the decay library includes the main hadronic modes, τ→ν τ+π, 2π, and 3π, which are introduced as effective vertices by using FeynRules. The model file allows us to simulate tau decays when the on-shell tau production is kinematically forbidden. We also demonstrate that all possible correlations among the decay products of pair-produced taus through a Z boson and a scalar/pseudoscalar Higgs boson are produced automatically. The program has been tested carefully by making use of the standard tau decay library Tauola.